RASSF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.57172945
2L-phenylalanine catabolic process (GO:0006559)4.57172945
3paraxial mesoderm development (GO:0048339)4.36055919
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.29794420
5L-phenylalanine metabolic process (GO:0006558)4.29794420
6negative regulation of fibrinolysis (GO:0051918)4.05888552
7chondrocyte proliferation (GO:0035988)3.97864936
8peptidyl-glutamic acid carboxylation (GO:0017187)3.86884248
9protein carboxylation (GO:0018214)3.86884248
10retina vasculature morphogenesis in camera-type eye (GO:0061299)3.83330559
11endodermal cell differentiation (GO:0035987)3.82239213
12alpha-linolenic acid metabolic process (GO:0036109)3.78389510
13aromatic amino acid family catabolic process (GO:0009074)3.77076258
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.72484526
15regulation of fibrinolysis (GO:0051917)3.69931065
16mesenchymal-epithelial cell signaling (GO:0060638)3.63904543
17glyoxylate metabolic process (GO:0046487)3.61560624
18bile acid biosynthetic process (GO:0006699)3.60373276
19regulation of protein activation cascade (GO:2000257)3.60199037
20positive regulation of osteoblast proliferation (GO:0033690)3.51545254
21complement activation, alternative pathway (GO:0006957)3.49239171
22cell migration involved in sprouting angiogenesis (GO:0002042)3.47751455
23regulation of complement activation (GO:0030449)3.47336694
24plasma lipoprotein particle clearance (GO:0034381)3.46109162
25sequestering of extracellular ligand from receptor (GO:0035581)3.44967841
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.44452024
27lysine catabolic process (GO:0006554)3.34642409
28lysine metabolic process (GO:0006553)3.34642409
29axon extension involved in axon guidance (GO:0048846)3.31454593
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.31454593
31kidney mesenchyme development (GO:0072074)3.30767910
32metanephric mesenchyme development (GO:0072075)3.27758767
33cysteine metabolic process (GO:0006534)3.26838906
34kynurenine metabolic process (GO:0070189)3.24588998
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.21125754
36bone trabecula formation (GO:0060346)3.20359374
37high-density lipoprotein particle remodeling (GO:0034375)3.20304862
38cell adhesion mediated by integrin (GO:0033627)3.18369522
39sulfur amino acid catabolic process (GO:0000098)3.17560971
40low-density lipoprotein particle clearance (GO:0034383)3.14461754
41lymphangiogenesis (GO:0001946)3.13274358
42notochord development (GO:0030903)3.11787744
43fibrinolysis (GO:0042730)3.10768704
44regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.10306965
45endothelial cell morphogenesis (GO:0001886)3.09225476
46bile acid metabolic process (GO:0008206)3.07759919
47hippo signaling (GO:0035329)3.06656373
48cellular response to vitamin D (GO:0071305)3.04533949
49urea cycle (GO:0000050)3.03377129
50urea metabolic process (GO:0019627)3.03377129
51indole-containing compound catabolic process (GO:0042436)3.02448471
52indolalkylamine catabolic process (GO:0046218)3.02448471
53tryptophan catabolic process (GO:0006569)3.02448471
54amino-acid betaine metabolic process (GO:0006577)3.01490998
55positive regulation of fatty acid oxidation (GO:0046321)2.99765085
56negative chemotaxis (GO:0050919)2.99084738
57coenzyme catabolic process (GO:0009109)2.98480555
58homocysteine metabolic process (GO:0050667)2.96543589
59regulation of transforming growth factor beta2 production (GO:0032909)2.95640491
60reverse cholesterol transport (GO:0043691)2.94355981
61regulation of triglyceride catabolic process (GO:0010896)2.93736488
62substrate adhesion-dependent cell spreading (GO:0034446)2.93604901
63dicarboxylic acid biosynthetic process (GO:0043650)2.92910733
64phospholipid homeostasis (GO:0055091)2.92416371
65cellular ketone body metabolic process (GO:0046950)2.92336584
66triglyceride homeostasis (GO:0070328)2.89843420
67acylglycerol homeostasis (GO:0055090)2.89843420
68tryptophan metabolic process (GO:0006568)2.89566637
69glutamate metabolic process (GO:0006536)2.88939262
70substrate-dependent cell migration (GO:0006929)2.88100330
71tyrosine metabolic process (GO:0006570)2.86117519
72aspartate family amino acid catabolic process (GO:0009068)2.85444804
73regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.84251037
74regulation of fatty acid beta-oxidation (GO:0031998)2.83811498
75protein-lipid complex remodeling (GO:0034368)2.83524042
76macromolecular complex remodeling (GO:0034367)2.83524042
77plasma lipoprotein particle remodeling (GO:0034369)2.83524042
78negative regulation of axon extension involved in axon guidance (GO:0048843)2.82425860
79fatty acid beta-oxidation (GO:0006635)2.82408929
80positive regulation of lipid catabolic process (GO:0050996)2.80685681
81acetyl-CoA metabolic process (GO:0006084)2.76878080
82nitrogen cycle metabolic process (GO:0071941)2.76124262
83pericardium development (GO:0060039)2.75721952
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75463098
85alpha-amino acid catabolic process (GO:1901606)2.73609138
86fatty acid transmembrane transport (GO:1902001)2.72858158
87serine family amino acid catabolic process (GO:0009071)2.72155092
88fatty acid oxidation (GO:0019395)2.70535432
89regulation of plasminogen activation (GO:0010755)2.70201532
90cellular response to vitamin (GO:0071295)2.69710421
91cholesterol efflux (GO:0033344)2.68624484
92ganglion development (GO:0061548)2.67604784
93regulation of sequestering of triglyceride (GO:0010889)2.66989118
94negative regulation of protein activation cascade (GO:2000258)2.66191066
95short-chain fatty acid metabolic process (GO:0046459)2.65419792
96lipid oxidation (GO:0034440)2.65399985
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.64565926
98aromatic amino acid family metabolic process (GO:0009072)2.63781361
99glomerular basement membrane development (GO:0032836)2.63723085
100protein heterotrimerization (GO:0070208)2.63546570
101negative regulation of chondrocyte differentiation (GO:0032331)2.63153015
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63055220
103cellular glucuronidation (GO:0052695)2.61152191
104ethanol oxidation (GO:0006069)2.60927202
105epoxygenase P450 pathway (GO:0019373)2.60892648
106fatty acid catabolic process (GO:0009062)2.60295749
107cellular modified amino acid catabolic process (GO:0042219)2.60173707
108artery development (GO:0060840)2.59179011
109cellular amino acid catabolic process (GO:0009063)2.58370063
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58046716
111monocarboxylic acid catabolic process (GO:0072329)2.57245602
112anterior/posterior axis specification, embryo (GO:0008595)2.57013892
113negative regulation of lipase activity (GO:0060192)2.56287073
114plasma membrane repair (GO:0001778)2.55833070
115regulation of cholesterol homeostasis (GO:2000188)2.55777552
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55031970
117positive regulation of astrocyte differentiation (GO:0048711)2.54820465
118cardiac myofibril assembly (GO:0055003)2.53638326
119cholesterol homeostasis (GO:0042632)2.52664349
120regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.52632753
121regulation of cholesterol esterification (GO:0010872)2.52601899
122sterol homeostasis (GO:0055092)2.52473165
123ketone body metabolic process (GO:1902224)2.50610606
124regulation of fatty acid oxidation (GO:0046320)2.49634817
125vascular endothelial growth factor signaling pathway (GO:0038084)2.48854601
126axon extension (GO:0048675)2.47763388
127regulation of establishment of planar polarity (GO:0090175)2.47665592
128glomerular visceral epithelial cell development (GO:0072015)2.47582588
129response to mercury ion (GO:0046689)2.47315337
130regulation of axon extension involved in axon guidance (GO:0048841)2.46255723
131regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45729470
132protein localization to endosome (GO:0036010)2.45167282
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44899569
134collagen fibril organization (GO:0030199)2.44191639
135chondrocyte development (GO:0002063)2.43788164
136regulation of osteoblast proliferation (GO:0033688)2.43719094
137positive regulation of blood coagulation (GO:0030194)2.42457622
138positive regulation of hemostasis (GO:1900048)2.42457622
1392-oxoglutarate metabolic process (GO:0006103)2.41843725
140regulation of cholesterol metabolic process (GO:0090181)2.41700425
141carboxylic acid catabolic process (GO:0046395)2.41484206
142organic acid catabolic process (GO:0016054)2.41484206
143protein hydroxylation (GO:0018126)2.40761844
144uronic acid metabolic process (GO:0006063)2.40216226
145glucuronate metabolic process (GO:0019585)2.40216226
146righting reflex (GO:0060013)2.39599016
147lipoprotein metabolic process (GO:0042157)2.39545456
148cofactor catabolic process (GO:0051187)2.39417149
149very long-chain fatty acid metabolic process (GO:0000038)2.38830995
150apoptotic cell clearance (GO:0043277)2.34494014
151collagen metabolic process (GO:0032963)2.33908769
152convergent extension (GO:0060026)2.32110552
153negative regulation of catenin import into nucleus (GO:0035414)2.31289580
154embryonic foregut morphogenesis (GO:0048617)2.31129873
155peptidyl-proline hydroxylation (GO:0019511)2.28916705
156smooth muscle tissue development (GO:0048745)2.28468279
157wound healing, spreading of epidermal cells (GO:0035313)2.28117909
158muscle cell migration (GO:0014812)2.27847470
159regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.27699138
160short-term memory (GO:0007614)2.26375928
161negative regulation of axon guidance (GO:1902668)2.26075112
162positive regulation of p38MAPK cascade (GO:1900745)2.26040645
163skin morphogenesis (GO:0043589)2.25968244
164morphogenesis of an epithelial sheet (GO:0002011)2.25389175
165negative regulation of BMP signaling pathway (GO:0030514)2.24811024
166collagen catabolic process (GO:0030574)2.24801453
167embryonic cranial skeleton morphogenesis (GO:0048701)2.24493247
168positive regulation of catenin import into nucleus (GO:0035413)2.23619952
169mitotic cytokinesis (GO:0000281)2.23543586
170regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.20843495
171G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.20424815
172non-canonical Wnt signaling pathway (GO:0035567)2.18637215
173dorsal/ventral axis specification (GO:0009950)2.18415526
174diterpenoid biosynthetic process (GO:0016102)2.17721918
175multicellular organismal macromolecule metabolic process (GO:0044259)2.16670931
176neuron projection extension (GO:1990138)2.15751538
177embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15138102
178regulation of axon guidance (GO:1902667)2.14048785
179cytoskeleton-dependent cytokinesis (GO:0061640)2.14001724
180regulation of hippo signaling (GO:0035330)2.13665282
181axonal fasciculation (GO:0007413)2.13587200
182regulation of cardioblast differentiation (GO:0051890)2.13496441
183glomerular epithelial cell development (GO:0072310)2.12170367
184SMAD protein complex assembly (GO:0007183)2.11997795
185branching involved in salivary gland morphogenesis (GO:0060445)2.11524981
186negative regulation of hormone biosynthetic process (GO:0032353)2.10431364
187protein localization to cell surface (GO:0034394)2.09810443
188myoblast fusion (GO:0007520)2.09499946
189regulation of Rac protein signal transduction (GO:0035020)2.08901631
190mesodermal cell differentiation (GO:0048333)2.08008856
191hemidesmosome assembly (GO:0031581)2.07428838
192myofibril assembly (GO:0030239)2.07414284
193positive regulation of cardiac muscle tissue development (GO:0055025)2.06646069
194regulation of non-canonical Wnt signaling pathway (GO:2000050)2.06481567
195regulation of catenin import into nucleus (GO:0035412)2.05786100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.59467853
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.10278181
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.67166973
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58788263
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.42568265
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.98435195
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.75813642
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.64403863
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.62507215
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42237786
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39226789
12CLOCK_20551151_ChIP-Seq_293T_Human2.29534709
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19589112
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.08312918
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02745524
16* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94746309
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92391769
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81452282
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80265411
20* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76632379
21* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76632379
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73910644
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68915163
24FUS_26573619_Chip-Seq_HEK293_Human1.68537814
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.62875123
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60664952
27SMAD4_21799915_ChIP-Seq_A2780_Human1.58744765
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57874582
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57687958
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.57666394
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.55496130
32P300_19829295_ChIP-Seq_ESCs_Human1.50728646
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48551863
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46280107
35* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45783410
36AR_21909140_ChIP-Seq_LNCAP_Human1.44332941
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43620097
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40853394
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40155450
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38309834
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.37915799
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37884762
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37737188
44* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37528556
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.36499148
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36377821
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34723024
48CJUN_26792858_Chip-Seq_BT549_Human1.34274140
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33283745
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33210182
51TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31047617
52YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30983143
53TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30949741
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29627963
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.29300927
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28671662
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.28583270
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.26641464
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.26641464
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.24333146
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24179075
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.24097052
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23801714
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23801714
65TAF15_26573619_Chip-Seq_HEK293_Human1.23285103
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.22966651
67GBX2_23144817_ChIP-Seq_PC3_Human1.22825002
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22586755
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.21827674
70CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21674042
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20904583
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18036740
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17581908
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17033635
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16292039
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.15331213
77* STAT3_23295773_ChIP-Seq_U87_Human1.14541617
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.13563615
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12958917
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12912495
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12392330
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.12310773
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.11667365
84* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11207334
85EWS_26573619_Chip-Seq_HEK293_Human1.10543785
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.10222628
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10195897
88SOX9_26525672_Chip-Seq_HEART_Mouse1.10172273
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09043133
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08041108
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06945647
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06819362
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04845718
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04477600
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04438133
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04085328
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03394831
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03356671
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02828660
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02735245
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02519365
102* AHR_22903824_ChIP-Seq_MCF-7_Human1.01976890
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00821398
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00798994
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00331290
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00303490
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00076912
108* AR_25329375_ChIP-Seq_VCAP_Human0.99848270
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99675783
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99382937
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98015256
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94437467
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93542782
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90881716
115SOX2_20726797_ChIP-Seq_SW620_Human0.90507212
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90300777
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89568320
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89125883
119TP53_18474530_ChIP-ChIP_U2OS_Human0.87492120
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.85731464
121* ARNT_22903824_ChIP-Seq_MCF-7_Human0.85585133
122TP53_16413492_ChIP-PET_HCT116_Human0.85397466
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85167137
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.85110651
125DROSHA_22980978_ChIP-Seq_HELA_Human0.85086666
126HNF4A_19822575_ChIP-Seq_HepG2_Human0.85068979
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84787549
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84619134
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83566339
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83234059
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83134735
132TP63_23658742_ChIP-Seq_EP156T_Human0.82932622
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81699134
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80961376
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.80193914
136* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79641688
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.79583595
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79013479
139JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78908695
140BCAT_22108803_ChIP-Seq_LS180_Human0.78774792
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.78700271
142RXR_22108803_ChIP-Seq_LS180_Human0.77833146
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77229059
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76723099
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.74151578
146VDR_24787735_ChIP-Seq_THP-1_Human0.74078680
147BRD4_25478319_ChIP-Seq_HGPS_Human0.73843326
148* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73309527
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72450523
150CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71274153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.68448566
2MP0002139_abnormal_hepatobiliary_system4.60649764
3MP0005360_urolithiasis4.07914766
4MP0005085_abnormal_gallbladder_physiolo3.37165894
5MP0005365_abnormal_bile_salt3.20489949
6MP0003705_abnormal_hypodermis_morpholog2.78758484
7MP0009840_abnormal_foam_cell2.68909330
8MP0008875_abnormal_xenobiotic_pharmacok2.60410316
9MP0003252_abnormal_bile_duct2.57737255
10MP0003195_calcinosis2.56236400
11MP0004272_abnormal_basement_membrane2.50636653
12MP0010030_abnormal_orbit_morphology2.49392474
13MP0005275_abnormal_skin_tensile2.41809618
14MP0003941_abnormal_skin_development2.38700305
15MP0010329_abnormal_lipoprotein_level2.28396410
16MP0003806_abnormal_nucleotide_metabolis2.14590122
17MP0010352_gastrointestinal_tract_polyps2.14036970
18MP0005503_abnormal_tendon_morphology2.11323350
19MP0002837_dystrophic_cardiac_calcinosis2.09765789
20MP0005248_abnormal_Harderian_gland2.04966301
21MP0002877_abnormal_melanocyte_morpholog2.01142780
22MP0005332_abnormal_amino_acid2.00820898
23MP0005623_abnormal_meninges_morphology1.98473444
24MP0004084_abnormal_cardiac_muscle1.93776825
25MP0010368_abnormal_lymphatic_system1.77371795
26MP0003385_abnormal_body_wall1.77003711
27MP0004130_abnormal_muscle_cell1.72636132
28MP0009384_cardiac_valve_regurgitation1.70793204
29MP0003690_abnormal_glial_cell1.68852074
30MP0005670_abnormal_white_adipose1.67388352
31MP0003950_abnormal_plasma_membrane1.62633621
32MP0003279_aneurysm1.59033195
33MP0004036_abnormal_muscle_relaxation1.58107921
34MP0003937_abnormal_limbs/digits/tail_de1.57785269
35MP0000751_myopathy1.57074345
36MP0000534_abnormal_ureter_morphology1.57026324
37MP0009250_abnormal_appendicular_skeleto1.54530403
38MP0005083_abnormal_biliary_tract1.52755765
39MP0002118_abnormal_lipid_homeostasis1.52236466
40MP0001958_emphysema1.50219295
41MP0000428_abnormal_craniofacial_morphol1.46144073
42MP0003890_abnormal_embryonic-extraembry1.45576813
43MP0003191_abnormal_cellular_cholesterol1.42667009
44MP0001542_abnormal_bone_strength1.41558109
45MP0006054_spinal_hemorrhage1.41264564
46MP0003942_abnormal_urinary_system1.41208038
47MP0002295_abnormal_pulmonary_circulatio1.39578209
48MP0006138_congestive_heart_failure1.36067725
49MP0005187_abnormal_penis_morphology1.34369333
50MP0003755_abnormal_palate_morphology1.30882161
51MP0005330_cardiomyopathy1.29088994
52MP0008775_abnormal_heart_ventricle1.28252261
53MP0002697_abnormal_eye_size1.28008795
54MP0003935_abnormal_craniofacial_develop1.22167123
55MP0005666_abnormal_adipose_tissue1.20078431
56MP0003566_abnormal_cell_adhesion1.18534612
57MP0004185_abnormal_adipocyte_glucose1.18124999
58MP0000920_abnormal_myelination1.16368415
59MP0004019_abnormal_vitamin_homeostasis1.16339732
60MP0002233_abnormal_nose_morphology1.16290636
61MP0000013_abnormal_adipose_tissue1.14389200
62MP0004087_abnormal_muscle_fiber1.14148984
63MP0000432_abnormal_head_morphology1.14006281
64MP0002108_abnormal_muscle_morphology1.13152061
65MP0000762_abnormal_tongue_morphology1.11269646
66MP0000609_abnormal_liver_physiology1.10926893
67MP0005451_abnormal_body_composition1.10913698
68MP0005058_abnormal_lysosome_morphology1.10048670
69MP0003011_delayed_dark_adaptation1.08871098
70MP0000749_muscle_degeneration1.08098260
71MP0000747_muscle_weakness1.06490316
72MP0002168_other_aberrant_phenotype1.05829226
73MP0000462_abnormal_digestive_system1.05425888
74MP0000569_abnormal_digit_pigmentation1.05271107
75MP0005319_abnormal_enzyme/_coenzyme1.03697261
76MP0001666_abnormal_nutrient_absorption1.02300573
77MP0005375_adipose_tissue_phenotype1.01709529
78MP0001544_abnormal_cardiovascular_syste1.01055916
79MP0005385_cardiovascular_system_phenoty1.01055916
80MP0002896_abnormal_bone_mineralization1.00923158
81MP0001661_extended_life_span1.00774685
82MP0002972_abnormal_cardiac_muscle1.00393577
83MP0005257_abnormal_intraocular_pressure0.97519447
84MP0001293_anophthalmia0.97208724
85MP0005620_abnormal_muscle_contractility0.96639602
86MP0000537_abnormal_urethra_morphology0.95450347
87MP0005595_abnormal_vascular_smooth0.94763086
88MP0000778_abnormal_nervous_system0.94662931
89MP0000604_amyloidosis0.94442201
90MP0001286_abnormal_eye_development0.94270290
91MP0000003_abnormal_adipose_tissue0.93441110
92MP0003878_abnormal_ear_physiology0.93330338
93MP0005377_hearing/vestibular/ear_phenot0.93330338
94MP0010630_abnormal_cardiac_muscle0.92700061
95MP0002971_abnormal_brown_adipose0.91549191
96MP0000767_abnormal_smooth_muscle0.90903001
97MP0003091_abnormal_cell_migration0.89829431
98MP0004215_abnormal_myocardial_fiber0.89530030
99MP0002938_white_spotting0.88986492
100MP0002084_abnormal_developmental_patter0.87988501
101MP0002092_abnormal_eye_morphology0.87515091
102MP0002060_abnormal_skin_morphology0.87179605
103MP0010386_abnormal_urinary_bladder0.85885473
104MP0001299_abnormal_eye_distance/0.85521612
105MP0000750_abnormal_muscle_regeneration0.84981801
106MP0002269_muscular_atrophy0.84781332
107MP0004233_abnormal_muscle_weight0.83999459
108MP0009643_abnormal_urine_homeostasis0.83896541
109MP0000049_abnormal_middle_ear0.83882445
110MP0004134_abnormal_chest_morphology0.83511884
111MP0003329_amyloid_beta_deposits0.83154035
112MP0003045_fibrosis0.82632955
113MP0005193_abnormal_anterior_eye0.82506209
114MP0002128_abnormal_blood_circulation0.82204136
115MP0005023_abnormal_wound_healing0.81022206
116MP0009780_abnormal_chondrocyte_physiolo0.80777930
117MP0002090_abnormal_vision0.80546186
118MP0001915_intracranial_hemorrhage0.80329710
119MP0005408_hypopigmentation0.80268590
120MP0005508_abnormal_skeleton_morphology0.78495834
121MP0005164_abnormal_response_to0.78320647
122MP0001879_abnormal_lymphatic_vessel0.77796025
123MP0003119_abnormal_digestive_system0.76634506
124MP0002102_abnormal_ear_morphology0.76268095
125MP0008004_abnormal_stomach_pH0.76191607
126MP0002116_abnormal_craniofacial_bone0.75982114
127MP0005584_abnormal_enzyme/coenzyme_acti0.75713171
128MP0002109_abnormal_limb_morphology0.75517265
129MP0002184_abnormal_innervation0.75212243
130MP0003115_abnormal_respiratory_system0.75085028
131MP0005334_abnormal_fat_pad0.74466698
132MP0000733_abnormal_muscle_development0.73723493
133MP0005197_abnormal_uvea_morphology0.73551339
134MP0002925_abnormal_cardiovascular_devel0.73190669
135MP0002114_abnormal_axial_skeleton0.71987570
136MP0000230_abnormal_systemic_arterial0.70006279
137MP0003136_yellow_coat_color0.69887966
138MP0003137_abnormal_impulse_conducting0.69691151
139MP0009053_abnormal_anal_canal0.69465172
140MP0003646_muscle_fatigue0.68632689
141MP0003300_gastrointestinal_ulcer0.68587646
142MP0004858_abnormal_nervous_system0.68506965
143MP0000759_abnormal_skeletal_muscle0.68502015
144MP0002115_abnormal_skeleton_extremities0.68253849
145MP0004085_abnormal_heartbeat0.67977830
146MP0002234_abnormal_pharynx_morphology0.67433893
147MP0001756_abnormal_urination0.67183347
148MP0000163_abnormal_cartilage_morphology0.67142800
149MP0001177_atelectasis0.67019905
150MP0003868_abnormal_feces_composition0.66523104
151MP0004484_altered_response_of0.64991094
152MP0005171_absent_coat_pigmentation0.64252228
153MP0005167_abnormal_blood-brain_barrier0.64111785
154MP0003634_abnormal_glial_cell0.62793376

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.35512144
2Premature rupture of membranes (HP:0001788)4.61978544
3Xanthomatosis (HP:0000991)4.45909835
4Intrahepatic cholestasis (HP:0001406)4.40756870
5Protrusio acetabuli (HP:0003179)3.92477817
6Hyperlipoproteinemia (HP:0010980)3.83668964
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.71457042
8Complement deficiency (HP:0004431)3.47814339
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.32680063
10Aortic aneurysm (HP:0004942)3.26089816
11Overgrowth (HP:0001548)3.24083259
12Broad metatarsal (HP:0001783)3.21899788
13Hypoalphalipoproteinemia (HP:0003233)3.21031769
14Vascular tortuosity (HP:0004948)3.13608769
15Arterial tortuosity (HP:0005116)3.11290497
16Prolonged partial thromboplastin time (HP:0003645)3.10312074
17Skin nodule (HP:0200036)3.04983606
18Epidermoid cyst (HP:0200040)2.99896818
19Abnormality of the common coagulation pathway (HP:0010990)2.84925866
20Myocardial infarction (HP:0001658)2.84925364
21Hypolipoproteinemia (HP:0010981)2.81153266
22Hypoglycemic coma (HP:0001325)2.79752787
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79423170
24Ketosis (HP:0001946)2.74341380
25Hypobetalipoproteinemia (HP:0003563)2.71781527
26Syringomyelia (HP:0003396)2.68516239
27Spinal cord lesions (HP:0100561)2.68516239
28Hyperammonemia (HP:0001987)2.68113333
29Neonatal short-limb short stature (HP:0008921)2.67466251
30Hyperglycinemia (HP:0002154)2.65075213
31Shallow orbits (HP:0000586)2.64045230
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63584124
33Ankle contracture (HP:0006466)2.61788874
34Abnormality of glycine metabolism (HP:0010895)2.58485315
35Abnormality of serine family amino acid metabolism (HP:0010894)2.58485315
36Turricephaly (HP:0000262)2.58244453
37Hyporeflexia of lower limbs (HP:0002600)2.55835608
38Vertebral compression fractures (HP:0002953)2.52925476
39Absent frontal sinuses (HP:0002688)2.52167504
40Right ventricular cardiomyopathy (HP:0011663)2.51630862
41Joint hemorrhage (HP:0005261)2.51170255
42Peritonitis (HP:0002586)2.50119214
43Muscle fiber splitting (HP:0003555)2.49762037
44Abnormality of complement system (HP:0005339)2.45314404
45Mitral stenosis (HP:0001718)2.44935438
46Increased connective tissue (HP:0009025)2.43438270
47Aortic dissection (HP:0002647)2.43275633
48Focal segmental glomerulosclerosis (HP:0000097)2.42515983
49Hypoplasia of the iris (HP:0007676)2.37927815
50Hyperglycinuria (HP:0003108)2.37017237
51Cerebral aneurysm (HP:0004944)2.34776762
52Wormian bones (HP:0002645)2.33543043
53Abnormality of methionine metabolism (HP:0010901)2.32832446
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32229993
55Abnormality of fatty-acid metabolism (HP:0004359)2.30869310
56Ketoacidosis (HP:0001993)2.30624247
57Abnormality of the intrinsic pathway (HP:0010989)2.29460163
58Cardiovascular calcification (HP:0011915)2.28213533
59Limited hip movement (HP:0008800)2.25159304
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.24958497
61Hypercholesterolemia (HP:0003124)2.24040476
62Axonal loss (HP:0003447)2.21826498
63Fat malabsorption (HP:0002630)2.20400492
64Mildly elevated creatine phosphokinase (HP:0008180)2.13330418
65Sudden death (HP:0001699)2.11831177
66Follicular hyperkeratosis (HP:0007502)2.10133478
67Type 1 muscle fiber predominance (HP:0003803)2.09944251
68Mitral valve prolapse (HP:0001634)2.09775761
69Coronal craniosynostosis (HP:0004440)2.09399806
70Increased variability in muscle fiber diameter (HP:0003557)2.08392177
71Glomerulosclerosis (HP:0000096)2.07861479
72Lymphangioma (HP:0100764)2.07616678
73Hypopigmentation of the fundus (HP:0007894)2.06943211
74Exercise-induced muscle cramps (HP:0003710)2.06062689
75Biconcave vertebral bodies (HP:0004586)2.05703467
76Spondylolisthesis (HP:0003302)2.01804218
77Infantile muscular hypotonia (HP:0008947)2.01718608
78Atrophic scars (HP:0001075)2.01327032
79Hydroxyprolinuria (HP:0003080)2.00145839
80Abnormality of proline metabolism (HP:0010907)2.00145839
81Bowel diverticulosis (HP:0005222)1.99852423
82Short nail (HP:0001799)1.99302860
83Slender build (HP:0001533)1.98288092
84Blue sclerae (HP:0000592)1.97585286
85Soft skin (HP:0000977)1.97149382
86Vascular calcification (HP:0004934)1.96430511
87Genu recurvatum (HP:0002816)1.93894958
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93345402
89Hepatocellular carcinoma (HP:0001402)1.92898909
90Alopecia of scalp (HP:0002293)1.92139544
91Knee flexion contracture (HP:0006380)1.91391119
92Hip contracture (HP:0003273)1.91318982
93Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.90686619
94Neurofibrillary tangles (HP:0002185)1.90506819
95Fragile skin (HP:0001030)1.90031906
96Cervical subluxation (HP:0003308)1.89513998
97Thoracolumbar scoliosis (HP:0002944)1.89004735
98Aneurysm (HP:0002617)1.86897647
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85856660
100Spinal rigidity (HP:0003306)1.85749861
101Bladder diverticulum (HP:0000015)1.85725168
102Nemaline bodies (HP:0003798)1.85469734
103Esophageal varix (HP:0002040)1.84250580
104Vertebral arch anomaly (HP:0008438)1.83913908
105Abnormality of the fovea (HP:0000493)1.83639931
106Abnormality of the Achilles tendon (HP:0005109)1.83527821
107Muscle fiber inclusion bodies (HP:0100299)1.82942268
108Nephritis (HP:0000123)1.82888730
109Choroideremia (HP:0001139)1.82812160
110Pulmonic stenosis (HP:0001642)1.82609130
111Abnormal delivery (HP:0001787)1.82257339
112Limb-girdle muscle weakness (HP:0003325)1.81937459
113Hyperglycemia (HP:0003074)1.80918698
114Hepatoblastoma (HP:0002884)1.80213522
115Abnormality of the acetabulum (HP:0003170)1.80034158
116Elbow flexion contracture (HP:0002987)1.79460474
117Abnormal gallbladder morphology (HP:0012437)1.77433260
118Back pain (HP:0003418)1.77190359
119Sensorimotor neuropathy (HP:0007141)1.76736885
120Cerebral inclusion bodies (HP:0100314)1.75464779
121Cholelithiasis (HP:0001081)1.74421147
122Wrist flexion contracture (HP:0001239)1.74291073
123Osteolytic defects of the hand bones (HP:0009699)1.73839391
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.73839391
125Lipoatrophy (HP:0100578)1.73367456
126Round ear (HP:0100830)1.73071638
127Bell-shaped thorax (HP:0001591)1.72691825
128Abnormal cartilage morphology (HP:0002763)1.72069118
129Wide anterior fontanel (HP:0000260)1.71403928
130Hypoglycemic seizures (HP:0002173)1.71332941
131Cubitus valgus (HP:0002967)1.70845733
132Hypoventilation (HP:0002791)1.70247157
133Conjugated hyperbilirubinemia (HP:0002908)1.69891425
134Abnormality of dentin (HP:0010299)1.69887867
135Joint laxity (HP:0001388)1.69887405
136Ulnar bowing (HP:0003031)1.69724009
137Natal tooth (HP:0000695)1.68906018
138Abnormality of the ischium (HP:0003174)1.68320217
139Mitral regurgitation (HP:0001653)1.68080230
140Calcaneovalgus deformity (HP:0001848)1.67598493
141Renal duplication (HP:0000075)1.67492173
142Disproportionate tall stature (HP:0001519)1.67395897
143Abnormal pancreas size (HP:0012094)1.67234034
144Myoglobinuria (HP:0002913)1.66864045
145Hyperextensible skin (HP:0000974)1.66721098
146Hypoplastic ischia (HP:0003175)1.66122068
147Abnormality of skeletal muscle fiber size (HP:0012084)1.64920826
148Abnormality of the calf musculature (HP:0001430)1.63424857
149Aortic regurgitation (HP:0001659)1.61637245
150Abnormality of the frontal sinuses (HP:0002687)1.58170216
151Mild short stature (HP:0003502)1.55472762
152Deformed tarsal bones (HP:0008119)1.54135048
153Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.53955086
154Ectopia lentis (HP:0001083)1.53790650
155Aplasia involving bones of the upper limbs (HP:0009823)1.53447811
156Aplasia of the phalanges of the hand (HP:0009802)1.53447811
157Aplasia involving bones of the extremities (HP:0009825)1.53447811
158Papillary thyroid carcinoma (HP:0002895)1.52721157
159Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.51422986
160Arnold-Chiari malformation (HP:0002308)1.50103334
161Scotoma (HP:0000575)1.49496301
162Flat cornea (HP:0007720)1.48826305
163Bifid tongue (HP:0010297)1.48722909
164Broad long bones (HP:0005622)1.48619126
165Preaxial foot polydactyly (HP:0001841)1.47456000
166Mesomelia (HP:0003027)1.46742153
167Long toe (HP:0010511)1.45864989
168Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.44984261
169Deviation of the hallux (HP:0010051)1.43831104
170Delayed cranial suture closure (HP:0000270)1.43150311
171Round face (HP:0000311)1.42825264
172Abnormality of the calcaneus (HP:0008364)1.42471167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.60160041
2TRIB33.09036664
3SIK12.79207191
4TTN2.74529717
5PDGFRA2.51866705
6STK392.42711020
7DDR22.35146949
8PKN22.33068012
9AKT32.17569168
10BCKDK2.04853837
11EPHB11.88657926
12MET1.82638065
13RIPK11.75270090
14WNK41.75261857
15PRPF4B1.72743455
16ERN11.70063810
17TIE11.56412839
18PNCK1.56198947
19LATS21.53940540
20PAK31.51922372
21OXSR11.48967768
22BMX1.43489428
23ERBB41.41704828
24CAMK1D1.41625784
25WNK11.39844098
26ERBB31.36413927
27FGFR41.34634599
28PTK61.34560297
29INSRR1.32603843
30FGFR21.29213589
31DMPK1.28313855
32EPHA31.24755601
33ICK1.22109190
34PBK1.22028026
35MKNK21.21540655
36STK31.21248388
37MYLK1.20679617
38MOS1.19843188
39PTK21.16745368
40OBSCN1.16211420
41BRSK21.14137966
42LIMK11.13979467
43FER1.13902256
44TRPM71.11346614
45PAK61.10777919
46ABL21.09544349
47CASK1.09086732
48PDGFRB1.07624905
49CAMK1G1.06086721
50PRKD11.05237860
51EPHB21.04434596
52MAP3K41.03290114
53PAK21.03216342
54NUAK11.02757071
55PIK3CA1.00420017
56STK38L0.97851944
57MST1R0.93750720
58PDPK10.92205519
59LMTK20.92155892
60PDK20.91739487
61NEK90.91315231
62PKN10.90828536
63PHKG10.90581240
64PHKG20.90581240
65TGFBR20.90527457
66PTK2B0.89738557
67STK240.89541736
68ROCK10.89233244
69MKNK10.89015261
70NTRK10.86924931
71PINK10.86595801
72SGK2230.83377955
73SGK4940.83377955
74CAMK2D0.82863555
75EPHA40.82112348
76BMPR1B0.82049931
77RET0.81731730
78GSK3A0.81326366
79MAP3K90.80108971
80PRKAA20.79414620
81ROCK20.78369356
82PRKCH0.77809902
83MTOR0.77294348
84PLK20.74971874
85EIF2AK30.73451048
86FGFR10.71776301
87MARK10.71508130
88MAP2K10.69992381
89SCYL20.69976198
90PRKCE0.69179848
91MAP3K120.68954229
92SGK30.68069443
93TGFBR10.64529197
94CAMK2G0.64214624
95MAP2K70.62843004
96MAPK70.62216083
97FLT30.62068438
98TTK0.61214433
99JAK10.60454252
100PDK30.60240253
101PDK40.60240253
102WEE10.59300261
103STK380.59288948
104MAP3K30.58986196
105MELK0.58825329
106BRD40.58757768
107MAP2K40.58198676
108MAP3K20.57464594
109FRK0.56908743
110MAP3K70.56737399
111CDC42BPA0.56609907
112NEK10.52013287
113PLK30.50217436
114CSNK1G10.50166157
115KSR20.49762142
116CSNK1A1L0.49645023
117EEF2K0.49595435
118PAK40.49484422
119CAMK2B0.49025214
120KSR10.48955674
121BCR0.48507217
122EPHA20.48001915
123TSSK60.45677167
124MAP3K10.44012159
125TAOK30.43715777
126ILK0.43038781
127PRKAA10.41979422
128PRKD30.41366674
129CAMK2A0.41238940
130WNK30.41046216
131SGK20.39740970
132PRKACG0.39511815
133TNIK0.39428800
134PRKACB0.38910413
135INSR0.38433100
136BRSK10.37703453
137NEK20.35303589
138PLK10.34074437
139BRAF0.31426019

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.37081726
2Nitrogen metabolism_Homo sapiens_hsa009103.21618914
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83289351
4Arginine biosynthesis_Homo sapiens_hsa002202.53039718
5Fatty acid degradation_Homo sapiens_hsa000712.48335165
6Complement and coagulation cascades_Homo sapiens_hsa046102.41900265
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39989156
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39159406
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32705370
10Hippo signaling pathway_Homo sapiens_hsa043902.19760794
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17335837
12Tryptophan metabolism_Homo sapiens_hsa003802.14379060
13Propanoate metabolism_Homo sapiens_hsa006402.14049987
14Butanoate metabolism_Homo sapiens_hsa006502.11360762
15PPAR signaling pathway_Homo sapiens_hsa033202.08549553
16Basal cell carcinoma_Homo sapiens_hsa052171.96362637
17Fatty acid metabolism_Homo sapiens_hsa012121.95699110
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92889873
19TGF-beta signaling pathway_Homo sapiens_hsa043501.82274650
20Hedgehog signaling pathway_Homo sapiens_hsa043401.78371926
21Peroxisome_Homo sapiens_hsa041461.64797515
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63870727
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61713450
24Melanoma_Homo sapiens_hsa052181.59635946
25Histidine metabolism_Homo sapiens_hsa003401.57746684
26Small cell lung cancer_Homo sapiens_hsa052221.55248712
27Wnt signaling pathway_Homo sapiens_hsa043101.53400136
28Fatty acid elongation_Homo sapiens_hsa000621.52308029
29Bile secretion_Homo sapiens_hsa049761.50560997
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50004677
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49054017
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48258584
33beta-Alanine metabolism_Homo sapiens_hsa004101.46838791
34Circadian rhythm_Homo sapiens_hsa047101.45881628
35MicroRNAs in cancer_Homo sapiens_hsa052061.43497329
36Melanogenesis_Homo sapiens_hsa049161.41765333
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35979290
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34323515
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.33854104
40Chemical carcinogenesis_Homo sapiens_hsa052041.30566033
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29320374
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29274523
43ECM-receptor interaction_Homo sapiens_hsa045121.29235353
44Sulfur metabolism_Homo sapiens_hsa009201.27388703
45Steroid biosynthesis_Homo sapiens_hsa001001.26673228
46Caffeine metabolism_Homo sapiens_hsa002321.25842547
47Retinol metabolism_Homo sapiens_hsa008301.25794185
48Pyruvate metabolism_Homo sapiens_hsa006201.22633102
49Staphylococcus aureus infection_Homo sapiens_hsa051501.20221780
50Pathways in cancer_Homo sapiens_hsa052001.18938054
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18937353
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17419932
53Phenylalanine metabolism_Homo sapiens_hsa003601.16050156
54Gap junction_Homo sapiens_hsa045401.14487001
55Starch and sucrose metabolism_Homo sapiens_hsa005001.13823706
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11922753
57Dorso-ventral axis formation_Homo sapiens_hsa043201.11613109
58Tyrosine metabolism_Homo sapiens_hsa003501.06924897
59Carbon metabolism_Homo sapiens_hsa012001.05913173
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04833236
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04671507
62Arginine and proline metabolism_Homo sapiens_hsa003301.02572811
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98417564
64Glioma_Homo sapiens_hsa052140.97287983
65ABC transporters_Homo sapiens_hsa020100.92114935
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91088669
67Dilated cardiomyopathy_Homo sapiens_hsa054140.89504009
68Lysine degradation_Homo sapiens_hsa003100.89399273
69Fat digestion and absorption_Homo sapiens_hsa049750.88582281
70Vitamin B6 metabolism_Homo sapiens_hsa007500.88288366
71Thyroid cancer_Homo sapiens_hsa052160.88215522
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87191174
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86463191
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86435930
75Long-term depression_Homo sapiens_hsa047300.85879927
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85563234
77Rap1 signaling pathway_Homo sapiens_hsa040150.84754103
78Selenocompound metabolism_Homo sapiens_hsa004500.84616650
79Ras signaling pathway_Homo sapiens_hsa040140.83649533
80Glycerolipid metabolism_Homo sapiens_hsa005610.82116380
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80164178
82ErbB signaling pathway_Homo sapiens_hsa040120.80150840
83Focal adhesion_Homo sapiens_hsa045100.79003347
84Glutamatergic synapse_Homo sapiens_hsa047240.77417996
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76550309
86p53 signaling pathway_Homo sapiens_hsa041150.76354143
87Endometrial cancer_Homo sapiens_hsa052130.76232455
88Prostate cancer_Homo sapiens_hsa052150.74639168
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73964130
90Biosynthesis of amino acids_Homo sapiens_hsa012300.73283924
91Amoebiasis_Homo sapiens_hsa051460.73132261
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71974811
93Fatty acid biosynthesis_Homo sapiens_hsa000610.70574762
94Colorectal cancer_Homo sapiens_hsa052100.70269917
95Inositol phosphate metabolism_Homo sapiens_hsa005620.69863457
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.68746040
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.66392570
98Oxytocin signaling pathway_Homo sapiens_hsa049210.65798709
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65737751
100Circadian entrainment_Homo sapiens_hsa047130.64447891
101Thyroid hormone synthesis_Homo sapiens_hsa049180.64300283
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63687815
103Renin secretion_Homo sapiens_hsa049240.63416199
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63035059
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62921792
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62428410
107FoxO signaling pathway_Homo sapiens_hsa040680.62015399
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.61864114
109Dopaminergic synapse_Homo sapiens_hsa047280.61453552
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.61037796
111Gastric acid secretion_Homo sapiens_hsa049710.60164065
112Calcium signaling pathway_Homo sapiens_hsa040200.59466379
113Insulin resistance_Homo sapiens_hsa049310.59392085
114Protein digestion and absorption_Homo sapiens_hsa049740.58487806
115Cell cycle_Homo sapiens_hsa041100.58202953
116mTOR signaling pathway_Homo sapiens_hsa041500.57243835
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55936075
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55676948
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55636421
120Prion diseases_Homo sapiens_hsa050200.55597376
121Non-homologous end-joining_Homo sapiens_hsa034500.55082111
122cAMP signaling pathway_Homo sapiens_hsa040240.54244705
123Vitamin digestion and absorption_Homo sapiens_hsa049770.53067701
124Insulin secretion_Homo sapiens_hsa049110.53044283
125MAPK signaling pathway_Homo sapiens_hsa040100.52499018
126Morphine addiction_Homo sapiens_hsa050320.52019591
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51130143
128Estrogen signaling pathway_Homo sapiens_hsa049150.51016569
129Proteoglycans in cancer_Homo sapiens_hsa052050.50617526
130Choline metabolism in cancer_Homo sapiens_hsa052310.48993565
131Serotonergic synapse_Homo sapiens_hsa047260.47733778
132GABAergic synapse_Homo sapiens_hsa047270.47451968
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47284521
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46984209
135Lysosome_Homo sapiens_hsa041420.46903187
136Long-term potentiation_Homo sapiens_hsa047200.46680169
137Cholinergic synapse_Homo sapiens_hsa047250.46502184
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46259837
139Ovarian steroidogenesis_Homo sapiens_hsa049130.43717706
140Chronic myeloid leukemia_Homo sapiens_hsa052200.43021609
141Pancreatic cancer_Homo sapiens_hsa052120.42294303
142AMPK signaling pathway_Homo sapiens_hsa041520.40300415
143Tight junction_Homo sapiens_hsa045300.32996518
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.32623289
145Glutathione metabolism_Homo sapiens_hsa004800.30659506
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.30270385
147Adherens junction_Homo sapiens_hsa045200.30220495
148Renal cell carcinoma_Homo sapiens_hsa052110.29992998
149Axon guidance_Homo sapiens_hsa043600.28301509
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28032200
151Glucagon signaling pathway_Homo sapiens_hsa049220.26966948
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25911706
153Malaria_Homo sapiens_hsa051440.25564151
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23987935
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.23986328
156Insulin signaling pathway_Homo sapiens_hsa049100.23840813
157Phagosome_Homo sapiens_hsa041450.23678310
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21782231
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21121237
160Folate biosynthesis_Homo sapiens_hsa007900.20404699
161Bladder cancer_Homo sapiens_hsa052190.19238824
162Metabolic pathways_Homo sapiens_hsa011000.19148177
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.18223520
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17572705
165Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17408161
166Type II diabetes mellitus_Homo sapiens_hsa049300.16497079
167Linoleic acid metabolism_Homo sapiens_hsa005910.16238704
168Central carbon metabolism in cancer_Homo sapiens_hsa052300.14421954

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