ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.31340490
2	response to pheromone (GO:0019236)	4.24454058
3	detection of light stimulus involved in sensory perception (GO:0050962)	4.11084305
4	detection of light stimulus involved in visual perception (GO:0050908)	4.11084305
5	synapsis (GO:0007129)	3.97840177
6	DNA methylation involved in gamete generation (GO:0043046)	3.90667297
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.80762401
8	indole-containing compound catabolic process (GO:0042436)	3.78811136
9	indolalkylamine catabolic process (GO:0046218)	3.78811136
10	tryptophan catabolic process (GO:0006569)	3.78811136
11	kynurenine metabolic process (GO:0070189)	3.76212901
12	axoneme assembly (GO:0035082)	3.72778168
13	protein K11-linked deubiquitination (GO:0035871)	3.55521528
14	fucose catabolic process (GO:0019317)	3.42636627
15	L-fucose metabolic process (GO:0042354)	3.42636627
16	L-fucose catabolic process (GO:0042355)	3.42636627
17	retinal cone cell development (GO:0046549)	3.42495913
18	behavioral response to nicotine (GO:0035095)	3.38241676
19	indolalkylamine metabolic process (GO:0006586)	3.33446715
20	DNA double-strand break processing (GO:0000729)	3.26721479
21	cornea development in camera-type eye (GO:0061303)	3.24276610
22	reciprocal meiotic recombination (GO:0007131)	3.21638689
23	reciprocal DNA recombination (GO:0035825)	3.21638689
24	regulation of meiosis I (GO:0060631)	3.20765668
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.14746186
26	meiotic chromosome segregation (GO:0045132)	3.13904133
27	multicellular organism reproduction (GO:0032504)	3.11837628
28	tryptophan metabolic process (GO:0006568)	3.09667439
29	inner ear receptor stereocilium organization (GO:0060122)	3.08080756
30	male meiosis I (GO:0007141)	3.05194316
31	platelet dense granule organization (GO:0060155)	3.03268265
32	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.02220493
33	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97438235
34	cellular biogenic amine catabolic process (GO:0042402)	2.94755449
35	amine catabolic process (GO:0009310)	2.94755449
36	ketone body metabolic process (GO:1902224)	2.88090609
37	behavioral response to ethanol (GO:0048149)	2.87870486
38	DNA deamination (GO:0045006)	2.87695281
39	adaptation of signaling pathway (GO:0023058)	2.87538347
40	regulation of action potential (GO:0098900)	2.87454163
41	gamma-aminobutyric acid transport (GO:0015812)	2.87010881
42	cilium morphogenesis (GO:0060271)	2.84216732
43	nucleotide transmembrane transport (GO:1901679)	2.83526034
44	proline transport (GO:0015824)	2.81826852
45	epithelial cilium movement (GO:0003351)	2.81822531
46	protein complex biogenesis (GO:0070271)	2.81002244
47	tachykinin receptor signaling pathway (GO:0007217)	2.80597862
48	nonmotile primary cilium assembly (GO:0035058)	2.80393023
49	photoreceptor cell maintenance (GO:0045494)	2.79014261
50	regulation of acrosome reaction (GO:0060046)	2.78690311
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78650328
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78650328
53	NADH dehydrogenase complex assembly (GO:0010257)	2.78650328
54	cellular ketone body metabolic process (GO:0046950)	2.78624054
55	neural tube formation (GO:0001841)	2.76119337
56	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.76053942
57	regulation of cilium movement (GO:0003352)	2.75758863
58	protein polyglutamylation (GO:0018095)	2.75037162
59	auditory receptor cell stereocilium organization (GO:0060088)	2.73468220
60	regulation of glucokinase activity (GO:0033131)	2.72896388
61	regulation of hexokinase activity (GO:1903299)	2.72896388
62	positive regulation of meiosis (GO:0045836)	2.71549381
63	photoreceptor cell development (GO:0042461)	2.69729238
64	inositol phosphate catabolic process (GO:0071545)	2.69295698
65	respiratory chain complex IV assembly (GO:0008535)	2.68847709
66	water-soluble vitamin biosynthetic process (GO:0042364)	2.68139727
67	transepithelial transport (GO:0070633)	2.67766398
68	male meiosis (GO:0007140)	2.67674247
69	glycosphingolipid biosynthetic process (GO:0006688)	2.66348239
70	cilium organization (GO:0044782)	2.66250238
71	recombinational repair (GO:0000725)	2.57919183
72	cilium assembly (GO:0042384)	2.57884063
73	negative regulation of dendrite development (GO:2000171)	2.57845582
74	mannosylation (GO:0097502)	2.57740939
75	C-terminal protein amino acid modification (GO:0018410)	2.57225066
76	double-strand break repair via homologous recombination (GO:0000724)	2.56784725
77	positive regulation of meiotic cell cycle (GO:0051446)	2.55401104
78	eye photoreceptor cell development (GO:0042462)	2.54645988
79	indole-containing compound metabolic process (GO:0042430)	2.54089080
80	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53217032
81	dopamine transport (GO:0015872)	2.51813432
82	keratinocyte development (GO:0003334)	2.51628279
83	limb bud formation (GO:0060174)	2.49856449
84	kidney morphogenesis (GO:0060993)	2.48881390
85	mitochondrial respiratory chain complex assembly (GO:0033108)	2.48438260
86	benzene-containing compound metabolic process (GO:0042537)	2.48067871
87	protein localization to cilium (GO:0061512)	2.47713008
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47363563
89	* visual perception (GO:0007601)	2.46707580
90	* sensory perception of light stimulus (GO:0050953)	2.45322553
91	cilium movement (GO:0003341)	2.44665418
92	cytochrome complex assembly (GO:0017004)	2.43201347
93	reflex (GO:0060004)	2.41951882
94	negative regulation of mast cell activation (GO:0033004)	2.41713124
95	C-terminal protein lipidation (GO:0006501)	2.40569705
96	inositol phosphate dephosphorylation (GO:0046855)	2.39949964
97	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.39949964
98	regulation of collateral sprouting (GO:0048670)	2.39911812
99	rhodopsin mediated signaling pathway (GO:0016056)	2.39024504
100	polyol catabolic process (GO:0046174)	2.37928614

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62897125
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.04270846
3	VDR_22108803_ChIP-Seq_LS180_Human	2.99598450
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.83373923
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78401392
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67074755
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57247990
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.55010361
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.51380617
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24032970
11	EWS_26573619_Chip-Seq_HEK293_Human	2.23801949
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.19760456
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19614120
14	P300_19829295_ChIP-Seq_ESCs_Human	2.13633682
15	FUS_26573619_Chip-Seq_HEK293_Human	2.11950788
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04772407
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98643777
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.96695093
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92508859
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89369279
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87608719
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.84970521
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83368945
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.74697635
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.74570310
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72495548
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70612640
28	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68111470
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.64577319
30	AR_25329375_ChIP-Seq_VCAP_Human	1.62046635
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.60936281
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59281203
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.59281203
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.58848529
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57020267
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53971616
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53870312
38	TCF4_23295773_ChIP-Seq_U87_Human	1.52615832
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52023271
40	STAT3_23295773_ChIP-Seq_U87_Human	1.51003799
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50214360
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49108026
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49104560
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47236316
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.40293975
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39157304
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38837163
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38198643
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36882950
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35750688
51	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.35449952
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35061707
53	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.34563429
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34199995
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33773166
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31214186
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30768236
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30768236
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30695148
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30695148
61	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26543735
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25366895
63	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24822916
64	NCOR_22424771_ChIP-Seq_293T_Human	1.24614099
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23921771
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23263018
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.23196366
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22727946
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22727946
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22562518
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21526838
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20917531
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20331182
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20153633
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19646705
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18112678
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17480011
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.17137327
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16785955
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15514968
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14956424
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13691714
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12542901
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12135406
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11389703
86	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.10779554
87	AR_20517297_ChIP-Seq_VCAP_Human	1.10778043
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09688907
89	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09318920
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.08672109
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06009303
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05651091
93	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05258753
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04856745
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03348989
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02917997
97	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02673192
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02178911
99	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01042648
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00729251

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.47104662
2	MP0002102_abnormal_ear_morphology	2.90707690
3	MP0005551_abnormal_eye_electrophysiolog	2.90024612
4	MP0000372_irregular_coat_pigmentation	2.80120098
5	MP0003195_calcinosis	2.74875298
6	MP0001986_abnormal_taste_sensitivity	2.72478421
7	MP0003787_abnormal_imprinting	2.57019098
8	MP0001968_abnormal_touch/_nociception	2.38294503
9	MP0000569_abnormal_digit_pigmentation	2.26613560
10	MP0002837_dystrophic_cardiac_calcinosis	2.24101535
11	MP0002736_abnormal_nociception_after	2.23796339
12	MP0002938_white_spotting	2.15740229
13	MP0003880_abnormal_central_pattern	2.07335690
14	MP0003136_yellow_coat_color	2.03614501
15	MP0006292_abnormal_olfactory_placode	1.95497845
16	MP0005253_abnormal_eye_physiology	1.95007315
17	MP0005075_abnormal_melanosome_morpholog	1.91828714
18	MP0002638_abnormal_pupillary_reflex	1.90580816
19	MP0000427_abnormal_hair_cycle	1.89181249
20	MP0005174_abnormal_tail_pigmentation	1.84317775
21	MP0006072_abnormal_retinal_apoptosis	1.84119467
22	MP0004147_increased_porphyrin_level	1.80151413
23	MP0009745_abnormal_behavioral_response	1.77204997
24	MP0001984_abnormal_olfaction	1.72429996
25	MP0003011_delayed_dark_adaptation	1.71442053
26	MP0000631_abnormal_neuroendocrine_gland	1.69095997
27	MP0003646_muscle_fatigue	1.65564488
28	MP0009046_muscle_twitch	1.63576705
29	MP0003718_maternal_effect	1.62335900
30	MP0002876_abnormal_thyroid_physiology	1.61865631
31	MP0004885_abnormal_endolymph	1.61340549
32	MP0001501_abnormal_sleep_pattern	1.60228057
33	MP0002272_abnormal_nervous_system	1.60159296
34	MP0008872_abnormal_physiological_respon	1.56765293
35	MP0002234_abnormal_pharynx_morphology	1.56649704
36	MP0008875_abnormal_xenobiotic_pharmacok	1.52242079
37	MP0000015_abnormal_ear_pigmentation	1.45801101
38	MP0000013_abnormal_adipose_tissue	1.42771662
39	MP0005646_abnormal_pituitary_gland	1.39134190
40	MP0005379_endocrine/exocrine_gland_phen	1.37437623
41	MP0002163_abnormal_gland_morphology	1.35518927
42	MP0008058_abnormal_DNA_repair	1.33489234
43	MP0001485_abnormal_pinna_reflex	1.30578444
44	MP0002653_abnormal_ependyma_morphology	1.29322641
45	MP0002160_abnormal_reproductive_system	1.28251451
46	MP0003121_genomic_imprinting	1.28087833
47	MP0006276_abnormal_autonomic_nervous	1.22201748
48	MP0002751_abnormal_autonomic_nervous	1.19735290
49	MP0003786_premature_aging	1.19286147
50	MP0001502_abnormal_circadian_rhythm	1.19124828
51	MP0003137_abnormal_impulse_conducting	1.18517769
52	MP0001486_abnormal_startle_reflex	1.18235010
53	MP0002572_abnormal_emotion/affect_behav	1.17876162
54	MP0005423_abnormal_somatic_nervous	1.17551082
55	MP0005386_behavior/neurological_phenoty	1.16927377
56	MP0004924_abnormal_behavior	1.16927377
57	MP0005645_abnormal_hypothalamus_physiol	1.15939747
58	MP0008995_early_reproductive_senescence	1.15690312
59	MP0005171_absent_coat_pigmentation	1.14629116
60	MP0008789_abnormal_olfactory_epithelium	1.12732416
61	MP0004142_abnormal_muscle_tone	1.11395065
62	MP0000647_abnormal_sebaceous_gland	1.10688658
63	MP0001529_abnormal_vocalization	1.08475484
64	MP0002557_abnormal_social/conspecific_i	1.06800677
65	MP0004215_abnormal_myocardial_fiber	1.05761242
66	MP0005389_reproductive_system_phenotype	1.05448298
67	MP0006054_spinal_hemorrhage	1.05132273
68	MP0005195_abnormal_posterior_eye	1.05075329
69	MP0000383_abnormal_hair_follicle	1.02844161
70	MP0002067_abnormal_sensory_capabilities	1.02710573
71	MP0001929_abnormal_gametogenesis	1.02262354
72	MP0002095_abnormal_skin_pigmentation	1.02230581
73	MP0002064_seizures	1.01723530
74	MP0004043_abnormal_pH_regulation	1.00977367
75	MP0002229_neurodegeneration	1.00366540
76	MP0001970_abnormal_pain_threshold	1.00010221
77	MP0002734_abnormal_mechanical_nocicepti	0.99465951
78	MP0005410_abnormal_fertilization	0.97245480
79	MP0004742_abnormal_vestibular_system	0.96671114
80	MP0003698_abnormal_male_reproductive	0.96085524
81	MP0001324_abnormal_eye_pigmentation	0.95380149
82	MP0003635_abnormal_synaptic_transmissio	0.92172107
83	MP0001944_abnormal_pancreas_morphology	0.91715801
84	MP0002210_abnormal_sex_determination	0.91608473
85	MP0000778_abnormal_nervous_system	0.91310437
86	MP0002735_abnormal_chemical_nociception	0.89165595
87	MP0002733_abnormal_thermal_nociception	0.88757798
88	MP0002909_abnormal_adrenal_gland	0.86301572
89	MP0008057_abnormal_DNA_replication	0.85336195
90	MP0002277_abnormal_respiratory_mucosa	0.84964960
91	MP0004270_analgesia	0.84881734
92	MP0004133_heterotaxia	0.84372257
93	MP0002752_abnormal_somatic_nervous	0.84291855
94	MP0000613_abnormal_salivary_gland	0.83561213
95	MP0002063_abnormal_learning/memory/cond	0.83171017
96	MP0000653_abnormal_sex_gland	0.82768800
97	MP0002928_abnormal_bile_duct	0.82110637
98	MP0010386_abnormal_urinary_bladder	0.79169221
99	MP0001764_abnormal_homeostasis	0.79094065
100	MP0004085_abnormal_heartbeat	0.75068466

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.69077677
2	Congenital stationary night blindness (HP:0007642)	4.61616773
3	Cerebellar dysplasia (HP:0007033)	4.48488860
4	Pancreatic cysts (HP:0001737)	4.11195302
5	Pancreatic fibrosis (HP:0100732)	4.03053897
6	True hermaphroditism (HP:0010459)	3.79868872
7	Abnormality of midbrain morphology (HP:0002418)	3.66459562
8	Molar tooth sign on MRI (HP:0002419)	3.66459562
9	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.55094267
10	Nephronophthisis (HP:0000090)	3.46201783
11	Hyperventilation (HP:0002883)	3.39476487
12	Abnormality of the renal cortex (HP:0011035)	3.20232548
13	Medial flaring of the eyebrow (HP:0010747)	3.19497333
14	Abnormality of the renal medulla (HP:0100957)	3.18356477
15	Gaze-evoked nystagmus (HP:0000640)	3.05455205
16	Attenuation of retinal blood vessels (HP:0007843)	3.01229325
17	Retinal dysplasia (HP:0007973)	2.94044656
18	Hypoplasia of the pons (HP:0012110)	2.90825297
19	Stomach cancer (HP:0012126)	2.81413410
20	Retinal atrophy (HP:0001105)	2.74917980
21	Abnormality of the pons (HP:0007361)	2.70355708
22	Abolished electroretinogram (ERG) (HP:0000550)	2.68456125
23	Chronic hepatic failure (HP:0100626)	2.59487613
24	Lissencephaly (HP:0001339)	2.52416791
25	Tubular atrophy (HP:0000092)	2.50854948
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.48739959
27	Absent speech (HP:0001344)	2.46866089
28	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.46859374
29	Pendular nystagmus (HP:0012043)	2.46833225
30	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.46718205
31	Hypoplasia of the fovea (HP:0007750)	2.46718205
32	Gait imbalance (HP:0002141)	2.43330390
33	Colon cancer (HP:0003003)	2.42714002
34	Cystic liver disease (HP:0006706)	2.40762386
35	Congenital primary aphakia (HP:0007707)	2.37602100
36	Nephrogenic diabetes insipidus (HP:0009806)	2.33396768
37	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29270637
38	Optic nerve hypoplasia (HP:0000609)	2.27100587
39	Severe muscular hypotonia (HP:0006829)	2.23595847
40	Decreased central vision (HP:0007663)	2.23177318
41	Sclerocornea (HP:0000647)	2.20239012
42	Polydipsia (HP:0001959)	2.15555524
43	Abnormal drinking behavior (HP:0030082)	2.15555524
44	Bony spicule pigmentary retinopathy (HP:0007737)	2.13644846
45	Abnormality of the fovea (HP:0000493)	2.13069943
46	Congenital hepatic fibrosis (HP:0002612)	2.12643775
47	Renal cortical cysts (HP:0000803)	2.11461704
48	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.10578278
49	Congenital sensorineural hearing impairment (HP:0008527)	2.09853980
50	Neoplasm of the adrenal cortex (HP:0100641)	2.08828720
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07663089
52	Pachygyria (HP:0001302)	2.05534560
53	Intestinal atresia (HP:0011100)	2.03437121
54	Genital tract atresia (HP:0001827)	2.03310701
55	Broad-based gait (HP:0002136)	2.02131320
56	Furrowed tongue (HP:0000221)	2.00601366
57	Postaxial foot polydactyly (HP:0001830)	2.00349198
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98767206
59	Methylmalonic acidemia (HP:0002912)	1.98751727
60	Anencephaly (HP:0002323)	1.96954439
61	Polyuria (HP:0000103)	1.96019934
62	Increased CSF lactate (HP:0002490)	1.96010566
63	Progressive cerebellar ataxia (HP:0002073)	1.95442111
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94669735
65	Progressive inability to walk (HP:0002505)	1.91344113
66	Increased corneal curvature (HP:0100692)	1.91035748
67	Keratoconus (HP:0000563)	1.91035748
68	Progressive macrocephaly (HP:0004481)	1.89607597
69	Abnormality of alanine metabolism (HP:0010916)	1.88569547
70	Hyperalaninemia (HP:0003348)	1.88569547
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88569547
72	Vaginal atresia (HP:0000148)	1.87933894
73	Genetic anticipation (HP:0003743)	1.83840580
74	Small hand (HP:0200055)	1.83753516
75	Dandy-Walker malformation (HP:0001305)	1.81556899
76	Tubulointerstitial abnormality (HP:0001969)	1.80694225
77	Male pseudohermaphroditism (HP:0000037)	1.79863640
78	Febrile seizures (HP:0002373)	1.78427032
79	Constricted visual fields (HP:0001133)	1.78399749
80	Hemiparesis (HP:0001269)	1.77982526
81	Mitochondrial inheritance (HP:0001427)	1.77834969
82	Retinitis pigmentosa (HP:0000510)	1.77351269
83	Widely spaced teeth (HP:0000687)	1.76817023
84	Acute necrotizing encephalopathy (HP:0006965)	1.75246570
85	Tubulointerstitial fibrosis (HP:0005576)	1.74902505
86	Abnormal biliary tract physiology (HP:0012439)	1.74588878
87	Bile duct proliferation (HP:0001408)	1.74588878
88	Mesangial abnormality (HP:0001966)	1.73301288
89	Abnormality of the labia minora (HP:0012880)	1.73278194
90	Hypoalbuminemia (HP:0003073)	1.73081763
91	Abnormal albumin level (HP:0012116)	1.73081763
92	Albinism (HP:0001022)	1.72168452
93	Anterior segment dysgenesis (HP:0007700)	1.71805962
94	Thyroiditis (HP:0100646)	1.71650420
95	Postaxial hand polydactyly (HP:0001162)	1.69457608
96	Occipital encephalocele (HP:0002085)	1.69118303
97	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.67583775
98	Abnormality of macular pigmentation (HP:0008002)	1.65737212
99	Decreased circulating renin level (HP:0003351)	1.64972137
100	Optic disc pallor (HP:0000543)	1.64821218

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.80386785
2	MAP4K2	3.33558811
3	BMPR1B	2.76478229
4	ADRBK2	2.69707265
5	GRK1	2.66291730
6	WNK3	2.60115351
7	CASK	2.50623982
8	TAOK3	2.35428092
9	TNIK	2.28753474
10	PINK1	2.25996348
11	ZAK	2.17697544
12	MAPK13	2.09241497
13	NUAK1	2.08598888
14	ACVR1B	2.02765187
15	TRIM28	2.00144249
16	MARK3	1.77718372
17	STK39	1.69230567
18	STK38L	1.68413625
19	MAP3K4	1.67598290
20	MST4	1.53480480
21	WNK4	1.38418021
22	OXSR1	1.35983654
23	INSRR	1.28189431
24	PLK2	1.26469087
25	BCR	1.22960417
26	NLK	1.19697554
27	PDK2	1.18690548
28	MKNK2	1.17478588
29	PTK2B	1.15801704
30	DAPK2	1.13036883
31	MARK1	1.12680807
32	FGFR2	1.10052786
33	CSNK1G1	1.07702615
34	PAK3	1.04895204
35	ERBB3	1.04598690
36	NTRK3	1.02561636
37	CAMKK2	1.02013992
38	PHKG1	0.99403579
39	PHKG2	0.99403579
40	TLK1	0.98150791
41	EIF2AK3	0.97871100
42	PRKCE	0.97810875
43	STK10	0.93673339
44	BRSK2	0.92889786
45	CSNK1G3	0.90380253
46	CSNK1G2	0.89235947
47	STK11	0.87967209
48	DYRK2	0.85835010
49	PRKCI	0.84259689
50	EPHA4	0.83872868
51	ADRBK1	0.81477847
52	MAP2K7	0.78834003
53	PRKCG	0.76317300
54	AKT3	0.70925179
55	CSNK1A1L	0.70613062
56	STK16	0.67962386
57	MAP3K12	0.64796538
58	IKBKB	0.64419261
59	VRK1	0.64169609
60	MUSK	0.63723870
61	CSNK1D	0.63047711
62	TAF1	0.61050975
63	TNK2	0.60086418
64	PIM1	0.59226314
65	TXK	0.59133330
66	PIK3CA	0.58581574
67	TGFBR1	0.56038596
68	WEE1	0.55549019
69	CAMK2A	0.53650310
70	FER	0.53534194
71	PLK1	0.49312242
72	STK38	0.48875117
73	PKN1	0.48471492
74	PLK3	0.48009344
75	PRKAA2	0.47188055
76	CSNK1A1	0.46310957
77	MKNK1	0.45411490
78	PRKACA	0.44269353
79	PRKAA1	0.41585459
80	KSR1	0.41431350
81	NTRK2	0.41372218
82	CCNB1	0.38819641
83	BCKDK	0.38734399
84	GRK5	0.38538520
85	LMTK2	0.38240978
86	CHUK	0.37223655
87	ATM	0.36744538
88	TEC	0.36206883
89	IRAK1	0.34894415
90	PRKG1	0.34686856
91	SRPK1	0.33768517
92	RPS6KA5	0.30435501
93	PRKCZ	0.29384349
94	PLK4	0.29331128
95	ATR	0.29197768
96	VRK2	0.29099418
97	STK3	0.29064302
98	PRKACB	0.28909389
99	TIE1	0.27871348
100	PRKCA	0.27030201

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.40296964
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.92403114
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.81971409
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.70202097
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.38482003
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31328641
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.19233542
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12374302
9	Homologous recombination_Homo sapiens_hsa03440	2.11450860
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.10424935
11	Butanoate metabolism_Homo sapiens_hsa00650	2.07731940
12	Caffeine metabolism_Homo sapiens_hsa00232	1.97848596
13	Nicotine addiction_Homo sapiens_hsa05033	1.97076560
14	Protein export_Homo sapiens_hsa03060	1.96539408
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95463468
16	Basal transcription factors_Homo sapiens_hsa03022	1.93528500
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91623274
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88185190
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.87486828
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.78644217
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.73734273
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.68862693
23	Propanoate metabolism_Homo sapiens_hsa00640	1.61918092
24	Taste transduction_Homo sapiens_hsa04742	1.57845164
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.55729035
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55664797
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.46879045
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.43488530
29	Olfactory transduction_Homo sapiens_hsa04740	1.40949490
30	Insulin secretion_Homo sapiens_hsa04911	1.35156870
31	RNA polymerase_Homo sapiens_hsa03020	1.24582624
32	Circadian rhythm_Homo sapiens_hsa04710	1.23175322
33	Sulfur metabolism_Homo sapiens_hsa00920	1.19351456
34	Regulation of autophagy_Homo sapiens_hsa04140	1.18697911
35	RNA degradation_Homo sapiens_hsa03018	1.16560999
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14972935
37	Peroxisome_Homo sapiens_hsa04146	1.14439500
38	Retinol metabolism_Homo sapiens_hsa00830	1.10601723
39	Morphine addiction_Homo sapiens_hsa05032	1.10303531
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09726574
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.08961357
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07541913
43	Circadian entrainment_Homo sapiens_hsa04713	1.07089700
44	Parkinsons disease_Homo sapiens_hsa05012	1.06732573
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04699214
46	ABC transporters_Homo sapiens_hsa02010	1.04256046
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98168897
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97557551
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.96471156
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.94075562
51	GABAergic synapse_Homo sapiens_hsa04727	0.92405274
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92092420
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92084107
54	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90215683
55	Salivary secretion_Homo sapiens_hsa04970	0.88471608
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85036996
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83078887
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79606259
59	Serotonergic synapse_Homo sapiens_hsa04726	0.76666246
60	Amphetamine addiction_Homo sapiens_hsa05031	0.76065771
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.75762339
62	Cocaine addiction_Homo sapiens_hsa05030	0.73216405
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72397584
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.72281515
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.70641407
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69816568
67	Huntingtons disease_Homo sapiens_hsa05016	0.68549283
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.65541303
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65530291
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64353706
71	Metabolic pathways_Homo sapiens_hsa01100	0.63460141
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61191106
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59054261
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58606790
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54178978
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52354158
77	Purine metabolism_Homo sapiens_hsa00230	0.49594141
78	Proteasome_Homo sapiens_hsa03050	0.46025405
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45184540
80	Mineral absorption_Homo sapiens_hsa04978	0.45132378
81	Fatty acid degradation_Homo sapiens_hsa00071	0.44982863
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44586791
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43802361
84	Alzheimers disease_Homo sapiens_hsa05010	0.43567788
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43435374
86	Lysine degradation_Homo sapiens_hsa00310	0.43420885
87	One carbon pool by folate_Homo sapiens_hsa00670	0.43409157
88	Glutathione metabolism_Homo sapiens_hsa00480	0.42863183
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42790578
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42273104
91	Fatty acid elongation_Homo sapiens_hsa00062	0.42064010
92	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41431780
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40039113
94	Histidine metabolism_Homo sapiens_hsa00340	0.38834934
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37644634
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37188593
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.36478461
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35179301
99	RNA transport_Homo sapiens_hsa03013	0.31951320
100	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.31052666

RAX2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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