ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of natural killer cell differentiation (GO:0032825)	4.91282074
2	muscle atrophy (GO:0014889)	4.83013352
3	cellular response to interleukin-15 (GO:0071350)	4.63366253
4	striated muscle atrophy (GO:0014891)	4.62780595
5	skeletal muscle adaptation (GO:0043501)	4.46638956
6	regulation of germinal center formation (GO:0002634)	4.23037413
7	L-fucose catabolic process (GO:0042355)	4.13409156
8	fucose catabolic process (GO:0019317)	4.13409156
9	L-fucose metabolic process (GO:0042354)	4.13409156
10	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.08507024
11	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.01803435
12	DNA double-strand break processing (GO:0000729)	3.88392868
13	protein polyglutamylation (GO:0018095)	3.86638394
14	response to interleukin-15 (GO:0070672)	3.76398732
15	response to xenobiotic stimulus (GO:0009410)	3.74418795
16	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.63763506
17	regulation of skeletal muscle contraction (GO:0014819)	3.56847810
18	sulfation (GO:0051923)	3.55919553
19	interferon-gamma production (GO:0032609)	3.51100332
20	adaptation of signaling pathway (GO:0023058)	3.46061577
21	lymph node development (GO:0048535)	3.36121151
22	DNA demethylation (GO:0080111)	3.35211883
23	cytidine metabolic process (GO:0046087)	3.34707295
24	cytidine catabolic process (GO:0006216)	3.34707295
25	cytidine deamination (GO:0009972)	3.34707295
26	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.31922322
27	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.31773161
28	regulation of sarcomere organization (GO:0060297)	3.26930221
29	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.26901240
30	activated T cell proliferation (GO:0050798)	3.26580697
31	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.25663051
32	response to pheromone (GO:0019236)	3.25249437
33	tryptophan metabolic process (GO:0006568)	3.23436601
34	natural killer cell differentiation (GO:0001779)	3.22664008
35	regulation of DNA endoreduplication (GO:0032875)	3.19833543
36	multicellular organism reproduction (GO:0032504)	3.18454915
37	negative regulation by host of viral transcription (GO:0043922)	3.18054222
38	positive regulation of defense response to virus by host (GO:0002230)	3.14715112
39	DNA dealkylation (GO:0035510)	3.12686551
40	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.06313764
41	neural tube formation (GO:0001841)	3.04106894
42	heme transport (GO:0015886)	3.01253107
43	regulation of natural killer cell differentiation (GO:0032823)	2.97692445
44	hepatocyte apoptotic process (GO:0097284)	2.96742948
45	natural killer cell activation (GO:0030101)	2.96658675
46	regulation of fibroblast apoptotic process (GO:2000269)	2.96357551
47	regulation of B cell receptor signaling pathway (GO:0050855)	2.94452448
48	DNA deamination (GO:0045006)	2.93642096
49	positive regulation of T cell chemotaxis (GO:0010820)	2.93445527
50	regulation of T cell chemotaxis (GO:0010819)	2.93445527
51	positive regulation of macrophage differentiation (GO:0045651)	2.91483497
52	T cell migration (GO:0072678)	2.88734224
53	dentate gyrus development (GO:0021542)	2.88376609
54	positive regulation of natural killer cell activation (GO:0032816)	2.87264700
55	protein K63-linked deubiquitination (GO:0070536)	2.82645920
56	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.77470729
57	positive regulation of developmental pigmentation (GO:0048087)	2.77406569
58	regulation of hippo signaling (GO:0035330)	2.74195501
59	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.73836684
60	regulation of T cell mediated cytotoxicity (GO:0001914)	2.72831276
61	regulation of defense response to virus by host (GO:0050691)	2.72296977
62	phospholipid translocation (GO:0045332)	2.72066868
63	lipid translocation (GO:0034204)	2.72066868
64	cellular response to ethanol (GO:0071361)	2.71805752
65	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.65556616
66	protein K11-linked deubiquitination (GO:0035871)	2.65187365
67	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.64939217
68	establishment of protein localization to Golgi (GO:0072600)	2.63872653
69	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.61457081
70	indolalkylamine metabolic process (GO:0006586)	2.60332964
71	arginine catabolic process (GO:0006527)	2.59973937
72	regulation of natural killer cell activation (GO:0032814)	2.59302999
73	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.57789961
74	negative regulation of cell killing (GO:0031342)	2.57789961
75	positive regulation of interleukin-17 production (GO:0032740)	2.57210587
76	synapsis (GO:0007129)	2.55060557
77	negative regulation of T cell apoptotic process (GO:0070233)	2.53732343
78	indole-containing compound catabolic process (GO:0042436)	2.53483556
79	indolalkylamine catabolic process (GO:0046218)	2.53483556
80	tryptophan catabolic process (GO:0006569)	2.53483556
81	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.52784317
82	protein targeting to Golgi (GO:0000042)	2.50207997
83	histone H2A acetylation (GO:0043968)	2.49937705
84	replication fork processing (GO:0031297)	2.48741988
85	B cell homeostasis (GO:0001782)	2.45053099
86	regulation of regulatory T cell differentiation (GO:0045589)	2.45048628
87	negative T cell selection (GO:0043383)	2.43630577
88	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.42536941
89	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.42099366
90	T cell mediated immunity (GO:0002456)	2.41279698
91	preassembly of GPI anchor in ER membrane (GO:0016254)	2.39525085
92	regulation of alpha-beta T cell proliferation (GO:0046640)	2.38462625
93	protein K48-linked deubiquitination (GO:0071108)	2.38178139
94	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.38132512
95	negative regulation of cAMP-mediated signaling (GO:0043951)	2.35470548
96	negative regulation of DNA binding (GO:0043392)	2.35247207
97	negative regulation of execution phase of apoptosis (GO:1900118)	2.34290338
98	auditory receptor cell differentiation (GO:0042491)	2.34142629
99	T cell proliferation (GO:0042098)	2.34048718
100	poly(A)+ mRNA export from nucleus (GO:0016973)	2.33029710

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.21810260
2	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	4.15306656
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.84453784
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.77755912
5	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.46198698
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.35955700
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.76728024
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76079518
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.68808196
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.62988016
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48612511
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28393016
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.20316416
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12371027
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.11133189
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06723550
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01458190
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94574928
19	EWS_26573619_Chip-Seq_HEK293_Human	1.92976312
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.85620755
21	P300_19829295_ChIP-Seq_ESCs_Human	1.80884012
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.78162064
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73326614
24	FUS_26573619_Chip-Seq_HEK293_Human	1.64967094
25	RUNX_20019798_ChIP-Seq_JUKART_Human	1.63506703
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63501750
27	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.63295760
28	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.60625835
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58861756
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56263451
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.54885734
32	CDX2_22108803_ChIP-Seq_LS180_Human	1.53532427
33	STAT3_23295773_ChIP-Seq_U87_Human	1.48961570
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47753489
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44651367
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42077162
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42077162
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41714687
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.41714687
40	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.37219618
41	RXR_22108803_ChIP-Seq_LS180_Human	1.36685721
42	MYB_26560356_Chip-Seq_TH2_Human	1.35584156
43	VDR_24787735_ChIP-Seq_THP-1_Human	1.32615177
44	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32603380
45	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.31893741
46	GATA3_27048872_Chip-Seq_THYMUS_Human	1.30711595
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.29176828
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28833722
49	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.27054017
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26847649
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26802272
52	GATA3_26560356_Chip-Seq_TH2_Human	1.26733468
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.25811468
54	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.25076684
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23760172
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22883310
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.20756402
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18959949
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18293447
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17614945
61	VDR_22108803_ChIP-Seq_LS180_Human	1.17193134
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.17186547
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16384183
64	AHR_22903824_ChIP-Seq_MCF-7_Human	1.15952043
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15899320
66	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.15845695
67	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13358329
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13324174
69	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.13171840
70	TCF4_23295773_ChIP-Seq_U87_Human	1.12805192
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10091265
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.09795772
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09560567
74	MYB_26560356_Chip-Seq_TH1_Human	1.07973928
75	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.07288332
76	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.07017934
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06127720
78	TP53_16413492_ChIP-PET_HCT116_Human	1.06098306
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04080908
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03142614
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02659358
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02328154
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00283751
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99713511
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99713511
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99410154
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.98003334
88	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.97978070
89	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.97841109
90	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.97455721
91	AR_25329375_ChIP-Seq_VCAP_Human	0.96282395
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96007952
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95924042
94	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95399402
95	GATA3_26560356_Chip-Seq_TH1_Human	0.94532314
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94376045
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91682216
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89912111
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88406834
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.87360736

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.33946206
2	MP0000569_abnormal_digit_pigmentation	3.29392025
3	MP0003656_abnormal_erythrocyte_physiolo	3.21421958
4	MP0006072_abnormal_retinal_apoptosis	3.18120225
5	MP0000372_irregular_coat_pigmentation	3.09674884
6	MP0008995_early_reproductive_senescence	2.82008106
7	MP0002138_abnormal_hepatobiliary_system	2.79976624
8	MP0004381_abnormal_hair_follicle	2.69714999
9	MP0003136_yellow_coat_color	2.66554713
10	MP0005671_abnormal_response_to	2.59401273
11	MP0003786_premature_aging	2.50118636
12	MP0003763_abnormal_thymus_physiology	2.05058161
13	MP0000465_gastrointestinal_hemorrhage	1.98807512
14	MP0008057_abnormal_DNA_replication	1.89564000
15	MP0005253_abnormal_eye_physiology	1.85978313
16	MP0005171_absent_coat_pigmentation	1.83656476
17	MP0006054_spinal_hemorrhage	1.78659254
18	MP0000685_abnormal_immune_system	1.77358673
19	MP0009697_abnormal_copulation	1.75750405
20	MP0003045_fibrosis	1.71346051
21	MP0005389_reproductive_system_phenotype	1.66644077
22	MP0005075_abnormal_melanosome_morpholog	1.65350332
23	MP0001529_abnormal_vocalization	1.63376584
24	MP0001835_abnormal_antigen_presentation	1.62225079
25	MP0003724_increased_susceptibility_to	1.62136009
26	MP0005377_hearing/vestibular/ear_phenot	1.60616672
27	MP0003878_abnormal_ear_physiology	1.60616672
28	MP0002160_abnormal_reproductive_system	1.52203993
29	MP0002095_abnormal_skin_pigmentation	1.51037791
30	MP0008789_abnormal_olfactory_epithelium	1.50007872
31	MP0000749_muscle_degeneration	1.46456373
32	MP0001800_abnormal_humoral_immune	1.43306102
33	MP0004145_abnormal_muscle_electrophysio	1.41359152
34	MP0005551_abnormal_eye_electrophysiolog	1.40857307
35	MP0002405_respiratory_system_inflammati	1.37555529
36	MP0001485_abnormal_pinna_reflex	1.35668020
37	MP0001919_abnormal_reproductive_system	1.35543516
38	MP0001188_hyperpigmentation	1.35390656
39	MP0001879_abnormal_lymphatic_vessel	1.34362806
40	MP0002638_abnormal_pupillary_reflex	1.30058393
41	MP0003195_calcinosis	1.28621087
42	MP0009785_altered_susceptibility_to	1.28602418
43	MP0005310_abnormal_salivary_gland	1.26271224
44	MP0000613_abnormal_salivary_gland	1.25699364
45	MP0004484_altered_response_of	1.23152542
46	MP0000703_abnormal_thymus_morphology	1.21082444
47	MP0002090_abnormal_vision	1.19826027
48	MP0002722_abnormal_immune_system	1.19400095
49	MP0000689_abnormal_spleen_morphology	1.12879022
50	MP0003252_abnormal_bile_duct	1.10942008
51	MP0000427_abnormal_hair_cycle	1.09180106
52	MP0001502_abnormal_circadian_rhythm	1.09155978
53	MP0003221_abnormal_cardiomyocyte_apopto	1.08845442
54	MP0008961_abnormal_basal_metabolism	1.07912389
55	MP0001984_abnormal_olfaction	1.07855976
56	MP0002420_abnormal_adaptive_immunity	1.07580152
57	MP0001819_abnormal_immune_cell	1.07429539
58	MP0003646_muscle_fatigue	1.03363441
59	MP0002127_abnormal_cardiovascular_syste	1.02416972
60	MP0002168_other_aberrant_phenotype	1.01544989
61	MP0000049_abnormal_middle_ear	1.00621016
62	MP0002723_abnormal_immune_serum	1.00126915
63	MP0005499_abnormal_olfactory_system	0.99988078
64	MP0005394_taste/olfaction_phenotype	0.99988078
65	MP0002398_abnormal_bone_marrow	0.97295043
66	MP0002148_abnormal_hypersensitivity_rea	0.97171509
67	MP0010386_abnormal_urinary_bladder	0.95325369
68	MP0002269_muscular_atrophy	0.95151464
69	MP0002452_abnormal_antigen_presenting	0.93928415
70	MP0005000_abnormal_immune_tolerance	0.93725676
71	MP0004134_abnormal_chest_morphology	0.93717106
72	MP0001346_abnormal_lacrimal_gland	0.92019740
73	MP0009765_abnormal_xenobiotic_induced	0.91150330
74	MP0008877_abnormal_DNA_methylation	0.89729563
75	MP0010368_abnormal_lymphatic_system	0.89323350
76	MP0000747_muscle_weakness	0.87543803
77	MP0003011_delayed_dark_adaptation	0.86882882
78	MP0005025_abnormal_response_to	0.86178305
79	MP0002837_dystrophic_cardiac_calcinosis	0.85570650
80	MP0005174_abnormal_tail_pigmentation	0.84882349
81	MP0000716_abnormal_immune_system	0.83904086
82	MP0000371_diluted_coat_color	0.83555714
83	MP0002876_abnormal_thyroid_physiology	0.80753542
84	MP0003890_abnormal_embryonic-extraembry	0.80291947
85	MP0002102_abnormal_ear_morphology	0.79347262
86	MP0001873_stomach_inflammation	0.78581078
87	MP0002332_abnormal_exercise_endurance	0.78134135
88	MP0004084_abnormal_cardiac_muscle	0.77587775
89	MP0005387_immune_system_phenotype	0.75713134
90	MP0001790_abnormal_immune_system	0.75713134
91	MP0004215_abnormal_myocardial_fiber	0.73709047
92	MP0005391_vision/eye_phenotype	0.73692582
93	MP0005084_abnormal_gallbladder_morpholo	0.70290833
94	MP0003937_abnormal_limbs/digits/tail_de	0.70111266
95	MP0002419_abnormal_innate_immunity	0.70042516
96	MP0002163_abnormal_gland_morphology	0.68910756
97	MP0005647_abnormal_sex_gland	0.68577339
98	MP0004036_abnormal_muscle_relaxation	0.67255582
99	MP0005187_abnormal_penis_morphology	0.67131007
100	MP0005083_abnormal_biliary_tract	0.67123215

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroiditis (HP:0100646)	4.18831865
2	Mesomelia (HP:0003027)	4.07006458
3	Conjunctival hamartoma (HP:0100780)	3.91867870
4	Severe combined immunodeficiency (HP:0004430)	3.75585697
5	T lymphocytopenia (HP:0005403)	3.66762513
6	Fibular aplasia (HP:0002990)	3.62746277
7	Abnormality of T cell number (HP:0011839)	3.48059112
8	IgG deficiency (HP:0004315)	3.32511731
9	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.28138316
10	Short tibia (HP:0005736)	3.24925850
11	Hamartoma of the eye (HP:0010568)	3.20356769
12	Chronic diarrhea (HP:0002028)	3.19130211
13	Renal cortical cysts (HP:0000803)	3.17285965
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.04981714
15	Abnormality of the columella (HP:0009929)	3.04528776
16	Abnormality of eosinophils (HP:0001879)	3.01688524
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.99806317
18	Combined immunodeficiency (HP:0005387)	2.85497035
19	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.79849310
20	Volvulus (HP:0002580)	2.77490879
21	Nephronophthisis (HP:0000090)	2.76639880
22	Stomach cancer (HP:0012126)	2.71580778
23	Pendular nystagmus (HP:0012043)	2.66667327
24	Abolished electroretinogram (ERG) (HP:0000550)	2.62305700
25	Submucous cleft hard palate (HP:0000176)	2.61409364
26	Meningioma (HP:0002858)	2.55864554
27	Small hand (HP:0200055)	2.55646881
28	Pancreatic cysts (HP:0001737)	2.53747681
29	Abnormality of the renal cortex (HP:0011035)	2.53623069
30	Subacute progressive viral hepatitis (HP:0006572)	2.52241153
31	Median cleft lip (HP:0000161)	2.50100702
32	Furrowed tongue (HP:0000221)	2.38940614
33	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.35708178
34	Cavernous hemangioma (HP:0001048)	2.33361775
35	Hypoplasia of the thymus (HP:0000778)	2.33018048
36	Constricted visual fields (HP:0001133)	2.32185412
37	Asplenia (HP:0001746)	2.31911312
38	Persistence of primary teeth (HP:0006335)	2.31245980
39	Abnormality of T cells (HP:0002843)	2.28633185
40	Intestinal atresia (HP:0011100)	2.24073937
41	Abnormality of the renal medulla (HP:0100957)	2.23904386
42	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.23534330
43	Chronic mucocutaneous candidiasis (HP:0002728)	2.23272627
44	Recurrent cutaneous fungal infections (HP:0011370)	2.23272627
45	Stomatitis (HP:0010280)	2.21706127
46	Angiofibromas (HP:0010615)	2.21396073
47	Adenoma sebaceum (HP:0009720)	2.21396073
48	Sensory axonal neuropathy (HP:0003390)	2.20052159
49	Anhidrosis (HP:0000970)	2.11633095
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.10820944
51	Attenuation of retinal blood vessels (HP:0007843)	2.10145928
52	Reduced antithrombin III activity (HP:0001976)	2.06969843
53	Congenital stationary night blindness (HP:0007642)	2.03994044
54	Abnormality of lateral ventricle (HP:0030047)	2.03711608
55	Conjugated hyperbilirubinemia (HP:0002908)	2.02628912
56	Molar tooth sign on MRI (HP:0002419)	2.02220350
57	Abnormality of midbrain morphology (HP:0002418)	2.02220350
58	Leukocytosis (HP:0001974)	2.02203629
59	Clubbing of toes (HP:0100760)	1.99688355
60	Pancreatic fibrosis (HP:0100732)	1.99407438
61	True hermaphroditism (HP:0010459)	1.99266169
62	Widely spaced teeth (HP:0000687)	1.96688836
63	Abnormal protein glycosylation (HP:0012346)	1.96090903
64	Abnormal glycosylation (HP:0012345)	1.96090903
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.96090903
66	Abnormal protein N-linked glycosylation (HP:0012347)	1.96090903
67	Adrenal hypoplasia (HP:0000835)	1.95607292
68	Cupped ear (HP:0000378)	1.95484746
69	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.92549564
70	Hematochezia (HP:0002573)	1.92532093
71	Eosinophilia (HP:0001880)	1.90883279
72	2-3 toe syndactyly (HP:0004691)	1.90656375
73	Clumsiness (HP:0002312)	1.90242070
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88842718
75	Abnormality of the frontal sinuses (HP:0002687)	1.88210815
76	Neonatal respiratory distress (HP:0002643)	1.86320297
77	Bone cyst (HP:0012062)	1.85211551
78	Adactyly (HP:0009776)	1.84956551
79	Benign neoplasm of the central nervous system (HP:0100835)	1.83913081
80	Coxa valga (HP:0002673)	1.83395408
81	Paralysis (HP:0003470)	1.82854438
82	Abnormality of chromosome stability (HP:0003220)	1.82358948
83	IgA deficiency (HP:0002720)	1.81782590
84	Type I transferrin isoform profile (HP:0003642)	1.81362785
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80283881
86	Hypothermia (HP:0002045)	1.79269064
87	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79225295
88	Absent speech (HP:0001344)	1.78928052
89	Melanoma (HP:0002861)	1.74583939
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74442232
91	Hypoplasia of the uterus (HP:0000013)	1.74249223
92	Anencephaly (HP:0002323)	1.71973952
93	Ovarian neoplasm (HP:0100615)	1.71927431
94	Protruding tongue (HP:0010808)	1.70107513
95	Duplicated collecting system (HP:0000081)	1.69904679
96	Abnormality of DNA repair (HP:0003254)	1.69766534
97	Abnormality of the renal collecting system (HP:0004742)	1.69147933
98	Hepatocellular carcinoma (HP:0001402)	1.68474582
99	Abnormality of the ileum (HP:0001549)	1.65598209
100	IgM deficiency (HP:0002850)	1.64125145

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.40057820
2	NME2	3.02196224
3	FRK	2.69311913
4	PINK1	2.61326731
5	FES	2.57693749
6	CSNK1A1L	2.50344380
7	NUAK1	2.32180181
8	NEK9	2.21646266
9	MST1R	2.17769653
10	TAOK3	2.16207882
11	CSNK1G3	2.08854960
12	ADRBK2	2.07194790
13	NEK2	2.00007800
14	NLK	1.92971698
15	ZAK	1.92481681
16	MAP2K7	1.88540141
17	EIF2AK3	1.85455339
18	CSNK1G1	1.82994986
19	OBSCN	1.72730635
20	GRK1	1.71840409
21	BMPR1B	1.64213761
22	MARK3	1.63715473
23	ERBB3	1.62503121
24	STK38L	1.57666868
25	CSNK1G2	1.50551076
26	TGFBR2	1.37398283
27	MAP4K2	1.37156479
28	LATS1	1.35479875
29	GRK6	1.34042899
30	BLK	1.28876260
31	GRK7	1.24235084
32	NEK1	1.20243351
33	FER	1.19572458
34	BTK	1.16885942
35	STK4	1.14987401
36	PRKCQ	1.11764930
37	TEC	1.11173177
38	SGK2	1.10318991
39	WNK3	1.07569200
40	CDK3	1.02594103
41	ACVR1B	1.01931217
42	MAP3K4	0.98460694
43	AKT3	0.96269879
44	HCK	0.92863208
45	BRSK2	0.92763361
46	SYK	0.91274952
47	IKBKB	0.86933021
48	PAK3	0.86152600
49	SGK223	0.86142049
50	SGK494	0.86142049
51	IKBKE	0.86122924
52	TLK1	0.85847403
53	TIE1	0.84532475
54	MET	0.82049739
55	EIF2AK2	0.81335946
56	TRPM7	0.80995901
57	MOS	0.80523761
58	MAP3K6	0.80057686
59	MAP3K2	0.79778263
60	JAK1	0.76850894
61	MAP3K14	0.76514335
62	PIK3CG	0.73957738
63	STK3	0.72415933
64	GRK5	0.71571283
65	VRK1	0.67181213
66	MAPK7	0.64460333
67	MST4	0.62092125
68	ZAP70	0.60016264
69	BRD4	0.60016183
70	TNIK	0.59214266
71	SGK3	0.58508932
72	TYK2	0.57280560
73	DAPK2	0.57056079
74	MYLK	0.56569212
75	ADRBK1	0.55534621
76	MELK	0.53654802
77	BCR	0.53071650
78	WEE1	0.52430719
79	RPS6KA4	0.51749033
80	PIM1	0.51541828
81	CSNK1A1	0.49975176
82	ITK	0.48793715
83	PRKAA2	0.47709609
84	LYN	0.45846221
85	DYRK3	0.45810161
86	RPS6KB1	0.43969237
87	STK10	0.43346693
88	PLK2	0.41909208
89	MAP3K5	0.41609042
90	IGF1R	0.41264949
91	JAK2	0.41091492
92	EIF2AK1	0.40085549
93	PIK3CA	0.39826894
94	WNK1	0.39681321
95	CHUK	0.38433990
96	EGFR	0.37919565
97	TGFBR1	0.36475830
98	MAPK13	0.35305237
99	IRAK2	0.35277816
100	STK38	0.35071804

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.52306731
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.15037990
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.95417442
4	Phototransduction_Homo sapiens_hsa04744	2.75965525
5	Basal transcription factors_Homo sapiens_hsa03022	2.51489323
6	Olfactory transduction_Homo sapiens_hsa04740	2.35594858
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.34211617
8	Circadian rhythm_Homo sapiens_hsa04710	2.28733462
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.22965206
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.20306348
11	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.16444158
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.02876186
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.97939984
14	Regulation of autophagy_Homo sapiens_hsa04140	1.86954011
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.85747815
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.81154834
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79227505
18	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.75318335
19	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.74422112
20	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.64456525
21	Herpes simplex infection_Homo sapiens_hsa05168	1.61316719
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.60784047
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.46914640
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.44214281
25	Proteasome_Homo sapiens_hsa03050	1.37988234
26	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.36833682
27	Caffeine metabolism_Homo sapiens_hsa00232	1.34807519
28	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.34260706
29	RNA degradation_Homo sapiens_hsa03018	1.33721208
30	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.32919739
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.31830096
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.27575353
33	Measles_Homo sapiens_hsa05162	1.23036992
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.20185831
35	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.18991641
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14349625
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.12524048
38	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.09944654
39	Taste transduction_Homo sapiens_hsa04742	1.03487454
40	Homologous recombination_Homo sapiens_hsa03440	1.02421601
41	Alcoholism_Homo sapiens_hsa05034	1.02323241
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00556905
43	Oocyte meiosis_Homo sapiens_hsa04114	0.97526095
44	TNF signaling pathway_Homo sapiens_hsa04668	0.95095030
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.94415093
46	Propanoate metabolism_Homo sapiens_hsa00640	0.86825097
47	Apoptosis_Homo sapiens_hsa04210	0.85898590
48	mTOR signaling pathway_Homo sapiens_hsa04150	0.85499766
49	Hepatitis B_Homo sapiens_hsa05161	0.80324919
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.80217622
51	Melanoma_Homo sapiens_hsa05218	0.79482809
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.78173990
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.76302844
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75398129
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74921463
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74005971
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.73436451
58	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70777628
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70701213
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.70654155
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.68177916
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68114775
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67811142
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.67361022
65	Renin secretion_Homo sapiens_hsa04924	0.64555651
66	Salivary secretion_Homo sapiens_hsa04970	0.62889535
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.61375290
68	Thyroid cancer_Homo sapiens_hsa05216	0.59666512
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58505306
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56899168
71	Allograft rejection_Homo sapiens_hsa05330	0.55174726
72	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54643201
73	Asthma_Homo sapiens_hsa05310	0.54451168
74	Influenza A_Homo sapiens_hsa05164	0.53867149
75	Purine metabolism_Homo sapiens_hsa00230	0.52711933
76	Peroxisome_Homo sapiens_hsa04146	0.50318349
77	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.49475224
78	Legionellosis_Homo sapiens_hsa05134	0.49191995
79	p53 signaling pathway_Homo sapiens_hsa04115	0.48411200
80	Osteoclast differentiation_Homo sapiens_hsa04380	0.45116518
81	RNA polymerase_Homo sapiens_hsa03020	0.44832786
82	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.43389997
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43132199
84	Butanoate metabolism_Homo sapiens_hsa00650	0.41483140
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.40908486
86	Non-small cell lung cancer_Homo sapiens_hsa05223	0.39496522
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39375005
88	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38368009
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34857135
90	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.34794120
91	Gastric acid secretion_Homo sapiens_hsa04971	0.33998620
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.33576913
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31964309
94	Lysine degradation_Homo sapiens_hsa00310	0.28780740
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.28258435
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28221817
97	ABC transporters_Homo sapiens_hsa02010	0.26636848
98	MicroRNAs in cancer_Homo sapiens_hsa05206	0.25170491
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.24996545
100	Retinol metabolism_Homo sapiens_hsa00830	0.24477319

RBBP4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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