RASSF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.46539760
2GDP-mannose metabolic process (GO:0019673)4.86976504
3positive regulation of Cdc42 GTPase activity (GO:0043089)4.24796538
4folic acid metabolic process (GO:0046655)4.24042801
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.15905663
6glycine metabolic process (GO:0006544)4.08084393
7actin filament depolymerization (GO:0030042)3.96233187
8nucleobase biosynthetic process (GO:0046112)3.95487382
9purine nucleobase biosynthetic process (GO:0009113)3.93782914
10sulfur amino acid catabolic process (GO:0000098)3.62345298
11serine family amino acid biosynthetic process (GO:0009070)3.61827525
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58866451
13activation of Rac GTPase activity (GO:0032863)3.58687335
14formation of translation preinitiation complex (GO:0001731)3.57851856
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.54858407
16L-phenylalanine metabolic process (GO:0006558)3.54858407
17serine family amino acid catabolic process (GO:0009071)3.49746676
18folic acid-containing compound biosynthetic process (GO:0009396)3.47258591
19proline biosynthetic process (GO:0006561)3.44812167
20hemidesmosome assembly (GO:0031581)3.44651175
21tolerance induction (GO:0002507)3.44292892
22serine family amino acid metabolic process (GO:0009069)3.41426702
23cysteine metabolic process (GO:0006534)3.41129724
24protein carboxylation (GO:0018214)3.41047218
25peptidyl-glutamic acid carboxylation (GO:0017187)3.41047218
26proteasome assembly (GO:0043248)3.33818297
27positive regulation of pseudopodium assembly (GO:0031274)3.33339097
28regulation of cholesterol metabolic process (GO:0090181)3.33044812
29regulation of cholesterol biosynthetic process (GO:0045540)3.32899418
30apoptotic process involved in morphogenesis (GO:0060561)3.30166325
31interferon-gamma secretion (GO:0072643)3.27899556
32DNA deamination (GO:0045006)3.26784920
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25771097
34L-phenylalanine catabolic process (GO:0006559)3.25771097
35regulation of water loss via skin (GO:0033561)3.25195865
36epithelial cell-cell adhesion (GO:0090136)3.21171336
37protein retention in ER lumen (GO:0006621)3.17491836
38bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16678061
39cell-cell junction maintenance (GO:0045217)3.13452709
40multicellular organismal water homeostasis (GO:0050891)3.12779809
41glutathione biosynthetic process (GO:0006750)3.12756627
42regulation of apoptotic process involved in morphogenesis (GO:1902337)3.10034802
43nitrogen cycle metabolic process (GO:0071941)3.08338325
44glyoxylate metabolic process (GO:0046487)3.06636164
45negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.06427888
46mannose metabolic process (GO:0006013)3.05954105
47proline metabolic process (GO:0006560)3.05585895
48intestinal epithelial cell development (GO:0060576)3.02202241
49regulation of hydrogen peroxide metabolic process (GO:0010310)3.02049069
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00016660
51ribosome assembly (GO:0042255)2.99760692
52antigen processing and presentation of endogenous antigen (GO:0019883)2.97760852
53aromatic amino acid family catabolic process (GO:0009074)2.97752760
54calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.95775229
55cellular response to virus (GO:0098586)2.94871403
56glucose catabolic process (GO:0006007)2.94577509
57amyloid precursor protein metabolic process (GO:0042982)2.94163264
58establishment of skin barrier (GO:0061436)2.93685185
59negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.93565985
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93167508
61maturation of SSU-rRNA (GO:0030490)2.93010753
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91982437
63glucose 6-phosphate metabolic process (GO:0051156)2.91944578
64homocysteine metabolic process (GO:0050667)2.91676241
65folic acid-containing compound metabolic process (GO:0006760)2.90380897
66L-serine metabolic process (GO:0006563)2.90200582
67DNA strand elongation involved in DNA replication (GO:0006271)2.88802779
68regulation of defense response to virus by virus (GO:0050690)2.87640743
69tetrahydrofolate metabolic process (GO:0046653)2.84699053
70kynurenine metabolic process (GO:0070189)2.84178947
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83837939
72regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.82521493
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82329256
74pteridine-containing compound biosynthetic process (GO:0042559)2.81502675
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80615955
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80013660
77peptidyl-tyrosine autophosphorylation (GO:0038083)2.79922641
78regulation of cellular amino acid metabolic process (GO:0006521)2.79444836
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79193181
80amyloid precursor protein catabolic process (GO:0042987)2.79111134
81antigen processing and presentation via MHC class Ib (GO:0002475)2.78834463
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78626908
83regulation of pseudopodium assembly (GO:0031272)2.78613504
84nonribosomal peptide biosynthetic process (GO:0019184)2.78107545
85glutamine family amino acid biosynthetic process (GO:0009084)2.77647047
86tryptophan catabolic process (GO:0006569)2.77310619
87indole-containing compound catabolic process (GO:0042436)2.77310619
88indolalkylamine catabolic process (GO:0046218)2.77310619
89ribosomal large subunit biogenesis (GO:0042273)2.76829128
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75539258
91intestinal cholesterol absorption (GO:0030299)2.75188190
92DNA replication initiation (GO:0006270)2.74878426
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73807799
94ribosome biogenesis (GO:0042254)2.72869533
95atrioventricular valve morphogenesis (GO:0003181)2.71808878
96DNA strand elongation (GO:0022616)2.71685378
97NIK/NF-kappaB signaling (GO:0038061)2.71438921
98semaphorin-plexin signaling pathway (GO:0071526)2.71334484
99regulation of viral release from host cell (GO:1902186)2.71303236
100regulation of extracellular matrix disassembly (GO:0010715)2.70897604
101lysine metabolic process (GO:0006553)2.70746152
102lysine catabolic process (GO:0006554)2.70746152
103endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.70227583
104phospholipid efflux (GO:0033700)2.70089485
105nucleoside diphosphate biosynthetic process (GO:0009133)2.70055873
106cellular zinc ion homeostasis (GO:0006882)2.69780162
107positive regulation of triglyceride metabolic process (GO:0090208)2.69292933
108regulation of respiratory burst (GO:0060263)2.68166413
109nucleoside salvage (GO:0043174)2.67730213
110basement membrane organization (GO:0071711)2.67059276
111regulation of gene silencing by miRNA (GO:0060964)2.66734964
112regulation of gene silencing by RNA (GO:0060966)2.66734964
113regulation of posttranscriptional gene silencing (GO:0060147)2.66734964
114sulfur amino acid biosynthetic process (GO:0000097)2.66697126
115regulation of ruffle assembly (GO:1900027)2.66374376
116folic acid transport (GO:0015884)2.66362618
117tryptophan metabolic process (GO:0006568)2.66069031
118amino-acid betaine metabolic process (GO:0006577)2.64569437
119NADH metabolic process (GO:0006734)2.63696241
120positive regulation of histone deacetylation (GO:0031065)2.62286447
121DNA replication checkpoint (GO:0000076)2.61732945
122pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.61447824
123pteridine-containing compound metabolic process (GO:0042558)2.61204124
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60645598
125negative regulation of ligase activity (GO:0051352)2.60645598
126viral transcription (GO:0019083)2.60525309
127negative regulation of viral release from host cell (GO:1902187)2.60202355
128telomere maintenance via semi-conservative replication (GO:0032201)2.59760746
129pentose-phosphate shunt (GO:0006098)2.59356388
130urea metabolic process (GO:0019627)2.59311353
131urea cycle (GO:0000050)2.59311353
132ribosomal small subunit assembly (GO:0000028)2.59254239
133ribonucleoprotein complex biogenesis (GO:0022613)2.58572703
134protein insertion into membrane (GO:0051205)2.58341824
135aromatic amino acid family metabolic process (GO:0009072)2.58210792
136mitotic metaphase plate congression (GO:0007080)2.57916543
137cell junction maintenance (GO:0034331)2.57506404
138translational initiation (GO:0006413)2.56542445
139regulation of cholesterol homeostasis (GO:2000188)2.55979283
140negative regulation of sterol transport (GO:0032372)2.55142539
141negative regulation of cholesterol transport (GO:0032375)2.55142539
142translational elongation (GO:0006414)2.54760999
143negative regulation of fibrinolysis (GO:0051918)2.54702861
144high-density lipoprotein particle remodeling (GO:0034375)2.54178393
145translational termination (GO:0006415)2.53649247
146positive regulation of lipoprotein lipase activity (GO:0051006)2.53179135
147positive regulation of triglyceride lipase activity (GO:0061365)2.53179135
148DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52158160
149primary alcohol catabolic process (GO:0034310)2.51023964
150negative regulation of glycoprotein biosynthetic process (GO:0010561)2.50906835
151lung epithelium development (GO:0060428)2.50858028
152positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50681284
153IMP biosynthetic process (GO:0006188)2.49637862
154COPI coating of Golgi vesicle (GO:0048205)2.49272990
155Golgi transport vesicle coating (GO:0048200)2.49272990
156water homeostasis (GO:0030104)2.49145276
157intestinal absorption (GO:0050892)2.48906319
158pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.48730049
159signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47844376
160signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47844376
161signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47844376
162L-methionine salvage (GO:0071267)2.47770847
163L-methionine biosynthetic process (GO:0071265)2.47770847
164amino acid salvage (GO:0043102)2.47770847
165heme transport (GO:0015886)2.47311633
166intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.47279076
167signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.47279076
168signal transduction involved in DNA integrity checkpoint (GO:0072401)2.46385183
169signal transduction involved in DNA damage checkpoint (GO:0072422)2.46385183
170deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46290596
171DNA replication-dependent nucleosome assembly (GO:0006335)2.46032333
172flavonoid metabolic process (GO:0009812)2.43827028
173fat-soluble vitamin biosynthetic process (GO:0042362)2.43817625
174regulation of extracellular matrix organization (GO:1903053)2.43006892
175ethanol metabolic process (GO:0006067)2.41566515
176negative regulation of cell size (GO:0045792)2.40925671
177epoxygenase P450 pathway (GO:0019373)2.40505888
178viral protein processing (GO:0019082)2.39520159
179regulation of actin nucleation (GO:0051125)2.38984626
180virion assembly (GO:0019068)2.37435736
181regulation of Cdc42 GTPase activity (GO:0043088)2.36588266
182regulation of gamma-delta T cell differentiation (GO:0045586)2.34982521
183negative regulation of glycoprotein metabolic process (GO:1903019)2.34624026
184Arp2/3 complex-mediated actin nucleation (GO:0034314)2.33790073
185regulation of cellular extravasation (GO:0002691)2.33493658
186maternal placenta development (GO:0001893)2.33375197
187nuclear envelope reassembly (GO:0031468)2.33327902
188mitotic nuclear envelope reassembly (GO:0007084)2.33327902
189regulation of triglyceride catabolic process (GO:0010896)2.31228155
190citrulline biosynthetic process (GO:0019240)2.30158664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.28923178
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.44716348
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.42349371
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36984146
5LXR_22292898_ChIP-Seq_THP-1_Human2.86349630
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.75909230
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61082968
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53885608
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.53397157
10VDR_21846776_ChIP-Seq_THP-1_Human2.50360487
11* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48109083
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46786094
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41831894
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.39604141
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35235691
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.34263359
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.31980990
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31767117
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30510612
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.25116759
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.24241839
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22861519
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.22387898
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21405889
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10193922
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.04925399
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95376600
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93919540
29XRN2_22483619_ChIP-Seq_HELA_Human1.92450603
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90380644
31P68_20966046_ChIP-Seq_HELA_Human1.88345174
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87457542
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.84886554
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83535916
35ZNF263_19887448_ChIP-Seq_K562_Human1.83297060
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81522698
37AR_21909140_ChIP-Seq_LNCAP_Human1.80499532
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80308997
39* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78720372
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75761286
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74476628
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.69743529
43DCP1A_22483619_ChIP-Seq_HELA_Human1.69228744
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68518601
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67963377
46BCOR_27268052_Chip-Seq_Bcells_Human1.67731107
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.67633751
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66002877
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65830627
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65394195
51BCL6_27268052_Chip-Seq_Bcells_Human1.65334682
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63816286
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61606996
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61250075
55GABP_19822575_ChIP-Seq_HepG2_Human1.60784893
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58790682
57TCF7_22412390_ChIP-Seq_EML_Mouse1.56521465
58* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55489629
59KDM2B_26808549_Chip-Seq_DND41_Human1.54151859
60SMC4_20622854_ChIP-Seq_HELA_Human1.52529556
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.52454669
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52397382
63VDR_23849224_ChIP-Seq_CD4+_Human1.51490730
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.50712485
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48363108
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46651209
67* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45388649
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45068406
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44627307
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42588719
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41615928
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41325049
73CREB1_26743006_Chip-Seq_LNCaP_Human1.40717773
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39470823
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39279852
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.38766648
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38127053
78FOXP3_21729870_ChIP-Seq_TREG_Human1.37690035
79VDR_24763502_ChIP-Seq_THP-1_Human1.37319390
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36879678
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36599534
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34722944
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.34425801
84CTCF_27219007_Chip-Seq_Bcells_Human1.34021840
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33834606
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32925785
87* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31304754
88KDM5A_27292631_Chip-Seq_BREAST_Human1.31108589
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.31043358
90SA1_27219007_Chip-Seq_Bcells_Human1.30858975
91PHF8_20622854_ChIP-Seq_HELA_Human1.30188504
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.30146163
93E2F1_20622854_ChIP-Seq_HELA_Human1.29636443
94MAF_26560356_Chip-Seq_TH2_Human1.29169494
95* MAF_26560356_Chip-Seq_TH1_Human1.28693092
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28515692
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.28087750
98TTF2_22483619_ChIP-Seq_HELA_Human1.27018154
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26833690
100NCOR1_26117541_ChIP-Seq_K562_Human1.26645026
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26251518
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25566543
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.25273697
104TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24785862
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24297877
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23933786
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23112269
108UTX_26944678_Chip-Seq_JUKART_Human1.22404289
109KDM2B_26808549_Chip-Seq_K562_Human1.21900948
110TP63_22573176_ChIP-Seq_HFKS_Human1.21428700
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20113377
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19853403
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18885950
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18756684
115* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18060481
116* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18046086
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17992683
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.17772599
119* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17134097
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16999405
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.16769222
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16247719
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.16133872
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16114780
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15475104
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13051945
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11967261
128* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11915203
129CTCF_20526341_ChIP-Seq_ESCs_Human1.10996500
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10106485
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10068755
132CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09680390
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.09150544
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09064987
135ATF3_27146783_Chip-Seq_COLON_Human1.08747277
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08542670
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07886699
138* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06483446
139CTCF_21964334_Chip-Seq_Bcells_Human1.06164296
140* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05685155
141MYC_22102868_ChIP-Seq_BL_Human1.04181748
142ETS1_21867929_ChIP-Seq_TH2_Mouse1.03382165
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03220363
144* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02521566
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02287980
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02278538
147YY1_22570637_ChIP-Seq_MALME-3M_Human1.01922712
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01803801
149RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01597932
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01312472
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01211332
152* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00799140
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00662395
154KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99756313
155SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98229682
156CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98134678
157TP53_22127205_ChIP-Seq_IMR90_Human0.98049219
158SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98038747
159EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97520898
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95150258
161GATA6_25053715_ChIP-Seq_YYC3_Human0.94743136
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94325098
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.93791109
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92903047
165CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92479934
166CIITA_25753668_ChIP-Seq_RAJI_Human0.92433976
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89876867
168ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89781340
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89617501
170KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89282480
171GATA4_25053715_ChIP-Seq_YYC3_Human0.87004933
172POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86539519
173CLOCK_20551151_ChIP-Seq_293T_Human0.85983447
174KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85924185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.64462806
2MP0005360_urolithiasis4.26024238
3MP0003806_abnormal_nucleotide_metabolis3.89522595
4MP0003693_abnormal_embryo_hatching3.79003794
5MP0005085_abnormal_gallbladder_physiolo3.42427477
6MP0005365_abnormal_bile_salt3.25899657
7MP0009840_abnormal_foam_cell3.02922344
8MP0004957_abnormal_blastocyst_morpholog2.70906345
9MP0005058_abnormal_lysosome_morphology2.66196270
10MP0008875_abnormal_xenobiotic_pharmacok2.60634109
11MP0010234_abnormal_vibrissa_follicle2.55985215
12MP0001666_abnormal_nutrient_absorption2.33141778
13MP0010352_gastrointestinal_tract_polyps2.16372583
14MP0003111_abnormal_nucleus_morphology2.12594298
15MP0004264_abnormal_extraembryonic_tissu2.04970542
16MP0001873_stomach_inflammation2.02495333
17MP0002796_impaired_skin_barrier1.99624141
18MP0005083_abnormal_biliary_tract1.92856716
19MP0004019_abnormal_vitamin_homeostasis1.91015354
20MP0003252_abnormal_bile_duct1.87452839
21MP0008260_abnormal_autophagy1.83978177
22MP0003705_abnormal_hypodermis_morpholog1.83280226
23MP0005332_abnormal_amino_acid1.83244290
24MP0000678_abnormal_parathyroid_gland1.82586958
25MP0009333_abnormal_splenocyte_physiolog1.82362158
26MP0010329_abnormal_lipoprotein_level1.78566416
27MP0003172_abnormal_lysosome_physiology1.75184612
28MP0003077_abnormal_cell_cycle1.74851020
29MP0003866_abnormal_defecation1.74845022
30MP0010155_abnormal_intestine_physiology1.74048700
31MP0010030_abnormal_orbit_morphology1.67860582
32MP0010094_abnormal_chromosome_stability1.65980047
33MP0000537_abnormal_urethra_morphology1.64493619
34MP0002138_abnormal_hepatobiliary_system1.63993321
35MP0003941_abnormal_skin_development1.63410942
36MP0004947_skin_inflammation1.60012440
37MP0003436_decreased_susceptibility_to1.59891836
38MP0003718_maternal_effect1.59597960
39MP0005501_abnormal_skin_physiology1.51134326
40MP0003191_abnormal_cellular_cholesterol1.50472793
41MP0004858_abnormal_nervous_system1.48192318
42MP0003186_abnormal_redox_activity1.47606849
43MP0009643_abnormal_urine_homeostasis1.44116510
44MP0001730_embryonic_growth_arrest1.43803287
45MP0000858_altered_metastatic_potential1.41448834
46MP0003763_abnormal_thymus_physiology1.39571474
47MP0003195_calcinosis1.35928655
48MP0008932_abnormal_embryonic_tissue1.32814025
49MP0003315_abnormal_perineum_morphology1.30736387
50MP0000609_abnormal_liver_physiology1.30498213
51MP0001764_abnormal_homeostasis1.27626836
52MP0005319_abnormal_enzyme/_coenzyme1.27160558
53MP0004782_abnormal_surfactant_physiolog1.25460896
54MP0008058_abnormal_DNA_repair1.25412074
55MP0009053_abnormal_anal_canal1.23182806
56MP0001664_abnormal_digestion1.22809574
57MP0001765_abnormal_ion_homeostasis1.21459444
58MP0000467_abnormal_esophagus_morphology1.20592184
59MP0010678_abnormal_skin_adnexa1.17326354
60MP0008007_abnormal_cellular_replicative1.15062207
61MP0002098_abnormal_vibrissa_morphology1.14629852
62MP0003890_abnormal_embryonic-extraembry1.14446861
63MP0005025_abnormal_response_to1.13936829
64MP0003786_premature_aging1.13014261
65MP0005409_darkened_coat_color1.09891734
66MP0002249_abnormal_larynx_morphology1.09634460
67MP0001756_abnormal_urination1.09568924
68MP0003119_abnormal_digestive_system1.09493183
69MP0005075_abnormal_melanosome_morpholog1.08409045
70MP0005220_abnormal_exocrine_pancreas1.08180799
71MP0003878_abnormal_ear_physiology1.06167626
72MP0005377_hearing/vestibular/ear_phenot1.06167626
73MP0000350_abnormal_cell_proliferation1.05868618
74MP0000490_abnormal_crypts_of1.05166551
75MP0004381_abnormal_hair_follicle1.02448660
76MP0005464_abnormal_platelet_physiology1.02385247
77MP0002089_abnormal_postnatal_growth/wei1.01799319
78MP0001672_abnormal_embryogenesis/_devel1.00641686
79MP0005380_embryogenesis_phenotype1.00641686
80MP0005451_abnormal_body_composition0.99609857
81MP0009931_abnormal_skin_appearance0.99135190
82MP0003183_abnormal_peptide_metabolism0.98894809
83MP0001697_abnormal_embryo_size0.96710862
84MP0006035_abnormal_mitochondrial_morpho0.96210263
85MP0000598_abnormal_liver_morphology0.96190201
86MP0006036_abnormal_mitochondrial_physio0.95612228
87MP0000579_abnormal_nail_morphology0.94392416
88MP0002080_prenatal_lethality0.94136304
89MP0001216_abnormal_epidermal_layer0.93013769
90MP0005084_abnormal_gallbladder_morpholo0.92933975
91MP0005076_abnormal_cell_differentiation0.92631828
92MP0000462_abnormal_digestive_system0.91651400
93MP0002060_abnormal_skin_morphology0.90949287
94MP0000685_abnormal_immune_system0.90453243
95MP0010771_integument_phenotype0.90271935
96MP0002088_abnormal_embryonic_growth/wei0.89558537
97MP0003984_embryonic_growth_retardation0.89276488
98MP0000003_abnormal_adipose_tissue0.88919910
99MP0000477_abnormal_intestine_morphology0.88239514
100MP0005023_abnormal_wound_healing0.87365008
101MP0002118_abnormal_lipid_homeostasis0.86009958
102MP0002086_abnormal_extraembryonic_tissu0.85441384
103MP0001663_abnormal_digestive_system0.85365591
104MP0005166_decreased_susceptibility_to0.84259456
105MP0004197_abnormal_fetal_growth/weight/0.82394929
106MP0001845_abnormal_inflammatory_respons0.82021627
107MP0005381_digestive/alimentary_phenotyp0.81702391
108MP0002085_abnormal_embryonic_tissue0.81048335
109MP0008469_abnormal_protein_level0.80834154
110MP0002166_altered_tumor_susceptibility0.80658080
111MP0009379_abnormal_foot_pigmentation0.80300332
112MP0005636_abnormal_mineral_homeostasis0.79916992
113MP0001348_abnormal_lacrimal_gland0.78932468
114MP0001819_abnormal_immune_cell0.78787800
115MP0003453_abnormal_keratinocyte_physiol0.78787103
116MP0002452_abnormal_antigen_presenting0.78358681
117MP0000358_abnormal_cell_content/0.77747121
118MP0009278_abnormal_bone_marrow0.77729857
119MP0001293_anophthalmia0.77066559
120MP0009672_abnormal_birth_weight0.76729528
121MP0000470_abnormal_stomach_morphology0.76722213
122MP0005408_hypopigmentation0.75895622
123MP0002084_abnormal_developmental_patter0.75198720
124MP0001849_ear_inflammation0.74994763
125MP0002132_abnormal_respiratory_system0.74612053
126MP0003879_abnormal_hair_cell0.74507157
127MP0003567_abnormal_fetal_cardiomyocyte0.73986084
128MP0004133_heterotaxia0.73951509
129MP0002420_abnormal_adaptive_immunity0.73935220
130MP0002419_abnormal_innate_immunity0.73137483
131MP0000367_abnormal_coat/_hair0.72365788
132MP0005387_immune_system_phenotype0.72342596
133MP0001790_abnormal_immune_system0.72342596
134MP0000377_abnormal_hair_follicle0.71805193
135MP0003123_paternal_imprinting0.71796580
136MP0000516_abnormal_urinary_system0.71709980
137MP0005367_renal/urinary_system_phenotyp0.71709980
138MP0002254_reproductive_system_inflammat0.71442332
139MP0002019_abnormal_tumor_incidence0.71420563
140MP0004185_abnormal_adipocyte_glucose0.71397037
141MP0003300_gastrointestinal_ulcer0.71294503
142MP0002136_abnormal_kidney_physiology0.70288350
143MP0005395_other_phenotype0.68718423
144MP0005266_abnormal_metabolism0.68070007
145MP0003566_abnormal_cell_adhesion0.66293736
146MP0000313_abnormal_cell_death0.66083058
147MP0002160_abnormal_reproductive_system0.64157107
148MP0000566_synostosis0.63897881
149MP0008057_abnormal_DNA_replication0.62613339
150MP0005389_reproductive_system_phenotype0.62078298
151MP0002111_abnormal_tail_morphology0.61688634
152MP0002653_abnormal_ependyma_morphology0.61417008

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)4.70208613
2Hypobetalipoproteinemia (HP:0003563)4.34729934
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.23448841
4Intrahepatic cholestasis (HP:0001406)4.04584082
5Hyperglycinuria (HP:0003108)3.93793027
6Hyperglycinemia (HP:0002154)3.75491919
7Thin bony cortex (HP:0002753)3.69579047
8Gout (HP:0001997)3.55041001
9Xanthomatosis (HP:0000991)3.51622325
10Abnormality of serine family amino acid metabolism (HP:0010894)3.36237210
11Abnormality of glycine metabolism (HP:0010895)3.36237210
12Hemorrhage of the eye (HP:0011885)3.32568434
13Malnutrition (HP:0004395)3.25351848
14Breast hypoplasia (HP:0003187)3.22996443
15Abnormality of pyrimidine metabolism (HP:0004353)3.19466752
16J-shaped sella turcica (HP:0002680)3.17414740
17Hypolipoproteinemia (HP:0010981)3.15816184
18Hyperammonemia (HP:0001987)3.12614971
19Hypoglycemic coma (HP:0001325)3.09294866
20Abnormal hair laboratory examination (HP:0003328)3.04787027
21Stridor (HP:0010307)3.04220402
22Deep venous thrombosis (HP:0002625)2.91999027
23Broad face (HP:0000283)2.86671815
24Upper limb amyotrophy (HP:0009129)2.83636043
25Distal upper limb amyotrophy (HP:0007149)2.83636043
26Microretrognathia (HP:0000308)2.81275779
27Abnormality of sulfur amino acid metabolism (HP:0004339)2.80927558
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77593181
29Birth length less than 3rd percentile (HP:0003561)2.74687407
30Ileus (HP:0002595)2.73101688
31Pustule (HP:0200039)2.72535710
32Flat acetabular roof (HP:0003180)2.68818996
33Abnormality of nucleobase metabolism (HP:0010932)2.67896801
34Multiple enchondromatosis (HP:0005701)2.66327223
35Carpal bone hypoplasia (HP:0001498)2.65840748
36Oral leukoplakia (HP:0002745)2.63871541
37Abnormality of cells of the erythroid lineage (HP:0012130)2.63645848
38Eczematoid dermatitis (HP:0000976)2.62739451
39Hyperlipoproteinemia (HP:0010980)2.58957072
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58497245
41Trismus (HP:0000211)2.57608863
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53813331
43Dicarboxylic aciduria (HP:0003215)2.53813331
44Abnormality of the distal phalanges of the toes (HP:0010182)2.52961742
45Proximal tubulopathy (HP:0000114)2.52302647
46Right ventricular cardiomyopathy (HP:0011663)2.52113995
47Fat malabsorption (HP:0002630)2.51061885
48Megaloblastic anemia (HP:0001889)2.49744116
49Milia (HP:0001056)2.49584065
50Late onset (HP:0003584)2.47127182
51Easy fatigability (HP:0003388)2.45666384
52Abnormality of the anterior horn cell (HP:0006802)2.45400923
53Degeneration of anterior horn cells (HP:0002398)2.45400923
54Abnormality of purine metabolism (HP:0004352)2.42111825
55Abnormality of fatty-acid metabolism (HP:0004359)2.41481419
56Hypoalphalipoproteinemia (HP:0003233)2.40770585
57Prolonged partial thromboplastin time (HP:0003645)2.40071776
58Abdominal distention (HP:0003270)2.39856396
59Cerebral palsy (HP:0100021)2.39287043
60Abnormality of serum amino acid levels (HP:0003112)2.37931952
61Growth hormone excess (HP:0000845)2.37099535
62Lethargy (HP:0001254)2.33840923
63Seborrheic dermatitis (HP:0001051)2.33380773
64Onycholysis (HP:0001806)2.31546592
65Increased IgE level (HP:0003212)2.31151317
66Nasal polyposis (HP:0100582)2.30050304
67Ketosis (HP:0001946)2.29801518
68Cervical subluxation (HP:0003308)2.28024397
69Widely patent fontanelles and sutures (HP:0004492)2.25166584
70Axonal loss (HP:0003447)2.23985256
71Aplasia/hypoplasia of the femur (HP:0005613)2.23304087
72Focal segmental glomerulosclerosis (HP:0000097)2.22863124
73Interstitial pulmonary disease (HP:0006530)2.22697085
74Hyperuricemia (HP:0002149)2.21867215
75Increased purine levels (HP:0004368)2.21867215
76Macrocytic anemia (HP:0001972)2.21768556
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21632750
78IgM deficiency (HP:0002850)2.19896119
79Ragged-red muscle fibers (HP:0003200)2.18869826
80Biliary tract neoplasm (HP:0100574)2.18208948
81Distal lower limb muscle weakness (HP:0009053)2.18015043
82Abnormal biliary tract morphology (HP:0012440)2.18004029
83Generalized aminoaciduria (HP:0002909)2.17331050
84Distal lower limb amyotrophy (HP:0008944)2.15550362
85Alopecia of scalp (HP:0002293)2.13800190
86Progressive muscle weakness (HP:0003323)2.13618338
87Flattened epiphyses (HP:0003071)2.13151680
88Hypertensive crisis (HP:0100735)2.12194618
89Abnormal number of erythroid precursors (HP:0012131)2.11698946
90Acanthosis nigricans (HP:0000956)2.11015762
91Amelogenesis imperfecta (HP:0000705)2.10480546
92Fragile nails (HP:0001808)2.10265400
93Elevated erythrocyte sedimentation rate (HP:0003565)2.09086427
94Nausea (HP:0002018)2.09031827
95Abnormal cartilage morphology (HP:0002763)2.08988583
96Hypertriglyceridemia (HP:0002155)2.08771754
97Death in infancy (HP:0001522)2.08762765
98Glomerulosclerosis (HP:0000096)2.07926647
99Gastrointestinal dysmotility (HP:0002579)2.07610978
100Abnormality of alkaline phosphatase activity (HP:0004379)2.06319367
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06114643
102Cholecystitis (HP:0001082)2.04469140
103Abnormal gallbladder physiology (HP:0012438)2.04469140
104Rough bone trabeculation (HP:0100670)2.04211197
105Abnormality of the nasal mucosa (HP:0000433)2.04032306
106Dysostosis multiplex (HP:0000943)2.03979040
107Abnormal enzyme/coenzyme activity (HP:0012379)2.03655179
108Hypophosphatemia (HP:0002148)2.02243087
109Short nail (HP:0001799)2.01987275
110Nail dystrophy (HP:0008404)2.01952018
111Prolonged neonatal jaundice (HP:0006579)2.01832800
112Polygenic inheritance (HP:0010982)2.00702836
113Abnormality of methionine metabolism (HP:0010901)2.00006053
114Testicular atrophy (HP:0000029)1.99338668
115B lymphocytopenia (HP:0010976)1.98906298
116Chronic bronchitis (HP:0004469)1.97923548
117Sparse eyelashes (HP:0000653)1.97869443
118Delayed CNS myelination (HP:0002188)1.97210923
119Reticulocytopenia (HP:0001896)1.96816454
120Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.96545483
121Selective tooth agenesis (HP:0001592)1.96436088
122Hand muscle atrophy (HP:0009130)1.95997777
123Systemic lupus erythematosus (HP:0002725)1.95849323
124Plantar hyperkeratosis (HP:0007556)1.95804206
125Impulsivity (HP:0100710)1.95493985
126Glycosuria (HP:0003076)1.94131892
127Abnormality of urine glucose concentration (HP:0011016)1.94131892
128Delayed epiphyseal ossification (HP:0002663)1.92553596
129Colon cancer (HP:0003003)1.92400013
130Abnormality of B cell number (HP:0010975)1.92293113
131Abnormal blistering of the skin (HP:0008066)1.91549744
132Abnormality of macrophages (HP:0004311)1.91413117
133Urinary glycosaminoglycan excretion (HP:0003541)1.91402916
134Mucopolysacchariduria (HP:0008155)1.91402916
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.90956524
136Spastic diplegia (HP:0001264)1.90873553
137Irritability (HP:0000737)1.90463879
138Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90077505
139Subcapsular cataract (HP:0000523)1.88180204
140Mildly elevated creatine phosphokinase (HP:0008180)1.85805921
141Mediastinal lymphadenopathy (HP:0100721)1.85727354
142Increased serum ferritin (HP:0003281)1.85401353
143Abnormality of polysaccharide metabolism (HP:0011012)1.84998340
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84998340
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84998340
146Obstructive sleep apnea (HP:0002870)1.84368687
147Ketoacidosis (HP:0001993)1.84066921
148Steatorrhea (HP:0002570)1.82972532
149Elevated alkaline phosphatase (HP:0003155)1.82792439
150Abnormality of transition element cation homeostasis (HP:0011030)1.82768433
151Abnormal trabecular bone morphology (HP:0100671)1.81945438
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81654500
153Hyperbilirubinemia (HP:0002904)1.80592934
154Abnormality of the intrinsic pathway (HP:0010989)1.80477027
155Pili torti (HP:0003777)1.80434674
156Long palpebral fissure (HP:0000637)1.79969274
157Ependymoma (HP:0002888)1.78162781
158Congenital ichthyosiform erythroderma (HP:0007431)1.78000348
159Patellar aplasia (HP:0006443)1.77814602
160Metabolic acidosis (HP:0001942)1.77591462
161Gastrointestinal inflammation (HP:0004386)1.77389272
162Bowing of the arm (HP:0006488)1.76402629
163Bowed forearm bones (HP:0003956)1.76402629
164Polar cataract (HP:0010696)1.76240440
165Conjugated hyperbilirubinemia (HP:0002908)1.75943657
166Premature ovarian failure (HP:0008209)1.75715113
167Increased cerebral lipofuscin (HP:0011813)1.75353626
168Hyperacusis (HP:0010780)1.75040224
169Abnormality of small intestinal villus morphology (HP:0011472)1.74894011
170Villous atrophy (HP:0011473)1.74894011
171Abnormal pancreas size (HP:0012094)1.74248904
172Aplasia/Hypoplasia of the patella (HP:0006498)1.73389853
173Broad distal phalanx of finger (HP:0009836)1.73090344
174Hepatocellular carcinoma (HP:0001402)1.72376418
175Woolly hair (HP:0002224)1.71289092
176Secondary amenorrhea (HP:0000869)1.69979399
177Abnormality of complement system (HP:0005339)1.69295906
178Wide cranial sutures (HP:0010537)1.68699956
179Abnormal hemoglobin (HP:0011902)1.68181404
180Bone pain (HP:0002653)1.67645601
181Hyperactive renin-angiotensin system (HP:0000841)1.67195954
182Abnormality of the common coagulation pathway (HP:0010990)1.67096193
183Posterior subcapsular cataract (HP:0007787)1.66840343
184Esophageal varix (HP:0002040)1.66292964
185Neoplasm of the pancreas (HP:0002894)1.65726969
186Rhabdomyolysis (HP:0003201)1.64697988
187Microvesicular hepatic steatosis (HP:0001414)1.64348303
188Brushfield spots (HP:0001088)1.64283227
189Vascular calcification (HP:0004934)1.63786225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.38700482
2BUB14.61304890
3BCKDK2.88989081
4WEE12.85080031
5LMTK22.80172211
6EIF2AK12.78192984
7ACVR1B2.36530907
8MST1R2.21035495
9RPS6KB22.21029085
10SMG12.04863185
11STK38L2.03205980
12EIF2AK31.95527779
13NEK11.94264914
14MAP4K11.84738459
15TTK1.77852576
16STK161.75549418
17NEK21.66967556
18TSSK61.64750801
19MAPKAPK31.63470233
20MAP2K21.63320852
21TBK11.63171569
22ERN11.60362175
23MAP3K131.58263815
24NME21.53320694
25DYRK31.52267346
26SRPK11.47758261
27TESK21.47151027
28EPHB11.45508402
29RPS6KA41.42265804
30PLK41.41834861
31MAP3K31.41364855
32TNK21.41243290
33PASK1.40091904
34PIM21.38777688
35TESK11.38321136
36PAK41.34800097
37BMX1.33837741
38MAP3K81.29982870
39NME11.28901523
40PLK11.27107332
41TAOK11.26695152
42CDC71.26267185
43AURKB1.25567670
44BRSK21.23635885
45PRKCI1.22611819
46MAP3K111.20718589
47IRAK31.20343750
48MST41.17517603
49AKT31.15547349
50MUSK1.11890365
51BRAF1.11690746
52PRPF4B1.10609767
53IRAK41.09789705
54AURKA1.07496740
55MET1.04881962
56STK101.04380187
57CDK71.02342075
58PRKD21.01471087
59MAP3K11.00480757
60PKN21.00244894
61SIK30.96665000
62KDR0.95978595
63LRRK20.93984889
64ICK0.92393822
65MAP3K100.89611979
66GRK60.89177268
67CHEK20.86107457
68MARK20.85051833
69MAP3K90.84849577
70CSK0.83890615
71PDPK10.83147425
72CDK40.82934036
73TRIB30.82041514
74FLT30.80650977
75ZAP700.79084628
76FGFR40.76035831
77EEF2K0.75101348
78SCYL20.74999693
79MAP2K60.73061078
80PLK30.72916837
81RPS6KA20.71060136
82BRSK10.70621969
83MAP2K30.69650973
84DYRK1B0.68899323
85ARAF0.68025110
86ATR0.66803040
87IKBKE0.66451934
88EPHB20.66260205
89TYK20.65830514
90WNK30.65047603
91MAP3K20.64710824
92MAP2K10.64665452
93IRAK20.64531821
94PIM10.63388796
95DAPK10.62887647
96PTK60.62591946
97PAK10.62054059
98MAP3K60.60516294
99MAPK150.60022981
100HIPK20.59227818
101CDK60.58269869
102TGFBR10.57826894
103SIK10.57383380
104RIPK40.57304035
105MAPK110.56719992
106ZAK0.55524221
107TLK10.55518947
108VRK10.54322600
109TAOK20.53865272
110BTK0.53253192
111CSNK2A10.51804086
112PTK20.50388623
113MELK0.46380985
114MAP3K70.46363252
115CHEK10.46026996
116STK40.45652022
117RIPK10.45177911
118RPS6KC10.44711472
119RPS6KL10.44711472
120CSF1R0.44176797
121PIK3CG0.44154909
122ERBB20.44051092
123MTOR0.44005257
124AKT20.43395535
125LATS10.43371644
126CSNK2A20.42849009
127PDK10.42548512
128CDC42BPA0.41663621
129LIMK10.40720522
130JAK30.39382756
131MAPKAPK20.39323154
132ILK0.38070538
133FRK0.36530609
134PRKG20.35426415
135STK380.34994186
136ITK0.34763863
137STK240.34495666
138CDK20.34267374
139ABL20.33346134
140STK30.33050547
141IKBKB0.32036790
142RPS6KA10.31011049
143RPS6KA60.30047039
144MATK0.30012118
145TAOK30.29991244
146KSR20.27437666
147VRK20.27167045
148FER0.25431320
149MAP3K140.23906205
150SRC0.22583736

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.04469202
2Proteasome_Homo sapiens_hsa030502.81384786
3Folate biosynthesis_Homo sapiens_hsa007902.41813639
4DNA replication_Homo sapiens_hsa030302.35861071
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32302831
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24255250
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24163135
8Ribosome_Homo sapiens_hsa030102.13529500
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.08839423
10Selenocompound metabolism_Homo sapiens_hsa004502.04626604
11One carbon pool by folate_Homo sapiens_hsa006702.04093507
12Mismatch repair_Homo sapiens_hsa034302.01072049
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.98302832
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.93897122
15RNA polymerase_Homo sapiens_hsa030201.88487135
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82787656
17Primary immunodeficiency_Homo sapiens_hsa053401.79270838
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78745301
19Pyrimidine metabolism_Homo sapiens_hsa002401.74445462
20Biosynthesis of amino acids_Homo sapiens_hsa012301.73264556
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73121366
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71205614
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.67819200
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67731610
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.64634724
26Tryptophan metabolism_Homo sapiens_hsa003801.63510093
27Fat digestion and absorption_Homo sapiens_hsa049751.61177408
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.56754877
29Spliceosome_Homo sapiens_hsa030401.55917282
30Notch signaling pathway_Homo sapiens_hsa043301.54727408
31RNA transport_Homo sapiens_hsa030131.54497770
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51644732
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50943510
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48739755
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47558736
36Fatty acid degradation_Homo sapiens_hsa000711.47250409
37Arginine biosynthesis_Homo sapiens_hsa002201.46594838
38Carbon metabolism_Homo sapiens_hsa012001.46106087
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45941174
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45481272
41Sulfur relay system_Homo sapiens_hsa041221.44877011
42Glutathione metabolism_Homo sapiens_hsa004801.43635765
43Histidine metabolism_Homo sapiens_hsa003401.43523020
44Base excision repair_Homo sapiens_hsa034101.42599995
45Sulfur metabolism_Homo sapiens_hsa009201.38134915
46Caffeine metabolism_Homo sapiens_hsa002321.36371386
47Fructose and mannose metabolism_Homo sapiens_hsa000511.31929704
48Acute myeloid leukemia_Homo sapiens_hsa052211.31810247
49Peroxisome_Homo sapiens_hsa041461.31266376
50Chemical carcinogenesis_Homo sapiens_hsa052041.30025411
51Pentose phosphate pathway_Homo sapiens_hsa000301.28961452
52Phenylalanine metabolism_Homo sapiens_hsa003601.23684717
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21568839
54beta-Alanine metabolism_Homo sapiens_hsa004101.20945517
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18304201
56Nucleotide excision repair_Homo sapiens_hsa034201.16960926
57Hepatitis C_Homo sapiens_hsa051601.11505344
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.09945913
59Vitamin digestion and absorption_Homo sapiens_hsa049771.09511389
60Pyruvate metabolism_Homo sapiens_hsa006201.08924037
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08568473
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08267088
63N-Glycan biosynthesis_Homo sapiens_hsa005101.05577541
64Retinol metabolism_Homo sapiens_hsa008301.05117556
65Cell cycle_Homo sapiens_hsa041101.05065015
66Galactose metabolism_Homo sapiens_hsa000520.99702533
67Arginine and proline metabolism_Homo sapiens_hsa003300.97906040
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.96089863
69Nitrogen metabolism_Homo sapiens_hsa009100.95285170
70Vitamin B6 metabolism_Homo sapiens_hsa007500.94030876
71Propanoate metabolism_Homo sapiens_hsa006400.93546978
72Homologous recombination_Homo sapiens_hsa034400.91953296
73Complement and coagulation cascades_Homo sapiens_hsa046100.90358910
74Insulin resistance_Homo sapiens_hsa049310.89321976
75Butanoate metabolism_Homo sapiens_hsa006500.87621469
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86569375
77Lysosome_Homo sapiens_hsa041420.86496767
78Tyrosine metabolism_Homo sapiens_hsa003500.85406692
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82463112
80T cell receptor signaling pathway_Homo sapiens_hsa046600.80575680
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78718107
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78497188
83p53 signaling pathway_Homo sapiens_hsa041150.77843875
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77403510
85VEGF signaling pathway_Homo sapiens_hsa043700.77023165
86PPAR signaling pathway_Homo sapiens_hsa033200.74853654
87Purine metabolism_Homo sapiens_hsa002300.74201427
88Bile secretion_Homo sapiens_hsa049760.74052823
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.73298326
90Fatty acid metabolism_Homo sapiens_hsa012120.72839049
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71861311
92Vibrio cholerae infection_Homo sapiens_hsa051100.71727755
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70353798
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69433662
95Metabolic pathways_Homo sapiens_hsa011000.67961899
96Starch and sucrose metabolism_Homo sapiens_hsa005000.67247173
97Sphingolipid metabolism_Homo sapiens_hsa006000.66642807
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66369983
99Insulin signaling pathway_Homo sapiens_hsa049100.62476138
100Chronic myeloid leukemia_Homo sapiens_hsa052200.62186164
101Endocytosis_Homo sapiens_hsa041440.61699230
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58314255
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.56496066
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56240046
105Glycerolipid metabolism_Homo sapiens_hsa005610.55846813
106Bladder cancer_Homo sapiens_hsa052190.53714539
107Apoptosis_Homo sapiens_hsa042100.53414902
108Protein export_Homo sapiens_hsa030600.52402908
109Regulation of autophagy_Homo sapiens_hsa041400.52297926
110Linoleic acid metabolism_Homo sapiens_hsa005910.50171104
111Shigellosis_Homo sapiens_hsa051310.49518291
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48293994
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.47578595
114AMPK signaling pathway_Homo sapiens_hsa041520.47379596
115B cell receptor signaling pathway_Homo sapiens_hsa046620.47346355
116RNA degradation_Homo sapiens_hsa030180.45356875
117ABC transporters_Homo sapiens_hsa020100.45147084
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44516775
119Mineral absorption_Homo sapiens_hsa049780.43104728
120Thyroid cancer_Homo sapiens_hsa052160.42723603
121Renin-angiotensin system_Homo sapiens_hsa046140.42432862
122Steroid biosynthesis_Homo sapiens_hsa001000.40707550
123Prion diseases_Homo sapiens_hsa050200.40654939
124Arachidonic acid metabolism_Homo sapiens_hsa005900.40051184
125Basal transcription factors_Homo sapiens_hsa030220.39130366
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38251037
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.38132165
128Fanconi anemia pathway_Homo sapiens_hsa034600.36923081
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36310623
130Fatty acid biosynthesis_Homo sapiens_hsa000610.35465126
131TNF signaling pathway_Homo sapiens_hsa046680.35434073
132Epstein-Barr virus infection_Homo sapiens_hsa051690.34546468
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34452756
134Non-small cell lung cancer_Homo sapiens_hsa052230.33911626
135Pancreatic cancer_Homo sapiens_hsa052120.33785076
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33075306
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.32581621
138Lysine degradation_Homo sapiens_hsa003100.31719486
139Toxoplasmosis_Homo sapiens_hsa051450.30655816
140Fatty acid elongation_Homo sapiens_hsa000620.30406952
141Ether lipid metabolism_Homo sapiens_hsa005650.29564492
142mRNA surveillance pathway_Homo sapiens_hsa030150.29393767
143Salmonella infection_Homo sapiens_hsa051320.28998315
144Systemic lupus erythematosus_Homo sapiens_hsa053220.28080292
145Tight junction_Homo sapiens_hsa045300.27534684

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