RB1CC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.08339008
2fusion of sperm to egg plasma membrane (GO:0007342)7.47532367
3axonemal dynein complex assembly (GO:0070286)7.37995001
4acrosome assembly (GO:0001675)7.29433449
5sperm motility (GO:0030317)6.84113223
6multicellular organism reproduction (GO:0032504)6.58492810
7male meiosis (GO:0007140)6.56498941
8epithelial cilium movement (GO:0003351)6.42676236
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.25549917
10synaptonemal complex organization (GO:0070193)6.20728233
11synaptonemal complex assembly (GO:0007130)5.92147644
12cilium movement (GO:0003341)5.89440647
13plasma membrane fusion (GO:0045026)5.87985397
14monoubiquitinated protein deubiquitination (GO:0035520)5.77583861
15male meiosis I (GO:0007141)5.52526562
16spermatid development (GO:0007286)5.43170759
17acrosome reaction (GO:0007340)5.40660335
18sperm-egg recognition (GO:0035036)5.35197016
19motile cilium assembly (GO:0044458)5.29900008
20negative regulation of inclusion body assembly (GO:0090084)5.13750219
21reproduction (GO:0000003)5.05892532
22DNA methylation involved in gamete generation (GO:0043046)5.02290087
23cell-cell recognition (GO:0009988)4.76031884
24binding of sperm to zona pellucida (GO:0007339)4.66848160
25meiosis I (GO:0007127)4.52584236
26regulation of meiosis I (GO:0060631)4.28510782
27regulation of cilium movement (GO:0003352)4.27967129
28microtubule depolymerization (GO:0007019)4.22013077
29single fertilization (GO:0007338)4.21217907
30seminiferous tubule development (GO:0072520)4.10682638
31cell wall macromolecule catabolic process (GO:0016998)4.02345827
32cell wall macromolecule metabolic process (GO:0044036)4.02345827
33chromosome organization involved in meiosis (GO:0070192)3.97339403
34meiotic nuclear division (GO:0007126)3.89928980
35meiotic cell cycle (GO:0051321)3.89291837
36fertilization (GO:0009566)3.74189943
37ventricular system development (GO:0021591)3.71680995
38regulation of establishment of cell polarity (GO:2000114)3.70077375
39calcium ion-dependent exocytosis (GO:0017156)3.54520676
40mitotic sister chromatid cohesion (GO:0007064)3.52015973
41negative regulation of dendrite morphogenesis (GO:0050774)3.51758956
42microtubule severing (GO:0051013)3.50786622
43spermatogenesis (GO:0007283)3.50121871
44male gamete generation (GO:0048232)3.48757483
45cytoplasmic mRNA processing body assembly (GO:0033962)3.43906585
46cellular process involved in reproduction in multicellular organism (GO:0022412)3.43087504
47vitamin transmembrane transport (GO:0035461)3.41640878
48genitalia morphogenesis (GO:0035112)3.41245777
49protein targeting to Golgi (GO:0000042)3.41172690
50regulation of protein polyubiquitination (GO:1902914)3.39493268
51sperm capacitation (GO:0048240)3.37935081
52protein localization to cilium (GO:0061512)3.35462224
53peptidyl-threonine dephosphorylation (GO:0035970)3.34714167
54neural tube formation (GO:0001841)3.32222415
55gamete generation (GO:0007276)3.29759317
56germ cell development (GO:0007281)3.28530732
57negative regulation of dendrite development (GO:2000171)3.27133212
58pyrimidine nucleobase catabolic process (GO:0006208)3.21940060
59synaptic vesicle maturation (GO:0016188)3.20629561
60regulation of dendritic spine morphogenesis (GO:0061001)3.17980526
61cerebellar Purkinje cell differentiation (GO:0021702)3.17002220
62establishment of protein localization to Golgi (GO:0072600)3.16921275
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.10936424
64regulation of inclusion body assembly (GO:0090083)3.10009949
65polyol catabolic process (GO:0046174)3.08869127
66nuclear pore complex assembly (GO:0051292)3.02951618
67sister chromatid cohesion (GO:0007062)3.01111523
68retrograde transport, vesicle recycling within Golgi (GO:0000301)3.01010877
69cellular response to gamma radiation (GO:0071480)3.00849122
70gene silencing by RNA (GO:0031047)2.98714651
71regulation of synaptic vesicle exocytosis (GO:2000300)2.97449433
72neuron recognition (GO:0008038)2.96761982
73left/right pattern formation (GO:0060972)2.94069502
74microtubule-based movement (GO:0007018)2.92598244
75regulation of cAMP-dependent protein kinase activity (GO:2000479)2.92529055
76glutamate secretion (GO:0014047)2.90618175
77presynaptic membrane assembly (GO:0097105)2.86248804
78cell recognition (GO:0008037)2.86213288
79regulation of RNA export from nucleus (GO:0046831)2.85939274
80phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.85312914
81regulation of establishment or maintenance of cell polarity (GO:0032878)2.84773245
82meiotic cell cycle process (GO:1903046)2.84123729
83histone H3-K4 trimethylation (GO:0080182)2.80933603
84presynaptic membrane organization (GO:0097090)2.78390912
85interkinetic nuclear migration (GO:0022027)2.77849455
86neurotransmitter-gated ion channel clustering (GO:0072578)2.77835848
87peptidyl-lysine trimethylation (GO:0018023)2.77654237
88NLS-bearing protein import into nucleus (GO:0006607)2.77482873
89vocalization behavior (GO:0071625)2.76446644
90central nervous system projection neuron axonogenesis (GO:0021952)2.75372038
91regulation of cell communication by electrical coupling (GO:0010649)2.74099529
92centrosome localization (GO:0051642)2.73578807
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73417661
94negative regulation of translation, ncRNA-mediated (GO:0040033)2.73417661
95regulation of translation, ncRNA-mediated (GO:0045974)2.73417661
96axonal fasciculation (GO:0007413)2.72090435
97intraciliary transport (GO:0042073)2.71165056
98axoneme assembly (GO:0035082)2.69371346
99pore complex assembly (GO:0046931)2.69155671
100regulation of dendritic spine development (GO:0060998)2.68190660
101histone H3-K9 demethylation (GO:0033169)2.67737716
102nucleobase catabolic process (GO:0046113)2.67394224
103dendrite morphogenesis (GO:0048813)2.67123397
104microtubule anchoring (GO:0034453)2.66286762
105regulation of centriole replication (GO:0046599)2.66213112
106establishment of mitochondrion localization (GO:0051654)2.65043328
107cerebral cortex radially oriented cell migration (GO:0021799)2.64637246
108regulation of synaptic vesicle transport (GO:1902803)2.64046297
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63123874
110multicellular organismal reproductive process (GO:0048609)2.62074118
111positive regulation of mRNA 3-end processing (GO:0031442)2.56501107
112protein K11-linked deubiquitination (GO:0035871)2.56246119
113positive regulation of meiotic cell cycle (GO:0051446)2.54742641
114retinal cone cell development (GO:0046549)2.52859671
115regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52000162
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.51377602
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.51377602
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.51377602
119olfactory bulb development (GO:0021772)2.49417503
120synaptic vesicle docking involved in exocytosis (GO:0016081)2.47925232
121cilium organization (GO:0044782)2.47289690
122regulation of nucleobase-containing compound transport (GO:0032239)2.47145548
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.46670700
124mitochondrion transport along microtubule (GO:0047497)2.46670700
125neuronal action potential propagation (GO:0019227)2.46536723
126nucleus localization (GO:0051647)2.44863652
127ionotropic glutamate receptor signaling pathway (GO:0035235)2.44099844
128positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.42297186
129regulation of mRNA 3-end processing (GO:0031440)2.42055777
130regulation of clathrin-mediated endocytosis (GO:2000369)2.41842915
131positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41782670
132glutamate receptor signaling pathway (GO:0007215)2.41694987
133protein K48-linked deubiquitination (GO:0071108)2.41328529
134early endosome to late endosome transport (GO:0045022)2.41303246
135positive regulation of mRNA processing (GO:0050685)2.40789505
136nuclear pore organization (GO:0006999)2.40783000
137protein localization to synapse (GO:0035418)2.40201150
138eye photoreceptor cell differentiation (GO:0001754)2.40181501
139photoreceptor cell differentiation (GO:0046530)2.40181501
140limb bud formation (GO:0060174)2.39907937
141regulation of microtubule-based movement (GO:0060632)2.39021862
142cilium assembly (GO:0042384)2.38776800
143negative regulation of DNA recombination (GO:0045910)2.38004092
144regulation of DNA endoreduplication (GO:0032875)2.37794658
145histone H3-K9 methylation (GO:0051567)2.37666989
146vesicle transport along microtubule (GO:0047496)2.36933121
147neurotransmitter catabolic process (GO:0042135)2.36428704
148positive regulation of microtubule polymerization (GO:0031116)2.33783154
149retina layer formation (GO:0010842)2.33413277
150positive regulation of meiosis (GO:0045836)2.33058883
151cellular component assembly involved in morphogenesis (GO:0010927)2.32999480
152establishment of nucleus localization (GO:0040023)2.31949977
153central nervous system neuron axonogenesis (GO:0021955)2.31685217
154keratinocyte development (GO:0003334)2.31089966
155regulation of protein glycosylation (GO:0060049)2.31037322
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30840891
157neuron cell-cell adhesion (GO:0007158)2.29608699
158mechanosensory behavior (GO:0007638)2.29519482
159positive regulation of macroautophagy (GO:0016239)2.28440232
160protein localization to Golgi apparatus (GO:0034067)2.28326667
161calcium ion import (GO:0070509)2.27902584
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.27404084
163chemosensory behavior (GO:0007635)2.26967673
164regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.26912190
165positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.26912190
166regulation of telomere maintenance (GO:0032204)2.26581869
167synaptic vesicle exocytosis (GO:0016079)2.26268929
168organelle transport along microtubule (GO:0072384)2.25623999
169negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.24734049
170regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.23768252
171exploration behavior (GO:0035640)2.22696993
172neurofilament cytoskeleton organization (GO:0060052)2.22137955
173clathrin coat assembly (GO:0048268)2.22063194
174regulation of Rac protein signal transduction (GO:0035020)2.21778155
175protein K63-linked deubiquitination (GO:0070536)2.21712794
176positive regulation of protein autophosphorylation (GO:0031954)2.21625482
177negative regulation of neurotransmitter secretion (GO:0046929)2.21179053
178negative regulation of DNA-dependent DNA replication (GO:2000104)2.20657877
179positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.20022163
180cilium or flagellum-dependent cell motility (GO:0001539)11.3236726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59824929
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.98224100
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.89349769
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.25732262
5* FLI1_27457419_Chip-Seq_LIVER_Mouse2.73175265
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66090345
7GBX2_23144817_ChIP-Seq_PC3_Human2.42430946
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39053403
9* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32314140
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31974488
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25030681
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24404490
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.16658937
14TAF15_26573619_Chip-Seq_HEK293_Human2.13656626
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09739523
16ZNF274_21170338_ChIP-Seq_K562_Hela2.03372029
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.01479845
18* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94281143
19* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85811441
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83448812
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81494246
22SMAD4_21799915_ChIP-Seq_A2780_Human1.80364721
23* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77350428
24* NANOG_18555785_Chip-Seq_ESCs_Mouse1.76651254
25FUS_26573619_Chip-Seq_HEK293_Human1.75291296
26* NFE2_27457419_Chip-Seq_LIVER_Mouse1.74088855
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63957900
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63106808
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63014633
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60715104
31ER_23166858_ChIP-Seq_MCF-7_Human1.56997836
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.56006357
33* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54615235
34STAT3_23295773_ChIP-Seq_U87_Human1.53722634
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53503065
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53433327
37VDR_22108803_ChIP-Seq_LS180_Human1.52207102
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.50066310
39* EZH2_27294783_Chip-Seq_NPCs_Mouse1.48670054
40BCAT_22108803_ChIP-Seq_LS180_Human1.47514494
41AR_21572438_ChIP-Seq_LNCaP_Human1.46985258
42TCF4_23295773_ChIP-Seq_U87_Human1.45386070
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.44341038
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43712247
45* P300_19829295_ChIP-Seq_ESCs_Human1.43710095
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43406588
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43406588
48* E2F1_18555785_Chip-Seq_ESCs_Mouse1.41699561
49* P53_22387025_ChIP-Seq_ESCs_Mouse1.40913201
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37544839
51AR_25329375_ChIP-Seq_VCAP_Human1.36225725
52REST_21632747_ChIP-Seq_MESCs_Mouse1.35928982
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35308368
54TP53_16413492_ChIP-PET_HCT116_Human1.34256927
55* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34077245
56* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34000668
57* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33957360
58* CMYC_18555785_Chip-Seq_ESCs_Mouse1.33953160
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.33433220
60* RNF2_27304074_Chip-Seq_NSC_Mouse1.33418857
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32506691
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31445718
63IGF1R_20145208_ChIP-Seq_DFB_Human1.30167460
64TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29740226
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29667335
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29437603
67CBP_20019798_ChIP-Seq_JUKART_Human1.27489690
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27489690
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26887894
70* OCT4_18555785_Chip-Seq_ESCs_Mouse1.26496581
71* KDM2B_26808549_Chip-Seq_REH_Human1.25091913
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24717594
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.24708551
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24196580
75* P300_18555785_Chip-Seq_ESCs_Mouse1.23902436
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.23885745
77* STAT3_18555785_Chip-Seq_ESCs_Mouse1.23568428
78* SOX2_18555785_Chip-Seq_ESCs_Mouse1.23536799
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22206640
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21966046
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21615973
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.21496519
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20967519
84* CRX_20693478_ChIP-Seq_RETINA_Mouse1.20602707
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20483465
86* NMYC_18555785_Chip-Seq_ESCs_Mouse1.20105483
87* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19248684
88SOX9_26525672_Chip-Seq_HEART_Mouse1.18270541
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.16467579
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.16222703
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15742264
92TBL1_22424771_ChIP-Seq_293T_Human1.15674355
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15249514
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15249514
95KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15240609
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15056201
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14261522
98* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13386463
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11676375
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11574274
101AHR_22903824_ChIP-Seq_MCF-7_Human1.11553082
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11192801
103RUNX2_22187159_ChIP-Seq_PCA_Human1.10953070
104* KLF4_18555785_Chip-Seq_ESCs_Mouse1.10491264
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10052775
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09586273
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09128528
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.08649066
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08211797
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07951155
111EWS_26573619_Chip-Seq_HEK293_Human1.06772817
112* PU1_27457419_Chip-Seq_LIVER_Mouse1.06735002
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06535431
114JUN_21703547_ChIP-Seq_K562_Human1.04968174
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04877861
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04649249
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.04429811
118CDX2_22108803_ChIP-Seq_LS180_Human1.04093093
119TCF4_18268006_ChIP-ChIP_LS174T_Human1.03698792
120* ZFX_18555785_Chip-Seq_ESCs_Mouse1.03470920
121* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03417579
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03379321
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03128808
124TCF4_22108803_ChIP-Seq_LS180_Human1.02909445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.93180857
2MP0008877_abnormal_DNA_methylation5.00600761
3MP0003698_abnormal_male_reproductive3.70711215
4MP0001929_abnormal_gametogenesis3.51229468
5MP0009046_muscle_twitch2.73314357
6MP0002009_preneoplasia2.69210753
7MP0003890_abnormal_embryonic-extraembry2.59592722
8MP0002210_abnormal_sex_determination2.55480692
9MP0000569_abnormal_digit_pigmentation2.54605861
10MP0003121_genomic_imprinting2.54095826
11MP0004859_abnormal_synaptic_plasticity2.52610384
12MP0005423_abnormal_somatic_nervous2.42728939
13MP0004270_analgesia2.38618896
14MP0008057_abnormal_DNA_replication2.21911616
15MP0003880_abnormal_central_pattern2.19551581
16MP0002161_abnormal_fertility/fecundity2.06072598
17MP0001145_abnormal_male_reproductive2.03367897
18MP0003635_abnormal_synaptic_transmissio1.99884221
19MP0000653_abnormal_sex_gland1.98913169
20MP0001440_abnormal_grooming_behavior1.88906722
21MP0003787_abnormal_imprinting1.86728404
22MP0005623_abnormal_meninges_morphology1.80281264
23MP0003122_maternal_imprinting1.78101185
24MP0001501_abnormal_sleep_pattern1.74336518
25MP0000427_abnormal_hair_cycle1.72144699
26MP0001529_abnormal_vocalization1.67086037
27MP0001486_abnormal_startle_reflex1.59317402
28MP0010352_gastrointestinal_tract_polyps1.56833345
29MP0004145_abnormal_muscle_electrophysio1.55319795
30MP0001661_extended_life_span1.55084890
31MP0002063_abnormal_learning/memory/cond1.53561446
32MP0009745_abnormal_behavioral_response1.53459601
33MP0001299_abnormal_eye_distance/1.51694697
34MP0002734_abnormal_mechanical_nocicepti1.50903429
35MP0001984_abnormal_olfaction1.50044167
36MP0002160_abnormal_reproductive_system1.49809595
37MP0003123_paternal_imprinting1.47005841
38MP0000383_abnormal_hair_follicle1.46251531
39MP0002102_abnormal_ear_morphology1.41759720
40MP0003879_abnormal_hair_cell1.35212549
41MP0002572_abnormal_emotion/affect_behav1.32350143
42MP0010234_abnormal_vibrissa_follicle1.31772067
43MP0001968_abnormal_touch/_nociception1.30859360
44MP0000955_abnormal_spinal_cord1.28848026
45MP0005647_abnormal_sex_gland1.28557506
46MP0003567_abnormal_fetal_cardiomyocyte1.28502465
47MP0003656_abnormal_erythrocyte_physiolo1.26237493
48MP0009780_abnormal_chondrocyte_physiolo1.25372275
49MP0010678_abnormal_skin_adnexa1.24728917
50MP0002272_abnormal_nervous_system1.23329023
51MP0004147_increased_porphyrin_level1.21839494
52MP0006276_abnormal_autonomic_nervous1.19480804
53MP0009697_abnormal_copulation1.18448827
54MP0002064_seizures1.18341824
55MP0000778_abnormal_nervous_system1.16597192
56MP0002067_abnormal_sensory_capabilities1.16306656
57MP0001485_abnormal_pinna_reflex1.16023154
58MP0010386_abnormal_urinary_bladder1.12018040
59MP0000647_abnormal_sebaceous_gland1.10795894
60MP0005187_abnormal_penis_morphology1.09090219
61MP0003861_abnormal_nervous_system1.08854923
62MP0001188_hyperpigmentation1.08640801
63MP0003718_maternal_effect1.07547853
64MP0003221_abnormal_cardiomyocyte_apopto1.06898140
65MP0002876_abnormal_thyroid_physiology1.05716767
66MP0002735_abnormal_chemical_nociception1.04442065
67MP0002234_abnormal_pharynx_morphology1.02839548
68MP0003633_abnormal_nervous_system1.01957444
69MP0003045_fibrosis1.01662617
70MP0004885_abnormal_endolymph1.01527489
71MP0004484_altered_response_of1.01436418
72MP0008995_early_reproductive_senescence1.00847789
73MP0002184_abnormal_innervation1.00757300
74MP0009703_decreased_birth_body1.00151605
75MP0010307_abnormal_tumor_latency1.00140501
76MP0000579_abnormal_nail_morphology0.99172092
77MP0003385_abnormal_body_wall0.98484683
78MP0004084_abnormal_cardiac_muscle0.94494604
79MP0005389_reproductive_system_phenotype0.94487803
80MP0002877_abnormal_melanocyte_morpholog0.90369737
81MP0004742_abnormal_vestibular_system0.89650176
82MP0008260_abnormal_autophagy0.89180566
83MP0005551_abnormal_eye_electrophysiolog0.89064078
84MP0001502_abnormal_circadian_rhythm0.88941735
85MP0003937_abnormal_limbs/digits/tail_de0.86552966
86MP0005253_abnormal_eye_physiology0.85159564
87MP0006292_abnormal_olfactory_placode0.84821971
88MP0002233_abnormal_nose_morphology0.83736378
89MP0001177_atelectasis0.83281904
90MP0003631_nervous_system_phenotype0.82062879
91MP0002736_abnormal_nociception_after0.79469763
92MP0002163_abnormal_gland_morphology0.79093124
93MP0003935_abnormal_craniofacial_develop0.79067530
94MP0003699_abnormal_female_reproductive0.78083301
95MP0004215_abnormal_myocardial_fiber0.76848703
96MP0003755_abnormal_palate_morphology0.75315931
97MP0002557_abnormal_social/conspecific_i0.74689056
98MP0003786_premature_aging0.74657752
99MP0002084_abnormal_developmental_patter0.73733819
100MP0004085_abnormal_heartbeat0.73118103
101MP0002653_abnormal_ependyma_morphology0.72947110
102MP0002752_abnormal_somatic_nervous0.72944782
103MP0008058_abnormal_DNA_repair0.72819211
104MP0003119_abnormal_digestive_system0.72673043
105MP0001346_abnormal_lacrimal_gland0.72548969
106MP0002229_neurodegeneration0.72249916
107MP0005394_taste/olfaction_phenotype0.71976222
108MP0005499_abnormal_olfactory_system0.71976222
109MP0001765_abnormal_ion_homeostasis0.70526977
110MP0009384_cardiac_valve_regurgitation0.70194693
111MP0002081_perinatal_lethality0.69657614
112MP0005646_abnormal_pituitary_gland0.69614368
113MP0006072_abnormal_retinal_apoptosis0.69044340
114MP0003868_abnormal_feces_composition0.64114352
115MP0001286_abnormal_eye_development0.63917402
116MP0000631_abnormal_neuroendocrine_gland0.63850371
117MP0002822_catalepsy0.63384418
118MP0005379_endocrine/exocrine_gland_phen0.62115837
119MP0005451_abnormal_body_composition0.62054875
120MP0008569_lethality_at_weaning0.61434859
121MP0002882_abnormal_neuron_morphology0.61314891
122MP0003941_abnormal_skin_development0.61192148
123MP0002837_dystrophic_cardiac_calcinosis0.61003183
124MP0004036_abnormal_muscle_relaxation0.60797368
125MP0001970_abnormal_pain_threshold0.60765100
126MP0002751_abnormal_autonomic_nervous0.59781451
127MP0002733_abnormal_thermal_nociception0.59667527
128MP0005395_other_phenotype0.59173184
129MP0003646_muscle_fatigue0.59104757
130MP0003950_abnormal_plasma_membrane0.57709072
131MP0001119_abnormal_female_reproductive0.56654502
132MP0002066_abnormal_motor_capabilities/c0.56568972
133MP0009250_abnormal_appendicular_skeleto0.56451738
134MP0004924_abnormal_behavior0.56267770
135MP0005386_behavior/neurological_phenoty0.56267770
136MP0002152_abnormal_brain_morphology0.56066360
137MP0002177_abnormal_outer_ear0.55903240
138MP0008007_abnormal_cellular_replicative0.55667609
139MP0004811_abnormal_neuron_physiology0.55635516
140MP0010094_abnormal_chromosome_stability0.53641363

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)8.79963667
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.79963667
3Abnormal respiratory motile cilium physiology (HP:0012261)7.02386989
4Abnormal respiratory epithelium morphology (HP:0012253)6.16952220
5Abnormal respiratory motile cilium morphology (HP:0005938)6.16952220
6Rhinitis (HP:0012384)5.89487491
7Abnormal ciliary motility (HP:0012262)5.80914674
8Chronic bronchitis (HP:0004469)4.93669936
9Infertility (HP:0000789)4.64459637
10Nephronophthisis (HP:0000090)3.48230988
11Focal motor seizures (HP:0011153)3.47163830
12Oligodactyly (hands) (HP:0001180)3.18410476
13Impaired vibration sensation in the lower limbs (HP:0002166)3.17518622
14Abnormality of the lower motor neuron (HP:0002366)3.16356502
15Bronchiectasis (HP:0002110)3.15478805
16Abnormality of the renal medulla (HP:0100957)3.01006104
17Impulsivity (HP:0100710)2.97706360
18Hepatoblastoma (HP:0002884)2.95465251
19Degeneration of the lateral corticospinal tracts (HP:0002314)2.95160020
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95160020
21Tubulointerstitial nephritis (HP:0001970)2.94085704
22Abnormality of the corticospinal tract (HP:0002492)2.89347123
23Hyperventilation (HP:0002883)2.88293267
24Protruding tongue (HP:0010808)2.87855198
25Microglossia (HP:0000171)2.78422947
26Nasal polyposis (HP:0100582)2.78309568
27Amyotrophic lateral sclerosis (HP:0007354)2.66564757
28Male infertility (HP:0003251)2.66340398
29Urinary urgency (HP:0000012)2.63962658
30Neoplasm of the oral cavity (HP:0100649)2.57478958
31Gaze-evoked nystagmus (HP:0000640)2.56044951
32Abnormality of midbrain morphology (HP:0002418)2.52786460
33Molar tooth sign on MRI (HP:0002419)2.52786460
34Action tremor (HP:0002345)2.52454470
35Gonadotropin excess (HP:0000837)2.49898034
36Bronchitis (HP:0012387)2.48067489
37Absent frontal sinuses (HP:0002688)2.44454706
38Fibular hypoplasia (HP:0003038)2.43820904
39Abnormal spermatogenesis (HP:0008669)2.43244220
40Pancreatic fibrosis (HP:0100732)2.40268910
41Papillary thyroid carcinoma (HP:0002895)2.39457233
42Azoospermia (HP:0000027)2.35134484
43Medulloblastoma (HP:0002885)2.30780297
44Inappropriate behavior (HP:0000719)2.30336033
45Curly hair (HP:0002212)2.29164188
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.29120700
47Progressive cerebellar ataxia (HP:0002073)2.27138908
48Focal seizures (HP:0007359)2.26927611
49Exotropia (HP:0000577)2.25658016
50Intestinal atresia (HP:0011100)2.24024476
51Febrile seizures (HP:0002373)2.21964125
52Abnormality of the labia minora (HP:0012880)2.17108708
53Genetic anticipation (HP:0003743)2.16771732
54Impaired social interactions (HP:0000735)2.16147380
55Abnormal social behavior (HP:0012433)2.16147380
56Abnormality of the astrocytes (HP:0100707)2.16081236
57Astrocytoma (HP:0009592)2.16081236
58Impaired vibratory sensation (HP:0002495)2.15915693
59Lower limb muscle weakness (HP:0007340)2.14111661
60Glucose intolerance (HP:0000833)2.13264746
61Glioma (HP:0009733)2.12932279
62Spastic gait (HP:0002064)2.10790029
63Cystic hygroma (HP:0000476)2.10385189
64Poor eye contact (HP:0000817)2.09673488
65Fair hair (HP:0002286)2.09581054
66Medial flaring of the eyebrow (HP:0010747)2.09298334
67Pancreatic islet-cell hyperplasia (HP:0004510)2.09132054
68Aqueductal stenosis (HP:0002410)2.07733481
69Tubulointerstitial abnormality (HP:0001969)2.06992781
70Dysdiadochokinesis (HP:0002075)2.06595487
71Drooling (HP:0002307)2.06253222
72Excessive salivation (HP:0003781)2.06253222
73Atonic seizures (HP:0010819)2.03935948
74Limb dystonia (HP:0002451)2.02856091
75Recurrent otitis media (HP:0000403)2.01220112
76Abnormality of the nasal mucosa (HP:0000433)2.01073585
77Generalized tonic-clonic seizures (HP:0002069)2.00656261
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1904239
79Dialeptic seizures (HP:0011146)1.99895735
80Abnormality of the ischium (HP:0003174)1.99637125
81Recurrent sinusitis (HP:0011108)1.97968216
82Rhabdomyosarcoma (HP:0002859)1.97025197
83Volvulus (HP:0002580)1.96637140
84Prostate neoplasm (HP:0100787)1.96351562
85Short nail (HP:0001799)1.95966564
86Congenital malformation of the right heart (HP:0011723)1.95568011
87Double outlet right ventricle (HP:0001719)1.95568011
88Oligodactyly (HP:0012165)1.93987746
89Cupped ear (HP:0000378)1.93649130
90Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93400311
91Abnormal hair whorl (HP:0010721)1.92575380
92Long clavicles (HP:0000890)1.90542244
93Abnormality of the renal cortex (HP:0011035)1.90489126
94Biliary tract neoplasm (HP:0100574)1.89929850
95Hypoplastic nipples (HP:0002557)1.89125504
96Hyperkalemia (HP:0002153)1.88852283
97Bundle branch block (HP:0011710)1.87525747
98Abnormality of ocular smooth pursuit (HP:0000617)1.86806143
99Myokymia (HP:0002411)1.86308548
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.85493779
101Tubular atrophy (HP:0000092)1.84138457
102Hypoplasia of dental enamel (HP:0006297)1.81255345
103Termporal pattern (HP:0011008)1.80406719
104Insidious onset (HP:0003587)1.80406719
105Insulin-resistant diabetes mellitus (HP:0000831)1.80167012
106Epileptiform EEG discharges (HP:0011182)1.79883479
107Aplasia/Hypoplasia of the fibula (HP:0006492)1.78814509
108Widely spaced teeth (HP:0000687)1.78532347
109Ankle clonus (HP:0011448)1.77782743
110Genital tract atresia (HP:0001827)1.75203214
111Mutism (HP:0002300)1.74507399
112Submucous cleft hard palate (HP:0000176)1.73773854
113Abnormal biliary tract morphology (HP:0012440)1.72878666
114Bell-shaped thorax (HP:0001591)1.72452490
115EEG with generalized epileptiform discharges (HP:0011198)1.71681709
116Hypsarrhythmia (HP:0002521)1.71636361
117Acute myeloid leukemia (HP:0004808)1.71019840
118Epileptic encephalopathy (HP:0200134)1.68163335
119Short chin (HP:0000331)1.68089638
120Neoplasm of the small intestine (HP:0100833)1.68086469
121Absent eyebrow (HP:0002223)1.67976429
122Hyperinsulinemic hypoglycemia (HP:0000825)1.67140263
123Complete atrioventricular canal defect (HP:0001674)1.65970406
124Gastroesophageal reflux (HP:0002020)1.65401854
125Abnormality of chromosome stability (HP:0003220)1.65148850
126Stage 5 chronic kidney disease (HP:0003774)1.64265918
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64122748
128Abnormality of salivation (HP:0100755)1.64051243
129Nephroblastoma (Wilms tumor) (HP:0002667)1.63688601
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63380890
131Heterotopia (HP:0002282)1.63092745
132Overgrowth (HP:0001548)1.62304899
133Vaginal atresia (HP:0000148)1.62289923
134Subaortic stenosis (HP:0001682)1.62101894
135Abnormality of the left ventricular outflow tract (HP:0011103)1.62101894
136Chronic hepatic failure (HP:0100626)1.61915813
137Neoplasm of the thyroid gland (HP:0100031)1.61519920
138Spastic paraplegia (HP:0001258)1.61350098
139Clonus (HP:0002169)1.60787848
140Embryonal renal neoplasm (HP:0011794)1.60734942
141Colon cancer (HP:0003003)1.59755100
142Thickened helices (HP:0000391)1.58996594
143Absent speech (HP:0001344)1.58420799
144Inability to walk (HP:0002540)1.57195362
145Median cleft lip (HP:0000161)1.55848875
146Capillary hemangiomas (HP:0005306)1.55246050
147Gait imbalance (HP:0002141)1.54627420
148Thyroid carcinoma (HP:0002890)1.54078035
149Abnormality of permanent molar morphology (HP:0011071)1.52635888
150Abnormality of the dental root (HP:0006486)1.52635888
151Taurodontia (HP:0000679)1.52635888
152Spastic tetraparesis (HP:0001285)1.51391963
153Postaxial foot polydactyly (HP:0001830)1.51221045
154Upper motor neuron abnormality (HP:0002127)1.51101450
155Urinary bladder sphincter dysfunction (HP:0002839)1.50140513
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49863234
157Abnormality of molar morphology (HP:0011070)1.49179696
158Abnormality of molar (HP:0011077)1.49179696
159Impaired proprioception (HP:0010831)1.49169532
160Shoulder girdle muscle weakness (HP:0003547)1.49140008
161Progressive inability to walk (HP:0002505)1.47034478
162Congenital primary aphakia (HP:0007707)1.46919100
163Congenital hepatic fibrosis (HP:0002612)1.46682496
164Broad-based gait (HP:0002136)1.46334997
165Muscle fiber splitting (HP:0003555)1.46277113
166Decreased motor nerve conduction velocity (HP:0003431)1.46092802
167Postaxial hand polydactyly (HP:0001162)1.43408081
168Poor coordination (HP:0002370)1.42298296
169Visual hallucinations (HP:0002367)1.41378266
170Abnormality of the frontal sinuses (HP:0002687)1.40262539
171Absence seizures (HP:0002121)1.40107843
172Truncal obesity (HP:0001956)1.39453186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.89215125
2PDK45.89215125
3PDK24.03516992
4PNCK3.09078159
5FRK2.39240941
6LATS12.39094703
7RIPK42.27468413
8NTRK32.04834476
9MAP3K41.95956363
10STK31.91307544
11STK391.86345896
12AKT31.81868393
13MST41.80922719
14TRIM281.80616309
15PRKD31.69226649
16ERBB31.67420965
17LATS21.66661692
18PTK2B1.64048808
19ACVR1B1.61636462
20NUAK11.60582990
21PINK11.57284905
22CDK31.52337074
23STK38L1.50126703
24MAP2K71.49991450
25STK381.49857840
26WNK11.48094831
27EPHA41.40846716
28BRD41.39872944
29WNK41.34212735
30BRSK21.33264665
31MAP2K41.25977302
32CASK1.23170374
33FGFR21.16467857
34NEK61.15779887
35PLK41.12606430
36NEK21.11997106
37CCNB11.05194173
38CAMK1G1.02761421
39MAP3K91.02354191
40UHMK11.01571220
41NLK1.01061102
42PLK20.98348285
43EPHA30.93890382
44MKNK10.90869616
45TIE10.89661447
46PAK60.88671190
47YES10.87815307
48ZAK0.84529041
49MAP3K60.82136766
50PRKAA10.81044108
51EIF2AK30.77862578
52NTRK20.76255044
53MAPK130.75845561
54INSRR0.75420640
55PLK30.75326184
56SGK20.75266447
57CAMKK20.73058135
58PDK10.72531689
59BMPR20.71587090
60DYRK30.71369022
61STK110.70496233
62PBK0.69721189
63TYRO30.68979520
64CAMK40.67954830
65SIK20.67947636
66PHKG20.66885515
67PHKG10.66885515
68PAK30.66319535
69MARK10.65524017
70MAP3K120.64186298
71MAP3K20.62308758
72GRK50.61981991
73GRK70.61599871
74CHEK20.61381200
75MAPK100.60637533
76DYRK20.59077521
77GRK10.58204412
78SGK10.57990606
79CAMK2A0.57417772
80MINK10.56990909
81PKN10.56821549
82PRKCG0.56622027
83WNK30.55807104
84ATM0.55171065
85MUSK0.54296701
86CSNK1G20.52734642
87DMPK0.52222623
88FER0.52087831
89DYRK1A0.52000662
90KSR10.51548797
91WEE10.50542328
92RPS6KB10.49325177
93MAP4K20.49115055
94TNIK0.48657914
95CSNK1D0.48186121
96FGFR10.47187632
97MKNK20.47129449
98CAMK10.46771817
99PIK3CA0.46728267
100OBSCN0.46522507
101PDGFRB0.46222605
102CSNK1A1L0.45655870
103NTRK10.45449312
104MARK20.44356108
105CAMKK10.44229715
106ERBB40.43921206
107BCR0.43912286
108BMPR1B0.43871226
109TTK0.42639837
110SIK30.42502607
111CHEK10.41947077
112CAMK1D0.40765285
113CDK50.39489982
114MAPK150.39406797
115PDPK10.39203619
116IRAK10.38852388
117CDK190.38656444
118PRKCE0.38611933
119CSNK1G10.38576747
120FGFR30.38549063
121CSNK1E0.37698591
122SGK30.36697663
123PRKAA20.36044182
124SGK2230.34178062
125SGK4940.34178062
126RAF10.33975282
127MARK30.33332832
128RPS6KA30.32697728
129BRSK10.32642206
130OXSR10.32202923
131STK240.32192453

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.08698140
2Dorso-ventral axis formation_Homo sapiens_hsa043202.62886621
3Nicotine addiction_Homo sapiens_hsa050332.61164803
4Amphetamine addiction_Homo sapiens_hsa050312.50458343
5Long-term potentiation_Homo sapiens_hsa047202.32118004
6Non-homologous end-joining_Homo sapiens_hsa034501.96901390
7Oocyte meiosis_Homo sapiens_hsa041141.86807131
8Renin secretion_Homo sapiens_hsa049241.82983675
9Circadian rhythm_Homo sapiens_hsa047101.73751740
10Glutamatergic synapse_Homo sapiens_hsa047241.72386481
11Taste transduction_Homo sapiens_hsa047421.68302419
12Circadian entrainment_Homo sapiens_hsa047131.61395990
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61211091
14Glucagon signaling pathway_Homo sapiens_hsa049221.59232866
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56324991
16Salivary secretion_Homo sapiens_hsa049701.51790561
17Basal transcription factors_Homo sapiens_hsa030221.44866237
18Insulin secretion_Homo sapiens_hsa049111.41622614
19Oxytocin signaling pathway_Homo sapiens_hsa049211.40561355
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40277812
21Calcium signaling pathway_Homo sapiens_hsa040201.38799450
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.38659149
23Morphine addiction_Homo sapiens_hsa050321.35873777
24Dopaminergic synapse_Homo sapiens_hsa047281.31651490
25Olfactory transduction_Homo sapiens_hsa047401.31427469
26Synaptic vesicle cycle_Homo sapiens_hsa047211.27585177
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18848884
28cAMP signaling pathway_Homo sapiens_hsa040241.18137199
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16619485
30Estrogen signaling pathway_Homo sapiens_hsa049151.16116063
31Inositol phosphate metabolism_Homo sapiens_hsa005621.15377536
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15119759
33Serotonergic synapse_Homo sapiens_hsa047261.11089125
34Collecting duct acid secretion_Homo sapiens_hsa049661.07703901
35Type II diabetes mellitus_Homo sapiens_hsa049301.07455184
36GABAergic synapse_Homo sapiens_hsa047271.06894078
37Cocaine addiction_Homo sapiens_hsa050301.06680738
38GnRH signaling pathway_Homo sapiens_hsa049121.06614446
39Propanoate metabolism_Homo sapiens_hsa006401.05661808
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05152997
41Vitamin digestion and absorption_Homo sapiens_hsa049771.03834774
42Fanconi anemia pathway_Homo sapiens_hsa034601.02499546
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01917096
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01309253
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01162742
46Long-term depression_Homo sapiens_hsa047301.01016508
47RNA degradation_Homo sapiens_hsa030181.00952620
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.00632407
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00306056
50Gastric acid secretion_Homo sapiens_hsa049710.99277252
51Tight junction_Homo sapiens_hsa045300.97397605
52Regulation of autophagy_Homo sapiens_hsa041400.96057288
53Choline metabolism in cancer_Homo sapiens_hsa052310.94824240
54Cholinergic synapse_Homo sapiens_hsa047250.94615311
55TGF-beta signaling pathway_Homo sapiens_hsa043500.93659851
56Colorectal cancer_Homo sapiens_hsa052100.91060755
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89073682
58Hippo signaling pathway_Homo sapiens_hsa043900.89014769
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88372609
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87943585
61FoxO signaling pathway_Homo sapiens_hsa040680.87357117
62Steroid biosynthesis_Homo sapiens_hsa001000.83570075
63Sphingolipid metabolism_Homo sapiens_hsa006000.82796511
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82234062
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81991485
66Endometrial cancer_Homo sapiens_hsa052130.81768651
67Axon guidance_Homo sapiens_hsa043600.80684666
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80156514
69Mineral absorption_Homo sapiens_hsa049780.79575370
70Glycerolipid metabolism_Homo sapiens_hsa005610.79400910
71MAPK signaling pathway_Homo sapiens_hsa040100.78675348
72Phototransduction_Homo sapiens_hsa047440.76783389
73Fatty acid biosynthesis_Homo sapiens_hsa000610.73882502
74Ovarian steroidogenesis_Homo sapiens_hsa049130.73304139
75MicroRNAs in cancer_Homo sapiens_hsa052060.72854001
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71833327
77ErbB signaling pathway_Homo sapiens_hsa040120.71069348
78Pancreatic secretion_Homo sapiens_hsa049720.70877378
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70417588
80VEGF signaling pathway_Homo sapiens_hsa043700.70240800
81Thyroid hormone synthesis_Homo sapiens_hsa049180.69391816
82Glioma_Homo sapiens_hsa052140.65167845
83RNA transport_Homo sapiens_hsa030130.63880948
84Wnt signaling pathway_Homo sapiens_hsa043100.63697379
85mTOR signaling pathway_Homo sapiens_hsa041500.63526380
86Lysine degradation_Homo sapiens_hsa003100.63139188
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58091899
88* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58036700
89Alcoholism_Homo sapiens_hsa050340.57211837
90Hedgehog signaling pathway_Homo sapiens_hsa043400.55419944
91Melanogenesis_Homo sapiens_hsa049160.55364518
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.54552850
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54536446
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54207168
95Dilated cardiomyopathy_Homo sapiens_hsa054140.53776275
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53381125
97Gap junction_Homo sapiens_hsa045400.52610987
98Rap1 signaling pathway_Homo sapiens_hsa040150.52488507
99Cell cycle_Homo sapiens_hsa041100.52300256
100p53 signaling pathway_Homo sapiens_hsa041150.52164698
101Protein export_Homo sapiens_hsa030600.51898299
102Linoleic acid metabolism_Homo sapiens_hsa005910.51338870
103Prolactin signaling pathway_Homo sapiens_hsa049170.51139347
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50725234
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49923365
106Ras signaling pathway_Homo sapiens_hsa040140.49529929
107AMPK signaling pathway_Homo sapiens_hsa041520.48781699
108Selenocompound metabolism_Homo sapiens_hsa004500.48438776
109Ether lipid metabolism_Homo sapiens_hsa005650.48020739
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47214786
111mRNA surveillance pathway_Homo sapiens_hsa030150.47195325
112Rheumatoid arthritis_Homo sapiens_hsa053230.44968452
113Prostate cancer_Homo sapiens_hsa052150.44938647
114Adherens junction_Homo sapiens_hsa045200.39672040
115ECM-receptor interaction_Homo sapiens_hsa045120.39129404
116Renal cell carcinoma_Homo sapiens_hsa052110.36909551
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35481851
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.35452138
119Endocytosis_Homo sapiens_hsa041440.35337212
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.34823393
121ABC transporters_Homo sapiens_hsa020100.34008234

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