RASSF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.33086109
2endothelium development (GO:0003158)7.41140354
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.30911433
4axoneme assembly (GO:0035082)6.05743347
5surfactant homeostasis (GO:0043129)5.67996744
6positive regulation of vasculogenesis (GO:2001214)5.42763488
7regulation of vasculogenesis (GO:2001212)5.23670640
8vascular endothelial growth factor signaling pathway (GO:0038084)5.23348367
9peptidyl-tyrosine autophosphorylation (GO:0038083)5.15025100
10endothelial cell differentiation (GO:0045446)4.94873669
11lymphangiogenesis (GO:0001946)4.83500739
12regulation of cilium movement (GO:0003352)4.80694354
13motile cilium assembly (GO:0044458)4.75128076
14embryonic heart tube development (GO:0035050)4.72536096
15transcytosis (GO:0045056)4.46791388
16chemical homeostasis within a tissue (GO:0048875)4.45373757
17hemidesmosome assembly (GO:0031581)4.39024636
18intraciliary transport (GO:0042073)4.37056592
19regulation of endothelial cell differentiation (GO:0045601)4.31186312
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.20676542
21sodium-independent organic anion transport (GO:0043252)4.18752075
22vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.14286799
23cilium organization (GO:0044782)4.12303822
24Notch signaling involved in heart development (GO:0061314)4.07690951
25cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.99032158
26cilium assembly (GO:0042384)3.89681808
27retinal cone cell development (GO:0046549)3.87691426
28left/right axis specification (GO:0070986)3.86568886
29cell migration involved in sprouting angiogenesis (GO:0002042)3.81523841
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.75454071
31blood vessel endothelial cell migration (GO:0043534)3.74408530
32lateral sprouting from an epithelium (GO:0060601)3.74141221
33cilium morphogenesis (GO:0060271)3.73876521
34negative regulation of keratinocyte proliferation (GO:0010839)3.71774358
35protein-cofactor linkage (GO:0018065)3.71063506
36ovulation from ovarian follicle (GO:0001542)3.66916347
37blood vessel maturation (GO:0001955)3.62943829
38glomerular filtration (GO:0003094)3.55564731
39renal filtration (GO:0097205)3.54206337
40lung lobe morphogenesis (GO:0060463)3.53635977
41patterning of blood vessels (GO:0001569)3.53400500
42negative regulation of cell fate specification (GO:0009996)3.53340418
43cornea development in camera-type eye (GO:0061303)3.48709977
44platelet dense granule organization (GO:0060155)3.46045346
45response to pheromone (GO:0019236)3.44908480
46ventricular system development (GO:0021591)3.42807239
47desmosome organization (GO:0002934)3.40703597
48heart trabecula formation (GO:0060347)3.39497064
49left/right pattern formation (GO:0060972)3.33331538
50vasculogenesis (GO:0001570)3.31208950
51endothelial tube morphogenesis (GO:0061154)3.28480503
52morphogenesis of an endothelium (GO:0003159)3.28480503
53cellular component assembly involved in morphogenesis (GO:0010927)3.26970706
54nucleotide transmembrane transport (GO:1901679)3.25560157
55ventricular trabecula myocardium morphogenesis (GO:0003222)3.22288390
56microtubule bundle formation (GO:0001578)3.20995201
57neural crest cell development (GO:0014032)3.20604361
58cell surface receptor signaling pathway involved in heart development (GO:0061311)3.19983605
59positive regulation of odontogenesis (GO:0042482)3.15973921
60glomerular epithelial cell development (GO:0072310)3.11515751
61protein localization to cilium (GO:0061512)3.10388419
62cilium movement (GO:0003341)3.08965666
63endothelial cell morphogenesis (GO:0001886)3.08197071
64regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.06714975
65photoreceptor cell maintenance (GO:0045494)3.06387251
66fucose catabolic process (GO:0019317)3.05664065
67L-fucose metabolic process (GO:0042354)3.05664065
68L-fucose catabolic process (GO:0042355)3.05664065
69retinal rod cell development (GO:0046548)3.05416077
70embryonic foregut morphogenesis (GO:0048617)3.03648736
71heart trabecula morphogenesis (GO:0061384)3.03246270
72lung vasculature development (GO:0060426)3.02930588
73nonmotile primary cilium assembly (GO:0035058)3.02393193
74behavioral response to nicotine (GO:0035095)3.00895281
75phasic smooth muscle contraction (GO:0014821)2.97321949
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96020999
77artery development (GO:0060840)2.93471294
78protein localization to cell surface (GO:0034394)2.87811974
79mesenchymal cell development (GO:0014031)2.87162639
80regulation of cardioblast proliferation (GO:0003264)2.85468947
81regulation of secondary heart field cardioblast proliferation (GO:0003266)2.85468947
82mRNA transcription from RNA polymerase II promoter (GO:0042789)2.84689368
83establishment of endothelial barrier (GO:0061028)2.83867264
84layer formation in cerebral cortex (GO:0021819)2.83382747
85rRNA catabolic process (GO:0016075)2.81004987
86one-carbon compound transport (GO:0019755)2.80183909
87trabecula morphogenesis (GO:0061383)2.79708897
88inner ear receptor stereocilium organization (GO:0060122)2.78390407
89regulation of cell fate specification (GO:0042659)2.77683287
90positive regulation of cell junction assembly (GO:1901890)2.77366162
91positive regulation of focal adhesion assembly (GO:0051894)2.77366162
92regulation of cardioblast differentiation (GO:0051890)2.76037580
93renal system development (GO:0072001)2.75766380
94organ formation (GO:0048645)2.75681802
95neural tube formation (GO:0001841)2.75295190
96monocyte differentiation (GO:0030224)2.74976577
97regulation of microtubule-based movement (GO:0060632)2.74438788
98calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.74170459
99limb bud formation (GO:0060174)2.74052912
100ectoderm development (GO:0007398)2.73558117
101protein import into peroxisome matrix (GO:0016558)2.73523295
102establishment of tissue polarity (GO:0007164)2.71297914
103establishment of planar polarity (GO:0001736)2.71297914
104mesodermal cell differentiation (GO:0048333)2.70904662
105nephron epithelium morphogenesis (GO:0072088)2.70797370
106nephron tubule morphogenesis (GO:0072078)2.70797370
107regulation of action potential (GO:0098900)2.70356252
108trabecula formation (GO:0060343)2.67397246
109cell projection assembly (GO:0030031)2.67347313
110protein polyglutamylation (GO:0018095)2.67155833
111germ cell migration (GO:0008354)2.66056906
112glomerular visceral epithelial cell development (GO:0072015)2.65912795
113axonemal dynein complex assembly (GO:0070286)2.64545472
114regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.62808926
115histamine secretion (GO:0001821)2.62166677
116cilium or flagellum-dependent cell motility (GO:0001539)2.61873168
117exogenous drug catabolic process (GO:0042738)2.60852436
118cardiac muscle cell proliferation (GO:0060038)2.60754320
119DNA deamination (GO:0045006)2.59063329
120determination of left/right symmetry (GO:0007368)2.58898827
121maturation of 5.8S rRNA (GO:0000460)2.58722790
122mRNA transcription (GO:0009299)2.57763512
123sprouting angiogenesis (GO:0002040)2.57496115
124positive regulation of endothelial cell differentiation (GO:0045603)2.57463317
125keratinocyte development (GO:0003334)2.56378619
126water-soluble vitamin biosynthetic process (GO:0042364)2.56150709
127regulation of hippo signaling (GO:0035330)2.55801819
128Notch receptor processing (GO:0007220)2.54460979
129negative regulation of telomere maintenance (GO:0032205)2.54154421
130smoothened signaling pathway (GO:0007224)2.54111487
131vitamin transmembrane transport (GO:0035461)2.54103615
132epithelial cilium movement (GO:0003351)2.53658306
133negative regulation of cell fate commitment (GO:0010454)2.53451141
134heart valve morphogenesis (GO:0003179)2.53113894
135stem cell development (GO:0048864)2.52768317
136aorta morphogenesis (GO:0035909)2.52753127
137photoreceptor cell development (GO:0042461)2.51993895
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.51626887
139morphogenesis of an epithelial sheet (GO:0002011)2.51372820
140blood vessel remodeling (GO:0001974)2.51123178
141negative regulation of stem cell proliferation (GO:2000647)2.49973793
142negative regulation of Rho protein signal transduction (GO:0035024)2.49545874
143thyroid hormone generation (GO:0006590)2.49208673
144auditory receptor cell stereocilium organization (GO:0060088)2.48943131
145reflex (GO:0060004)2.48563320
146positive regulation of respiratory burst (GO:0060267)2.47593430
147determination of bilateral symmetry (GO:0009855)2.47426582
148positive regulation of keratinocyte differentiation (GO:0045618)2.47338533
149positive regulation of action potential (GO:0045760)2.47243978
150terpenoid biosynthetic process (GO:0016114)2.45393398
151regulation of mesenchymal cell proliferation (GO:0010464)2.45141168
152protein kinase C signaling (GO:0070528)2.45084429
153negative regulation of neurological system process (GO:0031645)2.44858828
154cellular ketone body metabolic process (GO:0046950)2.44792279
155renal absorption (GO:0070293)2.44717416
156positive regulation of adherens junction organization (GO:1903393)2.44518518
157thyroid hormone metabolic process (GO:0042403)2.43884050
158basement membrane organization (GO:0071711)2.43845635
159ubiquinone biosynthetic process (GO:0006744)2.43235710
160blood vessel morphogenesis (GO:0048514)2.43228145
161adhesion of symbiont to host (GO:0044406)2.42796097
162regulation of positive chemotaxis (GO:0050926)2.42120104
163response to laminar fluid shear stress (GO:0034616)2.42098085
164artery morphogenesis (GO:0048844)2.40963859
165retinal ganglion cell axon guidance (GO:0031290)2.39990553
166specification of symmetry (GO:0009799)2.39793166
167microtubule-based movement (GO:0007018)2.39046317
168detection of light stimulus involved in visual perception (GO:0050908)2.36938827
169detection of light stimulus involved in sensory perception (GO:0050962)2.36938827
170ubiquinone metabolic process (GO:0006743)2.36844541
171gamma-aminobutyric acid transport (GO:0015812)2.36757652
172diterpenoid biosynthetic process (GO:0016102)2.35946505
173pyrimidine-containing compound transmembrane transport (GO:0072531)2.35920605
174negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35691127
175regulation of mesoderm development (GO:2000380)2.35044470
176magnesium ion transport (GO:0015693)2.34662060
177indolalkylamine metabolic process (GO:0006586)2.33952252
178renal tubule morphogenesis (GO:0061333)2.32765321
179primary alcohol catabolic process (GO:0034310)2.32064391
180drug catabolic process (GO:0042737)2.31225462
181prostate gland growth (GO:0060736)2.30326966
182eye photoreceptor cell development (GO:0042462)2.30172360
183preassembly of GPI anchor in ER membrane (GO:0016254)2.28644721
184regulation of rhodopsin mediated signaling pathway (GO:0022400)2.28432963
185negative regulation of T cell differentiation in thymus (GO:0033085)2.27333312
186somite development (GO:0061053)2.27112597
187retinal metabolic process (GO:0042574)2.24910648
188retinoic acid metabolic process (GO:0042573)2.23463974
189embryonic epithelial tube formation (GO:0001838)2.22475065
190calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.21694270
191cAMP catabolic process (GO:0006198)2.20914860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.72556985
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.01242382
3GBX2_23144817_ChIP-Seq_PC3_Human3.19555984
4VDR_22108803_ChIP-Seq_LS180_Human3.11008336
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.07785704
6ZNF274_21170338_ChIP-Seq_K562_Hela3.07600232
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76122416
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66233084
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54394817
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.45542313
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44584936
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41703547
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.33091243
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.32340990
15FUS_26573619_Chip-Seq_HEK293_Human2.29768617
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29167196
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.21301527
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.16035722
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.15941380
20AHR_22903824_ChIP-Seq_MCF-7_Human2.03443371
21IGF1R_20145208_ChIP-Seq_DFB_Human1.99089435
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97898773
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97829740
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90839833
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.89598247
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88267771
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85922682
28EWS_26573619_Chip-Seq_HEK293_Human1.82689846
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82623552
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76935378
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.76875526
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.76421212
33CJUN_26792858_Chip-Seq_BT549_Human1.73062469
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.72907315
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71594206
36AR_21572438_ChIP-Seq_LNCaP_Human1.71432185
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68975635
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65217335
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64870345
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64516635
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62836424
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62836424
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.62494539
44SOX2_20726797_ChIP-Seq_SW620_Human1.62098882
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61034020
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60151915
47STAT3_23295773_ChIP-Seq_U87_Human1.58473266
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56560420
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56474292
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55492338
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53336538
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51981883
53CBP_20019798_ChIP-Seq_JUKART_Human1.51981883
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51968424
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51644850
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.51372752
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50362512
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50091854
59ZNF263_19887448_ChIP-Seq_K562_Human1.48783428
60TCF4_22108803_ChIP-Seq_LS180_Human1.48152214
61AR_25329375_ChIP-Seq_VCAP_Human1.47846091
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46180915
63ER_23166858_ChIP-Seq_MCF-7_Human1.46004684
64TCF4_23295773_ChIP-Seq_U87_Human1.44742074
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44051168
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42878023
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42878023
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.42582686
69* EZH2_27294783_Chip-Seq_NPCs_Mouse1.40525505
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40296884
71TP53_18474530_ChIP-ChIP_U2OS_Human1.38788075
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.38027069
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.37758730
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37726028
75CLOCK_20551151_ChIP-Seq_293T_Human1.35069609
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.34696534
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.33881993
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32598622
79NANOG_19829295_ChIP-Seq_ESCs_Human1.29463543
80SOX2_19829295_ChIP-Seq_ESCs_Human1.29463543
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28528758
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27232518
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.26842872
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26729956
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26729956
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26545566
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26068061
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25716770
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24165156
90BCAT_22108803_ChIP-Seq_LS180_Human1.23609500
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23433191
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.22896517
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.22896517
94RXR_22108803_ChIP-Seq_LS180_Human1.22380599
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22141132
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22090994
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22035242
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20621465
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20556488
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20190231
101RUNX2_22187159_ChIP-Seq_PCA_Human1.19922414
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19070760
103P53_22387025_ChIP-Seq_ESCs_Mouse1.17963081
104CDX2_22108803_ChIP-Seq_LS180_Human1.16735945
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16673920
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16649300
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15790293
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.14456698
109RNF2_27304074_Chip-Seq_NSC_Mouse1.14031656
110TP53_22573176_ChIP-Seq_HFKS_Human1.13434321
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13128214
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.10767077
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.10626990
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10262322
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.09820730
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08715064
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08041825
118* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07646196
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06581263
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06531808
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.06531808
122ISL1_27105846_Chip-Seq_CPCs_Mouse1.06357823
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06020689
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03964781
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03870847
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03680894
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.03453920
128* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03138346
129AR_20517297_ChIP-Seq_VCAP_Human1.02864776
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02808664
131EZH2_27304074_Chip-Seq_ESCs_Mouse1.02083329
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.01440474
133TP63_23658742_ChIP-Seq_EP156T_Human1.01390961
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99989117
135TP53_16413492_ChIP-PET_HCT116_Human0.99732356
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.99151419
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98859687
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98462458
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.98415538
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98105822
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97282158
142ETV1_20927104_ChIP-Seq_GIST48_Human0.97116301
143* FLI1_21867929_ChIP-Seq_TH2_Mouse0.97070220
144P300_18555785_Chip-Seq_ESCs_Mouse0.97063012
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95355819
146SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94019394
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90873654
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90213269
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.89178214
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89058381
151* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89040539
152* TAF15_26573619_Chip-Seq_HEK293_Human0.88713267
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88250536
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.86051751
155SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85897327
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85740978
157JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85590825
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.85333016
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.84819712
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84581201
161ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84515878
162GATA3_24758297_ChIP-Seq_MCF-7_Human0.84440131
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84123793
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.84117731
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83693335
166SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83353506
167P300_19829295_ChIP-Seq_ESCs_Human0.82978598
168SMAD4_21799915_ChIP-Seq_A2780_Human0.82553529
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82231477
170JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82142719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001879_abnormal_lymphatic_vessel5.09357015
2MP0005167_abnormal_blood-brain_barrier4.52264657
3MP0004272_abnormal_basement_membrane4.22447165
4MP0006054_spinal_hemorrhage4.11386724
5MP0010368_abnormal_lymphatic_system3.83122177
6MP0005623_abnormal_meninges_morphology3.53754335
7MP0009379_abnormal_foot_pigmentation3.15296679
8MP0001984_abnormal_olfaction3.04955145
9MP0010234_abnormal_vibrissa_follicle2.89341609
10MP0002876_abnormal_thyroid_physiology2.68333052
11MP0002102_abnormal_ear_morphology2.62284555
12MP0008875_abnormal_xenobiotic_pharmacok2.49335016
13MP0009697_abnormal_copulation2.47207785
14MP0003828_pulmonary_edema2.42563274
15MP0000566_synostosis2.36864075
16MP0009780_abnormal_chondrocyte_physiolo2.26838225
17MP0002653_abnormal_ependyma_morphology2.26101293
18MP0000579_abnormal_nail_morphology2.19719718
19MP0002837_dystrophic_cardiac_calcinosis2.12376268
20MP0004043_abnormal_pH_regulation2.10162490
21MP0006072_abnormal_retinal_apoptosis2.08098070
22MP0010678_abnormal_skin_adnexa2.05910085
23MP0005253_abnormal_eye_physiology2.05077499
24MP0005409_darkened_coat_color2.03717152
25MP0002098_abnormal_vibrissa_morphology2.01407756
26MP0003279_aneurysm1.99866220
27MP0004484_altered_response_of1.98602579
28MP0005551_abnormal_eye_electrophysiolog1.96082705
29MP0004147_increased_porphyrin_level1.94904301
30MP0000767_abnormal_smooth_muscle1.92865515
31MP0003724_increased_susceptibility_to1.91281948
32MP0008775_abnormal_heart_ventricle1.89571417
33MP0004885_abnormal_endolymph1.88492913
34MP0004133_heterotaxia1.87923575
35MP0009046_muscle_twitch1.85280137
36MP0000383_abnormal_hair_follicle1.83957257
37MP0000427_abnormal_hair_cycle1.82398136
38MP0002295_abnormal_pulmonary_circulatio1.82359243
39MP0000537_abnormal_urethra_morphology1.80632856
40MP0002127_abnormal_cardiovascular_syste1.79174169
41MP0003136_yellow_coat_color1.68168404
42MP0005645_abnormal_hypothalamus_physiol1.66416448
43MP0002796_impaired_skin_barrier1.64709398
44MP0005165_increased_susceptibility_to1.59516863
45MP0006138_congestive_heart_failure1.59256124
46MP0003941_abnormal_skin_development1.57501376
47MP0002638_abnormal_pupillary_reflex1.57493867
48MP0001501_abnormal_sleep_pattern1.56273303
49MP0002254_reproductive_system_inflammat1.55343636
50MP0004084_abnormal_cardiac_muscle1.54709668
51MP0005187_abnormal_penis_morphology1.52718423
52MP0004883_abnormal_blood_vessel1.51525692
53MP0000013_abnormal_adipose_tissue1.50979803
54MP0003195_calcinosis1.50306667
55MP0010630_abnormal_cardiac_muscle1.49090671
56MP0003567_abnormal_fetal_cardiomyocyte1.48294856
57MP0006276_abnormal_autonomic_nervous1.47621247
58MP0005385_cardiovascular_system_phenoty1.46987348
59MP0001544_abnormal_cardiovascular_syste1.46987348
60MP0005646_abnormal_pituitary_gland1.42404802
61MP0005503_abnormal_tendon_morphology1.37914924
62MP0001346_abnormal_lacrimal_gland1.37782718
63MP0009384_cardiac_valve_regurgitation1.36013126
64MP0003646_muscle_fatigue1.35321398
65MP0005084_abnormal_gallbladder_morpholo1.33554126
66MP0002277_abnormal_respiratory_mucosa1.32913739
67MP0001485_abnormal_pinna_reflex1.31547807
68MP0008872_abnormal_physiological_respon1.31440148
69MP0005171_absent_coat_pigmentation1.30974986
70MP0010386_abnormal_urinary_bladder1.29953014
71MP0000249_abnormal_blood_vessel1.26855341
72MP0002009_preneoplasia1.25830633
73MP0000631_abnormal_neuroendocrine_gland1.25235135
74MP0001851_eye_inflammation1.25053957
75MP0001915_intracranial_hemorrhage1.24359684
76MP0002925_abnormal_cardiovascular_devel1.24338463
77MP0002138_abnormal_hepatobiliary_system1.21612435
78MP0002332_abnormal_exercise_endurance1.21453127
79MP0002972_abnormal_cardiac_muscle1.19608285
80MP0000762_abnormal_tongue_morphology1.19305564
81MP0004215_abnormal_myocardial_fiber1.17888803
82MP0003943_abnormal_hepatobiliary_system1.17620673
83MP0003937_abnormal_limbs/digits/tail_de1.16457808
84MP0001502_abnormal_circadian_rhythm1.15761876
85MP0001986_abnormal_taste_sensitivity1.15164167
86MP0005595_abnormal_vascular_smooth1.14709789
87MP0003566_abnormal_cell_adhesion1.14065598
88MP0002928_abnormal_bile_duct1.13894033
89MP0003011_delayed_dark_adaptation1.13844128
90MP0000049_abnormal_middle_ear1.13703142
91MP0002128_abnormal_blood_circulation1.13179471
92MP0002938_white_spotting1.10673027
93MP0005367_renal/urinary_system_phenotyp1.09871986
94MP0000516_abnormal_urinary_system1.09871986
95MP0008995_early_reproductive_senescence1.08353621
96MP0005195_abnormal_posterior_eye1.08043045
97MP0002736_abnormal_nociception_after1.07370864
98MP0000026_abnormal_inner_ear1.06231776
99MP0004142_abnormal_muscle_tone1.04994790
100MP0002282_abnormal_trachea_morphology1.04548710
101MP0000343_altered_response_to1.04493897
102MP0004085_abnormal_heartbeat1.03832274
103MP0001968_abnormal_touch/_nociception1.03829253
104MP0000613_abnormal_salivary_gland1.03583459
105MP0002272_abnormal_nervous_system1.02866598
106MP0009745_abnormal_behavioral_response1.02274655
107MP0003950_abnormal_plasma_membrane1.02247009
108MP0000372_irregular_coat_pigmentation1.02135543
109MP0005164_abnormal_response_to1.01805452
110MP0002234_abnormal_pharynx_morphology1.01018859
111MP0005388_respiratory_system_phenotype1.00788135
112MP0002133_abnormal_respiratory_system1.00788135
113MP0004782_abnormal_surfactant_physiolog1.00278229
114MP0009053_abnormal_anal_canal0.99702699
115MP0003786_premature_aging0.99337119
116MP0003252_abnormal_bile_duct0.98833292
117MP0005330_cardiomyopathy0.98642440
118MP0005394_taste/olfaction_phenotype0.98528262
119MP0005499_abnormal_olfactory_system0.98528262
120MP0000647_abnormal_sebaceous_gland0.98279822
121MP0005389_reproductive_system_phenotype0.96588473
122MP0001849_ear_inflammation0.96425202
123MP0004036_abnormal_muscle_relaxation0.96019648
124MP0001614_abnormal_blood_vessel0.95537885
125MP0008789_abnormal_olfactory_epithelium0.95165757
126MP0001486_abnormal_startle_reflex0.94549885
127MP0002060_abnormal_skin_morphology0.94153707
128MP0002160_abnormal_reproductive_system0.93705386
129MP0008004_abnormal_stomach_pH0.93421446
130MP0005408_hypopigmentation0.92808657
131MP0005620_abnormal_muscle_contractility0.90883513
132MP0003755_abnormal_palate_morphology0.90812948
133MP0004145_abnormal_muscle_electrophysio0.90608889
134MP0000230_abnormal_systemic_arterial0.90467600
135MP0000467_abnormal_esophagus_morphology0.89409962
136MP0003878_abnormal_ear_physiology0.88946017
137MP0005377_hearing/vestibular/ear_phenot0.88946017
138MP0002249_abnormal_larynx_morphology0.88873334
139MP0001958_emphysema0.87633423
140MP0003137_abnormal_impulse_conducting0.86063822
141MP0008877_abnormal_DNA_methylation0.85539700
142MP0005391_vision/eye_phenotype0.84302782
143MP0002108_abnormal_muscle_morphology0.84208072
144MP0004019_abnormal_vitamin_homeostasis0.83832110
145MP0009278_abnormal_bone_marrow0.82604059
146MP0002233_abnormal_nose_morphology0.81517975
147MP0000266_abnormal_heart_morphology0.81024938
148MP0000569_abnormal_digit_pigmentation0.80528915
149MP0001784_abnormal_fluid_regulation0.79301677
150MP0003880_abnormal_central_pattern0.78696175
151MP0003453_abnormal_keratinocyte_physiol0.78294335
152MP0003718_maternal_effect0.77569282
153MP0002752_abnormal_somatic_nervous0.77453435
154MP0000377_abnormal_hair_follicle0.75478720
155MP0003935_abnormal_craniofacial_develop0.73754401
156MP0002168_other_aberrant_phenotype0.73250207
157MP0003638_abnormal_response/metabolism_0.73012488
158MP0004924_abnormal_behavior0.72647470
159MP0005386_behavior/neurological_phenoty0.72647470
160MP0005248_abnormal_Harderian_gland0.71946559
161MP0005275_abnormal_skin_tensile0.71721139
162MP0002572_abnormal_emotion/affect_behav0.71651619
163MP0005501_abnormal_skin_physiology0.70400702
164MP0010771_integument_phenotype0.68784268
165MP0001216_abnormal_epidermal_layer0.67641875
166MP0003705_abnormal_hypodermis_morpholog0.67477077
167MP0003300_gastrointestinal_ulcer0.65820825
168MP0002896_abnormal_bone_mineralization0.65198856

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.10421805
2Onycholysis (HP:0001806)4.65459243
3Right ventricular cardiomyopathy (HP:0011663)4.25758989
4Abnormal respiratory motile cilium physiology (HP:0012261)4.17208544
5Chronic bronchitis (HP:0004469)4.10442332
6Pancreatic fibrosis (HP:0100732)3.96358844
7Absent hand (HP:0004050)3.95624937
8Nephronophthisis (HP:0000090)3.95024069
9True hermaphroditism (HP:0010459)3.90844147
10Pancreatic cysts (HP:0001737)3.90210316
11Esophageal varix (HP:0002040)3.89140054
12Molar tooth sign on MRI (HP:0002419)3.87277194
13Abnormality of midbrain morphology (HP:0002418)3.87277194
14Milia (HP:0001056)3.64798166
15Abnormality of the renal medulla (HP:0100957)3.61172710
16Chronic hepatic failure (HP:0100626)3.52404816
17Absent/shortened dynein arms (HP:0200106)3.49703469
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.49703469
19Congenital, generalized hypertrichosis (HP:0004540)3.47902291
20Distal lower limb muscle weakness (HP:0009053)3.29964869
21Mesangial abnormality (HP:0001966)3.25801668
22Exercise-induced muscle cramps (HP:0003710)3.24622455
23Absent eyebrow (HP:0002223)3.22821813
24Abnormality of the renal cortex (HP:0011035)3.21379805
25Abnormal ciliary motility (HP:0012262)3.20119900
26Vertebral arch anomaly (HP:0008438)3.19893972
27Rhinitis (HP:0012384)3.15886576
28Adactyly (HP:0009776)3.15342125
29Aplasia cutis congenita (HP:0001057)3.11731489
30Ventricular tachycardia (HP:0004756)3.11189461
31Medial flaring of the eyebrow (HP:0010747)3.05419097
32Lymphangioma (HP:0100764)3.03151649
33Portal hypertension (HP:0001409)3.02339833
34Hypotrichosis (HP:0001006)3.02190251
35Occipital encephalocele (HP:0002085)2.97525146
36Absent eyelashes (HP:0000561)2.94302920
37Polydipsia (HP:0001959)2.89550400
38Abnormal drinking behavior (HP:0030082)2.89550400
39Thick nail (HP:0001805)2.86538448
40Abnormality of the axillary hair (HP:0100134)2.85162723
41Abnormality of secondary sexual hair (HP:0009888)2.85162723
42J-shaped sella turcica (HP:0002680)2.81625080
43Abnormality of the nasal mucosa (HP:0000433)2.80204355
44Pulmonary artery stenosis (HP:0004415)2.79332164
45Type II lissencephaly (HP:0007260)2.79073743
46Woolly hair (HP:0002224)2.77063931
47Cystic liver disease (HP:0006706)2.73253695
48Facial shape deformation (HP:0011334)2.69333333
49Potter facies (HP:0002009)2.69333333
50Nasal polyposis (HP:0100582)2.67475296
51Abnormality of the hepatic vasculature (HP:0006707)2.67155680
52Fragile nails (HP:0001808)2.63440298
53Hyporeflexia of lower limbs (HP:0002600)2.59734853
54Tubulointerstitial nephritis (HP:0001970)2.57465692
55Stenosis of the external auditory canal (HP:0000402)2.54804308
56Hypoglycemic coma (HP:0001325)2.54362384
57Stomach cancer (HP:0012126)2.52741133
58Polycythemia (HP:0001901)2.51271325
59Vascular tortuosity (HP:0004948)2.44735651
60Abnormal respiratory epithelium morphology (HP:0012253)2.44611511
61Abnormal respiratory motile cilium morphology (HP:0005938)2.44611511
62Hypoplastic labia majora (HP:0000059)2.44270877
63Postaxial foot polydactyly (HP:0001830)2.42390815
64Hematochezia (HP:0002573)2.41612536
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.39345532
66Increased connective tissue (HP:0009025)2.37626355
67Alopecia of scalp (HP:0002293)2.35235680
68Thyroid-stimulating hormone excess (HP:0002925)2.34495718
69Gait imbalance (HP:0002141)2.34437262
70Congenital primary aphakia (HP:0007707)2.34148875
71Atrophic scars (HP:0001075)2.33015532
72Furrowed tongue (HP:0000221)2.31711453
73Plantar hyperkeratosis (HP:0007556)2.31563246
74Pancreatic islet-cell hyperplasia (HP:0004510)2.30430792
75Muscle fiber splitting (HP:0003555)2.29776816
76Arterial tortuosity (HP:0005116)2.28970900
77Abnormality of the fetal cardiovascular system (HP:0010948)2.23572656
78Abnormal umbilical cord blood vessels (HP:0011403)2.23572656
79Single umbilical artery (HP:0001195)2.23572656
80Abnormality of the labia majora (HP:0012881)2.23065846
81Abnormal hemoglobin (HP:0011902)2.20731667
82Sudden death (HP:0001699)2.20394185
83Hypoplastic scapulae (HP:0000882)2.19441077
84Aplasia/Hypoplasia of the scapulae (HP:0006713)2.19441077
85Polyuria (HP:0000103)2.18933642
86Atrial fibrillation (HP:0005110)2.18335115
87Abnormality of the nasal septum (HP:0000419)2.16364569
88Genital tract atresia (HP:0001827)2.14314853
89Renal cortical cysts (HP:0000803)2.11844265
90Hyperactive renin-angiotensin system (HP:0000841)2.11446187
91Congenital stationary night blindness (HP:0007642)2.10221503
92Nail dystrophy (HP:0008404)2.09857931
93Decreased circulating renin level (HP:0003351)2.07443426
94Vaginal atresia (HP:0000148)2.05145122
95Popliteal pterygium (HP:0009756)2.04909702
96Supraventricular arrhythmia (HP:0005115)2.03985069
97Nephrogenic diabetes insipidus (HP:0009806)2.03354914
98Bronchitis (HP:0012387)2.03299704
99Cerebellar dysplasia (HP:0007033)2.02985954
100Primary atrial arrhythmia (HP:0001692)2.02870600
101Tubulointerstitial abnormality (HP:0001969)2.02764513
102Duplicated collecting system (HP:0000081)2.02722195
103Porencephaly (HP:0002132)2.02368030
104Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.01929491
105Sclerocornea (HP:0000647)2.01806444
106Labial hypoplasia (HP:0000066)2.01383935
107Postaxial hand polydactyly (HP:0001162)2.00350981
108Abnormal rod and cone electroretinograms (HP:0008323)2.00068030
109Increased corneal curvature (HP:0100692)1.99520544
110Keratoconus (HP:0000563)1.99520544
111Hyperinsulinemic hypoglycemia (HP:0000825)1.99375113
112Hypoplasia of the iris (HP:0007676)1.98436130
113Acanthosis nigricans (HP:0000956)1.97672057
114Abnormality of the renal collecting system (HP:0004742)1.96667460
115Decreased central vision (HP:0007663)1.96509462
116Tubular atrophy (HP:0000092)1.95577933
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.95405689
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94265418
119Bronchomalacia (HP:0002780)1.92673065
120Pili torti (HP:0003777)1.89977921
121Aplasia/Hypoplasia of the spleen (HP:0010451)1.89696123
122Colitis (HP:0002583)1.89557917
123Absent hair (HP:0002298)1.89509433
124Facial diplegia (HP:0001349)1.89192119
125Recurrent sinusitis (HP:0011108)1.89079268
126Supraventricular tachycardia (HP:0004755)1.89037294
127Hypoglycemic seizures (HP:0002173)1.88089177
128Abnormal biliary tract physiology (HP:0012439)1.86720560
129Bile duct proliferation (HP:0001408)1.86720560
130Hydroureter (HP:0000072)1.86493530
131Neonatal death (HP:0003811)1.86139077
132Esophageal atresia (HP:0002032)1.86020838
133Male pseudohermaphroditism (HP:0000037)1.85541184
134Autoimmune hemolytic anemia (HP:0001890)1.84954822
135Flat acetabular roof (HP:0003180)1.84442420
136Asplenia (HP:0001746)1.83864561
137Anencephaly (HP:0002323)1.82871201
138Congenital hepatic fibrosis (HP:0002612)1.81902473
139Subacute progressive viral hepatitis (HP:0006572)1.81606146
140Micronodular cirrhosis (HP:0001413)1.81154832
141Calf muscle hypertrophy (HP:0008981)1.79733446
142Short tibia (HP:0005736)1.78063037
143Aplasia/hypoplasia of the uterus (HP:0008684)1.77935793
144Hypokalemic alkalosis (HP:0001949)1.77411195
145Abnormality of macular pigmentation (HP:0008002)1.77185279
146Abolished electroretinogram (ERG) (HP:0000550)1.76061425
147Ridged nail (HP:0001807)1.75983499
148Difficulty running (HP:0009046)1.75560190
149Abnormality of the calf musculature (HP:0001430)1.75101967
150Skull defect (HP:0001362)1.74580279
151Hyperventilation (HP:0002883)1.74394909
152Abnormality of the labia minora (HP:0012880)1.74053089
153Corneal dystrophy (HP:0001131)1.74034374
154Abnormal urine output (HP:0012590)1.72874221
155Bronchiectasis (HP:0002110)1.72289756
156Gastrointestinal atresia (HP:0002589)1.71459925
157Hypoplasia of the uterus (HP:0000013)1.71396724
158Lipoatrophy (HP:0100578)1.71161951
159Hyperkalemia (HP:0002153)1.70336130
160Hypoplasia of dental enamel (HP:0006297)1.69222350
161Germ cell neoplasia (HP:0100728)1.69069481
162Periauricular skin pits (HP:0100277)1.68843931
163Preauricular pit (HP:0004467)1.68843931
164Down-sloping shoulders (HP:0200021)1.68771878
165Testicular atrophy (HP:0000029)1.68365019
166Attenuation of retinal blood vessels (HP:0007843)1.67622589
167Abnormality of renal excretion (HP:0011036)1.67208372
168Chronic sinusitis (HP:0011109)1.66961875
169Hypoplastic female external genitalia (HP:0012815)1.66590031
170Methylmalonic acidemia (HP:0002912)1.66192558
171Tubulointerstitial fibrosis (HP:0005576)1.65942400
172Hemiparesis (HP:0001269)1.63650370
173Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63433715
174Abnormality of renin-angiotensin system (HP:0000847)1.63117165
175Fair hair (HP:0002286)1.61797428
176Hypomagnesemia (HP:0002917)1.60791340
177Conical tooth (HP:0000698)1.60692114
178Lipid accumulation in hepatocytes (HP:0006561)1.60482658
179Cone-rod dystrophy (HP:0000548)1.58899104
180Hyperaldosteronism (HP:0000859)1.58583843
181Split foot (HP:0001839)1.56671735
182Preaxial hand polydactyly (HP:0001177)1.56362770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.22985538
2KDR5.53338557
3PDK23.55171086
4TAOK33.43894803
5EPHB23.17537285
6TGFBR22.98667793
7MAPK152.91272165
8WNK32.90550302
9MAP4K22.90375879
10GRK12.74455448
11MST42.50908051
12EPHA22.43348674
13MAP3K32.34471814
14INSRR2.27009497
15ADRBK22.14941769
16TLK12.13841402
17PTK2B2.11175109
18FER2.05262454
19AKT32.01574325
20TGFBR11.98608509
21PINK11.94608499
22MAP3K41.77442352
23TXK1.72140788
24PTK61.60774028
25OXSR11.57825154
26MAP3K21.57382443
27CASK1.51371344
28MYLK1.50475928
29BCKDK1.48386306
30STK38L1.40166232
31MAPK131.39499759
32FRK1.35931987
33LATS11.34921227
34MAP2K21.21613947
35BRSK21.19870677
36TRIM281.19008372
37DMPK1.18238274
38PDK41.15451950
39PDK31.15451950
40MAP2K71.12802428
41BMPR1B1.11774513
42TTN1.11223908
43TEC1.08977173
44ITK1.08706834
45PRKG21.06697809
46MARK11.04839950
47MET1.04540368
48LRRK21.03513374
49PRPF4B1.01816032
50FGFR21.01812861
51BCR1.01128391
52ERBB31.00495878
53MAPK70.98809976
54MAPKAPK30.98563832
55EPHA30.98368724
56NUAK10.94252634
57PRKD10.93379568
58LMTK20.85083295
59ERBB20.82257815
60MAP2K30.82007887
61RPS6KB20.81207667
62PAK40.80472407
63NEK10.80149208
64ADRBK10.79433519
65STK390.79178671
66WNK40.78527757
67PRKCE0.78240771
68TRPM70.77905557
69MAPK120.76805566
70PTK20.74678344
71TNIK0.73789369
72PNCK0.73728018
73IGF1R0.72271005
74MKNK20.71675034
75MAP2K10.71361006
76ACVR1B0.70855858
77STK100.70511111
78GSK3A0.68163706
79STK160.67915424
80PLK20.67135403
81NEK60.66687055
82PRKCG0.61938870
83PASK0.61535188
84CSNK1A1L0.60353261
85IKBKB0.59510013
86PHKG20.58426804
87PHKG10.58426804
88EIF2AK30.58134984
89CAMK2A0.57595991
90MKNK10.57268351
91IRAK10.56218728
92WNK10.55384094
93PRKCQ0.54673361
94MAP3K120.53747979
95ZAK0.53093705
96MAP3K60.52502879
97PAK30.50460223
98ERN10.49408979
99CAMK2D0.48844583
100MAP3K70.48447265
101CDK60.48284133
102PRKAA20.47978021
103GRK70.47935896
104STK240.47734043
105TAOK20.47516874
106TSSK60.47495855
107DDR20.46983982
108PRKACA0.46921123
109INSR0.44699787
110OBSCN0.43728696
111PAK20.42667639
112PLK30.41652954
113LIMK10.41442070
114PIK3CA0.41363474
115ROCK10.40472365
116RPS6KA50.40396492
117CSNK1A10.39805253
118SIK10.39464580
119VRK10.39352245
120MUSK0.39254734
121FGFR10.39021855
122PRKCI0.38990861
123ABL10.38904748
124CSNK1G10.38522751
125MAP3K140.37744314
126SRC0.37667615
127EPHB10.37403681
128CAMKK20.37355941
129DYRK20.36803736
130MAPKAPK20.36757297
131DYRK1B0.36641341
132PRKCA0.36460607
133STK30.36272484
134CDK30.35950500
135EPHA40.35683643
136MAPKAPK50.34098840
137DAPK20.33512645
138MST1R0.32196438
139PKN10.32111395
140NLK0.31958555
141AKT20.31791916
142TESK10.29823289
143FGFR30.29700306
144RIPK10.28621502
145CSNK1G20.27606125
146CAMK10.25329641
147MARK30.25291167
148GRK50.23056422
149CHUK0.22492569
150EGFR0.22383015
151ROCK20.20758143
152CSNK1G30.20347270
153DYRK30.20221704

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.04057355
2Adherens junction_Homo sapiens_hsa045203.01725249
3Nitrogen metabolism_Homo sapiens_hsa009102.66893068
4Leukocyte transendothelial migration_Homo sapiens_hsa046702.51344769
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.44453146
6Phototransduction_Homo sapiens_hsa047442.42458216
7ECM-receptor interaction_Homo sapiens_hsa045122.41530875
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26992358
9Tight junction_Homo sapiens_hsa045302.25457673
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18855015
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17257948
12Chemical carcinogenesis_Homo sapiens_hsa052042.16840290
13Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.16054875
14Focal adhesion_Homo sapiens_hsa045102.10475920
15Oxidative phosphorylation_Homo sapiens_hsa001901.96783923
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95528833
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90728576
18Circadian rhythm_Homo sapiens_hsa047101.88000175
19Butanoate metabolism_Homo sapiens_hsa006501.82776386
20Protein export_Homo sapiens_hsa030601.79618161
21Basal cell carcinoma_Homo sapiens_hsa052171.76958313
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71285778
23Dilated cardiomyopathy_Homo sapiens_hsa054141.70673187
24Selenocompound metabolism_Homo sapiens_hsa004501.69495728
25Hippo signaling pathway_Homo sapiens_hsa043901.67924433
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67451940
27Axon guidance_Homo sapiens_hsa043601.58873140
28Huntingtons disease_Homo sapiens_hsa050161.58421983
29Rap1 signaling pathway_Homo sapiens_hsa040151.57310429
30Nicotine addiction_Homo sapiens_hsa050331.55463929
31ABC transporters_Homo sapiens_hsa020101.54372100
32Peroxisome_Homo sapiens_hsa041461.54099757
33Tryptophan metabolism_Homo sapiens_hsa003801.52025472
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48772879
35Mineral absorption_Homo sapiens_hsa049781.47514721
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46761851
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.39098849
38TGF-beta signaling pathway_Homo sapiens_hsa043501.38646909
39Basal transcription factors_Homo sapiens_hsa030221.37104849
40Ether lipid metabolism_Homo sapiens_hsa005651.36408102
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35924712
42Parkinsons disease_Homo sapiens_hsa050121.33760405
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33715040
44Proteoglycans in cancer_Homo sapiens_hsa052051.33166858
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.30286995
46Melanogenesis_Homo sapiens_hsa049161.25544021
47Retinol metabolism_Homo sapiens_hsa008301.25205386
48Caffeine metabolism_Homo sapiens_hsa002321.24968340
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19738066
50Sphingolipid metabolism_Homo sapiens_hsa006001.18390166
51Taste transduction_Homo sapiens_hsa047421.16712995
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.15771556
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15079324
54Olfactory transduction_Homo sapiens_hsa047401.14240974
55Ovarian steroidogenesis_Homo sapiens_hsa049131.12805187
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12385782
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11999086
58Regulation of autophagy_Homo sapiens_hsa041401.09826512
59Wnt signaling pathway_Homo sapiens_hsa043101.08784943
60Fatty acid degradation_Homo sapiens_hsa000711.08397534
61Fanconi anemia pathway_Homo sapiens_hsa034601.06267730
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04051153
63Sulfur metabolism_Homo sapiens_hsa009201.03978160
64Amoebiasis_Homo sapiens_hsa051461.02311241
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01355333
66Pathways in cancer_Homo sapiens_hsa052000.98738085
67Salivary secretion_Homo sapiens_hsa049700.96334050
68RNA degradation_Homo sapiens_hsa030180.95865577
69Alzheimers disease_Homo sapiens_hsa050100.94708589
70Ras signaling pathway_Homo sapiens_hsa040140.94537116
71Protein digestion and absorption_Homo sapiens_hsa049740.94408765
72Glutathione metabolism_Homo sapiens_hsa004800.93231172
73Notch signaling pathway_Homo sapiens_hsa043300.93064823
74Morphine addiction_Homo sapiens_hsa050320.93012113
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92516768
76Small cell lung cancer_Homo sapiens_hsa052220.92352020
77Prostate cancer_Homo sapiens_hsa052150.92326792
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92142693
79Platelet activation_Homo sapiens_hsa046110.92006719
80GABAergic synapse_Homo sapiens_hsa047270.91343606
81Dorso-ventral axis formation_Homo sapiens_hsa043200.90962406
82Thyroid cancer_Homo sapiens_hsa052160.90857714
83Hedgehog signaling pathway_Homo sapiens_hsa043400.90595480
84Fatty acid elongation_Homo sapiens_hsa000620.89989700
85Phenylalanine metabolism_Homo sapiens_hsa003600.89876917
86Cardiac muscle contraction_Homo sapiens_hsa042600.87526889
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86864897
88Viral myocarditis_Homo sapiens_hsa054160.85439940
89HIF-1 signaling pathway_Homo sapiens_hsa040660.83882773
90Circadian entrainment_Homo sapiens_hsa047130.82352566
91Gastric acid secretion_Homo sapiens_hsa049710.81481033
92Steroid biosynthesis_Homo sapiens_hsa001000.81019821
93PPAR signaling pathway_Homo sapiens_hsa033200.80548974
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79180138
95beta-Alanine metabolism_Homo sapiens_hsa004100.78547095
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75979860
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75571370
98Bile secretion_Homo sapiens_hsa049760.75353274
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73734783
100MicroRNAs in cancer_Homo sapiens_hsa052060.72597967
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72028581
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70849546
103Arachidonic acid metabolism_Homo sapiens_hsa005900.70671203
104VEGF signaling pathway_Homo sapiens_hsa043700.70563535
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.70322018
106Fatty acid metabolism_Homo sapiens_hsa012120.70313268
107Gap junction_Homo sapiens_hsa045400.70045600
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69831121
109Estrogen signaling pathway_Homo sapiens_hsa049150.69125104
110Collecting duct acid secretion_Homo sapiens_hsa049660.69122201
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68647227
112Serotonergic synapse_Homo sapiens_hsa047260.67291854
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65220345
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64992784
115Propanoate metabolism_Homo sapiens_hsa006400.64798996
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64720972
117RNA polymerase_Homo sapiens_hsa030200.64705601
118Insulin secretion_Homo sapiens_hsa049110.64079584
119Vitamin digestion and absorption_Homo sapiens_hsa049770.63773872
120Pancreatic secretion_Homo sapiens_hsa049720.62381794
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62304300
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61267734
123Histidine metabolism_Homo sapiens_hsa003400.61019818
124Renin secretion_Homo sapiens_hsa049240.60997702
125TNF signaling pathway_Homo sapiens_hsa046680.60587946
126Hepatitis C_Homo sapiens_hsa051600.60155934
127Metabolic pathways_Homo sapiens_hsa011000.59906976
128Linoleic acid metabolism_Homo sapiens_hsa005910.59189177
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58425715
130Insulin resistance_Homo sapiens_hsa049310.57721544
131Fatty acid biosynthesis_Homo sapiens_hsa000610.57181506
132Starch and sucrose metabolism_Homo sapiens_hsa005000.56772611
133Tyrosine metabolism_Homo sapiens_hsa003500.56441664
134Melanoma_Homo sapiens_hsa052180.54952130
135Purine metabolism_Homo sapiens_hsa002300.54508039
136Oxytocin signaling pathway_Homo sapiens_hsa049210.53583127
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53157379
138Malaria_Homo sapiens_hsa051440.53076845
139Glutamatergic synapse_Homo sapiens_hsa047240.52394482
140Renal cell carcinoma_Homo sapiens_hsa052110.52348160
141Toxoplasmosis_Homo sapiens_hsa051450.51956747
142Asthma_Homo sapiens_hsa053100.50969375
143Hematopoietic cell lineage_Homo sapiens_hsa046400.50795222
144Fat digestion and absorption_Homo sapiens_hsa049750.50003587
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49729278
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49327285
147Type I diabetes mellitus_Homo sapiens_hsa049400.48550720
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48166492
149African trypanosomiasis_Homo sapiens_hsa051430.47248660
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47202617
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.46240100
152Thyroid hormone synthesis_Homo sapiens_hsa049180.45664533
153Calcium signaling pathway_Homo sapiens_hsa040200.44767599
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.43742591
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41808252
156Arginine and proline metabolism_Homo sapiens_hsa003300.36923785
157cAMP signaling pathway_Homo sapiens_hsa040240.33745833
158Glycerolipid metabolism_Homo sapiens_hsa005610.33334342

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