

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.04991488 |
| 2 | DNA double-strand break processing (GO:0000729) | 4.84485392 |
| 3 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.14190581 |
| 4 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.14190581 |
| 5 | cullin deneddylation (GO:0010388) | 4.04221857 |
| 6 | protein deneddylation (GO:0000338) | 3.98861136 |
| 7 | protein neddylation (GO:0045116) | 3.82075561 |
| 8 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.80383726 |
| 9 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.80383726 |
| 10 | response to pheromone (GO:0019236) | 3.70523689 |
| 11 | proteasome assembly (GO:0043248) | 3.69080987 |
| 12 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.65143611 |
| 13 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.58723216 |
| 14 | sequestering of actin monomers (GO:0042989) | 3.57947114 |
| 15 | chromatin remodeling at centromere (GO:0031055) | 3.57068233 |
| 16 | platelet dense granule organization (GO:0060155) | 3.54404798 |
| 17 | CENP-A containing nucleosome assembly (GO:0034080) | 3.52155042 |
| 18 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.50457683 |
| 19 | DNA damage response, detection of DNA damage (GO:0042769) | 3.48640276 |
| 20 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.44488110 |
| 21 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.43118747 |
| 22 | ubiquinone metabolic process (GO:0006743) | 3.40320986 |
| 23 | ubiquinone biosynthetic process (GO:0006744) | 3.38893981 |
| 24 | respiratory chain complex IV assembly (GO:0008535) | 3.36349929 |
| 25 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.35587153 |
| 26 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.35198763 |
| 27 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.28911454 |
| 28 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.28911454 |
| 29 | branched-chain amino acid catabolic process (GO:0009083) | 3.23959522 |
| 30 | base-excision repair, AP site formation (GO:0006285) | 3.19340993 |
| 31 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14839693 |
| 32 | protein-cofactor linkage (GO:0018065) | 3.12809628 |
| 33 | histone H2A acetylation (GO:0043968) | 3.11607046 |
| 34 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.09042330 |
| 35 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.07362250 |
| 36 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.06259601 |
| 37 | isotype switching (GO:0045190) | 3.06259601 |
| 38 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.06259601 |
| 39 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.05134580 |
| 40 | mannosylation (GO:0097502) | 3.04638279 |
| 41 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.04262300 |
| 42 | DNA ligation (GO:0006266) | 3.03971345 |
| 43 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.02546269 |
| 44 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.02546269 |
| 45 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.02546269 |
| 46 | cytidine deamination (GO:0009972) | 3.01577228 |
| 47 | cytidine metabolic process (GO:0046087) | 3.01577228 |
| 48 | cytidine catabolic process (GO:0006216) | 3.01577228 |
| 49 | L-methionine salvage (GO:0071267) | 2.95296626 |
| 50 | L-methionine biosynthetic process (GO:0071265) | 2.95296626 |
| 51 | amino acid salvage (GO:0043102) | 2.95296626 |
| 52 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.94520193 |
| 53 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.94520193 |
| 54 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.94506195 |
| 55 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.90399772 |
| 56 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.90252648 |
| 57 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.89255147 |
| 58 | DNA demethylation (GO:0080111) | 2.87354176 |
| 59 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.86728193 |
| 60 | histone exchange (GO:0043486) | 2.84751223 |
| 61 | adenosine metabolic process (GO:0046085) | 2.84096697 |
| 62 | regulation of cilium movement (GO:0003352) | 2.83009496 |
| 63 | GPI anchor metabolic process (GO:0006505) | 2.82920012 |
| 64 | ATP synthesis coupled proton transport (GO:0015986) | 2.81961828 |
| 65 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.81961828 |
| 66 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.80778641 |
| 67 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.80778641 |
| 68 | cytochrome complex assembly (GO:0017004) | 2.77141680 |
| 69 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.76005643 |
| 70 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.76005643 |
| 71 | histone mRNA metabolic process (GO:0008334) | 2.75319021 |
| 72 | positive regulation of protein homodimerization activity (GO:0090073) | 2.74852070 |
| 73 | protein complex biogenesis (GO:0070271) | 2.74462459 |
| 74 | metallo-sulfur cluster assembly (GO:0031163) | 2.73825899 |
| 75 | iron-sulfur cluster assembly (GO:0016226) | 2.73825899 |
| 76 | negative regulation of ligase activity (GO:0051352) | 2.72334016 |
| 77 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.72334016 |
| 78 | quinone biosynthetic process (GO:1901663) | 2.70062995 |
| 79 | GPI anchor biosynthetic process (GO:0006506) | 2.69718132 |
| 80 | L-fucose catabolic process (GO:0042355) | 2.66514350 |
| 81 | fucose catabolic process (GO:0019317) | 2.66514350 |
| 82 | L-fucose metabolic process (GO:0042354) | 2.66514350 |
| 83 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.66194656 |
| 84 | termination of RNA polymerase III transcription (GO:0006386) | 2.66083265 |
| 85 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.66083265 |
| 86 | purine nucleobase biosynthetic process (GO:0009113) | 2.65712554 |
| 87 | mismatch repair (GO:0006298) | 2.65067038 |
| 88 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.64097128 |
| 89 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.64097128 |
| 90 | NADH dehydrogenase complex assembly (GO:0010257) | 2.64097128 |
| 91 | peptidyl-histidine modification (GO:0018202) | 2.64089094 |
| 92 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.63506922 |
| 93 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.60661529 |
| 94 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.60427242 |
| 95 | organelle disassembly (GO:1903008) | 2.59430683 |
| 96 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.58753414 |
| 97 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.57863842 |
| 98 | postreplication repair (GO:0006301) | 2.57820802 |
| 99 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.56717112 |
| 100 | aldehyde catabolic process (GO:0046185) | 2.55894183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.11763321 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.57973110 |
| 3 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.22292207 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.20270259 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.05273278 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.04046953 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.95924344 |
| 8 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.92600036 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.56691070 |
| 10 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.52634149 |
| 11 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.46404371 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.35653041 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.33013088 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.29856983 |
| 15 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.28351393 |
| 16 | EWS_26573619_Chip-Seq_HEK293_Human | 2.24259324 |
| 17 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.19778548 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.13148204 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.03457015 |
| 20 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.03034019 |
| 21 | FUS_26573619_Chip-Seq_HEK293_Human | 1.96057670 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.95619600 |
| 23 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.90192638 |
| 24 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.90094881 |
| 25 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.89766034 |
| 26 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.88609395 |
| 27 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.88132869 |
| 28 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.87939995 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.84815039 |
| 30 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.84399061 |
| 31 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.84053016 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.81206606 |
| 33 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.75647127 |
| 34 | P300_19829295_ChIP-Seq_ESCs_Human | 1.74855688 |
| 35 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.65364607 |
| 36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.60942060 |
| 37 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.59558826 |
| 38 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.58018870 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.56552022 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.55705835 |
| 41 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.46694147 |
| 42 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.44490009 |
| 43 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.42126067 |
| 44 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.39532774 |
| 45 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.37212722 |
| 46 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.36335858 |
| 47 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.36335858 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.36322533 |
| 49 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.35217094 |
| 50 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.34955768 |
| 51 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.30789654 |
| 52 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.30370053 |
| 53 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.30086076 |
| 54 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.29690671 |
| 55 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.28640449 |
| 56 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.28218652 |
| 57 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.28218652 |
| 58 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.28085926 |
| 59 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.26401830 |
| 60 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.24724860 |
| 61 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.23858298 |
| 62 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.20760931 |
| 63 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.18246711 |
| 64 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.18246711 |
| 65 | AR_20517297_ChIP-Seq_VCAP_Human | 1.17954324 |
| 66 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.17371451 |
| 67 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.14073302 |
| 68 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.12748031 |
| 69 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.11654034 |
| 70 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.11534325 |
| 71 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.11228900 |
| 72 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07489304 |
| 73 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.06531289 |
| 74 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.03672058 |
| 75 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.03237453 |
| 76 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.02710540 |
| 77 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.01422874 |
| 78 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.00537504 |
| 79 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.99851657 |
| 80 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.98668063 |
| 81 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.98261074 |
| 82 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.96726201 |
| 83 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.95429285 |
| 84 | NCOR_22424771_ChIP-Seq_293T_Human | 0.95100397 |
| 85 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.94639891 |
| 86 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.94029430 |
| 87 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.93324282 |
| 88 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.92967517 |
| 89 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.92966508 |
| 90 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.92930703 |
| 91 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.92760374 |
| 92 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.91991945 |
| 93 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.91103009 |
| 94 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.90646326 |
| 95 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.89098018 |
| 96 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.89079333 |
| 97 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.88546520 |
| 98 | AR_25329375_ChIP-Seq_VCAP_Human | 0.88450797 |
| 99 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.88080540 |
| 100 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.86799179 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 3.47573811 |
| 2 | MP0008877_abnormal_DNA_methylation | 3.14826851 |
| 3 | MP0006072_abnormal_retinal_apoptosis | 2.80527418 |
| 4 | MP0008058_abnormal_DNA_repair | 2.79762612 |
| 5 | MP0001529_abnormal_vocalization | 2.65204962 |
| 6 | MP0004147_increased_porphyrin_level | 2.52213932 |
| 7 | MP0003786_premature_aging | 2.34666830 |
| 8 | MP0003195_calcinosis | 2.33278659 |
| 9 | MP0001984_abnormal_olfaction | 2.22106721 |
| 10 | MP0009697_abnormal_copulation | 2.11497179 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.09914291 |
| 12 | MP0002736_abnormal_nociception_after | 2.05764939 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.05609157 |
| 14 | MP0008789_abnormal_olfactory_epithelium | 2.05287806 |
| 15 | MP0005253_abnormal_eye_physiology | 1.99902624 |
| 16 | MP0006054_spinal_hemorrhage | 1.99344635 |
| 17 | MP0005084_abnormal_gallbladder_morpholo | 1.91856316 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 1.87297245 |
| 19 | MP0001188_hyperpigmentation | 1.81731534 |
| 20 | MP0005551_abnormal_eye_electrophysiolog | 1.79212919 |
| 21 | MP0003787_abnormal_imprinting | 1.76730207 |
| 22 | MP0003122_maternal_imprinting | 1.76366503 |
| 23 | MP0005499_abnormal_olfactory_system | 1.76186248 |
| 24 | MP0005394_taste/olfaction_phenotype | 1.76186248 |
| 25 | MP0006035_abnormal_mitochondrial_morpho | 1.75521455 |
| 26 | MP0003880_abnormal_central_pattern | 1.74336355 |
| 27 | MP0006036_abnormal_mitochondrial_physio | 1.65656208 |
| 28 | MP0005645_abnormal_hypothalamus_physiol | 1.64919362 |
| 29 | MP0008995_early_reproductive_senescence | 1.64780841 |
| 30 | MP0001764_abnormal_homeostasis | 1.60944838 |
| 31 | MP0003011_delayed_dark_adaptation | 1.60893922 |
| 32 | MP0005671_abnormal_response_to | 1.58838718 |
| 33 | MP0003718_maternal_effect | 1.56589190 |
| 34 | MP0001968_abnormal_touch/_nociception | 1.55687809 |
| 35 | MP0002751_abnormal_autonomic_nervous | 1.55298043 |
| 36 | MP0006276_abnormal_autonomic_nervous | 1.51273898 |
| 37 | MP0008007_abnormal_cellular_replicative | 1.50453532 |
| 38 | MP0003121_genomic_imprinting | 1.49715426 |
| 39 | MP0009046_muscle_twitch | 1.41491538 |
| 40 | MP0004142_abnormal_muscle_tone | 1.39350726 |
| 41 | MP0008872_abnormal_physiological_respon | 1.38525220 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.38461824 |
| 43 | MP0001986_abnormal_taste_sensitivity | 1.34089818 |
| 44 | MP0005075_abnormal_melanosome_morpholog | 1.33090488 |
| 45 | MP0004215_abnormal_myocardial_fiber | 1.31242297 |
| 46 | MP0008875_abnormal_xenobiotic_pharmacok | 1.29610419 |
| 47 | MP0002272_abnormal_nervous_system | 1.24731797 |
| 48 | MP0001905_abnormal_dopamine_level | 1.24412404 |
| 49 | MP0004043_abnormal_pH_regulation | 1.19175870 |
| 50 | MP0002234_abnormal_pharynx_morphology | 1.16372137 |
| 51 | MP0003137_abnormal_impulse_conducting | 1.15633149 |
| 52 | MP0003567_abnormal_fetal_cardiomyocyte | 1.12005144 |
| 53 | MP0004133_heterotaxia | 1.10574499 |
| 54 | MP0004145_abnormal_muscle_electrophysio | 1.09325893 |
| 55 | MP0003119_abnormal_digestive_system | 1.06669023 |
| 56 | MP0003693_abnormal_embryo_hatching | 1.06544489 |
| 57 | MP0006292_abnormal_olfactory_placode | 1.03374309 |
| 58 | MP0002090_abnormal_vision | 1.03307992 |
| 59 | MP0008932_abnormal_embryonic_tissue | 0.98016502 |
| 60 | MP0009745_abnormal_behavioral_response | 0.96633074 |
| 61 | MP0001485_abnormal_pinna_reflex | 0.95642429 |
| 62 | MP0001486_abnormal_startle_reflex | 0.94243188 |
| 63 | MP0005332_abnormal_amino_acid | 0.90728852 |
| 64 | MP0002166_altered_tumor_susceptibility | 0.89906564 |
| 65 | MP0005410_abnormal_fertilization | 0.87910841 |
| 66 | MP0009785_altered_susceptibility_to | 0.87758191 |
| 67 | MP0001501_abnormal_sleep_pattern | 0.87568332 |
| 68 | MP0001835_abnormal_antigen_presentation | 0.86636315 |
| 69 | MP0001929_abnormal_gametogenesis | 0.85498409 |
| 70 | MP0000631_abnormal_neuroendocrine_gland | 0.84996958 |
| 71 | MP0002638_abnormal_pupillary_reflex | 0.84438849 |
| 72 | MP0001293_anophthalmia | 0.84216900 |
| 73 | MP0004957_abnormal_blastocyst_morpholog | 0.84085843 |
| 74 | MP0001177_atelectasis | 0.83816734 |
| 75 | MP0002006_tumorigenesis | 0.83676460 |
| 76 | MP0003646_muscle_fatigue | 0.83385770 |
| 77 | MP0002557_abnormal_social/conspecific_i | 0.79586176 |
| 78 | MP0002572_abnormal_emotion/affect_behav | 0.79443408 |
| 79 | MP0003221_abnormal_cardiomyocyte_apopto | 0.79395965 |
| 80 | MP0010386_abnormal_urinary_bladder | 0.78742376 |
| 81 | MP0003186_abnormal_redox_activity | 0.77845366 |
| 82 | MP0000427_abnormal_hair_cycle | 0.77506697 |
| 83 | MP0000049_abnormal_middle_ear | 0.77122125 |
| 84 | MP0002653_abnormal_ependyma_morphology | 0.76522630 |
| 85 | MP0000647_abnormal_sebaceous_gland | 0.75468961 |
| 86 | MP0004885_abnormal_endolymph | 0.74505519 |
| 87 | MP0003806_abnormal_nucleotide_metabolis | 0.73721477 |
| 88 | MP0008775_abnormal_heart_ventricle | 0.73688175 |
| 89 | MP0002938_white_spotting | 0.73554461 |
| 90 | MP0009764_decreased_sensitivity_to | 0.71256977 |
| 91 | MP0004084_abnormal_cardiac_muscle | 0.70733449 |
| 92 | MP0001119_abnormal_female_reproductive | 0.70663234 |
| 93 | MP0000653_abnormal_sex_gland | 0.69660112 |
| 94 | MP0003937_abnormal_limbs/digits/tail_de | 0.69278031 |
| 95 | MP0002210_abnormal_sex_determination | 0.68585897 |
| 96 | MP0002184_abnormal_innervation | 0.68221503 |
| 97 | MP0002095_abnormal_skin_pigmentation | 0.67850808 |
| 98 | MP0002752_abnormal_somatic_nervous | 0.66948702 |
| 99 | MP0003252_abnormal_bile_duct | 0.66777812 |
| 100 | MP0005389_reproductive_system_phenotype | 0.66045452 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Methylmalonic acidemia (HP:0002912) | 3.73893391 |
| 2 | Renal cortical cysts (HP:0000803) | 3.60994729 |
| 3 | Pancreatic cysts (HP:0001737) | 3.21698439 |
| 4 | Methylmalonic aciduria (HP:0012120) | 3.02664149 |
| 5 | Abnormality of midbrain morphology (HP:0002418) | 2.99497293 |
| 6 | Molar tooth sign on MRI (HP:0002419) | 2.99497293 |
| 7 | Medial flaring of the eyebrow (HP:0010747) | 2.96573282 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 2.96100067 |
| 9 | Severe combined immunodeficiency (HP:0004430) | 2.92043825 |
| 10 | Abolished electroretinogram (ERG) (HP:0000550) | 2.90731512 |
| 11 | Hepatocellular necrosis (HP:0001404) | 2.86197227 |
| 12 | Type I transferrin isoform profile (HP:0003642) | 2.84149883 |
| 13 | Hepatic necrosis (HP:0002605) | 2.83616133 |
| 14 | Mitochondrial inheritance (HP:0001427) | 2.81222015 |
| 15 | True hermaphroditism (HP:0010459) | 2.80504011 |
| 16 | Acute encephalopathy (HP:0006846) | 2.79393848 |
| 17 | Abnormal protein glycosylation (HP:0012346) | 2.79051008 |
| 18 | Abnormal glycosylation (HP:0012345) | 2.79051008 |
| 19 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.79051008 |
| 20 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.79051008 |
| 21 | Nephronophthisis (HP:0000090) | 2.76310415 |
| 22 | Increased CSF lactate (HP:0002490) | 2.73842116 |
| 23 | Abnormality of the renal cortex (HP:0011035) | 2.72625379 |
| 24 | Abnormality of the labia minora (HP:0012880) | 2.62465171 |
| 25 | Pancreatic fibrosis (HP:0100732) | 2.61649377 |
| 26 | Thyroiditis (HP:0100646) | 2.58896796 |
| 27 | Hypothermia (HP:0002045) | 2.57456364 |
| 28 | Progressive macrocephaly (HP:0004481) | 2.55509913 |
| 29 | Congenital primary aphakia (HP:0007707) | 2.53517914 |
| 30 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.52889077 |
| 31 | IgG deficiency (HP:0004315) | 2.52070768 |
| 32 | Gait imbalance (HP:0002141) | 2.51568225 |
| 33 | Colon cancer (HP:0003003) | 2.46966183 |
| 34 | Nephrogenic diabetes insipidus (HP:0009806) | 2.40187916 |
| 35 | Lipid accumulation in hepatocytes (HP:0006561) | 2.40059488 |
| 36 | 3-Methylglutaconic aciduria (HP:0003535) | 2.39862649 |
| 37 | Hyperglycinemia (HP:0002154) | 2.39401930 |
| 38 | Increased hepatocellular lipid droplets (HP:0006565) | 2.37922990 |
| 39 | Hypoproteinemia (HP:0003075) | 2.35522940 |
| 40 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.32727903 |
| 41 | Abnormality of alanine metabolism (HP:0010916) | 2.32727903 |
| 42 | Hyperalaninemia (HP:0003348) | 2.32727903 |
| 43 | Combined immunodeficiency (HP:0005387) | 2.31334758 |
| 44 | Cerebral edema (HP:0002181) | 2.23527770 |
| 45 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.20980176 |
| 46 | Lactic acidosis (HP:0003128) | 2.20596901 |
| 47 | Attenuation of retinal blood vessels (HP:0007843) | 2.20356393 |
| 48 | Abnormality of the renal medulla (HP:0100957) | 2.20090332 |
| 49 | Progressive inability to walk (HP:0002505) | 2.20051744 |
| 50 | Retinal dysplasia (HP:0007973) | 2.18220757 |
| 51 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.14399207 |
| 52 | Abnormality of glycine metabolism (HP:0010895) | 2.13805883 |
| 53 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.13805883 |
| 54 | Abnormality of vitamin B metabolism (HP:0004340) | 2.13638270 |
| 55 | Increased serum lactate (HP:0002151) | 2.12718053 |
| 56 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.12034638 |
| 57 | Abnormality of serum amino acid levels (HP:0003112) | 2.11911739 |
| 58 | Congenital, generalized hypertrichosis (HP:0004540) | 2.10637512 |
| 59 | Optic disc pallor (HP:0000543) | 2.10516182 |
| 60 | Generalized aminoaciduria (HP:0002909) | 2.07513755 |
| 61 | Meckel diverticulum (HP:0002245) | 2.07016388 |
| 62 | Abnormality of methionine metabolism (HP:0010901) | 2.07015444 |
| 63 | Degeneration of anterior horn cells (HP:0002398) | 2.05181115 |
| 64 | Abnormality of the anterior horn cell (HP:0006802) | 2.05181115 |
| 65 | Abnormality of the ileum (HP:0001549) | 2.02535442 |
| 66 | Lissencephaly (HP:0001339) | 2.01537986 |
| 67 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.01213876 |
| 68 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.99495578 |
| 69 | Inability to walk (HP:0002540) | 1.98857609 |
| 70 | Congenital stationary night blindness (HP:0007642) | 1.98407188 |
| 71 | Short tibia (HP:0005736) | 1.98085671 |
| 72 | Lethargy (HP:0001254) | 1.97925781 |
| 73 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.97044571 |
| 74 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.97044571 |
| 75 | Dicarboxylic aciduria (HP:0003215) | 1.94753123 |
| 76 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.94753123 |
| 77 | Postaxial foot polydactyly (HP:0001830) | 1.94125397 |
| 78 | Hyperglycinuria (HP:0003108) | 1.94092393 |
| 79 | Genital tract atresia (HP:0001827) | 1.93997945 |
| 80 | Vaginal atresia (HP:0000148) | 1.93911422 |
| 81 | Volvulus (HP:0002580) | 1.91802167 |
| 82 | Ketoacidosis (HP:0001993) | 1.91668795 |
| 83 | Pendular nystagmus (HP:0012043) | 1.90169338 |
| 84 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.88482013 |
| 85 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.88470389 |
| 86 | Abnormality of chromosome stability (HP:0003220) | 1.88220529 |
| 87 | Type II lissencephaly (HP:0007260) | 1.87177304 |
| 88 | Constricted visual fields (HP:0001133) | 1.85785581 |
| 89 | Adrenal hypoplasia (HP:0000835) | 1.83263989 |
| 90 | Abnormality of macular pigmentation (HP:0008002) | 1.82333721 |
| 91 | Hypoglycemic coma (HP:0001325) | 1.81657470 |
| 92 | Stomatitis (HP:0010280) | 1.79838995 |
| 93 | Ketosis (HP:0001946) | 1.79422212 |
| 94 | Sclerocornea (HP:0000647) | 1.76817902 |
| 95 | Abnormality of B cell number (HP:0010975) | 1.73769191 |
| 96 | Clubbing of toes (HP:0100760) | 1.72311399 |
| 97 | Postaxial hand polydactyly (HP:0001162) | 1.71721798 |
| 98 | Cerebral palsy (HP:0100021) | 1.71173268 |
| 99 | B lymphocytopenia (HP:0010976) | 1.70469974 |
| 100 | Amyotrophic lateral sclerosis (HP:0007354) | 1.69880963 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K2 | 3.66603293 |
| 2 | TRIM28 | 3.28163683 |
| 3 | ZAK | 2.92724194 |
| 4 | TXK | 2.69383363 |
| 5 | NUAK1 | 2.60731063 |
| 6 | BCR | 2.55171538 |
| 7 | WNK3 | 2.52595753 |
| 8 | NEK1 | 2.52074850 |
| 9 | BCKDK | 2.50116231 |
| 10 | CSNK1G3 | 2.07854464 |
| 11 | SRPK1 | 2.00722157 |
| 12 | MST4 | 1.95532123 |
| 13 | MKNK1 | 1.91276369 |
| 14 | CSNK1A1L | 1.86264320 |
| 15 | CSNK1G2 | 1.85350047 |
| 16 | EIF2AK3 | 1.83549486 |
| 17 | CSNK1G1 | 1.81273286 |
| 18 | ADRBK2 | 1.80514099 |
| 19 | BUB1 | 1.79565017 |
| 20 | ERBB3 | 1.78548579 |
| 21 | VRK2 | 1.77103488 |
| 22 | MAP3K4 | 1.73955498 |
| 23 | FRK | 1.71003883 |
| 24 | PLK4 | 1.61252411 |
| 25 | BMPR1B | 1.56716588 |
| 26 | GRK1 | 1.54716508 |
| 27 | VRK1 | 1.54144359 |
| 28 | MAP2K7 | 1.43080098 |
| 29 | PLK3 | 1.38104062 |
| 30 | MAPK13 | 1.32489143 |
| 31 | PLK2 | 1.31642695 |
| 32 | TSSK6 | 1.23712171 |
| 33 | KDR | 1.18145855 |
| 34 | INSRR | 1.17302412 |
| 35 | TAOK3 | 1.17150377 |
| 36 | TLK1 | 1.12408251 |
| 37 | DYRK2 | 1.09399657 |
| 38 | FER | 1.07210223 |
| 39 | OXSR1 | 1.03790312 |
| 40 | MKNK2 | 1.03784276 |
| 41 | TESK2 | 1.02068479 |
| 42 | ACVR1B | 0.99775043 |
| 43 | PINK1 | 0.96355784 |
| 44 | DAPK1 | 0.87071860 |
| 45 | MAP3K12 | 0.86518976 |
| 46 | PRKCE | 0.82955461 |
| 47 | RPS6KA4 | 0.82405586 |
| 48 | LIMK1 | 0.80334244 |
| 49 | EIF2AK2 | 0.78800807 |
| 50 | FES | 0.76883067 |
| 51 | STK39 | 0.76860030 |
| 52 | WNK4 | 0.72500751 |
| 53 | PAK3 | 0.72449310 |
| 54 | MAPKAPK5 | 0.71464578 |
| 55 | ATR | 0.69674133 |
| 56 | FLT3 | 0.67699552 |
| 57 | TIE1 | 0.65404213 |
| 58 | CDC7 | 0.65360945 |
| 59 | STK16 | 0.63163507 |
| 60 | MARK1 | 0.61322626 |
| 61 | PLK1 | 0.60920196 |
| 62 | TAF1 | 0.60330166 |
| 63 | EIF2AK1 | 0.58301341 |
| 64 | TNIK | 0.57302458 |
| 65 | SIK3 | 0.57119526 |
| 66 | MINK1 | 0.56499890 |
| 67 | MUSK | 0.56011636 |
| 68 | WEE1 | 0.54592099 |
| 69 | RPS6KA5 | 0.52733000 |
| 70 | TEC | 0.52658803 |
| 71 | TTK | 0.52512013 |
| 72 | GRK7 | 0.51690290 |
| 73 | BRSK2 | 0.49635228 |
| 74 | CSNK1A1 | 0.48718247 |
| 75 | GRK6 | 0.48004866 |
| 76 | KIT | 0.47901720 |
| 77 | PBK | 0.44729971 |
| 78 | ADRBK1 | 0.44341568 |
| 79 | IGF1R | 0.44286208 |
| 80 | GRK5 | 0.42878320 |
| 81 | ITK | 0.42543202 |
| 82 | TESK1 | 0.42470533 |
| 83 | PRKCG | 0.41558256 |
| 84 | AKT3 | 0.41503615 |
| 85 | PDK2 | 0.41051492 |
| 86 | CSNK2A1 | 0.39894252 |
| 87 | CDK19 | 0.39589352 |
| 88 | DAPK2 | 0.39165072 |
| 89 | CAMK2A | 0.38869006 |
| 90 | OBSCN | 0.38421495 |
| 91 | ATM | 0.34916591 |
| 92 | CAMKK2 | 0.34832961 |
| 93 | PRKCQ | 0.34718502 |
| 94 | NME1 | 0.33993682 |
| 95 | TGFBR1 | 0.33357537 |
| 96 | PASK | 0.32885223 |
| 97 | AURKB | 0.32387703 |
| 98 | STK38L | 0.31258915 |
| 99 | DYRK3 | 0.30331200 |
| 100 | CDK3 | 0.29113181 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.92742900 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.44363471 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.91481026 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.33081948 |
| 5 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.26891081 |
| 6 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.19436697 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.17342692 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.14005084 |
| 9 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.11569379 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.01387536 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 1.96366782 |
| 12 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.95067343 |
| 13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.94524896 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.90571272 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 1.89581675 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.86064837 |
| 17 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.75509618 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.74718002 |
| 19 | Homologous recombination_Homo sapiens_hsa03440 | 1.74553072 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.69721182 |
| 21 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.69416453 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.62160038 |
| 23 | Phototransduction_Homo sapiens_hsa04744 | 1.57559130 |
| 24 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.49123272 |
| 25 | RNA transport_Homo sapiens_hsa03013 | 1.43556790 |
| 26 | DNA replication_Homo sapiens_hsa03030 | 1.43449914 |
| 27 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.38347414 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.37833057 |
| 29 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.34328361 |
| 30 | Peroxisome_Homo sapiens_hsa04146 | 1.31502987 |
| 31 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.22125666 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.19604213 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.19290053 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.16686006 |
| 35 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.15830758 |
| 36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.15209892 |
| 37 | Huntingtons disease_Homo sapiens_hsa05016 | 1.14163317 |
| 38 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.13792954 |
| 39 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.13442636 |
| 40 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.13311636 |
| 41 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.11213101 |
| 42 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.08283519 |
| 43 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.08063915 |
| 44 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.07318147 |
| 45 | Alzheimers disease_Homo sapiens_hsa05010 | 1.06751612 |
| 46 | Spliceosome_Homo sapiens_hsa03040 | 1.05808478 |
| 47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.04308512 |
| 48 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.03175965 |
| 49 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.01405717 |
| 50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.98855851 |
| 51 | Asthma_Homo sapiens_hsa05310 | 0.97954518 |
| 52 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93745254 |
| 53 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.91376896 |
| 54 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.91373566 |
| 55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.89538014 |
| 56 | Nicotine addiction_Homo sapiens_hsa05033 | 0.88466658 |
| 57 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.83828658 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80720670 |
| 59 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.79658852 |
| 60 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.78750794 |
| 61 | Allograft rejection_Homo sapiens_hsa05330 | 0.76740155 |
| 62 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.76548340 |
| 63 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.75487210 |
| 64 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.74474577 |
| 65 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.74220902 |
| 66 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.73398595 |
| 67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.72635087 |
| 68 | Taste transduction_Homo sapiens_hsa04742 | 0.71556435 |
| 69 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.71353643 |
| 70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.70897424 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.67082563 |
| 72 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.65372857 |
| 73 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.64258551 |
| 74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.62983471 |
| 75 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61832793 |
| 76 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.61710207 |
| 77 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.61552376 |
| 78 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.60704176 |
| 79 | GABAergic synapse_Homo sapiens_hsa04727 | 0.59689893 |
| 80 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.58850203 |
| 81 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.57862099 |
| 82 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.56023724 |
| 83 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.55742848 |
| 84 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.54692776 |
| 85 | Olfactory transduction_Homo sapiens_hsa04740 | 0.54058139 |
| 86 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.53976200 |
| 87 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.53231689 |
| 88 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.52948461 |
| 89 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.49998448 |
| 90 | Carbon metabolism_Homo sapiens_hsa01200 | 0.48535563 |
| 91 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.48423278 |
| 92 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.47965113 |
| 93 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46565599 |
| 94 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.44727332 |
| 95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43254142 |
| 96 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.40296120 |
| 97 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.39877186 |
| 98 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.39292355 |
| 99 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.34792310 |
| 100 | Morphine addiction_Homo sapiens_hsa05032 | 0.34749444 |

