RBBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)6.69240989
2nuclear pore complex assembly (GO:0051292)5.42163512
3centriole replication (GO:0007099)4.96847192
4nuclear pore organization (GO:0006999)4.74352286
5regulation of centriole replication (GO:0046599)4.53252293
6histone H3-K4 trimethylation (GO:0080182)4.46103835
7regulation of DNA endoreduplication (GO:0032875)4.41905063
8regulation of RNA export from nucleus (GO:0046831)4.35903894
9cytoplasmic mRNA processing body assembly (GO:0033962)4.34029513
10pre-miRNA processing (GO:0031054)4.05672159
11sister chromatid cohesion (GO:0007062)4.02048288
12pore complex assembly (GO:0046931)4.00449570
13histone H3-K9 methylation (GO:0051567)3.99186762
14replication fork processing (GO:0031297)3.90321675
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.88173480
16regulation of translation, ncRNA-mediated (GO:0045974)3.88173480
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.88173480
18peptidyl-lysine trimethylation (GO:0018023)3.86999495
19regulation of centrosome duplication (GO:0010824)3.78979451
20positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.78345534
21regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.78345534
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.77681997
23establishment of protein localization to Golgi (GO:0072600)3.76858720
24histone H3-K4 methylation (GO:0051568)3.67732401
25positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.64508917
26regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.64508917
27histone H3-K9 modification (GO:0061647)3.64039588
28regulation of nucleobase-containing compound transport (GO:0032239)3.61308360
29maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.60462910
30meiotic chromosome segregation (GO:0045132)3.58100306
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.55849096
32protein targeting to Golgi (GO:0000042)3.48977650
33centriole assembly (GO:0098534)3.47667004
34regulation of centrosome cycle (GO:0046605)3.42304920
35mitotic sister chromatid segregation (GO:0000070)3.41447189
36DNA unwinding involved in DNA replication (GO:0006268)3.41284671
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.38912131
38otic vesicle formation (GO:0030916)3.34654782
39negative regulation of histone methylation (GO:0031061)3.32532390
40histone lysine methylation (GO:0034968)3.30946406
41monoubiquitinated protein deubiquitination (GO:0035520)3.29196597
42mitotic G2/M transition checkpoint (GO:0044818)3.25446558
43kinetochore organization (GO:0051383)3.22440525
44interkinetic nuclear migration (GO:0022027)3.22208196
45mRNA splice site selection (GO:0006376)3.17217355
46centrosome organization (GO:0051297)3.13246156
47regulation of histone H3-K9 methylation (GO:0051570)3.11459825
48protein localization to kinetochore (GO:0034501)3.10561570
49regulation of mRNA splicing, via spliceosome (GO:0048024)3.07912419
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.07847524
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07847524
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07847524
53glucocorticoid receptor signaling pathway (GO:0042921)3.06236200
54DNA packaging (GO:0006323)3.05946940
55positive regulation of mRNA 3-end processing (GO:0031442)3.05445572
56microtubule organizing center organization (GO:0031023)3.04607656
57regulation of mRNA 3-end processing (GO:0031440)3.04472217
58histone H3-K36 demethylation (GO:0070544)3.03578912
59negative regulation of DNA repair (GO:0045738)3.03366806
60chromosome condensation (GO:0030261)3.03123904
61negative regulation of RNA splicing (GO:0033119)3.02617995
62chromatin remodeling at centromere (GO:0031055)2.99511181
63DNA replication checkpoint (GO:0000076)2.98935675
64histone H3-K9 demethylation (GO:0033169)2.96095643
65peptidyl-lysine methylation (GO:0018022)2.93353574
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93347098
67mRNA stabilization (GO:0048255)2.92324186
68RNA stabilization (GO:0043489)2.92324186
69negative regulation of DNA recombination (GO:0045910)2.92116284
70NLS-bearing protein import into nucleus (GO:0006607)2.91431717
71poly(A)+ mRNA export from nucleus (GO:0016973)2.89537921
72positive regulation of mRNA catabolic process (GO:0061014)2.89446512
73microtubule depolymerization (GO:0007019)2.88400474
74microtubule anchoring (GO:0034453)2.88015022
75gene silencing by RNA (GO:0031047)2.84013289
76DNA topological change (GO:0006265)2.83963526
77cerebral cortex radially oriented cell migration (GO:0021799)2.83780538
78histone exchange (GO:0043486)2.82284009
79double-strand break repair via homologous recombination (GO:0000724)2.80805376
80microtubule polymerization or depolymerization (GO:0031109)2.80180978
81regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.79138284
82recombinational repair (GO:0000725)2.78535293
83histone methylation (GO:0016571)2.78213373
84DNA replication-independent nucleosome assembly (GO:0006336)2.77830425
85DNA replication-independent nucleosome organization (GO:0034724)2.77830425
86mitotic chromosome condensation (GO:0007076)2.77665793
87corticosteroid receptor signaling pathway (GO:0031958)2.77020594
88alternative mRNA splicing, via spliceosome (GO:0000380)2.76212722
89DNA double-strand break processing (GO:0000729)2.76196084
90termination of RNA polymerase II transcription (GO:0006369)2.74344446
91histone lysine demethylation (GO:0070076)2.73607670
92metaphase plate congression (GO:0051310)2.73252909
93positive regulation of mRNA processing (GO:0050685)2.72667437
94CENP-A containing nucleosome assembly (GO:0034080)2.71594776
95regulation of histone methylation (GO:0031060)2.71053659
96N-terminal protein amino acid acetylation (GO:0006474)2.70759950
97synaptonemal complex assembly (GO:0007130)2.70532336
98nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.69498667
99protein K11-linked deubiquitination (GO:0035871)2.69427400
100heterochromatin organization (GO:0070828)2.69013523
101regulation of mRNA catabolic process (GO:0061013)2.67478783
102regulation of sister chromatid cohesion (GO:0007063)2.67409576
103single strand break repair (GO:0000012)2.66049736
104mitotic G2 DNA damage checkpoint (GO:0007095)2.65424631
105histone H4-K16 acetylation (GO:0043984)2.65386986
106DNA conformation change (GO:0071103)2.65226297
107histone demethylation (GO:0016577)2.64743690
108positive regulation of chromosome segregation (GO:0051984)2.64692997
109kinetochore assembly (GO:0051382)2.64656246
110heart valve formation (GO:0003188)2.64584024
111DNA alkylation (GO:0006305)2.64524138
112DNA methylation (GO:0006306)2.64524138
113regulation of DNA-templated transcription, initiation (GO:2000142)2.64379938
114sister chromatid segregation (GO:0000819)2.62422754
115regulation of spindle organization (GO:0090224)2.61309906
116negative regulation of smooth muscle cell differentiation (GO:0051151)2.60928117
117positive regulation of histone H3-K4 methylation (GO:0051571)2.59670140
118rRNA catabolic process (GO:0016075)2.59576356
119negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.59455321
120centrosome duplication (GO:0051298)2.57385319
121resolution of meiotic recombination intermediates (GO:0000712)2.57172685
122positive regulation of histone methylation (GO:0031062)2.56829545
123regulation of mRNA stability (GO:0043488)2.56034073
124retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55904354
125histone H4 acetylation (GO:0043967)2.54908875
126histone deubiquitination (GO:0016578)2.54826012
127regulation of RNA splicing (GO:0043484)2.54603183
128regulation of meiosis I (GO:0060631)2.52896522
129gene silencing (GO:0016458)2.52643399
130regulation of telomere maintenance (GO:0032204)2.52567249
131positive regulation of DNA-templated transcription, initiation (GO:2000144)2.51019571
132mitotic metaphase plate congression (GO:0007080)2.50024302
133protein-DNA complex disassembly (GO:0032986)2.48733762
134nucleosome disassembly (GO:0006337)2.48733762
135synaptonemal complex organization (GO:0070193)2.47140996
136histone H4-K12 acetylation (GO:0043983)2.46940921
137negative regulation of histone modification (GO:0031057)2.43931090
138DNA duplex unwinding (GO:0032508)2.39055758
139histone mRNA catabolic process (GO:0071044)2.38998108
140negative regulation of mRNA metabolic process (GO:1903312)2.38905689
141DNA geometric change (GO:0032392)2.38587599
142protein localization to chromosome, centromeric region (GO:0071459)2.38419311
143regulation of mRNA processing (GO:0050684)2.38235329
144positive regulation of mRNA metabolic process (GO:1903313)2.37637709
145histone acetylation (GO:0016573)2.37581905
146negative regulation of mRNA processing (GO:0050686)2.36992087
147regulation of histone H3-K4 methylation (GO:0051569)2.35972124
148negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35078063
149mitotic nuclear envelope disassembly (GO:0007077)2.34402173
150histone H2A monoubiquitination (GO:0035518)2.32454732
151stress granule assembly (GO:0034063)2.31616884
152positive regulation by host of viral transcription (GO:0043923)2.31228694
153piRNA metabolic process (GO:0034587)2.31213339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28938945
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.20823405
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10510005
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.75725324
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07567014
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.90416288
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86188752
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68814045
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58819672
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58770958
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44528471
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23619214
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23308631
14FUS_26573619_Chip-Seq_HEK293_Human2.16541490
15VDR_22108803_ChIP-Seq_LS180_Human2.12087463
16ZNF274_21170338_ChIP-Seq_K562_Hela2.02425551
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99733064
18EWS_26573619_Chip-Seq_HEK293_Human1.84049538
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79626592
20FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.76664484
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73064050
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72814964
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67978872
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.67025022
25ELK1_19687146_ChIP-ChIP_HELA_Human1.67013958
26TP53_16413492_ChIP-PET_HCT116_Human1.65776743
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.64751833
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63770115
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63323608
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.59706235
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59291832
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55117905
33* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54142841
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53578778
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.48910876
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45745561
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45745561
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43645732
39TAF15_26573619_Chip-Seq_HEK293_Human1.41067094
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40387892
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35259615
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33714057
43* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32739031
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.31660850
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31416793
46ER_23166858_ChIP-Seq_MCF-7_Human1.31105875
47MYC_22102868_ChIP-Seq_BL_Human1.29804564
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29443124
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29392546
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28785152
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28042594
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27603053
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25960866
54VDR_23849224_ChIP-Seq_CD4+_Human1.25397699
55* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23318684
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22526381
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20341508
58IGF1R_20145208_ChIP-Seq_DFB_Human1.19236866
59* CBP_20019798_ChIP-Seq_JUKART_Human1.18040093
60* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18040093
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.16995764
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16976996
63STAT3_23295773_ChIP-Seq_U87_Human1.16104718
64* ISL1_27105846_Chip-Seq_CPCs_Mouse1.14286620
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13190294
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13170736
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13170736
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13170736
69* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12458732
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11932811
71TCF7_22412390_ChIP-Seq_EML_Mouse1.11007658
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10475572
73CIITA_25753668_ChIP-Seq_RAJI_Human1.10002998
74MYC_18940864_ChIP-ChIP_HL60_Human1.09974643
75* TCF4_23295773_ChIP-Seq_U87_Human1.09702049
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.09151706
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08931720
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.08375308
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.05949655
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04959660
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04827351
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04703782
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04378225
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04144063
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04073944
86* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03684344
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03456150
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03422011
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.02944712
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02773355
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.02611638
92AR_21572438_ChIP-Seq_LNCaP_Human1.02027382
93SOX9_26525672_Chip-Seq_HEART_Mouse1.01849898
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01206921
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.01009669
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00844702
97RNF2_27304074_Chip-Seq_NSC_Mouse1.00449506
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00160783
99* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00160432
100EZH2_22144423_ChIP-Seq_EOC_Human1.00064253
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00023810
102AR_21909140_ChIP-Seq_LNCAP_Human0.99723359
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99412831
104RUNX_20019798_ChIP-Seq_JUKART_Human0.99325837
105SMAD4_21799915_ChIP-Seq_A2780_Human0.99070551
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98694329
107AHR_22903824_ChIP-Seq_MCF-7_Human0.98609170
108IRF1_19129219_ChIP-ChIP_H3396_Human0.98249163
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.98175066
110BRD4_25478319_ChIP-Seq_HGPS_Human0.98080033
111TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97877137
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.97437618
113TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97074313
114* FOXP3_21729870_ChIP-Seq_TREG_Human0.97035739
115TBL1_22424771_ChIP-Seq_293T_Human0.95866644
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.95811499
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95772131
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.95672635
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95429883
120GABP_17652178_ChIP-ChIP_JURKAT_Human0.95277039
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94817993
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94621961
123* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94458969
124P300_19829295_ChIP-Seq_ESCs_Human0.93786066
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.93489099
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93301992
127MYB_26560356_Chip-Seq_TH1_Human0.92294723
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92157896
129TTF2_22483619_ChIP-Seq_HELA_Human0.92128215
130* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91846274
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91550514
132RUNX2_22187159_ChIP-Seq_PCA_Human0.91316653
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91192134
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88825009
135GATA1_22025678_ChIP-Seq_K562_Human0.88811967
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.88702351
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88066792
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86657913
139SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86131412
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85783028
141GBX2_23144817_ChIP-Seq_PC3_Human0.84675683
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84601018
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83667781
144OCT4_18555785_Chip-Seq_ESCs_Mouse0.83639188
145P53_22387025_ChIP-Seq_ESCs_Mouse0.83375178
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82515160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.15367930
2MP0008877_abnormal_DNA_methylation3.83326777
3MP0003787_abnormal_imprinting3.16304284
4MP0000569_abnormal_digit_pigmentation2.99241718
5MP0003121_genomic_imprinting2.48547322
6MP0010094_abnormal_chromosome_stability2.37700190
7MP0002396_abnormal_hematopoietic_system2.19047334
8MP0003111_abnormal_nucleus_morphology2.13973854
9MP0002009_preneoplasia2.06524664
10MP0006292_abnormal_olfactory_placode2.03919200
11MP0003890_abnormal_embryonic-extraembry2.03382625
12MP0005409_darkened_coat_color1.91955890
13MP0003077_abnormal_cell_cycle1.84408304
14MP0005076_abnormal_cell_differentiation1.82267654
15MP0008058_abnormal_DNA_repair1.76728938
16MP0000383_abnormal_hair_follicle1.76552149
17MP0004808_abnormal_hematopoietic_stem1.73090160
18MP0000566_synostosis1.66365844
19MP0003937_abnormal_limbs/digits/tail_de1.61692172
20MP0009703_decreased_birth_body1.53262358
21MP0008007_abnormal_cellular_replicative1.52535250
22MP0000778_abnormal_nervous_system1.52454264
23MP0002084_abnormal_developmental_patter1.51358473
24MP0003935_abnormal_craniofacial_develop1.50084297
25MP0003123_paternal_imprinting1.48161635
26MP0003122_maternal_imprinting1.47405625
27* MP0003984_embryonic_growth_retardation1.42987677
28MP0001293_anophthalmia1.42027373
29MP0000428_abnormal_craniofacial_morphol1.41656488
30MP0003385_abnormal_body_wall1.39646332
31* MP0005380_embryogenesis_phenotype1.39506060
32* MP0001672_abnormal_embryogenesis/_devel1.39506060
33MP0010307_abnormal_tumor_latency1.39084475
34MP0004197_abnormal_fetal_growth/weight/1.39007524
35* MP0002088_abnormal_embryonic_growth/wei1.38946257
36MP0000432_abnormal_head_morphology1.35701112
37MP0010352_gastrointestinal_tract_polyps1.33349191
38MP0002085_abnormal_embryonic_tissue1.32601151
39MP0002210_abnormal_sex_determination1.31722312
40MP0000631_abnormal_neuroendocrine_gland1.31223997
41MP0010678_abnormal_skin_adnexa1.31196910
42MP0009053_abnormal_anal_canal1.31095775
43MP0002166_altered_tumor_susceptibility1.30904931
44MP0000350_abnormal_cell_proliferation1.29148352
45MP0005394_taste/olfaction_phenotype1.26465112
46MP0005499_abnormal_olfactory_system1.26465112
47MP0003755_abnormal_palate_morphology1.26052582
48MP0001730_embryonic_growth_arrest1.23853462
49MP0003693_abnormal_embryo_hatching1.23813104
50MP0002938_white_spotting1.21986951
51MP0001929_abnormal_gametogenesis1.20740799
52MP0002086_abnormal_extraembryonic_tissu1.20002205
53MP0004885_abnormal_endolymph1.18744243
54MP0009672_abnormal_birth_weight1.15977451
55MP0008995_early_reproductive_senescence1.15020182
56MP0004742_abnormal_vestibular_system1.14870680
57MP0002163_abnormal_gland_morphology1.14801779
58MP0002138_abnormal_hepatobiliary_system1.12562212
59MP0009250_abnormal_appendicular_skeleto1.11611646
60MP0000703_abnormal_thymus_morphology1.10918290
61MP0002925_abnormal_cardiovascular_devel1.10537239
62* MP0001697_abnormal_embryo_size1.08922046
63MP0001485_abnormal_pinna_reflex1.06505413
64MP0004957_abnormal_blastocyst_morpholog1.06452872
65MP0005187_abnormal_penis_morphology1.05200927
66MP0001286_abnormal_eye_development1.04695926
67MP0003115_abnormal_respiratory_system1.04650889
68MP0001145_abnormal_male_reproductive1.04429775
69MP0003786_premature_aging1.04406334
70MP0000733_abnormal_muscle_development1.02878465
71MP0003941_abnormal_skin_development1.01955942
72MP0000653_abnormal_sex_gland0.98506002
73MP0009379_abnormal_foot_pigmentation0.98497997
74MP0003698_abnormal_male_reproductive0.97208670
75MP0003763_abnormal_thymus_physiology0.96676200
76MP0002116_abnormal_craniofacial_bone0.96645163
77MP0003861_abnormal_nervous_system0.95819205
78MP0001784_abnormal_fluid_regulation0.94769529
79MP0003567_abnormal_fetal_cardiomyocyte0.94002154
80MP0002095_abnormal_skin_pigmentation0.93587975
81MP0005174_abnormal_tail_pigmentation0.93168799
82MP0002006_tumorigenesis0.92986241
83MP0008932_abnormal_embryonic_tissue0.92882882
84MP0002233_abnormal_nose_morphology0.89774679
85MP0004185_abnormal_adipocyte_glucose0.89384849
86MP0002092_abnormal_eye_morphology0.88190731
87MP0009697_abnormal_copulation0.87470316
88MP0003943_abnormal_hepatobiliary_system0.87348455
89MP0002697_abnormal_eye_size0.86211963
90MP0004264_abnormal_extraembryonic_tissu0.85043525
91MP0005410_abnormal_fertilization0.84918014
92MP0008961_abnormal_basal_metabolism0.84874450
93MP0003195_calcinosis0.84159948
94MP0001851_eye_inflammation0.83262633
95MP0002109_abnormal_limb_morphology0.83236827
96MP0001915_intracranial_hemorrhage0.82352242
97MP0000647_abnormal_sebaceous_gland0.82024236
98MP0002081_perinatal_lethality0.81675034
99MP0003878_abnormal_ear_physiology0.81231579
100MP0005377_hearing/vestibular/ear_phenot0.81231579
101MP0003938_abnormal_ear_development0.80591250
102MP0003136_yellow_coat_color0.79518698
103MP0002653_abnormal_ependyma_morphology0.79057050
104MP0001299_abnormal_eye_distance/0.78812460
105MP0003828_pulmonary_edema0.78261516
106MP0000049_abnormal_middle_ear0.77418859
107MP0001879_abnormal_lymphatic_vessel0.76905359
108MP0000427_abnormal_hair_cycle0.76608795
109MP0003880_abnormal_central_pattern0.75919420
110MP0003119_abnormal_digestive_system0.75239758
111MP0002234_abnormal_pharynx_morphology0.75238085
112MP0009278_abnormal_bone_marrow0.74655142
113* MP0002080_prenatal_lethality0.74627740
114MP0003942_abnormal_urinary_system0.74307330
115MP0003045_fibrosis0.74001291
116MP0002177_abnormal_outer_ear0.73887729
117MP0001188_hyperpigmentation0.73804077
118MP0001119_abnormal_female_reproductive0.73295903
119MP0003646_muscle_fatigue0.72310334
120MP0002114_abnormal_axial_skeleton0.72105590
121MP0004142_abnormal_muscle_tone0.72058474
122MP0002928_abnormal_bile_duct0.71745822
123MP0000266_abnormal_heart_morphology0.71014969
124MP0001177_atelectasis0.70962049
125MP0002877_abnormal_melanocyte_morpholog0.70329212
126MP0005367_renal/urinary_system_phenotyp0.69908962
127MP0000516_abnormal_urinary_system0.69908962
128MP0003936_abnormal_reproductive_system0.69651334
129MP0004134_abnormal_chest_morphology0.69625627
130MP0002152_abnormal_brain_morphology0.69507065
131MP0008789_abnormal_olfactory_epithelium0.69290124
132MP0001853_heart_inflammation0.69027636

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.70230921
2Abnormality of the fingertips (HP:0001211)4.38269011
3Long eyelashes (HP:0000527)3.37746004
4Short 4th metacarpal (HP:0010044)3.21866053
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21866053
6Supernumerary ribs (HP:0005815)2.95297708
7Abnormality of the nasal septum (HP:0000419)2.93403519
8Ectopic kidney (HP:0000086)2.88091484
9Lip pit (HP:0100267)2.80046209
10Molar tooth sign on MRI (HP:0002419)2.74316968
11Abnormality of midbrain morphology (HP:0002418)2.74316968
12Papillary thyroid carcinoma (HP:0002895)2.70998477
13Chronic hepatic failure (HP:0100626)2.67083964
14Urethral obstruction (HP:0000796)2.65938149
15Chromsome breakage (HP:0040012)2.60775633
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.59588964
17Narrow palate (HP:0000189)2.59468168
18Meckel diverticulum (HP:0002245)2.55742384
19Supernumerary bones of the axial skeleton (HP:0009144)2.54406932
20Abnormality of the ileum (HP:0001549)2.52580986
21Macroorchidism (HP:0000053)2.49229683
22Increased nuchal translucency (HP:0010880)2.49070308
23Acute myeloid leukemia (HP:0004808)2.48665467
24Septo-optic dysplasia (HP:0100842)2.46899382
25Abnormality of the parietal bone (HP:0002696)2.45278522
26Truncal obesity (HP:0001956)2.43778915
27Hepatoblastoma (HP:0002884)2.41228776
28Nephronophthisis (HP:0000090)2.40175785
29Deep philtrum (HP:0002002)2.38729714
30Diastasis recti (HP:0001540)2.33620196
31Pancreatic cysts (HP:0001737)2.30701768
32Absent frontal sinuses (HP:0002688)2.28783041
33Trigonocephaly (HP:0000243)2.27368969
34Pancreatic fibrosis (HP:0100732)2.26509637
35Clubbing of toes (HP:0100760)2.26054771
36Sloping forehead (HP:0000340)2.23697322
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22053062
38Obsessive-compulsive behavior (HP:0000722)2.21725251
39Medulloblastoma (HP:0002885)2.19577651
40Protruding tongue (HP:0010808)2.18092803
41Abnormality of the 4th metacarpal (HP:0010012)2.17725350
42Abnormality of the renal medulla (HP:0100957)2.15209317
43Abnormality of the preputium (HP:0100587)2.14557068
44Neoplasm of the oral cavity (HP:0100649)2.12456079
45True hermaphroditism (HP:0010459)2.10776875
46Broad thumb (HP:0011304)2.09626710
47Midline defect of the nose (HP:0004122)2.08259559
48Spinal cord lesions (HP:0100561)2.06595179
49Syringomyelia (HP:0003396)2.06595179
50Oligodactyly (hands) (HP:0001180)2.06366864
51Deep palmar crease (HP:0006191)2.06168270
52Limited elbow extension (HP:0001377)2.05816339
53Hyperventilation (HP:0002883)2.05767366
54Facial hemangioma (HP:0000329)2.04404544
55Rib fusion (HP:0000902)2.04026339
56Birth length less than 3rd percentile (HP:0003561)2.02778549
57Drooling (HP:0002307)2.02679292
58Oligodactyly (HP:0012165)2.01040675
59Anal stenosis (HP:0002025)2.00178220
60Myelodysplasia (HP:0002863)2.00019904
61Narrow forehead (HP:0000341)1.99685356
62Prominent nose (HP:0000448)1.98294101
63Acute lymphatic leukemia (HP:0006721)1.96269581
64Impulsivity (HP:0100710)1.96153872
65Abnormality of the incisor (HP:0000676)1.94943820
66Duodenal stenosis (HP:0100867)1.92993420
67Small intestinal stenosis (HP:0012848)1.92993420
68Skull defect (HP:0001362)1.92964889
69Proximal placement of thumb (HP:0009623)1.92405134
70Abnormality of the renal cortex (HP:0011035)1.91149919
71Overlapping toe (HP:0001845)1.90149879
72Long clavicles (HP:0000890)1.90099419
73Deviation of the thumb (HP:0009603)1.88799043
74Triphalangeal thumb (HP:0001199)1.88200443
75Abnormal number of incisors (HP:0011064)1.87991301
76Anophthalmia (HP:0000528)1.87512295
77Excessive salivation (HP:0003781)1.85855848
78Abnormality of DNA repair (HP:0003254)1.84267541
79Shawl scrotum (HP:0000049)1.82912975
80Abnormality of the labia minora (HP:0012880)1.82362438
81Hypoplastic ischia (HP:0003175)1.82224083
82Abnormality of the duodenum (HP:0002246)1.81283424
83Low anterior hairline (HP:0000294)1.81070525
84Aplasia cutis congenita (HP:0001057)1.79555506
85Abnormality of the aortic arch (HP:0012303)1.76936138
86Oligodontia (HP:0000677)1.76252019
87Broad alveolar ridges (HP:0000187)1.76188674
88Tented upper lip vermilion (HP:0010804)1.76139184
89Genetic anticipation (HP:0003743)1.75696087
90Poor coordination (HP:0002370)1.75438430
91Abnormal hair whorl (HP:0010721)1.75432784
92Cutis marmorata (HP:0000965)1.75216393
93Patellar aplasia (HP:0006443)1.75080264
94Nephroblastoma (Wilms tumor) (HP:0002667)1.75048620
95Abnormality of the septum pellucidum (HP:0007375)1.75012422
96Abnormality of incisor morphology (HP:0011063)1.74450017
972-3 toe syndactyly (HP:0004691)1.73941689
98Hypoplastic labia majora (HP:0000059)1.73183197
99Abnormality of the carotid arteries (HP:0005344)1.72996474
100Tubular atrophy (HP:0000092)1.71813357
101Thick eyebrow (HP:0000574)1.71641599
102Transitional cell carcinoma of the bladder (HP:0006740)1.71197472
103Hypoplastic iliac wings (HP:0002866)1.70937647
104Intestinal atresia (HP:0011100)1.70165058
105Morphological abnormality of the inner ear (HP:0011390)1.70094342
106Embryonal neoplasm (HP:0002898)1.69301417
107Broad phalanges of the hand (HP:0009768)1.68768967
108Depressed nasal tip (HP:0000437)1.67516481
109Bifid tongue (HP:0010297)1.67493140
110Abnormality of chromosome stability (HP:0003220)1.67184715
111Abnormality of the ischium (HP:0003174)1.67013743
112Hip dysplasia (HP:0001385)1.66920945
113Abnormality of the columella (HP:0009929)1.66491882
114Highly arched eyebrow (HP:0002553)1.65860376
115Heterotopia (HP:0002282)1.65846182
116Small hand (HP:0200055)1.65624702
117Abnormality of chromosome segregation (HP:0002916)1.65584238
118Cupped ear (HP:0000378)1.65574698
119Asymmetry of the thorax (HP:0001555)1.65528505
120Hypoplasia of the maxilla (HP:0000327)1.65435428
121Broad-based gait (HP:0002136)1.65166740
122Abnormality of cochlea (HP:0000375)1.64806875
123Microtia (HP:0008551)1.64575795
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.63543609
125Absent/shortened dynein arms (HP:0200106)1.63543609
126Increased number of teeth (HP:0011069)1.63502358
127Thin upper lip vermilion (HP:0000219)1.63016451
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.61967523
129Microglossia (HP:0000171)1.60268863
130Sandal gap (HP:0001852)1.60073774
131Smooth philtrum (HP:0000319)1.59109751
132Broad finger (HP:0001500)1.59005608
133Neoplasm of striated muscle (HP:0009728)1.58808983
134Sparse lateral eyebrow (HP:0005338)1.58364579
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.58279179
136Abnormality of the phalanges of the hallux (HP:0010057)1.57913630
137Sparse scalp hair (HP:0002209)1.57854797
138Colon cancer (HP:0003003)1.57732996
139Bladder neoplasm (HP:0009725)1.57656996
140Bladder carcinoma (HP:0002862)1.57656996
141Embryonal renal neoplasm (HP:0011794)1.57029227
142Gastrointestinal carcinoma (HP:0002672)1.56522997
143Malignant gastrointestinal tract tumors (HP:0006749)1.56522997
144Widely spaced teeth (HP:0000687)1.56207128
145Ependymoma (HP:0002888)1.55858212
146Vertebral arch anomaly (HP:0008438)1.55644754
147Abnormality of the intervertebral disk (HP:0005108)1.54709949
148Abnormality of the labia majora (HP:0012881)1.54237560
149Glioma (HP:0009733)1.54103542
150Dislocated radial head (HP:0003083)1.53652010
151Intestinal malrotation (HP:0002566)1.53601067
152Astrocytoma (HP:0009592)1.53153164
153Abnormality of the astrocytes (HP:0100707)1.53153164
154Rhabdomyosarcoma (HP:0002859)1.53100626
155Basal cell carcinoma (HP:0002671)1.50458377
156Broad phalanx (HP:0006009)1.50454250
157Chin dimple (HP:0010751)1.49111502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.73344471
2CDC73.29775540
3LATS13.24864049
4BRD43.19259614
5WEE13.11126016
6NUAK12.74019920
7CAMK1G2.64006324
8MKNK22.49302497
9TNIK2.33708614
10PNCK2.30758326
11STK32.20404451
12CAMK1D2.09334705
13MKNK12.08163354
14DMPK1.72486055
15SIK21.70991384
16MAPK131.59776792
17CDK91.52716496
18WNK31.49070157
19NEK21.47977489
20BMPR1B1.42509750
21FGFR21.42107676
22CASK1.40967030
23ATM1.36258911
24CDK61.35028309
25CHEK11.34647271
26CDK31.33676971
27FGFR31.33340437
28ATR1.30525997
29STK241.26914731
30TAF11.26377017
31ACVR1B1.23757765
32CHEK21.22805848
33PDGFRB1.18183713
34MTOR1.16364052
35SIK31.14963536
36CDK71.14166746
37MAP3K101.13848096
38SRPK11.13835862
39PLK31.11406004
40WNK11.10457623
41JAK31.08718946
42STK101.07492990
43MARK31.06044471
44UHMK11.04359319
45CLK11.04247910
46MELK1.02379746
47ICK1.01683632
48CDK41.00985624
49MAPK150.97671602
50ALK0.94656068
51* CDK20.94621653
52TTK0.92697885
53PRKD30.91136723
54* CDK10.86242968
55MAPK140.83733525
56EPHA30.78870545
57FRK0.78801115
58CSNK1D0.77938967
59BRSK20.77163269
60EIF2AK20.77079582
61CHUK0.76431277
62RPS6KA40.76175699
63STK40.75396240
64INSRR0.75262185
65TYRO30.73846399
66PASK0.72875551
67* GSK3B0.72144918
68DYRK1A0.71468781
69CSNK1E0.71363878
70SGK20.71040195
71MAPK100.70856882
72PKN10.70789476
73PRKDC0.69741437
74SGK30.64438359
75DYRK30.62663676
76MARK20.62466079
77SGK10.59752076
78STK38L0.59403161
79TXK0.59012591
80PLK10.57111601
81NLK0.57108527
82MAPK10.55752872
83MAP3K60.55557680
84HIPK20.55328940
85RPS6KB10.54215776
86EIF2AK30.53629341
87MAPK80.52970762
88AURKB0.52826124
89PLK40.51811824
90PLK20.51010067
91SGK4940.50973009
92SGK2230.50973009
93YES10.50442258
94AKT30.50342480
95ZAK0.49015426
96LATS20.48897583
97AKT10.48679947
98CDK80.48408971
99EIF2AK10.48029570
100VRK10.47415290
101TGFBR10.46935671
102FGFR10.46250997
103CSNK1A1L0.45616385
104MAP4K10.44915660
105ITK0.44860014
106PRKD20.44451043
107PRKCQ0.44417231
108EPHB10.44279529
109NEK60.44188800
110PIK3CA0.43786825
111RPS6KB20.43184853
112ERBB30.42776358
113PIM10.42730795
114CDC42BPA0.42714420
115STK110.42210328
116MAP3K40.41527369
117CAMK40.41512527
118PDGFRA0.40893357
119WNK40.40093092
120PAK20.39900992
121PRKCH0.39359262
122PTK60.38623317
123BUB10.38554632
124TAOK30.38410961
125IRAK10.37115936
126BRSK10.36964261
127TEC0.36837187
128HCK0.36743124
129STK390.36406615
130PRKAA20.35162891
131CSNK2A20.34194459
132MAP3K90.34137622
133TAOK10.34134831
134RPS6KA30.33838563
135CAMK10.33455298
136CDK190.32198648

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.33753815
2mRNA surveillance pathway_Homo sapiens_hsa030152.21432835
3Fanconi anemia pathway_Homo sapiens_hsa034601.88666894
4Lysine degradation_Homo sapiens_hsa003101.87491684
5Cell cycle_Homo sapiens_hsa041101.71370953
6MicroRNAs in cancer_Homo sapiens_hsa052061.68753725
7Basal transcription factors_Homo sapiens_hsa030221.63676478
8Dorso-ventral axis formation_Homo sapiens_hsa043201.63240817
9Protein export_Homo sapiens_hsa030601.57322458
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51031385
11Spliceosome_Homo sapiens_hsa030401.49560956
12RNA transport_Homo sapiens_hsa030131.49010023
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45772173
14Non-homologous end-joining_Homo sapiens_hsa034501.39267326
15Prostate cancer_Homo sapiens_hsa052151.39005267
16Adherens junction_Homo sapiens_hsa045201.38000392
17Homologous recombination_Homo sapiens_hsa034401.36568275
18Basal cell carcinoma_Homo sapiens_hsa052171.31943937
19Wnt signaling pathway_Homo sapiens_hsa043101.31140280
20RNA polymerase_Homo sapiens_hsa030201.29056931
21RNA degradation_Homo sapiens_hsa030181.27584645
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27259432
23Chronic myeloid leukemia_Homo sapiens_hsa052201.24901220
24One carbon pool by folate_Homo sapiens_hsa006701.24253874
25B cell receptor signaling pathway_Homo sapiens_hsa046621.23838677
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23520718
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22969143
28Herpes simplex infection_Homo sapiens_hsa051681.22434474
29T cell receptor signaling pathway_Homo sapiens_hsa046601.17754868
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17318831
31Circadian rhythm_Homo sapiens_hsa047101.16932212
32Primary immunodeficiency_Homo sapiens_hsa053401.16074842
33HTLV-I infection_Homo sapiens_hsa051661.15004745
34Non-small cell lung cancer_Homo sapiens_hsa052231.11786993
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.11617778
36TGF-beta signaling pathway_Homo sapiens_hsa043501.11262351
37Long-term potentiation_Homo sapiens_hsa047201.10945458
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10417627
39Small cell lung cancer_Homo sapiens_hsa052221.08730576
40Endometrial cancer_Homo sapiens_hsa052131.07522326
41Colorectal cancer_Homo sapiens_hsa052101.06141618
42Oocyte meiosis_Homo sapiens_hsa041141.05142249
43Base excision repair_Homo sapiens_hsa034101.05042852
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04584810
45Renal cell carcinoma_Homo sapiens_hsa052111.02299150
46Pancreatic cancer_Homo sapiens_hsa052121.01422753
47Glioma_Homo sapiens_hsa052141.01404170
48Notch signaling pathway_Homo sapiens_hsa043300.99685256
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99166622
50Hedgehog signaling pathway_Homo sapiens_hsa043400.98447821
51FoxO signaling pathway_Homo sapiens_hsa040680.97982921
52Proteoglycans in cancer_Homo sapiens_hsa052050.95176294
53Hippo signaling pathway_Homo sapiens_hsa043900.93819405
54Viral myocarditis_Homo sapiens_hsa054160.93264607
55Mismatch repair_Homo sapiens_hsa034300.92616728
56Pathways in cancer_Homo sapiens_hsa052000.92355164
57MAPK signaling pathway_Homo sapiens_hsa040100.92127534
58mTOR signaling pathway_Homo sapiens_hsa041500.91433729
59Choline metabolism in cancer_Homo sapiens_hsa052310.90585408
60Hepatitis B_Homo sapiens_hsa051610.90515529
61ErbB signaling pathway_Homo sapiens_hsa040120.89011599
62Ribosome_Homo sapiens_hsa030100.87602200
63Acute myeloid leukemia_Homo sapiens_hsa052210.87312716
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86271407
65Estrogen signaling pathway_Homo sapiens_hsa049150.84976960
66Osteoclast differentiation_Homo sapiens_hsa043800.83621814
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83558349
68Viral carcinogenesis_Homo sapiens_hsa052030.82427244
69Selenocompound metabolism_Homo sapiens_hsa004500.82211244
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81775777
71Type II diabetes mellitus_Homo sapiens_hsa049300.81751234
72Thyroid cancer_Homo sapiens_hsa052160.81727299
73Measles_Homo sapiens_hsa051620.80829347
74Regulation of autophagy_Homo sapiens_hsa041400.79728488
75Axon guidance_Homo sapiens_hsa043600.79601421
76Steroid biosynthesis_Homo sapiens_hsa001000.78046202
77Propanoate metabolism_Homo sapiens_hsa006400.77725077
78Melanogenesis_Homo sapiens_hsa049160.77353423
79p53 signaling pathway_Homo sapiens_hsa041150.76493134
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.75874440
81Renin secretion_Homo sapiens_hsa049240.75511302
82Inositol phosphate metabolism_Homo sapiens_hsa005620.74899871
83Amphetamine addiction_Homo sapiens_hsa050310.74850987
84Antigen processing and presentation_Homo sapiens_hsa046120.73534312
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73156151
86Phototransduction_Homo sapiens_hsa047440.72911824
87Prolactin signaling pathway_Homo sapiens_hsa049170.71573288
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.71477334
89Toxoplasmosis_Homo sapiens_hsa051450.70462863
90Influenza A_Homo sapiens_hsa051640.70437717
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70221105
92Epstein-Barr virus infection_Homo sapiens_hsa051690.70160022
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69352582
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69139740
95cAMP signaling pathway_Homo sapiens_hsa040240.69120196
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69054603
97Focal adhesion_Homo sapiens_hsa045100.68408317
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68249774
99Long-term depression_Homo sapiens_hsa047300.68018708
100Platelet activation_Homo sapiens_hsa046110.67710423
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66299372
102Melanoma_Homo sapiens_hsa052180.65549646
103GnRH signaling pathway_Homo sapiens_hsa049120.64738795
104Rap1 signaling pathway_Homo sapiens_hsa040150.64033378
105Nicotine addiction_Homo sapiens_hsa050330.63986425
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63039438
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62904820
108Hematopoietic cell lineage_Homo sapiens_hsa046400.62717153
109ECM-receptor interaction_Homo sapiens_hsa045120.62254239
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.61341920
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59358847
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59326515
113Nucleotide excision repair_Homo sapiens_hsa034200.59168777
114Oxytocin signaling pathway_Homo sapiens_hsa049210.58379731
115Ras signaling pathway_Homo sapiens_hsa040140.58115670
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56901722
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47796245
118Taste transduction_Homo sapiens_hsa047420.47229775
119Olfactory transduction_Homo sapiens_hsa047400.44789550
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41093166
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.40937121
122Linoleic acid metabolism_Homo sapiens_hsa005910.37954121
123Purine metabolism_Homo sapiens_hsa002300.37813356
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36005733
125TNF signaling pathway_Homo sapiens_hsa046680.35930324
126Fatty acid biosynthesis_Homo sapiens_hsa000610.32165283

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