RAX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction (GO:0007602)8.40760740
2detection of light stimulus (GO:0009583)7.92608089
3GMP metabolic process (GO:0046037)7.64078215
4detection of light stimulus involved in visual perception (GO:0050908)7.58292374
5detection of light stimulus involved in sensory perception (GO:0050962)7.58292374
6planar cell polarity pathway involved in neural tube closure (GO:0090179)7.55931508
7neuron remodeling (GO:0016322)7.52680333
8phototransduction, visible light (GO:0007603)7.49975870
9* visual perception (GO:0007601)7.45196507
10* sensory perception of light stimulus (GO:0050953)7.35529346
11convergent extension (GO:0060026)7.26902170
12detection of visible light (GO:0009584)7.26517649
13peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.16626476
14eye photoreceptor cell differentiation (GO:0001754)7.03772307
15photoreceptor cell differentiation (GO:0046530)7.03772307
16regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)6.91542991
17retina development in camera-type eye (GO:0060041)6.89734526
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)6.86203150
19ribosomal small subunit assembly (GO:0000028)6.09645940
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.95484348
21protein-chromophore linkage (GO:0018298)5.89703593
22ribosomal small subunit biogenesis (GO:0042274)5.80487643
23viral transcription (GO:0019083)5.79150650
24regulation of non-canonical Wnt signaling pathway (GO:2000050)5.72418459
25cardiac left ventricle morphogenesis (GO:0003214)5.58752507
26translational termination (GO:0006415)5.56360141
27Wnt signaling pathway, planar cell polarity pathway (GO:0060071)5.55262603
28negative regulation of cell fate specification (GO:0009996)5.50985600
29detection of external stimulus (GO:0009581)5.48401683
30maturation of SSU-rRNA (GO:0030490)5.44532489
31detection of abiotic stimulus (GO:0009582)5.37541671
32regulation of clathrin-mediated endocytosis (GO:2000369)5.24670985
33regulation of establishment of planar polarity (GO:0090175)5.21543990
34cellular response to light stimulus (GO:0071482)5.07406555
35substrate-dependent cell migration (GO:0006929)4.99265826
36negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.96664496
37positive regulation of gastrulation (GO:2000543)4.90151995
38outer ear morphogenesis (GO:0042473)4.81870590
39pre-miRNA processing (GO:0031054)4.80346608
40regulation of gene silencing by RNA (GO:0060966)4.76997830
41regulation of posttranscriptional gene silencing (GO:0060147)4.76997830
42regulation of gene silencing by miRNA (GO:0060964)4.76997830
43paraxial mesoderm development (GO:0048339)4.66844780
44neuronal stem cell maintenance (GO:0097150)4.65843689
45regulation of mesoderm development (GO:2000380)4.60393043
46cell proliferation in forebrain (GO:0021846)4.56243991
47heterochromatin organization (GO:0070828)4.56140141
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53725074
49cotranslational protein targeting to membrane (GO:0006613)4.52675311
50positive regulation of guanylate cyclase activity (GO:0031284)4.50871027
51protein targeting to ER (GO:0045047)4.43115651
52translational elongation (GO:0006414)4.41021153
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.38225393
54kinetochore assembly (GO:0051382)4.36816213
55non-canonical Wnt signaling pathway (GO:0035567)4.36625973
56kinetochore organization (GO:0051383)4.35222208
57regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32338454
58negative regulation of JUN kinase activity (GO:0043508)4.31242512
59synaptic vesicle maturation (GO:0016188)4.30189299
60cellular protein complex disassembly (GO:0043624)4.26100046
61establishment of protein localization to endoplasmic reticulum (GO:0072599)4.24182296
62positive regulation of catenin import into nucleus (GO:0035413)4.23948612
63somite rostral/caudal axis specification (GO:0032525)4.21823765
64regulation of cell fate specification (GO:0042659)4.20999551
65short-term memory (GO:0007614)4.19078318
66retina layer formation (GO:0010842)4.15164465
67viral life cycle (GO:0019058)4.12366045
68protein localization to endoplasmic reticulum (GO:0070972)4.10590882
69neuron fate determination (GO:0048664)4.06534594
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.05522093
71chromatin remodeling at centromere (GO:0031055)4.04949399
72negative regulation of striated muscle cell apoptotic process (GO:0010664)4.04102190
73protein complex disassembly (GO:0043241)4.00667957
74mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.99985813
75regulation of guanylate cyclase activity (GO:0031282)3.99791164
76primitive streak formation (GO:0090009)3.92846820
77negative regulation of cell fate commitment (GO:0010454)3.91647392
78notochord development (GO:0030903)3.87559815
79L-serine metabolic process (GO:0006563)3.81138323
80neuron development (GO:0048666)3.80578659
81negative regulation of receptor-mediated endocytosis (GO:0048261)3.73657700
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.73439108
83macromolecular complex disassembly (GO:0032984)3.67572717
84hematopoietic stem cell proliferation (GO:0071425)3.63884632
85G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.63229341
86translational initiation (GO:0006413)3.60659123
87nonmotile primary cilium assembly (GO:0035058)3.55006372
88CENP-A containing nucleosome assembly (GO:0034080)3.52768525
89positive regulation of vesicle fusion (GO:0031340)3.50023226
90post-anal tail morphogenesis (GO:0036342)3.46930440
91epithelial cell fate commitment (GO:0072148)3.41469631
92* sensory perception (GO:0007600)3.41020637
93digestive tract morphogenesis (GO:0048546)3.38564378
94ribosomal large subunit biogenesis (GO:0042273)3.37423702
95negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.33137399
96somite development (GO:0061053)3.31146753
97response to light stimulus (GO:0009416)3.30038264
98estrogen biosynthetic process (GO:0006703)3.29065543
99olfactory bulb development (GO:0021772)3.26748653
100cellular response to radiation (GO:0071478)3.25941104
101lipoprotein transport (GO:0042953)3.24783920
102regulation of cardiac muscle cell apoptotic process (GO:0010665)3.23431500
103pituitary gland development (GO:0021983)3.22065705
104radial glial cell differentiation (GO:0060019)3.19807789
105neuron maturation (GO:0042551)3.15549142
106tongue development (GO:0043586)3.14858750
107chaperone-mediated protein transport (GO:0072321)3.13151440
108protein localization to synapse (GO:0035418)3.10583787
109positive regulation of transcription regulatory region DNA binding (GO:2000679)3.09541996
110regulation of cGMP metabolic process (GO:0030823)3.09176860
111protein targeting to membrane (GO:0006612)3.07199886
112mitotic chromosome condensation (GO:0007076)3.07036910
113nuclear-transcribed mRNA catabolic process (GO:0000956)3.06839530
114histone exchange (GO:0043486)3.06352262
115nephron tubule morphogenesis (GO:0072078)3.05159106
116nephron epithelium morphogenesis (GO:0072088)3.05159106
117response to X-ray (GO:0010165)3.03877284
118regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.03045145
119regulation of striated muscle cell apoptotic process (GO:0010662)3.02856372
120layer formation in cerebral cortex (GO:0021819)3.01485467
121ncRNA catabolic process (GO:0034661)3.00466081
122positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.00276165
123CDP-diacylglycerol biosynthetic process (GO:0016024)2.98676209
124positive regulation of RNA splicing (GO:0033120)2.95823341
125cardiovascular system development (GO:0072358)2.94887871
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.94355159
127cytokinetic process (GO:0032506)2.92819900
128DNA replication-independent nucleosome assembly (GO:0006336)2.92754196
129DNA replication-independent nucleosome organization (GO:0034724)2.92754196
130histone H3-K9 demethylation (GO:0033169)2.90781165
131mRNA catabolic process (GO:0006402)2.90699732
132regulation of stem cell maintenance (GO:2000036)2.86487384
133ribonucleoprotein complex biogenesis (GO:0022613)2.86037085
134sodium ion export (GO:0071436)2.85308782
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83946624
136chromatin assembly (GO:0031497)2.82211260
137chondrocyte development (GO:0002063)2.81745993
138genitalia morphogenesis (GO:0035112)2.81020362
139retinoid metabolic process (GO:0001523)2.79259198
140ATP-dependent chromatin remodeling (GO:0043044)2.79239735
141maternal placenta development (GO:0001893)2.79165222
142embryonic digestive tract development (GO:0048566)2.78899455
143RNA catabolic process (GO:0006401)2.78828236
144regulation of type B pancreatic cell apoptotic process (GO:2000674)2.78773128
145negative regulation of embryonic development (GO:0045992)2.77450582
146developmental induction (GO:0031128)2.76854774
147intestinal epithelial cell development (GO:0060576)2.74255532
148adaptation of signaling pathway (GO:0023058)2.72919357
149regulation of neuroblast proliferation (GO:1902692)2.72236423
150behavioral response to nicotine (GO:0035095)2.71229739
151positive regulation of respiratory burst (GO:0060267)2.69989605
152cell-cell signaling involved in cell fate commitment (GO:0045168)2.69214651
153mesenchymal to epithelial transition (GO:0060231)2.68084146
154cochlea morphogenesis (GO:0090103)2.66022036
155CDP-diacylglycerol metabolic process (GO:0046341)2.64909539
156neural tube closure (GO:0001843)2.63953636
157response to pheromone (GO:0019236)2.63939407
158forebrain neuron differentiation (GO:0021879)2.61554441
159apoptotic process involved in development (GO:1902742)2.61208030
160tube closure (GO:0060606)2.60678214
161retina homeostasis (GO:0001895)2.59391805
162peptidyl-lysine dimethylation (GO:0018027)2.58701555
163regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.58178316
164potassium ion import (GO:0010107)2.58145554
165diterpenoid metabolic process (GO:0016101)2.57714289
166neuron fate commitment (GO:0048663)2.55886473
167vasculature development (GO:0001944)2.55586308
168positive regulation of cGMP biosynthetic process (GO:0030828)2.55365356
169telomere maintenance via semi-conservative replication (GO:0032201)2.55004822
170negative regulation of JAK-STAT cascade (GO:0046426)2.53874779
171embryonic body morphogenesis (GO:0010172)2.53508609
172ganglion development (GO:0061548)2.50336680
173cellular potassium ion homeostasis (GO:0030007)2.48871846
174vitamin A metabolic process (GO:0006776)2.48823355
175negative regulation of histone methylation (GO:0031061)2.47535539
176negative regulation of hormone metabolic process (GO:0032351)2.47146364
177negative regulation of hormone biosynthetic process (GO:0032353)2.47146364
178oocyte development (GO:0048599)2.46796602
179glandular epithelial cell differentiation (GO:0002067)2.45184793
180positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.44656812
181cerebellum development (GO:0021549)2.43587817
182innervation (GO:0060384)2.41920859
183dorsal/ventral axis specification (GO:0009950)2.39310842
184positive regulation of hormone biosynthetic process (GO:0046886)2.39303903
185dendritic spine morphogenesis (GO:0060997)2.36932119
186terpenoid metabolic process (GO:0006721)2.36381774
187membrane repolarization (GO:0086009)2.36228444
188regulation of synaptic vesicle exocytosis (GO:2000300)2.36206218
189axoneme assembly (GO:0035082)2.36193901
190histone demethylation (GO:0016577)2.35304850
191regulation of cGMP biosynthetic process (GO:0030826)2.35011310
192retinal cone cell development (GO:0046549)11.9772635
193photoreceptor cell development (GO:0042461)11.9089174
194retinal rod cell development (GO:0046548)11.7264293
195eye photoreceptor cell development (GO:0042462)11.3022001
196photoreceptor cell maintenance (GO:0045494)10.9965794
197regulation of rhodopsin mediated signaling pathway (GO:0022400)10.8613801
198rhodopsin mediated signaling pathway (GO:0016056)10.5258221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.77509216
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.03315488
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.19637658
4E2F7_22180533_ChIP-Seq_HELA_Human3.86150794
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.25798031
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24507478
7CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.24436695
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01797317
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.94963862
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.73956047
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62356433
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.60715875
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.60715875
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.60715875
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58586973
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.56819641
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.48246135
18IRF1_19129219_ChIP-ChIP_H3396_Human2.39386690
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37093908
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36743184
21KDM2B_26808549_Chip-Seq_K562_Human2.33987319
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.18673148
23XRN2_22483619_ChIP-Seq_HELA_Human2.12585280
24KDM2B_26808549_Chip-Seq_JURKAT_Human2.10496239
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.09933459
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04703750
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.04465715
28EZH2_22144423_ChIP-Seq_EOC_Human2.03267479
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00909493
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95922662
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95304741
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91626520
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.90322683
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88222024
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87964249
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86641886
37TTF2_22483619_ChIP-Seq_HELA_Human1.85766305
38* RING1B_27294783_Chip-Seq_NPCs_Mouse1.84748553
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83079370
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.82028605
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81307632
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79421904
43KDM2B_26808549_Chip-Seq_DND41_Human1.76327002
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75368372
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75222285
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.75052145
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.74215229
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.70707449
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70399033
50* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70133747
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69648782
52* SOX2_16153702_ChIP-ChIP_HESCs_Human1.69519330
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67587023
54CTCF_27219007_Chip-Seq_Bcells_Human1.64937724
55* MYC_18940864_ChIP-ChIP_HL60_Human1.64852487
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63611366
57* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62989315
58CREB1_26743006_Chip-Seq_LNCaP_Human1.61748981
59* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60626299
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60181628
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59699866
62* NANOG_16153702_ChIP-ChIP_HESCs_Human1.59055932
63* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58292002
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.57827348
65* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55883632
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.55459539
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50823162
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49733038
69* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49433775
70* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49433775
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48768680
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.48680023
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.43744067
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42358754
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.41353177
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39561767
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38730044
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38644767
79* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38056615
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37319575
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37031865
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.35812030
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34687848
84* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31420122
85MYC_22102868_ChIP-Seq_BL_Human1.31344228
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29301594
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28897143
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.28618999
89* RNF2_27304074_Chip-Seq_ESCs_Mouse1.28599506
90* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27853456
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27709796
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27258048
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25759386
94REST_21632747_ChIP-Seq_MESCs_Mouse1.24787301
95* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23916527
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23768026
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23055507
98* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23007724
99SMC4_20622854_ChIP-Seq_HELA_Human1.21815511
100* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21312681
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.20568881
102* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20350544
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.19519950
104* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19450574
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19316226
106TCF7_22412390_ChIP-Seq_EML_Mouse1.19287610
107RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17904506
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.17598379
109* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16969664
110FOXP3_21729870_ChIP-Seq_TREG_Human1.16211959
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15929353
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15457757
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14563940
114* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14493793
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12726746
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12580270
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11949559
118* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11823880
119NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10827194
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09303286
121CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08830922
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08643191
123* TP53_20018659_ChIP-ChIP_R1E_Mouse1.08426076
124AR_21909140_ChIP-Seq_LNCAP_Human1.08057043
125* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06735877
126RNF2_27304074_Chip-Seq_NSC_Mouse1.06339431
127DROSHA_22980978_ChIP-Seq_HELA_Human1.06256468
128* CBX2_27304074_Chip-Seq_ESCs_Mouse1.05845131
129IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05702722
130CHD1_26751641_Chip-Seq_LNCaP_Human1.05355130
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04592585
132* EZH2_27304074_Chip-Seq_ESCs_Mouse1.04266794
133* EED_16625203_ChIP-ChIP_MESCs_Mouse1.03568177
134* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01788193
135* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01169928
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00594523
137* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99864007
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99481376
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99442917
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99345832
141POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99272287
142SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99131101
143POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.98869708
144CLOCK_20551151_ChIP-Seq_293T_Human0.97737604
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97560356
146P68_20966046_ChIP-Seq_HELA_Human0.97014553
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96705988
148* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96496295
149* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96064420
150ELK1_19687146_ChIP-ChIP_HELA_Human0.95357685
151* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94856623
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94651081
153* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94512596
154* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92182530
155LXR_22292898_ChIP-Seq_THP-1_Human0.91798099
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89907648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.81022769
2MP0003011_delayed_dark_adaptation7.66330095
3MP0006072_abnormal_retinal_apoptosis7.60251263
4MP0009379_abnormal_foot_pigmentation6.24479848
5MP0005253_abnormal_eye_physiology6.18443270
6MP0006292_abnormal_olfactory_placode4.19790426
7MP0002653_abnormal_ependyma_morphology4.15107953
8* MP0005195_abnormal_posterior_eye3.91389416
9MP0005377_hearing/vestibular/ear_phenot3.66279244
10MP0003878_abnormal_ear_physiology3.66279244
11MP0001324_abnormal_eye_pigmentation3.40168028
12* MP0005391_vision/eye_phenotype3.27222113
13MP0010030_abnormal_orbit_morphology3.05596133
14MP0003136_yellow_coat_color2.77986230
15MP0001348_abnormal_lacrimal_gland2.68011236
16MP0008789_abnormal_olfactory_epithelium2.66457853
17MP0005394_taste/olfaction_phenotype2.57000374
18MP0005499_abnormal_olfactory_system2.57000374
19MP0002638_abnormal_pupillary_reflex2.33115259
20MP0002229_neurodegeneration2.25169206
21MP0003937_abnormal_limbs/digits/tail_de2.21295234
22MP0004885_abnormal_endolymph2.17747837
23MP0000566_synostosis2.14269477
24MP0003693_abnormal_embryo_hatching2.10131812
25MP0003122_maternal_imprinting2.09800872
26MP0009053_abnormal_anal_canal2.07659535
27MP0002938_white_spotting2.04045505
28MP0003123_paternal_imprinting1.97362581
29MP0002090_abnormal_vision1.96664117
30* MP0002752_abnormal_somatic_nervous1.91308355
31MP0002234_abnormal_pharynx_morphology1.82685578
32* MP0001502_abnormal_circadian_rhythm1.81566954
33MP0003890_abnormal_embryonic-extraembry1.80999590
34MP0003950_abnormal_plasma_membrane1.77551424
35MP0003938_abnormal_ear_development1.73165713
36MP0002111_abnormal_tail_morphology1.67064592
37MP0005248_abnormal_Harderian_gland1.55331533
38MP0002882_abnormal_neuron_morphology1.51318146
39MP0001485_abnormal_pinna_reflex1.45454180
40MP0002249_abnormal_larynx_morphology1.41585976
41MP0003787_abnormal_imprinting1.40369027
42MP0000778_abnormal_nervous_system1.39580287
43* MP0003755_abnormal_palate_morphology1.37807214
44MP0005197_abnormal_uvea_morphology1.31959722
45MP0003942_abnormal_urinary_system1.28649872
46MP0009672_abnormal_birth_weight1.26847281
47MP0005423_abnormal_somatic_nervous1.24589877
48MP0003315_abnormal_perineum_morphology1.23847785
49* MP0002697_abnormal_eye_size1.23195707
50MP0003121_genomic_imprinting1.21688313
51MP0005187_abnormal_penis_morphology1.21612517
52* MP0001286_abnormal_eye_development1.20172128
53MP0004957_abnormal_blastocyst_morpholog1.18257544
54MP0003705_abnormal_hypodermis_morpholog1.18180020
55MP0000026_abnormal_inner_ear1.14842941
56MP0003111_abnormal_nucleus_morphology1.11458599
57MP0001299_abnormal_eye_distance/1.10915712
58MP0000631_abnormal_neuroendocrine_gland0.97742234
59MP0002127_abnormal_cardiovascular_syste0.97347484
60MP0003634_abnormal_glial_cell0.95993458
61MP0003567_abnormal_fetal_cardiomyocyte0.94397997
62MP0002109_abnormal_limb_morphology0.94186301
63MP0008932_abnormal_embryonic_tissue0.93658581
64MP0008877_abnormal_DNA_methylation0.93315737
65MP0000432_abnormal_head_morphology0.91576624
66MP0001849_ear_inflammation0.90783126
67MP0008058_abnormal_DNA_repair0.89270548
68MP0005174_abnormal_tail_pigmentation0.87016345
69MP0010094_abnormal_chromosome_stability0.86607201
70MP0002210_abnormal_sex_determination0.81410938
71MP0003385_abnormal_body_wall0.80695511
72MP0009703_decreased_birth_body0.80511373
73MP0001145_abnormal_male_reproductive0.80052006
74MP0005670_abnormal_white_adipose0.77327248
75MP0003077_abnormal_cell_cycle0.76845307
76MP0000428_abnormal_craniofacial_morphol0.76625919
77MP0004270_analgesia0.75934362
78MP0009780_abnormal_chondrocyte_physiolo0.75426188
79MP0005380_embryogenesis_phenotype0.74090187
80MP0001672_abnormal_embryogenesis/_devel0.74090187
81MP0002751_abnormal_autonomic_nervous0.73857278
82MP0000653_abnormal_sex_gland0.73752744
83* MP0001293_anophthalmia0.72756844
84MP0001340_abnormal_eyelid_morphology0.72275631
85MP0004233_abnormal_muscle_weight0.72058269
86* MP0003861_abnormal_nervous_system0.70458790
87MP0002932_abnormal_joint_morphology0.69819209
88MP0005076_abnormal_cell_differentiation0.69595681
89MP0003283_abnormal_digestive_organ0.69356557
90MP0001915_intracranial_hemorrhage0.69329707
91MP0009278_abnormal_bone_marrow0.68741881
92MP0003119_abnormal_digestive_system0.68053247
93MP0002114_abnormal_axial_skeleton0.67295696
94MP0001984_abnormal_olfaction0.67145584
95* MP0002152_abnormal_brain_morphology0.66934629
96MP0004859_abnormal_synaptic_plasticity0.66032794
97MP0006276_abnormal_autonomic_nervous0.65742976
98MP0004858_abnormal_nervous_system0.64369840
99MP0001764_abnormal_homeostasis0.63195466
100MP0003984_embryonic_growth_retardation0.60105863
101MP0003936_abnormal_reproductive_system0.58522934
102MP0002233_abnormal_nose_morphology0.58169989
103MP0003115_abnormal_respiratory_system0.57582239
104MP0001486_abnormal_startle_reflex0.57558282
105MP0000534_abnormal_ureter_morphology0.57478318
106MP0000465_gastrointestinal_hemorrhage0.57471335
107MP0003635_abnormal_synaptic_transmissio0.56991525
108MP0002088_abnormal_embryonic_growth/wei0.56384817
109* MP0002092_abnormal_eye_morphology0.55981274
110MP0001529_abnormal_vocalization0.55922854
111MP0000762_abnormal_tongue_morphology0.55543977
112MP0000537_abnormal_urethra_morphology0.55077419
113MP0010234_abnormal_vibrissa_follicle0.53981033
114MP0000955_abnormal_spinal_cord0.52839733
115MP0010386_abnormal_urinary_bladder0.52803369
116MP0000049_abnormal_middle_ear0.48467747
117* MP0005193_abnormal_anterior_eye0.48215541
118MP0002184_abnormal_innervation0.47020195
119MP0002272_abnormal_nervous_system0.46863494
120MP0001346_abnormal_lacrimal_gland0.46315717
121MP0004811_abnormal_neuron_physiology0.45900815
122MP0003880_abnormal_central_pattern0.45479998
123MP0002064_seizures0.45330655
124MP0005257_abnormal_intraocular_pressure0.44338496
125MP0002067_abnormal_sensory_capabilities0.42527728
126MP0003935_abnormal_craniofacial_develop0.42411484
127MP0005220_abnormal_exocrine_pancreas0.41230196
128MP0000733_abnormal_muscle_development0.40506054
129MP0004019_abnormal_vitamin_homeostasis0.39223200
130MP0002063_abnormal_learning/memory/cond0.38981456
131MP0008004_abnormal_stomach_pH0.37771795
132* MP0002081_perinatal_lethality0.36999335
133MP0002734_abnormal_mechanical_nocicepti0.35536048
134MP0001963_abnormal_hearing_physiology0.34738349
135MP0004782_abnormal_surfactant_physiolog0.34221819
136MP0003632_abnormal_nervous_system0.34218196
137MP0002066_abnormal_motor_capabilities/c0.33085265
138MP0004197_abnormal_fetal_growth/weight/0.32909411
139MP0001879_abnormal_lymphatic_vessel0.32859013
140MP0002557_abnormal_social/conspecific_i0.32239774
141MP0002089_abnormal_postnatal_growth/wei0.30955557
142MP0008007_abnormal_cellular_replicative0.27504165
143* MP0002085_abnormal_embryonic_tissue0.26934848
144MP0001614_abnormal_blood_vessel0.26856386
145MP0003633_abnormal_nervous_system0.26854084
146MP0002116_abnormal_craniofacial_bone0.26298253
147MP0001944_abnormal_pancreas_morphology0.26128981
148MP0010770_preweaning_lethality0.25702035
149MP0002082_postnatal_lethality0.25702035
150MP0002084_abnormal_developmental_patter0.25669775
151MP0004084_abnormal_cardiac_muscle0.25616351
152MP0008961_abnormal_basal_metabolism0.24798287
153MP0005623_abnormal_meninges_morphology0.24550281
154MP0004142_abnormal_muscle_tone0.24279184
155MP0004145_abnormal_muscle_electrophysio0.24165045
156MP0002332_abnormal_exercise_endurance0.23827143
157MP0001697_abnormal_embryo_size0.23128815

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.30378063
2Chorioretinal atrophy (HP:0000533)9.17663179
3Bony spicule pigmentary retinopathy (HP:0007737)8.78192319
4Congenital stationary night blindness (HP:0007642)8.67738259
5Posterior subcapsular cataract (HP:0007787)8.59436518
6Abolished electroretinogram (ERG) (HP:0000550)8.58575746
7Central scotoma (HP:0000603)8.47274182
8Pigmentary retinal degeneration (HP:0001146)8.29604730
9Scotoma (HP:0000575)7.10674646
10Dyschromatopsia (HP:0007641)7.00058075
11Abnormality of macular pigmentation (HP:0008002)6.59773956
12Aplasia/Hypoplasia of the sacrum (HP:0008517)5.74647798
13Severe visual impairment (HP:0001141)5.72851672
14Decreased central vision (HP:0007663)5.55615958
15Vitreoretinal degeneration (HP:0000655)5.52168616
16Cone-rod dystrophy (HP:0000548)5.39422827
17Type II diabetes mellitus (HP:0005978)5.38459715
18Macular degeneration (HP:0000608)5.24111240
19Constricted visual fields (HP:0001133)5.17398110
20Subcapsular cataract (HP:0000523)5.13691750
21Reticulocytopenia (HP:0001896)5.11594224
22Rib fusion (HP:0000902)5.10461378
23Missing ribs (HP:0000921)5.01970045
24Increased corneal curvature (HP:0100692)4.98926233
25Keratoconus (HP:0000563)4.98926233
26Attenuation of retinal blood vessels (HP:0007843)4.88694643
27Photophobia (HP:0000613)4.85310234
28Partial duplication of thumb phalanx (HP:0009944)4.21425113
2911 pairs of ribs (HP:0000878)4.00719779
30Broad thumb (HP:0011304)3.56515402
31Partial duplication of the phalanx of hand (HP:0009999)3.55459906
32Thoracolumbar scoliosis (HP:0002944)3.46745020
33Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.28746049
34Retinitis pigmentosa (HP:0000510)3.28319138
35Renal duplication (HP:0000075)3.25614485
36Hemivertebrae (HP:0002937)3.20543393
37Short middle phalanx of the 5th finger (HP:0004220)3.11967426
38Progressive visual loss (HP:0000529)3.09931144
39Bifid tongue (HP:0010297)3.09115878
40Choroideremia (HP:0001139)3.02195246
41* Anophthalmia (HP:0000528)3.01532618
42High anterior hairline (HP:0009890)3.00167653
43Duplication of thumb phalanx (HP:0009942)3.00096459
44Broad phalanges of the hand (HP:0009768)2.92415219
45Abnormality of the phalanges of the 5th finger (HP:0004213)2.90441260
46Diastasis recti (HP:0001540)2.84896225
47Hepatoblastoma (HP:0002884)2.84205617
48Polar cataract (HP:0010696)2.83901254
49Urethral obstruction (HP:0000796)2.78713715
50Synostosis of carpal bones (HP:0005048)2.77685918
51Broad finger (HP:0001500)2.75482310
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.72345184
53Macrocytic anemia (HP:0001972)2.72324024
54Metaphyseal cupping (HP:0003021)2.69961337
55Preaxial foot polydactyly (HP:0001841)2.69147184
56Absent thumb (HP:0009777)2.66350521
57Hypoplastic pelvis (HP:0008839)2.64910192
58Abnormality of cells of the erythroid lineage (HP:0012130)2.62283636
59Ectopic kidney (HP:0000086)2.60316551
60Broad phalanx (HP:0006009)2.59497348
61Renal dysplasia (HP:0000110)2.58498590
62Septo-optic dysplasia (HP:0100842)2.53518843
63Short 5th finger (HP:0009237)2.50658943
64Short middle phalanx of finger (HP:0005819)2.46728438
65Hypoplastic ischia (HP:0003175)2.46608161
66Stenosis of the external auditory canal (HP:0000402)2.46375195
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.46158539
68Abdominal situs inversus (HP:0003363)2.45704026
69Abnormality of abdominal situs (HP:0011620)2.45704026
70Vertebral clefting (HP:0008428)2.41031057
71Wide nasal bridge (HP:0000431)2.39749884
72Broad long bones (HP:0005622)2.38061367
73Rectovaginal fistula (HP:0000143)2.37160596
74Rectal fistula (HP:0100590)2.37160596
75Abnormality of the 4th metacarpal (HP:0010012)2.30815343
76Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.25627306
77Abnormality of the calcaneus (HP:0008364)2.22270913
78Triphalangeal thumb (HP:0001199)2.19886285
79Mesomelia (HP:0003027)2.17054048
80Abnormal vertebral ossification (HP:0100569)2.14684567
81Aplasia/Hypoplasia of the macula (HP:0008059)2.13158762
82Vertebral hypoplasia (HP:0008417)2.11084024
83Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.11084024
84Meckel diverticulum (HP:0002245)2.10056375
85Cutaneous finger syndactyly (HP:0010554)2.09933399
86Cutaneous syndactyly (HP:0012725)2.09094285
87Broad toe (HP:0001837)2.08741334
88Abnormality of cochlea (HP:0000375)2.08455595
89Oligodactyly (HP:0012165)2.07317487
90Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07197232
91Abnormality of the nasal septum (HP:0000419)2.07031247
92Optic disc pallor (HP:0000543)2.06840550
93Pallor (HP:0000980)2.04367697
94Supernumerary ribs (HP:0005815)2.04251406
95Intestinal fistula (HP:0100819)2.03875812
96Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01902581
97Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.01347086
98Carpal synostosis (HP:0009702)2.00279980
99Absent rod-and cone-mediated responses on ERG (HP:0007688)10.9856053
100Pendular nystagmus (HP:0012043)10.4929785
101Intestinal atresia (HP:0011100)1.99488375
102Abnormality of the ileum (HP:0001549)1.98744706
103Adrenal hypoplasia (HP:0000835)1.98336638
104Hypoplasia of the ulna (HP:0003022)1.97776239
105Abnormality of the ischium (HP:0003174)1.95911460
106Irregular epiphyses (HP:0010582)1.95074782
107Vaginal fistula (HP:0004320)1.93701913
108Supernumerary bones of the axial skeleton (HP:0009144)1.93240907
109Interstitial pulmonary disease (HP:0006530)1.92222672
110Renal hypoplasia (HP:0000089)1.92115152
111Oligodactyly (hands) (HP:0001180)1.91097815
112Horseshoe kidney (HP:0000085)1.90673471
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.89379283
114Enlarged kidneys (HP:0000105)1.88029695
115Broad palm (HP:0001169)1.87070413
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86867255
117Short 4th metacarpal (HP:0010044)1.86867255
118Chromsome breakage (HP:0040012)1.86057989
119Bicornuate uterus (HP:0000813)1.85844588
120Esophageal atresia (HP:0002032)1.85151688
121Short thumb (HP:0009778)1.84982871
122Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84380141
123Bilateral microphthalmos (HP:0007633)1.81549184
124Forearm undergrowth (HP:0009821)1.81243795
125Choanal stenosis (HP:0000452)1.80257446
126Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79695615
127Abnormality of the right ventricle (HP:0001707)1.79301686
128Abnormal number of erythroid precursors (HP:0012131)1.79232097
129Severe Myopia (HP:0011003)1.74250542
130Abnormality of the lower motor neuron (HP:0002366)1.68936265
131Retinal atrophy (HP:0001105)1.66045943
132Gait imbalance (HP:0002141)1.62350816
133Insomnia (HP:0100785)1.61548206
134Buphthalmos (HP:0000557)1.57923300
135Congenital primary aphakia (HP:0007707)1.57835929
136Horizontal nystagmus (HP:0000666)1.53367210
137Maternal diabetes (HP:0009800)1.51207373
138* Sclerocornea (HP:0000647)1.50290363
139Optic atrophy (HP:0000648)1.50253339
140Aplasia/Hypoplasia of the lens (HP:0008063)1.48207259
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.44936892
142Congenital sensorineural hearing impairment (HP:0008527)1.43082464
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.41900242
144Optic nerve hypoplasia (HP:0000609)1.37983425
145Absent septum pellucidum (HP:0001331)1.36874286
146Nephrogenic diabetes insipidus (HP:0009806)1.32366839
147Elfin facies (HP:0004428)1.25640236
148Abnormality of the septum pellucidum (HP:0007375)1.21711280
149Congenital glaucoma (HP:0001087)1.21301483
150Hyperacusis (HP:0010780)1.20972699
151Pancreatic fibrosis (HP:0100732)1.20712192
152True hermaphroditism (HP:0010459)1.20161620
153Abnormality of the parathyroid morphology (HP:0011766)1.18478943
154Retinal detachment (HP:0000541)1.17224108
155Medial flaring of the eyebrow (HP:0010747)1.16352995
156Poor coordination (HP:0002370)1.14150096
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.12542491
158Cystic liver disease (HP:0006706)1.12470088
159Renovascular hypertension (HP:0100817)1.12120480
160Visual hallucinations (HP:0002367)1.11489310
161Dysdiadochokinesis (HP:0002075)1.09179886
162Abnormality of the fovea (HP:0000493)1.08554032
163Vaginal atresia (HP:0000148)1.06994218
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.01740914
165Hypoplasia of the fovea (HP:0007750)1.01740914
166Genital tract atresia (HP:0001827)1.01380815
167Colon cancer (HP:0003003)1.01351411
168Chorioretinal coloboma (HP:0000567)1.01291481
169Supranuclear gaze palsy (HP:0000605)1.00549757
170Holoprosencephaly (HP:0001360)0.99506774
171Hypermetropia (HP:0000540)0.99200307
172Microcornea (HP:0000482)0.98898543
173Recurrent sinusitis (HP:0011108)0.96746418
174Macroorchidism (HP:0000053)0.95420803
175Anencephaly (HP:0002323)0.94473438
176Pseudobulbar signs (HP:0002200)0.94434368
177Pancreatic cysts (HP:0001737)0.93333867
178Aqueductal stenosis (HP:0002410)0.92940522
179Overriding aorta (HP:0002623)0.92453252
180Epileptic encephalopathy (HP:0200134)0.91079450
181Specific learning disability (HP:0001328)0.90778413
182Abnormal gallbladder physiology (HP:0012438)0.88828766
183Cholecystitis (HP:0001082)0.88828766
184Abnormality of the diencephalon (HP:0010662)0.87968685
185Hemorrhage of the eye (HP:0011885)0.87716157
186Hand muscle atrophy (HP:0009130)0.87167201
187Midline defect of the nose (HP:0004122)0.83946178
188Depression (HP:0000716)0.83932478
189Abnormal number of incisors (HP:0011064)0.83101637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK14.71081354
2EPHA44.65264549
3MAP3K104.20801669
4IRAK23.66833063
5DYRK1B3.47264980
6PKN23.12472933
7CDK122.70530007
8TAF12.59810492
9STK162.36556457
10SGK4942.35383534
11SGK2232.35383534
12ICK2.33331634
13VRK22.13907655
14EPHB22.09000483
15BRSK22.02930369
16MAP2K71.94909593
17HIPK21.90606482
18TLK11.90471997
19BRD41.88959454
20ERBB21.88055455
21PINK11.76630192
22DYRK1A1.73283426
23AKT31.68943313
24WEE11.65264280
25SIK11.63926618
26NEK21.63331934
27PLK41.58104797
28TTK1.47881243
29CAMK1G1.47771422
30CDK91.45025263
31CAMK11.35043595
32NEK11.34801156
33KSR11.33278244
34CAMK1D1.28919947
35SMG11.27953604
36CDK191.27015291
37STK241.26222704
38GSK3A1.25375529
39SIK21.25329585
40PLK11.24453563
41MAP2K41.24056637
42CASK1.23022017
43NTRK21.21672526
44MAP3K61.18544649
45TRIB31.16394177
46PNCK1.16170742
47ADRBK11.08287740
48STK41.07917918
49BMX1.04895974
50DYRK31.04099723
51STK31.03069395
52PRKD31.01559065
53PIK3CA1.00735043
54BRSK10.99933751
55PAK60.97212224
56MAP3K40.95891477
57AURKA0.94727206
58AURKB0.94617103
59UHMK10.92986251
60ATR0.90781801
61WNK30.90518279
62RIPK10.89775012
63CDC70.87259741
64RET0.86946259
65SGK30.85629895
66FGFR10.83665960
67SCYL20.83582568
68PRKCH0.83307736
69VRK10.83008858
70BRAF0.82156186
71MAP3K90.81523895
72RPS6KB20.80600062
73LATS10.80448585
74CSNK1D0.79955989
75RPS6KA50.79311498
76CHUK0.78742267
77MARK10.77834285
78SGK20.77582082
79RPS6KA40.76564542
80MKNK10.76490157
81PRPF4B0.75779163
82MAPK90.74433288
83CSNK1A1L0.74156102
84CDK60.74119125
85MARK20.73439017
86BCR0.72155723
87ALK0.71721967
88ERBB30.69779657
89ZAK0.69774435
90TGFBR10.69748030
91PLK30.68795023
92PRKCG0.68196800
93NUAK10.67658396
94PLK20.66869382
95CDK10.65390855
96SGK10.64586057
97CSNK1G10.64437000
98STK110.63890103
99STK38L0.62300696
100PASK0.62120679
101FGFR20.62035864
102CSNK1G20.61722245
103TIE10.61418948
104MAPK70.61130721
105GSK3B0.60303926
106PRKD10.60035129
107PRKAA10.59990722
108MAPK140.59958409
109CSNK1G30.59324731
110RPS6KA30.57598132
111PRKCB0.56542789
112TYRO30.55084107
113BUB10.54881714
114MKNK20.52891336
115PTK60.52763720
116LRRK20.52729904
117WNK10.52627936
118MAPK120.52077479
119CDK20.52008373
120CDK30.51916657
121SRPK10.50100940
122BMPR1B0.49776883
123AKT20.48760658
124CSNK1E0.48044828
125CDK11A0.47574948
126CHEK20.45696503
127PRKCZ0.44455571
128CDK150.44189378
129CDK50.42892359
130CAMK40.42807254
131DAPK30.42736375
132PKN10.42545660
133PRKDC0.42096699
134CDC42BPA0.42011376
135CAMKK10.41910245
136MTOR0.41811426
137DYRK20.41344484
138ATM0.41287190
139MINK10.41122866
140CHEK10.41011275
141MAPK100.40730845
142AKT10.39362254
143EPHA20.39095101
144RPS6KA10.38580120
145CDK180.38576476
146CDK70.37282500
147CSNK2A20.36266459
148CDK140.34318392
149CDK40.33380820
150FGFR40.30806534
151NLK0.29913121

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.21620688
2DNA replication_Homo sapiens_hsa030303.53192027
3Mismatch repair_Homo sapiens_hsa034303.37090384
4Hedgehog signaling pathway_Homo sapiens_hsa043403.02795831
5Homologous recombination_Homo sapiens_hsa034402.63162922
6Fanconi anemia pathway_Homo sapiens_hsa034602.61319562
7Systemic lupus erythematosus_Homo sapiens_hsa053222.41064661
8Nucleotide excision repair_Homo sapiens_hsa034202.27815118
9Base excision repair_Homo sapiens_hsa034102.19214329
10Synaptic vesicle cycle_Homo sapiens_hsa047212.13637115
11Alcoholism_Homo sapiens_hsa050342.06306772
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02654442
13Phototransduction_Homo sapiens_hsa0474413.2589893
14Oxidative phosphorylation_Homo sapiens_hsa001901.76906040
15Parkinsons disease_Homo sapiens_hsa050121.73673818
16RNA degradation_Homo sapiens_hsa030181.71575150
17RNA transport_Homo sapiens_hsa030131.68692646
18Huntingtons disease_Homo sapiens_hsa050161.67378456
19Olfactory transduction_Homo sapiens_hsa047401.67094393
20Cell cycle_Homo sapiens_hsa041101.63845893
21GABAergic synapse_Homo sapiens_hsa047271.52912544
22RNA polymerase_Homo sapiens_hsa030201.48453351
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43987804
24Basal transcription factors_Homo sapiens_hsa030221.34780682
25p53 signaling pathway_Homo sapiens_hsa041151.23142747
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22121460
27mTOR signaling pathway_Homo sapiens_hsa041501.21917481
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.19336421
29Cholinergic synapse_Homo sapiens_hsa047251.15638738
30Pyrimidine metabolism_Homo sapiens_hsa002401.14964052
31Circadian entrainment_Homo sapiens_hsa047131.13211482
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06633081
33Protein export_Homo sapiens_hsa030601.05820611
34Notch signaling pathway_Homo sapiens_hsa043301.05609388
35Folate biosynthesis_Homo sapiens_hsa007901.05191619
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04149904
37Nitrogen metabolism_Homo sapiens_hsa009101.03783288
38Dopaminergic synapse_Homo sapiens_hsa047280.99452252
39Alzheimers disease_Homo sapiens_hsa050100.98013708
40Circadian rhythm_Homo sapiens_hsa047100.97341772
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.96735745
42Glutamatergic synapse_Homo sapiens_hsa047240.95979049
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.93737252
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93151060
45Non-homologous end-joining_Homo sapiens_hsa034500.91909313
46Non-small cell lung cancer_Homo sapiens_hsa052230.88878414
47Endometrial cancer_Homo sapiens_hsa052130.86720437
48Axon guidance_Homo sapiens_hsa043600.84460596
49Morphine addiction_Homo sapiens_hsa050320.84216578
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83965401
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83612422
52mRNA surveillance pathway_Homo sapiens_hsa030150.82913208
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82164724
54Renal cell carcinoma_Homo sapiens_hsa052110.81667769
55Retinol metabolism_Homo sapiens_hsa008300.81188409
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80739619
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80350994
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78059548
59Purine metabolism_Homo sapiens_hsa002300.77972905
60MicroRNAs in cancer_Homo sapiens_hsa052060.77346330
61HIF-1 signaling pathway_Homo sapiens_hsa040660.75316076
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74195513
63Lysine degradation_Homo sapiens_hsa003100.74121650
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72884204
65Colorectal cancer_Homo sapiens_hsa052100.72545032
66Biosynthesis of amino acids_Homo sapiens_hsa012300.71683259
67Chronic myeloid leukemia_Homo sapiens_hsa052200.69384919
68Glioma_Homo sapiens_hsa052140.68972831
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68388021
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68270683
71Hippo signaling pathway_Homo sapiens_hsa043900.67744850
72Vitamin B6 metabolism_Homo sapiens_hsa007500.64294315
73Steroid biosynthesis_Homo sapiens_hsa001000.63829577
74Viral carcinogenesis_Homo sapiens_hsa052030.62305914
75ECM-receptor interaction_Homo sapiens_hsa045120.60659943
76Insulin secretion_Homo sapiens_hsa049110.60279524
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59151049
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58959487
79Wnt signaling pathway_Homo sapiens_hsa043100.58239782
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56948599
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56376768
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54672344
83Bladder cancer_Homo sapiens_hsa052190.53072286
84Thyroid cancer_Homo sapiens_hsa052160.52495257
85Glucagon signaling pathway_Homo sapiens_hsa049220.52252695
86Serotonergic synapse_Homo sapiens_hsa047260.51247284
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49723081
88AMPK signaling pathway_Homo sapiens_hsa041520.49660286
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49470768
90TGF-beta signaling pathway_Homo sapiens_hsa043500.49342534
91Protein digestion and absorption_Homo sapiens_hsa049740.49182347
92Type II diabetes mellitus_Homo sapiens_hsa049300.48555363
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48534759
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48491956
95Oxytocin signaling pathway_Homo sapiens_hsa049210.48260405
96Bile secretion_Homo sapiens_hsa049760.47044277
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46719186
98Fructose and mannose metabolism_Homo sapiens_hsa000510.45657201
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45336675
100Tight junction_Homo sapiens_hsa045300.43322579
101Long-term potentiation_Homo sapiens_hsa047200.43226105
102HTLV-I infection_Homo sapiens_hsa051660.41934684
103One carbon pool by folate_Homo sapiens_hsa006700.40518564
104Cocaine addiction_Homo sapiens_hsa050300.40507333
105Proteoglycans in cancer_Homo sapiens_hsa052050.39946689
106Pancreatic cancer_Homo sapiens_hsa052120.39747056
107Inositol phosphate metabolism_Homo sapiens_hsa005620.39674572
108Melanoma_Homo sapiens_hsa052180.39645542
109Cardiac muscle contraction_Homo sapiens_hsa042600.39260879
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38805302
111Sulfur relay system_Homo sapiens_hsa041220.38444889
112ABC transporters_Homo sapiens_hsa020100.38410809
113Basal cell carcinoma_Homo sapiens_hsa052170.37924370
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.37452859
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37417618
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36687345
117Nicotine addiction_Homo sapiens_hsa050330.36628981
118Gastric acid secretion_Homo sapiens_hsa049710.35715250
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35481476
120VEGF signaling pathway_Homo sapiens_hsa043700.35315533
121Spliceosome_Homo sapiens_hsa030400.34743820
122cAMP signaling pathway_Homo sapiens_hsa040240.33896774
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33465206
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.31088823
125Fat digestion and absorption_Homo sapiens_hsa049750.30823691
126Small cell lung cancer_Homo sapiens_hsa052220.30435114
127Metabolic pathways_Homo sapiens_hsa011000.30203710
128Regulation of autophagy_Homo sapiens_hsa041400.29737472
129Rap1 signaling pathway_Homo sapiens_hsa040150.29699162
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29258587
131Fatty acid biosynthesis_Homo sapiens_hsa000610.29155238
132Vitamin digestion and absorption_Homo sapiens_hsa049770.28844041
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28634173
134Oocyte meiosis_Homo sapiens_hsa041140.28143312
135Carbon metabolism_Homo sapiens_hsa012000.27880764
136Insulin resistance_Homo sapiens_hsa049310.27217672
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27190612
138Ras signaling pathway_Homo sapiens_hsa040140.27088595
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26741445
140Linoleic acid metabolism_Homo sapiens_hsa005910.26500484
141FoxO signaling pathway_Homo sapiens_hsa040680.26045284
142Amphetamine addiction_Homo sapiens_hsa050310.25468322
143Prostate cancer_Homo sapiens_hsa052150.24978646
144Glycerolipid metabolism_Homo sapiens_hsa005610.24678814
145Pathways in cancer_Homo sapiens_hsa052000.24439216
146Melanogenesis_Homo sapiens_hsa049160.24276006
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24206264
148Arachidonic acid metabolism_Homo sapiens_hsa005900.23877667
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23831059
150Thyroid hormone synthesis_Homo sapiens_hsa049180.23235436
151Arginine and proline metabolism_Homo sapiens_hsa003300.23088262
152Selenocompound metabolism_Homo sapiens_hsa004500.23062920
153Pyruvate metabolism_Homo sapiens_hsa006200.22236727
154Dilated cardiomyopathy_Homo sapiens_hsa054140.22021021
1552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21841497
156MAPK signaling pathway_Homo sapiens_hsa040100.21383985
157alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21023732
158Fatty acid metabolism_Homo sapiens_hsa012120.20935855
159Adherens junction_Homo sapiens_hsa045200.20419933
160Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18585774
161PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17909757
162Glutathione metabolism_Homo sapiens_hsa004800.17797085

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »