RBBP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.53867104
2DNA unwinding involved in DNA replication (GO:0006268)5.50771451
3nuclear pore complex assembly (GO:0051292)5.42689914
4protein localization to kinetochore (GO:0034501)5.02141113
5folic acid-containing compound biosynthetic process (GO:0009396)4.95759097
6pre-miRNA processing (GO:0031054)4.92617487
7mitotic sister chromatid cohesion (GO:0007064)4.85268229
8mitotic nuclear envelope disassembly (GO:0007077)4.74928289
9negative regulation of histone methylation (GO:0031061)4.50559246
10membrane disassembly (GO:0030397)4.49585778
11nuclear envelope disassembly (GO:0051081)4.49585778
12mitotic chromosome condensation (GO:0007076)4.36748118
13IMP biosynthetic process (GO:0006188)4.34331734
14regulation of translational fidelity (GO:0006450)4.25907526
15DNA geometric change (GO:0032392)4.21987051
16DNA duplex unwinding (GO:0032508)4.21231504
17DNA replication initiation (GO:0006270)4.19719306
18DNA double-strand break processing (GO:0000729)4.16760643
19protein localization to chromosome, centromeric region (GO:0071459)4.12483026
20mitotic metaphase plate congression (GO:0007080)4.03441140
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.03335688
22sister chromatid segregation (GO:0000819)4.01057326
23pore complex assembly (GO:0046931)3.97376155
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.95643825
25IMP metabolic process (GO:0046040)3.95140781
26replication fork processing (GO:0031297)3.92462810
27synapsis (GO:0007129)3.90412110
28regulation of translational termination (GO:0006449)3.90198246
29DNA strand elongation involved in DNA replication (GO:0006271)3.89829269
30histone H2A monoubiquitination (GO:0035518)3.83914809
31mitotic sister chromatid segregation (GO:0000070)3.83371149
32regulation of histone H3-K9 methylation (GO:0051570)3.82954901
33regulation of sister chromatid cohesion (GO:0007063)3.81052134
34nucleobase biosynthetic process (GO:0046112)3.78957954
35metaphase plate congression (GO:0051310)3.78008044
36regulation of RNA export from nucleus (GO:0046831)3.76869615
37regulation of spindle organization (GO:0090224)3.73936321
38respiratory chain complex IV assembly (GO:0008535)3.73019693
39DNA strand elongation (GO:0022616)3.70665154
40proteasome assembly (GO:0043248)3.67915712
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66735518
42DNA deamination (GO:0045006)3.64398342
43piRNA metabolic process (GO:0034587)3.63407124
44DNA replication-dependent nucleosome assembly (GO:0006335)3.59274590
45DNA replication-dependent nucleosome organization (GO:0034723)3.59274590
46nuclear envelope organization (GO:0006998)3.58531748
47protein K6-linked ubiquitination (GO:0085020)3.56160667
48establishment of chromosome localization (GO:0051303)3.55151660
49regulation of meiosis I (GO:0060631)3.53735539
50regulation of mitotic spindle organization (GO:0060236)3.53594267
51water-soluble vitamin biosynthetic process (GO:0042364)3.52893498
52positive regulation of chromosome segregation (GO:0051984)3.51236715
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.51035965
54dosage compensation (GO:0007549)3.50940210
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.49967625
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.49967625
57attachment of spindle microtubules to kinetochore (GO:0008608)3.47536947
58lactate metabolic process (GO:0006089)3.43681630
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.41040470
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36494203
61ribosome assembly (GO:0042255)3.35490718
62resolution of meiotic recombination intermediates (GO:0000712)3.33887018
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33074149
64glucocorticoid receptor signaling pathway (GO:0042921)3.33049652
65regulation of gene silencing by RNA (GO:0060966)3.32280111
66regulation of posttranscriptional gene silencing (GO:0060147)3.32280111
67regulation of gene silencing by miRNA (GO:0060964)3.32280111
68cytochrome complex assembly (GO:0017004)3.30252468
69recombinational repair (GO:0000725)3.28778195
70double-strand break repair via homologous recombination (GO:0000724)3.28578403
71formation of translation preinitiation complex (GO:0001731)3.28125300
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27721252
73kinetochore organization (GO:0051383)3.25560957
74negative regulation of RNA splicing (GO:0033119)3.24866507
75regulation of centriole replication (GO:0046599)3.23157940
76DNA conformation change (GO:0071103)3.22397689
77DNA replication checkpoint (GO:0000076)3.19186856
78regulation of centrosome cycle (GO:0046605)3.18264366
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18034359
80isotype switching (GO:0045190)3.18034359
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18034359
82determination of adult lifespan (GO:0008340)3.17135055
83peptidyl-arginine omega-N-methylation (GO:0035247)3.16379050
84protein localization to chromosome (GO:0034502)3.16087730
85mitotic G1 DNA damage checkpoint (GO:0031571)3.14768791
86purine nucleobase biosynthetic process (GO:0009113)3.14357921
87chromatin remodeling at centromere (GO:0031055)3.14348573
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14131559
89regulation of mitotic spindle checkpoint (GO:1903504)3.14131559
90rRNA modification (GO:0000154)3.13891726
91regulation of chromosome segregation (GO:0051983)3.13609936
92keratinocyte development (GO:0003334)3.13454600
93regulation of nucleobase-containing compound transport (GO:0032239)3.13132003
94DNA topological change (GO:0006265)3.12805833
95telomere maintenance via semi-conservative replication (GO:0032201)3.11485576
96DNA catabolic process, exonucleolytic (GO:0000738)3.11204443
97protein complex biogenesis (GO:0070271)3.08962801
98RNA stabilization (GO:0043489)3.08954740
99mRNA stabilization (GO:0048255)3.08954740
100spindle assembly checkpoint (GO:0071173)3.07936274
101DNA methylation involved in gamete generation (GO:0043046)3.07821087
102negative regulation of chromosome segregation (GO:0051985)3.07496289
103CENP-A containing nucleosome assembly (GO:0034080)3.06966325
104mitotic spindle assembly checkpoint (GO:0007094)3.06644465
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.06284069
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06284069
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06284069
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05023601
109regulation of telomere maintenance via telomerase (GO:0032210)3.04328663
110gene silencing by RNA (GO:0031047)3.03987966
111mRNA transport (GO:0051028)3.03467120
112mitochondrial respiratory chain complex assembly (GO:0033108)3.03202343
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02495306
114histone exchange (GO:0043486)3.02461209
115negative regulation of mitotic sister chromatid separation (GO:2000816)3.00118550
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00118550
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00118550
118negative regulation of sister chromatid segregation (GO:0033046)3.00118550
119cullin deneddylation (GO:0010388)2.99915724
120peptidyl-arginine N-methylation (GO:0035246)2.99218927
121peptidyl-arginine methylation (GO:0018216)2.99218927
122response to pheromone (GO:0019236)2.99129123
123negative regulation of mRNA processing (GO:0050686)2.98203742
124regulation of DNA endoreduplication (GO:0032875)2.97985968
125histone H2A ubiquitination (GO:0033522)2.97906558
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96620384
127chromatin assembly or disassembly (GO:0006333)2.95712035
128nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.95345152
129postreplication repair (GO:0006301)2.94884061
130regulation of DNA damage checkpoint (GO:2000001)2.94858888
131microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.94286330
132mitotic recombination (GO:0006312)2.94016836
133negative regulation of DNA recombination (GO:0045910)2.93995693
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93263325
135spindle checkpoint (GO:0031577)2.93026094
136mRNA cleavage (GO:0006379)2.92638408
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92585614
138protein K11-linked deubiquitination (GO:0035871)2.91808067
139prenylation (GO:0097354)2.89697481
140protein prenylation (GO:0018342)2.89697481
141rRNA methylation (GO:0031167)2.88382256
142platelet dense granule organization (GO:0060155)2.88338977
143histone H2A acetylation (GO:0043968)2.83667852
144inositol phosphate catabolic process (GO:0071545)2.83046386
145protein deneddylation (GO:0000338)2.82950919
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77252166
147NADH dehydrogenase complex assembly (GO:0010257)2.76568586
148mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76568586
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.76568586
150somatic diversification of immunoglobulins (GO:0016445)2.76270600
151maturation of 5.8S rRNA (GO:0000460)2.75900024
152rRNA catabolic process (GO:0016075)2.75887355
153somatic recombination of immunoglobulin gene segments (GO:0016447)2.73903202
154pseudouridine synthesis (GO:0001522)2.73836301
155positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70771926
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70359296
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70359296
158non-recombinational repair (GO:0000726)2.69681773
159double-strand break repair via nonhomologous end joining (GO:0006303)2.69681773
160mitochondrial DNA replication (GO:0006264)2.69489661
161negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68671365
162L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68408405
163viral mRNA export from host cell nucleus (GO:0046784)2.68372518
164DNA-dependent DNA replication (GO:0006261)2.66989495
165sister chromatid cohesion (GO:0007062)2.66828471
166neural tube formation (GO:0001841)2.66466391
167establishment of protein localization to mitochondrial membrane (GO:0090151)2.64211345
168intra-S DNA damage checkpoint (GO:0031573)2.62728123
169regulation of mitochondrial translation (GO:0070129)2.62090221
170double-strand break repair (GO:0006302)2.61434564
171positive regulation of histone H3-K4 methylation (GO:0051571)2.61384216
172signal peptide processing (GO:0006465)2.59696575
173fucose catabolic process (GO:0019317)2.59135016
174L-fucose metabolic process (GO:0042354)2.59135016
175L-fucose catabolic process (GO:0042355)2.59135016
176signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58175469
177signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58175469
178signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58175469
179DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57868583
180transcription elongation from RNA polymerase III promoter (GO:0006385)2.55944380
181termination of RNA polymerase III transcription (GO:0006386)2.55944380
182anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55376785
183meiotic chromosome segregation (GO:0045132)2.54025750
184preassembly of GPI anchor in ER membrane (GO:0016254)2.53628684
185signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53500861
186intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53500861
187mannosylation (GO:0097502)2.53445327
188histone mRNA metabolic process (GO:0008334)2.53070175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.05282477
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99798618
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.49481187
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.40881976
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02668362
6MYC_22102868_ChIP-Seq_BL_Human2.86565133
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78282273
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75010064
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72041416
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69464341
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63310064
12VDR_22108803_ChIP-Seq_LS180_Human2.34777197
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30992030
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.29591951
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28199822
16AR_21909140_ChIP-Seq_LNCAP_Human2.19852004
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.19675943
18EWS_26573619_Chip-Seq_HEK293_Human2.11200341
19IGF1R_20145208_ChIP-Seq_DFB_Human2.08872374
20CIITA_25753668_ChIP-Seq_RAJI_Human2.07763541
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06444874
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02029561
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.01542822
24E2F7_22180533_ChIP-Seq_HELA_Human10.7097255
25FUS_26573619_Chip-Seq_HEK293_Human1.99321321
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93239290
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93140797
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.93075635
29* XRN2_22483619_ChIP-Seq_HELA_Human1.88469440
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88205842
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83193334
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82340316
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81786901
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81235563
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79197145
36MYC_18940864_ChIP-ChIP_HL60_Human1.76725738
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75334178
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73608554
39* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70437667
40* EST1_17652178_ChIP-ChIP_JURKAT_Human1.68705302
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67078087
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66907985
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.62052879
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61688968
45KDM5A_27292631_Chip-Seq_BREAST_Human1.61632573
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61064410
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59766604
48* ETS1_20019798_ChIP-Seq_JURKAT_Human1.59741415
49TAF15_26573619_Chip-Seq_HEK293_Human1.59219414
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59059053
51GBX2_23144817_ChIP-Seq_PC3_Human1.55794386
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55438447
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53215042
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53052693
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50687924
56P300_19829295_ChIP-Seq_ESCs_Human1.50254580
57* FOXP3_21729870_ChIP-Seq_TREG_Human1.50038365
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50028216
59VDR_23849224_ChIP-Seq_CD4+_Human1.48926605
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48123182
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45300529
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44182273
63* VDR_21846776_ChIP-Seq_THP-1_Human1.43828233
64IRF1_19129219_ChIP-ChIP_H3396_Human1.42588432
65* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40547893
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39298378
67TFEB_21752829_ChIP-Seq_HELA_Human1.38736347
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38082564
69GABP_19822575_ChIP-Seq_HepG2_Human1.36664748
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36450510
71ER_23166858_ChIP-Seq_MCF-7_Human1.35551376
72* EZH2_27294783_Chip-Seq_NPCs_Mouse1.35370277
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34167336
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32894871
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32324720
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31951154
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30091434
78* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29522771
79* TTF2_22483619_ChIP-Seq_HELA_Human1.28680676
80* NFE2_27457419_Chip-Seq_LIVER_Mouse1.27893914
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25236940
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24057192
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.23782154
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23032431
85* TP53_22573176_ChIP-Seq_HFKS_Human1.22475218
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20420523
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19820255
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17496242
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16640076
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16299667
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16299667
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16299667
93CBP_20019798_ChIP-Seq_JUKART_Human1.16286807
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16286807
95* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16232995
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15894645
97* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15870258
98* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14181581
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13649165
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12926354
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11341753
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10685496
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10550041
104* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10309584
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.09996550
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09537859
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09503799
108* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09071440
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08970308
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08141101
111SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07279485
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06915732
113* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06912864
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06475212
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.06475212
116* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06405358
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06313729
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06207129
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05736917
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05729774
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05465398
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05251151
123STAT3_23295773_ChIP-Seq_U87_Human1.04697502
124TCF7_22412390_ChIP-Seq_EML_Mouse1.04089583
125BCAT_22108803_ChIP-Seq_LS180_Human1.03972932
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03961163
127* ELK1_19687146_ChIP-ChIP_HELA_Human1.02995086
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02560262
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02368375
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02188384
131* DCP1A_22483619_ChIP-Seq_HELA_Human1.01985425
132* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01963615
133SMAD4_21799915_ChIP-Seq_A2780_Human1.01440165
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01084878
135* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01020679
136NANOG_19829295_ChIP-Seq_ESCs_Human1.00780994
137SOX2_19829295_ChIP-Seq_ESCs_Human1.00780994
138* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00775557
139CDX2_22108803_ChIP-Seq_LS180_Human0.99579586
140* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99122052
141TCF4_23295773_ChIP-Seq_U87_Human0.98663397
142* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98392179
143TCF4_22108803_ChIP-Seq_LS180_Human0.97815428
144KDM2B_26808549_Chip-Seq_DND41_Human0.97647820
145* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97328710
146* P53_22387025_ChIP-Seq_ESCs_Mouse0.97116285
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96198822
148* STAT3_18555785_Chip-Seq_ESCs_Mouse0.95713874
149* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95646117
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95630916
151CHD1_26751641_Chip-Seq_LNCaP_Human0.95521794
152* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94864412
153* UTX_26944678_Chip-Seq_JUKART_Human0.94722562
154* P300_18555785_Chip-Seq_ESCs_Mouse0.94522856
155HOXB7_26014856_ChIP-Seq_BT474_Human0.93953051
156* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93745203
157SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93508806
158* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92924314
159* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91805497
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91543786
161NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91198285
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90343233
163PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87273426
164MAF_26560356_Chip-Seq_TH1_Human0.87022231
165* MYB_26560356_Chip-Seq_TH1_Human0.86397082
166ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85857631
167* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82172214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.83703394
2MP0003111_abnormal_nucleus_morphology4.25005584
3MP0004957_abnormal_blastocyst_morpholog3.96193544
4MP0003077_abnormal_cell_cycle3.72738129
5MP0008057_abnormal_DNA_replication3.68929410
6MP0003693_abnormal_embryo_hatching3.67409647
7MP0000372_irregular_coat_pigmentation3.34866021
8MP0003195_calcinosis3.27225543
9MP0010352_gastrointestinal_tract_polyps3.02222678
10MP0010307_abnormal_tumor_latency2.94685614
11MP0001730_embryonic_growth_arrest2.86331059
12MP0008058_abnormal_DNA_repair2.62355390
13MP0003123_paternal_imprinting2.61767235
14MP0000350_abnormal_cell_proliferation2.60469763
15MP0005075_abnormal_melanosome_morpholog2.54258560
16MP0002396_abnormal_hematopoietic_system2.53921552
17MP0002837_dystrophic_cardiac_calcinosis2.47859027
18MP0008877_abnormal_DNA_methylation2.42073933
19MP0003121_genomic_imprinting2.34909013
20MP0008007_abnormal_cellular_replicative2.33065075
21MP0002102_abnormal_ear_morphology2.19741800
22MP0003890_abnormal_embryonic-extraembry2.18136255
23MP0005076_abnormal_cell_differentiation2.11345634
24MP0001697_abnormal_embryo_size2.08099967
25MP0006072_abnormal_retinal_apoptosis2.07941712
26MP0004808_abnormal_hematopoietic_stem2.05863180
27MP0002084_abnormal_developmental_patter2.05105978
28MP0005380_embryogenesis_phenotype2.04036262
29MP0001672_abnormal_embryogenesis/_devel2.04036262
30MP0004197_abnormal_fetal_growth/weight/1.93627901
31MP0002086_abnormal_extraembryonic_tissu1.91124407
32MP0005645_abnormal_hypothalamus_physiol1.89256511
33MP0000427_abnormal_hair_cycle1.87154272
34MP0002080_prenatal_lethality1.86807288
35MP0008932_abnormal_embryonic_tissue1.85691370
36MP0003806_abnormal_nucleotide_metabolis1.84939217
37MP0002938_white_spotting1.83963287
38MP0000569_abnormal_digit_pigmentation1.83317198
39MP0005408_hypopigmentation1.82435409
40MP0003984_embryonic_growth_retardation1.82297394
41MP0002088_abnormal_embryonic_growth/wei1.80345203
42MP0002085_abnormal_embryonic_tissue1.79488850
43MP0002163_abnormal_gland_morphology1.77069372
44MP0005379_endocrine/exocrine_gland_phen1.70828332
45MP0010234_abnormal_vibrissa_follicle1.68477680
46MP0005174_abnormal_tail_pigmentation1.66849260
47MP0000015_abnormal_ear_pigmentation1.65772057
48MP0006292_abnormal_olfactory_placode1.65713819
49MP0003705_abnormal_hypodermis_morpholog1.63925106
50MP0005253_abnormal_eye_physiology1.60281400
51MP0002638_abnormal_pupillary_reflex1.58961215
52MP0008995_early_reproductive_senescence1.55607609
53MP0003787_abnormal_imprinting1.47877651
54MP0008872_abnormal_physiological_respon1.45028657
55MP0001849_ear_inflammation1.43683751
56MP0000703_abnormal_thymus_morphology1.43446664
57MP0009697_abnormal_copulation1.42922305
58MP0000313_abnormal_cell_death1.41630510
59MP0005646_abnormal_pituitary_gland1.40934247
60MP0006035_abnormal_mitochondrial_morpho1.39896375
61MP0006036_abnormal_mitochondrial_physio1.39726662
62MP0005551_abnormal_eye_electrophysiolog1.39300501
63MP0004147_increased_porphyrin_level1.37007501
64MP0002019_abnormal_tumor_incidence1.32836682
65MP0004381_abnormal_hair_follicle1.32358940
66MP0002398_abnormal_bone_marrow1.31369503
67MP0002653_abnormal_ependyma_morphology1.30814259
68MP0000490_abnormal_crypts_of1.30443519
69MP0003172_abnormal_lysosome_physiology1.30070164
70MP0001293_anophthalmia1.29503917
71MP0003646_muscle_fatigue1.27892048
72MP0001545_abnormal_hematopoietic_system1.26549101
73MP0005397_hematopoietic_system_phenotyp1.26549101
74MP0002095_abnormal_skin_pigmentation1.26045376
75MP0005171_absent_coat_pigmentation1.25256453
76MP0000631_abnormal_neuroendocrine_gland1.22592018
77MP0005084_abnormal_gallbladder_morpholo1.21110478
78MP0002736_abnormal_nociception_after1.20934295
79MP0002722_abnormal_immune_system1.18168241
80MP0005389_reproductive_system_phenotype1.16179706
81MP0002876_abnormal_thyroid_physiology1.15873896
82MP0002090_abnormal_vision1.13909801
83MP0001485_abnormal_pinna_reflex1.13825762
84MP0002160_abnormal_reproductive_system1.13484642
85MP0003136_yellow_coat_color1.13319577
86MP0000689_abnormal_spleen_morphology1.12734419
87MP0005384_cellular_phenotype1.12370270
88MP0000647_abnormal_sebaceous_gland1.12116182
89MP0003763_abnormal_thymus_physiology1.10929458
90MP0005621_abnormal_cell_physiology1.10755237
91MP0002751_abnormal_autonomic_nervous1.08352276
92MP0003566_abnormal_cell_adhesion1.06261728
93MP0009046_muscle_twitch1.04886963
94MP0001968_abnormal_touch/_nociception1.02522549
95MP0003567_abnormal_fetal_cardiomyocyte1.02092243
96MP0003119_abnormal_digestive_system1.02021283
97MP0009672_abnormal_birth_weight1.01166489
98MP0009703_decreased_birth_body1.00090968
99MP0000358_abnormal_cell_content/0.99511458
100MP0003186_abnormal_redox_activity0.98936925
101MP0003300_gastrointestinal_ulcer0.97536993
102MP0001915_intracranial_hemorrhage0.97196411
103MP0001324_abnormal_eye_pigmentation0.96312726
104MP0008770_decreased_survivor_rate0.96184085
105MP0004233_abnormal_muscle_weight0.95980103
106MP0010678_abnormal_skin_adnexa0.95818179
107MP0004264_abnormal_extraembryonic_tissu0.95684703
108MP0004859_abnormal_synaptic_plasticity0.94564701
109MP0000516_abnormal_urinary_system0.93309957
110MP0005367_renal/urinary_system_phenotyp0.93309957
111MP0009278_abnormal_bone_marrow0.92628079
112MP0004142_abnormal_muscle_tone0.92229437
113MP0001764_abnormal_homeostasis0.91603741
114MP0002429_abnormal_blood_cell0.91486408
115MP0002234_abnormal_pharynx_morphology0.91092887
116MP0009840_abnormal_foam_cell0.90653933
117MP0001984_abnormal_olfaction0.90450717
118MP0003221_abnormal_cardiomyocyte_apopto0.90299978
119MP0005023_abnormal_wound_healing0.87945472
120MP0001919_abnormal_reproductive_system0.86716178
121MP0005220_abnormal_exocrine_pancreas0.86495764
122MP0003698_abnormal_male_reproductive0.86227498
123MP0003122_maternal_imprinting0.85936972
124MP0002693_abnormal_pancreas_physiology0.85805703
125MP0003943_abnormal_hepatobiliary_system0.84852175
126MP0005395_other_phenotype0.84551009
127MP0001119_abnormal_female_reproductive0.83019594
128MP0005332_abnormal_amino_acid0.83017275
129MP0001944_abnormal_pancreas_morphology0.82433893
130MP0003786_premature_aging0.82308626
131MP0001661_extended_life_span0.82174271
132MP0000428_abnormal_craniofacial_morphol0.81519976
133MP0000716_abnormal_immune_system0.81394829
134MP0003861_abnormal_nervous_system0.81040933
135MP0008875_abnormal_xenobiotic_pharmacok0.80930230
136MP0001529_abnormal_vocalization0.80252291
137MP0003303_peritoneal_inflammation0.80114062
138MP0001986_abnormal_taste_sensitivity0.79997268
139MP0001145_abnormal_male_reproductive0.78754021
140MP0002928_abnormal_bile_duct0.78308008
141MP0009745_abnormal_behavioral_response0.78245847
142MP0002210_abnormal_sex_determination0.76622936
143MP0004215_abnormal_myocardial_fiber0.76169050
144MP0002269_muscular_atrophy0.75301068
145MP0002089_abnormal_postnatal_growth/wei0.74178044
146MP0000733_abnormal_muscle_development0.73930257
147MP0009053_abnormal_anal_canal0.73780874
148MP0003632_abnormal_nervous_system0.72775329
149MP0002925_abnormal_cardiovascular_devel0.70441292
150MP0009780_abnormal_chondrocyte_physiolo0.69930217
151MP0003937_abnormal_limbs/digits/tail_de0.69921900
152MP0004185_abnormal_adipocyte_glucose0.68156718
153MP0003656_abnormal_erythrocyte_physiolo0.68140879
154MP0002092_abnormal_eye_morphology0.65968102
155MP0002166_altered_tumor_susceptibility0.65588884
156MP0005636_abnormal_mineral_homeostasis0.65430623
157MP0004885_abnormal_endolymph0.65149168
158MP0002909_abnormal_adrenal_gland0.64675293
159MP0009333_abnormal_splenocyte_physiolog0.64652753
160MP0000653_abnormal_sex_gland0.61958662
161MP0003091_abnormal_cell_migration0.61687733
162MP0005266_abnormal_metabolism0.60060865
163MP0000371_diluted_coat_color0.59083451
164MP0000477_abnormal_intestine_morphology0.58627981
165MP0000266_abnormal_heart_morphology0.58519540
166MP0001800_abnormal_humoral_immune0.58311264
167MP0001929_abnormal_gametogenesis0.54777769
168MP0002970_abnormal_white_adipose0.54621853
169MP0002083_premature_death0.54547025
170MP0000598_abnormal_liver_morphology0.53355150
171MP0005187_abnormal_penis_morphology0.52865765
172MP0003718_maternal_effect0.52156230

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.56850748
2Medulloblastoma (HP:0002885)4.14447331
3Abnormality of the labia minora (HP:0012880)3.87013886
4Agnosia (HP:0010524)3.61831935
5Neoplasm of the oral cavity (HP:0100649)3.56863551
6Volvulus (HP:0002580)3.54909192
7Abnormality of the astrocytes (HP:0100707)3.53263433
8Astrocytoma (HP:0009592)3.53263433
9Birth length less than 3rd percentile (HP:0003561)3.51051867
10Pancreatic cysts (HP:0001737)3.49879333
11Rhabdomyosarcoma (HP:0002859)3.49838467
12Neoplasm of striated muscle (HP:0009728)3.19056524
13Glioma (HP:0009733)3.09225418
14Colon cancer (HP:0003003)3.08117173
15Basal cell carcinoma (HP:0002671)3.07217692
16Hypothermia (HP:0002045)3.02745875
17Pancreatic fibrosis (HP:0100732)2.97109276
18Acute necrotizing encephalopathy (HP:0006965)2.96799982
19Progressive macrocephaly (HP:0004481)2.96022618
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95363447
21Short 4th metacarpal (HP:0010044)2.95363447
22Increased nuchal translucency (HP:0010880)2.85796760
23Acute encephalopathy (HP:0006846)2.81890451
24Increased CSF lactate (HP:0002490)2.79489276
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.76309215
26Annular pancreas (HP:0001734)2.75154719
27Proximal placement of thumb (HP:0009623)2.72886963
28Abnormality of the lower motor neuron (HP:0002366)2.72020369
29Selective tooth agenesis (HP:0001592)2.70198932
30Meckel diverticulum (HP:0002245)2.66753680
31True hermaphroditism (HP:0010459)2.62152239
32Hypoplasia of the fovea (HP:0007750)2.61098883
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.61098883
34Abnormality of the ileum (HP:0001549)2.59500975
35Deviation of the thumb (HP:0009603)2.56984679
36Mitochondrial inheritance (HP:0001427)2.55714786
37Abnormality of the preputium (HP:0100587)2.54501133
38Prominent nose (HP:0000448)2.51838874
39Abnormality of midbrain morphology (HP:0002418)2.51763519
40Molar tooth sign on MRI (HP:0002419)2.51763519
41Intestinal atresia (HP:0011100)2.49547539
42Abnormality of the renal cortex (HP:0011035)2.46066854
43Abnormal mitochondria in muscle tissue (HP:0008316)2.43210470
44Medial flaring of the eyebrow (HP:0010747)2.38349359
45High pitched voice (HP:0001620)2.37813663
46Methylmalonic acidemia (HP:0002912)2.36753095
47Amaurosis fugax (HP:0100576)2.35684684
48Abnormality of the anterior horn cell (HP:0006802)2.35464624
49Degeneration of anterior horn cells (HP:0002398)2.35464624
50Renal cortical cysts (HP:0000803)2.33869682
51Congenital stationary night blindness (HP:0007642)2.29255050
52Cutaneous melanoma (HP:0012056)2.29084521
53Thyroiditis (HP:0100646)2.28531634
54Impaired smooth pursuit (HP:0007772)2.28110391
55Large for gestational age (HP:0001520)2.26947179
56Nephronophthisis (HP:0000090)2.26092674
57Biliary tract neoplasm (HP:0100574)2.23882148
58Abnormality of the fovea (HP:0000493)2.23809474
59Cafe-au-lait spot (HP:0000957)2.22541399
60Increased hepatocellular lipid droplets (HP:0006565)2.21837883
61Abnormality of chromosome stability (HP:0003220)2.21100113
62Gastrointestinal carcinoma (HP:0002672)2.21064913
63Malignant gastrointestinal tract tumors (HP:0006749)2.21064913
64Abnormality of the duodenum (HP:0002246)2.20356177
65Myelodysplasia (HP:0002863)2.20317938
66Pendular nystagmus (HP:0012043)2.18257702
67Abnormal number of incisors (HP:0011064)2.18061201
68Cerebral edema (HP:0002181)2.17175788
69Sloping forehead (HP:0000340)2.16381546
70Neoplasm of the adrenal cortex (HP:0100641)2.15172106
71Breast hypoplasia (HP:0003187)2.14680598
72Hyperacusis (HP:0010780)2.14091331
73Supernumerary spleens (HP:0009799)2.14021004
74Hepatocellular necrosis (HP:0001404)2.13413540
75Abnormality of the fingertips (HP:0001211)2.13273886
76Oral leukoplakia (HP:0002745)2.13162469
77Progressive inability to walk (HP:0002505)2.12674992
78Obsessive-compulsive behavior (HP:0000722)2.11024457
79Hyperinsulinemic hypoglycemia (HP:0000825)2.10883252
80Abnormality of the salivary glands (HP:0010286)2.09015441
81Hepatic necrosis (HP:0002605)2.08860967
82Broad palm (HP:0001169)2.08440556
83Abnormality of the 4th metacarpal (HP:0010012)2.08014462
84Cerebral hypomyelination (HP:0006808)2.07279344
85Spastic diplegia (HP:0001264)2.07010706
86Abnormality of ocular smooth pursuit (HP:0000617)2.06078549
87Vertebral arch anomaly (HP:0008438)2.05205280
88Thrombocytosis (HP:0001894)2.03931349
89Clubbing of toes (HP:0100760)2.03695488
90Chromsome breakage (HP:0040012)2.02812964
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.02774601
92Lipid accumulation in hepatocytes (HP:0006561)2.01848840
93Abnormality of the renal medulla (HP:0100957)2.01455002
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.00867811
95Albinism (HP:0001022)2.00136565
96Duplicated collecting system (HP:0000081)1.99853917
97Pointed chin (HP:0000307)1.99728103
98Urethral obstruction (HP:0000796)1.98569565
99Abnormal rod and cone electroretinograms (HP:0008323)1.98491304
100Gaze-evoked nystagmus (HP:0000640)1.98029791
101Heterotopia (HP:0002282)1.97704481
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.97541153
103Abnormality of the pons (HP:0007361)1.97022020
104Patellar aplasia (HP:0006443)1.96391224
105Abnormality of the renal collecting system (HP:0004742)1.95625679
106Breast carcinoma (HP:0003002)1.95324756
107Short tibia (HP:0005736)1.95206981
108Upper motor neuron abnormality (HP:0002127)1.95109045
109Freckling (HP:0001480)1.94435902
110Spinal muscular atrophy (HP:0007269)1.94251378
111Long eyelashes (HP:0000527)1.92965078
112Adrenal hypoplasia (HP:0000835)1.92738337
113Methylmalonic aciduria (HP:0012120)1.92460289
114Truncal obesity (HP:0001956)1.91921144
115Increased serum lactate (HP:0002151)1.91890091
116Abnormality of the motor neurons (HP:0002450)1.90246137
117Abnormal neuron morphology (HP:0012757)1.90246137
118Low anterior hairline (HP:0000294)1.89015086
119Shawl scrotum (HP:0000049)1.88895121
120Sandal gap (HP:0001852)1.88807685
121Absent thumb (HP:0009777)1.87017437
122Acute myeloid leukemia (HP:0004808)1.86796959
123Cutis marmorata (HP:0000965)1.86513799
124Papilledema (HP:0001085)1.85608406
125Angiofibromas (HP:0010615)1.85606328
126Adenoma sebaceum (HP:0009720)1.85606328
127IgM deficiency (HP:0002850)1.85490379
128Hypoplasia of the pons (HP:0012110)1.84830487
129Skin tags (HP:0010609)1.84402499
130Tongue fasciculations (HP:0001308)1.83805900
131Pancreatic islet-cell hyperplasia (HP:0004510)1.83598880
132Abnormality of vitamin B metabolism (HP:0004340)1.83290948
133Hypoglycemic coma (HP:0001325)1.83039345
134Hypoglycemic seizures (HP:0002173)1.83025846
135Ectopic kidney (HP:0000086)1.82870145
136Global brain atrophy (HP:0002283)1.81994903
137Neoplasm of the pancreas (HP:0002894)1.81268902
138Attention deficit hyperactivity disorder (HP:0007018)1.81211125
139Trigonocephaly (HP:0000243)1.81189950
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.80881179
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80657820
142Ketoacidosis (HP:0001993)1.80001292
143Abolished electroretinogram (ERG) (HP:0000550)1.79354706
144Lymphoma (HP:0002665)1.79331044
1453-Methylglutaconic aciduria (HP:0003535)1.77727159
146Abnormal biliary tract physiology (HP:0012439)1.77453184
147Bile duct proliferation (HP:0001408)1.77453184
148Sparse lateral eyebrow (HP:0005338)1.76070519
149Impulsivity (HP:0100710)1.75581971
150Furrowed tongue (HP:0000221)1.75359222
151Small hand (HP:0200055)1.75122717
152Fibrous tissue neoplasm (HP:0012316)1.74778254
153Limb hypertonia (HP:0002509)1.74775685
154Prominent metopic ridge (HP:0005487)1.73885166
155Aplasia/Hypoplasia of the patella (HP:0006498)1.73735288
156Dysmetric saccades (HP:0000641)1.73659960
157Duodenal stenosis (HP:0100867)1.73475316
158Small intestinal stenosis (HP:0012848)1.73475316
159Hyperalaninemia (HP:0003348)1.73331631
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73331631
161Abnormality of alanine metabolism (HP:0010916)1.73331631
162Neoplasm of the adrenal gland (HP:0100631)1.73327319
163Aqueductal stenosis (HP:0002410)1.73317210
164Ovarian neoplasm (HP:0100615)1.72477662
165Intestinal polyp (HP:0005266)1.72401117
166Attenuation of retinal blood vessels (HP:0007843)1.71627457
167Supernumerary bones of the axial skeleton (HP:0009144)1.71235228
168B lymphocytopenia (HP:0010976)1.70799978
169Abnormality of B cell number (HP:0010975)1.70799978
170Abnormality of chromosome segregation (HP:0002916)1.70415282
171Atresia of the external auditory canal (HP:0000413)1.70392337
172Aplasia/hypoplasia of the uterus (HP:0008684)1.69722377
173Nephrogenic diabetes insipidus (HP:0009806)1.69503818
174Hyperglycemia (HP:0003074)1.69464623
175T lymphocytopenia (HP:0005403)1.69454239
176Overlapping toe (HP:0001845)1.68608249
177Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68409538
178Congenital primary aphakia (HP:0007707)1.68334303
179Hypomagnesemia (HP:0002917)1.68138463
180Cystic liver disease (HP:0006706)1.67765530
181Fibroma (HP:0010614)1.67328814
182Lactic acidosis (HP:0003128)1.67158598
183Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67140411
184Type II lissencephaly (HP:0007260)1.67123743
185Papillary thyroid carcinoma (HP:0002895)1.66298063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.53511712
2CDC74.36125276
3CDK123.90266120
4MST43.23058346
5TRIM283.16957966
6NEK13.05653896
7TTK2.77568296
8EEF2K2.75258909
9NEK22.68137517
10NUAK12.65581096
11WEE12.54613901
12PKN22.35127856
13EIF2AK12.29617130
14TSSK62.16611043
15ERBB32.09900655
16STK392.08524042
17WNK32.06273182
18ZAK2.05826127
19BUB12.03998070
20MAP4K22.01176135
21TESK22.00910050
22PLK21.99856457
23CDK41.95624397
24ALK1.93117011
25STK101.89374048
26BRD41.83320543
27SCYL21.81728968
28BMPR1B1.79726600
29ATR1.75113342
30OXSR11.73312978
31MAP3K101.68200516
32TNIK1.66123765
33TGFBR11.62375319
34MAP3K131.60948448
35MAP3K81.55513962
36MAP3K91.54547669
37GRK11.53797532
38RPS6KB21.47860400
39PLK11.45467583
40PASK1.41603074
41BCR1.41596629
42CDK61.41594461
43CHEK11.40200593
44VRK11.38993482
45PLK41.29595281
46CHEK21.29229082
47PLK31.27134442
48CDK71.22453805
49SIK21.21672286
50MAP4K11.20379125
51PAK31.17216739
52STK161.17045045
53ACVR1B1.14349398
54FGFR21.13539856
55PAK41.13418654
56AURKB1.13084056
57ADRBK21.12065749
58PDK21.10965252
59SRPK11.10622518
60CSNK1G11.09273003
61CDK21.09219860
62VRK21.08815946
63MKNK11.08257639
64ATM1.06146485
65FER1.04053791
66MAP3K120.99156461
67TAOK10.98707067
68KSR20.97355769
69EIF2AK20.96526340
70PNCK0.94820137
71WNK40.93376776
72CSNK1G30.92443877
73CASK0.92274025
74MAP3K40.91962699
75FLT30.91760457
76PBK0.88636795
77PHKG20.87493149
78PHKG10.87493149
79LRRK20.87345717
80CSNK1G20.87222487
81STK38L0.85424253
82KSR10.83125633
83TYRO30.80649589
84TAOK30.80622511
85TRIB30.79397503
86EIF2AK30.79194868
87STK40.79027276
88CDK10.78340790
89TAF10.78110583
90CLK10.77576152
91PRKCI0.76998289
92FGFR10.76607411
93GRK60.76431349
94INSRR0.75475509
95BRSK20.74505390
96MTOR0.72600013
97PRKCE0.72251915
98AKT30.70949072
99BRSK10.70599838
100FGFR30.69979781
101CSNK1E0.69255775
102MAPK130.68333178
103RIPK10.67004630
104MAP2K70.63802869
105NLK0.63343681
106CCNB10.61428779
107CSNK1D0.60117964
108RET0.58854252
109BMPR20.58683227
110DYRK30.57925732
111PRKDC0.57660429
112LATS10.56939326
113PINK10.56644557
114DAPK10.56559601
115NME10.56060758
116MELK0.55658621
117STK30.54874341
118SIK30.54501934
119MAPK100.49061557
120MAPK140.49026550
121CSNK2A20.48468281
122STK240.47081063
123CSF1R0.46913253
124TEC0.46598601
125TLK10.45338236
126PRKCG0.44013874
127AURKA0.43738616
128MKNK20.42400904
129FES0.41844961
130RAF10.41246917
131SGK30.40470681
132RPS6KA40.39714591
133CDK150.39300588
134GSK3B0.39253397
135CDK180.39104053
136CSNK1A1L0.37218376
137BTK0.36940457
138CDK11A0.35955030
139CDK30.35327185
140TXK0.34582639
141IRAK10.34552584
142ZAP700.34452042
143MAPK110.33982216
144EPHA20.33627882
145MAPK10.33225782
146MUSK0.32712020
147CSNK2A10.32351717
148CDK140.32121922
149CDK90.30672837
150PIM10.30405117
151CSNK1A10.30086435
152MARK30.29916627
153ERN10.29371483
154BMX0.29224438
155DYRK20.28643211
156PTK60.28578567
157AKT20.28026009
158MAPKAPK30.26895283
159RPS6KA50.24752701
160ADRBK10.24560813
161TIE10.23989356
162PRKCQ0.23811060

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39864665
2Mismatch repair_Homo sapiens_hsa034303.78720269
3Proteasome_Homo sapiens_hsa030503.61631678
4Protein export_Homo sapiens_hsa030603.51621588
5RNA transport_Homo sapiens_hsa030133.11684582
6One carbon pool by folate_Homo sapiens_hsa006703.09709037
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07699330
8Spliceosome_Homo sapiens_hsa030402.97818942
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91220542
10Cell cycle_Homo sapiens_hsa041102.82413368
11Base excision repair_Homo sapiens_hsa034102.59557854
12Nucleotide excision repair_Homo sapiens_hsa034202.30208114
13mRNA surveillance pathway_Homo sapiens_hsa030152.26375223
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17359959
15Non-homologous end-joining_Homo sapiens_hsa034502.16875390
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10954016
17Propanoate metabolism_Homo sapiens_hsa006402.01792953
18Oxidative phosphorylation_Homo sapiens_hsa001902.00488336
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98732531
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.98227577
21Nitrogen metabolism_Homo sapiens_hsa009101.93644508
22Homologous recombination_Homo sapiens_hsa034401.88590618
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82094773
24Oocyte meiosis_Homo sapiens_hsa041141.81007940
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68881076
26Parkinsons disease_Homo sapiens_hsa050121.66254329
27RNA degradation_Homo sapiens_hsa030181.64864643
28Butanoate metabolism_Homo sapiens_hsa006501.60650261
29Fanconi anemia pathway_Homo sapiens_hsa034601.57509366
30Sulfur metabolism_Homo sapiens_hsa009201.51459610
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50287900
32Fatty acid elongation_Homo sapiens_hsa000621.46958815
33mTOR signaling pathway_Homo sapiens_hsa041501.46516204
34Biosynthesis of amino acids_Homo sapiens_hsa012301.38861102
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37618491
36Viral carcinogenesis_Homo sapiens_hsa052031.30215105
37Phototransduction_Homo sapiens_hsa047441.28842800
38Caffeine metabolism_Homo sapiens_hsa002321.28414854
39Systemic lupus erythematosus_Homo sapiens_hsa053221.23177617
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19914968
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16027054
42p53 signaling pathway_Homo sapiens_hsa041151.15826623
43Tryptophan metabolism_Homo sapiens_hsa003801.15617072
44Selenocompound metabolism_Homo sapiens_hsa004501.14349382
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13311051
46Colorectal cancer_Homo sapiens_hsa052101.13062697
47RNA polymerase_Homo sapiens_hsa030201.12641772
48Huntingtons disease_Homo sapiens_hsa050161.12276671
49Pyrimidine metabolism_Homo sapiens_hsa002401.11969710
50Steroid biosynthesis_Homo sapiens_hsa001001.10892189
51Non-small cell lung cancer_Homo sapiens_hsa052231.10581798
52Antigen processing and presentation_Homo sapiens_hsa046121.04956169
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04323291
54Regulation of autophagy_Homo sapiens_hsa041401.04286215
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.04266260
56Epstein-Barr virus infection_Homo sapiens_hsa051691.01458091
57Collecting duct acid secretion_Homo sapiens_hsa049661.00892477
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00647422
59Chronic myeloid leukemia_Homo sapiens_hsa052200.98958004
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96127785
61MicroRNAs in cancer_Homo sapiens_hsa052060.95107648
62HTLV-I infection_Homo sapiens_hsa051660.95060218
63Peroxisome_Homo sapiens_hsa041460.93578096
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93219338
65Thyroid cancer_Homo sapiens_hsa052160.92357448
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90980919
67Alzheimers disease_Homo sapiens_hsa050100.88742256
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.88615676
69Lysine degradation_Homo sapiens_hsa003100.87026266
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84345063
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.83040850
72Linoleic acid metabolism_Homo sapiens_hsa005910.80233792
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.79466445
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79344544
75Herpes simplex infection_Homo sapiens_hsa051680.79275600
76Ether lipid metabolism_Homo sapiens_hsa005650.79190238
77Basal transcription factors_Homo sapiens_hsa030220.76442491
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76299295
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75763365
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75480331
81Primary immunodeficiency_Homo sapiens_hsa053400.72542565
82Alcoholism_Homo sapiens_hsa050340.71861688
83Circadian rhythm_Homo sapiens_hsa047100.71495384
84Vitamin B6 metabolism_Homo sapiens_hsa007500.70933871
85Pancreatic cancer_Homo sapiens_hsa052120.70101394
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69326199
87Small cell lung cancer_Homo sapiens_hsa052220.67863245
88Metabolic pathways_Homo sapiens_hsa011000.67555001
89Folate biosynthesis_Homo sapiens_hsa007900.67459840
90B cell receptor signaling pathway_Homo sapiens_hsa046620.66916996
91Pyruvate metabolism_Homo sapiens_hsa006200.66122317
92Glioma_Homo sapiens_hsa052140.65914447
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65097554
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63266048
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62812422
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62386103
97Long-term potentiation_Homo sapiens_hsa047200.58955473
98Hepatitis B_Homo sapiens_hsa051610.58560490
99Notch signaling pathway_Homo sapiens_hsa043300.58209849
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58152944
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55816215
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55703777
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55192405
104Shigellosis_Homo sapiens_hsa051310.54797599
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54578538
106HIF-1 signaling pathway_Homo sapiens_hsa040660.54467356
107Fatty acid metabolism_Homo sapiens_hsa012120.54448980
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53266273
109VEGF signaling pathway_Homo sapiens_hsa043700.52014504
110Glutathione metabolism_Homo sapiens_hsa004800.51984131
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51966055
112Renal cell carcinoma_Homo sapiens_hsa052110.51500490
113T cell receptor signaling pathway_Homo sapiens_hsa046600.50045007
114Hippo signaling pathway_Homo sapiens_hsa043900.49744115
115Pentose phosphate pathway_Homo sapiens_hsa000300.48844744
116Endometrial cancer_Homo sapiens_hsa052130.47502054
117Proteoglycans in cancer_Homo sapiens_hsa052050.46078503
118Apoptosis_Homo sapiens_hsa042100.45403511
119Inositol phosphate metabolism_Homo sapiens_hsa005620.44602938
120Purine metabolism_Homo sapiens_hsa002300.43478762
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43146418
122Olfactory transduction_Homo sapiens_hsa047400.42784231
123Adherens junction_Homo sapiens_hsa045200.42089932
124Carbon metabolism_Homo sapiens_hsa012000.41747423
125Nicotine addiction_Homo sapiens_hsa050330.41542410
126Arginine biosynthesis_Homo sapiens_hsa002200.41184548
127N-Glycan biosynthesis_Homo sapiens_hsa005100.41113505
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41030535
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40360476
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39712796
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39177906
132beta-Alanine metabolism_Homo sapiens_hsa004100.38001069
133Type II diabetes mellitus_Homo sapiens_hsa049300.37379631
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.36820489
135Dorso-ventral axis formation_Homo sapiens_hsa043200.36799902
136Pathways in cancer_Homo sapiens_hsa052000.36235929
137TGF-beta signaling pathway_Homo sapiens_hsa043500.34540832
138Acute myeloid leukemia_Homo sapiens_hsa052210.33886507
139Insulin secretion_Homo sapiens_hsa049110.33840289
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33221402
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33169899
142ErbB signaling pathway_Homo sapiens_hsa040120.32752798
143Ribosome_Homo sapiens_hsa030100.32114565
144Insulin signaling pathway_Homo sapiens_hsa049100.31125929
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30350846
146Estrogen signaling pathway_Homo sapiens_hsa049150.29631833
147Taste transduction_Homo sapiens_hsa047420.29223554
148Prostate cancer_Homo sapiens_hsa052150.28975447
149MAPK signaling pathway_Homo sapiens_hsa040100.28669854
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28289179
151Fatty acid degradation_Homo sapiens_hsa000710.28024094
152FoxO signaling pathway_Homo sapiens_hsa040680.27983894
153Serotonergic synapse_Homo sapiens_hsa047260.27912163
154Bladder cancer_Homo sapiens_hsa052190.27355992
155Viral myocarditis_Homo sapiens_hsa054160.26735515
156Rap1 signaling pathway_Homo sapiens_hsa040150.26563601
157Platelet activation_Homo sapiens_hsa046110.26196814
158Chemical carcinogenesis_Homo sapiens_hsa052040.24747391
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.24600121
160Retinol metabolism_Homo sapiens_hsa008300.19189872
161ABC transporters_Homo sapiens_hsa020100.18698402
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18455473
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17136735
164Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15473675
165Legionellosis_Homo sapiens_hsa051340.14407640
166Sphingolipid metabolism_Homo sapiens_hsa006000.14260540

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