RBBP4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.04991488
2DNA double-strand break processing (GO:0000729)4.84485392
3DNA replication-dependent nucleosome organization (GO:0034723)4.14190581
4DNA replication-dependent nucleosome assembly (GO:0006335)4.14190581
5cullin deneddylation (GO:0010388)4.04221857
6protein deneddylation (GO:0000338)3.98861136
7protein neddylation (GO:0045116)3.82075561
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80383726
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80383726
10response to pheromone (GO:0019236)3.70523689
11proteasome assembly (GO:0043248)3.69080987
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65143611
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58723216
14sequestering of actin monomers (GO:0042989)3.57947114
15chromatin remodeling at centromere (GO:0031055)3.57068233
16platelet dense granule organization (GO:0060155)3.54404798
17CENP-A containing nucleosome assembly (GO:0034080)3.52155042
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.50457683
19DNA damage response, detection of DNA damage (GO:0042769)3.48640276
20water-soluble vitamin biosynthetic process (GO:0042364)3.44488110
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43118747
22ubiquinone metabolic process (GO:0006743)3.40320986
23ubiquinone biosynthetic process (GO:0006744)3.38893981
24respiratory chain complex IV assembly (GO:0008535)3.36349929
25DNA catabolic process, exonucleolytic (GO:0000738)3.35587153
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.35198763
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.28911454
28regulation of mitotic spindle checkpoint (GO:1903504)3.28911454
29branched-chain amino acid catabolic process (GO:0009083)3.23959522
30base-excision repair, AP site formation (GO:0006285)3.19340993
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14839693
32protein-cofactor linkage (GO:0018065)3.12809628
33histone H2A acetylation (GO:0043968)3.11607046
34regulation of cellular amino acid metabolic process (GO:0006521)3.09042330
35preassembly of GPI anchor in ER membrane (GO:0016254)3.07362250
36somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06259601
37isotype switching (GO:0045190)3.06259601
38somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06259601
39pyrimidine nucleobase catabolic process (GO:0006208)3.05134580
40mannosylation (GO:0097502)3.04638279
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04262300
42DNA ligation (GO:0006266)3.03971345
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02546269
44signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02546269
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02546269
46cytidine deamination (GO:0009972)3.01577228
47cytidine metabolic process (GO:0046087)3.01577228
48cytidine catabolic process (GO:0006216)3.01577228
49L-methionine salvage (GO:0071267)2.95296626
50L-methionine biosynthetic process (GO:0071265)2.95296626
51amino acid salvage (GO:0043102)2.95296626
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94520193
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94520193
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94506195
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90399772
56establishment of protein localization to mitochondrial membrane (GO:0090151)2.90252648
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89255147
58DNA demethylation (GO:0080111)2.87354176
59signal transduction involved in cell cycle checkpoint (GO:0072395)2.86728193
60histone exchange (GO:0043486)2.84751223
61adenosine metabolic process (GO:0046085)2.84096697
62regulation of cilium movement (GO:0003352)2.83009496
63GPI anchor metabolic process (GO:0006505)2.82920012
64ATP synthesis coupled proton transport (GO:0015986)2.81961828
65energy coupled proton transport, down electrochemical gradient (GO:0015985)2.81961828
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80778641
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.80778641
68cytochrome complex assembly (GO:0017004)2.77141680
69somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76005643
70somatic hypermutation of immunoglobulin genes (GO:0016446)2.76005643
71histone mRNA metabolic process (GO:0008334)2.75319021
72positive regulation of protein homodimerization activity (GO:0090073)2.74852070
73protein complex biogenesis (GO:0070271)2.74462459
74metallo-sulfur cluster assembly (GO:0031163)2.73825899
75iron-sulfur cluster assembly (GO:0016226)2.73825899
76negative regulation of ligase activity (GO:0051352)2.72334016
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72334016
78quinone biosynthetic process (GO:1901663)2.70062995
79GPI anchor biosynthetic process (GO:0006506)2.69718132
80L-fucose catabolic process (GO:0042355)2.66514350
81fucose catabolic process (GO:0019317)2.66514350
82L-fucose metabolic process (GO:0042354)2.66514350
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.66194656
84termination of RNA polymerase III transcription (GO:0006386)2.66083265
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.66083265
86purine nucleobase biosynthetic process (GO:0009113)2.65712554
87mismatch repair (GO:0006298)2.65067038
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64097128
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.64097128
90NADH dehydrogenase complex assembly (GO:0010257)2.64097128
91peptidyl-histidine modification (GO:0018202)2.64089094
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63506922
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60661529
94mitochondrial respiratory chain complex assembly (GO:0033108)2.60427242
95organelle disassembly (GO:1903008)2.59430683
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58753414
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57863842
98postreplication repair (GO:0006301)2.57820802
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.56717112
100aldehyde catabolic process (GO:0046185)2.55894183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11763321
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.57973110
3ZNF274_21170338_ChIP-Seq_K562_Hela3.22292207
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20270259
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.05273278
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04046953
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95924344
8IGF1R_20145208_ChIP-Seq_DFB_Human2.92600036
9ELK1_19687146_ChIP-ChIP_HELA_Human2.56691070
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52634149
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.46404371
12VDR_23849224_ChIP-Seq_CD4+_Human2.35653041
13VDR_22108803_ChIP-Seq_LS180_Human2.33013088
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29856983
15TAF15_26573619_Chip-Seq_HEK293_Human2.28351393
16EWS_26573619_Chip-Seq_HEK293_Human2.24259324
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19778548
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13148204
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03457015
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.03034019
21FUS_26573619_Chip-Seq_HEK293_Human1.96057670
22FOXP3_21729870_ChIP-Seq_TREG_Human1.95619600
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90192638
24GBX2_23144817_ChIP-Seq_PC3_Human1.90094881
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89766034
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88609395
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88132869
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87939995
29MYC_18940864_ChIP-ChIP_HL60_Human1.84815039
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84399061
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84053016
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.81206606
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75647127
34P300_19829295_ChIP-Seq_ESCs_Human1.74855688
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65364607
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60942060
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.59558826
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58018870
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56552022
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55705835
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.46694147
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44490009
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42126067
44IRF1_19129219_ChIP-ChIP_H3396_Human1.39532774
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37212722
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36335858
47CBP_20019798_ChIP-Seq_JUKART_Human1.36335858
48TP53_22573176_ChIP-Seq_HFKS_Human1.36322533
49ER_23166858_ChIP-Seq_MCF-7_Human1.35217094
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34955768
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.30789654
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30370053
53DCP1A_22483619_ChIP-Seq_HELA_Human1.30086076
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29690671
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28640449
56SOX2_19829295_ChIP-Seq_ESCs_Human1.28218652
57NANOG_19829295_ChIP-Seq_ESCs_Human1.28218652
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28085926
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26401830
60GABP_19822575_ChIP-Seq_HepG2_Human1.24724860
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23858298
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.20760931
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.18246711
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18246711
65AR_20517297_ChIP-Seq_VCAP_Human1.17954324
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17371451
67E2F7_22180533_ChIP-Seq_HELA_Human1.14073302
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12748031
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11654034
70HTT_18923047_ChIP-ChIP_STHdh_Human1.11534325
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11228900
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07489304
73TCF4_22108803_ChIP-Seq_LS180_Human1.06531289
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03672058
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.03237453
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02710540
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01422874
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00537504
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99851657
80E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98668063
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98261074
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96726201
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95429285
84NCOR_22424771_ChIP-Seq_293T_Human0.95100397
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94639891
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94029430
87SMAD4_21799915_ChIP-Seq_A2780_Human0.93324282
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.92967517
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92966508
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92930703
91P53_22387025_ChIP-Seq_ESCs_Mouse0.92760374
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91991945
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.91103009
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.90646326
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89098018
96RNF2_27304074_Chip-Seq_NSC_Mouse0.89079333
97BCAT_22108803_ChIP-Seq_LS180_Human0.88546520
98AR_25329375_ChIP-Seq_VCAP_Human0.88450797
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.88080540
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.86799179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.47573811
2MP0008877_abnormal_DNA_methylation3.14826851
3MP0006072_abnormal_retinal_apoptosis2.80527418
4MP0008058_abnormal_DNA_repair2.79762612
5MP0001529_abnormal_vocalization2.65204962
6MP0004147_increased_porphyrin_level2.52213932
7MP0003786_premature_aging2.34666830
8MP0003195_calcinosis2.33278659
9MP0001984_abnormal_olfaction2.22106721
10MP0009697_abnormal_copulation2.11497179
11MP0000372_irregular_coat_pigmentation2.09914291
12MP0002736_abnormal_nociception_after2.05764939
13MP0010094_abnormal_chromosome_stability2.05609157
14MP0008789_abnormal_olfactory_epithelium2.05287806
15MP0005253_abnormal_eye_physiology1.99902624
16MP0006054_spinal_hemorrhage1.99344635
17MP0005084_abnormal_gallbladder_morpholo1.91856316
18MP0002837_dystrophic_cardiac_calcinosis1.87297245
19MP0001188_hyperpigmentation1.81731534
20MP0005551_abnormal_eye_electrophysiolog1.79212919
21MP0003787_abnormal_imprinting1.76730207
22MP0003122_maternal_imprinting1.76366503
23MP0005499_abnormal_olfactory_system1.76186248
24MP0005394_taste/olfaction_phenotype1.76186248
25MP0006035_abnormal_mitochondrial_morpho1.75521455
26MP0003880_abnormal_central_pattern1.74336355
27MP0006036_abnormal_mitochondrial_physio1.65656208
28MP0005645_abnormal_hypothalamus_physiol1.64919362
29MP0008995_early_reproductive_senescence1.64780841
30MP0001764_abnormal_homeostasis1.60944838
31MP0003011_delayed_dark_adaptation1.60893922
32MP0005671_abnormal_response_to1.58838718
33MP0003718_maternal_effect1.56589190
34MP0001968_abnormal_touch/_nociception1.55687809
35MP0002751_abnormal_autonomic_nervous1.55298043
36MP0006276_abnormal_autonomic_nervous1.51273898
37MP0008007_abnormal_cellular_replicative1.50453532
38MP0003121_genomic_imprinting1.49715426
39MP0009046_muscle_twitch1.41491538
40MP0004142_abnormal_muscle_tone1.39350726
41MP0008872_abnormal_physiological_respon1.38525220
42MP0005646_abnormal_pituitary_gland1.38461824
43MP0001986_abnormal_taste_sensitivity1.34089818
44MP0005075_abnormal_melanosome_morpholog1.33090488
45MP0004215_abnormal_myocardial_fiber1.31242297
46MP0008875_abnormal_xenobiotic_pharmacok1.29610419
47MP0002272_abnormal_nervous_system1.24731797
48MP0001905_abnormal_dopamine_level1.24412404
49MP0004043_abnormal_pH_regulation1.19175870
50MP0002234_abnormal_pharynx_morphology1.16372137
51MP0003137_abnormal_impulse_conducting1.15633149
52MP0003567_abnormal_fetal_cardiomyocyte1.12005144
53MP0004133_heterotaxia1.10574499
54MP0004145_abnormal_muscle_electrophysio1.09325893
55MP0003119_abnormal_digestive_system1.06669023
56MP0003693_abnormal_embryo_hatching1.06544489
57MP0006292_abnormal_olfactory_placode1.03374309
58MP0002090_abnormal_vision1.03307992
59MP0008932_abnormal_embryonic_tissue0.98016502
60MP0009745_abnormal_behavioral_response0.96633074
61MP0001485_abnormal_pinna_reflex0.95642429
62MP0001486_abnormal_startle_reflex0.94243188
63MP0005332_abnormal_amino_acid0.90728852
64MP0002166_altered_tumor_susceptibility0.89906564
65MP0005410_abnormal_fertilization0.87910841
66MP0009785_altered_susceptibility_to0.87758191
67MP0001501_abnormal_sleep_pattern0.87568332
68MP0001835_abnormal_antigen_presentation0.86636315
69MP0001929_abnormal_gametogenesis0.85498409
70MP0000631_abnormal_neuroendocrine_gland0.84996958
71MP0002638_abnormal_pupillary_reflex0.84438849
72MP0001293_anophthalmia0.84216900
73MP0004957_abnormal_blastocyst_morpholog0.84085843
74MP0001177_atelectasis0.83816734
75MP0002006_tumorigenesis0.83676460
76MP0003646_muscle_fatigue0.83385770
77MP0002557_abnormal_social/conspecific_i0.79586176
78MP0002572_abnormal_emotion/affect_behav0.79443408
79MP0003221_abnormal_cardiomyocyte_apopto0.79395965
80MP0010386_abnormal_urinary_bladder0.78742376
81MP0003186_abnormal_redox_activity0.77845366
82MP0000427_abnormal_hair_cycle0.77506697
83MP0000049_abnormal_middle_ear0.77122125
84MP0002653_abnormal_ependyma_morphology0.76522630
85MP0000647_abnormal_sebaceous_gland0.75468961
86MP0004885_abnormal_endolymph0.74505519
87MP0003806_abnormal_nucleotide_metabolis0.73721477
88MP0008775_abnormal_heart_ventricle0.73688175
89MP0002938_white_spotting0.73554461
90MP0009764_decreased_sensitivity_to0.71256977
91MP0004084_abnormal_cardiac_muscle0.70733449
92MP0001119_abnormal_female_reproductive0.70663234
93MP0000653_abnormal_sex_gland0.69660112
94MP0003937_abnormal_limbs/digits/tail_de0.69278031
95MP0002210_abnormal_sex_determination0.68585897
96MP0002184_abnormal_innervation0.68221503
97MP0002095_abnormal_skin_pigmentation0.67850808
98MP0002752_abnormal_somatic_nervous0.66948702
99MP0003252_abnormal_bile_duct0.66777812
100MP0005389_reproductive_system_phenotype0.66045452

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)3.73893391
2Renal cortical cysts (HP:0000803)3.60994729
3Pancreatic cysts (HP:0001737)3.21698439
4Methylmalonic aciduria (HP:0012120)3.02664149
5Abnormality of midbrain morphology (HP:0002418)2.99497293
6Molar tooth sign on MRI (HP:0002419)2.99497293
7Medial flaring of the eyebrow (HP:0010747)2.96573282
8Acute necrotizing encephalopathy (HP:0006965)2.96100067
9Severe combined immunodeficiency (HP:0004430)2.92043825
10Abolished electroretinogram (ERG) (HP:0000550)2.90731512
11Hepatocellular necrosis (HP:0001404)2.86197227
12Type I transferrin isoform profile (HP:0003642)2.84149883
13Hepatic necrosis (HP:0002605)2.83616133
14Mitochondrial inheritance (HP:0001427)2.81222015
15True hermaphroditism (HP:0010459)2.80504011
16Acute encephalopathy (HP:0006846)2.79393848
17Abnormal protein glycosylation (HP:0012346)2.79051008
18Abnormal glycosylation (HP:0012345)2.79051008
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.79051008
20Abnormal protein N-linked glycosylation (HP:0012347)2.79051008
21Nephronophthisis (HP:0000090)2.76310415
22Increased CSF lactate (HP:0002490)2.73842116
23Abnormality of the renal cortex (HP:0011035)2.72625379
24Abnormality of the labia minora (HP:0012880)2.62465171
25Pancreatic fibrosis (HP:0100732)2.61649377
26Thyroiditis (HP:0100646)2.58896796
27Hypothermia (HP:0002045)2.57456364
28Progressive macrocephaly (HP:0004481)2.55509913
29Congenital primary aphakia (HP:0007707)2.53517914
30Abnormal mitochondria in muscle tissue (HP:0008316)2.52889077
31IgG deficiency (HP:0004315)2.52070768
32Gait imbalance (HP:0002141)2.51568225
33Colon cancer (HP:0003003)2.46966183
34Nephrogenic diabetes insipidus (HP:0009806)2.40187916
35Lipid accumulation in hepatocytes (HP:0006561)2.40059488
363-Methylglutaconic aciduria (HP:0003535)2.39862649
37Hyperglycinemia (HP:0002154)2.39401930
38Increased hepatocellular lipid droplets (HP:0006565)2.37922990
39Hypoproteinemia (HP:0003075)2.35522940
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32727903
41Abnormality of alanine metabolism (HP:0010916)2.32727903
42Hyperalaninemia (HP:0003348)2.32727903
43Combined immunodeficiency (HP:0005387)2.31334758
44Cerebral edema (HP:0002181)2.23527770
45Abnormality of the vitamin B12 metabolism (HP:0004341)2.20980176
46Lactic acidosis (HP:0003128)2.20596901
47Attenuation of retinal blood vessels (HP:0007843)2.20356393
48Abnormality of the renal medulla (HP:0100957)2.20090332
49Progressive inability to walk (HP:0002505)2.20051744
50Retinal dysplasia (HP:0007973)2.18220757
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.14399207
52Abnormality of glycine metabolism (HP:0010895)2.13805883
53Abnormality of serine family amino acid metabolism (HP:0010894)2.13805883
54Abnormality of vitamin B metabolism (HP:0004340)2.13638270
55Increased serum lactate (HP:0002151)2.12718053
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12034638
57Abnormality of serum amino acid levels (HP:0003112)2.11911739
58Congenital, generalized hypertrichosis (HP:0004540)2.10637512
59Optic disc pallor (HP:0000543)2.10516182
60Generalized aminoaciduria (HP:0002909)2.07513755
61Meckel diverticulum (HP:0002245)2.07016388
62Abnormality of methionine metabolism (HP:0010901)2.07015444
63Degeneration of anterior horn cells (HP:0002398)2.05181115
64Abnormality of the anterior horn cell (HP:0006802)2.05181115
65Abnormality of the ileum (HP:0001549)2.02535442
66Lissencephaly (HP:0001339)2.01537986
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01213876
68Atrophy/Degeneration involving motor neurons (HP:0007373)1.99495578
69Inability to walk (HP:0002540)1.98857609
70Congenital stationary night blindness (HP:0007642)1.98407188
71Short tibia (HP:0005736)1.98085671
72Lethargy (HP:0001254)1.97925781
73Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97044571
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97044571
75Dicarboxylic aciduria (HP:0003215)1.94753123
76Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94753123
77Postaxial foot polydactyly (HP:0001830)1.94125397
78Hyperglycinuria (HP:0003108)1.94092393
79Genital tract atresia (HP:0001827)1.93997945
80Vaginal atresia (HP:0000148)1.93911422
81Volvulus (HP:0002580)1.91802167
82Ketoacidosis (HP:0001993)1.91668795
83Pendular nystagmus (HP:0012043)1.90169338
84Aplasia/hypoplasia of the uterus (HP:0008684)1.88482013
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.88470389
86Abnormality of chromosome stability (HP:0003220)1.88220529
87Type II lissencephaly (HP:0007260)1.87177304
88Constricted visual fields (HP:0001133)1.85785581
89Adrenal hypoplasia (HP:0000835)1.83263989
90Abnormality of macular pigmentation (HP:0008002)1.82333721
91Hypoglycemic coma (HP:0001325)1.81657470
92Stomatitis (HP:0010280)1.79838995
93Ketosis (HP:0001946)1.79422212
94Sclerocornea (HP:0000647)1.76817902
95Abnormality of B cell number (HP:0010975)1.73769191
96Clubbing of toes (HP:0100760)1.72311399
97Postaxial hand polydactyly (HP:0001162)1.71721798
98Cerebral palsy (HP:0100021)1.71173268
99B lymphocytopenia (HP:0010976)1.70469974
100Amyotrophic lateral sclerosis (HP:0007354)1.69880963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.66603293
2TRIM283.28163683
3ZAK2.92724194
4TXK2.69383363
5NUAK12.60731063
6BCR2.55171538
7WNK32.52595753
8NEK12.52074850
9BCKDK2.50116231
10CSNK1G32.07854464
11SRPK12.00722157
12MST41.95532123
13MKNK11.91276369
14CSNK1A1L1.86264320
15CSNK1G21.85350047
16EIF2AK31.83549486
17CSNK1G11.81273286
18ADRBK21.80514099
19BUB11.79565017
20ERBB31.78548579
21VRK21.77103488
22MAP3K41.73955498
23FRK1.71003883
24PLK41.61252411
25BMPR1B1.56716588
26GRK11.54716508
27VRK11.54144359
28MAP2K71.43080098
29PLK31.38104062
30MAPK131.32489143
31PLK21.31642695
32TSSK61.23712171
33KDR1.18145855
34INSRR1.17302412
35TAOK31.17150377
36TLK11.12408251
37DYRK21.09399657
38FER1.07210223
39OXSR11.03790312
40MKNK21.03784276
41TESK21.02068479
42ACVR1B0.99775043
43PINK10.96355784
44DAPK10.87071860
45MAP3K120.86518976
46PRKCE0.82955461
47RPS6KA40.82405586
48LIMK10.80334244
49EIF2AK20.78800807
50FES0.76883067
51STK390.76860030
52WNK40.72500751
53PAK30.72449310
54MAPKAPK50.71464578
55ATR0.69674133
56FLT30.67699552
57TIE10.65404213
58CDC70.65360945
59STK160.63163507
60MARK10.61322626
61PLK10.60920196
62TAF10.60330166
63EIF2AK10.58301341
64TNIK0.57302458
65SIK30.57119526
66MINK10.56499890
67MUSK0.56011636
68WEE10.54592099
69RPS6KA50.52733000
70TEC0.52658803
71TTK0.52512013
72GRK70.51690290
73BRSK20.49635228
74CSNK1A10.48718247
75GRK60.48004866
76KIT0.47901720
77PBK0.44729971
78ADRBK10.44341568
79IGF1R0.44286208
80GRK50.42878320
81ITK0.42543202
82TESK10.42470533
83PRKCG0.41558256
84AKT30.41503615
85PDK20.41051492
86CSNK2A10.39894252
87CDK190.39589352
88DAPK20.39165072
89CAMK2A0.38869006
90OBSCN0.38421495
91ATM0.34916591
92CAMKK20.34832961
93PRKCQ0.34718502
94NME10.33993682
95TGFBR10.33357537
96PASK0.32885223
97AURKB0.32387703
98STK38L0.31258915
99DYRK30.30331200
100CDK30.29113181

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.92742900
2Protein export_Homo sapiens_hsa030603.44363471
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91481026
4Oxidative phosphorylation_Homo sapiens_hsa001902.33081948
5Non-homologous end-joining_Homo sapiens_hsa034502.26891081
6Propanoate metabolism_Homo sapiens_hsa006402.19436697
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17342692
8RNA polymerase_Homo sapiens_hsa030202.14005084
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11569379
10Parkinsons disease_Homo sapiens_hsa050122.01387536
11Mismatch repair_Homo sapiens_hsa034301.96366782
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95067343
13Fanconi anemia pathway_Homo sapiens_hsa034601.94524896
14Butanoate metabolism_Homo sapiens_hsa006501.90571272
15RNA degradation_Homo sapiens_hsa030181.89581675
16Basal transcription factors_Homo sapiens_hsa030221.86064837
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75509618
18Fatty acid elongation_Homo sapiens_hsa000621.74718002
19Homologous recombination_Homo sapiens_hsa034401.74553072
20Base excision repair_Homo sapiens_hsa034101.69721182
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69416453
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62160038
23Phototransduction_Homo sapiens_hsa047441.57559130
24Steroid biosynthesis_Homo sapiens_hsa001001.49123272
25RNA transport_Homo sapiens_hsa030131.43556790
26DNA replication_Homo sapiens_hsa030301.43449914
27Nucleotide excision repair_Homo sapiens_hsa034201.38347414
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37833057
29Selenocompound metabolism_Homo sapiens_hsa004501.34328361
30Peroxisome_Homo sapiens_hsa041461.31502987
31Primary immunodeficiency_Homo sapiens_hsa053401.22125666
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19604213
33Purine metabolism_Homo sapiens_hsa002301.19290053
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.16686006
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15830758
36Pyrimidine metabolism_Homo sapiens_hsa002401.15209892
37Huntingtons disease_Homo sapiens_hsa050161.14163317
38Regulation of autophagy_Homo sapiens_hsa041401.13792954
39Tryptophan metabolism_Homo sapiens_hsa003801.13442636
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13311636
41Linoleic acid metabolism_Homo sapiens_hsa005911.11213101
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08283519
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08063915
44One carbon pool by folate_Homo sapiens_hsa006701.07318147
45Alzheimers disease_Homo sapiens_hsa050101.06751612
46Spliceosome_Homo sapiens_hsa030401.05808478
47Nitrogen metabolism_Homo sapiens_hsa009101.04308512
48Type I diabetes mellitus_Homo sapiens_hsa049401.03175965
49Sulfur metabolism_Homo sapiens_hsa009201.01405717
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98855851
51Asthma_Homo sapiens_hsa053100.97954518
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93745254
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91376896
54Caffeine metabolism_Homo sapiens_hsa002320.91373566
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89538014
56Nicotine addiction_Homo sapiens_hsa050330.88466658
57Collecting duct acid secretion_Homo sapiens_hsa049660.83828658
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80720670
59Fatty acid metabolism_Homo sapiens_hsa012120.79658852
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78750794
61Allograft rejection_Homo sapiens_hsa053300.76740155
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76548340
63Autoimmune thyroid disease_Homo sapiens_hsa053200.75487210
64Pyruvate metabolism_Homo sapiens_hsa006200.74474577
65Ether lipid metabolism_Homo sapiens_hsa005650.74220902
66Graft-versus-host disease_Homo sapiens_hsa053320.73398595
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72635087
68Taste transduction_Homo sapiens_hsa047420.71556435
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.71353643
70Metabolic pathways_Homo sapiens_hsa011000.70897424
71beta-Alanine metabolism_Homo sapiens_hsa004100.67082563
72Antigen processing and presentation_Homo sapiens_hsa046120.65372857
73Rheumatoid arthritis_Homo sapiens_hsa053230.64258551
74Glutathione metabolism_Homo sapiens_hsa004800.62983471
75Retinol metabolism_Homo sapiens_hsa008300.61832793
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61710207
77Chemical carcinogenesis_Homo sapiens_hsa052040.61552376
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60704176
79GABAergic synapse_Homo sapiens_hsa047270.59689893
80Arachidonic acid metabolism_Homo sapiens_hsa005900.58850203
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57862099
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56023724
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.55742848
84Biosynthesis of amino acids_Homo sapiens_hsa012300.54692776
85Olfactory transduction_Homo sapiens_hsa047400.54058139
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53976200
87Fatty acid degradation_Homo sapiens_hsa000710.53231689
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52948461
89Oocyte meiosis_Homo sapiens_hsa041140.49998448
90Carbon metabolism_Homo sapiens_hsa012000.48535563
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48423278
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.47965113
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46565599
94mRNA surveillance pathway_Homo sapiens_hsa030150.44727332
95N-Glycan biosynthesis_Homo sapiens_hsa005100.43254142
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40296120
97Cardiac muscle contraction_Homo sapiens_hsa042600.39877186
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.39292355
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34792310
100Morphine addiction_Homo sapiens_hsa050320.34749444

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »