RBBP8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.43235926
2microglial cell activation (GO:0001774)5.88330444
3regulation of B cell receptor signaling pathway (GO:0050855)5.72844631
4detection of molecule of bacterial origin (GO:0032490)5.47403897
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.46232325
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.46232325
7modulation by symbiont of host immune response (GO:0052553)5.46232325
8positive regulation by symbiont of host defense response (GO:0052509)5.46232325
9modulation by symbiont of host defense response (GO:0052031)5.46232325
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.46232325
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.95848515
12negative regulation of cell killing (GO:0031342)4.95848515
13hepatocyte apoptotic process (GO:0097284)4.93548521
14regulation of gamma-delta T cell differentiation (GO:0045586)4.89141050
15macrophage activation involved in immune response (GO:0002281)4.80025290
16regulation of gamma-delta T cell activation (GO:0046643)4.79646681
17macrophage activation (GO:0042116)4.55720820
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.53578487
19cellular extravasation (GO:0045123)4.43902055
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.41227628
21histone H3-K36 demethylation (GO:0070544)4.27479724
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.24003024
23B cell receptor signaling pathway (GO:0050853)4.21712219
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14513906
25regulation of interferon-beta biosynthetic process (GO:0045357)4.00737125
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.94575819
27response to interleukin-15 (GO:0070672)3.88925039
28negative T cell selection (GO:0043383)3.88329041
29positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.87016173
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86400918
31response to host immune response (GO:0052572)3.86400918
32negative thymic T cell selection (GO:0045060)3.85169111
33positive T cell selection (GO:0043368)3.84226926
34negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.83322760
35detection of external biotic stimulus (GO:0098581)3.80350397
36negative regulation of B cell proliferation (GO:0030889)3.70871586
37positive regulation of granulocyte differentiation (GO:0030854)3.68554075
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.67365453
39interferon-gamma production (GO:0032609)3.67316223
40cellular response to interleukin-15 (GO:0071350)3.66405123
41neutrophil mediated immunity (GO:0002446)3.62843324
42negative regulation of T cell mediated immunity (GO:0002710)3.62408686
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62250846
44response to host (GO:0075136)3.62250846
45response to host defenses (GO:0052200)3.62250846
46histone mRNA catabolic process (GO:0071044)3.61136856
47negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.58284057
48myeloid leukocyte mediated immunity (GO:0002444)3.57246684
49activated T cell proliferation (GO:0050798)3.53485327
50positive thymic T cell selection (GO:0045059)3.52800434
51protein K11-linked deubiquitination (GO:0035871)3.51773202
52establishment of protein localization to Golgi (GO:0072600)3.48705942
53monoubiquitinated protein deubiquitination (GO:0035520)3.45111699
54positive regulation of B cell differentiation (GO:0045579)3.42330047
55neutrophil activation involved in immune response (GO:0002283)3.38520925
56cellular response to ethanol (GO:0071361)3.37119550
57myeloid cell activation involved in immune response (GO:0002275)3.35721341
58regulation of B cell differentiation (GO:0045577)3.33825712
59protein targeting to Golgi (GO:0000042)3.33463642
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.33383117
61detection of biotic stimulus (GO:0009595)3.28035330
62detection of other organism (GO:0098543)3.27559474
63negative regulation of interleukin-12 production (GO:0032695)3.18709301
64retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15348776
65regulation of necroptotic process (GO:0060544)3.11825475
66T cell migration (GO:0072678)3.07857553
67positive regulation of interferon-alpha production (GO:0032727)3.04848214
68respiratory burst (GO:0045730)3.04223711
69protein K48-linked deubiquitination (GO:0071108)3.02051792
70negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01088210
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96515317
72regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94687635
73positive regulation of mast cell activation (GO:0033005)2.94622939
74regulation of interleukin-6 biosynthetic process (GO:0045408)2.93254352
75T cell selection (GO:0045058)2.93158753
76regulation of beta-amyloid formation (GO:1902003)2.92797447
77dosage compensation (GO:0007549)2.90591216
78regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.87452462
79regulation of platelet aggregation (GO:0090330)2.83250059
80leukocyte aggregation (GO:0070486)2.82090631
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.80855981
82negative regulation of B cell mediated immunity (GO:0002713)2.80550157
83negative regulation of immunoglobulin mediated immune response (GO:0002890)2.80550157
84histone H3-K4 trimethylation (GO:0080182)2.80336815
85production of molecular mediator involved in inflammatory response (GO:0002532)2.80202418
86negative regulation of leukocyte mediated immunity (GO:0002704)2.79873184
87T cell proliferation (GO:0042098)2.78471084
88regulation of interferon-alpha production (GO:0032647)2.78274073
89negative regulation of adaptive immune response (GO:0002820)2.76716726
90regulation of granulocyte differentiation (GO:0030852)2.76173466
91regulation of mast cell activation (GO:0033003)2.75573546
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74397332
93neutrophil activation (GO:0042119)2.71930471
94regulation of B cell proliferation (GO:0030888)2.70048049
95regulation of interleukin-12 biosynthetic process (GO:0045075)2.66902098
96T-helper 1 type immune response (GO:0042088)2.65699817
97response to peptidoglycan (GO:0032494)2.65197576
98defense response to protozoan (GO:0042832)2.64925311
99regulation of mast cell degranulation (GO:0043304)2.64256501
100regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63833950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.79431116
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.73057852
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.22497111
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.43310033
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.37540192
6GATA1_22025678_ChIP-Seq_K562_Human3.29447776
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.18253149
8RUNX_20019798_ChIP-Seq_JUKART_Human3.12799153
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.10021034
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04060073
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92525305
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.77906222
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75957017
14SCL_19346495_ChIP-Seq_HPC-7_Human2.74751388
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73291513
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.52283904
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.50107954
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44057091
19MYB_26560356_Chip-Seq_TH2_Human2.38003863
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37121144
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12772715
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92798091
23SPI1_23127762_ChIP-Seq_K562_Human1.87071939
24GATA3_27048872_Chip-Seq_THYMUS_Human1.87014609
25MYB_26560356_Chip-Seq_TH1_Human1.86926751
26VDR_24787735_ChIP-Seq_THP-1_Human1.80917822
27SPI1_23547873_ChIP-Seq_NB4_Human1.80657371
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80165972
29TP53_16413492_ChIP-PET_HCT116_Human1.73901699
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66023750
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64459807
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59778292
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57151648
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55995547
35GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53252180
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48909247
37PU_27001747_Chip-Seq_BMDM_Mouse1.47466525
38GATA1_19941826_ChIP-Seq_K562_Human1.45801920
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.40407934
40GATA3_26560356_Chip-Seq_TH2_Human1.39702856
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.38000502
42VDR_24763502_ChIP-Seq_THP-1_Human1.35378745
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32923817
44MAF_26560356_Chip-Seq_TH1_Human1.32577934
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32035799
46GATA2_19941826_ChIP-Seq_K562_Human1.30953956
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27895634
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27576416
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26363720
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26132738
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.25757462
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23249002
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.20514024
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18491589
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18482785
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18417893
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.10560981
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.10056861
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09708895
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08814310
61AR_21572438_ChIP-Seq_LNCaP_Human1.08526314
62GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07391916
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.03907537
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.03354714
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00005111
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99492020
67PRDM14_20953172_ChIP-Seq_ESCs_Human0.99210736
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98435199
69SMRT_27268052_Chip-Seq_Bcells_Human0.98326950
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95848845
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95052745
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95052745
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93295176
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92070857
75UTX_26944678_Chip-Seq_JUKART_Human0.91962233
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90804393
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89286213
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88884812
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87825107
80SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87225796
81ER_23166858_ChIP-Seq_MCF-7_Human0.87019343
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86816403
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86629788
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.86430465
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.86380529
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86378673
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85100652
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.84592451
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84142130
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83406006
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82551479
92TCF7_22412390_ChIP-Seq_EML_Mouse0.82236102
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.82175881
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82118640
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81373176
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80499240
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79445034
98AHR_22903824_ChIP-Seq_MCF-7_Human0.78707109
99GATA3_26560356_Chip-Seq_TH1_Human0.77216295
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76808680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.85449879
2MP0003724_increased_susceptibility_to3.90505437
3MP0008260_abnormal_autophagy3.55736280
4MP0001835_abnormal_antigen_presentation3.29318024
5MP0008057_abnormal_DNA_replication3.01018101
6MP0003183_abnormal_peptide_metabolism2.92158820
7MP0003763_abnormal_thymus_physiology2.91498852
8MP0003656_abnormal_erythrocyte_physiolo2.81741492
9MP0003303_peritoneal_inflammation2.65050397
10MP0001800_abnormal_humoral_immune2.60845731
11MP0003787_abnormal_imprinting2.33390987
12MP0002166_altered_tumor_susceptibility2.33389621
13MP0005451_abnormal_body_composition2.18211614
14MP0002419_abnormal_innate_immunity2.17823971
15MP0004381_abnormal_hair_follicle2.16794786
16MP0005464_abnormal_platelet_physiology2.14991972
17MP0004883_abnormal_blood_vessel2.14074029
18MP0003436_decreased_susceptibility_to2.12805573
19MP0002723_abnormal_immune_serum2.12321723
20MP0005671_abnormal_response_to2.09739371
21MP0002452_abnormal_antigen_presenting2.04643867
22MP0003172_abnormal_lysosome_physiology2.04446071
23MP0002396_abnormal_hematopoietic_system2.04216598
24MP0002420_abnormal_adaptive_immunity2.02903900
25MP0001819_abnormal_immune_cell2.01301380
26MP0005000_abnormal_immune_tolerance1.94834099
27MP0000015_abnormal_ear_pigmentation1.92945421
28MP0000685_abnormal_immune_system1.89230450
29MP0002398_abnormal_bone_marrow1.87161878
30MP0005025_abnormal_response_to1.82024515
31MP0005310_abnormal_salivary_gland1.80557845
32MP0005174_abnormal_tail_pigmentation1.78468140
33MP0003828_pulmonary_edema1.76104914
34MP0005075_abnormal_melanosome_morpholog1.74532120
35MP0000716_abnormal_immune_system1.71526595
36MP0002332_abnormal_exercise_endurance1.67902999
37MP0003300_gastrointestinal_ulcer1.67852535
38MP0002009_preneoplasia1.67288667
39MP0003221_abnormal_cardiomyocyte_apopto1.66857332
40MP0002405_respiratory_system_inflammati1.66418523
41MP0003690_abnormal_glial_cell1.62614558
42MP0005387_immune_system_phenotype1.60698356
43MP0001790_abnormal_immune_system1.60698356
44MP0002722_abnormal_immune_system1.59135425
45MP0000689_abnormal_spleen_morphology1.58826359
46MP0009785_altered_susceptibility_to1.55058731
47MP0002006_tumorigenesis1.54282364
48MP0006082_CNS_inflammation1.51943383
49MP0008877_abnormal_DNA_methylation1.51354431
50MP0000703_abnormal_thymus_morphology1.51105565
51MP0005164_abnormal_response_to1.41253072
52MP0004484_altered_response_of1.35258865
53MP0001851_eye_inflammation1.33982751
54MP0002429_abnormal_blood_cell1.32817446
55MP0003866_abnormal_defecation1.29729975
56MP0004808_abnormal_hematopoietic_stem1.26548668
57MP0001845_abnormal_inflammatory_respons1.24634274
58MP0002163_abnormal_gland_morphology1.17054207
59MP0001545_abnormal_hematopoietic_system1.12578775
60MP0005397_hematopoietic_system_phenotyp1.12578775
61MP0002998_abnormal_bone_remodeling1.10697116
62MP0009764_decreased_sensitivity_to1.10616210
63MP0004130_abnormal_muscle_cell1.09380111
64MP0002148_abnormal_hypersensitivity_rea1.07287911
65MP0000604_amyloidosis1.05131346
66MP0004947_skin_inflammation1.03660470
67MP0000858_altered_metastatic_potential1.02924098
68MP0000371_diluted_coat_color0.98940478
69MP0001853_heart_inflammation0.98480776
70MP0001533_abnormal_skeleton_physiology0.97553735
71MP0005076_abnormal_cell_differentiation0.95922487
72MP0003091_abnormal_cell_migration0.94314353
73MP0005376_homeostasis/metabolism_phenot0.92184735
74MP0002132_abnormal_respiratory_system0.91411405
75MP0010155_abnormal_intestine_physiology0.90601177
76MP0000465_gastrointestinal_hemorrhage0.86925911
77MP0003191_abnormal_cellular_cholesterol0.81822954
78MP0006054_spinal_hemorrhage0.81033180
79MP0008469_abnormal_protein_level0.80941303
80MP0009333_abnormal_splenocyte_physiolog0.77876759
81MP0009115_abnormal_fat_cell0.77589930
82MP0005266_abnormal_metabolism0.77153060
83MP0003121_genomic_imprinting0.74385265
84MP0003329_amyloid_beta_deposits0.74379513
85MP0000249_abnormal_blood_vessel0.74050423
86MP0003632_abnormal_nervous_system0.71253403
87MP0003045_fibrosis0.69301947
88MP0009278_abnormal_bone_marrow0.69259522
89MP0002019_abnormal_tumor_incidence0.65825855
90MP0005408_hypopigmentation0.65789177
91MP0001915_intracranial_hemorrhage0.64910523
92MP0002277_abnormal_respiratory_mucosa0.64876807
93MP0003195_calcinosis0.64765815
94MP0005379_endocrine/exocrine_gland_phen0.64531274
95MP0002928_abnormal_bile_duct0.63571420
96MP0003448_altered_tumor_morphology0.62970370
97MP0005388_respiratory_system_phenotype0.61836292
98MP0002133_abnormal_respiratory_system0.61836292
99MP0005621_abnormal_cell_physiology0.61150653
100MP0000427_abnormal_hair_cycle0.60569505

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.67433114
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.55008567
3Recurrent bacterial skin infections (HP:0005406)5.50714037
4Abnormality of T cell number (HP:0011839)5.16169103
5Recurrent abscess formation (HP:0002722)4.66400165
6Retrobulbar optic neuritis (HP:0100654)4.15890596
7Optic neuritis (HP:0100653)4.15890596
8Spontaneous hematomas (HP:0007420)3.95822752
9Orchitis (HP:0100796)3.95192659
10Eczematoid dermatitis (HP:0000976)3.94656853
11Myositis (HP:0100614)3.83361935
12Recurrent fungal infections (HP:0002841)3.79183664
13Slow saccadic eye movements (HP:0000514)3.68738216
14Gastrointestinal infarctions (HP:0005244)3.66777435
15Recurrent skin infections (HP:0001581)3.51748183
16Gingival bleeding (HP:0000225)3.40105377
17Recurrent cutaneous fungal infections (HP:0011370)3.32346355
18Chronic mucocutaneous candidiasis (HP:0002728)3.32346355
19Recurrent bronchitis (HP:0002837)3.30523580
20Abnormality of T cells (HP:0002843)3.28332307
21Arterial thrombosis (HP:0004420)3.10080103
22Gingivitis (HP:0000230)3.01833765
23Keratoconjunctivitis sicca (HP:0001097)2.99544418
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.98656593
25Recurrent viral infections (HP:0004429)2.98081757
26Mediastinal lymphadenopathy (HP:0100721)2.81325295
27Recurrent gram-negative bacterial infections (HP:0005420)2.81106728
28Genetic anticipation (HP:0003743)2.79287594
29Encephalitis (HP:0002383)2.78747368
30Thoracolumbar scoliosis (HP:0002944)2.78326174
31Subacute progressive viral hepatitis (HP:0006572)2.77455887
32Leukocytosis (HP:0001974)2.76180005
33Keratoconjunctivitis (HP:0001096)2.73773128
34Peritonitis (HP:0002586)2.70738339
35Chest pain (HP:0100749)2.69751580
36Postural instability (HP:0002172)2.69715623
37Elevated erythrocyte sedimentation rate (HP:0003565)2.69056071
38Stomatitis (HP:0010280)2.67700132
39Conjunctival telangiectasia (HP:0000524)2.67253897
40Broad ribs (HP:0000885)2.67131417
41Abnormality of the vasculature of the conjunctiva (HP:0008054)2.58439454
42Meningitis (HP:0001287)2.54860603
43Papillary thyroid carcinoma (HP:0002895)2.54434889
44Abnormality of the fingertips (HP:0001211)2.53864673
45Vasculitis (HP:0002633)2.52779389
46Diastasis recti (HP:0001540)2.49047392
47Epistaxis (HP:0000421)2.43025970
48Hemoptysis (HP:0002105)2.40469837
49Eosinophilia (HP:0001880)2.37069131
50Abnormality of eosinophils (HP:0001879)2.35725726
51Subaortic stenosis (HP:0001682)2.26702255
52Abnormality of the left ventricular outflow tract (HP:0011103)2.26702255
53Vertebral arch anomaly (HP:0008438)2.25945262
54Prolonged bleeding time (HP:0003010)2.25541560
55Viral hepatitis (HP:0006562)2.25299965
56Visual hallucinations (HP:0002367)2.24704612
57Abnormality of macrophages (HP:0004311)2.23735277
58Periodontitis (HP:0000704)2.23107580
59Anorexia (HP:0002039)2.20188908
60Thyroiditis (HP:0100646)2.20021959
61Amaurosis fugax (HP:0100576)2.17149553
62Neoplasm of the tracheobronchial system (HP:0100552)2.14535111
63Poikilocytosis (HP:0004447)2.13983237
64Pulmonary embolism (HP:0002204)2.10599109
65Autoimmune hemolytic anemia (HP:0001890)2.09062149
66Hypoplasia of the thymus (HP:0000778)2.08306508
67IgA deficiency (HP:0002720)2.07636247
68Bladder carcinoma (HP:0002862)2.04818922
69Bladder neoplasm (HP:0009725)2.04818922
70Obstructive lung disease (HP:0006536)2.04481818
71Chronic obstructive pulmonary disease (HP:0006510)2.04481818
72Resting tremor (HP:0002322)2.00859130
73Pustule (HP:0200039)2.00790220
74Inflammation of the large intestine (HP:0002037)2.00776386
75Carpal bone hypoplasia (HP:0001498)2.00573426
76Microcytic anemia (HP:0001935)1.99300673
77Hemiplegia (HP:0002301)1.99131188
78Granulocytopenia (HP:0001913)1.98624249
79Pulmonary infiltrates (HP:0002113)1.95682299
80Gangrene (HP:0100758)1.89476291
81Autoimmune thrombocytopenia (HP:0001973)1.89196881
82Acute myeloid leukemia (HP:0004808)1.89183838
83Prominent nose (HP:0000448)1.87241961
84Abnormality of T cell physiology (HP:0011840)1.87024632
85Urticaria (HP:0001025)1.86981899
86IgG deficiency (HP:0004315)1.86724207
87Abnormality of the columella (HP:0009929)1.86534442
88Acute hepatic failure (HP:0006554)1.85989552
89Abnormality of liposaccharide metabolism (HP:0010968)1.83440458
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.83440458
91Abnormality of glycolipid metabolism (HP:0010969)1.83440458
92Orthostatic hypotension (HP:0001278)1.83023118
93Colitis (HP:0002583)1.79967547
94Chronic diarrhea (HP:0002028)1.79517757
95Transitional cell carcinoma of the bladder (HP:0006740)1.79418421
96Abnormality of the sella turcica (HP:0002679)1.78162340
97Hematochezia (HP:0002573)1.78016337
98Dislocated radial head (HP:0003083)1.78003906
99Abnormality of the peritoneum (HP:0002585)1.77891567
100Narrow palate (HP:0000189)1.77752159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.68111849
2BLK3.29377669
3FRK2.69739193
4MAP4K12.59384794
5TGFBR22.56701575
6TXK2.50315094
7MAP2K32.44287813
8GRK62.19735539
9MAP3K22.19102058
10GRK52.15298802
11ACVR1B2.09682656
12PIK3CG2.03848172
13BMPR22.02478134
14IRAK41.96134987
15TAOK31.95480996
16FGR1.95157064
17IKBKE1.90731401
18JAK31.88732093
19GRK71.88526068
20CSK1.84987630
21MAP3K61.78856995
22IRAK11.77271758
23SYK1.71257551
24AKT31.64461427
25IRAK21.60781165
26TYK21.51194333
27ZAP701.48294445
28STK101.48174590
29JAK11.39740710
30SGK21.39271596
31WNK11.39177600
32FGFR31.38614772
33TEC1.37650587
34FES1.37574382
35BTK1.34786210
36PTK2B1.29946898
37STK41.29892951
38MOS1.29639868
39JAK21.23230415
40MAP3K141.17151459
41HCK1.15161220
42CAMKK21.13136520
43ITK1.12182258
44PIM11.11337196
45MARK31.07761522
46YES11.01273138
47SGK31.01236622
48MAP2K41.00358120
49LYN0.99879219
50MAP3K10.99237114
51CDK120.99232209
52PKN20.95334951
53MARK20.94946103
54MELK0.94517854
55PDK10.93332874
56NLK0.91587549
57MAP3K50.90759840
58PLK20.89189884
59RET0.88930087
60PRPF4B0.88838424
61CSF1R0.88034934
62LCK0.87718941
63KSR10.86514249
64MATK0.85262784
65LRRK20.77690552
66CAMK40.76838753
67DYRK1A0.75587507
68ERBB20.74438301
69KSR20.74386657
70RAF10.72394164
71CAMK1G0.71697612
72CAMK1D0.71049655
73STK110.69421256
74MAP3K130.68691759
75ADRBK10.68343415
76SGK2230.65838931
77SGK4940.65838931
78EPHA30.62645881
79TRPM70.61515136
80SGK10.60778211
81MAP2K60.58731396
82MAP3K110.57144406
83STK380.54760423
84STK160.54752522
85PRKCQ0.54197869
86EPHB10.53167517
87TNK20.52154653
88MAP3K70.51238861
89IKBKB0.47443506
90KIT0.46633034
91CDK60.44828825
92EGFR0.43185451
93HIPK20.40636999
94TAOK10.40454282
95NEK60.40185552
96FGFR40.35795725
97MAPKAPK20.35474448
98CHUK0.35398913
99NTRK30.35179957
100NUAK10.34010508

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.48914848
2Leishmaniasis_Homo sapiens_hsa051402.45886761
3Osteoclast differentiation_Homo sapiens_hsa043802.33640057
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.30900271
5T cell receptor signaling pathway_Homo sapiens_hsa046601.97345320
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.96688387
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96497437
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92213521
9Non-small cell lung cancer_Homo sapiens_hsa052231.90322384
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87198175
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.77143242
12Staphylococcus aureus infection_Homo sapiens_hsa051501.73207215
13Tuberculosis_Homo sapiens_hsa051521.71232662
14Measles_Homo sapiens_hsa051621.59355943
15Dorso-ventral axis formation_Homo sapiens_hsa043201.59139083
16Acute myeloid leukemia_Homo sapiens_hsa052211.58350058
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55745753
18Graft-versus-host disease_Homo sapiens_hsa053321.55202058
19Primary immunodeficiency_Homo sapiens_hsa053401.55188705
20Platelet activation_Homo sapiens_hsa046111.54935386
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47111802
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.45370384
23FoxO signaling pathway_Homo sapiens_hsa040681.44140118
24Hepatitis B_Homo sapiens_hsa051611.38199979
25Malaria_Homo sapiens_hsa051441.36861082
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36580849
27Pancreatic cancer_Homo sapiens_hsa052121.36549191
28Chemokine signaling pathway_Homo sapiens_hsa040621.36034036
29Toxoplasmosis_Homo sapiens_hsa051451.34061364
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30682808
31TNF signaling pathway_Homo sapiens_hsa046681.28896680
32Prolactin signaling pathway_Homo sapiens_hsa049171.27118289
33Influenza A_Homo sapiens_hsa051641.26484009
34Hematopoietic cell lineage_Homo sapiens_hsa046401.26423042
35Chronic myeloid leukemia_Homo sapiens_hsa052201.25620281
36Legionellosis_Homo sapiens_hsa051341.24886290
37Inositol phosphate metabolism_Homo sapiens_hsa005621.22874141
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21598141
39Renal cell carcinoma_Homo sapiens_hsa052111.20529809
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18354907
41Endometrial cancer_Homo sapiens_hsa052131.15956108
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12437954
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.07378487
44mTOR signaling pathway_Homo sapiens_hsa041501.05884423
45VEGF signaling pathway_Homo sapiens_hsa043701.04632736
46Antigen processing and presentation_Homo sapiens_hsa046121.01905113
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01461514
48Hepatitis C_Homo sapiens_hsa051600.99799205
49Viral carcinogenesis_Homo sapiens_hsa052030.99443978
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.95312287
51Apoptosis_Homo sapiens_hsa042100.94860605
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93511542
53Prostate cancer_Homo sapiens_hsa052150.93139586
54GnRH signaling pathway_Homo sapiens_hsa049120.91798647
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90599504
56Colorectal cancer_Homo sapiens_hsa052100.89534447
57ErbB signaling pathway_Homo sapiens_hsa040120.89196224
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.88488484
59Glioma_Homo sapiens_hsa052140.88074715
60Allograft rejection_Homo sapiens_hsa053300.86363968
61HIF-1 signaling pathway_Homo sapiens_hsa040660.85880193
62Systemic lupus erythematosus_Homo sapiens_hsa053220.84823196
63Autoimmune thyroid disease_Homo sapiens_hsa053200.84644681
64Long-term potentiation_Homo sapiens_hsa047200.81803716
65African trypanosomiasis_Homo sapiens_hsa051430.78364805
66Notch signaling pathway_Homo sapiens_hsa043300.78061770
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77609790
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76901082
69Choline metabolism in cancer_Homo sapiens_hsa052310.76428042
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75159844
71Type II diabetes mellitus_Homo sapiens_hsa049300.73320718
72Herpes simplex infection_Homo sapiens_hsa051680.70514257
73Cholinergic synapse_Homo sapiens_hsa047250.69719247
74Insulin resistance_Homo sapiens_hsa049310.69465234
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68898087
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.68625946
77Renin secretion_Homo sapiens_hsa049240.66480737
78MAPK signaling pathway_Homo sapiens_hsa040100.65992244
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65947378
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.64624440
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.64378572
82Estrogen signaling pathway_Homo sapiens_hsa049150.61309050
83Phagosome_Homo sapiens_hsa041450.59801893
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59299458
85HTLV-I infection_Homo sapiens_hsa051660.58426645
86Small cell lung cancer_Homo sapiens_hsa052220.58228643
87MicroRNAs in cancer_Homo sapiens_hsa052060.57323187
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55803364
89Amoebiasis_Homo sapiens_hsa051460.52858926
90Long-term depression_Homo sapiens_hsa047300.50681869
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50164163
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49191684
93Pertussis_Homo sapiens_hsa051330.49103927
94Rap1 signaling pathway_Homo sapiens_hsa040150.49014317
95Thyroid cancer_Homo sapiens_hsa052160.46401815
96Oxytocin signaling pathway_Homo sapiens_hsa049210.46236897
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44442524
98Type I diabetes mellitus_Homo sapiens_hsa049400.42067908
99Asthma_Homo sapiens_hsa053100.41927705
100Viral myocarditis_Homo sapiens_hsa054160.41392331

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