RBBP4P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of prostaglandin secretion (GO:0032308)6.05590867
2cellular response to interleukin-15 (GO:0071350)5.77307720
3response to pheromone (GO:0019236)5.45069843
4negative regulation of cell killing (GO:0031342)5.30165212
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30165212
6regulation of prostaglandin secretion (GO:0032306)4.92399735
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.59389733
8regulation of germinal center formation (GO:0002634)4.27060766
9negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.23914580
10sleep (GO:0030431)4.19691206
11response to interleukin-15 (GO:0070672)4.17349030
12mitochondrial calcium ion transport (GO:0006851)4.12996826
13interferon-gamma production (GO:0032609)4.12142187
14regulation of T cell mediated cytotoxicity (GO:0001914)4.10065948
15positive regulation of icosanoid secretion (GO:0032305)4.07434760
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95095563
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95095563
18positive regulation of heat generation (GO:0031652)3.90432554
19positive regulation of fatty acid transport (GO:2000193)3.90261737
20regulation of memory T cell differentiation (GO:0043380)3.90106686
21rRNA catabolic process (GO:0016075)3.88136886
22regulation of mitotic spindle checkpoint (GO:1903504)3.83308455
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.83308455
24DNA deamination (GO:0045006)3.83034782
25protein-cofactor linkage (GO:0018065)3.82569318
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.80159299
27peptidyl-threonine dephosphorylation (GO:0035970)3.77194753
28cell wall macromolecule catabolic process (GO:0016998)3.75162030
29positive regulation of osteoclast differentiation (GO:0045672)3.72698460
30lymph node development (GO:0048535)3.71793472
31plasma membrane fusion (GO:0045026)3.68686582
32regulation of gamma-delta T cell differentiation (GO:0045586)3.64793704
33regulation of fever generation (GO:0031620)3.63732575
34water-soluble vitamin biosynthetic process (GO:0042364)3.62768202
35positive regulation of defense response to virus by host (GO:0002230)3.50365237
36base-excision repair, AP site formation (GO:0006285)3.43497985
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41666703
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.40853429
39sequestering of actin monomers (GO:0042989)3.40389308
40adenosine metabolic process (GO:0046085)3.34757016
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.27339179
42negative regulation of DNA-templated transcription, elongation (GO:0032785)3.24178402
43actin nucleation (GO:0045010)3.23447208
44tolerance induction (GO:0002507)3.18388164
45positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.17163488
46cell wall macromolecule metabolic process (GO:0044036)3.12805347
47male sex determination (GO:0030238)3.11570390
48mannosylation (GO:0097502)3.09157166
49response to interferon-beta (GO:0035456)3.08425571
50regulation of icosanoid secretion (GO:0032303)3.06735779
51bone resorption (GO:0045453)3.05365941
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03487544
53mast cell activation (GO:0045576)3.03374544
54positive regulation of T cell mediated immunity (GO:0002711)2.99995728
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.99102964
56somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99102964
57positive regulation of oligodendrocyte differentiation (GO:0048714)2.98274700
58tumor necrosis factor-mediated signaling pathway (GO:0033209)2.98109759
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96598163
60isotype switching (GO:0045190)2.96598163
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96598163
62regulation of immunoglobulin secretion (GO:0051023)2.94869635
63endoderm formation (GO:0001706)2.93060234
64regulation of heat generation (GO:0031650)2.92821630
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.91855839
66regulation of cell killing (GO:0031341)2.91022523
67positive regulation of T cell cytokine production (GO:0002726)2.90472328
68negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.89358521
69regulation of gamma-delta T cell activation (GO:0046643)2.87504605
70cellular defense response (GO:0006968)2.87146114
71mitotic cell cycle arrest (GO:0071850)2.86539291
72preassembly of GPI anchor in ER membrane (GO:0016254)2.84554755
73mammary gland alveolus development (GO:0060749)2.82442278
74interleukin-1-mediated signaling pathway (GO:0070498)2.82338109
75protein deneddylation (GO:0000338)2.78165483
76kynurenine metabolic process (GO:0070189)2.77911611
77regulation of defense response to virus by host (GO:0050691)2.77029439
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76871071
79cytidine deamination (GO:0009972)2.72939325
80cytidine metabolic process (GO:0046087)2.72939325
81cytidine catabolic process (GO:0006216)2.72939325
82peptidyl-histidine modification (GO:0018202)2.72684804
83protein localization to cilium (GO:0061512)2.72614710
84regulation of interleukin-8 secretion (GO:2000482)2.72308147
85regulation of hexokinase activity (GO:1903299)2.72279568
86regulation of glucokinase activity (GO:0033131)2.72279568
87Peyers patch development (GO:0048541)2.70796123
88mucosal-associated lymphoid tissue development (GO:0048537)2.70796123
89alpha-beta T cell activation (GO:0046631)2.70776076
90regulation of T cell mediated immunity (GO:0002709)2.69785913
91mast cell activation involved in immune response (GO:0002279)2.65721382
92mast cell degranulation (GO:0043303)2.65721382
93negative regulation of thymocyte apoptotic process (GO:0070244)2.63576022
94regulation of activation of Janus kinase activity (GO:0010533)2.63201262
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62751262
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62144683
97nucleotide transmembrane transport (GO:1901679)2.60097232
98alpha-beta T cell differentiation (GO:0046632)2.58225695
99positive regulation of interleukin-8 secretion (GO:2000484)2.56907716
100positive regulation of cell killing (GO:0031343)2.56335272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.89965971
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.73194004
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50565053
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26903071
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10098450
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.09392589
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86901391
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86680515
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.81022029
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80903785
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.71998792
12VDR_23849224_ChIP-Seq_CD4+_Human2.71875515
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60175385
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.45632778
15IGF1R_20145208_ChIP-Seq_DFB_Human2.32146792
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30089182
17ZNF274_21170338_ChIP-Seq_K562_Hela2.28884148
18IRF1_19129219_ChIP-ChIP_H3396_Human2.22135980
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.19780510
20VDR_22108803_ChIP-Seq_LS180_Human2.15726848
21FOXP3_21729870_ChIP-Seq_TREG_Human2.13499266
22MYC_18940864_ChIP-ChIP_HL60_Human2.04007906
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94771378
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91202393
25ELK1_19687146_ChIP-ChIP_HELA_Human1.88528520
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85945906
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85601797
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83457809
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83407732
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81480611
31RUNX_20019798_ChIP-Seq_JUKART_Human1.80241597
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.65932176
33GATA3_26560356_Chip-Seq_TH2_Human1.61669776
34TAF15_26573619_Chip-Seq_HEK293_Human1.58617246
35AR_20517297_ChIP-Seq_VCAP_Human1.55849890
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55648862
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55311546
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.53926841
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46596341
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45975945
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.41725533
42MYB_26560356_Chip-Seq_TH2_Human1.39236301
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38323133
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37587310
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33806631
46ER_23166858_ChIP-Seq_MCF-7_Human1.31248345
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26574379
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25787668
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24879644
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.24879644
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23677072
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21012478
53TP53_22573176_ChIP-Seq_HFKS_Human1.20953256
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20309369
55EWS_26573619_Chip-Seq_HEK293_Human1.20124405
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19503432
57STAT1_20625510_ChIP-Seq_HELA_Human1.19460659
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18227113
59CBP_20019798_ChIP-Seq_JUKART_Human1.18227113
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17916365
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17667151
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.17287507
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.17030566
64CIITA_25753668_ChIP-Seq_RAJI_Human1.16767213
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15861710
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.15714767
67GATA3_27048872_Chip-Seq_THYMUS_Human1.14888335
68GABP_19822575_ChIP-Seq_HepG2_Human1.09851044
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09426963
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08834922
71HOXB7_26014856_ChIP-Seq_BT474_Human1.08018398
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06447115
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05623548
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04251494
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02973850
76MYC_19829295_ChIP-Seq_ESCs_Human1.01985757
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01786423
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01306366
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00415184
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99528117
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.99132294
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98470386
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97835999
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.97409604
85NCOR_22424771_ChIP-Seq_293T_Human0.97309386
86SOX2_19829295_ChIP-Seq_ESCs_Human0.95557318
87NANOG_19829295_ChIP-Seq_ESCs_Human0.95557318
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95286094
89STAT3_18555785_Chip-Seq_ESCs_Mouse0.94242136
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93350991
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93185126
92DCP1A_22483619_ChIP-Seq_HELA_Human0.92754360
93SPI1_23547873_ChIP-Seq_NB4_Human0.92463339
94NANOG_20526341_ChIP-Seq_ESCs_Human0.92081458
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91494534
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90775741
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90689448
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.89369894
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88731287
100GATA3_26560356_Chip-Seq_TH1_Human0.87824242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.93060436
2MP0004147_increased_porphyrin_level3.49789940
3MP0000685_abnormal_immune_system3.36169168
4MP0003195_calcinosis3.23098389
5MP0003724_increased_susceptibility_to2.68697296
6MP0001835_abnormal_antigen_presentation2.68193909
7MP0002166_altered_tumor_susceptibility2.66508075
8MP0006072_abnormal_retinal_apoptosis2.63867665
9MP0003763_abnormal_thymus_physiology2.40533835
10MP0003436_decreased_susceptibility_to2.39559205
11MP0009785_altered_susceptibility_to2.38030048
12MP0002102_abnormal_ear_morphology2.25806122
13MP0005000_abnormal_immune_tolerance2.23600960
14MP0002006_tumorigenesis2.21473642
15MP0000465_gastrointestinal_hemorrhage2.17063973
16MP0002148_abnormal_hypersensitivity_rea2.14013161
17MP0005084_abnormal_gallbladder_morpholo2.10899871
18MP0003011_delayed_dark_adaptation1.99388858
19MP0003786_premature_aging1.95842416
20MP0005075_abnormal_melanosome_morpholog1.87637963
21MP0004885_abnormal_endolymph1.86913819
22MP0002723_abnormal_immune_serum1.80211937
23MP0001800_abnormal_humoral_immune1.78984303
24MP0005387_immune_system_phenotype1.78720121
25MP0001790_abnormal_immune_system1.78720121
26MP0004043_abnormal_pH_regulation1.76457395
27MP0008872_abnormal_physiological_respon1.73119792
28MP0001986_abnormal_taste_sensitivity1.72654999
29MP0001919_abnormal_reproductive_system1.69244759
30MP0001819_abnormal_immune_cell1.67045113
31MP0002420_abnormal_adaptive_immunity1.66325087
32MP0003252_abnormal_bile_duct1.65293121
33MP0002405_respiratory_system_inflammati1.56281549
34MP0002452_abnormal_antigen_presenting1.53196084
35MP0005379_endocrine/exocrine_gland_phen1.48499125
36MP0001501_abnormal_sleep_pattern1.46880698
37MP0002876_abnormal_thyroid_physiology1.46368592
38MP0005645_abnormal_hypothalamus_physiol1.45022156
39MP0008058_abnormal_DNA_repair1.42226350
40MP0000689_abnormal_spleen_morphology1.42180834
41MP0001533_abnormal_skeleton_physiology1.40784852
42MP0002933_joint_inflammation1.39823814
43MP0005253_abnormal_eye_physiology1.38113619
44MP0002398_abnormal_bone_marrow1.35524030
45MP0003878_abnormal_ear_physiology1.35050427
46MP0005377_hearing/vestibular/ear_phenot1.35050427
47MP0010155_abnormal_intestine_physiology1.32248909
48MP0009764_decreased_sensitivity_to1.30752850
49MP0004142_abnormal_muscle_tone1.30455957
50MP0002234_abnormal_pharynx_morphology1.30394459
51MP0002419_abnormal_innate_immunity1.28098865
52MP0001853_heart_inflammation1.27804022
53MP0000716_abnormal_immune_system1.26001364
54MP0003646_muscle_fatigue1.25184424
55MP0002722_abnormal_immune_system1.24796711
56MP0005646_abnormal_pituitary_gland1.21277714
57MP0005025_abnormal_response_to1.21006126
58MP0002009_preneoplasia1.19676369
59MP0003866_abnormal_defecation1.18759497
60MP0000372_irregular_coat_pigmentation1.17413852
61MP0005551_abnormal_eye_electrophysiolog1.16896314
62MP0000703_abnormal_thymus_morphology1.12474711
63MP0003283_abnormal_digestive_organ1.11158616
64MP0008995_early_reproductive_senescence1.09414867
65MP0008875_abnormal_xenobiotic_pharmacok1.02927036
66MP0005389_reproductive_system_phenotype1.02305353
67MP0001845_abnormal_inflammatory_respons1.01777340
68MP0004145_abnormal_muscle_electrophysio1.01279603
69MP0001542_abnormal_bone_strength0.94906718
70MP0006082_CNS_inflammation0.93568106
71MP0003638_abnormal_response/metabolism_0.93105028
72MP0002429_abnormal_blood_cell0.91745841
73MP0008877_abnormal_DNA_methylation0.89911154
74MP0009046_muscle_twitch0.87254913
75MP0001984_abnormal_olfaction0.86574816
76MP0005167_abnormal_blood-brain_barrier0.85447442
77MP0000639_abnormal_adrenal_gland0.82925474
78MP0004947_skin_inflammation0.81456986
79MP0010094_abnormal_chromosome_stability0.81170129
80MP0005410_abnormal_fertilization0.79888280
81MP0002272_abnormal_nervous_system0.79341145
82MP0001348_abnormal_lacrimal_gland0.77710633
83MP0002138_abnormal_hepatobiliary_system0.75838831
84MP0001968_abnormal_touch/_nociception0.73900596
85MP0001881_abnormal_mammary_gland0.73326769
86MP0003656_abnormal_erythrocyte_physiolo0.71445910
87MP0002095_abnormal_skin_pigmentation0.70254165
88MP0002998_abnormal_bone_remodeling0.69484226
89MP0008469_abnormal_protein_level0.68932249
90MP0002736_abnormal_nociception_after0.67165497
91MP0001764_abnormal_homeostasis0.65369407
92MP0006035_abnormal_mitochondrial_morpho0.64881362
93MP0005390_skeleton_phenotype0.64272494
94MP0003119_abnormal_digestive_system0.62354527
95MP0005332_abnormal_amino_acid0.62345217
96MP0006054_spinal_hemorrhage0.61900855
97MP0008961_abnormal_basal_metabolism0.60275624
98MP0002928_abnormal_bile_duct0.59038083
99MP0009765_abnormal_xenobiotic_induced0.56965899
100MP0006036_abnormal_mitochondrial_physio0.56665190

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.87926741
2Renal cortical cysts (HP:0000803)4.25166181
3Severe combined immunodeficiency (HP:0004430)3.95038499
4Hyperalaninemia (HP:0003348)3.83180934
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.83180934
6Abnormality of alanine metabolism (HP:0010916)3.83180934
7Abnormality of the renal cortex (HP:0011035)3.66071488
8T lymphocytopenia (HP:0005403)3.64531664
9Stomatitis (HP:0010280)3.64313039
10Abnormality of T cell number (HP:0011839)3.46418044
11Mesomelia (HP:0003027)3.43013072
12Abnormality of T cells (HP:0002843)3.36203521
13Elevated erythrocyte sedimentation rate (HP:0003565)3.34712252
143-Methylglutaconic aciduria (HP:0003535)3.30913923
15Abnormality of T cell physiology (HP:0011840)3.29631137
16Increased density of long bones (HP:0006392)3.16819293
17Combined immunodeficiency (HP:0005387)3.09603570
18Large for gestational age (HP:0001520)3.02660046
19Persistence of primary teeth (HP:0006335)2.81556552
20Thyroiditis (HP:0100646)2.71004849
21Abnormality of eosinophils (HP:0001879)2.68319129
22Retrobulbar optic neuritis (HP:0100654)2.66292966
23Optic neuritis (HP:0100653)2.66292966
24Abolished electroretinogram (ERG) (HP:0000550)2.64831030
25Chronic mucocutaneous candidiasis (HP:0002728)2.63624368
26Recurrent cutaneous fungal infections (HP:0011370)2.63624368
27Median cleft lip (HP:0000161)2.62082044
28Renal salt wasting (HP:0000127)2.58096282
29Pancreatic cysts (HP:0001737)2.55893246
30Increased hepatocellular lipid droplets (HP:0006565)2.52256228
31Congenital stationary night blindness (HP:0007642)2.47895648
32Aplasia/hypoplasia of the uterus (HP:0008684)2.47804001
33Methylmalonic acidemia (HP:0002912)2.47117202
34Abnormal sex determination (HP:0012244)2.47006593
35Sex reversal (HP:0012245)2.47006593
36Metabolic alkalosis (HP:0200114)2.46210017
37Lipid accumulation in hepatocytes (HP:0006561)2.45985308
38Premature loss of primary teeth (HP:0006323)2.42793032
39Conical tooth (HP:0000698)2.39731595
40Duplicated collecting system (HP:0000081)2.39102987
41Congenital, generalized hypertrichosis (HP:0004540)2.38726218
42Hypokalemic alkalosis (HP:0001949)2.34939338
43Gonadal dysgenesis (HP:0000133)2.32771286
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.31422205
45Large eyes (HP:0001090)2.31072093
46Myositis (HP:0100614)2.30238699
47Abnormality of the renal collecting system (HP:0004742)2.28899080
48Brittle hair (HP:0002299)2.26933483
49Adrenal hypoplasia (HP:0000835)2.26861714
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.22939218
51Chronic diarrhea (HP:0002028)2.22730274
52Asplenia (HP:0001746)2.21849828
53Volvulus (HP:0002580)2.19913885
54Arthropathy (HP:0003040)2.19411731
55Abnormality of the prostate (HP:0008775)2.13939841
56Pustule (HP:0200039)2.11004515
57Panhypogammaglobulinemia (HP:0003139)2.10446453
58Encephalitis (HP:0002383)2.09418387
59Abnormality of the renal medulla (HP:0100957)2.09265594
60Type II lissencephaly (HP:0007260)2.08315386
61Nephronophthisis (HP:0000090)2.06052158
62Prostate neoplasm (HP:0100787)2.04982147
63Molar tooth sign on MRI (HP:0002419)2.04584732
64Abnormality of midbrain morphology (HP:0002418)2.04584732
65Mitochondrial inheritance (HP:0001427)2.03615852
66Type I transferrin isoform profile (HP:0003642)2.01959987
67Increased CSF lactate (HP:0002490)2.01849146
68Postaxial foot polydactyly (HP:0001830)1.99799955
69Orchitis (HP:0100796)1.99172241
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98649872
71Abnormal protein N-linked glycosylation (HP:0012347)1.98649872
72Abnormal protein glycosylation (HP:0012346)1.98649872
73Abnormal glycosylation (HP:0012345)1.98649872
74Pulmonary fibrosis (HP:0002206)1.97165781
75Keratoconjunctivitis (HP:0001096)1.96832697
76Rhinitis (HP:0012384)1.93824432
77Pancytopenia (HP:0001876)1.92911151
78Neutropenia (HP:0001875)1.89666286
79Hypoplasia of the uterus (HP:0000013)1.89436274
80Stomach cancer (HP:0012126)1.88913030
81Methylmalonic aciduria (HP:0012120)1.88664274
82Pulmonary infiltrates (HP:0002113)1.88182061
83Increased serum lactate (HP:0002151)1.87887201
84IgM deficiency (HP:0002850)1.86579320
85Cerebellar dysplasia (HP:0007033)1.84220818
86True hermaphroditism (HP:0010459)1.82485685
87Homocystinuria (HP:0002156)1.80668580
88Abnormality of homocysteine metabolism (HP:0010919)1.80668580
89Retinal dysplasia (HP:0007973)1.79655696
90Hepatocellular necrosis (HP:0001404)1.78961599
91Abnormality of the ileum (HP:0001549)1.78013133
92Clubbing of toes (HP:0100760)1.77542025
93Attenuation of retinal blood vessels (HP:0007843)1.76848756
94Autoimmune hemolytic anemia (HP:0001890)1.76314742
95Anorexia (HP:0002039)1.75953524
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73697902
97Lissencephaly (HP:0001339)1.73091990
98Alkalosis (HP:0001948)1.73008617
99Tetany (HP:0001281)1.72827090
100Microretrognathia (HP:0000308)1.72219079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.05989630
2FES4.58679015
3GRK63.97669856
4TAOK32.92798435
5TESK22.85202579
6BCKDK2.76190584
7MAP4K22.64218538
8FER2.62997211
9MAP2K22.49094857
10TLK12.48009414
11MAP3K142.45274366
12MUSK2.42695688
13ZAK2.14577820
14NUAK11.97957573
15VRK21.90878553
16MST41.77285400
17KDR1.49472995
18KIT1.48184967
19TRIM281.47492636
20ADRBK21.44131782
21IKBKE1.37949421
22EIF2AK21.37713657
23JAK11.27183860
24GRK71.24801416
25ITK1.24613769
26CSNK1G31.18794435
27GRK11.15520737
28IKBKB1.14749205
29STK161.03370117
30GRK51.01858708
31TBK11.01491512
32CSNK1G21.01281521
33VRK11.00565541
34PRKD30.96971591
35TEC0.95111936
36CSNK1A1L0.93839062
37STK100.91582283
38CSNK1G10.85448793
39PASK0.83917085
40BUB10.77314647
41PRKCE0.77309597
42PRKCQ0.76662474
43CSF1R0.76336895
44BCR0.75314670
45IGF1R0.75016560
46PIM10.72555096
47MATK0.72336099
48BMPR1B0.71195120
49STK390.71036674
50ZAP700.70943344
51SYK0.69250264
52ADRBK10.68243361
53ERBB30.68150999
54WNK40.67435332
55PDK20.65903201
56BTK0.65854927
57EIF2AK30.65702472
58MAP3K120.64262065
59MAP4K10.63433702
60LIMK10.63424227
61CHUK0.60884467
62RPS6KA40.57958850
63CAMKK20.57200456
64PINK10.55241651
65EIF2AK10.53598181
66LCK0.52969095
67PLK20.52904949
68JAK30.52844005
69CAMK10.50198069
70INSRR0.50072845
71DAPK10.50071777
72RPS6KA50.49268847
73WNK30.49239058
74LYN0.47541480
75SRPK10.45272489
76MAPK110.44554853
77HCK0.44416690
78FRK0.43451450
79OXSR10.42769212
80TESK10.42425325
81CAMKK10.41602661
82CDK30.40749168
83ATR0.39756340
84TYK20.39703277
85TIE10.36891880
86PRKCD0.35869934
87MAPK130.33924774
88PKN10.33219768
89TAF10.33128496
90PLK30.33064504
91TGFBR20.31757196
92EGFR0.30914727
93MAP2K60.28842478
94CSNK1A10.27418867
95PRKCA0.27130177
96TGFBR10.26728052
97ABL10.24901303
98MYLK0.24438854
99PHKG20.21557280
100PHKG10.21557280

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.15756080
2Proteasome_Homo sapiens_hsa030503.66193481
3Primary immunodeficiency_Homo sapiens_hsa053402.76696374
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14010830
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.03845539
6Caffeine metabolism_Homo sapiens_hsa002322.01804323
7Oxidative phosphorylation_Homo sapiens_hsa001901.92666200
8Phototransduction_Homo sapiens_hsa047441.90732972
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88543687
10Sulfur metabolism_Homo sapiens_hsa009201.74188266
11Tryptophan metabolism_Homo sapiens_hsa003801.73519186
12RNA polymerase_Homo sapiens_hsa030201.71569481
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.71421861
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68897723
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.67324221
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.65539695
17RNA degradation_Homo sapiens_hsa030181.64134875
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64067870
19Phenylalanine metabolism_Homo sapiens_hsa003601.60561809
20Fanconi anemia pathway_Homo sapiens_hsa034601.58675398
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58249314
22Antigen processing and presentation_Homo sapiens_hsa046121.57017276
23Homologous recombination_Homo sapiens_hsa034401.56822108
24Basal transcription factors_Homo sapiens_hsa030221.55608172
25Mismatch repair_Homo sapiens_hsa034301.53423636
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51818183
27Protein export_Homo sapiens_hsa030601.48768815
28Graft-versus-host disease_Homo sapiens_hsa053321.47902970
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41187903
30Parkinsons disease_Homo sapiens_hsa050121.38203135
31Rheumatoid arthritis_Homo sapiens_hsa053231.32297695
32Nitrogen metabolism_Homo sapiens_hsa009101.29618851
33Base excision repair_Homo sapiens_hsa034101.24621710
34Non-homologous end-joining_Homo sapiens_hsa034501.19658999
35Peroxisome_Homo sapiens_hsa041461.19476905
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17731042
37Allograft rejection_Homo sapiens_hsa053301.15223513
38Collecting duct acid secretion_Homo sapiens_hsa049661.10719859
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10311174
40Hematopoietic cell lineage_Homo sapiens_hsa046401.08490499
41Autoimmune thyroid disease_Homo sapiens_hsa053201.08351755
42Type I diabetes mellitus_Homo sapiens_hsa049401.05633409
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02687115
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02343044
45Fatty acid elongation_Homo sapiens_hsa000620.96681530
46One carbon pool by folate_Homo sapiens_hsa006700.96211437
47Retinol metabolism_Homo sapiens_hsa008300.95117562
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.95093218
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94279697
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93931134
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93726958
52Purine metabolism_Homo sapiens_hsa002300.92992837
53Pyrimidine metabolism_Homo sapiens_hsa002400.83203504
54Chemical carcinogenesis_Homo sapiens_hsa052040.82761184
55Linoleic acid metabolism_Homo sapiens_hsa005910.80965935
56Selenocompound metabolism_Homo sapiens_hsa004500.80609574
57RNA transport_Homo sapiens_hsa030130.80447862
58Herpes simplex infection_Homo sapiens_hsa051680.80317887
59Circadian rhythm_Homo sapiens_hsa047100.80072068
60Spliceosome_Homo sapiens_hsa030400.76686847
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76665318
62Alzheimers disease_Homo sapiens_hsa050100.75525418
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73325454
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.71624431
65Huntingtons disease_Homo sapiens_hsa050160.70583156
66Asthma_Homo sapiens_hsa053100.70141599
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69664697
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69157971
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67165186
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67073935
71Olfactory transduction_Homo sapiens_hsa047400.65509780
72Tyrosine metabolism_Homo sapiens_hsa003500.65504400
73Butanoate metabolism_Homo sapiens_hsa006500.57719263
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.57322456
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.56885913
76DNA replication_Homo sapiens_hsa030300.56867656
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56773674
78Ribosome_Homo sapiens_hsa030100.56182743
79Nucleotide excision repair_Homo sapiens_hsa034200.53701022
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53299943
81N-Glycan biosynthesis_Homo sapiens_hsa005100.53180779
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49995389
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49523201
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48165614
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47694987
86Regulation of autophagy_Homo sapiens_hsa041400.46580347
87Taste transduction_Homo sapiens_hsa047420.45794248
88Arachidonic acid metabolism_Homo sapiens_hsa005900.45241157
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43336394
90Measles_Homo sapiens_hsa051620.43179669
91Metabolic pathways_Homo sapiens_hsa011000.40340018
92GABAergic synapse_Homo sapiens_hsa047270.39277924
93Propanoate metabolism_Homo sapiens_hsa006400.38813876
94Epstein-Barr virus infection_Homo sapiens_hsa051690.37053712
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33982100
96Nicotine addiction_Homo sapiens_hsa050330.32769574
97Vitamin digestion and absorption_Homo sapiens_hsa049770.32633507
98Biosynthesis of amino acids_Homo sapiens_hsa012300.31063418
99Synaptic vesicle cycle_Homo sapiens_hsa047210.30270888
100Ether lipid metabolism_Homo sapiens_hsa005650.30037648

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »