RBCK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.66644366
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.66644366
3positive regulation of gamma-delta T cell activation (GO:0046645)5.93847461
4antigen processing and presentation of endogenous antigen (GO:0019883)5.85419423
5regulation of gamma-delta T cell differentiation (GO:0045586)5.41922994
6antigen processing and presentation via MHC class Ib (GO:0002475)4.81622604
7regulation of gamma-delta T cell activation (GO:0046643)4.80019039
8positive thymic T cell selection (GO:0045059)4.79869695
9negative regulation of cell killing (GO:0031342)4.55659362
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55659362
11ribosomal small subunit assembly (GO:0000028)4.51568429
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.49790978
13negative thymic T cell selection (GO:0045060)4.30809478
14negative T cell selection (GO:0043383)4.27953158
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.02036020
16DNA deamination (GO:0045006)3.97301327
17thymic T cell selection (GO:0045061)3.95752990
18viral transcription (GO:0019083)3.94355835
19DNA unwinding involved in DNA replication (GO:0006268)3.69968287
20translational termination (GO:0006415)3.68966237
21positive T cell selection (GO:0043368)3.61548094
22response to interleukin-15 (GO:0070672)3.60423268
23positive regulation of lamellipodium assembly (GO:0010592)3.60154929
24Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53951749
25negative regulation of erythrocyte differentiation (GO:0045647)3.51485597
26translational elongation (GO:0006414)3.48954440
27regulation of B cell receptor signaling pathway (GO:0050855)3.48536229
28detection of bacterium (GO:0016045)3.46959244
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44918065
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.44918065
31modulation by symbiont of host immune response (GO:0052553)3.44918065
32positive regulation by symbiont of host defense response (GO:0052509)3.44918065
33modulation by symbiont of host defense response (GO:0052031)3.44918065
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44918065
35positive regulation of B cell differentiation (GO:0045579)3.42893684
36regulation of B cell differentiation (GO:0045577)3.41782882
37T cell selection (GO:0045058)3.40697631
38B cell receptor signaling pathway (GO:0050853)3.39866086
39T cell migration (GO:0072678)3.37875647
40detection of other organism (GO:0098543)3.34933252
41response to peptidoglycan (GO:0032494)3.32433342
42natural killer cell differentiation (GO:0001779)3.24337655
43regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23159761
44negative regulation of phagocytosis (GO:0050765)3.22726857
45leukocyte aggregation (GO:0070486)3.20664079
46DNA strand elongation involved in DNA replication (GO:0006271)3.19856288
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18434040
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16466800
49mannose metabolic process (GO:0006013)3.14914775
50positive regulation of lamellipodium organization (GO:1902745)3.11037332
51positive regulation of histone deacetylation (GO:0031065)3.06809313
52COPI coating of Golgi vesicle (GO:0048205)3.03637773
53Golgi transport vesicle coating (GO:0048200)3.03637773
54macrophage activation involved in immune response (GO:0002281)3.02215886
55DNA strand elongation (GO:0022616)3.01892451
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01376712
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.00039060
58cellular response to interleukin-4 (GO:0071353)2.97530854
59positive regulation of Cdc42 GTPase activity (GO:0043089)2.97318699
60telomere maintenance via semi-conservative replication (GO:0032201)2.96890144
61regulation of extracellular matrix disassembly (GO:0010715)2.96479164
62positive regulation of isotype switching (GO:0045830)2.95605842
63pinocytosis (GO:0006907)2.95124310
64regulation of interleukin-12 biosynthetic process (GO:0045075)2.94363596
65response to muramyl dipeptide (GO:0032495)2.93784270
66regulation of response to interferon-gamma (GO:0060330)2.92213362
67negative regulation of RNA splicing (GO:0033119)2.92133281
68maturation of SSU-rRNA (GO:0030490)2.90869492
69regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.90159249
70pentose-phosphate shunt (GO:0006098)2.89998390
71translational initiation (GO:0006413)2.89541330
72cellular response to interleukin-15 (GO:0071350)2.89507898
73viral life cycle (GO:0019058)2.88613123
74T cell apoptotic process (GO:0070231)2.88198583
75protein targeting to ER (GO:0045047)2.88036070
76detection of external biotic stimulus (GO:0098581)2.87735050
77protein localization to endosome (GO:0036010)2.85541217
78cellular response to virus (GO:0098586)2.84450774
79cotranslational protein targeting to membrane (GO:0006613)2.84071494
80Peyers patch development (GO:0048541)2.82322747
81mucosal-associated lymphoid tissue development (GO:0048537)2.82322747
82folic acid-containing compound biosynthetic process (GO:0009396)2.81587738
83regulation of isotype switching to IgG isotypes (GO:0048302)2.78855959
84* antigen receptor-mediated signaling pathway (GO:0050851)2.77223478
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77174335
86neutrophil activation involved in immune response (GO:0002283)2.76656043
87cellular protein complex disassembly (GO:0043624)2.76469562
88regulation of interferon-beta biosynthetic process (GO:0045357)2.75352243
89positive regulation of extracellular matrix organization (GO:1903055)2.73777204
90negative regulation of viral release from host cell (GO:1902187)2.73544929
91* T cell receptor signaling pathway (GO:0050852)2.73482641
92positive regulation of protein deacetylation (GO:0090312)2.72186805
93establishment of protein localization to endoplasmic reticulum (GO:0072599)2.72134218
94regulation of superoxide anion generation (GO:0032928)2.71396524
95JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70664773
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70404792
97T cell costimulation (GO:0031295)2.69633062
98dosage compensation (GO:0007549)2.69068837
99NIK/NF-kappaB signaling (GO:0038061)2.68978020
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68560428
101T cell homeostasis (GO:0043029)2.68414391
102protein complex disassembly (GO:0043241)2.67523018
103response to type I interferon (GO:0034340)2.66971752
104protein localization to endoplasmic reticulum (GO:0070972)2.66328060
105lymphocyte costimulation (GO:0031294)2.66017631
106response to interleukin-4 (GO:0070670)2.65334526
1073-UTR-mediated mRNA stabilization (GO:0070935)2.64871272
108modulation by symbiont of host cellular process (GO:0044068)2.64420486
109cellular response to type I interferon (GO:0071357)2.63312562
110type I interferon signaling pathway (GO:0060337)2.63312562
111formation of translation preinitiation complex (GO:0001731)2.62037465
112barbed-end actin filament capping (GO:0051016)2.58509163
113regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57229361
114ribosomal small subunit biogenesis (GO:0042274)2.56446659
115B cell mediated immunity (GO:0019724)2.56403706
116ncRNA 3-end processing (GO:0043628)2.56217852
117germinal center formation (GO:0002467)2.54797132
118negative regulation of cytokine production involved in immune response (GO:0002719)2.54307186
119cellular response to zinc ion (GO:0071294)2.53975030
120IMP biosynthetic process (GO:0006188)2.53799559
121regulation of translational fidelity (GO:0006450)2.53671793
122detection of biotic stimulus (GO:0009595)2.53417352
123interferon-gamma-mediated signaling pathway (GO:0060333)2.52891685
124regulation of extracellular matrix organization (GO:1903053)2.52126797
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50809349
126immunoglobulin mediated immune response (GO:0016064)2.50753785
127glucose 6-phosphate metabolic process (GO:0051156)2.50093596
128lymphocyte apoptotic process (GO:0070227)2.49846972
129response to host (GO:0075136)2.49575297
130response to host defenses (GO:0052200)2.49575297
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49575297
132leukocyte cell-cell adhesion (GO:0007159)2.49076778
133protein retention in ER lumen (GO:0006621)2.48661380
134regulation of T cell receptor signaling pathway (GO:0050856)2.47404405
135macromolecular complex disassembly (GO:0032984)2.47061722
136maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46651859
137mast cell activation (GO:0045576)2.46356534
138regulation of protein heterodimerization activity (GO:0043497)2.45686632
139DNA replication initiation (GO:0006270)2.45546940
140response to laminar fluid shear stress (GO:0034616)2.44613031
141modulation by virus of host process (GO:0019054)2.44540237
142detection of molecule of bacterial origin (GO:0032490)2.44155447
143regulation of T-helper 2 cell differentiation (GO:0045628)2.43881137
144myeloid dendritic cell differentiation (GO:0043011)2.41708646
145regulation of cholesterol homeostasis (GO:2000188)2.40595470
146regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40587211
147negative regulation of fibrinolysis (GO:0051918)2.39593158
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39187857
149negative regulation of innate immune response (GO:0045824)2.37622737
150protein carboxylation (GO:0018214)2.35026185
151peptidyl-glutamic acid carboxylation (GO:0017187)2.35026185
152regulation of plasminogen activation (GO:0010755)2.32814923
153regulation of leukocyte degranulation (GO:0043300)2.32341646
154response to host immune response (GO:0052572)2.31409628
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.31409628
156negative regulation of myeloid cell apoptotic process (GO:0033033)2.30023323
157regulation of viral release from host cell (GO:1902186)2.28989374
158apoptotic process involved in morphogenesis (GO:0060561)2.27195212
159negative regulation of fatty acid biosynthetic process (GO:0045717)2.26875455
160signal complex assembly (GO:0007172)2.25457936
161activation of Rac GTPase activity (GO:0032863)2.25383088
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25010959
163regulation of mast cell degranulation (GO:0043304)2.24759691
164positive regulation of type 2 immune response (GO:0002830)2.24046110
165GDP-mannose metabolic process (GO:0019673)2.23127308
166response to interferon-alpha (GO:0035455)2.23018510
167positive regulation of interferon-alpha production (GO:0032727)2.22617625
168positive regulation of fatty acid biosynthetic process (GO:0045723)2.21817654
169positive regulation of lipoprotein lipase activity (GO:0051006)2.21742140
170positive regulation of triglyceride lipase activity (GO:0061365)2.21742140
171negative regulation of digestive system process (GO:0060457)2.21162279
172stress fiber assembly (GO:0043149)2.21107359
173negative regulation of interleukin-12 production (GO:0032695)2.19762664
174protein-lipid complex assembly (GO:0065005)2.19754182
175desmosome organization (GO:0002934)2.18701129
176retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.18064128
177negative regulation of cell size (GO:0045792)2.17195697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.27869813
2MYC_22102868_ChIP-Seq_BL_Human3.69944352
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.69456226
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41600285
5VDR_21846776_ChIP-Seq_THP-1_Human2.84805517
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56175631
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.50291490
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.38707621
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34789700
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.28099639
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.23869088
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21992352
13MAF_26560356_Chip-Seq_TH1_Human2.15559069
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11102857
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10900553
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04280075
17UTX_26944678_Chip-Seq_JUKART_Human2.02091558
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98869691
19TCF7_22412390_ChIP-Seq_EML_Mouse1.98362995
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97692312
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97035845
22CIITA_25753668_ChIP-Seq_RAJI_Human1.95703854
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95196493
24SCL_19346495_ChIP-Seq_HPC-7_Human1.91958058
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86694381
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81031767
27* MYB_26560356_Chip-Seq_TH2_Human1.77972438
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77243922
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76361067
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74100373
31* RXR_22158963_ChIP-Seq_LIVER_Mouse1.70955069
32VDR_24763502_ChIP-Seq_THP-1_Human1.68453464
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68130813
34* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67987121
35MYB_26560356_Chip-Seq_TH1_Human1.66947801
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.65937117
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65802799
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63239419
39KDM2B_26808549_Chip-Seq_DND41_Human1.63122343
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61938307
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61462686
42LXR_22292898_ChIP-Seq_THP-1_Human1.60115772
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60066171
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.59661316
45* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59615813
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59580856
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.59484642
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59242701
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58727371
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.57011911
51XRN2_22483619_ChIP-Seq_HELA_Human1.55547441
52MAF_26560356_Chip-Seq_TH2_Human1.54093119
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52908751
54SPI1_23547873_ChIP-Seq_NB4_Human1.50837467
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50226462
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48274997
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45685030
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44950649
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44242695
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42835285
61* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42693204
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42255688
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41657829
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.41349057
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40665024
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.40092650
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40022478
68KDM2B_26808549_Chip-Seq_K562_Human1.39409288
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38311723
70* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37873279
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.36667201
72* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35208691
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32462559
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.30259440
75ATF3_27146783_Chip-Seq_COLON_Human1.29322745
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28133964
77RUNX_20019798_ChIP-Seq_JUKART_Human1.26806139
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25861569
79FOXP3_21729870_ChIP-Seq_TREG_Human1.24144518
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23709572
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.23170830
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23126301
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23047029
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22987803
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22773496
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21831615
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21584240
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20604284
89SMC4_20622854_ChIP-Seq_HELA_Human1.20445595
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.20044151
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19470761
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18084607
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17978215
94* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17706238
95SPI1_23127762_ChIP-Seq_K562_Human1.17316331
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16482875
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16479924
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16186765
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15358629
100VDR_23849224_ChIP-Seq_CD4+_Human1.15287780
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14299725
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14260073
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.14227444
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13031035
105* BCL6_27268052_Chip-Seq_Bcells_Human1.11880482
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10854554
107* GABP_19822575_ChIP-Seq_HepG2_Human1.10308034
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10209320
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09914462
110CREB1_26743006_Chip-Seq_LNCaP_Human1.09718401
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09292792
112CLOCK_20551151_ChIP-Seq_293T_Human1.09005495
113P68_20966046_ChIP-Seq_HELA_Human1.08641487
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08509206
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08138695
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.08110798
117* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07869890
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07022085
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.06938911
120TP53_22127205_ChIP-Seq_IMR90_Human1.06848264
121* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06718290
122ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06449481
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06343348
124KDM5A_27292631_Chip-Seq_BREAST_Human1.05701650
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05323011
126E2F1_21310950_ChIP-Seq_MCF-7_Human1.05218286
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04688085
128NCOR1_26117541_ChIP-Seq_K562_Human1.04604328
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03355803
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02757764
131RACK7_27058665_Chip-Seq_MCF-7_Human1.02512619
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02196812
133NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01860853
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01785017
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01260800
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99543291
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98723429
138EST1_17652178_ChIP-ChIP_JURKAT_Human0.96655848
139* BCOR_27268052_Chip-Seq_Bcells_Human0.96562297
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95256843
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94014493
142GATA1_22025678_ChIP-Seq_K562_Human0.93668335
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92778108
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92586317
145ZNF263_19887448_ChIP-Seq_K562_Human0.92171210
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92011762
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91864814
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.91731596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.52032129
2MP0000685_abnormal_immune_system3.47757150
3MP0002396_abnormal_hematopoietic_system3.44950600
4MP0001835_abnormal_antigen_presentation3.12990173
5MP0005451_abnormal_body_composition2.82071267
6MP0005671_abnormal_response_to2.79537400
7MP0005058_abnormal_lysosome_morphology2.79144371
8MP0001800_abnormal_humoral_immune2.64406511
9MP0002398_abnormal_bone_marrow2.53332955
10MP0002166_altered_tumor_susceptibility2.42605449
11MP0010352_gastrointestinal_tract_polyps2.34060538
12MP0009785_altered_susceptibility_to2.31322484
13MP0005387_immune_system_phenotype2.28703551
14MP0001790_abnormal_immune_system2.28703551
15MP0001873_stomach_inflammation2.24056239
16MP0002420_abnormal_adaptive_immunity2.23733006
17MP0001819_abnormal_immune_cell2.20252343
18MP0002723_abnormal_immune_serum2.18651801
19MP0003300_gastrointestinal_ulcer2.17142780
20MP0002722_abnormal_immune_system2.16885158
21MP0002452_abnormal_antigen_presenting2.15602167
22MP0005000_abnormal_immune_tolerance2.14764160
23MP0000689_abnormal_spleen_morphology2.12529524
24MP0003436_decreased_susceptibility_to2.12113651
25MP0005025_abnormal_response_to2.11690240
26MP0000716_abnormal_immune_system2.10273493
27MP0008260_abnormal_autophagy2.08959245
28MP0005397_hematopoietic_system_phenotyp2.08008982
29MP0001545_abnormal_hematopoietic_system2.08008982
30MP0000703_abnormal_thymus_morphology2.07545787
31MP0005464_abnormal_platelet_physiology2.05853301
32MP0003866_abnormal_defecation2.05823150
33MP0010155_abnormal_intestine_physiology1.99919255
34MP0002405_respiratory_system_inflammati1.96830262
35MP0009333_abnormal_splenocyte_physiolog1.95508325
36MP0003693_abnormal_embryo_hatching1.95283311
37MP0002139_abnormal_hepatobiliary_system1.93228924
38MP0002429_abnormal_blood_cell1.91649190
39MP0004808_abnormal_hematopoietic_stem1.88596011
40MP0004947_skin_inflammation1.86424645
41MP0002006_tumorigenesis1.79041513
42MP0000490_abnormal_crypts_of1.74594694
43MP0003303_peritoneal_inflammation1.71605104
44MP0001853_heart_inflammation1.69293411
45MP0003111_abnormal_nucleus_morphology1.66627574
46MP0009278_abnormal_bone_marrow1.64952506
47MP0010094_abnormal_chromosome_stability1.59519132
48MP0004858_abnormal_nervous_system1.52955782
49MP0008438_abnormal_cutaneous_collagen1.51850072
50MP0002419_abnormal_innate_immunity1.50795320
51MP0003077_abnormal_cell_cycle1.49666869
52MP0001845_abnormal_inflammatory_respons1.45889291
53MP0004957_abnormal_blastocyst_morpholog1.44449654
54MP0002019_abnormal_tumor_incidence1.41136980
55MP0006082_CNS_inflammation1.40773992
56MP0000465_gastrointestinal_hemorrhage1.40456025
57MP0003075_altered_response_to1.36900165
58MP0008961_abnormal_basal_metabolism1.35942416
59MP0009840_abnormal_foam_cell1.33960036
60MP0000678_abnormal_parathyroid_gland1.33894669
61MP0003724_increased_susceptibility_to1.31465304
62MP0003191_abnormal_cellular_cholesterol1.30511417
63MP0000858_altered_metastatic_potential1.27920192
64MP0003705_abnormal_hypodermis_morpholog1.26891450
65MP0004185_abnormal_adipocyte_glucose1.25232747
66MP0002148_abnormal_hypersensitivity_rea1.23909958
67MP0004510_myositis1.23225203
68MP0003183_abnormal_peptide_metabolism1.21881879
69MP0002998_abnormal_bone_remodeling1.21181960
70MP0003091_abnormal_cell_migration1.18944588
71MP0002933_joint_inflammation1.18814108
72MP0008469_abnormal_protein_level1.15570110
73MP0005409_darkened_coat_color1.15315776
74MP0003329_amyloid_beta_deposits1.12550697
75MP0005365_abnormal_bile_salt1.12453928
76MP0003172_abnormal_lysosome_physiology1.12263370
77MP0004381_abnormal_hair_follicle1.10480491
78MP0005666_abnormal_adipose_tissue1.10208279
79MP0006054_spinal_hemorrhage1.10103985
80MP0005083_abnormal_biliary_tract1.08816752
81MP0000604_amyloidosis1.08061355
82MP0005164_abnormal_response_to1.07502749
83MP0005310_abnormal_salivary_gland1.07161195
84MP0010307_abnormal_tumor_latency1.05928994
85MP0005075_abnormal_melanosome_morpholog1.04797561
86MP0005174_abnormal_tail_pigmentation1.04761197
87MP0001958_emphysema1.03297423
88MP0002138_abnormal_hepatobiliary_system1.03040264
89MP0005023_abnormal_wound_healing1.01864922
90MP0001730_embryonic_growth_arrest1.01425237
91MP0003806_abnormal_nucleotide_metabolis1.00919970
92MP0008057_abnormal_DNA_replication1.00622832
93MP0004264_abnormal_extraembryonic_tissu0.98630902
94MP0005076_abnormal_cell_differentiation0.98509856
95MP0008004_abnormal_stomach_pH0.98333303
96MP0005670_abnormal_white_adipose0.96126958
97MP0003279_aneurysm0.96083915
98MP0001851_eye_inflammation0.95579021
99MP0000609_abnormal_liver_physiology0.95166759
100MP0010234_abnormal_vibrissa_follicle0.94435992
101MP0005390_skeleton_phenotype0.94309469
102MP0003656_abnormal_erythrocyte_physiolo0.92944872
103MP0000313_abnormal_cell_death0.92334190
104MP0002060_abnormal_skin_morphology0.90481178
105MP0003566_abnormal_cell_adhesion0.90432243
106MP0000477_abnormal_intestine_morphology0.89948485
107MP0001348_abnormal_lacrimal_gland0.89844998
108MP0005375_adipose_tissue_phenotype0.89163440
109MP0008007_abnormal_cellular_replicative0.89077531
110MP0005165_increased_susceptibility_to0.89037294
111MP0002796_impaired_skin_barrier0.87932506
112MP0005381_digestive/alimentary_phenotyp0.87351438
113MP0000350_abnormal_cell_proliferation0.87125721
114MP0001533_abnormal_skeleton_physiology0.87040032
115MP0009764_decreased_sensitivity_to0.86750597
116MP0004883_abnormal_blood_vessel0.83074282
117MP0000343_altered_response_to0.82892155
118MP0000003_abnormal_adipose_tissue0.82569491
119MP0002132_abnormal_respiratory_system0.81357636
120MP0000598_abnormal_liver_morphology0.80977440
121MP0008058_abnormal_DNA_repair0.78818340
122MP0000371_diluted_coat_color0.77973356
123MP0002089_abnormal_postnatal_growth/wei0.75714481
124MP0009763_increased_sensitivity_to0.75297784
125MP0003448_altered_tumor_morphology0.75251425
126MP0002080_prenatal_lethality0.72947065
127MP0009643_abnormal_urine_homeostasis0.65966453
128MP0005166_decreased_susceptibility_to0.65558633
129MP0003453_abnormal_keratinocyte_physiol0.64163956
130MP0001663_abnormal_digestive_system0.63144808
131MP0002136_abnormal_kidney_physiology0.62571459
132MP0002909_abnormal_adrenal_gland0.61746041
133MP0002086_abnormal_extraembryonic_tissu0.61243269
134MP0002970_abnormal_white_adipose0.61220167
135MP0005319_abnormal_enzyme/_coenzyme0.60441810
136MP0002095_abnormal_skin_pigmentation0.59911438
137MP0002877_abnormal_melanocyte_morpholog0.58551472
138MP0005360_urolithiasis0.58549341
139MP0001849_ear_inflammation0.58086483

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.61823472
2IgM deficiency (HP:0002850)4.30890473
3Recurrent bronchitis (HP:0002837)4.06034437
4Nasal polyposis (HP:0100582)4.02131391
5Elevated erythrocyte sedimentation rate (HP:0003565)3.96533884
6Deep venous thrombosis (HP:0002625)3.92314556
7T lymphocytopenia (HP:0005403)3.89098759
8Abnormality of the nasal mucosa (HP:0000433)3.84849392
9Abnormality of T cells (HP:0002843)3.80650011
10Abnormality of T cell number (HP:0011839)3.69392080
11Thrombocytosis (HP:0001894)3.52495272
12Abnormality of T cell physiology (HP:0011840)3.43995197
13Recurrent viral infections (HP:0004429)3.43966327
14Panhypogammaglobulinemia (HP:0003139)3.24772382
15Recurrent fungal infections (HP:0002841)3.15172228
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.06837772
17Abnormality of cells of the erythroid lineage (HP:0012130)3.06513659
18Gastrointestinal inflammation (HP:0004386)3.05443303
19Pustule (HP:0200039)3.04545013
20Hemorrhage of the eye (HP:0011885)3.03486517
21Combined immunodeficiency (HP:0005387)3.02448351
22Severe combined immunodeficiency (HP:0004430)2.99810249
23Orchitis (HP:0100796)2.98977828
24Systemic lupus erythematosus (HP:0002725)2.98042087
25Abnormality of macrophages (HP:0004311)2.97141257
26Abnormal number of erythroid precursors (HP:0012131)2.92526519
27Protrusio acetabuli (HP:0003179)2.91627774
28Cellulitis (HP:0100658)2.86038830
29Hyperacusis (HP:0010780)2.84770998
30Inflammation of the large intestine (HP:0002037)2.83296286
31Myositis (HP:0100614)2.83268149
32Basal cell carcinoma (HP:0002671)2.77999567
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.77379904
34Verrucae (HP:0200043)2.76496018
35Papilloma (HP:0012740)2.76496018
36Eczematoid dermatitis (HP:0000976)2.75896331
37Autoimmune thrombocytopenia (HP:0001973)2.75545214
38Lymphopenia (HP:0001888)2.75516562
39Prolonged bleeding time (HP:0003010)2.68579092
40Increased IgE level (HP:0003212)2.67220074
41Abnormality of the fingertips (HP:0001211)2.60382928
42Petechiae (HP:0000967)2.58216208
43Vertebral compression fractures (HP:0002953)2.58055752
44Dysostosis multiplex (HP:0000943)2.57916239
45IgG deficiency (HP:0004315)2.56825307
46Amyloidosis (HP:0011034)2.53824114
47Agammaglobulinemia (HP:0004432)2.53668713
48Abnormality of B cell number (HP:0010975)2.53639129
49B lymphocytopenia (HP:0010976)2.53639129
50Spontaneous hematomas (HP:0007420)2.52924575
51Purpura (HP:0000979)2.52773221
52Recurrent gram-negative bacterial infections (HP:0005420)2.52769339
53Joint hemorrhage (HP:0005261)2.47955474
54Reticulocytopenia (HP:0001896)2.47811605
55Broad face (HP:0000283)2.42467382
56Abnormality of complement system (HP:0005339)2.41876412
57Colitis (HP:0002583)2.41278004
58Thin bony cortex (HP:0002753)2.39285404
59Gastrointestinal infarctions (HP:0005244)2.37839702
60IgA deficiency (HP:0002720)2.36889867
61Poikiloderma (HP:0001029)2.34255273
62Thyroiditis (HP:0100646)2.34059958
63Retrobulbar optic neuritis (HP:0100654)2.33630267
64Optic neuritis (HP:0100653)2.33630267
65Mucopolysacchariduria (HP:0008155)2.33623923
66Urinary glycosaminoglycan excretion (HP:0003541)2.33623923
67Recurrent cutaneous fungal infections (HP:0011370)2.33417534
68Chronic mucocutaneous candidiasis (HP:0002728)2.33417534
69Abnormal platelet function (HP:0011869)2.32693817
70Impaired platelet aggregation (HP:0003540)2.32693817
71Epistaxis (HP:0000421)2.32617089
72Peritonitis (HP:0002586)2.32407070
73Polygenic inheritance (HP:0010982)2.31075032
74Meningitis (HP:0001287)2.29684456
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29476793
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29476793
77Abnormality of polysaccharide metabolism (HP:0011012)2.29476793
78Recurrent abscess formation (HP:0002722)2.29175814
79Gingivitis (HP:0000230)2.28270044
80Cervical subluxation (HP:0003308)2.27955021
81Loss of speech (HP:0002371)2.25741274
82Bronchitis (HP:0012387)2.23639088
83Emphysema (HP:0002097)2.23331364
84Chronic obstructive pulmonary disease (HP:0006510)2.18992240
85Obstructive lung disease (HP:0006536)2.18992240
86Lymphoma (HP:0002665)2.18356281
87Interstitial pulmonary disease (HP:0006530)2.14713348
88Complement deficiency (HP:0004431)2.13545253
89Menorrhagia (HP:0000132)2.12156375
90Hypoplasia of the thymus (HP:0000778)2.10780863
91Flat acetabular roof (HP:0003180)2.05505813
92Axonal loss (HP:0003447)2.04329147
93Multiple enchondromatosis (HP:0005701)2.04113266
94Malnutrition (HP:0004395)2.04002710
95Hypergammaglobulinemia (HP:0010702)2.02041456
96Atrophic scars (HP:0001075)2.01851374
97Aplastic anemia (HP:0001915)2.00408606
98Short nail (HP:0001799)2.00138992
99Gastrointestinal stroma tumor (HP:0100723)1.98582186
100Increased density of long bones (HP:0006392)1.98109604
101Recurrent bacterial skin infections (HP:0005406)1.97940669
102Urticaria (HP:0001025)1.97560446
103Elfin facies (HP:0004428)1.97388605
104Stomatitis (HP:0010280)1.97173487
105Vasculitis (HP:0002633)1.97025170
106Distal lower limb amyotrophy (HP:0008944)1.96433485
107Abnormality of the thoracic spine (HP:0100711)1.96105541
108Neurofibrillary tangles (HP:0002185)1.95933081
109Distal upper limb amyotrophy (HP:0007149)1.95931440
110Upper limb amyotrophy (HP:0009129)1.95931440
111Abnormal platelet volume (HP:0011876)1.95271720
112Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94762280
113Hypertriglyceridemia (HP:0002155)1.91612646
114Chest pain (HP:0100749)1.91087865
115Glomerulonephritis (HP:0000099)1.90733499
116Leukocytosis (HP:0001974)1.90160012
117Abnormality of carpal bone ossification (HP:0006257)1.89255753
118Abnormality of liposaccharide metabolism (HP:0010968)1.88967388
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.88967388
120Abnormality of glycolipid metabolism (HP:0010969)1.88967388
121Chronic sinusitis (HP:0011109)1.88697079
122Chronic diarrhea (HP:0002028)1.88279293
123Fragile skin (HP:0001030)1.87649282
124Increased cerebral lipofuscin (HP:0011813)1.86994041
125Prominent nose (HP:0000448)1.85520561
126Albinism (HP:0001022)1.85421978
127Autoimmune hemolytic anemia (HP:0001890)1.85399392
128Ependymoma (HP:0002888)1.84531180
129Thoracic kyphosis (HP:0002942)1.84506314
130Colon cancer (HP:0003003)1.83880039
131Premature rupture of membranes (HP:0001788)1.83580391
132Recurrent skin infections (HP:0001581)1.83522575
133Mediastinal lymphadenopathy (HP:0100721)1.83312901
134Xanthomatosis (HP:0000991)1.82840342
135Cholecystitis (HP:0001082)1.82178459
136Abnormal gallbladder physiology (HP:0012438)1.82178459
137Joint swelling (HP:0001386)1.81251814
138Pallor (HP:0000980)1.80474521
139Abnormality of the Achilles tendon (HP:0005109)1.79917167
140Aneurysm (HP:0002617)1.79907305
141Hematochezia (HP:0002573)1.79310187
142Increased connective tissue (HP:0009025)1.79190246
143Granulocytopenia (HP:0001913)1.78519643
144Abnormality of eosinophils (HP:0001879)1.78050792
145Cerebral inclusion bodies (HP:0100314)1.77948835
146Hypertensive crisis (HP:0100735)1.77918582
147Increased IgM level (HP:0003496)1.77594720
148Nuclear cataract (HP:0100018)1.77354590
149Radial bowing (HP:0002986)1.76691279
150Easy fatigability (HP:0003388)1.75873559
151Pulmonary embolism (HP:0002204)1.74851617
152Oral leukoplakia (HP:0002745)1.74766704
153Biconcave vertebral bodies (HP:0004586)1.73578804
154Obstructive sleep apnea (HP:0002870)1.73522336
155Cerebral aneurysm (HP:0004944)1.73485740
156Pulmonary infiltrates (HP:0002113)1.73264793
157Increased serum ferritin (HP:0003281)1.72106674
158Skin ulcer (HP:0200042)1.72041141
159Polycythemia (HP:0001901)1.71903497
160Prolonged neonatal jaundice (HP:0006579)1.71693614
161Acute lymphatic leukemia (HP:0006721)1.71652708
162Disproportionate tall stature (HP:0001519)1.71263899
163Microcytic anemia (HP:0001935)1.70840633
164Arterial thrombosis (HP:0004420)1.70807505
165Gingival bleeding (HP:0000225)1.70667907
166Recurrent sinusitis (HP:0011108)1.70516197
167Abnormal ossification of hand bones (HP:0005921)1.70485077
168Selective tooth agenesis (HP:0001592)1.70078320
169Myocardial infarction (HP:0001658)1.69995032
170Abnormality of reticulocytes (HP:0004312)1.69919629
171Hemoptysis (HP:0002105)1.68208880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.64124991
2EEF2K3.54787853
3TRIB33.38812543
4PKN23.13785444
5PRPF4B3.05252895
6MAP3K102.89980838
7ERN12.58253331
8IRAK32.49807665
9SMG12.27455128
10ZAP702.15799559
11MST1R2.15278136
12EPHA22.06841501
13TYK22.06276057
14SCYL22.05234099
15JAK32.04838557
16FLT31.90164538
17GRK61.87175480
18RIPK41.85797388
19BTK1.83989842
20LRRK21.82390640
21MAP3K31.79893169
22KDR1.78612118
23STK101.78514688
24FGFR41.75202203
25TESK21.66552122
26TBK11.62918411
27EPHB11.60656118
28KIT1.54691999
29TAOK21.50417542
30TXK1.50318355
31ITK1.50276363
32BLK1.48058815
33IKBKE1.41772486
34NME21.38564932
35TGFBR11.37706846
36LMTK21.33954782
37MAP3K111.31886056
38NEK21.30255507
39SYK1.29148377
40JAK11.28231160
41CDC42BPA1.25189901
42PRKD21.24708231
43SIK21.19279847
44RIPK11.19002120
45MAP2K31.18520902
46RPS6KA41.17234650
47CSF1R1.16574393
48MARK21.14985613
49PASK1.12179082
50PTK61.07361163
51MAP3K11.06353653
52TEC1.05044353
53CDK41.04838820
54CDC71.03342441
55HCK1.02908016
56RPS6KB21.01147553
57SIK10.98536687
58DDR20.98492978
59ARAF0.97885032
60LCK0.97513770
61TGFBR20.95736895
62EIF2AK10.94339591
63CSK0.93286393
64PDPK10.91927650
65TAOK10.90321777
66FGR0.89131000
67CDK120.87214409
68MAP3K80.84064565
69MAPKAPK30.83227232
70PAK40.82806202
71PTK20.81279192
72MAP3K70.81077561
73IRAK20.78571708
74BUB10.78556057
75PIM20.78128424
76TTN0.77383868
77MATK0.76756087
78PIM10.76345247
79JAK20.76294200
80ACVR1B0.75090955
81IRAK40.72627006
82FGFR30.72177493
83ATR0.71608427
84PRKD30.71354972
85CDK70.71237673
86BMX0.71056715
87FES0.71038124
88IKBKB0.68899514
89MAPK110.68812863
90ALK0.68620661
91MET0.68267562
92LYN0.67959426
93RPS6KA20.67773534
94MAP3K130.65956080
95BCKDK0.65480459
96ICK0.65024950
97MAP3K60.64667557
98KSR20.62447910
99TAOK30.61214941
100CLK10.60757438
101NLK0.60326581
102WEE10.59833263
103DYRK1B0.56261131
104RPS6KC10.55632757
105RPS6KL10.55632757
106TNK20.55309887
107TESK10.52497135
108CDK60.51238741
109HIPK20.50694684
110SIK30.50663973
111MAP2K60.50135893
112DAPK10.48844938
113PRKG20.48624287
114EIF2AK30.48167760
115ILK0.47002423
116MAPK120.45309433
117CHUK0.45161715
118PRKCH0.45035266
119TYRO30.43844397
120STK380.43731600
121MAP3K140.43381501
122STK40.43272752
123AURKB0.42731619
124CDK80.42551857
125MARK30.42233168
126MAPK70.41264322
127CAMKK10.41102255
128DYRK30.40120444
129NTRK10.37295269
130MTOR0.36937911
131RET0.36597101
132EPHB20.36161005
133RAF10.35970710
134NEK10.29809184
135TSSK60.29366105
136RPS6KA60.28368219
137PDGFRA0.27526574
138PDK10.27006271
139MAPKAPK20.26503026

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.31557971
2DNA replication_Homo sapiens_hsa030303.54319223
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.57094035
4Ribosome_Homo sapiens_hsa030102.43751576
5Mismatch repair_Homo sapiens_hsa034302.42452935
6B cell receptor signaling pathway_Homo sapiens_hsa046622.31541677
7Base excision repair_Homo sapiens_hsa034102.28791770
8T cell receptor signaling pathway_Homo sapiens_hsa046601.98242464
9Antigen processing and presentation_Homo sapiens_hsa046121.97431354
10Measles_Homo sapiens_hsa051621.93288331
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.93204419
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89817619
13Acute myeloid leukemia_Homo sapiens_hsa052211.73275844
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.73267731
15Leishmaniasis_Homo sapiens_hsa051401.70353727
16Spliceosome_Homo sapiens_hsa030401.69362267
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.60561412
18Complement and coagulation cascades_Homo sapiens_hsa046101.53798395
19Herpes simplex infection_Homo sapiens_hsa051681.52890390
20Fructose and mannose metabolism_Homo sapiens_hsa000511.50888274
21Hematopoietic cell lineage_Homo sapiens_hsa046401.46073007
22Graft-versus-host disease_Homo sapiens_hsa053321.45794125
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44518822
24Autoimmune thyroid disease_Homo sapiens_hsa053201.44107058
25Chronic myeloid leukemia_Homo sapiens_hsa052201.43299082
26Osteoclast differentiation_Homo sapiens_hsa043801.43188660
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40580860
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35658618
29One carbon pool by folate_Homo sapiens_hsa006701.35545845
30Malaria_Homo sapiens_hsa051441.24544581
31Sulfur relay system_Homo sapiens_hsa041221.23941624
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21482148
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19974040
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.18735661
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17967989
36Viral myocarditis_Homo sapiens_hsa054161.17796025
37Apoptosis_Homo sapiens_hsa042101.17565475
38Prion diseases_Homo sapiens_hsa050201.17127940
39Shigellosis_Homo sapiens_hsa051311.12623219
40Bladder cancer_Homo sapiens_hsa052191.10056310
41HTLV-I infection_Homo sapiens_hsa051661.08706595
42Pentose phosphate pathway_Homo sapiens_hsa000301.08681817
43Hepatitis B_Homo sapiens_hsa051611.08230253
44Lysosome_Homo sapiens_hsa041421.07658614
45RNA transport_Homo sapiens_hsa030131.06692410
46Toxoplasmosis_Homo sapiens_hsa051451.06642640
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.05890683
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01018576
49VEGF signaling pathway_Homo sapiens_hsa043701.00897615
50Type I diabetes mellitus_Homo sapiens_hsa049401.00873050
51Homologous recombination_Homo sapiens_hsa034401.00769557
52Non-small cell lung cancer_Homo sapiens_hsa052231.00760239
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.98727242
54Influenza A_Homo sapiens_hsa051640.96900756
55African trypanosomiasis_Homo sapiens_hsa051430.96302404
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96117176
57Nucleotide excision repair_Homo sapiens_hsa034200.95657315
58Pyrimidine metabolism_Homo sapiens_hsa002400.95254970
59Cell cycle_Homo sapiens_hsa041100.93925380
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93802788
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92992342
62Viral carcinogenesis_Homo sapiens_hsa052030.92674083
63Caffeine metabolism_Homo sapiens_hsa002320.92304025
64Biosynthesis of amino acids_Homo sapiens_hsa012300.91997110
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91209441
66Epstein-Barr virus infection_Homo sapiens_hsa051690.90484520
67Legionellosis_Homo sapiens_hsa051340.90361518
68p53 signaling pathway_Homo sapiens_hsa041150.90243274
69Thyroid cancer_Homo sapiens_hsa052160.88987301
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88566328
71Salmonella infection_Homo sapiens_hsa051320.87193045
72Endocytosis_Homo sapiens_hsa041440.86789309
73Pancreatic cancer_Homo sapiens_hsa052120.86133266
74Non-homologous end-joining_Homo sapiens_hsa034500.86068748
75Allograft rejection_Homo sapiens_hsa053300.84959840
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.84927221
77Notch signaling pathway_Homo sapiens_hsa043300.84447068
78Amoebiasis_Homo sapiens_hsa051460.82469855
79Asthma_Homo sapiens_hsa053100.80629461
80Platelet activation_Homo sapiens_hsa046110.80302840
81Colorectal cancer_Homo sapiens_hsa052100.80021838
82Selenocompound metabolism_Homo sapiens_hsa004500.79817731
83N-Glycan biosynthesis_Homo sapiens_hsa005100.78423378
84Chemokine signaling pathway_Homo sapiens_hsa040620.77877838
85Small cell lung cancer_Homo sapiens_hsa052220.76490860
86Insulin signaling pathway_Homo sapiens_hsa049100.75345348
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75296332
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74853117
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74244794
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.72975007
91Renal cell carcinoma_Homo sapiens_hsa052110.70267465
92Phagosome_Homo sapiens_hsa041450.69713659
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69015413
94Insulin resistance_Homo sapiens_hsa049310.67055554
95Lysine degradation_Homo sapiens_hsa003100.66743746
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.65932948
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65384922
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.65249296
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.64731324
100Arginine biosynthesis_Homo sapiens_hsa002200.64368208
101RNA degradation_Homo sapiens_hsa030180.63730780
102TNF signaling pathway_Homo sapiens_hsa046680.63524106
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62533247
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61485317
105Phenylalanine metabolism_Homo sapiens_hsa003600.61433621
106Prolactin signaling pathway_Homo sapiens_hsa049170.60912281
107mTOR signaling pathway_Homo sapiens_hsa041500.60740208
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60724806
109PPAR signaling pathway_Homo sapiens_hsa033200.56466677
110Staphylococcus aureus infection_Homo sapiens_hsa051500.56446025
111Vibrio cholerae infection_Homo sapiens_hsa051100.55873641
112Focal adhesion_Homo sapiens_hsa045100.55754405
113Carbon metabolism_Homo sapiens_hsa012000.54777050
114ErbB signaling pathway_Homo sapiens_hsa040120.54491896
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53893022
116GnRH signaling pathway_Homo sapiens_hsa049120.53703478
117Tuberculosis_Homo sapiens_hsa051520.52948173
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52134571
119Proteoglycans in cancer_Homo sapiens_hsa052050.51740076
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.51393410
121Other glycan degradation_Homo sapiens_hsa005110.51172806
122Choline metabolism in cancer_Homo sapiens_hsa052310.51064478
123mRNA surveillance pathway_Homo sapiens_hsa030150.50291122
124HIF-1 signaling pathway_Homo sapiens_hsa040660.50064057
125Systemic lupus erythematosus_Homo sapiens_hsa053220.49907335
126Hepatitis C_Homo sapiens_hsa051600.49851418
127Galactose metabolism_Homo sapiens_hsa000520.49597561
128Pertussis_Homo sapiens_hsa051330.49447720
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47254418
130Endometrial cancer_Homo sapiens_hsa052130.46823721
131Proteasome_Homo sapiens_hsa030500.43369891
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43251743
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.42634931
134ABC transporters_Homo sapiens_hsa020100.37980536
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37560823

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