RBBP4P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)5.63182168
2DNA deamination (GO:0045006)5.40567525
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.30770846
4cytidine metabolic process (GO:0046087)4.88090361
5cytidine catabolic process (GO:0006216)4.88090361
6cytidine deamination (GO:0009972)4.88090361
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.78937634
8cell wall macromolecule metabolic process (GO:0044036)4.71344787
9cellular response to interleukin-15 (GO:0071350)4.38631936
10regulation of germinal center formation (GO:0002634)4.30762925
11actin nucleation (GO:0045010)4.28740020
12interferon-gamma production (GO:0032609)4.26814247
13adaptation of signaling pathway (GO:0023058)4.17853761
14pyrimidine ribonucleoside catabolic process (GO:0046133)4.00831011
15DNA double-strand break processing (GO:0000729)3.94884738
16positive regulation of prostaglandin secretion (GO:0032308)3.77291485
17regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.57693280
18sequestering of actin monomers (GO:0042989)3.53659412
19regulation of T cell chemotaxis (GO:0010819)3.48033092
20positive regulation of T cell chemotaxis (GO:0010820)3.48033092
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41646061
22urate metabolic process (GO:0046415)3.38537736
23regulation of cellular amino acid metabolic process (GO:0006521)3.38010173
24protein deneddylation (GO:0000338)3.36053320
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35345635
26regulation of mitotic spindle checkpoint (GO:1903504)3.35345635
27DNA replication-dependent nucleosome assembly (GO:0006335)3.33776694
28DNA replication-dependent nucleosome organization (GO:0034723)3.33776694
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31618948
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31618948
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31618948
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30545832
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30545832
34positive regulation of defense response to virus by host (GO:0002230)3.30387887
35DNA catabolic process, exonucleolytic (GO:0000738)3.22333534
36DNA ligation (GO:0006266)3.20644939
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20556079
38CENP-A containing nucleosome assembly (GO:0034080)3.19388834
39rRNA catabolic process (GO:0016075)3.17598335
40response to interferon-beta (GO:0035456)3.16371374
41protein-cofactor linkage (GO:0018065)3.14714925
42positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.13963251
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.13931262
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13931262
45ubiquinone biosynthetic process (GO:0006744)3.13780381
46regulation of T cell mediated cytotoxicity (GO:0001914)3.13761385
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.13670266
48cullin deneddylation (GO:0010388)3.12448636
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11226711
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11226711
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10865038
52response to interleukin-15 (GO:0070672)3.06786396
53positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.06782247
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05437873
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05437873
56isotype switching (GO:0045190)3.05437873
57adenosine metabolic process (GO:0046085)3.01165359
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98645480
59ncRNA catabolic process (GO:0034661)2.97979586
60sleep (GO:0030431)2.97425282
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97114758
62positive regulation of ligase activity (GO:0051351)2.96495983
63positive regulation of alpha-beta T cell proliferation (GO:0046641)2.95831625
64chromatin remodeling at centromere (GO:0031055)2.94318855
65ubiquinone metabolic process (GO:0006743)2.94003609
66positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93265984
67regulation of immunoglobulin secretion (GO:0051023)2.92239147
68regulation of B cell receptor signaling pathway (GO:0050855)2.87995705
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87517661
70positive regulation of protein homodimerization activity (GO:0090073)2.87402670
71positive regulation of T cell cytokine production (GO:0002726)2.87202403
72regulation of prostaglandin secretion (GO:0032306)2.86783481
73positive regulation of cell cycle G1/S phase transition (GO:1902808)2.84632754
74protein polyglutamylation (GO:0018095)2.83875840
75regulation of interleukin-8 secretion (GO:2000482)2.81561956
76negative regulation of ligase activity (GO:0051352)2.81295508
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81295508
78protein neddylation (GO:0045116)2.80628716
79cellular response to interferon-beta (GO:0035458)2.78397553
80protein localization to kinetochore (GO:0034501)2.77646454
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75885385
82negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.74948495
83regulation of memory T cell differentiation (GO:0043380)2.73920855
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72460221
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68681911
86iron-sulfur cluster assembly (GO:0016226)2.67653510
87metallo-sulfur cluster assembly (GO:0031163)2.67653510
88positive regulation of interleukin-8 secretion (GO:2000484)2.67308209
89DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.66826226
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65132684
91mitotic cell cycle arrest (GO:0071850)2.65110681
92negative regulation of T cell differentiation in thymus (GO:0033085)2.63819004
93positive regulation of heat generation (GO:0031652)2.61758490
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61707680
95positive regulation of cell cycle arrest (GO:0071158)2.59310705
96regulation of leukocyte mediated cytotoxicity (GO:0001910)2.58366859
97cellular ketone body metabolic process (GO:0046950)2.57610365
98non-recombinational repair (GO:0000726)2.57564839
99double-strand break repair via nonhomologous end joining (GO:0006303)2.57564839
100deoxyribonucleotide catabolic process (GO:0009264)2.55817888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.56591653
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62699074
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.32711021
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.12660422
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97630634
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.96641883
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93004530
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.92544428
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89472733
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.82655816
11E2F7_22180533_ChIP-Seq_HELA_Human2.78402189
12VDR_23849224_ChIP-Seq_CD4+_Human2.67964113
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64953078
14ELK1_19687146_ChIP-ChIP_HELA_Human2.51289985
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50965092
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40390313
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.38046875
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20506244
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20324042
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.16268737
21ZNF274_21170338_ChIP-Seq_K562_Hela2.12673035
22IGF1R_20145208_ChIP-Seq_DFB_Human2.11769748
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09391053
24FOXP3_21729870_ChIP-Seq_TREG_Human2.08256675
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.08104547
26VDR_22108803_ChIP-Seq_LS180_Human1.97315975
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96971575
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93956067
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90255807
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88332992
31MYB_26560356_Chip-Seq_TH2_Human1.80704789
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78090693
33EWS_26573619_Chip-Seq_HEK293_Human1.73883561
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70331643
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.64646469
36GATA3_26560356_Chip-Seq_TH2_Human1.63631971
37RUNX_20019798_ChIP-Seq_JUKART_Human1.58474923
38MYC_18940864_ChIP-ChIP_HL60_Human1.46708433
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46558324
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45953927
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43761925
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43748199
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43596265
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41880584
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.41880584
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41071715
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39151118
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38747841
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37122659
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37067480
51AR_20517297_ChIP-Seq_VCAP_Human1.37020385
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35824927
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35672012
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33174284
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33119412
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32020705
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31453492
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29983503
59NANOG_19829295_ChIP-Seq_ESCs_Human1.29684539
60SOX2_19829295_ChIP-Seq_ESCs_Human1.29684539
61GATA3_27048872_Chip-Seq_THYMUS_Human1.28267409
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26997883
63FUS_26573619_Chip-Seq_HEK293_Human1.23645147
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22535608
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20914338
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19295198
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.17436236
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15051591
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.14979909
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14961270
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14905445
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14412624
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14005268
74TP53_22573176_ChIP-Seq_HFKS_Human1.12581524
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12570005
76TAF15_26573619_Chip-Seq_HEK293_Human1.12054130
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11789472
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.10741264
79GATA3_26560356_Chip-Seq_TH1_Human1.10561052
80ER_23166858_ChIP-Seq_MCF-7_Human1.10151638
81SPI1_23547873_ChIP-Seq_NB4_Human1.10038675
82NANOG_20526341_ChIP-Seq_ESCs_Human1.04965680
83P300_19829295_ChIP-Seq_ESCs_Human1.04598741
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04070025
85MYB_26560356_Chip-Seq_TH1_Human1.03892588
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03403206
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03136055
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00761480
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00245245
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97108560
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.96112853
92MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95979394
93IRF1_19129219_ChIP-ChIP_H3396_Human0.95339666
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.95267424
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94557746
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93947961
97CIITA_25753668_ChIP-Seq_RAJI_Human0.92380990
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90602570
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.89268144
100CBP_20019798_ChIP-Seq_JUKART_Human0.88890685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.96276405
2MP0004147_increased_porphyrin_level3.86636045
3MP0003763_abnormal_thymus_physiology3.54223402
4MP0001835_abnormal_antigen_presentation3.02203522
5MP0000685_abnormal_immune_system2.88205548
6MP0002166_altered_tumor_susceptibility2.76944597
7MP0009785_altered_susceptibility_to2.67122167
8MP0003195_calcinosis2.46872678
9MP0002148_abnormal_hypersensitivity_rea2.45764168
10MP0002102_abnormal_ear_morphology2.30544652
11MP0005000_abnormal_immune_tolerance2.29116558
12MP0003724_increased_susceptibility_to2.26595343
13MP0002006_tumorigenesis2.23103735
14MP0002009_preneoplasia2.12103139
15MP0002837_dystrophic_cardiac_calcinosis2.10308234
16MP0001800_abnormal_humoral_immune2.05976237
17MP0000465_gastrointestinal_hemorrhage2.04854110
18MP0003786_premature_aging1.98841135
19MP0001986_abnormal_taste_sensitivity1.98838183
20MP0002723_abnormal_immune_serum1.88392182
21MP0000372_irregular_coat_pigmentation1.84556360
22MP0002452_abnormal_antigen_presenting1.78914521
23MP0002420_abnormal_adaptive_immunity1.78449060
24MP0001819_abnormal_immune_cell1.76739636
25MP0005387_immune_system_phenotype1.73628418
26MP0001790_abnormal_immune_system1.73628418
27MP0006072_abnormal_retinal_apoptosis1.72583345
28MP0002405_respiratory_system_inflammati1.64531901
29MP0010094_abnormal_chromosome_stability1.62765858
30MP0005075_abnormal_melanosome_morpholog1.59505200
31MP0006054_spinal_hemorrhage1.59166585
32MP0001853_heart_inflammation1.52919339
33MP0003436_decreased_susceptibility_to1.47260123
34MP0002398_abnormal_bone_marrow1.45553340
35MP0005645_abnormal_hypothalamus_physiol1.45414828
36MP0002234_abnormal_pharynx_morphology1.45204949
37MP0004145_abnormal_muscle_electrophysio1.43115167
38MP0008058_abnormal_DNA_repair1.39870229
39MP0005084_abnormal_gallbladder_morpholo1.39699644
40MP0000689_abnormal_spleen_morphology1.38446665
41MP0008007_abnormal_cellular_replicative1.37897406
42MP0000716_abnormal_immune_system1.37740520
43MP0002419_abnormal_innate_immunity1.37340408
44MP0010155_abnormal_intestine_physiology1.32149482
45MP0004142_abnormal_muscle_tone1.31433218
46MP0005025_abnormal_response_to1.31131584
47MP0003011_delayed_dark_adaptation1.30273619
48MP0005377_hearing/vestibular/ear_phenot1.29739177
49MP0003878_abnormal_ear_physiology1.29739177
50MP0005646_abnormal_pituitary_gland1.27088027
51MP0002751_abnormal_autonomic_nervous1.23106650
52MP0002722_abnormal_immune_system1.21662779
53MP0003866_abnormal_defecation1.21567631
54MP0009333_abnormal_splenocyte_physiolog1.20585028
55MP0002876_abnormal_thyroid_physiology1.19847030
56MP0003806_abnormal_nucleotide_metabolis1.16962729
57MP0005551_abnormal_eye_electrophysiolog1.16518635
58MP0008872_abnormal_physiological_respon1.14770501
59MP0000703_abnormal_thymus_morphology1.13701049
60MP0002933_joint_inflammation1.13526186
61MP0004134_abnormal_chest_morphology1.13174242
62MP0001845_abnormal_inflammatory_respons1.12827375
63MP0005389_reproductive_system_phenotype1.11243290
64MP0003718_maternal_effect1.09982883
65MP0002429_abnormal_blood_cell1.07698967
66MP0001764_abnormal_homeostasis1.06125687
67MP0005253_abnormal_eye_physiology1.05278265
68MP0001919_abnormal_reproductive_system1.01963497
69MP0002736_abnormal_nociception_after1.01510252
70MP0005167_abnormal_blood-brain_barrier0.99552580
71MP0003252_abnormal_bile_duct0.97188556
72MP0008875_abnormal_xenobiotic_pharmacok0.95882007
73MP0001873_stomach_inflammation0.95503875
74MP0002693_abnormal_pancreas_physiology0.95170848
75MP0006082_CNS_inflammation0.93542394
76MP0008877_abnormal_DNA_methylation0.92714332
77MP0006036_abnormal_mitochondrial_physio0.89612957
78MP0001533_abnormal_skeleton_physiology0.89474853
79MP0001905_abnormal_dopamine_level0.87984380
80MP0001485_abnormal_pinna_reflex0.87003301
81MP0002160_abnormal_reproductive_system0.85318564
82MP0001501_abnormal_sleep_pattern0.84262379
83MP0004084_abnormal_cardiac_muscle0.83600228
84MP0001968_abnormal_touch/_nociception0.83376803
85MP0008789_abnormal_olfactory_epithelium0.82239353
86MP0001984_abnormal_olfaction0.81806523
87MP0004957_abnormal_blastocyst_morpholog0.81411306
88MP0009764_decreased_sensitivity_to0.80761154
89MP0002019_abnormal_tumor_incidence0.77949175
90MP0002095_abnormal_skin_pigmentation0.74985546
91MP0000858_altered_metastatic_potential0.71837942
92MP0002272_abnormal_nervous_system0.71692590
93MP0008775_abnormal_heart_ventricle0.70044512
94MP0009765_abnormal_xenobiotic_induced0.68716717
95MP0004947_skin_inflammation0.67923836
96MP0008469_abnormal_protein_level0.67851624
97MP0005535_abnormal_body_temperature0.67484457
98MP0006035_abnormal_mitochondrial_morpho0.67223768
99MP0005332_abnormal_amino_acid0.67010490
100MP0001727_abnormal_embryo_implantation0.63470886

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.59171617
2Renal cortical cysts (HP:0000803)4.54142319
3Severe combined immunodeficiency (HP:0004430)4.17814702
43-Methylglutaconic aciduria (HP:0003535)3.68225264
5Abnormality of alanine metabolism (HP:0010916)3.66657978
6Hyperalaninemia (HP:0003348)3.66657978
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.66657978
8Combined immunodeficiency (HP:0005387)3.48305499
9Type I transferrin isoform profile (HP:0003642)3.38891191
10Lipid accumulation in hepatocytes (HP:0006561)3.37360416
11Increased hepatocellular lipid droplets (HP:0006565)3.34868381
12T lymphocytopenia (HP:0005403)3.29340679
13Stomatitis (HP:0010280)3.17444378
14Thyroiditis (HP:0100646)3.09993995
15Elevated erythrocyte sedimentation rate (HP:0003565)3.09761326
16Abnormality of T cell number (HP:0011839)3.05209071
17Increased intramyocellular lipid droplets (HP:0012240)3.04457341
18Abnormality of the renal collecting system (HP:0004742)2.91535696
19Pustule (HP:0200039)2.87733873
20Duplicated collecting system (HP:0000081)2.85812854
21Cerebral palsy (HP:0100021)2.81501889
22Abnormality of the prostate (HP:0008775)2.81191771
23Abnormality of T cells (HP:0002843)2.73031010
24Methylmalonic acidemia (HP:0002912)2.70977252
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66590752
26Abnormal protein N-linked glycosylation (HP:0012347)2.66590752
27Abnormal protein glycosylation (HP:0012346)2.66590752
28Abnormal glycosylation (HP:0012345)2.66590752
29Mitochondrial inheritance (HP:0001427)2.65027612
30Increased muscle lipid content (HP:0009058)2.64562887
31Abnormality of the renal cortex (HP:0011035)2.61559884
32Premature loss of primary teeth (HP:0006323)2.52679072
33Renal Fanconi syndrome (HP:0001994)2.49312276
34Abnormality of T cell physiology (HP:0011840)2.44291425
35Congenital stationary night blindness (HP:0007642)2.43714373
36Pancytopenia (HP:0001876)2.41496123
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39190293
38Abnormality of eosinophils (HP:0001879)2.38484991
39Increased CSF lactate (HP:0002490)2.35202360
40Exertional dyspnea (HP:0002875)2.31724868
41Recurrent cutaneous fungal infections (HP:0011370)2.30864219
42Chronic mucocutaneous candidiasis (HP:0002728)2.30864219
43Abolished electroretinogram (ERG) (HP:0000550)2.30653548
44Pancreatic cysts (HP:0001737)2.28251707
45Hepatocellular necrosis (HP:0001404)2.28096456
46Hepatic necrosis (HP:0002605)2.25574934
47Congenital, generalized hypertrichosis (HP:0004540)2.24536712
48IgM deficiency (HP:0002850)2.22665196
49Abnormality of B cell number (HP:0010975)2.17705710
50Volvulus (HP:0002580)2.17345841
51Agammaglobulinemia (HP:0004432)2.12504794
52Abnormality of midbrain morphology (HP:0002418)2.10978017
53Molar tooth sign on MRI (HP:0002419)2.10978017
54Abnormal rod and cone electroretinograms (HP:0008323)2.09909780
55B lymphocytopenia (HP:0010976)2.09729000
56Abnormality of the preputium (HP:0100587)2.07302927
57Abnormality of DNA repair (HP:0003254)2.02178292
58Recurrent bronchitis (HP:0002837)2.01682821
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99313257
60Chronic diarrhea (HP:0002028)1.98610237
61Lactic acidosis (HP:0003128)1.98400545
62Abnormality of fatty-acid metabolism (HP:0004359)1.96813414
63Increased serum lactate (HP:0002151)1.95955716
64Acute necrotizing encephalopathy (HP:0006965)1.92943779
65Glycosuria (HP:0003076)1.92714118
66Abnormality of urine glucose concentration (HP:0011016)1.92714118
67Pulmonary fibrosis (HP:0002206)1.92025668
68Reduced antithrombin III activity (HP:0001976)1.91478700
69Abnormality of the anterior horn cell (HP:0006802)1.90915383
70Degeneration of anterior horn cells (HP:0002398)1.90915383
71Methylmalonic aciduria (HP:0012120)1.89539931
72Hypoproteinemia (HP:0003075)1.89530411
73Increased IgM level (HP:0003496)1.89012377
74Large for gestational age (HP:0001520)1.89001494
75Amniotic constriction ring (HP:0009775)1.87508477
76Abnormality of placental membranes (HP:0011409)1.87508477
77Abnormal mitochondria in muscle tissue (HP:0008316)1.87423828
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.87033592
79Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84847833
80Respiratory difficulties (HP:0002880)1.84113809
81Conical tooth (HP:0000698)1.82578634
82Adrenal hypoplasia (HP:0000835)1.82430932
83Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81811455
84Abnormality of the labia minora (HP:0012880)1.81175492
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80258268
86Dicarboxylic aciduria (HP:0003215)1.79704453
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79704453
88Abnormal spermatogenesis (HP:0008669)1.78802920
89Abnormality of serum amino acid levels (HP:0003112)1.78595055
90Asplenia (HP:0001746)1.78455704
91Neutropenia (HP:0001875)1.76521310
92Pulmonary infiltrates (HP:0002113)1.75891661
93Vasculitis (HP:0002633)1.75195079
94Absent thumb (HP:0009777)1.74361875
95Optic disc pallor (HP:0000543)1.73773719
96Clubbing of toes (HP:0100760)1.71814563
97Xerostomia (HP:0000217)1.71789616
98Abnormality of the ileum (HP:0001549)1.71655698
99Hyperphosphaturia (HP:0003109)1.71655588
100Autoimmune hemolytic anemia (HP:0001890)1.70253593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.17009177
2MAP4K23.29577483
3TESK22.91565129
4KDR2.78063306
5BCKDK2.67000302
6TLK12.51718862
7GRK62.14991417
8ZAK2.04658250
9GRK72.03190840
10NUAK11.96711517
11VRK21.93510354
12MAP3K141.87133572
13BUB11.83603037
14VRK11.76613264
15TAOK31.68348675
16EIF2AK31.68228098
17EIF2AK21.62511773
18MAP2K21.50215050
19EIF2AK11.44853304
20TRIM281.43126206
21ERBB31.40877140
22GRK51.37773627
23ITK1.37439507
24MST41.35512111
25ADRBK21.34688808
26MAP3K121.33389256
27STK101.31049430
28OXSR11.27001057
29STK391.17822868
30SYK1.16966421
31CSF1R1.15489791
32IKBKE1.11407488
33ACVR1B1.07839999
34LIMK11.07660025
35MOS1.07139448
36BMPR1B1.06054915
37MKNK11.03430176
38GRK11.03416894
39TESK11.00731843
40CSNK1G30.97500798
41KIT0.97073723
42TGFBR20.96898609
43MUSK0.95777138
44IGF1R0.93104702
45PDK20.90130739
46FES0.89359720
47FRK0.85163447
48PLK20.85146425
49WNK30.84588735
50CSNK1G20.80959560
51DAPK10.79193840
52PLK40.78540556
53STK160.78160607
54IKBKB0.77699961
55SRPK10.74431014
56WNK40.73046927
57TBK10.72783142
58BCR0.70300189
59CSNK1A1L0.68438765
60MATK0.67425046
61MKNK20.66278206
62PLK30.65962587
63WEE10.65719837
64TEC0.65180563
65CSNK1G10.65129378
66BRSK20.64255406
67NEK20.63633897
68BMPR20.61862901
69LYN0.59045083
70HCK0.59037182
71NEK10.58345477
72ADRBK10.56838393
73RPS6KA50.55903949
74PASK0.54297363
75PHKG10.53314821
76PHKG20.53314821
77INSRR0.53160733
78RPS6KA40.51987136
79LCK0.51502871
80RIPK40.51381901
81JAK10.51125627
82PIM10.47738726
83ATR0.47605996
84MYLK0.46770161
85TIE10.46349614
86MAPK130.43293161
87PRKCQ0.42743680
88CAMKK20.42373444
89PRKCE0.41981375
90AURKB0.40629497
91MAP2K60.39157972
92MAPKAPK20.37871007
93MAPK70.36377381
94STK40.33492334
95CDK30.33274819
96CDC70.33127931
97AURKA0.33085092
98TSSK60.32157298
99TRPM70.31578223
100TAF10.30439558

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.67478581
2Proteasome_Homo sapiens_hsa030504.48396397
3Primary immunodeficiency_Homo sapiens_hsa053402.83264080
4Graft-versus-host disease_Homo sapiens_hsa053322.22659922
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.21022295
6Non-homologous end-joining_Homo sapiens_hsa034502.19036693
7Protein export_Homo sapiens_hsa030602.17670958
8Antigen processing and presentation_Homo sapiens_hsa046122.09983568
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02608983
10Type I diabetes mellitus_Homo sapiens_hsa049401.95855950
11Asthma_Homo sapiens_hsa053101.95291033
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94234058
13Allograft rejection_Homo sapiens_hsa053301.93601968
14Autoimmune thyroid disease_Homo sapiens_hsa053201.85059632
15Oxidative phosphorylation_Homo sapiens_hsa001901.84644165
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73520782
17Fanconi anemia pathway_Homo sapiens_hsa034601.71205657
18RNA degradation_Homo sapiens_hsa030181.69812748
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68738755
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65052281
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61685190
22Parkinsons disease_Homo sapiens_hsa050121.59418912
23RNA polymerase_Homo sapiens_hsa030201.59086568
24Homologous recombination_Homo sapiens_hsa034401.51371796
25DNA replication_Homo sapiens_hsa030301.50151951
26One carbon pool by folate_Homo sapiens_hsa006701.49617142
27Mismatch repair_Homo sapiens_hsa034301.48767245
28Tryptophan metabolism_Homo sapiens_hsa003801.37670952
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29878345
30Phototransduction_Homo sapiens_hsa047441.28774746
31Systemic lupus erythematosus_Homo sapiens_hsa053221.27527158
32Rheumatoid arthritis_Homo sapiens_hsa053231.25428383
33Sulfur metabolism_Homo sapiens_hsa009201.19614533
34Nucleotide excision repair_Homo sapiens_hsa034201.17411356
35Purine metabolism_Homo sapiens_hsa002301.16611210
36Peroxisome_Homo sapiens_hsa041461.15449399
37Butanoate metabolism_Homo sapiens_hsa006501.10680678
38Pyrimidine metabolism_Homo sapiens_hsa002401.10212033
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09579309
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.09368662
41Basal transcription factors_Homo sapiens_hsa030221.08851388
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07239230
43Hematopoietic cell lineage_Homo sapiens_hsa046401.06529823
44Caffeine metabolism_Homo sapiens_hsa002321.06418649
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06160408
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.04888193
47Base excision repair_Homo sapiens_hsa034100.98516178
48Selenocompound metabolism_Homo sapiens_hsa004500.98149202
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97525010
50Propanoate metabolism_Homo sapiens_hsa006400.96282339
51Spliceosome_Homo sapiens_hsa030400.96246949
52Alzheimers disease_Homo sapiens_hsa050100.95011589
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90467919
54Fatty acid elongation_Homo sapiens_hsa000620.89937464
55Huntingtons disease_Homo sapiens_hsa050160.85172818
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84975715
57Viral myocarditis_Homo sapiens_hsa054160.82286257
58Nitrogen metabolism_Homo sapiens_hsa009100.78180660
59Regulation of autophagy_Homo sapiens_hsa041400.77974622
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.75897718
61Phenylalanine metabolism_Homo sapiens_hsa003600.74519440
62RNA transport_Homo sapiens_hsa030130.73855006
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72159361
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.70244380
65Herpes simplex infection_Homo sapiens_hsa051680.68113800
66Shigellosis_Homo sapiens_hsa051310.67465422
67Linoleic acid metabolism_Homo sapiens_hsa005910.67178178
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66286650
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59682132
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58977368
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56626103
72Epstein-Barr virus infection_Homo sapiens_hsa051690.54794255
73Arachidonic acid metabolism_Homo sapiens_hsa005900.51855139
74Retinol metabolism_Homo sapiens_hsa008300.51492312
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50467921
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49174223
77Legionellosis_Homo sapiens_hsa051340.47182416
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46138502
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.45114180
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43748643
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42977927
82Collecting duct acid secretion_Homo sapiens_hsa049660.42782740
83Chemical carcinogenesis_Homo sapiens_hsa052040.42641221
84Alcoholism_Homo sapiens_hsa050340.42206201
85Measles_Homo sapiens_hsa051620.41531461
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40570623
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40169300
88Taste transduction_Homo sapiens_hsa047420.39069458
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37556445
90Metabolic pathways_Homo sapiens_hsa011000.37433198
91Olfactory transduction_Homo sapiens_hsa047400.35393875
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33652575
93Cardiac muscle contraction_Homo sapiens_hsa042600.31436108
94Steroid biosynthesis_Homo sapiens_hsa001000.30979494
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30883810
96Oocyte meiosis_Homo sapiens_hsa041140.30611964
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30080884
98Leishmaniasis_Homo sapiens_hsa051400.26927278
99Pyruvate metabolism_Homo sapiens_hsa006200.25597497
100Pentose phosphate pathway_Homo sapiens_hsa000300.23611999

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