ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	5.54505269
2	adenosine metabolic process (GO:0046085)	4.91886885
3	sequestering of actin monomers (GO:0042989)	4.73806022
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.50556250
5	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.32512977
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.32512977
7	ubiquinone metabolic process (GO:0006743)	4.13902566
8	DNA double-strand break processing (GO:0000729)	4.09588916
9	mannosylation (GO:0097502)	4.08077755
10	ubiquinone biosynthetic process (GO:0006744)	4.05237743
11	sleep (GO:0030431)	4.05138530
12	piRNA metabolic process (GO:0034587)	3.99418882
13	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.83858811
14	metallo-sulfur cluster assembly (GO:0031163)	3.83337303
15	iron-sulfur cluster assembly (GO:0016226)	3.83337303
16	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.69766719
17	regulation of mitotic spindle checkpoint (GO:1903504)	3.69766719
18	response to pheromone (GO:0019236)	3.66211097
19	protein polyglutamylation (GO:0018095)	3.58661735
20	postreplication repair (GO:0006301)	3.56902822
21	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.54820445
22	glucosamine-containing compound catabolic process (GO:1901072)	3.37796591
23	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.37349171
24	quinone biosynthetic process (GO:1901663)	3.35675801
25	DNA replication-dependent nucleosome organization (GO:0034723)	3.31222570
26	DNA replication-dependent nucleosome assembly (GO:0006335)	3.31222570
27	behavioral response to nicotine (GO:0035095)	3.30639241
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.29066301
29	L-serine metabolic process (GO:0006563)	3.18922218
30	DNA deamination (GO:0045006)	3.16472377
31	positive regulation of prostaglandin secretion (GO:0032308)	3.13622011
32	inositol phosphate dephosphorylation (GO:0046855)	3.11291225
33	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.11291225
34	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.06662934
35	cullin deneddylation (GO:0010388)	3.06346483
36	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04370036
37	DNA damage response, detection of DNA damage (GO:0042769)	3.01083350
38	amino acid salvage (GO:0043102)	2.99666746
39	L-methionine salvage (GO:0071267)	2.99666746
40	L-methionine biosynthetic process (GO:0071265)	2.99666746
41	rRNA methylation (GO:0031167)	2.99421329
42	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.98462751
43	ATP synthesis coupled proton transport (GO:0015986)	2.98462751
44	regulation of fever generation (GO:0031620)	2.94614557
45	inositol phosphate catabolic process (GO:0071545)	2.94446673
46	protein deneddylation (GO:0000338)	2.93771109
47	platelet dense granule organization (GO:0060155)	2.92131949
48	morphogenesis of an endothelium (GO:0003159)	2.91316129
49	endothelial tube morphogenesis (GO:0061154)	2.91316129
50	replication fork processing (GO:0031297)	2.90372965
51	mitochondrial RNA metabolic process (GO:0000959)	2.90094358
52	kynurenine metabolic process (GO:0070189)	2.87734718
53	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.87642462
54	regulation of development, heterochronic (GO:0040034)	2.87501475
55	protein complex biogenesis (GO:0070271)	2.85776191
56	cellular response to interleukin-15 (GO:0071350)	2.85626415
57	positive regulation of heat generation (GO:0031652)	2.85567687
58	negative regulation of glucose transport (GO:0010829)	2.85249148
59	cholesterol biosynthetic process (GO:0006695)	2.84058174
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.82544247
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82264762
62	L-fucose catabolic process (GO:0042355)	2.82209045
63	fucose catabolic process (GO:0019317)	2.82209045
64	L-fucose metabolic process (GO:0042354)	2.82209045
65	male sex determination (GO:0030238)	2.78924450
66	spliceosomal snRNP assembly (GO:0000387)	2.77413754
67	pyrimidine nucleobase catabolic process (GO:0006208)	2.77073717
68	tryptophan metabolic process (GO:0006568)	2.75431702
69	protein K11-linked ubiquitination (GO:0070979)	2.72705629
70	neural tube formation (GO:0001841)	2.72527723
71	regulation of heat generation (GO:0031650)	2.70803527
72	isoprenoid biosynthetic process (GO:0008299)	2.70389231
73	mismatch repair (GO:0006298)	2.70225616
74	rRNA modification (GO:0000154)	2.69846059
75	regulation of hexokinase activity (GO:1903299)	2.68895815
76	regulation of glucokinase activity (GO:0033131)	2.68895815
77	protein K11-linked deubiquitination (GO:0035871)	2.67955917
78	recombinational repair (GO:0000725)	2.66269756
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64897497
80	ribonucleoprotein complex disassembly (GO:0032988)	2.64628151
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.63430011
82	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.60697134
83	NADH dehydrogenase complex assembly (GO:0010257)	2.60697134
84	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.60697134
85	protein neddylation (GO:0045116)	2.60610355
86	GPI anchor metabolic process (GO:0006505)	2.59194231
87	intraciliary transport (GO:0042073)	2.58719559
88	translesion synthesis (GO:0019985)	2.57597942
89	tryptophan catabolic process (GO:0006569)	2.55499791
90	indole-containing compound catabolic process (GO:0042436)	2.55499791
91	indolalkylamine catabolic process (GO:0046218)	2.55499791
92	double-strand break repair via homologous recombination (GO:0000724)	2.55258287
93	gamma-aminobutyric acid transport (GO:0015812)	2.55005732
94	regulation of timing of cell differentiation (GO:0048505)	2.54760586
95	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.54528763
96	isotype switching (GO:0045190)	2.54528763
97	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.54528763
98	mitochondrial calcium ion transport (GO:0006851)	2.53672106
99	histone H2A acetylation (GO:0043968)	2.52994552
100	oxidative phosphorylation (GO:0006119)	2.51029509

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.09384070
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50589793
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14136915
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09610470
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02196657
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.56760597
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.48195701
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.45297829
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42441903
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41505051
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.40293062
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39782027
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.33772875
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.22161691
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15314237
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13166145
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.99802053
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.99575534
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.99354967
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98172004
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.98020383
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94805205
23	EWS_26573619_Chip-Seq_HEK293_Human	1.94084700
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91089883
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89749634
26	VDR_22108803_ChIP-Seq_LS180_Human	1.89448627
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87378733
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.82811357
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79686079
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78154979
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.77289411
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74605878
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.73638853
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.73070622
35	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.64753397
36	FUS_26573619_Chip-Seq_HEK293_Human	1.61140440
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.61045691
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.59122427
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55908714
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.55908714
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54126676
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51664062
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.48909880
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48416203
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.46128250
46	P300_19829295_ChIP-Seq_ESCs_Human	1.45430185
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.45213707
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.40274858
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40012951
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38025815
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37400983
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37046603
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36148916
54	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.35280138
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30523827
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28681274
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28681274
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.28669431
59	NCOR_22424771_ChIP-Seq_293T_Human	1.26926115
60	AR_20517297_ChIP-Seq_VCAP_Human	1.24164771
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21300583
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19397163
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19213847
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16587225
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12010495
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12010495
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11342903
68	E2F7_22180533_ChIP-Seq_HELA_Human	1.08830001
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06131861
70	CIITA_25753668_ChIP-Seq_RAJI_Human	1.03350937
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03290660
72	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02899310
73	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.01791000
74	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.01110092
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01046663
76	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00880245
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.00699031
78	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99571024
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98185716
80	GATA3_26560356_Chip-Seq_TH2_Human	0.98008535
81	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.97998586
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97362719
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95408820
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95200113
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95043859
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94478618
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94372504
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92571080
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92343922
90	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.91899119
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91553584
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91065594
93	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.90563837
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90221427
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.88866423
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.88757816
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.88508513
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.87016954
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.86922224
100	TTF2_22483619_ChIP-Seq_HELA_Human	0.86647426

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.26252410
2	MP0003195_calcinosis	3.62716571
3	MP0004043_abnormal_pH_regulation	3.07807317
4	MP0003011_delayed_dark_adaptation	2.89100173
5	MP0008995_early_reproductive_senescence	2.87447794
6	MP0008877_abnormal_DNA_methylation	2.53380032
7	MP0002102_abnormal_ear_morphology	2.50905913
8	MP0006072_abnormal_retinal_apoptosis	2.40873329
9	MP0001986_abnormal_taste_sensitivity	2.36237460
10	MP0005377_hearing/vestibular/ear_phenot	2.09956228
11	MP0003878_abnormal_ear_physiology	2.09956228
12	MP0002822_catalepsy	2.05520962
13	MP0004885_abnormal_endolymph	2.05005284
14	MP0005084_abnormal_gallbladder_morpholo	2.03256427
15	MP0003656_abnormal_erythrocyte_physiolo	1.99078617
16	MP0000372_irregular_coat_pigmentation	1.99040929
17	MP0008789_abnormal_olfactory_epithelium	1.98570535
18	MP0005253_abnormal_eye_physiology	1.95410688
19	MP0003786_premature_aging	1.94993280
20	MP0005551_abnormal_eye_electrophysiolog	1.86551303
21	MP0003724_increased_susceptibility_to	1.82808928
22	MP0006054_spinal_hemorrhage	1.77085153
23	MP0006276_abnormal_autonomic_nervous	1.75691733
24	MP0002139_abnormal_hepatobiliary_system	1.74052509
25	MP0000465_gastrointestinal_hemorrhage	1.68393652
26	MP0005075_abnormal_melanosome_morpholog	1.68057449
27	MP0005645_abnormal_hypothalamus_physiol	1.67890360
28	MP0010094_abnormal_chromosome_stability	1.63370220
29	MP0003122_maternal_imprinting	1.63079691
30	MP0005394_taste/olfaction_phenotype	1.62520707
31	MP0005499_abnormal_olfactory_system	1.62520707
32	MP0001529_abnormal_vocalization	1.57919554
33	MP0004133_heterotaxia	1.54414285
34	MP0001501_abnormal_sleep_pattern	1.51814979
35	MP0001485_abnormal_pinna_reflex	1.51325188
36	MP0003136_yellow_coat_color	1.49639709
37	MP0003121_genomic_imprinting	1.45656148
38	MP0006292_abnormal_olfactory_placode	1.45032584
39	MP0009745_abnormal_behavioral_response	1.44593087
40	MP0002638_abnormal_pupillary_reflex	1.41736804
41	MP0001188_hyperpigmentation	1.35809723
42	MP0003693_abnormal_embryo_hatching	1.33816056
43	MP0009046_muscle_twitch	1.32794064
44	MP0009697_abnormal_copulation	1.32620254
45	MP0002095_abnormal_skin_pigmentation	1.31621376
46	MP0001968_abnormal_touch/_nociception	1.31214848
47	MP0003718_maternal_effect	1.27313158
48	MP0002736_abnormal_nociception_after	1.25811675
49	MP0002277_abnormal_respiratory_mucosa	1.22906192
50	MP0001486_abnormal_startle_reflex	1.19086291
51	MP0003880_abnormal_central_pattern	1.17065796
52	MP0001324_abnormal_eye_pigmentation	1.13721057
53	MP0002572_abnormal_emotion/affect_behav	1.13700258
54	MP0001984_abnormal_olfaction	1.13003349
55	MP0005389_reproductive_system_phenotype	1.12582391
56	MP0002272_abnormal_nervous_system	1.12237516
57	MP0002138_abnormal_hepatobiliary_system	1.10971567
58	MP0005671_abnormal_response_to	1.09679809
59	MP0005646_abnormal_pituitary_gland	1.08507230
60	MP0002735_abnormal_chemical_nociception	1.05349717
61	MP0001970_abnormal_pain_threshold	1.04890177
62	MP0002733_abnormal_thermal_nociception	1.00927484
63	MP0000049_abnormal_middle_ear	1.00193458
64	MP0000631_abnormal_neuroendocrine_gland	0.98872788
65	MP0001919_abnormal_reproductive_system	0.97764582
66	MP0008872_abnormal_physiological_respon	0.95762569
67	MP0002557_abnormal_social/conspecific_i	0.95714265
68	MP0005167_abnormal_blood-brain_barrier	0.93627298
69	MP0008058_abnormal_DNA_repair	0.92307934
70	MP0002653_abnormal_ependyma_morphology	0.92297832
71	MP0009764_decreased_sensitivity_to	0.92052692
72	MP0001542_abnormal_bone_strength	0.90697372
73	MP0002234_abnormal_pharynx_morphology	0.90118100
74	MP0002160_abnormal_reproductive_system	0.89665907
75	MP0002928_abnormal_bile_duct	0.87850572
76	MP0001727_abnormal_embryo_implantation	0.87413975
77	MP0003221_abnormal_cardiomyocyte_apopto	0.84316079
78	MP0006036_abnormal_mitochondrial_physio	0.83089390
79	MP0008961_abnormal_basal_metabolism	0.81658841
80	MP0003137_abnormal_impulse_conducting	0.80991004
81	MP0005195_abnormal_posterior_eye	0.79446859
82	MP0000647_abnormal_sebaceous_gland	0.79423831
83	MP0002067_abnormal_sensory_capabilities	0.79046108
84	MP0005391_vision/eye_phenotype	0.78978089
85	MP0001764_abnormal_homeostasis	0.76391414
86	MP0003638_abnormal_response/metabolism_	0.75226366
87	MP0004742_abnormal_vestibular_system	0.74988194
88	MP0006035_abnormal_mitochondrial_morpho	0.74142211
89	MP0001293_anophthalmia	0.73451539
90	MP0002063_abnormal_learning/memory/cond	0.72760152
91	MP0003890_abnormal_embryonic-extraembry	0.72482890
92	MP0002909_abnormal_adrenal_gland	0.71863982
93	MP0005360_urolithiasis	0.71124309
94	MP0002064_seizures	0.70296958
95	MP0001963_abnormal_hearing_physiology	0.69786007
96	MP0004130_abnormal_muscle_cell	0.69549337
97	MP0002090_abnormal_vision	0.69433748
98	MP0003186_abnormal_redox_activity	0.68206564
99	MP0008932_abnormal_embryonic_tissue	0.67860659
100	MP0005636_abnormal_mineral_homeostasis	0.67180726

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.06744970
2	Pancreatic fibrosis (HP:0100732)	3.50632455
3	Pancreatic cysts (HP:0001737)	3.29853727
4	Congenital stationary night blindness (HP:0007642)	3.11678522
5	True hermaphroditism (HP:0010459)	3.01846644
6	Molar tooth sign on MRI (HP:0002419)	3.00061066
7	Abnormality of midbrain morphology (HP:0002418)	3.00061066
8	Type II lissencephaly (HP:0007260)	2.98046618
9	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.89435844
10	Hypoplasia of the fovea (HP:0007750)	2.89435844
11	Medial flaring of the eyebrow (HP:0010747)	2.85357334
12	Short tibia (HP:0005736)	2.77849798
13	Renal cortical cysts (HP:0000803)	2.65202821
14	Adrenal hypoplasia (HP:0000835)	2.60946833
15	Meckel diverticulum (HP:0002245)	2.59636265
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.58755394
17	Abolished electroretinogram (ERG) (HP:0000550)	2.58639136
18	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.56644340
19	Lissencephaly (HP:0001339)	2.55359743
20	Methylmalonic acidemia (HP:0002912)	2.54208317
21	Median cleft lip (HP:0000161)	2.51236217
22	Congenital primary aphakia (HP:0007707)	2.49371753
23	Retinal dysplasia (HP:0007973)	2.45986827
24	IgG deficiency (HP:0004315)	2.44912562
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.44856172
26	Abnormality of the ileum (HP:0001549)	2.44555534
27	Constricted visual fields (HP:0001133)	2.42456755
28	Abnormality of the labia minora (HP:0012880)	2.41420914
29	Lipid accumulation in hepatocytes (HP:0006561)	2.40321267
30	Gait imbalance (HP:0002141)	2.40197714
31	Thyroid-stimulating hormone excess (HP:0002925)	2.39566360
32	Nephrogenic diabetes insipidus (HP:0009806)	2.38643534
33	Hypoglycemic coma (HP:0001325)	2.37977453
34	Nephronophthisis (HP:0000090)	2.37187426
35	Type I transferrin isoform profile (HP:0003642)	2.37056201
36	Increased hepatocellular lipid droplets (HP:0006565)	2.35314438
37	Abnormality of the fovea (HP:0000493)	2.34691197
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.30783732
39	Genital tract atresia (HP:0001827)	2.30085522
40	Postaxial foot polydactyly (HP:0001830)	2.28308335
41	Attenuation of retinal blood vessels (HP:0007843)	2.27788485
42	Bile duct proliferation (HP:0001408)	2.27749657
43	Abnormal biliary tract physiology (HP:0012439)	2.27749657
44	Occipital encephalocele (HP:0002085)	2.25773871
45	Progressive inability to walk (HP:0002505)	2.24960986
46	Cerebellar dysplasia (HP:0007033)	2.21265174
47	Abnormality of chromosome stability (HP:0003220)	2.19678633
48	Increased intramyocellular lipid droplets (HP:0012240)	2.17694314
49	Hypothermia (HP:0002045)	2.15860439
50	Clubbing of toes (HP:0100760)	2.15637882
51	Brittle hair (HP:0002299)	2.13482113
52	Methylmalonic aciduria (HP:0012120)	2.12768618
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.12180108
54	Supernumerary spleens (HP:0009799)	2.10987092
55	Opisthotonus (HP:0002179)	2.07414287
56	Abnormality of the renal cortex (HP:0011035)	2.07022050
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06153586
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.06153586
59	Abnormal protein glycosylation (HP:0012346)	2.06153586
60	Abnormal glycosylation (HP:0012345)	2.06153586
61	Chronic hepatic failure (HP:0100626)	2.05171377
62	Hyperglycinemia (HP:0002154)	2.05101180
63	Preaxial hand polydactyly (HP:0001177)	2.04740234
64	Vaginal atresia (HP:0000148)	2.03949118
65	Congenital hepatic fibrosis (HP:0002612)	2.01183783
66	Hypoplasia of the uterus (HP:0000013)	2.00828418
67	Hyperinsulinemic hypoglycemia (HP:0000825)	2.00049748
68	Oligohydramnios (HP:0001562)	1.99428002
69	Abnormality of lateral ventricle (HP:0030047)	1.97516652
70	Abnormality of the preputium (HP:0100587)	1.96119706
71	Postaxial hand polydactyly (HP:0001162)	1.95998483
72	Hypoglycemic seizures (HP:0002173)	1.95263722
73	Male pseudohermaphroditism (HP:0000037)	1.92451633
74	Limb dystonia (HP:0002451)	1.90300203
75	Severe combined immunodeficiency (HP:0004430)	1.89639902
76	Agitation (HP:0000713)	1.89564470
77	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.88941109
78	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.88941109
79	Elevated erythrocyte sedimentation rate (HP:0003565)	1.88899342
80	Gonadal dysgenesis (HP:0000133)	1.88598604
81	Neonatal respiratory distress (HP:0002643)	1.87691084
82	Asplenia (HP:0001746)	1.85143207
83	Pachygyria (HP:0001302)	1.83865295
84	Cystic liver disease (HP:0006706)	1.83577039
85	Acute encephalopathy (HP:0006846)	1.83003531
86	Stomatitis (HP:0010280)	1.82932221
87	Furrowed tongue (HP:0000221)	1.81044217
88	Increased serum lactate (HP:0002151)	1.80758750
89	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80434193
90	Sclerocornea (HP:0000647)	1.80190504
91	Absent speech (HP:0001344)	1.79429004
92	Abnormality of methionine metabolism (HP:0010901)	1.79236134
93	Astigmatism (HP:0000483)	1.78547235
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.78403877
95	Increased muscle lipid content (HP:0009058)	1.78210857
96	Increased CSF lactate (HP:0002490)	1.77671971
97	Abnormality of the renal medulla (HP:0100957)	1.77593942
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76025115
99	Specific learning disability (HP:0001328)	1.75968778
100	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.75420750

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.13365554
2	TXK	3.06233138
3	ZAK	2.99714077
4	MUSK	2.88621756
5	FES	2.86387616
6	TRIM28	2.68043930
7	NUAK1	2.59196693
8	GRK6	2.52021701
9	BRSK2	2.25974185
10	VRK2	2.18231097
11	MKNK1	2.12281632
12	INSRR	2.07799913
13	ADRBK2	2.06666564
14	MST4	1.97970907
15	NEK1	1.95193792
16	CDC7	1.88732886
17	TLK1	1.87165884
18	VRK1	1.85743714
19	TAF1	1.78056974
20	NME1	1.73842941
21	FER	1.72663692
22	CSNK1G3	1.57290703
23	CSNK1G2	1.50205467
24	BCR	1.49481260
25	WNK3	1.46625168
26	CSNK1A1L	1.45282629
27	BCKDK	1.44299025
28	CAMKK2	1.41395891
29	TAOK3	1.38159892
30	CDK3	1.31153662
31	CSNK1G1	1.29676965
32	TGFBR1	1.26604564
33	BMPR1B	1.20251787
34	PLK4	1.20075307
35	MAPKAPK5	1.15037293
36	PLK3	1.11286247
37	GRK1	1.07751219
38	STK39	1.04385800
39	KIT	1.03805294
40	MAP4K1	1.02495360
41	LIMK1	1.02088817
42	DYRK2	0.95420030
43	MAP2K7	0.92654784
44	WNK4	0.90930121
45	TESK2	0.83788969
46	MAP3K4	0.82914696
47	MAP2K2	0.82183656
48	MAPK13	0.80423733
49	CCNB1	0.78206148
50	PLK2	0.77884221
51	PAK3	0.77426577
52	DAPK1	0.72850850
53	BRSK1	0.70709694
54	WEE1	0.70189355
55	PASK	0.68064817
56	OXSR1	0.67335738
57	ATR	0.65763636
58	IKBKB	0.65634835
59	SRPK1	0.64971508
60	TIE1	0.64269155
61	EPHA4	0.63335458
62	KDR	0.61313957
63	MARK1	0.60777100
64	PINK1	0.59822386
65	MYLK	0.59653620
66	TNK2	0.58797719
67	PAK6	0.58742235
68	EIF2AK3	0.58483272
69	RPS6KA5	0.56825185
70	PRKCE	0.55914838
71	PIM2	0.55499679
72	EPHA3	0.54536539
73	DAPK2	0.54010717
74	EIF2AK2	0.53364647
75	PLK1	0.52936011
76	ERBB3	0.52634334
77	TBK1	0.50333182
78	PKN1	0.50219114
79	CSNK1A1	0.47602491
80	FRK	0.45432870
81	BUB1	0.45072246
82	LYN	0.43006904
83	PRKACB	0.41863053
84	IGF1R	0.41758123
85	PRKCQ	0.39843652
86	TESK1	0.39332894
87	MKNK2	0.39330457
88	CSNK2A1	0.38524511
89	ADRBK1	0.38067615
90	GRK5	0.37932802
91	EGFR	0.37270753
92	PIM1	0.36111186
93	CAMK1	0.36053705
94	EPHB2	0.35356613
95	PRKCG	0.35308863
96	UHMK1	0.32698927
97	TSSK6	0.32686357
98	CSNK1D	0.30804615
99	MAP3K14	0.30696450
100	AURKB	0.29865611

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.74017188
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.64598279
3	Proteasome_Homo sapiens_hsa03050	2.51339174
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.43058089
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38438534
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.38028469
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35895259
8	Fatty acid elongation_Homo sapiens_hsa00062	2.32771207
9	Protein export_Homo sapiens_hsa03060	2.31743865
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.17074256
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.12271599
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.11380870
13	Parkinsons disease_Homo sapiens_hsa05012	2.09719526
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02803470
15	Basal transcription factors_Homo sapiens_hsa03022	2.00239830
16	Homologous recombination_Homo sapiens_hsa03440	1.98271666
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93862681
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92977699
19	Mismatch repair_Homo sapiens_hsa03430	1.80161776
20	DNA replication_Homo sapiens_hsa03030	1.72473576
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.66137939
22	Spliceosome_Homo sapiens_hsa03040	1.63547735
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.58186086
24	Phototransduction_Homo sapiens_hsa04744	1.52100852
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.51786689
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.45771196
27	Nicotine addiction_Homo sapiens_hsa05033	1.45287019
28	Propanoate metabolism_Homo sapiens_hsa00640	1.44483665
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.43308907
30	RNA polymerase_Homo sapiens_hsa03020	1.42724851
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.39438182
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.31527923
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29274462
34	Base excision repair_Homo sapiens_hsa03410	1.27846192
35	One carbon pool by folate_Homo sapiens_hsa00670	1.27634626
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.19105005
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16860447
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16384732
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.12837201
40	Butanoate metabolism_Homo sapiens_hsa00650	1.12788247
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12691899
42	RNA degradation_Homo sapiens_hsa03018	1.07563037
43	Alzheimers disease_Homo sapiens_hsa05010	1.03672882
44	Huntingtons disease_Homo sapiens_hsa05016	1.03633294
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.01574153
46	Purine metabolism_Homo sapiens_hsa00230	1.01507359
47	Sulfur metabolism_Homo sapiens_hsa00920	1.00450256
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00087037
49	Regulation of autophagy_Homo sapiens_hsa04140	0.99900427
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99161744
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98870060
52	RNA transport_Homo sapiens_hsa03013	0.98187618
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.94723647
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.93999837
55	Folate biosynthesis_Homo sapiens_hsa00790	0.90048464
56	Asthma_Homo sapiens_hsa05310	0.88684274
57	GABAergic synapse_Homo sapiens_hsa04727	0.88406610
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88227942
59	Peroxisome_Homo sapiens_hsa04146	0.87847670
60	Morphine addiction_Homo sapiens_hsa05032	0.87077207
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84577737
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83531600
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.82802032
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.82180412
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81570549
66	Metabolic pathways_Homo sapiens_hsa01100	0.77106040
67	Glutathione metabolism_Homo sapiens_hsa00480	0.72143919
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64905315
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63677320
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.62442942
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61867169
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60558306
73	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57694949
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.55195959
75	Carbon metabolism_Homo sapiens_hsa01200	0.53828557
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.53548326
77	Caffeine metabolism_Homo sapiens_hsa00232	0.53052668
78	Taste transduction_Homo sapiens_hsa04742	0.52951592
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.51010614
80	Serotonergic synapse_Homo sapiens_hsa04726	0.50285624
81	Oocyte meiosis_Homo sapiens_hsa04114	0.49964825
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48133327
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47712622
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46982810
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46688496
86	Circadian rhythm_Homo sapiens_hsa04710	0.46057850
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45553308
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45027452
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44509185
90	Retinol metabolism_Homo sapiens_hsa00830	0.44283350
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.43020846
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42434915
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40030343
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39499097
95	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38365594
96	Cell cycle_Homo sapiens_hsa04110	0.36774287
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34759522
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33948123
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33342099
100	Ribosome_Homo sapiens_hsa03010	0.31025527

RBBP4P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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