RAVER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drinking behavior (GO:0042756)9.66322840
2positive regulation of vascular permeability (GO:0043117)9.52832251
3negative regulation of digestive system process (GO:0060457)8.13070053
4negative regulation of cell size (GO:0045792)7.65256951
5negative regulation of necrotic cell death (GO:0060547)6.78580763
6hormone catabolic process (GO:0042447)6.75844847
7negative regulation of response to food (GO:0032096)6.69347843
8negative regulation of appetite (GO:0032099)6.69347843
9mannose metabolic process (GO:0006013)6.30406520
10carnitine transmembrane transport (GO:1902603)6.00375042
11regulation of appetite (GO:0032098)5.65527123
12amino-acid betaine transport (GO:0015838)5.64969376
13carnitine transport (GO:0015879)5.64969376
14peptide catabolic process (GO:0043171)5.62227054
15carnitine shuttle (GO:0006853)5.48209478
16determination of adult lifespan (GO:0008340)4.96370380
17regulation of feeding behavior (GO:0060259)4.92449060
18positive regulation of actin filament depolymerization (GO:0030836)4.86004224
19regulation of response to food (GO:0032095)4.79594756
20aerobic respiration (GO:0009060)4.59073369
21activation of protein kinase A activity (GO:0034199)4.56156812
22regulation of glucocorticoid secretion (GO:2000849)4.55223434
23trivalent inorganic anion homeostasis (GO:0072506)4.51156933
24phosphate ion homeostasis (GO:0055062)4.51156933
25snRNA transcription (GO:0009301)4.45628119
26mitotic sister chromatid cohesion (GO:0007064)4.31495770
27fatty acid transmembrane transport (GO:1902001)4.29935834
28cellular response to ATP (GO:0071318)4.24460929
29locomotory exploration behavior (GO:0035641)4.20399436
30head development (GO:0060322)4.19157349
31viral mRNA export from host cell nucleus (GO:0046784)4.13317049
32N-glycan processing (GO:0006491)4.12369596
33vocalization behavior (GO:0071625)4.12077843
34grooming behavior (GO:0007625)4.08147340
35positive regulation of calcium ion import (GO:0090280)4.06313487
36quaternary ammonium group transport (GO:0015697)4.05397054
37aldehyde catabolic process (GO:0046185)4.00578913
38regulation of necrotic cell death (GO:0010939)3.97031134
39DNA replication checkpoint (GO:0000076)3.95563458
40spermatid nucleus differentiation (GO:0007289)3.94869915
41beta-amyloid metabolic process (GO:0050435)3.90765162
42axonal fasciculation (GO:0007413)3.75419824
43regulation of corticosteroid hormone secretion (GO:2000846)3.73365992
44glutamate receptor signaling pathway (GO:0007215)3.61369175
45positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.57883052
46cochlea development (GO:0090102)3.55182930
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55102675
48cellular anion homeostasis (GO:0030002)3.55005970
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54102430
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53928610
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.53614034
52cellular sodium ion homeostasis (GO:0006883)3.51134711
53positive regulation of heart contraction (GO:0045823)3.51069523
54regulation of endocrine process (GO:0044060)3.50961630
55DNA ligation (GO:0006266)3.48619292
56innervation (GO:0060384)3.45380803
57negative regulation of cell cycle G2/M phase transition (GO:1902750)3.43122502
58exploration behavior (GO:0035640)3.40141427
59neuron recognition (GO:0008038)3.37667146
60regulation of glutamate receptor signaling pathway (GO:1900449)3.36050429
61negative regulation of response to nutrient levels (GO:0032108)3.35991279
62negative regulation of response to extracellular stimulus (GO:0032105)3.35991279
63regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.34944516
64regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33602994
65glial cell proliferation (GO:0014009)3.33369273
66DNA topological change (GO:0006265)3.30440108
67synaptic vesicle docking involved in exocytosis (GO:0016081)3.30409012
68positive regulation of collagen biosynthetic process (GO:0032967)3.30375751
69regulation of somitogenesis (GO:0014807)3.28786444
70regulation of calcium ion import (GO:0090279)3.27532928
71negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.26672711
72glomerulus development (GO:0032835)3.26642718
73synaptic vesicle exocytosis (GO:0016079)3.25849532
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.25705300
75Notch signaling involved in heart development (GO:0061314)3.22976293
76glomerular visceral epithelial cell development (GO:0072015)3.18109464
77protein localization to synapse (GO:0035418)3.17758646
78synaptic vesicle maturation (GO:0016188)3.17670886
79dendritic spine morphogenesis (GO:0060997)3.17378854
80cellular potassium ion homeostasis (GO:0030007)3.17306092
81positive regulation of megakaryocyte differentiation (GO:0045654)3.16382550
82positive regulation of vasodilation (GO:0045909)3.16023296
83layer formation in cerebral cortex (GO:0021819)3.15835890
84regulation of protein deacetylation (GO:0090311)3.15514960
85dendritic spine organization (GO:0097061)3.14625167
86aorta morphogenesis (GO:0035909)3.14141600
87sodium ion export (GO:0071436)3.13184171
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11381805
89regulation of synapse structural plasticity (GO:0051823)3.11185853
90positive regulation of collagen metabolic process (GO:0010714)3.11166730
91endocardial cushion morphogenesis (GO:0003203)3.10887263
92epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.10339706
93regulation of neuronal synaptic plasticity (GO:0048168)3.08582810
94mesenchyme morphogenesis (GO:0072132)3.05443214
95positive regulation of synapse maturation (GO:0090129)3.05401503
96cell communication by electrical coupling (GO:0010644)3.05330175
97synaptic transmission, glutamatergic (GO:0035249)3.03403395
98regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.02270324
99glomerular epithelial cell development (GO:0072310)3.01681605
100glutamate secretion (GO:0014047)3.00681411
101auditory behavior (GO:0031223)3.00534174
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99850057
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99311018
104regulation of dendritic spine morphogenesis (GO:0061001)2.98704246
105outer ear morphogenesis (GO:0042473)2.98540881
106lymphoid progenitor cell differentiation (GO:0002320)2.98423073
107tricarboxylic acid cycle (GO:0006099)2.98048305
108establishment of nucleus localization (GO:0040023)2.97914510
109protein prenylation (GO:0018342)2.97884285
110prenylation (GO:0097354)2.97884285
111negative regulation of histone modification (GO:0031057)2.97456140
112regulation of digestive system process (GO:0044058)2.97446845
113photoreceptor cell maintenance (GO:0045494)2.96594464
114paraxial mesoderm development (GO:0048339)2.95312889
115I-kappaB phosphorylation (GO:0007252)2.93631852
116ribosomal small subunit assembly (GO:0000028)2.92319177
117neuron cell-cell adhesion (GO:0007158)2.91792130
118glomerular basement membrane development (GO:0032836)2.91419910
119regulation of steroid hormone secretion (GO:2000831)2.90407200
120mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.90183929
121cellular respiration (GO:0045333)2.89250898
122modified amino acid transport (GO:0072337)2.86283797
123ribosome assembly (GO:0042255)2.86149992
124negative regulation of chromatin modification (GO:1903309)2.81666807
125histone H2A monoubiquitination (GO:0035518)2.81641936
126inner ear receptor cell development (GO:0060119)2.80626070
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.79857283
128synaptic vesicle endocytosis (GO:0048488)2.79245394
129L-amino acid import (GO:0043092)2.78053630
130regulation of histone deacetylation (GO:0031063)2.77679889
131negative regulation of sodium ion transport (GO:0010766)2.77444583
132sister chromatid cohesion (GO:0007062)2.77002247
133ribosomal large subunit biogenesis (GO:0042273)2.76657102
134lateral sprouting from an epithelium (GO:0060601)2.74993543
135ncRNA 3-end processing (GO:0043628)2.74054902
136nuclear pore complex assembly (GO:0051292)2.73779243
137intracellular lipid transport (GO:0032365)2.72471360
138dendrite morphogenesis (GO:0048813)2.72280362
139postsynaptic membrane organization (GO:0001941)2.70379064
140ephrin receptor signaling pathway (GO:0048013)2.70084758
141heart field specification (GO:0003128)2.69818497
142secondary heart field specification (GO:0003139)2.69818497
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66488417
144metanephric mesenchyme development (GO:0072075)2.64958220
145positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.64611395
146nuclear pore organization (GO:0006999)2.63928429
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63807381
148detection of light stimulus involved in visual perception (GO:0050908)2.62664089
149detection of light stimulus involved in sensory perception (GO:0050962)2.62664089
150neuromuscular process controlling balance (GO:0050885)2.62466393
151lens development in camera-type eye (GO:0002088)2.61824736
152regulation of synaptic plasticity (GO:0048167)2.60946385
153neurotransmitter-gated ion channel clustering (GO:0072578)2.60636983
154IMP metabolic process (GO:0046040)2.60076382
155neuron-neuron synaptic transmission (GO:0007270)2.59162400
156behavioral fear response (GO:0001662)2.58751735
157behavioral defense response (GO:0002209)2.58751735
158regulation of vascular permeability (GO:0043114)2.58655455
159central nervous system projection neuron axonogenesis (GO:0021952)2.58220319
160pre-miRNA processing (GO:0031054)2.57006262
161positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.55238485
162response to auditory stimulus (GO:0010996)2.53596047
163long-term memory (GO:0007616)2.53022746
164digestive system process (GO:0022600)2.52263493
165proline transport (GO:0015824)2.52193121
166mesonephros development (GO:0001823)2.51685260
167regulation of skeletal muscle contraction (GO:0014819)2.50547538
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50016212
169skeletal muscle organ development (GO:0060538)2.49022291
170signal complex assembly (GO:0007172)2.48950462
171regulation of heart morphogenesis (GO:2000826)2.46852828
172peptidyl-histidine modification (GO:0018202)2.46621849
173regulation of axon extension involved in axon guidance (GO:0048841)2.46372886
174positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46069208
175synapse assembly (GO:0007416)2.45988920
176otic vesicle formation (GO:0030916)2.45576321
177mesenchymal to epithelial transition (GO:0060231)2.44200208
178long-term synaptic potentiation (GO:0060291)2.43545398
179ventricular trabecula myocardium morphogenesis (GO:0003222)2.42966784
180neuronal action potential propagation (GO:0019227)2.42937703
181axon extension involved in axon guidance (GO:0048846)2.42684139
182neuron projection extension involved in neuron projection guidance (GO:1902284)2.42684139
183regulation of skeletal muscle cell differentiation (GO:2001014)2.42391852
184positive regulation of multicellular organismal metabolic process (GO:0044253)2.42371907
185planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41609781
186mitotic G2/M transition checkpoint (GO:0044818)2.40545889
187cellular response to electrical stimulus (GO:0071257)2.40408840
188regulation of nitric-oxide synthase activity (GO:0050999)2.40250059
189cell surface receptor signaling pathway involved in heart development (GO:0061311)2.39512179
190kidney mesenchyme development (GO:0072074)2.38564509
191regulation of postsynaptic membrane potential (GO:0060078)2.38306865
192hindlimb morphogenesis (GO:0035137)2.37715926
193cell migration in hindbrain (GO:0021535)2.36989624
194positive regulation of gastrulation (GO:2000543)2.36694260
195synapse organization (GO:0050808)2.35461456
196regulation of axon guidance (GO:1902667)2.34795633
197heart valve formation (GO:0003188)2.34523102
198C4-dicarboxylate transport (GO:0015740)2.34200806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.32018037
2EZH2_22144423_ChIP-Seq_EOC_Human5.04850352
3IGF1R_20145208_ChIP-Seq_DFB_Human3.33225376
4VDR_22108803_ChIP-Seq_LS180_Human2.97408788
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94164477
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.78570161
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69916117
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69916117
9GBX2_23144817_ChIP-Seq_PC3_Human2.66037887
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64555129
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61534317
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.56105304
13ZNF263_19887448_ChIP-Seq_K562_Human2.49791658
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48816987
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47849938
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45740481
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44526004
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.41985312
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40496401
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.35536989
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31339330
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.28738138
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27999255
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.15134440
25EWS_26573619_Chip-Seq_HEK293_Human2.14600825
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10972661
27* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00254043
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99098832
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97754525
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.96476179
31DROSHA_22980978_ChIP-Seq_HELA_Human1.93186648
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89713977
33AR_21572438_ChIP-Seq_LNCaP_Human1.89546114
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.89111246
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88010435
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86547034
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.84596721
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.83723331
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.83658448
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79987960
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.79577984
42FUS_26573619_Chip-Seq_HEK293_Human1.78962099
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76639879
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76305942
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76142884
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73255558
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67827228
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66326325
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.66263484
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65421284
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64415573
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64058626
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.63258001
54REST_21632747_ChIP-Seq_MESCs_Mouse1.60962041
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60286031
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58436668
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.58163049
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55782177
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.55053692
60AR_21909140_ChIP-Seq_LNCAP_Human1.54988078
61TP53_16413492_ChIP-PET_HCT116_Human1.54853182
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54443510
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50774891
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50337746
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49540599
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48772317
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48216026
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45800237
69SMAD4_21799915_ChIP-Seq_A2780_Human1.44617716
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.43323640
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42485931
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42318663
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40577240
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40538706
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40538706
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39325747
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38526592
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38506520
79TAF15_26573619_Chip-Seq_HEK293_Human1.37426115
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.36934296
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36520818
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36306468
83RXR_22108803_ChIP-Seq_LS180_Human1.35468903
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34562982
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34491544
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33268599
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.30527321
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.29147828
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.29056988
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.28677828
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.28381769
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26260999
93P300_19829295_ChIP-Seq_ESCs_Human1.26186582
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.25027701
95AHR_22903824_ChIP-Seq_MCF-7_Human1.24983851
96GATA3_24758297_ChIP-Seq_MCF-7_Human1.23881190
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.23330165
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.23073039
99AR_19668381_ChIP-Seq_PC3_Human1.22307531
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21490686
101ZNF274_21170338_ChIP-Seq_K562_Hela1.20867859
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20641053
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.20592688
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20232504
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19871487
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.19544125
107* TBL1_22424771_ChIP-Seq_293T_Human1.19339782
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18865869
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18280901
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17912404
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17698024
112* NFYB_21822215_ChIP-Seq_K562_Human1.17457021
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17367591
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.16689769
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.16342074
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.16220406
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16020636
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15670710
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14117340
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14099107
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13728086
122EGR1_19374776_ChIP-ChIP_THP-1_Human1.12495354
123* HNFA_21074721_ChIP-Seq_CACO-2_Human1.12079524
124AR_25329375_ChIP-Seq_VCAP_Human1.12074630
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11821029
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10802681
127TP53_18474530_ChIP-ChIP_U2OS_Human1.10203794
128* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07087598
129MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07020375
130* STAT3_23295773_ChIP-Seq_U87_Human1.06781704
131CBP_20019798_ChIP-Seq_JUKART_Human1.06739852
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06739852
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.06732969
134* KDM2B_26808549_Chip-Seq_K562_Human1.06300745
135GATA1_22025678_ChIP-Seq_K562_Human1.06292595
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06243343
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05314825
138CBP_21632823_ChIP-Seq_H3396_Human1.05266910
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05221793
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04787651
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04629279
142ESR2_21235772_ChIP-Seq_MCF-7_Human1.04448567
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03608576
144PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03278820
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02507800
146* SMAD3_21741376_ChIP-Seq_ESCs_Human1.02394052
147E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01223420
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00955466
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00955466
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99597530
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99158366
152HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98154303
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97344452
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94563074
155* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93904464
156TCF4_23295773_ChIP-Seq_U87_Human0.93684047
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92631440
158* NFYA_21822215_ChIP-Seq_K562_Human0.92425538
159FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90591975
160TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90564514
161* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90279898
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89556028
163ESET_19884257_ChIP-Seq_ESCs_Mouse0.88498358
164SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87712265
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85427933
166* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85082681
167ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84447246
168CHD1_26751641_Chip-Seq_LNCaP_Human0.84284104
169* RNF2_27304074_Chip-Seq_NSC_Mouse0.83114556
170BRD4_25478319_ChIP-Seq_HGPS_Human0.82126580
171* CDX2_22108803_ChIP-Seq_LS180_Human0.81678728
172EZH2_27294783_Chip-Seq_NPCs_Mouse0.81606672
173FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81532518
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81222481
175* PHF8_20622853_ChIP-Seq_HELA_Human0.81038480
176FOXA1_25552417_ChIP-Seq_VCAP_Human0.80944942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system6.28615879
2MP0004859_abnormal_synaptic_plasticity5.30388572
3MP0000013_abnormal_adipose_tissue4.98660551
4MP0009379_abnormal_foot_pigmentation3.74380950
5MP0003880_abnormal_central_pattern2.88262282
6MP0003656_abnormal_erythrocyte_physiolo2.76699461
7MP0003635_abnormal_synaptic_transmissio2.74057732
8MP0002009_preneoplasia2.64856209
9MP0000749_muscle_degeneration2.61955030
10MP0001485_abnormal_pinna_reflex2.43283686
11MP0004270_analgesia2.37274422
12MP0002063_abnormal_learning/memory/cond2.34913542
13MP0003136_yellow_coat_color2.32218590
14MP0000003_abnormal_adipose_tissue2.27710878
15MP0003879_abnormal_hair_cell2.24385361
16MP0004858_abnormal_nervous_system2.23391521
17MP0002234_abnormal_pharynx_morphology2.22627552
18MP0001486_abnormal_startle_reflex2.21052895
19MP0008057_abnormal_DNA_replication2.20505102
20MP0000383_abnormal_hair_follicle2.20103598
21MP0002653_abnormal_ependyma_morphology2.16369762
22MP0000778_abnormal_nervous_system2.14768605
23MP0002249_abnormal_larynx_morphology2.06542646
24MP0010030_abnormal_orbit_morphology1.97823136
25MP0009697_abnormal_copulation1.97697732
26MP0009745_abnormal_behavioral_response1.94172772
27MP0005623_abnormal_meninges_morphology1.92955964
28MP0003878_abnormal_ear_physiology1.92492109
29MP0005377_hearing/vestibular/ear_phenot1.92492109
30MP0004885_abnormal_endolymph1.90746527
31MP0000049_abnormal_middle_ear1.87761682
32MP0004215_abnormal_myocardial_fiber1.86160896
33MP0003941_abnormal_skin_development1.79701393
34MP0010352_gastrointestinal_tract_polyps1.78139262
35MP0002572_abnormal_emotion/affect_behav1.71664092
36MP0001664_abnormal_digestion1.68625965
37MP0000534_abnormal_ureter_morphology1.66817689
38MP0003123_paternal_imprinting1.65626143
39MP0010094_abnormal_chromosome_stability1.61497013
40MP0002160_abnormal_reproductive_system1.58471269
41MP0009780_abnormal_chondrocyte_physiolo1.58136594
42MP0002064_seizures1.56135004
43MP0001188_hyperpigmentation1.55981333
44MP0001968_abnormal_touch/_nociception1.52565551
45MP0001293_anophthalmia1.52401832
46MP0004808_abnormal_hematopoietic_stem1.51732506
47MP0003119_abnormal_digestive_system1.51699143
48MP0004233_abnormal_muscle_weight1.51489401
49MP0000026_abnormal_inner_ear1.48974862
50MP0003567_abnormal_fetal_cardiomyocyte1.48926012
51MP0004957_abnormal_blastocyst_morpholog1.48785681
52MP0003942_abnormal_urinary_system1.48110683
53MP0003329_amyloid_beta_deposits1.46782155
54MP0001963_abnormal_hearing_physiology1.45873014
55MP0002127_abnormal_cardiovascular_syste1.44182740
56MP0002736_abnormal_nociception_after1.43651259
57MP0002272_abnormal_nervous_system1.43550107
58MP0003938_abnormal_ear_development1.42132463
59MP0002184_abnormal_innervation1.39500481
60MP0001501_abnormal_sleep_pattern1.39443117
61MP0005551_abnormal_eye_electrophysiolog1.35133422
62MP0000537_abnormal_urethra_morphology1.32923291
63MP0001440_abnormal_grooming_behavior1.32517592
64MP0005187_abnormal_penis_morphology1.31656253
65MP0003111_abnormal_nucleus_morphology1.30905782
66MP0003861_abnormal_nervous_system1.29577588
67MP0006036_abnormal_mitochondrial_physio1.29140001
68MP0009053_abnormal_anal_canal1.28436699
69MP0002152_abnormal_brain_morphology1.22346824
70MP0003115_abnormal_respiratory_system1.19815828
71MP0000631_abnormal_neuroendocrine_gland1.19681242
72MP0003315_abnormal_perineum_morphology1.18390851
73MP0009250_abnormal_appendicular_skeleto1.16924832
74MP0002734_abnormal_mechanical_nocicepti1.16871757
75MP0005409_darkened_coat_color1.16531580
76MP0002233_abnormal_nose_morphology1.16408519
77MP0002882_abnormal_neuron_morphology1.15515088
78MP0002877_abnormal_melanocyte_morpholog1.15265939
79MP0003937_abnormal_limbs/digits/tail_de1.14763111
80MP0002254_reproductive_system_inflammat1.14588227
81MP0005375_adipose_tissue_phenotype1.13645406
82MP0008569_lethality_at_weaning1.13536819
83MP0001765_abnormal_ion_homeostasis1.12567171
84MP0005646_abnormal_pituitary_gland1.11509980
85MP0000955_abnormal_spinal_cord1.10783984
86MP0003755_abnormal_palate_morphology1.10403304
87MP0003283_abnormal_digestive_organ1.08804859
88MP0002067_abnormal_sensory_capabilities1.08473446
89MP0003718_maternal_effect1.07726297
90MP0002084_abnormal_developmental_patter1.06682366
91MP0000428_abnormal_craniofacial_morphol1.06496860
92MP0001299_abnormal_eye_distance/1.05779326
93MP0003943_abnormal_hepatobiliary_system1.05326882
94MP0002971_abnormal_brown_adipose1.04910409
95MP0002088_abnormal_embryonic_growth/wei1.04097737
96MP0002557_abnormal_social/conspecific_i1.03624719
97MP0003935_abnormal_craniofacial_develop1.02251622
98MP0003984_embryonic_growth_retardation1.01519989
99MP0002098_abnormal_vibrissa_morphology1.00860594
100MP0003385_abnormal_body_wall0.99444204
101MP0001849_ear_inflammation0.99122677
102MP0000678_abnormal_parathyroid_gland0.97310361
103MP0008058_abnormal_DNA_repair0.97183071
104MP0003787_abnormal_imprinting0.95883298
105MP0005380_embryogenesis_phenotype0.95048455
106MP0001672_abnormal_embryogenesis/_devel0.95048455
107MP0002116_abnormal_craniofacial_bone0.94949392
108MP0005248_abnormal_Harderian_gland0.94367883
109MP0001346_abnormal_lacrimal_gland0.93769045
110MP0008007_abnormal_cellular_replicative0.93436341
111MP0000566_synostosis0.90901164
112MP0005636_abnormal_mineral_homeostasis0.90685908
113MP0009643_abnormal_urine_homeostasis0.89841487
114MP0003121_genomic_imprinting0.89261895
115MP0002089_abnormal_postnatal_growth/wei0.88960113
116MP0000762_abnormal_tongue_morphology0.88899801
117MP0004147_increased_porphyrin_level0.88541429
118MP0009703_decreased_birth_body0.88435269
119MP0002085_abnormal_embryonic_tissue0.88410947
120MP0002752_abnormal_somatic_nervous0.88265178
121MP0005423_abnormal_somatic_nervous0.87963522
122MP0004811_abnormal_neuron_physiology0.87693734
123MP0010234_abnormal_vibrissa_follicle0.87585665
124MP0005332_abnormal_amino_acid0.85073713
125MP0002932_abnormal_joint_morphology0.84667258
126MP0002735_abnormal_chemical_nociception0.84145907
127MP0004484_altered_response_of0.84068645
128MP0002066_abnormal_motor_capabilities/c0.83678522
129MP0003705_abnormal_hypodermis_morpholog0.83531969
130MP0006292_abnormal_olfactory_placode0.82995731
131MP0005334_abnormal_fat_pad0.82882447
132MP0004264_abnormal_extraembryonic_tissu0.81959076
133MP0004145_abnormal_muscle_electrophysio0.81932485
134MP0001666_abnormal_nutrient_absorption0.81567717
135MP0000751_myopathy0.80377015
136MP0001730_embryonic_growth_arrest0.79462946
137MP0001177_atelectasis0.79098771
138MP0010630_abnormal_cardiac_muscle0.78532080
139MP0003122_maternal_imprinting0.78448159
140MP0002086_abnormal_extraembryonic_tissu0.77277457
141MP0004133_heterotaxia0.77235326
142MP0006072_abnormal_retinal_apoptosis0.76709448
143MP0002837_dystrophic_cardiac_calcinosis0.76507358
144MP0002177_abnormal_outer_ear0.76208400
145MP0009672_abnormal_birth_weight0.76170843
146MP0002733_abnormal_thermal_nociception0.75829088
147MP0002282_abnormal_trachea_morphology0.75571350
148MP0005394_taste/olfaction_phenotype0.75458249
149MP0005499_abnormal_olfactory_system0.75458249
150MP0002697_abnormal_eye_size0.75127408
151MP0004197_abnormal_fetal_growth/weight/0.74602371
152MP0002081_perinatal_lethality0.74540519
153MP0000759_abnormal_skeletal_muscle0.74269250
154MP0001286_abnormal_eye_development0.74107093
155MP0010678_abnormal_skin_adnexa0.73686728
156MP0004272_abnormal_basement_membrane0.73206231
157MP0005253_abnormal_eye_physiology0.73186934
158MP0003077_abnormal_cell_cycle0.72822610
159MP0000733_abnormal_muscle_development0.72770106
160MP0003252_abnormal_bile_duct0.72459075
161MP0004087_abnormal_muscle_fiber0.72081611
162MP0000350_abnormal_cell_proliferation0.71176080
163MP0002106_abnormal_muscle_physiology0.70574213
164MP0001697_abnormal_embryo_size0.69098455
165MP0008877_abnormal_DNA_methylation0.68522113
166MP0003632_abnormal_nervous_system0.67748913
167MP0000627_abnormal_mammary_gland0.67536583
168MP0010368_abnormal_lymphatic_system0.66888900
169MP0009115_abnormal_fat_cell0.66747350
170MP0002114_abnormal_axial_skeleton0.66591783
171MP0004084_abnormal_cardiac_muscle0.65633391
172MP0005385_cardiovascular_system_phenoty0.65414379
173MP0001544_abnormal_cardiovascular_syste0.65414379
174MP0003693_abnormal_embryo_hatching0.65277161
175MP0005670_abnormal_white_adipose0.64967910
176MP0005666_abnormal_adipose_tissue0.62630964
177MP0000462_abnormal_digestive_system0.62548807
178MP0004085_abnormal_heartbeat0.61671226
179MP0005220_abnormal_exocrine_pancreas0.61412372
180MP0000467_abnormal_esophagus_morphology0.60384705
181MP0004036_abnormal_muscle_relaxation0.60262793

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)7.10567230
2Hypoglycemic seizures (HP:0002173)6.74420515
3Male infertility (HP:0003251)6.73397688
4Generalized aminoaciduria (HP:0002909)6.20681365
5Hypophosphatemic rickets (HP:0004912)5.73448958
6Abnormality of the costochondral junction (HP:0000919)5.59806773
7Renal Fanconi syndrome (HP:0001994)5.11344439
8Symptomatic seizures (HP:0011145)4.62224885
9Hyperphosphatemia (HP:0002905)4.57129140
10Tetany (HP:0001281)4.35519070
11Recurrent corneal erosions (HP:0000495)4.24372979
12Polydipsia (HP:0001959)4.01345592
13Abnormal drinking behavior (HP:0030082)4.01345592
14Bundle branch block (HP:0011710)3.96324838
15Acute lymphatic leukemia (HP:0006721)3.82479697
16Hyponatremia (HP:0002902)3.81773550
17Delayed puberty (HP:0000823)3.53994344
18Synostosis involving the elbow (HP:0003938)3.36890315
19Humeroradial synostosis (HP:0003041)3.36890315
20Hypokalemia (HP:0002900)3.31548484
21Focal motor seizures (HP:0011153)3.30876287
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.26509590
23Relative macrocephaly (HP:0004482)3.22810385
24Abnormality of calcium-phosphate metabolism (HP:0100530)3.21767023
25Abnormality of renal resorption (HP:0011038)3.18335718
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.16735822
27Exocrine pancreatic insufficiency (HP:0001738)3.16102274
28Abnormality of fatty-acid metabolism (HP:0004359)3.08191173
29Hyperinsulinemic hypoglycemia (HP:0000825)3.07966320
30Subaortic stenosis (HP:0001682)3.05464871
31Abnormality of the left ventricular outflow tract (HP:0011103)3.05464871
32Type I diabetes mellitus (HP:0100651)2.97597043
33Abnormality of sodium homeostasis (HP:0010931)2.94329882
34Oligodactyly (HP:0012165)2.92931381
35Abnormality of alanine metabolism (HP:0010916)2.92388357
36Hyperalaninemia (HP:0003348)2.92388357
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92388357
38Midline defect of the nose (HP:0004122)2.80418268
39Aplasia involving bones of the extremities (HP:0009825)2.80219093
40Aplasia involving bones of the upper limbs (HP:0009823)2.80219093
41Aplasia of the phalanges of the hand (HP:0009802)2.80219093
42Abnormality of potassium homeostasis (HP:0011042)2.78571172
43Myokymia (HP:0002411)2.76305316
44Glycosuria (HP:0003076)2.75890056
45Abnormality of urine glucose concentration (HP:0011016)2.75890056
46Focal seizures (HP:0007359)2.73433599
47Megalencephaly (HP:0001355)2.72187948
48Short 4th metacarpal (HP:0010044)2.71710065
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71710065
50Abnormality of small intestinal villus morphology (HP:0011472)2.68609599
51Villous atrophy (HP:0011473)2.68609599
52Exercise-induced myalgia (HP:0003738)2.65214248
53Rickets (HP:0002748)2.58620545
54Mixed hearing impairment (HP:0000410)2.58229399
55Polyuria (HP:0000103)2.57443859
56Epileptic encephalopathy (HP:0200134)2.52978547
57Distal arthrogryposis (HP:0005684)2.47927539
58Abnormality of the pubic bones (HP:0003172)2.45645721
59Shallow orbits (HP:0000586)2.40091244
60Muscle fiber inclusion bodies (HP:0100299)2.40006790
61Syncope (HP:0001279)2.36362304
62Atrioventricular block (HP:0001678)2.36259686
63Heart block (HP:0012722)2.34918701
64Nemaline bodies (HP:0003798)2.34200443
65Pheochromocytoma (HP:0002666)2.30865298
66Esophageal atresia (HP:0002032)2.30467978
67Acute myeloid leukemia (HP:0004808)2.27850903
68Anophthalmia (HP:0000528)2.27514487
69Abnormality of the antihelix (HP:0009738)2.26609368
70Increased serum pyruvate (HP:0003542)2.25676224
71Abnormal urine output (HP:0012590)2.25185897
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25008522
73Anomalous pulmonary venous return (HP:0010772)2.24272602
74Abnormality of the 4th metacarpal (HP:0010012)2.22339362
75Abnormality of the pulmonary veins (HP:0011718)2.19051646
76Abnormality of the nasolacrimal system (HP:0000614)2.18506763
77Mesangial abnormality (HP:0001966)2.16451483
78Portal hypertension (HP:0001409)2.15432028
79Decreased testicular size (HP:0008734)2.15300920
80Exostoses (HP:0100777)2.13445260
81Aqueductal stenosis (HP:0002410)2.13189119
82Skull defect (HP:0001362)2.12519956
83Ependymoma (HP:0002888)2.10729969
84Muscle hypertrophy of the lower extremities (HP:0008968)2.09862846
85Supernumerary bones of the axial skeleton (HP:0009144)2.09136426
86Rhabdomyolysis (HP:0003201)2.07948689
87Abnormality of renal excretion (HP:0011036)2.06063640
88Febrile seizures (HP:0002373)2.05800010
89Cupped ear (HP:0000378)2.04633058
90Abnormal atrioventricular conduction (HP:0005150)2.04517317
91Astrocytoma (HP:0009592)2.04289986
92Abnormality of the astrocytes (HP:0100707)2.04289986
93Cerebral inclusion bodies (HP:0100314)2.03652646
94Asymmetry of the thorax (HP:0001555)2.03606333
95Cutaneous finger syndactyly (HP:0010554)2.02767076
96Abnormality of glycolysis (HP:0004366)2.01892334
97Hypoparathyroidism (HP:0000829)2.00873217
98Abnormality of the hepatic vasculature (HP:0006707)1.99254080
99Asymmetric septal hypertrophy (HP:0001670)1.99166985
100Myoglobinuria (HP:0002913)1.98897986
101Bilateral microphthalmos (HP:0007633)1.98098231
102Shawl scrotum (HP:0000049)1.97190323
103Coronal craniosynostosis (HP:0004440)1.96825783
104Tubulointerstitial nephritis (HP:0001970)1.96411245
105Calf muscle hypertrophy (HP:0008981)1.94837414
106Atonic seizures (HP:0010819)1.94806634
107Hepatoblastoma (HP:0002884)1.94031794
108Oligodactyly (hands) (HP:0001180)1.94020167
109Neoplasm of the heart (HP:0100544)1.93435694
110Broad-based gait (HP:0002136)1.92690485
111Right ventricular cardiomyopathy (HP:0011663)1.92209023
112Annular pancreas (HP:0001734)1.91668716
113Alacrima (HP:0000522)1.91364304
114Abnormality of the labia minora (HP:0012880)1.90603709
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.90569831
116Trigonocephaly (HP:0000243)1.90283020
117Cystic hygroma (HP:0000476)1.88812297
118Action tremor (HP:0002345)1.88234406
119Abnormality of the lower motor neuron (HP:0002366)1.87529591
120Abnormality of the lacrimal duct (HP:0011481)1.86432050
121Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85766863
122Visual hallucinations (HP:0002367)1.84192474
123Renal duplication (HP:0000075)1.83143265
124Metabolic acidosis (HP:0001942)1.82978888
125Cutaneous syndactyly (HP:0012725)1.81381488
126Abnormality of cochlea (HP:0000375)1.81352048
127Calcaneovalgus deformity (HP:0001848)1.80657956
128Hemiparesis (HP:0001269)1.80624634
129Morphological abnormality of the middle ear (HP:0008609)1.79975458
130Diplopia (HP:0000651)1.78720705
131Abnormality of binocular vision (HP:0011514)1.78720705
132Palpitations (HP:0001962)1.77702255
133Arnold-Chiari malformation (HP:0002308)1.77587619
134Partial agenesis of the corpus callosum (HP:0001338)1.76564728
135Hemivertebrae (HP:0002937)1.74741995
136Decreased lacrimation (HP:0000633)1.74290424
137Progressive cerebellar ataxia (HP:0002073)1.74145504
138Germ cell neoplasia (HP:0100728)1.73718114
139Pancreatic islet-cell hyperplasia (HP:0004510)1.73685962
140Broad metatarsal (HP:0001783)1.73477789
141Abnormality of the middle phalanges of the toes (HP:0010183)1.73346811
142Supernumerary ribs (HP:0005815)1.72978897
143Ankyloglossia (HP:0010296)1.72521706
144Hyperactive renin-angiotensin system (HP:0000841)1.72188743
145Choanal stenosis (HP:0000452)1.72078000
146Pointed chin (HP:0000307)1.72068729
147Bronchomalacia (HP:0002780)1.72008411
148Renal hypoplasia (HP:0000089)1.71999288
149Bell-shaped thorax (HP:0001591)1.71510468
150Neuroendocrine neoplasm (HP:0100634)1.71129602
151Hypoplasia of the ulna (HP:0003022)1.70535106
152Partial duplication of the phalanx of hand (HP:0009999)1.69567290
153Abnormality of the calf musculature (HP:0001430)1.69136098
154Arterial tortuosity (HP:0005116)1.68859523
155Narrow palate (HP:0000189)1.68449111
156Occipital encephalocele (HP:0002085)1.68161582
157Abnormality of the diencephalon (HP:0010662)1.67884527
158Gastrointestinal atresia (HP:0002589)1.67629925
159Amblyopia (HP:0000646)1.66838305
160Papillary thyroid carcinoma (HP:0002895)1.66525630
161Truncal obesity (HP:0001956)1.66198282
162Glioma (HP:0009733)1.64918729
163Unilateral renal agenesis (HP:0000122)1.64623048
164Hypophosphatemia (HP:0002148)1.64597741
165Bicornuate uterus (HP:0000813)1.63615163
166Urethral obstruction (HP:0000796)1.63537662
167Atrial fibrillation (HP:0005110)1.63110044
168Absence seizures (HP:0002121)1.62938973
169Thyroid carcinoma (HP:0002890)1.62779391
170Hypoglycemic coma (HP:0001325)1.62745780
171Hypoplastic nipples (HP:0002557)1.62496152
172Vertebral arch anomaly (HP:0008438)1.62326226
173Sandal gap (HP:0001852)1.61543030
174Drooling (HP:0002307)1.61503922
175Excessive salivation (HP:0003781)1.61503922
176Synostosis of carpal bones (HP:0005048)1.60287396
177Infertility (HP:0000789)1.59820820
178Missing ribs (HP:0000921)1.59682702
179Obsessive-compulsive behavior (HP:0000722)1.59550146
180Abnormality of vitamin B metabolism (HP:0004340)1.56267848
181Deformed tarsal bones (HP:0008119)1.56262663
182Congenital primary aphakia (HP:0007707)1.55980038
183Gout (HP:0001997)1.55789710
184Turricephaly (HP:0000262)1.55045524
185Renal dysplasia (HP:0000110)1.54336997
186Partial duplication of thumb phalanx (HP:0009944)1.53803660
187Hydroureter (HP:0000072)1.53781377
188Multiple enchondromatosis (HP:0005701)1.53154403
189Dialeptic seizures (HP:0011146)1.53011022
190Central scotoma (HP:0000603)1.52205293
191Insomnia (HP:0100785)1.52027946
192Median cleft lip (HP:0000161)1.51086926
193Abnormality of the vitamin B12 metabolism (HP:0004341)1.49909480
194Medial flaring of the eyebrow (HP:0010747)1.49553025
195Anosmia (HP:0000458)1.48871238
196Hyperkalemia (HP:0002153)1.47402547
197Genital tract atresia (HP:0001827)1.45043086
198Gastrointestinal stroma tumor (HP:0100723)1.44957122
199Striae distensae (HP:0001065)1.43989897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT36.85528425
2SCYL26.33623978
3PRKG24.84992002
4EPHA44.61065518
5NTRK34.13631311
6PRKD34.09081077
7DDR23.04063358
8KSR22.75430968
9KIT2.74880154
10KSR12.63531316
11OBSCN2.61027627
12ACVR1B2.47647373
13MAP3K42.37708828
14MAP3K92.29839229
15PNCK2.24896100
16MKNK22.17222473
17RPS6KB22.14906838
18CSF1R1.94803931
19MKNK11.94208514
20LATS11.88939270
21PAK61.84070932
22MINK11.81618020
23MAP3K101.79777039
24MAPK131.78519005
25TTK1.78461808
26RIPK41.63847790
27TYRO31.62101834
28DAPK21.60357348
29LATS21.58699980
30PASK1.56238481
31PLK21.54526949
32PDK21.49887026
33MST1R1.43571269
34IKBKE1.43340855
35FGR1.41527622
36NTRK11.35754850
37CAMK1G1.35350981
38EPHB21.34376893
39BLK1.34259755
40EIF2AK31.34149630
41RAF11.32610829
42CASK1.28489410
43MARK11.27780094
44NTRK21.27690403
45PTK2B1.25717314
46STK31.24499384
47CDK121.23455539
48BMPR1B1.19921572
49STK391.17833869
50FGFR31.13690367
51BRD41.12711970
52TNIK1.12156606
53CAMK2D1.12102782
54MARK31.10450183
55DMPK1.08611994
56DAPK11.08603485
57PAK31.07978465
58PLK41.06107724
59FGFR11.06002899
60STK101.04442749
61FRK1.04184446
62MST41.02345059
63PDGFRA1.00850547
64BRSK20.99767951
65CDK50.99026145
66MAP2K40.98615114
67PBK0.94996080
68STK380.92899806
69WEE10.92258519
70NME10.92234220
71MAP3K10.90413975
72PRKD20.84977229
73GRK60.84955243
74MAP2K70.84099124
75EEF2K0.83096119
76LMTK20.83066400
77CAMKK10.80755380
78FES0.78079226
79SIK20.77447814
80CHEK20.77420010
81STK110.76253432
82NUAK10.74905105
83GRK50.74498446
84MAP3K70.74310853
85PLK30.74176822
86ERBB30.72894067
87TTN0.72884747
88TAOK20.72810476
89RIPK10.71593736
90CAMK1D0.70804781
91PRKCH0.70694498
92ZAP700.70296943
93DYRK1A0.69482314
94ATM0.68615295
95RPS6KB10.67753635
96PRKCG0.66546355
97CAMK2A0.63989334
98RET0.63975428
99MAP3K130.63097269
100PLK10.62994671
101PAK20.61814493
102ERBB20.61516247
103PHKG20.61444142
104PHKG10.61444142
105FGFR20.61285065
106ZAK0.61101617
107MAP3K20.59817061
108FER0.59456892
109ROCK20.59179793
110PRKAA20.59000451
111RPS6KA30.58703390
112STK40.57499497
113TSSK60.55807382
114SGK10.55690597
115TRPM70.55596668
116AURKB0.55203981
117CAMK2B0.55031486
118PIK3CG0.54593569
119CSNK1G20.54221783
120ALK0.52949139
121ATR0.52615118
122PDGFRB0.51775730
123MET0.51669685
124STK240.51554963
125PAK40.50732496
126CDK140.50397411
127CDK150.50272228
128CDK180.49916875
129MAPK100.48538748
130MAP2K10.47960633
131WNK40.47495214
132TRIB30.47003995
133OXSR10.46272542
134CDC70.46033489
135EIF2AK10.45989786
136INSRR0.45830153
137BMX0.45774619
138UHMK10.45691034
139CAMK10.45437294
140PIK3CA0.45238599
141NEK10.44814512
142CDK30.44684191
143CLK10.44229366
144PRKDC0.43190127
145VRK10.43165204
146PRKAA10.42680570
147CDC42BPA0.42300374
148CDK11A0.41766978
149DYRK1B0.41725159
150BMPR20.41577336
151SGK30.41003818
152CSNK1E0.40227637
153STK38L0.39725682
154SGK20.39311190
155CDK70.39183033
156CDK60.38365672
157CDK20.36948723
158FYN0.36393865
159GSK3B0.35845597
160SRC0.35379246
161MAP4K20.34935543
162BUB10.34558184
163PRPF4B0.34203932
164NLK0.34020516
165MARK20.33940085
166RPS6KL10.33419100
167RPS6KC10.33419100
168CSNK1D0.33351857
169PINK10.32440306
170YES10.31359599
171GRK10.31124442
172CCNB10.30758683
173EPHA20.28079722
174CDK10.27932726
175CHEK10.25936396
176RPS6KA60.25480103

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.76900220
2Nitrogen metabolism_Homo sapiens_hsa009103.33867372
3One carbon pool by folate_Homo sapiens_hsa006702.84305209
4Long-term potentiation_Homo sapiens_hsa047202.73680278
5Nicotine addiction_Homo sapiens_hsa050332.70993002
6Circadian entrainment_Homo sapiens_hsa047132.25120800
7Glutamatergic synapse_Homo sapiens_hsa047242.15890589
8Amphetamine addiction_Homo sapiens_hsa050312.15039204
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.08513760
10Fat digestion and absorption_Homo sapiens_hsa049751.90081931
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87207469
12Olfactory transduction_Homo sapiens_hsa047401.87046042
13Morphine addiction_Homo sapiens_hsa050321.82569885
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80137724
15Salivary secretion_Homo sapiens_hsa049701.78852528
16Gastric acid secretion_Homo sapiens_hsa049711.73722913
17Melanogenesis_Homo sapiens_hsa049161.73618188
18Dopaminergic synapse_Homo sapiens_hsa047281.72297212
19DNA replication_Homo sapiens_hsa030301.68471130
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64278134
21GABAergic synapse_Homo sapiens_hsa047271.63900917
22Renin secretion_Homo sapiens_hsa049241.63309607
23Non-homologous end-joining_Homo sapiens_hsa034501.61284609
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59531894
25Long-term depression_Homo sapiens_hsa047301.55777892
26Axon guidance_Homo sapiens_hsa043601.55103690
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54164342
28Vitamin digestion and absorption_Homo sapiens_hsa049771.53592396
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52224978
30Calcium signaling pathway_Homo sapiens_hsa040201.49705170
31Basal cell carcinoma_Homo sapiens_hsa052171.49528592
32Fatty acid degradation_Homo sapiens_hsa000711.49047984
33GnRH signaling pathway_Homo sapiens_hsa049121.48564472
34Oxytocin signaling pathway_Homo sapiens_hsa049211.46698333
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45624353
36Cholinergic synapse_Homo sapiens_hsa047251.44998965
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44104528
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42941456
39Glioma_Homo sapiens_hsa052141.42771794
40Mismatch repair_Homo sapiens_hsa034301.42228755
41Dorso-ventral axis formation_Homo sapiens_hsa043201.40909914
42Pyruvate metabolism_Homo sapiens_hsa006201.37852847
43Hippo signaling pathway_Homo sapiens_hsa043901.37809745
44Ribosome_Homo sapiens_hsa030101.37601243
45Insulin secretion_Homo sapiens_hsa049111.36686908
46Sulfur metabolism_Homo sapiens_hsa009201.33925381
47Arginine biosynthesis_Homo sapiens_hsa002201.30891023
48Wnt signaling pathway_Homo sapiens_hsa043101.30507683
49Gap junction_Homo sapiens_hsa045401.29957580
50Synaptic vesicle cycle_Homo sapiens_hsa047211.29373343
51Estrogen signaling pathway_Homo sapiens_hsa049151.28509755
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27363806
53Propanoate metabolism_Homo sapiens_hsa006401.24005322
54cAMP signaling pathway_Homo sapiens_hsa040241.22899718
55RNA transport_Homo sapiens_hsa030131.21968565
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21377018
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20665410
58Oocyte meiosis_Homo sapiens_hsa041141.20566230
59Taste transduction_Homo sapiens_hsa047421.18332845
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18059646
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17670158
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14648920
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13944787
64Cocaine addiction_Homo sapiens_hsa050301.13936097
65Nucleotide excision repair_Homo sapiens_hsa034201.13197533
66Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09255337
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08346328
68Adipocytokine signaling pathway_Homo sapiens_hsa049201.08026749
69Serotonergic synapse_Homo sapiens_hsa047261.05854547
70ErbB signaling pathway_Homo sapiens_hsa040121.05818243
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04846536
72Fatty acid metabolism_Homo sapiens_hsa012121.00107972
73Homologous recombination_Homo sapiens_hsa034401.00073954
74Rap1 signaling pathway_Homo sapiens_hsa040150.99688070
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99202395
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98576667
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98368397
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95941783
79VEGF signaling pathway_Homo sapiens_hsa043700.95075918
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.94899377
81Choline metabolism in cancer_Homo sapiens_hsa052310.94474229
82Butanoate metabolism_Homo sapiens_hsa006500.93544629
83TGF-beta signaling pathway_Homo sapiens_hsa043500.93381683
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.92832613
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91987274
86Dilated cardiomyopathy_Homo sapiens_hsa054140.91928006
87Adherens junction_Homo sapiens_hsa045200.91813547
88Linoleic acid metabolism_Homo sapiens_hsa005910.91501139
89Renin-angiotensin system_Homo sapiens_hsa046140.91299892
90Cell cycle_Homo sapiens_hsa041100.90524645
91Colorectal cancer_Homo sapiens_hsa052100.89802320
92Glucagon signaling pathway_Homo sapiens_hsa049220.89050820
93RNA degradation_Homo sapiens_hsa030180.87210296
94Hedgehog signaling pathway_Homo sapiens_hsa043400.86229338
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86226688
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83943417
97Proteoglycans in cancer_Homo sapiens_hsa052050.83576718
98Fatty acid biosynthesis_Homo sapiens_hsa000610.82924444
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82862024
100Thyroid hormone synthesis_Homo sapiens_hsa049180.81250631
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.80928133
102Purine metabolism_Homo sapiens_hsa002300.80780861
103Protein digestion and absorption_Homo sapiens_hsa049740.80563560
104Endometrial cancer_Homo sapiens_hsa052130.79084164
105Base excision repair_Homo sapiens_hsa034100.78833563
106Carbon metabolism_Homo sapiens_hsa012000.78199297
107Histidine metabolism_Homo sapiens_hsa003400.76106150
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.76031690
109N-Glycan biosynthesis_Homo sapiens_hsa005100.76018501
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75822382
111mTOR signaling pathway_Homo sapiens_hsa041500.75218885
112Notch signaling pathway_Homo sapiens_hsa043300.74407252
113Cardiac muscle contraction_Homo sapiens_hsa042600.74306586
114Starch and sucrose metabolism_Homo sapiens_hsa005000.73802098
115Focal adhesion_Homo sapiens_hsa045100.72311980
116Renal cell carcinoma_Homo sapiens_hsa052110.70154639
117Tight junction_Homo sapiens_hsa045300.69669188
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69501648
119Type II diabetes mellitus_Homo sapiens_hsa049300.69416284
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69075206
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68996714
122Ras signaling pathway_Homo sapiens_hsa040140.68554884
123Non-small cell lung cancer_Homo sapiens_hsa052230.67643726
124MAPK signaling pathway_Homo sapiens_hsa040100.66601037
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66134438
126Folate biosynthesis_Homo sapiens_hsa007900.65941462
127Glutathione metabolism_Homo sapiens_hsa004800.65884586
128Arginine and proline metabolism_Homo sapiens_hsa003300.64866145
129Inositol phosphate metabolism_Homo sapiens_hsa005620.62747383
130African trypanosomiasis_Homo sapiens_hsa051430.62708752
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62004554
132Bladder cancer_Homo sapiens_hsa052190.61233012
133MicroRNAs in cancer_Homo sapiens_hsa052060.60586042
134Melanoma_Homo sapiens_hsa052180.59367183
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58873548
136Insulin signaling pathway_Homo sapiens_hsa049100.58742803
137Phototransduction_Homo sapiens_hsa047440.58646606
138Glycerolipid metabolism_Homo sapiens_hsa005610.58539189
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57307496
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57245293
141Pathways in cancer_Homo sapiens_hsa052000.56921699
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56785248
143beta-Alanine metabolism_Homo sapiens_hsa004100.56059917
144ECM-receptor interaction_Homo sapiens_hsa045120.55348706
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55143982
146Thyroid cancer_Homo sapiens_hsa052160.55081445
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54750811
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54431699
149Circadian rhythm_Homo sapiens_hsa047100.53775546
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.53417550
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52914303
152Ether lipid metabolism_Homo sapiens_hsa005650.51502727
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49295686
154Selenocompound metabolism_Homo sapiens_hsa004500.49002967
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.48570072
156mRNA surveillance pathway_Homo sapiens_hsa030150.48541111
157Pancreatic secretion_Homo sapiens_hsa049720.47764954
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47721895
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47698624
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46685272
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.45883888
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44804326
163Tyrosine metabolism_Homo sapiens_hsa003500.44498984
164Bile secretion_Homo sapiens_hsa049760.44494355
165Chemical carcinogenesis_Homo sapiens_hsa052040.43516678
166Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41859288
167Tryptophan metabolism_Homo sapiens_hsa003800.41738154
168AMPK signaling pathway_Homo sapiens_hsa041520.40450691
169Metabolic pathways_Homo sapiens_hsa011000.40293960
170Insulin resistance_Homo sapiens_hsa049310.40253210
171Biosynthesis of amino acids_Homo sapiens_hsa012300.39756302
172PPAR signaling pathway_Homo sapiens_hsa033200.39588978
173Platelet activation_Homo sapiens_hsa046110.38880288

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