RBBP8NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)6.89161641
2hemidesmosome assembly (GO:0031581)5.84639408
3positive regulation of Cdc42 GTPase activity (GO:0043089)5.79253525
4interferon-gamma secretion (GO:0072643)5.28130031
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.09140604
6semaphorin-plexin signaling pathway (GO:0071526)5.06717252
7desmosome organization (GO:0002934)5.05505849
8polarized epithelial cell differentiation (GO:0030859)5.00956215
9establishment of apical/basal cell polarity (GO:0035089)4.95422147
10negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.89543590
11negative regulation of cell size (GO:0045792)4.88262773
12ear development (GO:0043583)4.83966251
13regulation of hippo signaling (GO:0035330)4.76998192
14nephron tubule formation (GO:0072079)4.64819904
15activation of Rac GTPase activity (GO:0032863)4.48088336
16regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.45253605
17regulation of posttranscriptional gene silencing (GO:0060147)4.38537548
18regulation of gene silencing by miRNA (GO:0060964)4.38537548
19regulation of gene silencing by RNA (GO:0060966)4.38537548
20positive regulation of SMAD protein import into nucleus (GO:0060391)4.34972760
21cell migration involved in gastrulation (GO:0042074)4.34553745
22peptidyl-tyrosine autophosphorylation (GO:0038083)4.31860378
23nodal signaling pathway (GO:0038092)4.28669470
24regulation of ruffle assembly (GO:1900027)4.20361217
25paraxial mesoderm development (GO:0048339)4.19629083
26regulation of water loss via skin (GO:0033561)4.17997639
27hepatocyte apoptotic process (GO:0097284)4.16154730
28ectoderm development (GO:0007398)4.13458557
29establishment or maintenance of monopolar cell polarity (GO:0061339)4.08575057
30establishment of monopolar cell polarity (GO:0061162)4.08575057
31maternal placenta development (GO:0001893)3.98902011
32trophectodermal cell differentiation (GO:0001829)3.94137015
33positive regulation of cellular amine metabolic process (GO:0033240)3.92373017
34regulation of SMAD protein import into nucleus (GO:0060390)3.90889155
35epithelial cell differentiation involved in prostate gland development (GO:0060742)3.80877004
36embryonic process involved in female pregnancy (GO:0060136)3.80474464
37endothelial cell chemotaxis (GO:0035767)3.75922533
38lung morphogenesis (GO:0060425)3.73156538
39epithelial cell-cell adhesion (GO:0090136)3.72240609
40tight junction assembly (GO:0070830)3.64791245
41anterior/posterior axis specification, embryo (GO:0008595)3.63512735
42regulation of hydrogen peroxide metabolic process (GO:0010310)3.63026486
43regulation of histone H3-K27 methylation (GO:0061085)3.62783897
44establishment of skin barrier (GO:0061436)3.61963654
45GDP-mannose metabolic process (GO:0019673)3.61836414
46mesonephros development (GO:0001823)3.60198596
47regulation of Cdc42 GTPase activity (GO:0043088)3.59681032
48positive regulation of keratinocyte differentiation (GO:0045618)3.57488846
49morphogenesis of embryonic epithelium (GO:0016331)3.56763490
50regulation of cell proliferation involved in kidney development (GO:1901722)3.53381953
51COPI coating of Golgi vesicle (GO:0048205)3.44259786
52Golgi transport vesicle coating (GO:0048200)3.44259786
53positive regulation of epidermal cell differentiation (GO:0045606)3.42959357
54establishment or maintenance of apical/basal cell polarity (GO:0035088)3.42703414
55establishment or maintenance of bipolar cell polarity (GO:0061245)3.42703414
56insulin-like growth factor receptor signaling pathway (GO:0048009)3.40838985
57calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.37668168
58positive regulation of histone deacetylation (GO:0031065)3.35363162
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32810031
60establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.31695136
61response to food (GO:0032094)3.27515830
62planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27077111
63regulation of fatty acid beta-oxidation (GO:0031998)3.26731729
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.26695285
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26426018
66face development (GO:0060324)3.23164864
67regulation of cholesterol biosynthetic process (GO:0045540)3.21296741
68regulation of interleukin-13 production (GO:0032656)3.20561509
69cell-cell junction maintenance (GO:0045217)3.17558215
70negative regulation of cell fate specification (GO:0009996)3.15771820
71notochord development (GO:0030903)3.11960608
72regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.08156838
73branching involved in salivary gland morphogenesis (GO:0060445)3.06925427
74hippo signaling (GO:0035329)3.06725832
75negative regulation of keratinocyte proliferation (GO:0010839)3.06094771
76regulation of establishment or maintenance of cell polarity (GO:0032878)3.05839095
77cornea development in camera-type eye (GO:0061303)3.04649217
78keratinocyte development (GO:0003334)3.03453581
79proline metabolic process (GO:0006560)3.01167283
80striated muscle atrophy (GO:0014891)3.00428587
81regulation of clathrin-mediated endocytosis (GO:2000369)3.00418082
82lung-associated mesenchyme development (GO:0060484)3.00279050
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99189386
84formation of translation preinitiation complex (GO:0001731)2.98450817
85morphogenesis of an epithelial fold (GO:0060571)2.97638869
86regulation of cardioblast proliferation (GO:0003264)2.97170061
87regulation of secondary heart field cardioblast proliferation (GO:0003266)2.97170061
88glutathione biosynthetic process (GO:0006750)2.96345161
89cell differentiation involved in embryonic placenta development (GO:0060706)2.96307558
90folic acid-containing compound biosynthetic process (GO:0009396)2.95875013
91phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.95787202
92biotin metabolic process (GO:0006768)2.95687782
93positive regulation of fatty acid beta-oxidation (GO:0032000)2.93031895
94positive regulation of pseudopodium assembly (GO:0031274)2.93014871
95regulation of translational fidelity (GO:0006450)2.92277631
96Rho protein signal transduction (GO:0007266)2.89567677
97negative regulation of cell fate commitment (GO:0010454)2.89424583
98cell-substrate junction assembly (GO:0007044)2.87868854
99establishment of epithelial cell polarity (GO:0090162)2.87098394
100aorta morphogenesis (GO:0035909)2.86086221
101NADH metabolic process (GO:0006734)2.85299045
102positive regulation of protein kinase C signaling (GO:0090037)2.83699810
103apoptotic process involved in morphogenesis (GO:0060561)2.83695760
104amyloid precursor protein catabolic process (GO:0042987)2.83174100
105protein retention in ER lumen (GO:0006621)2.82969388
106cardiac right ventricle morphogenesis (GO:0003215)2.81753993
107adherens junction assembly (GO:0034333)2.80913584
108pre-miRNA processing (GO:0031054)2.79097085
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77491600
110multicellular organismal water homeostasis (GO:0050891)2.76401289
111columnar/cuboidal epithelial cell development (GO:0002066)2.74915580
112water homeostasis (GO:0030104)2.74819378
113regulation of keratinocyte differentiation (GO:0045616)2.74418589
114establishment of planar polarity (GO:0001736)2.74205981
115establishment of tissue polarity (GO:0007164)2.74205981
116mesodermal cell differentiation (GO:0048333)2.74129440
117mannose metabolic process (GO:0006013)2.73765886
118epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72714489
119regulation of chromatin binding (GO:0035561)2.71497845
120outflow tract septum morphogenesis (GO:0003148)2.71229490
121lung lobe morphogenesis (GO:0060463)2.70974387
122cell-substrate adherens junction assembly (GO:0007045)2.68629168
123focal adhesion assembly (GO:0048041)2.68629168
124regulation of cholesterol metabolic process (GO:0090181)2.68039482
125norepinephrine metabolic process (GO:0042415)2.67681656
126negative regulation of androgen receptor signaling pathway (GO:0060766)2.67490117
127regulation of cell fate specification (GO:0042659)2.66569083
128positive regulation of hormone metabolic process (GO:0032352)2.66088998
129negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.62072073
130positive regulation of epidermis development (GO:0045684)2.61551701
131embryonic foregut morphogenesis (GO:0048617)2.60952703
132nonribosomal peptide biosynthetic process (GO:0019184)2.60650720
133skeletal muscle adaptation (GO:0043501)2.60504807
134intestinal absorption (GO:0050892)2.60334989
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.60101124
136activation of Rho GTPase activity (GO:0032862)2.59054496
137actin filament bundle organization (GO:0061572)2.58648393
138actin filament bundle assembly (GO:0051017)2.58648393
139positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.58487702
140nitric oxide biosynthetic process (GO:0006809)2.58359149
141lung epithelium development (GO:0060428)2.58296719
142atrioventricular valve morphogenesis (GO:0003181)2.58125770
143flavonoid metabolic process (GO:0009812)2.56985276
144asymmetric protein localization (GO:0008105)2.56967290
145pharyngeal system development (GO:0060037)2.56942783
146bone morphogenesis (GO:0060349)2.56435484
147regulation of interleukin-5 production (GO:0032674)2.56211706
148negative regulation of fatty acid transport (GO:2000192)2.55830311
149regulation of stem cell maintenance (GO:2000036)2.55548329
150pattern specification involved in kidney development (GO:0061004)2.55356590
151cell-cell junction assembly (GO:0007043)2.54298465
152negative regulation of chondrocyte differentiation (GO:0032331)2.54279940
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53622357
154sphingomyelin metabolic process (GO:0006684)2.53509707
155positive regulation of odontogenesis (GO:0042482)2.52248087
156trivalent inorganic anion homeostasis (GO:0072506)2.52092842
157phosphate ion homeostasis (GO:0055062)2.52092842
158renal system development (GO:0072001)2.52075022
159digestive tract morphogenesis (GO:0048546)2.50231888
160ectodermal placode formation (GO:0060788)2.47372306
161keratinocyte differentiation (GO:0030216)2.46027908
162regulation of pseudopodium assembly (GO:0031272)2.45851952
163pentose-phosphate shunt (GO:0006098)2.44743120
164regulation of sister chromatid cohesion (GO:0007063)2.43965314
165regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.43651854
166branching involved in prostate gland morphogenesis (GO:0060442)2.43511217
167proline biosynthetic process (GO:0006561)2.43399786
168outer ear morphogenesis (GO:0042473)2.42648529
169dorsal/ventral axis specification (GO:0009950)2.42187075
170branching involved in labyrinthine layer morphogenesis (GO:0060670)2.40970106
171type B pancreatic cell proliferation (GO:0044342)2.40624794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.91424649
2POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.19910788
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.09967770
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.09967770
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.09967770
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.96551362
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.87666530
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.83604300
9E2F7_22180533_ChIP-Seq_HELA_Human2.78873604
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73640898
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.42700298
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40891312
13AR_21909140_ChIP-Seq_LNCAP_Human2.40554233
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.40339321
15ZNF263_19887448_ChIP-Seq_K562_Human2.34574034
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.29600018
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.26528196
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.24313487
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22449140
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.19795849
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.11445346
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10706521
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.08973956
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02380215
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.00715498
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.97360537
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.97290913
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96054344
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91795672
30GATA6_25053715_ChIP-Seq_YYC3_Human1.90908973
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87682101
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86999463
33P68_20966046_ChIP-Seq_HELA_Human1.86740765
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86715069
35RACK7_27058665_Chip-Seq_MCF-7_Human1.85578314
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84697820
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83912383
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83789594
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.82845279
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81785740
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.81463316
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81355436
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75987755
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.75980336
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73688692
46SMC4_20622854_ChIP-Seq_HELA_Human1.69756576
47VDR_21846776_ChIP-Seq_THP-1_Human1.68965307
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68618059
49TCF7_22412390_ChIP-Seq_EML_Mouse1.68040374
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.65564778
51ATF3_27146783_Chip-Seq_COLON_Human1.64253721
52GATA4_25053715_ChIP-Seq_YYC3_Human1.62529124
53* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60873001
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60214899
55KDM2B_26808549_Chip-Seq_K562_Human1.58278523
56KDM2B_26808549_Chip-Seq_DND41_Human1.57751176
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.57498982
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.57455930
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56841619
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54863147
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51516899
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50156758
63CTCF_27219007_Chip-Seq_Bcells_Human1.48250398
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47642126
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.46259976
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46191681
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.44352249
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44158995
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43759161
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43759039
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43759039
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42068365
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41523273
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40689194
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38311535
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37702537
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37222162
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36394514
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35901959
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35523548
81NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33658375
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33391435
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32235156
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30737899
85CLOCK_20551151_ChIP-Seq_293T_Human1.29787571
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29306303
87TP63_22573176_ChIP-Seq_HFKS_Human1.28724248
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27832233
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27727152
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27379795
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26387137
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24504563
93BCOR_27268052_Chip-Seq_Bcells_Human1.24498550
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24016879
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22689140
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20123609
97TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18951275
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18900320
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17692805
100RARB_24833708_ChIP-Seq_LIVER_Mouse1.17654737
101CHD1_26751641_Chip-Seq_LNCaP_Human1.17281152
102NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17275483
103KLF5_25053715_ChIP-Seq_YYC3_Human1.17042832
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16598180
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16356520
106GATA3_24758297_ChIP-Seq_MCF-7_Human1.16081790
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14813988
108RXR_22158963_ChIP-Seq_LIVER_Mouse1.14231776
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14015061
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13663577
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12098066
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11207226
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10762098
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10643881
115SOX2_20726797_ChIP-Seq_SW620_Human1.10611259
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09719668
117E2F1_20622854_ChIP-Seq_HELA_Human1.08190852
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08090217
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08012023
120BCL6_27268052_Chip-Seq_Bcells_Human1.07444606
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.07444119
122SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07331843
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.06959885
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06916621
125MYC_22102868_ChIP-Seq_BL_Human1.05198303
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.04160784
127AHR_22903824_ChIP-Seq_MCF-7_Human1.02771480
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02730193
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.02101596
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01344611
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01080688
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01063183
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00510843
134PHF8_20622854_ChIP-Seq_HELA_Human1.00509084
135CREB1_26743006_Chip-Seq_LNCaP_Human1.00358035
136TP53_22127205_ChIP-Seq_IMR90_Human1.00083163
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99662365
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99623879
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.98881166
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.98374898
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97705738
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.96986377
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96942305
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96396243
145MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96362429
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.96210940
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96162434
148DROSHA_22980978_ChIP-Seq_HELA_Human0.95983785
149SA1_27219007_Chip-Seq_Bcells_Human0.95895440
150NCOR1_26117541_ChIP-Seq_K562_Human0.95647012
151PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95556527
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95458875
153PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94405555
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93527129
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92960704
156LXR_22292898_ChIP-Seq_THP-1_Human0.92557195
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92399872
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.92140972
159XRN2_22483619_ChIP-Seq_HELA_Human0.88546295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.47787594
2MP0000537_abnormal_urethra_morphology3.97348537
3MP0004264_abnormal_extraembryonic_tissu3.49330044
4MP0010352_gastrointestinal_tract_polyps3.06731964
5MP0003705_abnormal_hypodermis_morpholog2.90397555
6MP0002796_impaired_skin_barrier2.89754905
7MP0002254_reproductive_system_inflammat2.64479812
8MP0005360_urolithiasis2.37874194
9MP0001849_ear_inflammation2.37124745
10MP0010678_abnormal_skin_adnexa2.35156858
11MP0005058_abnormal_lysosome_morphology2.25859793
12MP0000462_abnormal_digestive_system2.23710915
13MP0003283_abnormal_digestive_organ2.17902498
14MP0002098_abnormal_vibrissa_morphology2.15442950
15MP0010030_abnormal_orbit_morphology2.12356418
16MP0004381_abnormal_hair_follicle2.10159831
17MP0001666_abnormal_nutrient_absorption2.05535774
18MP0009384_cardiac_valve_regurgitation2.00921491
19MP0000762_abnormal_tongue_morphology1.94988287
20MP0005501_abnormal_skin_physiology1.93975994
21MP0003566_abnormal_cell_adhesion1.89342831
22MP0005409_darkened_coat_color1.89160971
23MP0008260_abnormal_autophagy1.88549008
24MP0002822_catalepsy1.87169231
25MP0003693_abnormal_embryo_hatching1.86825339
26MP0005451_abnormal_body_composition1.83593287
27MP0003119_abnormal_digestive_system1.80883603
28MP0000566_synostosis1.79831273
29MP0009053_abnormal_anal_canal1.78023709
30MP0004858_abnormal_nervous_system1.73052674
31MP0004957_abnormal_blastocyst_morpholog1.71641456
32MP0000383_abnormal_hair_follicle1.69712337
33MP0000678_abnormal_parathyroid_gland1.67288144
34MP0005499_abnormal_olfactory_system1.67213576
35MP0005394_taste/olfaction_phenotype1.67213576
36MP0000579_abnormal_nail_morphology1.63970107
37MP0005377_hearing/vestibular/ear_phenot1.60962839
38MP0003878_abnormal_ear_physiology1.60962839
39MP0003941_abnormal_skin_development1.60280153
40MP0004133_heterotaxia1.59176724
41MP0004782_abnormal_surfactant_physiolog1.57494985
42MP0005275_abnormal_skin_tensile1.57378581
43MP0001346_abnormal_lacrimal_gland1.56676039
44MP0003315_abnormal_perineum_morphology1.55064906
45MP0001881_abnormal_mammary_gland1.52212750
46MP0003453_abnormal_keratinocyte_physiol1.50610714
47MP0004272_abnormal_basement_membrane1.49942079
48MP0009780_abnormal_chondrocyte_physiolo1.49838169
49MP0008789_abnormal_olfactory_epithelium1.49181521
50MP0005076_abnormal_cell_differentiation1.46302700
51MP0005670_abnormal_white_adipose1.43774971
52MP0001216_abnormal_epidermal_layer1.43692475
53MP0003183_abnormal_peptide_metabolism1.43400959
54MP0003172_abnormal_lysosome_physiology1.42735900
55MP0008004_abnormal_stomach_pH1.39089429
56MP0002060_abnormal_skin_morphology1.38941518
57MP0000467_abnormal_esophagus_morphology1.38838099
58MP0000627_abnormal_mammary_gland1.34198524
59MP0003879_abnormal_hair_cell1.33546449
60MP0005666_abnormal_adipose_tissue1.33043894
61MP0001765_abnormal_ion_homeostasis1.32403395
62MP0003890_abnormal_embryonic-extraembry1.32041630
63MP0000377_abnormal_hair_follicle1.29761819
64MP0000534_abnormal_ureter_morphology1.29122763
65MP0001348_abnormal_lacrimal_gland1.27491955
66MP0000470_abnormal_stomach_morphology1.26998857
67MP0000613_abnormal_salivary_gland1.26748702
68MP0001730_embryonic_growth_arrest1.25274231
69MP0003937_abnormal_limbs/digits/tail_de1.24702842
70MP0002084_abnormal_developmental_patter1.22494942
71MP0002653_abnormal_ependyma_morphology1.22382034
72MP0005023_abnormal_wound_healing1.20795266
73MP0000490_abnormal_crypts_of1.20404015
74MP0002085_abnormal_embryonic_tissue1.20049188
75MP0000538_abnormal_urinary_bladder1.18538905
76MP0002111_abnormal_tail_morphology1.18401256
77MP0001873_stomach_inflammation1.16567482
78MP0000477_abnormal_intestine_morphology1.16409539
79MP0002234_abnormal_pharynx_morphology1.15045360
80MP0000350_abnormal_cell_proliferation1.14059573
81MP0006138_congestive_heart_failure1.12978657
82MP0001672_abnormal_embryogenesis/_devel1.12832873
83MP0005380_embryogenesis_phenotype1.12832873
84MP0000516_abnormal_urinary_system1.12685298
85MP0005367_renal/urinary_system_phenotyp1.12685298
86MP0002086_abnormal_extraembryonic_tissu1.12615788
87MP0004019_abnormal_vitamin_homeostasis1.12503730
88MP0005375_adipose_tissue_phenotype1.11554884
89MP0009931_abnormal_skin_appearance1.05810183
90MP0004197_abnormal_fetal_growth/weight/1.05796392
91MP0000003_abnormal_adipose_tissue1.05709348
92MP0009379_abnormal_foot_pigmentation1.05404393
93MP0003111_abnormal_nucleus_morphology1.04015454
94MP0002233_abnormal_nose_morphology1.03529502
95MP0006054_spinal_hemorrhage1.01970912
96MP0001664_abnormal_digestion1.00849196
97MP0003942_abnormal_urinary_system1.00422253
98MP0005083_abnormal_biliary_tract1.00264960
99MP0010771_integument_phenotype0.99666140
100MP0000049_abnormal_middle_ear0.97934871
101MP0000647_abnormal_sebaceous_gland0.96230265
102MP0001697_abnormal_embryo_size0.95713662
103MP0003077_abnormal_cell_cycle0.94697418
104MP0002088_abnormal_embryonic_growth/wei0.94404143
105MP0009672_abnormal_birth_weight0.94035837
106MP0003984_embryonic_growth_retardation0.93643252
107MP0009643_abnormal_urine_homeostasis0.93435827
108MP0001764_abnormal_homeostasis0.91688215
109MP0003300_gastrointestinal_ulcer0.90722393
110MP0000428_abnormal_craniofacial_morphol0.90044156
111MP0000427_abnormal_hair_cycle0.89187753
112MP0002249_abnormal_larynx_morphology0.89093729
113MP0000681_abnormal_thyroid_gland0.88988041
114MP0002089_abnormal_postnatal_growth/wei0.88654663
115MP0000432_abnormal_head_morphology0.88496757
116MP0003123_paternal_imprinting0.87963961
117MP0009840_abnormal_foam_cell0.87690530
118MP0005381_digestive/alimentary_phenotyp0.85112651
119MP0003718_maternal_effect0.84838651
120MP0002932_abnormal_joint_morphology0.81700934
121MP0004947_skin_inflammation0.80879406
122MP0002080_prenatal_lethality0.79914405
123MP0005187_abnormal_penis_morphology0.78787017
124MP0000367_abnormal_coat/_hair0.77914720
125MP0003755_abnormal_palate_morphology0.76500445
126MP0004185_abnormal_adipocyte_glucose0.76448556
127MP0003806_abnormal_nucleotide_metabolis0.76331684
128MP0003935_abnormal_craniofacial_develop0.76273007
129MP0001286_abnormal_eye_development0.75336744
130MP0002166_altered_tumor_susceptibility0.75214709
131MP0003866_abnormal_defecation0.73057515
132MP0000858_altered_metastatic_potential0.72880572
133MP0003191_abnormal_cellular_cholesterol0.71254490
134MP0003936_abnormal_reproductive_system0.71191856
135MP0003115_abnormal_respiratory_system0.70264309
136MP0005220_abnormal_exocrine_pancreas0.69344536
137MP0001340_abnormal_eyelid_morphology0.68316244
138MP0003638_abnormal_response/metabolism_0.67942920
139MP0005365_abnormal_bile_salt0.64611591
140MP0003938_abnormal_ear_development0.63715929
141MP0002970_abnormal_white_adipose0.63507180
142MP0002896_abnormal_bone_mineralization0.61056474
143MP0002116_abnormal_craniofacial_bone0.60188877
144MP0005636_abnormal_mineral_homeostasis0.59829982
145MP0001727_abnormal_embryo_implantation0.58462919
146MP0000733_abnormal_muscle_development0.58258974
147MP0005410_abnormal_fertilization0.57036641
148MP0010329_abnormal_lipoprotein_level0.52675899
149MP0005085_abnormal_gallbladder_physiolo0.52349111

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)6.44280651
2Onycholysis (HP:0001806)5.44892663
3Pili torti (HP:0003777)5.39053484
4Right ventricular cardiomyopathy (HP:0011663)5.19800959
5Milia (HP:0001056)5.08277215
6Broad face (HP:0000283)5.08236792
7Cervical subluxation (HP:0003308)4.97836570
8Obstructive sleep apnea (HP:0002870)4.34688041
9Septate vagina (HP:0001153)4.15868075
10Atrophic scars (HP:0001075)4.07804362
11Lip pit (HP:0100267)3.87085068
12Thin bony cortex (HP:0002753)3.79558072
13Stridor (HP:0010307)3.77324369
14Amelogenesis imperfecta (HP:0000705)3.75853488
15Lymphangioma (HP:0100764)3.73664058
16Micronodular cirrhosis (HP:0001413)3.58544555
17Fragile nails (HP:0001808)3.48696751
18Deformed sella turcica (HP:0002681)3.45249037
19Abnormality of cochlea (HP:0000375)3.40483395
20Plantar hyperkeratosis (HP:0007556)3.35237139
21Abnormal hair laboratory examination (HP:0003328)3.31881566
22Woolly hair (HP:0002224)3.31502711
23Nail dystrophy (HP:0008404)3.13979672
24Curly hair (HP:0002212)3.02405680
25Ependymoma (HP:0002888)3.02013816
26Esophageal atresia (HP:0002032)2.92945648
27Selective tooth agenesis (HP:0001592)2.91899050
28Asymmetry of the thorax (HP:0001555)2.87968151
29Abnormal vertebral ossification (HP:0100569)2.85798289
30Biliary tract neoplasm (HP:0100574)2.85252593
31Testicular atrophy (HP:0000029)2.84648011
32Trismus (HP:0000211)2.77604503
33Concave nail (HP:0001598)2.73996282
34Easy fatigability (HP:0003388)2.72631292
35Hypoparathyroidism (HP:0000829)2.71919268
36Abnormality of abdominal situs (HP:0011620)2.69471997
37Abdominal situs inversus (HP:0003363)2.69471997
38Flattened epiphyses (HP:0003071)2.69125273
39Blepharitis (HP:0000498)2.69023677
40Hyperacusis (HP:0010780)2.68956079
41Esophageal varix (HP:0002040)2.60623943
42Rectal prolapse (HP:0002035)2.56563903
43Stenosis of the external auditory canal (HP:0000402)2.55559743
44Malnutrition (HP:0004395)2.54346982
45Cerebral palsy (HP:0100021)2.53608264
46Ankyloglossia (HP:0010296)2.52576624
47Germ cell neoplasia (HP:0100728)2.50451982
48Hyperparathyroidism (HP:0000843)2.44485111
49Gastrointestinal carcinoma (HP:0002672)2.44443336
50Malignant gastrointestinal tract tumors (HP:0006749)2.44443336
51Aortic regurgitation (HP:0001659)2.43285276
52Abnormality of the salivary glands (HP:0010286)2.41678346
53Down-sloping shoulders (HP:0200021)2.41318608
54Morphological abnormality of the inner ear (HP:0011390)2.39088122
55Hypotrichosis (HP:0001006)2.38816071
56Biconcave vertebral bodies (HP:0004586)2.38244762
57Tracheal stenosis (HP:0002777)2.37219491
58Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.36638545
59Bell-shaped thorax (HP:0001591)2.36402458
60Hypoplastic labia majora (HP:0000059)2.36258161
61Mildly elevated creatine phosphokinase (HP:0008180)2.35844109
62Advanced eruption of teeth (HP:0006288)2.34298051
63Abnormality of lateral ventricle (HP:0030047)2.33835867
64Shawl scrotum (HP:0000049)2.33348710
65Colon cancer (HP:0003003)2.33277740
66Distal lower limb muscle weakness (HP:0009053)2.32979489
67Fragile skin (HP:0001030)2.27919160
68Delayed CNS myelination (HP:0002188)2.27071707
69Mucopolysacchariduria (HP:0008155)2.26504290
70Urinary glycosaminoglycan excretion (HP:0003541)2.26504290
71Renal tubular acidosis (HP:0001947)2.26092167
72Visceral angiomatosis (HP:0100761)2.25986801
73Abnormality of the sella turcica (HP:0002679)2.25609611
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24083278
75Seborrheic dermatitis (HP:0001051)2.22458362
76Hyperactive renin-angiotensin system (HP:0000841)2.21417931
77Anal stenosis (HP:0002025)2.21120428
78Abdominal distention (HP:0003270)2.21036431
79Urethral obstruction (HP:0000796)2.20290337
80Short humerus (HP:0005792)2.16288831
81Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.14899851
82Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.14873876
83Growth hormone excess (HP:0000845)2.14597649
84Abnormality of the labia majora (HP:0012881)2.13040980
85Hemorrhage of the eye (HP:0011885)2.11888389
86Upper limb amyotrophy (HP:0009129)2.11209636
87Distal upper limb amyotrophy (HP:0007149)2.11209636
88Abnormality of the distal phalanges of the toes (HP:0010182)2.10328957
89Progressive sensorineural hearing impairment (HP:0000408)2.10300166
90Cerebral aneurysm (HP:0004944)2.10270082
91Widely patent fontanelles and sutures (HP:0004492)2.09400050
92Acanthosis nigricans (HP:0000956)2.09283328
93Pseudobulbar signs (HP:0002200)2.08554265
94Hemangiomatosis (HP:0007461)2.08444357
95Bronchomalacia (HP:0002780)2.08377248
96Hyperthyroidism (HP:0000836)2.06999315
97Severe Myopia (HP:0011003)2.06831121
98Bulbar palsy (HP:0001283)2.06323990
99Abnormality of the gastric mucosa (HP:0004295)2.06128934
100Abnormality of the astrocytes (HP:0100707)2.05183601
101Astrocytoma (HP:0009592)2.05183601
102Aplasia/hypoplasia of the humerus (HP:0006507)2.04651438
103Diaphragmatic weakness (HP:0009113)2.04469802
104Short clavicles (HP:0000894)2.03570847
105Abnormality of polysaccharide metabolism (HP:0011012)2.03334650
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03334650
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03334650
108Atelectasis (HP:0100750)2.03278480
109Uterine neoplasm (HP:0010784)2.02518794
110Abnormality of oral frenula (HP:0000190)2.01967235
111Abnormality of the proximal phalanges of the hand (HP:0009834)2.00867902
112Neurodegeneration (HP:0002180)1.99832302
113Aplasia/Hypoplasia of the clavicles (HP:0006710)1.98095318
114Hypophosphatemia (HP:0002148)1.97720548
115Dysostosis multiplex (HP:0000943)1.97227194
116Hypoplasia of dental enamel (HP:0006297)1.97001688
117Skin pits (HP:0100276)1.95568114
118Pterygium (HP:0001059)1.93709749
119Neoplasm of the heart (HP:0100544)1.93564692
120Spastic diplegia (HP:0001264)1.92469163
121Anonychia (HP:0001798)1.92058237
122Aplasia/hypoplasia of the femur (HP:0005613)1.90705338
123Sparse lateral eyebrow (HP:0005338)1.90285583
124Absent eyelashes (HP:0000561)1.88708707
125Flat acetabular roof (HP:0003180)1.88309727
126Abnormal blistering of the skin (HP:0008066)1.88040889
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.87415182
128Flared iliac wings (HP:0002869)1.84973006
129Sparse scalp hair (HP:0002209)1.84748323
130Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.84240075
131Nuclear cataract (HP:0100018)1.82073178
132Spinal cord compression (HP:0002176)1.81628509
133Abnormal biliary tract morphology (HP:0012440)1.80633493
134Broad nasal tip (HP:0000455)1.80475895
135Palmoplantar hyperkeratosis (HP:0000972)1.80471372
136Abnormality of the dental root (HP:0006486)1.79803034
137Taurodontia (HP:0000679)1.79803034
138Abnormality of permanent molar morphology (HP:0011071)1.79803034
139Ureteral stenosis (HP:0000071)1.79125762
140Skin tags (HP:0010609)1.77343618
141Ridged nail (HP:0001807)1.77305442
142Bicornuate uterus (HP:0000813)1.77208660
143Absent radius (HP:0003974)1.76027361
144Preauricular skin tag (HP:0000384)1.75266987
145Hypoplastic scapulae (HP:0000882)1.75195076
146Aplasia/Hypoplasia of the scapulae (HP:0006713)1.75195076
147Testicular neoplasm (HP:0010788)1.75133619
148Renal dysplasia (HP:0000110)1.74736332
149Breast hypoplasia (HP:0003187)1.74723761
150Palmar hyperkeratosis (HP:0010765)1.74286149
151Alopecia of scalp (HP:0002293)1.73619391
152Distal lower limb amyotrophy (HP:0008944)1.72743385
153Absent forearm bone (HP:0003953)1.72417472
154Aplasia involving forearm bones (HP:0009822)1.72417472
155Abnormality of the 2nd finger (HP:0004100)1.72367387
156Synostosis of carpal bones (HP:0005048)1.71522764
157Unilateral renal agenesis (HP:0000122)1.71484533
158Short phalanx of the thumb (HP:0009660)1.71024665
159Congenital glaucoma (HP:0001087)1.70783351
160Aplasia cutis congenita (HP:0001057)1.70768381
161Ovarian neoplasm (HP:0100615)1.70395902
162Gastrointestinal atresia (HP:0002589)1.70102215
163Abnormal ventriculo-arterial connection (HP:0011563)1.69302422
164Transposition of the great arteries (HP:0001669)1.69302422
165Abnormal connection of the cardiac segments (HP:0011545)1.69302422
166Abnormality of the middle phalanges of the toes (HP:0010183)1.68626876
167Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68196587
168Wide cranial sutures (HP:0010537)1.68067915
169Fused cervical vertebrae (HP:0002949)1.67317065
170Glomerulosclerosis (HP:0000096)1.66979898
171Missing ribs (HP:0000921)1.65444203
172Bundle branch block (HP:0011710)1.65068324
173Delayed epiphyseal ossification (HP:0002663)1.64987838
174Abnormality of nail color (HP:0100643)1.64419807
175Abnormality of molar (HP:0011077)1.64286228
176Abnormality of molar morphology (HP:0011070)1.64286228
177Absent toe (HP:0010760)1.62138770
178Abnormality of small intestinal villus morphology (HP:0011472)1.61447147
179Villous atrophy (HP:0011473)1.61447147
180Vertebral clefting (HP:0008428)1.57740602
181Ureteral obstruction (HP:0006000)1.55563049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.30679320
2LATS13.69748543
3RPS6KB23.32447846
4MST43.09079664
5MAP2K22.58493134
6BUB12.42019702
7TNK22.31775511
8SMG12.26362484
9PKN22.21782827
10AKT32.15680407
11EEF2K2.15649058
12MAP3K32.07926599
13SIK11.98491792
14MUSK1.96670850
15RIPK11.95999009
16PAK41.90034593
17IRAK31.87532320
18STK38L1.85935219
19STK101.84281825
20FER1.83757126
21ERN11.82802773
22CDK121.80656457
23MAP3K21.68418427
24FRK1.59373580
25LATS21.58226771
26PRKCI1.57200360
27MAP3K81.54956578
28PTK61.54564854
29MET1.54548596
30BCKDK1.52120140
31MAPKAPK31.49764314
32TAOK21.48047676
33TESK11.46846676
34PTK21.37906882
35DDR21.35245726
36FGFR41.34471003
37MAPK151.33437424
38TAOK11.27876804
39RPS6KA21.25283109
40MST1R1.23267607
41NEK11.18680570
42LRRK21.18518852
43TRIB31.18065998
44MARK21.13070875
45SIK31.10772520
46PRKD31.10563829
47PRKD21.07984019
48NEK61.07001057
49TTK1.06666495
50LMTK21.04695500
51MAP2K31.02320373
52SCYL20.98729906
53MAP2K10.95892401
54STK30.93151613
55FLT30.91818945
56RPS6KL10.91531542
57RPS6KC10.91531542
58TTN0.87126374
59ILK0.86775993
60PDPK10.86483474
61CAMK1D0.81296138
62CHUK0.80437772
63AURKB0.80308632
64MAP3K100.80277910
65MAP2K60.79261053
66CDK70.78823254
67MATK0.77659964
68MAP3K110.77265370
69FGFR10.76512343
70TESK20.76265101
71RPS6KA60.75853039
72BMX0.74922211
73GRK60.73693445
74ERBB20.73327626
75WNK40.70909461
76EPHB20.70776826
77MTOR0.70179112
78TLK10.69255447
79MAP3K60.68527208
80PAK20.68215877
81WEE10.67980994
82NME10.67044379
83EPHB10.66218059
84PDGFRA0.64726350
85NEK20.63951492
86MAP3K70.61829217
87CDC70.61752396
88TBK10.59865418
89STK390.59306448
90IRAK20.59129474
91CDK60.57502297
92PDK20.57253324
93AKT20.53538118
94TSSK60.53512706
95VRK20.51831310
96LIMK10.51133130
97AURKA0.49110318
98PIM20.48333260
99TRPM70.48180253
100CAMK1G0.47462066
101PRKG20.47366882
102CSNK1E0.47122331
103PAK10.46733424
104NME20.43391090
105HIPK20.42973863
106STK380.42888198
107CAMK2G0.42718968
108DYRK1B0.41483152
109ARAF0.41438774
110PRKD10.40129756
111MAPK80.39893969
112MAPKAPK20.39610686
113RET0.39477157
114PDGFRB0.38831394
115CDC42BPA0.38769844
116MAP3K10.38500876
117SIK20.38380751
118PRKAA20.37376170
119IRAK40.37125030
120PDK10.33930067
121PASK0.32942130
122KSR20.32522876
123PLK10.31238246
124NUAK10.30349228
125CHEK10.30067135
126BRAF0.29830563
127PIK3CA0.29458085
128CAMK2B0.28721103
129RPS6KA40.27324558
130PRKAA10.26950952
131PAK30.26910645
132RPS6KA10.26333463
133KDR0.25714499
134ALK0.25394316
135ICK0.24487177
136CDK40.24285116
137STK40.23978352
138MYLK0.23746244
139EIF2AK10.23351568
140MAP3K90.20664399
141ROCK20.20393359
142TAOK30.19600010
143ERBB40.19573043
144TYRO30.18498061

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.29326921
2Hippo signaling pathway_Homo sapiens_hsa043902.71158672
3Other glycan degradation_Homo sapiens_hsa005112.56726866
4Tight junction_Homo sapiens_hsa045302.46372490
5Sulfur metabolism_Homo sapiens_hsa009202.44824877
6Fat digestion and absorption_Homo sapiens_hsa049752.41115999
7Adherens junction_Homo sapiens_hsa045202.36737890
8Hedgehog signaling pathway_Homo sapiens_hsa043402.24891953
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.19142604
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.10656534
11Bladder cancer_Homo sapiens_hsa052192.01875793
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95351548
13Thyroid cancer_Homo sapiens_hsa052161.81917603
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73815727
15Protein digestion and absorption_Homo sapiens_hsa049741.70013764
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.66363363
17Glutathione metabolism_Homo sapiens_hsa004801.60889519
18Galactose metabolism_Homo sapiens_hsa000521.60650304
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60517763
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58278520
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54760687
22ECM-receptor interaction_Homo sapiens_hsa045121.51185805
23Small cell lung cancer_Homo sapiens_hsa052221.50034710
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.49780367
25Notch signaling pathway_Homo sapiens_hsa043301.46901463
26Insulin signaling pathway_Homo sapiens_hsa049101.45380641
27Proteoglycans in cancer_Homo sapiens_hsa052051.44700063
28One carbon pool by folate_Homo sapiens_hsa006701.42965576
29Arginine biosynthesis_Homo sapiens_hsa002201.42944516
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.42308301
31Histidine metabolism_Homo sapiens_hsa003401.41509583
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40859493
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40209809
34Endometrial cancer_Homo sapiens_hsa052131.39224912
35Ribosome_Homo sapiens_hsa030101.32704092
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32676391
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32251425
38Fructose and mannose metabolism_Homo sapiens_hsa000511.31829598
39Insulin resistance_Homo sapiens_hsa049311.30876698
40RNA transport_Homo sapiens_hsa030131.30698647
41Choline metabolism in cancer_Homo sapiens_hsa052311.30242772
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28603030
43Phenylalanine metabolism_Homo sapiens_hsa003601.27388026
44Folate biosynthesis_Homo sapiens_hsa007901.25554113
45TGF-beta signaling pathway_Homo sapiens_hsa043501.23745155
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23677158
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23020647
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23013716
49Mismatch repair_Homo sapiens_hsa034301.20893416
50Estrogen signaling pathway_Homo sapiens_hsa049151.19894809
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.15871762
52Mineral absorption_Homo sapiens_hsa049781.15629057
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11952696
54Bile secretion_Homo sapiens_hsa049761.11894901
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11742554
56MicroRNAs in cancer_Homo sapiens_hsa052061.11384362
57Sulfur relay system_Homo sapiens_hsa041221.11128737
58Spliceosome_Homo sapiens_hsa030401.10522695
59Focal adhesion_Homo sapiens_hsa045101.08834138
60Pancreatic secretion_Homo sapiens_hsa049721.06884214
61Fatty acid biosynthesis_Homo sapiens_hsa000611.06695819
62p53 signaling pathway_Homo sapiens_hsa041151.06584661
63Pathways in cancer_Homo sapiens_hsa052001.04196444
64PPAR signaling pathway_Homo sapiens_hsa033201.03228634
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.02882799
66Wnt signaling pathway_Homo sapiens_hsa043101.02593402
67DNA replication_Homo sapiens_hsa030301.02482920
68Renin-angiotensin system_Homo sapiens_hsa046141.02306899
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02153467
70Sphingolipid metabolism_Homo sapiens_hsa006001.02072518
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.98583196
72Biosynthesis of amino acids_Homo sapiens_hsa012300.98003000
73ABC transporters_Homo sapiens_hsa020100.96479590
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94486941
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93625252
76Starch and sucrose metabolism_Homo sapiens_hsa005000.93061627
77Vitamin B6 metabolism_Homo sapiens_hsa007500.92845246
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91647306
79ErbB signaling pathway_Homo sapiens_hsa040120.90618377
80Melanoma_Homo sapiens_hsa052180.90551713
81Caffeine metabolism_Homo sapiens_hsa002320.88588407
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84941184
83Melanogenesis_Homo sapiens_hsa049160.84726617
84Inositol phosphate metabolism_Homo sapiens_hsa005620.83429373
85Cell cycle_Homo sapiens_hsa041100.82752871
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.82701792
87Colorectal cancer_Homo sapiens_hsa052100.81878493
88Linoleic acid metabolism_Homo sapiens_hsa005910.81661677
89Axon guidance_Homo sapiens_hsa043600.80175833
90Selenocompound metabolism_Homo sapiens_hsa004500.80087882
91Non-small cell lung cancer_Homo sapiens_hsa052230.79640037
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79306288
93Chemical carcinogenesis_Homo sapiens_hsa052040.78705957
94Endocytosis_Homo sapiens_hsa041440.76093943
95Pentose phosphate pathway_Homo sapiens_hsa000300.76007450
96Prostate cancer_Homo sapiens_hsa052150.75795579
97Glucagon signaling pathway_Homo sapiens_hsa049220.75161431
98Collecting duct acid secretion_Homo sapiens_hsa049660.74407534
99Glycerolipid metabolism_Homo sapiens_hsa005610.73902626
100Chronic myeloid leukemia_Homo sapiens_hsa052200.73023473
101Amoebiasis_Homo sapiens_hsa051460.71808609
102GnRH signaling pathway_Homo sapiens_hsa049120.71062856
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.70295688
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69617743
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69614182
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69298288
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68766163
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68191612
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.67517404
110Fatty acid metabolism_Homo sapiens_hsa012120.67398890
111mRNA surveillance pathway_Homo sapiens_hsa030150.65999636
112mTOR signaling pathway_Homo sapiens_hsa041500.65967324
113Tyrosine metabolism_Homo sapiens_hsa003500.64714055
114Vibrio cholerae infection_Homo sapiens_hsa051100.64648191
115Vitamin digestion and absorption_Homo sapiens_hsa049770.64547149
116Hepatitis C_Homo sapiens_hsa051600.63823150
117HTLV-I infection_Homo sapiens_hsa051660.62920700
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62645443
119Arginine and proline metabolism_Homo sapiens_hsa003300.61494847
120N-Glycan biosynthesis_Homo sapiens_hsa005100.60389559
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60234669
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.60068261
123Thyroid hormone synthesis_Homo sapiens_hsa049180.58912732
124Viral carcinogenesis_Homo sapiens_hsa052030.57030734
125Lysosome_Homo sapiens_hsa041420.56737489
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55248062
127Renal cell carcinoma_Homo sapiens_hsa052110.53888423
128Pyruvate metabolism_Homo sapiens_hsa006200.53118240
129Base excision repair_Homo sapiens_hsa034100.51981710
130Carbon metabolism_Homo sapiens_hsa012000.51660058
131Acute myeloid leukemia_Homo sapiens_hsa052210.50289823
132Rap1 signaling pathway_Homo sapiens_hsa040150.48623548
133Pancreatic cancer_Homo sapiens_hsa052120.48221149
134Prolactin signaling pathway_Homo sapiens_hsa049170.48128558
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47751364
136Lysine degradation_Homo sapiens_hsa003100.44992525
137Ovarian steroidogenesis_Homo sapiens_hsa049130.44420133
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43988121
139Toxoplasmosis_Homo sapiens_hsa051450.42951170
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.42335196
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40759637
142Gastric acid secretion_Homo sapiens_hsa049710.39181090
143Arachidonic acid metabolism_Homo sapiens_hsa005900.38143317
144VEGF signaling pathway_Homo sapiens_hsa043700.36001681
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35351703
146AMPK signaling pathway_Homo sapiens_hsa041520.34449900
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33773074

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