RBBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.13865214
2DNA double-strand break processing (GO:0000729)5.35935023
3protein localization to kinetochore (GO:0034501)4.86792301
4DNA strand elongation involved in DNA replication (GO:0006271)4.80058277
5nuclear pore organization (GO:0006999)4.57667789
6DNA strand elongation (GO:0022616)4.54117666
7mitotic chromosome condensation (GO:0007076)4.50995260
8DNA replication initiation (GO:0006270)4.47984505
9nuclear pore complex assembly (GO:0051292)4.34892801
10telomere maintenance via semi-conservative replication (GO:0032201)4.28424612
11sister chromatid segregation (GO:0000819)4.22911604
12mitotic sister chromatid segregation (GO:0000070)4.06946737
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05283069
14* DNA replication-dependent nucleosome assembly (GO:0006335)4.01874457
15* DNA replication-dependent nucleosome organization (GO:0034723)4.01874457
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.00923211
17protein localization to chromosome, centromeric region (GO:0071459)4.00277998
18mitotic recombination (GO:0006312)3.98191328
19DNA ligation (GO:0006266)3.97661462
20mitotic nuclear envelope disassembly (GO:0007077)3.94270773
21* histone exchange (GO:0043486)3.92508299
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.91754048
23replication fork processing (GO:0031297)3.88437094
24telomere maintenance via recombination (GO:0000722)3.84094049
25folic acid-containing compound biosynthetic process (GO:0009396)3.83895747
26DNA duplex unwinding (GO:0032508)3.79968299
27mitotic sister chromatid cohesion (GO:0007064)3.79432150
28DNA geometric change (GO:0032392)3.77651527
29DNA topological change (GO:0006265)3.77176836
30IMP biosynthetic process (GO:0006188)3.69880204
31histone H2A acetylation (GO:0043968)3.69619417
32negative regulation of RNA splicing (GO:0033119)3.67968727
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.66863035
34nuclear envelope disassembly (GO:0051081)3.66582230
35membrane disassembly (GO:0030397)3.66582230
36non-recombinational repair (GO:0000726)3.66035489
37double-strand break repair via nonhomologous end joining (GO:0006303)3.66035489
38negative regulation of DNA recombination (GO:0045910)3.65344631
39translesion synthesis (GO:0019985)3.61363001
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.58596108
41dosage compensation (GO:0007549)3.57443204
42kinetochore assembly (GO:0051382)3.52859546
43DNA replication checkpoint (GO:0000076)3.50124837
44negative regulation of mRNA processing (GO:0050686)3.49900100
45purine nucleobase biosynthetic process (GO:0009113)3.46153528
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.45629750
47regulation of histone H3-K9 methylation (GO:0051570)3.45249094
48attachment of spindle microtubules to kinetochore (GO:0008608)3.44370728
49DNA catabolic process, exonucleolytic (GO:0000738)3.43886729
50ribosomal small subunit assembly (GO:0000028)3.40407853
51telomere maintenance via telomere lengthening (GO:0010833)3.39323964
52postreplication repair (GO:0006301)3.38186135
53mitotic metaphase plate congression (GO:0007080)3.32719862
54* DNA replication-independent nucleosome organization (GO:0034724)3.31038434
55* DNA replication-independent nucleosome assembly (GO:0006336)3.31038434
56kinetochore organization (GO:0051383)3.27901122
57nucleobase biosynthetic process (GO:0046112)3.27018363
58positive regulation of chromosome segregation (GO:0051984)3.23871308
59DNA conformation change (GO:0071103)3.23585562
60regulation of sister chromatid cohesion (GO:0007063)3.22985286
61mitotic spindle checkpoint (GO:0071174)3.22429478
62IMP metabolic process (GO:0046040)3.22299971
63mRNA splicing, via spliceosome (GO:0000398)3.21178442
64RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.21178442
65viral transcription (GO:0019083)3.20641074
66formation of translation preinitiation complex (GO:0001731)3.20365853
67DNA strand renaturation (GO:0000733)3.19577737
68pore complex assembly (GO:0046931)3.18883931
69RNA splicing, via transesterification reactions (GO:0000375)3.18051245
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17718128
71regulation of mitotic spindle checkpoint (GO:1903504)3.17718128
72establishment of integrated proviral latency (GO:0075713)3.17525514
73* chromatin assembly or disassembly (GO:0006333)3.17068251
74maturation of SSU-rRNA (GO:0030490)3.15064818
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.15036785
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15036785
77* chromatin remodeling at centromere (GO:0031055)3.14637749
78chromosome condensation (GO:0030261)3.14324950
79resolution of meiotic recombination intermediates (GO:0000712)3.13850404
80spliceosomal tri-snRNP complex assembly (GO:0000244)3.13239687
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13000569
82translational termination (GO:0006415)3.12533640
83metaphase plate congression (GO:0051310)3.12012125
84regulation of chromosome segregation (GO:0051983)3.10659859
85heterochromatin organization (GO:0070828)3.10324246
86mitotic G2/M transition checkpoint (GO:0044818)3.09773978
87pre-miRNA processing (GO:0031054)3.08420732
88microtubule depolymerization (GO:0007019)3.07997167
89DNA damage response, detection of DNA damage (GO:0042769)3.07397806
90negative regulation of mRNA metabolic process (GO:1903312)3.07298424
91regulation of spindle organization (GO:0090224)3.07111445
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06511618
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06511618
94* CENP-A containing nucleosome assembly (GO:0034080)3.05200551
95negative regulation of histone methylation (GO:0031061)3.04557491
96termination of RNA polymerase II transcription (GO:0006369)3.02975885
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01096349
98* ATP-dependent chromatin remodeling (GO:0043044)3.00188780
99cullin deneddylation (GO:0010388)2.99103132
100regulation of RNA export from nucleus (GO:0046831)2.97500918
101regulation of mitotic sister chromatid separation (GO:0010965)2.97393799
102regulation of mitotic sister chromatid segregation (GO:0033047)2.97393799
103regulation of sister chromatid segregation (GO:0033045)2.97393799
104protein localization to chromosome (GO:0034502)2.96811459
105mitotic spindle assembly checkpoint (GO:0007094)2.96119214
106recombinational repair (GO:0000725)2.96026558
107centriole replication (GO:0007099)2.95487845
108meiotic chromosome segregation (GO:0045132)2.93791262
109double-strand break repair via homologous recombination (GO:0000724)2.93611730
110regulation of centrosome cycle (GO:0046605)2.93429998
111* chromatin assembly (GO:0031497)2.92869619
112synapsis (GO:0007129)2.92571507
113nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92086043
114nuclear envelope organization (GO:0006998)2.91957662
115mismatch repair (GO:0006298)2.91347295
116L-serine metabolic process (GO:0006563)2.90707797
117establishment of chromosome localization (GO:0051303)2.90253381
118RNA stabilization (GO:0043489)2.89906209
119mRNA stabilization (GO:0048255)2.89906209
120negative regulation of chromosome segregation (GO:0051985)2.89771895
121regulation of centriole replication (GO:0046599)2.89262869
122regulation of DNA endoreduplication (GO:0032875)2.89040524
123chromosome segregation (GO:0007059)2.87366340
124RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86894501
125translational elongation (GO:0006414)2.86781755
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.86777089
127spindle assembly checkpoint (GO:0071173)2.85640492
128regulation of posttranscriptional gene silencing (GO:0060147)2.85501835
129regulation of gene silencing by miRNA (GO:0060964)2.85501835
130regulation of gene silencing by RNA (GO:0060966)2.85501835
131regulation of helicase activity (GO:0051095)2.85284016
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.84843329
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84843329
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84843329
135negative regulation of sister chromatid segregation (GO:0033046)2.84843329
136spindle checkpoint (GO:0031577)2.84193731
137histone mRNA metabolic process (GO:0008334)2.83307607
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71905549
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71598658
140isotype switching (GO:0045190)2.71598658
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71598658
142regulation of mesoderm development (GO:2000380)2.71439811
143protein deneddylation (GO:0000338)2.71027382
144proteasome assembly (GO:0043248)2.70164515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.49569584
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31924821
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.73414125
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54228210
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32643582
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.85809007
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81540350
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48777074
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44071467
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39067149
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34681515
12EWS_26573619_Chip-Seq_HEK293_Human2.34435899
13AR_21909140_ChIP-Seq_LNCAP_Human2.32868303
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31061544
15XRN2_22483619_ChIP-Seq_HELA_Human2.27203723
16MYC_22102868_ChIP-Seq_BL_Human2.24770757
17ZNF274_21170338_ChIP-Seq_K562_Hela2.24604453
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23667594
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.23112387
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.15806471
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14776008
22FUS_26573619_Chip-Seq_HEK293_Human2.12831994
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06474307
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03722558
25IGF1R_20145208_ChIP-Seq_DFB_Human2.02971341
26E2F7_22180533_ChIP-Seq_HELA_Human10.5002264
27* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96994787
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96836964
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96364708
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90527553
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90044237
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.79589624
33* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78898155
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.72274791
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70709066
36VDR_23849224_ChIP-Seq_CD4+_Human1.68107747
37CIITA_25753668_ChIP-Seq_RAJI_Human1.66438374
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66250449
39TAF15_26573619_Chip-Seq_HEK293_Human1.66157161
40FOXP3_21729870_ChIP-Seq_TREG_Human1.65311656
41TTF2_22483619_ChIP-Seq_HELA_Human1.64246523
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61094295
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60934772
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59467935
45DCP1A_22483619_ChIP-Seq_HELA_Human1.57664851
46* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56649847
47VDR_22108803_ChIP-Seq_LS180_Human1.55919607
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55163879
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52587851
50P300_19829295_ChIP-Seq_ESCs_Human1.51917815
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51752585
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50071525
53* ELK1_19687146_ChIP-ChIP_HELA_Human1.48840238
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48518314
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48453216
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.46910038
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46328149
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46240311
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.43693213
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42985658
61* KDM5A_27292631_Chip-Seq_BREAST_Human1.42743291
62GABP_19822575_ChIP-Seq_HepG2_Human1.39294934
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39204327
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36633026
65* NANOG_16153702_ChIP-ChIP_HESCs_Human1.36487595
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35710347
67GBX2_23144817_ChIP-Seq_PC3_Human1.34286621
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33686264
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32271983
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.31141682
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30830646
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29000840
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28770133
74VDR_21846776_ChIP-Seq_THP-1_Human1.27301911
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26795830
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25865748
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24322240
78* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22308796
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22283993
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20862146
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19980774
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19197268
83IRF1_19129219_ChIP-ChIP_H3396_Human1.18228034
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18057411
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16380469
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15146594
87TFEB_21752829_ChIP-Seq_HELA_Human1.13812230
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13672876
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13672876
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13672876
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12352826
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.11944496
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11590782
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11427161
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11003772
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10739807
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10431597
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10321869
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.07018019
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06905454
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06535335
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06173089
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04451234
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04107125
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01856807
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01745892
107* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01091458
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.00775930
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99525573
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98076783
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.97428600
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97400084
113* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97078354
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96878529
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96682565
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94607333
117RNF2_27304074_Chip-Seq_NSC_Mouse0.94508541
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93730104
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93585367
120* CHD1_26751641_Chip-Seq_LNCaP_Human0.93320319
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93317725
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93231642
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92836251
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92711974
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92624608
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92621659
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92540979
128HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91971130
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.91403149
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90980151
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90912587
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90721570
133CBP_20019798_ChIP-Seq_JUKART_Human0.90721570
134UTX_26944678_Chip-Seq_JUKART_Human0.90693477
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90531953
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89681692
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88723556
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88101513
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87307013
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.84080917
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83983829
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83271539
143MYC_18940864_ChIP-ChIP_HL60_Human0.81626972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.26799096
2MP0004957_abnormal_blastocyst_morpholog3.67667566
3MP0003111_abnormal_nucleus_morphology3.65672513
4MP0003077_abnormal_cell_cycle3.49167946
5MP0003693_abnormal_embryo_hatching3.47633512
6MP0008057_abnormal_DNA_replication3.31677458
7MP0008007_abnormal_cellular_replicative2.80274891
8MP0003123_paternal_imprinting2.74108536
9MP0002102_abnormal_ear_morphology2.63057298
10MP0008058_abnormal_DNA_repair2.42892884
11MP0001730_embryonic_growth_arrest2.41406251
12MP0008932_abnormal_embryonic_tissue2.34173169
13MP0008877_abnormal_DNA_methylation2.28126310
14MP0000537_abnormal_urethra_morphology2.23601993
15MP0000350_abnormal_cell_proliferation2.21270803
16MP0010352_gastrointestinal_tract_polyps2.11189726
17MP0006292_abnormal_olfactory_placode2.08666939
18MP0010307_abnormal_tumor_latency2.06944050
19MP0003121_genomic_imprinting2.01719909
20MP0009697_abnormal_copulation1.98659084
21MP0001529_abnormal_vocalization1.97248774
22MP0005394_taste/olfaction_phenotype1.96866512
23MP0005499_abnormal_olfactory_system1.96866512
24MP0010030_abnormal_orbit_morphology1.92202710
25MP0004197_abnormal_fetal_growth/weight/1.89941652
26MP0005076_abnormal_cell_differentiation1.88772468
27MP0002396_abnormal_hematopoietic_system1.87037997
28MP0009053_abnormal_anal_canal1.84485963
29MP0002084_abnormal_developmental_patter1.84158254
30MP0001697_abnormal_embryo_size1.82057199
31MP0005380_embryogenesis_phenotype1.81605572
32MP0001672_abnormal_embryogenesis/_devel1.81605572
33MP0002085_abnormal_embryonic_tissue1.80794146
34MP0006054_spinal_hemorrhage1.80713739
35MP0008789_abnormal_olfactory_epithelium1.79627399
36MP0001188_hyperpigmentation1.79464663
37MP0006072_abnormal_retinal_apoptosis1.73853914
38MP0003880_abnormal_central_pattern1.70833811
39MP0003984_embryonic_growth_retardation1.64730464
40MP0008995_early_reproductive_senescence1.64399290
41MP0002080_prenatal_lethality1.63089482
42MP0002088_abnormal_embryonic_growth/wei1.62878097
43MP0004808_abnormal_hematopoietic_stem1.58759891
44MP0003567_abnormal_fetal_cardiomyocyte1.56556838
45MP0003718_maternal_effect1.54819649
46MP0002086_abnormal_extraembryonic_tissu1.54646661
47MP0003890_abnormal_embryonic-extraembry1.53058531
48MP0002751_abnormal_autonomic_nervous1.47845897
49MP0003786_premature_aging1.45541308
50MP0001984_abnormal_olfaction1.45436080
51MP0000372_irregular_coat_pigmentation1.41694132
52MP0003705_abnormal_hypodermis_morpholog1.39400831
53MP0001293_anophthalmia1.35712430
54MP0000428_abnormal_craniofacial_morphol1.27700738
55MP0003937_abnormal_limbs/digits/tail_de1.27661220
56MP0005253_abnormal_eye_physiology1.27035678
57MP0000313_abnormal_cell_death1.25039717
58MP0009672_abnormal_birth_weight1.23293895
59MP0000490_abnormal_crypts_of1.23010299
60MP0003119_abnormal_digestive_system1.22264779
61MP0002019_abnormal_tumor_incidence1.18544927
62MP0000733_abnormal_muscle_development1.18020593
63MP0002736_abnormal_nociception_after1.17617937
64MP0009278_abnormal_bone_marrow1.16868584
65MP0000703_abnormal_thymus_morphology1.15895730
66MP0002210_abnormal_sex_determination1.14844710
67MP0003315_abnormal_perineum_morphology1.14759180
68MP0000778_abnormal_nervous_system1.14206539
69MP0004147_increased_porphyrin_level1.13804772
70MP0002092_abnormal_eye_morphology1.09449794
71MP0002111_abnormal_tail_morphology1.09119413
72MP0001145_abnormal_male_reproductive1.05714302
73MP0001915_intracranial_hemorrhage1.05222787
74MP0009703_decreased_birth_body1.05130338
75MP0002234_abnormal_pharynx_morphology1.04492469
76MP0000647_abnormal_sebaceous_gland1.03014786
77MP0002697_abnormal_eye_size1.02629241
78MP0003115_abnormal_respiratory_system1.02214055
79MP0001177_atelectasis1.01918304
80MP0001849_ear_inflammation1.01890313
81MP0002009_preneoplasia0.99972529
82MP0003942_abnormal_urinary_system0.98887949
83MP0005391_vision/eye_phenotype0.98678720
84MP0005367_renal/urinary_system_phenotyp0.98134191
85MP0000516_abnormal_urinary_system0.98134191
86MP0000631_abnormal_neuroendocrine_gland0.97063032
87MP0003136_yellow_coat_color0.96852684
88MP0002932_abnormal_joint_morphology0.94500333
89MP0003385_abnormal_body_wall0.92655633
90MP0010234_abnormal_vibrissa_follicle0.92564439
91MP0005248_abnormal_Harderian_gland0.92254029
92MP0002653_abnormal_ependyma_morphology0.92044468
93MP0002282_abnormal_trachea_morphology0.91694798
94MP0002938_white_spotting0.91569115
95MP0006035_abnormal_mitochondrial_morpho0.91071718
96MP0003935_abnormal_craniofacial_develop0.91048824
97MP0001485_abnormal_pinna_reflex0.90764659
98MP0003122_maternal_imprinting0.90057711
99MP0001286_abnormal_eye_development0.88741905
100MP0003943_abnormal_hepatobiliary_system0.88703282
101MP0003763_abnormal_thymus_physiology0.86619183
102MP0003283_abnormal_digestive_organ0.86498719
103MP0001929_abnormal_gametogenesis0.86061409
104MP0003941_abnormal_skin_development0.85648941
105MP0001119_abnormal_female_reproductive0.85282899
106MP0004215_abnormal_myocardial_fiber0.85251170
107MP0002398_abnormal_bone_marrow0.84801273
108MP0000049_abnormal_middle_ear0.81554601
109MP0004233_abnormal_muscle_weight0.81352606
110MP0003698_abnormal_male_reproductive0.81004167
111MP0003861_abnormal_nervous_system0.80824816
112MP0002877_abnormal_melanocyte_morpholog0.80626714
113MP0000653_abnormal_sex_gland0.80476737
114MP0006276_abnormal_autonomic_nervous0.80443795
115MP0002925_abnormal_cardiovascular_devel0.79866009
116MP0004133_heterotaxia0.78232472
117MP0002722_abnormal_immune_system0.77824813
118MP0000432_abnormal_head_morphology0.77131738
119MP0003787_abnormal_imprinting0.77021715
120MP0005623_abnormal_meninges_morphology0.76655217
121MP0009333_abnormal_splenocyte_physiolog0.76313363
122MP0002184_abnormal_innervation0.74533948
123MP0005551_abnormal_eye_electrophysiolog0.73444328
124MP0002160_abnormal_reproductive_system0.73234648
125MP0002114_abnormal_axial_skeleton0.73070296
126MP0003755_abnormal_palate_morphology0.71698482
127MP0005023_abnormal_wound_healing0.70681511
128MP0000689_abnormal_spleen_morphology0.69798163
129MP0003566_abnormal_cell_adhesion0.69654132
130MP0002090_abnormal_vision0.67543022
131MP0005384_cellular_phenotype0.66633862
132MP0003938_abnormal_ear_development0.66444160
133MP0002081_perinatal_lethality0.65969767
134MP0000477_abnormal_intestine_morphology0.65263964
135MP0002752_abnormal_somatic_nervous0.65155041
136MP0000534_abnormal_ureter_morphology0.64634971
137MP0005187_abnormal_penis_morphology0.64457520
138MP0002116_abnormal_craniofacial_bone0.64018968
139MP0003221_abnormal_cardiomyocyte_apopto0.63553458
140MP0005621_abnormal_cell_physiology0.63346388
141MP0002233_abnormal_nose_morphology0.61464432
142MP0005389_reproductive_system_phenotype0.60956546
143MP0004134_abnormal_chest_morphology0.60573427

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.66130050
2Colon cancer (HP:0003003)3.53347272
3Medulloblastoma (HP:0002885)3.39602834
4Selective tooth agenesis (HP:0001592)3.36820986
5Cortical dysplasia (HP:0002539)3.28951766
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26165568
7Short 4th metacarpal (HP:0010044)3.26165568
8Reticulocytopenia (HP:0001896)3.23570171
9Increased nuchal translucency (HP:0010880)3.09356385
1011 pairs of ribs (HP:0000878)2.86503812
11Missing ribs (HP:0000921)2.85028865
12Renal duplication (HP:0000075)2.83578460
13Proximal placement of thumb (HP:0009623)2.81877254
14Birth length less than 3rd percentile (HP:0003561)2.81078751
15Volvulus (HP:0002580)2.79861678
16Deviation of the thumb (HP:0009603)2.72404582
17Chromsome breakage (HP:0040012)2.68499517
18Astrocytoma (HP:0009592)2.64575258
19Abnormality of the astrocytes (HP:0100707)2.64575258
20Intestinal atresia (HP:0011100)2.62439192
21Hypoplastic pelvis (HP:0008839)2.56734589
22Patellar aplasia (HP:0006443)2.56223296
23Abnormality of the 4th metacarpal (HP:0010012)2.56049323
24Hyperacusis (HP:0010780)2.55618351
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52530358
26Abnormality of the calcaneus (HP:0008364)2.50272806
27Ectopic kidney (HP:0000086)2.42654878
28Aplasia/Hypoplasia of the patella (HP:0006498)2.41978420
29Abnormality of chromosome stability (HP:0003220)2.38302995
30Abnormality of the labia minora (HP:0012880)2.37030726
31Triphalangeal thumb (HP:0001199)2.36765195
32Bifid tongue (HP:0010297)2.32260593
33Rhabdomyosarcoma (HP:0002859)2.32029301
34Meckel diverticulum (HP:0002245)2.30880495
35Basal cell carcinoma (HP:0002671)2.30681544
36Abnormal number of incisors (HP:0011064)2.30284756
37Clubbing of toes (HP:0100760)2.28654880
38Atresia of the external auditory canal (HP:0000413)2.26715213
39Abnormal lung lobation (HP:0002101)2.26447276
40Agnosia (HP:0010524)2.26085602
41Abnormality of the anterior horn cell (HP:0006802)2.23271642
42Degeneration of anterior horn cells (HP:0002398)2.23271642
43Glioma (HP:0009733)2.23125831
44High pitched voice (HP:0001620)2.21975068
45Methylmalonic acidemia (HP:0002912)2.20885750
46Neoplasm of the oral cavity (HP:0100649)2.19689120
47Abnormality of the ileum (HP:0001549)2.19644019
48Overriding aorta (HP:0002623)2.18239348
49Pancreatic cysts (HP:0001737)2.17541228
50Gonadotropin excess (HP:0000837)2.17199866
51Oligodactyly (hands) (HP:0001180)2.17132080
52Pseudobulbar signs (HP:0002200)2.15334980
53Neoplasm of the pancreas (HP:0002894)2.14872557
54Ovarian neoplasm (HP:0100615)2.13922052
55Nephroblastoma (Wilms tumor) (HP:0002667)2.10862617
56Renovascular hypertension (HP:0100817)2.08188533
57Metaphyseal cupping (HP:0003021)2.05821526
58True hermaphroditism (HP:0010459)2.05731805
59Breast hypoplasia (HP:0003187)2.05363603
60Duodenal stenosis (HP:0100867)2.04661839
61Small intestinal stenosis (HP:0012848)2.04661839
62Abnormality of cells of the erythroid lineage (HP:0012130)2.04492445
63Abnormal umbilical cord blood vessels (HP:0011403)2.04278674
64Single umbilical artery (HP:0001195)2.04278674
65Abnormality of the fetal cardiovascular system (HP:0010948)2.04278674
66Myelodysplasia (HP:0002863)2.03756566
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.03578005
68Pancreatic fibrosis (HP:0100732)2.02026828
69Increased density of long bones (HP:0006392)2.01768383
70Preaxial hand polydactyly (HP:0001177)2.00796649
71Absent radius (HP:0003974)1.99729957
72Hyperglycinemia (HP:0002154)1.97658785
73Abnormality of the carotid arteries (HP:0005344)1.97127884
74Facial hemangioma (HP:0000329)1.97063694
75Neoplasm of striated muscle (HP:0009728)1.96408135
76Embryonal renal neoplasm (HP:0011794)1.96313017
77Septo-optic dysplasia (HP:0100842)1.95990656
78Pancreatic islet-cell hyperplasia (HP:0004510)1.93630501
79Genital tract atresia (HP:0001827)1.93071318
80Cafe-au-lait spot (HP:0000957)1.89208822
81Gastrointestinal carcinoma (HP:0002672)1.89188474
82Malignant gastrointestinal tract tumors (HP:0006749)1.89188474
83Esophageal atresia (HP:0002032)1.88669207
84Amaurosis fugax (HP:0100576)1.88564648
85Vaginal atresia (HP:0000148)1.88437683
86High anterior hairline (HP:0009890)1.86503923
87Overlapping toe (HP:0001845)1.86384988
88Small hand (HP:0200055)1.85926670
89Pelvic girdle muscle weakness (HP:0003749)1.85057266
90Abnormal number of erythroid precursors (HP:0012131)1.84997076
91Absent forearm bone (HP:0003953)1.84424309
92Aplasia involving forearm bones (HP:0009822)1.84424309
93Absent thumb (HP:0009777)1.84260707
94Horseshoe kidney (HP:0000085)1.83704564
95Oral leukoplakia (HP:0002745)1.82995711
96Neoplasm of the adrenal gland (HP:0100631)1.82984105
97Bowel diverticulosis (HP:0005222)1.82155223
98Slender long bone (HP:0003100)1.82013297
99Abnormality of the duodenum (HP:0002246)1.81121607
100Postaxial foot polydactyly (HP:0001830)1.80958317
101Intestinal polyp (HP:0005266)1.80089116
102Dandy-Walker malformation (HP:0001305)1.79518145
103Abnormality of the diencephalon (HP:0010662)1.79393895
104Biliary tract neoplasm (HP:0100574)1.78932744
105Abnormality of methionine metabolism (HP:0010901)1.78725414
106Tracheoesophageal fistula (HP:0002575)1.77247582
107Intestinal polyposis (HP:0200008)1.77176354
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.77139260
109Hepatoblastoma (HP:0002884)1.76133257
110Shoulder girdle muscle weakness (HP:0003547)1.76033965
111Abnormality of the parathyroid morphology (HP:0011766)1.76023744
112Sloping forehead (HP:0000340)1.75285019
113Cutaneous melanoma (HP:0012056)1.74766044
114Trigonocephaly (HP:0000243)1.74122311
115Neoplasm of the adrenal cortex (HP:0100641)1.74116313
116Abnormal biliary tract physiology (HP:0012439)1.73984267
117Bile duct proliferation (HP:0001408)1.73984267
118Abnormality of the preputium (HP:0100587)1.73812125
119Skin tags (HP:0010609)1.73811776
120Renal hypoplasia (HP:0000089)1.73576976
121Oligodactyly (HP:0012165)1.73358716
122Anophthalmia (HP:0000528)1.73084136
123Skull defect (HP:0001362)1.73040939
124Elfin facies (HP:0004428)1.72591468
125Abnormality of glycine metabolism (HP:0010895)1.72313364
126Abnormality of serine family amino acid metabolism (HP:0010894)1.72313364
127Broad palm (HP:0001169)1.71391387
128Preauricular skin tag (HP:0000384)1.70232389
129Abdominal situs inversus (HP:0003363)1.70208196
130Abnormality of abdominal situs (HP:0011620)1.70208196
131Deep philtrum (HP:0002002)1.69940617
132Cutis marmorata (HP:0000965)1.69381475
133Arteriovenous malformation (HP:0100026)1.69344239
134Neoplasm of the colon (HP:0100273)1.68984644
135Supernumerary spleens (HP:0009799)1.68600113
136Congenital primary aphakia (HP:0007707)1.68497279
137Abnormality of chromosome segregation (HP:0002916)1.68337843
138Ankle contracture (HP:0006466)1.67411669
139Abnormality of midbrain morphology (HP:0002418)1.67299115
140Molar tooth sign on MRI (HP:0002419)1.67299115
141Medial flaring of the eyebrow (HP:0010747)1.67106611
142Progressive inability to walk (HP:0002505)1.65991392
143Long eyelashes (HP:0000527)1.64364843
144Astigmatism (HP:0000483)1.64128464
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.63972745
146Abnormality of glycolysis (HP:0004366)1.62338842
147Hyperglycinuria (HP:0003108)1.61417606
148Choanal atresia (HP:0000453)1.60975988
149Gait imbalance (HP:0002141)1.59917183
150Nephrogenic diabetes insipidus (HP:0009806)1.59092009
151Hypoplastic female external genitalia (HP:0012815)1.58938620
152Gastrointestinal atresia (HP:0002589)1.58146507
153Oligohydramnios (HP:0001562)1.58073823
154Methylmalonic aciduria (HP:0012120)1.58023441
155Irregular epiphyses (HP:0010582)1.57984888
156Nephronophthisis (HP:0000090)1.57717768
157Increased serum pyruvate (HP:0003542)1.57661501
158Aqueductal stenosis (HP:0002410)1.57404540
159Carpal bone hypoplasia (HP:0001498)1.57305431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.94858878
2WEE13.42259348
3TRIM283.28461046
4BUB13.09843752
5EEF2K2.99033598
6NEK22.75799695
7PASK2.74044054
8WNK32.56413510
9CDK122.55927158
10BMPR1B2.52415689
11NEK12.36581648
12NUAK12.35699080
13TSSK62.31390183
14PBK2.25988222
15MAP3K102.23733113
16MKNK12.22033942
17TESK22.20256243
18SRPK12.20231688
19PKN22.15087371
20RPS6KB22.10598117
21BCR2.04708764
22TNIK2.00598483
23ZAK1.91730698
24TTK1.88970021
25MAP4K21.88076722
26EIF2AK11.73551800
27TGFBR11.71087385
28ACVR1B1.70336661
29BRSK21.69616475
30ATR1.68832147
31CDK71.63098845
32MAP3K41.59977959
33PLK11.57381344
34TLK11.55698376
35BRD41.54768101
36VRK21.53600220
37PAK41.52711710
38TRIB31.48242318
39AURKB1.46147083
40SCYL21.45499221
41MKNK21.45161995
42CDK41.44950207
43MST41.44687889
44PLK21.41915497
45PLK31.40313174
46STK101.36466892
47CHEK11.31479669
48MAP3K81.28779348
49CSNK1G11.28577519
50MAPK131.28456309
51CDK61.25682646
52DYRK31.20191933
53ALK1.17406824
54CASK1.16980769
55STK41.16360079
56FRK1.15744732
57FLT31.14877327
58LRRK21.14488919
59TESK11.12929496
60CSNK1G21.12030116
61BRSK11.12020737
62SIK31.11262346
63VRK11.08361623
64PTK61.05757217
65EIF2AK21.03665928
66MAP2K71.02956438
67CHEK21.02887492
68PNCK1.02247213
69CLK11.01996425
70RPS6KA41.00638559
71TAF11.00318334
72ATM0.96667578
73LIMK10.94677477
74DYRK20.92327104
75ERBB40.91814026
76CCNB10.89397030
77EPHA40.89344400
78CDK20.87934634
79MELK0.86028962
80MINK10.85140833
81PLK40.79345620
82PAK20.76610026
83AURKA0.76564829
84MTOR0.74490152
85CDK10.74389415
86TTN0.74337247
87ICK0.73872195
88PDGFRA0.69326340
89EIF2AK30.66381493
90STK390.65004787
91CDK30.64796085
92PIM10.64558415
93DYRK1B0.64530854
94MARK10.64354503
95FGFR10.63777138
96STK30.63739952
97MAP4K10.61590648
98BCKDK0.59745010
99STK38L0.57630625
100LATS10.56744730
101GRK10.55158981
102CSNK2A20.54982191
103ILK0.54904076
104FER0.53462674
105PAK10.52854865
106PRKDC0.52236369
107UHMK10.50174935
108CDK90.49670494
109PRKD30.48860473
110EPHA20.48394533
111INSRR0.46321039
112CSNK1D0.45556789
113OXSR10.44718341
114BTK0.44544533
115CDK180.43904728
116CDK80.43214418
117ITK0.43122765
118GRK60.42287622
119PINK10.41774607
120TYRO30.41721691
121PDK20.41151019
122CSNK1A1L0.40827402
123CSNK2A10.40547726
124YES10.37166752
125RPS6KA50.36807173
126KSR10.36316339
127STK160.36213693
128CSNK1E0.35988047
129NME20.35775861
130MAPK140.34607683
131KDR0.34257089
132AKT20.32943290
133AKT10.32756698
134CSNK1G30.32695857
135FGFR20.32381085
136PRKCE0.31904015
137NLK0.30684541
138CSF1R0.29148459
139ERBB30.29101437
140CDK140.27451155
141CDK11A0.27142721
142CDK150.26669192
143CSNK1A10.26421203
144PRKCG0.26248226
145MAPK110.25235851
146MAPK10.23560536

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.12828337
2Mismatch repair_Homo sapiens_hsa034304.43260551
3Spliceosome_Homo sapiens_hsa030403.60605680
4Cell cycle_Homo sapiens_hsa041103.06173103
5Base excision repair_Homo sapiens_hsa034102.95005438
6RNA transport_Homo sapiens_hsa030132.94531125
7One carbon pool by folate_Homo sapiens_hsa006702.91044605
8Nucleotide excision repair_Homo sapiens_hsa034202.83415102
9Homologous recombination_Homo sapiens_hsa034402.70552849
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67966515
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52099791
12Non-homologous end-joining_Homo sapiens_hsa034502.38399074
13Ribosome_Homo sapiens_hsa030102.36236093
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32230700
15mRNA surveillance pathway_Homo sapiens_hsa030152.31260218
16Propanoate metabolism_Homo sapiens_hsa006402.24816726
17Steroid biosynthesis_Homo sapiens_hsa001002.16823661
18Fanconi anemia pathway_Homo sapiens_hsa034602.08592362
19Proteasome_Homo sapiens_hsa030501.75905833
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73768179
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70125593
22Systemic lupus erythematosus_Homo sapiens_hsa053221.67699104
23RNA polymerase_Homo sapiens_hsa030201.66439298
24RNA degradation_Homo sapiens_hsa030181.65217455
25Pyrimidine metabolism_Homo sapiens_hsa002401.54072827
26p53 signaling pathway_Homo sapiens_hsa041151.53944151
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52777214
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47642397
29Antigen processing and presentation_Homo sapiens_hsa046121.45205440
30Viral carcinogenesis_Homo sapiens_hsa052031.41789345
31Pyruvate metabolism_Homo sapiens_hsa006201.41084099
32Butanoate metabolism_Homo sapiens_hsa006501.39859032
33Basal transcription factors_Homo sapiens_hsa030221.34768890
34Fatty acid elongation_Homo sapiens_hsa000621.32626496
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27104881
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25326033
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18271079
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16954255
39Epstein-Barr virus infection_Homo sapiens_hsa051691.16735317
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16129896
41MicroRNAs in cancer_Homo sapiens_hsa052061.13885188
42HTLV-I infection_Homo sapiens_hsa051661.13045350
43Small cell lung cancer_Homo sapiens_hsa052221.11133715
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10120013
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07791296
46Oocyte meiosis_Homo sapiens_hsa041141.06040801
47Selenocompound metabolism_Homo sapiens_hsa004501.05570927
48Colorectal cancer_Homo sapiens_hsa052101.04473103
49Basal cell carcinoma_Homo sapiens_hsa052171.02942824
50Fatty acid metabolism_Homo sapiens_hsa012120.99672606
51Chronic myeloid leukemia_Homo sapiens_hsa052200.97817015
52Herpes simplex infection_Homo sapiens_hsa051680.95373077
53Hippo signaling pathway_Homo sapiens_hsa043900.93873362
54Vitamin B6 metabolism_Homo sapiens_hsa007500.88202945
55TGF-beta signaling pathway_Homo sapiens_hsa043500.87136370
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85898003
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85711753
58Primary immunodeficiency_Homo sapiens_hsa053400.85641445
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85008125
60Notch signaling pathway_Homo sapiens_hsa043300.82850791
61Thyroid cancer_Homo sapiens_hsa052160.81744268
62Alcoholism_Homo sapiens_hsa050340.81636122
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79563773
64Lysine degradation_Homo sapiens_hsa003100.78112473
65Phototransduction_Homo sapiens_hsa047440.77709325
66Biosynthesis of amino acids_Homo sapiens_hsa012300.77595078
67Parkinsons disease_Homo sapiens_hsa050120.75428444
68Hedgehog signaling pathway_Homo sapiens_hsa043400.73373293
69Viral myocarditis_Homo sapiens_hsa054160.72321325
70Adherens junction_Homo sapiens_hsa045200.71071217
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.70046459
72Peroxisome_Homo sapiens_hsa041460.64995384
73Prostate cancer_Homo sapiens_hsa052150.63130369
74Huntingtons disease_Homo sapiens_hsa050160.62367511
75Purine metabolism_Homo sapiens_hsa002300.62137395
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61893898
77Pancreatic cancer_Homo sapiens_hsa052120.61055325
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.59982717
79Bladder cancer_Homo sapiens_hsa052190.59631262
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58936628
81Non-small cell lung cancer_Homo sapiens_hsa052230.58038525
82Glutathione metabolism_Homo sapiens_hsa004800.57276877
83Pathways in cancer_Homo sapiens_hsa052000.57191569
84Shigellosis_Homo sapiens_hsa051310.56739336
85Hepatitis B_Homo sapiens_hsa051610.56262845
86Nicotine addiction_Homo sapiens_hsa050330.55914489
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.55290076
88Proteoglycans in cancer_Homo sapiens_hsa052050.53484850
89Apoptosis_Homo sapiens_hsa042100.52104238
90Pentose phosphate pathway_Homo sapiens_hsa000300.52061873
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51965777
92Oxidative phosphorylation_Homo sapiens_hsa001900.51032407
93Fatty acid degradation_Homo sapiens_hsa000710.50629636
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.49673606
95mTOR signaling pathway_Homo sapiens_hsa041500.49185367
96Endometrial cancer_Homo sapiens_hsa052130.48916092
97Metabolic pathways_Homo sapiens_hsa011000.48257819
98Legionellosis_Homo sapiens_hsa051340.48018980
99N-Glycan biosynthesis_Homo sapiens_hsa005100.47989418
100Tight junction_Homo sapiens_hsa045300.47639755
101beta-Alanine metabolism_Homo sapiens_hsa004100.45233847
102T cell receptor signaling pathway_Homo sapiens_hsa046600.44173753
103Focal adhesion_Homo sapiens_hsa045100.43581218
104Measles_Homo sapiens_hsa051620.43140147
105Wnt signaling pathway_Homo sapiens_hsa043100.43075763
106Olfactory transduction_Homo sapiens_hsa047400.40885721
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40849328
108Protein export_Homo sapiens_hsa030600.37662504
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37486380
110Nitrogen metabolism_Homo sapiens_hsa009100.37387897
111B cell receptor signaling pathway_Homo sapiens_hsa046620.35476965
112Acute myeloid leukemia_Homo sapiens_hsa052210.35452074
113Carbon metabolism_Homo sapiens_hsa012000.34836640
114Tryptophan metabolism_Homo sapiens_hsa003800.34519993
115Taste transduction_Homo sapiens_hsa047420.32948378
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32809352
117HIF-1 signaling pathway_Homo sapiens_hsa040660.32211906
118Renal cell carcinoma_Homo sapiens_hsa052110.32052571
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.29305927
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25825148
121Melanoma_Homo sapiens_hsa052180.25539407
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25259001
123FoxO signaling pathway_Homo sapiens_hsa040680.25021468
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24956263
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24711542
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.24422341
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.24335488
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23682088
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23453214
130ECM-receptor interaction_Homo sapiens_hsa045120.22452706
131Folate biosynthesis_Homo sapiens_hsa007900.21770511
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21704376
133Toxoplasmosis_Homo sapiens_hsa051450.21245768
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20977541
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20689155
136Arginine and proline metabolism_Homo sapiens_hsa003300.20577936
137Influenza A_Homo sapiens_hsa051640.20494344
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20460842
139Regulation of autophagy_Homo sapiens_hsa041400.20253351
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19328139
141GABAergic synapse_Homo sapiens_hsa047270.18544980
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18322853
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18104892
144Vitamin digestion and absorption_Homo sapiens_hsa049770.16380127
145Dopaminergic synapse_Homo sapiens_hsa047280.15654739
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13795001
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13289133
148Alzheimers disease_Homo sapiens_hsa050100.12193056
149Caffeine metabolism_Homo sapiens_hsa002320.11912682
150Retinol metabolism_Homo sapiens_hsa008300.11443176
151Circadian rhythm_Homo sapiens_hsa047100.10100750
152Fat digestion and absorption_Homo sapiens_hsa049750.09268700

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