RBFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.83008505
2ribosomal small subunit assembly (GO:0000028)5.42719898
3viral transcription (GO:0019083)4.86842898
4translational termination (GO:0006415)4.70500609
5DNA damage response, detection of DNA damage (GO:0042769)4.62654693
6maturation of SSU-rRNA (GO:0030490)4.40596956
7translational elongation (GO:0006414)4.38154068
8regulation of mitochondrial translation (GO:0070129)4.26329444
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24153085
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.24153085
11NADH dehydrogenase complex assembly (GO:0010257)4.24153085
12mitochondrial respiratory chain complex assembly (GO:0033108)4.18253453
13protein complex biogenesis (GO:0070271)4.17883823
14DNA strand elongation involved in DNA replication (GO:0006271)4.11611353
15formation of translation preinitiation complex (GO:0001731)4.05397209
16ribosomal small subunit biogenesis (GO:0042274)4.05291859
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98061178
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.93249842
19telomere maintenance via semi-conservative replication (GO:0032201)3.92813547
20translational initiation (GO:0006413)3.90993088
21DNA strand elongation (GO:0022616)3.88686175
22folic acid-containing compound biosynthetic process (GO:0009396)3.85625278
23protein targeting to ER (GO:0045047)3.84819311
24cotranslational protein targeting to membrane (GO:0006613)3.82868803
25peptidyl-histidine modification (GO:0018202)3.82751000
26DNA replication initiation (GO:0006270)3.76798899
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75716225
28DNA unwinding involved in DNA replication (GO:0006268)3.74021385
29chaperone-mediated protein transport (GO:0072321)3.72765778
30protein localization to endoplasmic reticulum (GO:0070972)3.67669172
31viral life cycle (GO:0019058)3.66375491
32replication fork processing (GO:0031297)3.66212697
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64753858
34nucleobase biosynthetic process (GO:0046112)3.62179349
35cellular protein complex disassembly (GO:0043624)3.54111903
36ribosomal large subunit biogenesis (GO:0042273)3.48846907
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47504041
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46960114
39DNA double-strand break processing (GO:0000729)3.45678500
40rRNA modification (GO:0000154)3.44844937
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42637299
42ribonucleoprotein complex biogenesis (GO:0022613)3.42350844
43pentose-phosphate shunt (GO:0006098)3.41646004
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38780142
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38780142
46chromatin remodeling at centromere (GO:0031055)3.36792313
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35361108
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35361108
49IMP biosynthetic process (GO:0006188)3.35283929
50protein targeting to mitochondrion (GO:0006626)3.31750233
51purine nucleobase biosynthetic process (GO:0009113)3.30704455
52ribosome biogenesis (GO:0042254)3.27971954
53IMP metabolic process (GO:0046040)3.25752590
54telomere maintenance via recombination (GO:0000722)3.23181504
55cullin deneddylation (GO:0010388)3.22299065
56folic acid metabolic process (GO:0046655)3.21470289
57respiratory chain complex IV assembly (GO:0008535)3.21276664
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19756725
59tRNA processing (GO:0008033)3.19626726
60protein complex disassembly (GO:0043241)3.18318338
61protein deneddylation (GO:0000338)3.16461949
62DNA catabolic process, exonucleolytic (GO:0000738)3.13324564
63pteridine-containing compound biosynthetic process (GO:0042559)3.13096578
64CENP-A containing nucleosome assembly (GO:0034080)3.12829567
65ATP synthesis coupled proton transport (GO:0015986)3.12364490
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12364490
67tRNA modification (GO:0006400)3.10793379
68termination of RNA polymerase III transcription (GO:0006386)3.10756579
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.10756579
70transcription-coupled nucleotide-excision repair (GO:0006283)3.10098807
71establishment of protein localization to mitochondrion (GO:0072655)3.09250363
72tRNA metabolic process (GO:0006399)3.09204897
73cytochrome complex assembly (GO:0017004)3.08770721
74glycine metabolic process (GO:0006544)3.08596373
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06209871
76protein localization to mitochondrion (GO:0070585)3.05218290
77pseudouridine synthesis (GO:0001522)3.04440246
78viral mRNA export from host cell nucleus (GO:0046784)3.01615530
79macromolecular complex disassembly (GO:0032984)3.00293897
80translation (GO:0006412)2.98372484
81* ncRNA processing (GO:0034470)2.98178916
82NADPH regeneration (GO:0006740)2.97801310
83inner mitochondrial membrane organization (GO:0007007)2.97650370
84translesion synthesis (GO:0019985)2.97123712
85* ncRNA metabolic process (GO:0034660)2.94954855
86DNA replication checkpoint (GO:0000076)2.92524763
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92444239
88amino acid salvage (GO:0043102)2.91156659
89L-methionine salvage (GO:0071267)2.91156659
90L-methionine biosynthetic process (GO:0071265)2.91156659
91mannosylation (GO:0097502)2.90910433
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90382485
93telomere maintenance via telomere lengthening (GO:0010833)2.89692641
94transcription from mitochondrial promoter (GO:0006390)2.89278908
95maturation of 5.8S rRNA (GO:0000460)2.88437870
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.88014665
97mitotic recombination (GO:0006312)2.87382820
98ribosome assembly (GO:0042255)2.87380785
99mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85447008
100* rRNA processing (GO:0006364)2.85073232
101pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.84952610
102meiotic chromosome segregation (GO:0045132)2.82293000
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82097702
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.82097702
105RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.81802513
106postreplication repair (GO:0006301)2.81078421
107rRNA methylation (GO:0031167)2.79729673
108pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78788342
109amino acid activation (GO:0043038)2.77633147
110tRNA aminoacylation (GO:0043039)2.77633147
111ubiquinone biosynthetic process (GO:0006744)2.77263714
112tRNA aminoacylation for protein translation (GO:0006418)2.76663140
1137-methylguanosine mRNA capping (GO:0006370)2.75423134
114termination of RNA polymerase I transcription (GO:0006363)2.74798906
115* rRNA metabolic process (GO:0016072)2.74473831
116antigen processing and presentation of endogenous antigen (GO:0019883)2.72902171
117mRNA catabolic process (GO:0006402)2.72513343
118proteasome assembly (GO:0043248)2.71943965
119RNA catabolic process (GO:0006401)2.71822790
120nucleoside salvage (GO:0043174)2.69551540
121pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.66653364
122oxidative phosphorylation (GO:0006119)2.61127248
123protein localization to kinetochore (GO:0034501)2.59883009
124cellular component biogenesis (GO:0044085)2.58927443
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.58407107
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57787247
127protein targeting to membrane (GO:0006612)2.55971497
128serine family amino acid biosynthetic process (GO:0009070)2.55892693
129nucleotide salvage (GO:0043173)2.53907909
130mitotic nuclear envelope disassembly (GO:0007077)2.53321039
131pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.52383209
132UMP biosynthetic process (GO:0006222)2.52383209
133pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.52383209
134UMP metabolic process (GO:0046049)2.52383209
135mitochondrial RNA metabolic process (GO:0000959)2.50376776
136mitotic G1 DNA damage checkpoint (GO:0031571)2.49720534
137ncRNA 3-end processing (GO:0043628)2.49014145
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48462105
139tetrahydrofolate metabolic process (GO:0046653)2.47236918
140nucleobase-containing small molecule interconversion (GO:0015949)2.46568993
141mitochondrial DNA metabolic process (GO:0032042)2.45530623
142glucose catabolic process (GO:0006007)2.43852443
143T cell apoptotic process (GO:0070231)2.41942014
144L-serine metabolic process (GO:0006563)2.41568413
145antigen processing and presentation via MHC class Ib (GO:0002475)2.40541808
146spliceosomal snRNP assembly (GO:0000387)2.40319332
147regulation of translational termination (GO:0006449)2.38185651
148regulation of translational fidelity (GO:0006450)2.36980947
149iron-sulfur cluster assembly (GO:0016226)2.35981437
150metallo-sulfur cluster assembly (GO:0031163)2.35981437
151mitochondrial DNA replication (GO:0006264)2.35773605
152AMP metabolic process (GO:0046033)2.35288933
153folic acid-containing compound metabolic process (GO:0006760)2.35157914
154antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.34862159
155DNA replication-dependent nucleosome assembly (GO:0006335)2.34541157
156DNA replication-dependent nucleosome organization (GO:0034723)2.34541157
157negative regulation of RNA splicing (GO:0033119)2.34193925
158negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.34172518
159negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.34151817
160pteridine-containing compound metabolic process (GO:0042558)2.33953867
161anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.33081761
162regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.32769363
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32633147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52513577
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.37425008
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02556114
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47073524
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47734199
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38014729
7MYC_22102868_ChIP-Seq_BL_Human2.31300431
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27141177
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26789795
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.22577153
11ZNF274_21170338_ChIP-Seq_K562_Hela2.20135078
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19347205
13ELK1_19687146_ChIP-ChIP_HELA_Human2.16774949
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.11794822
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.07248263
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06056470
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04900526
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04091666
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03771955
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02603966
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.02354152
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98841807
23XRN2_22483619_ChIP-Seq_HELA_Human1.97880807
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96555080
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94409130
26VDR_21846776_ChIP-Seq_THP-1_Human1.93055396
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89399730
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89048733
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88121195
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87576944
31MYC_18940864_ChIP-ChIP_HL60_Human1.85025792
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81844213
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78979924
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78108237
35VDR_23849224_ChIP-Seq_CD4+_Human1.75236641
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.73177701
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71364281
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70766308
39DCP1A_22483619_ChIP-Seq_HELA_Human1.61835205
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61642769
41GABP_19822575_ChIP-Seq_HepG2_Human1.58694814
42FOXP3_21729870_ChIP-Seq_TREG_Human1.55076312
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53532632
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52033721
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51152726
46CIITA_25753668_ChIP-Seq_RAJI_Human1.51010305
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49689129
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45438708
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44552905
50SCL_19346495_ChIP-Seq_HPC-7_Human1.42435309
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41526553
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41319139
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37597277
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37186926
55* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36978456
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36678156
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36431197
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34656405
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34641558
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34222102
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34183369
62EWS_26573619_Chip-Seq_HEK293_Human1.33133985
63IGF1R_20145208_ChIP-Seq_DFB_Human1.33122589
64ZNF263_19887448_ChIP-Seq_K562_Human1.32821391
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31861773
66SPI1_23547873_ChIP-Seq_NB4_Human1.31294568
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31000801
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29910983
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.28759011
70TTF2_22483619_ChIP-Seq_HELA_Human1.28559553
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.28428526
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.27872227
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.26653177
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25549756
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25355127
76KDM5A_27292631_Chip-Seq_BREAST_Human1.24046993
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.22511871
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22238782
79MAF_26560356_Chip-Seq_TH1_Human1.21931392
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21662512
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21510218
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20761501
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18089091
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17769238
85AR_21909140_ChIP-Seq_LNCAP_Human1.17043636
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16823304
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.16716789
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15736425
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15692868
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14698839
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14430607
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14294453
93UTX_26944678_Chip-Seq_JUKART_Human1.13843959
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11887273
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.11573306
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10609075
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10220618
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10217238
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.10160615
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10153700
101TFEB_21752829_ChIP-Seq_HELA_Human1.07980269
102IRF1_19129219_ChIP-ChIP_H3396_Human1.06628318
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06498120
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06447214
105TCF7_22412390_ChIP-Seq_EML_Mouse1.05985478
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05931515
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05711187
108MAF_26560356_Chip-Seq_TH2_Human1.04702474
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04209125
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.03629905
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02625290
112VDR_24763502_ChIP-Seq_THP-1_Human1.00013686
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98746761
114GATA1_22025678_ChIP-Seq_K562_Human0.98275082
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.97498342
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97430728
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96451244
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96404043
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95990003
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94739480
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94465768
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94320904
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91221315
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87473013
125TP53_22573176_ChIP-Seq_HFKS_Human0.86993363
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86583132
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84064840
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82195095
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81897879
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80299338
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78251760
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76241272
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.74199441
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.72790548
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72565735
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71052169
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70116919
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70055314
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69092448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.51381115
2MP0003806_abnormal_nucleotide_metabolis3.28387095
3MP0002396_abnormal_hematopoietic_system2.99312800
4MP0009840_abnormal_foam_cell2.75257683
5MP0004957_abnormal_blastocyst_morpholog2.70551721
6MP0000372_irregular_coat_pigmentation2.68438657
7MP0001529_abnormal_vocalization2.55552318
8MP0003111_abnormal_nucleus_morphology2.43935578
9MP0009697_abnormal_copulation2.41713426
10MP0003718_maternal_effect2.39401457
11MP0010094_abnormal_chromosome_stability2.37809769
12MP0001545_abnormal_hematopoietic_system2.28212956
13MP0005397_hematopoietic_system_phenotyp2.28212956
14MP0002102_abnormal_ear_morphology2.20666402
15MP0003077_abnormal_cell_cycle2.16922050
16MP0002234_abnormal_pharynx_morphology2.11019665
17MP0002139_abnormal_hepatobiliary_system2.06569048
18MP0008877_abnormal_DNA_methylation2.01060411
19MP0003191_abnormal_cellular_cholesterol1.99145831
20MP0003436_decreased_susceptibility_to1.91909312
21MP0008995_early_reproductive_senescence1.85502166
22MP0002160_abnormal_reproductive_system1.82576306
23MP0005360_urolithiasis1.81888776
24MP0004808_abnormal_hematopoietic_stem1.81764808
25MP0001853_heart_inflammation1.79825547
26MP0002736_abnormal_nociception_after1.79220426
27MP0009278_abnormal_bone_marrow1.78937249
28MP0005646_abnormal_pituitary_gland1.78380360
29MP0009333_abnormal_splenocyte_physiolog1.77752601
30MP0005365_abnormal_bile_salt1.77318899
31MP0000490_abnormal_crypts_of1.74086161
32MP0006072_abnormal_retinal_apoptosis1.72808965
33MP0000685_abnormal_immune_system1.69285840
34MP0006036_abnormal_mitochondrial_physio1.69238277
35MP0003656_abnormal_erythrocyte_physiolo1.68517685
36MP0008007_abnormal_cellular_replicative1.65689355
37MP0010352_gastrointestinal_tract_polyps1.64537204
38MP0002938_white_spotting1.62979186
39MP0008058_abnormal_DNA_repair1.61925449
40MP0006292_abnormal_olfactory_placode1.61660032
41MP0002398_abnormal_bone_marrow1.61657553
42MP0000689_abnormal_spleen_morphology1.59216707
43MP0003186_abnormal_redox_activity1.58500605
44MP0001835_abnormal_antigen_presentation1.58293177
45MP0003763_abnormal_thymus_physiology1.55916423
46MP0005085_abnormal_gallbladder_physiolo1.54142125
47MP0002722_abnormal_immune_system1.53891899
48MP0005464_abnormal_platelet_physiology1.50980880
49MP0002019_abnormal_tumor_incidence1.44454002
50MP0001800_abnormal_humoral_immune1.39165301
51MP0005025_abnormal_response_to1.38273938
52MP0002837_dystrophic_cardiac_calcinosis1.37558153
53MP0009785_altered_susceptibility_to1.37071746
54MP0001730_embryonic_growth_arrest1.36509648
55MP0002429_abnormal_blood_cell1.36211503
56MP0008789_abnormal_olfactory_epithelium1.32368423
57MP0005319_abnormal_enzyme/_coenzyme1.31953561
58MP0001968_abnormal_touch/_nociception1.29764227
59MP0008057_abnormal_DNA_replication1.29235055
60MP0000716_abnormal_immune_system1.28216023
61MP0000858_altered_metastatic_potential1.27788227
62MP0001661_extended_life_span1.27292673
63MP0002420_abnormal_adaptive_immunity1.26271090
64MP0001819_abnormal_immune_cell1.24914601
65MP0000609_abnormal_liver_physiology1.24130187
66MP0002452_abnormal_antigen_presenting1.23705945
67MP0000703_abnormal_thymus_morphology1.23624841
68MP0002210_abnormal_sex_determination1.23354821
69MP0010307_abnormal_tumor_latency1.21814292
70MP0002723_abnormal_immune_serum1.20344376
71MP0000350_abnormal_cell_proliferation1.20215082
72MP0003937_abnormal_limbs/digits/tail_de1.20028047
73MP0002166_altered_tumor_susceptibility1.19926660
74MP0001873_stomach_inflammation1.18389635
75MP0002405_respiratory_system_inflammati1.18094662
76MP0005645_abnormal_hypothalamus_physiol1.16643844
77MP0005083_abnormal_biliary_tract1.15877214
78MP0000049_abnormal_middle_ear1.15103810
79MP0005075_abnormal_melanosome_morpholog1.15067542
80MP0001929_abnormal_gametogenesis1.14414550
81MP0000598_abnormal_liver_morphology1.14086696
82MP0000465_gastrointestinal_hemorrhage1.14063614
83MP0000313_abnormal_cell_death1.13887759
84MP0005389_reproductive_system_phenotype1.13503093
85MP0003195_calcinosis1.11882073
86MP0008469_abnormal_protein_level1.11781256
87MP0002419_abnormal_innate_immunity1.11715062
88MP0003303_peritoneal_inflammation1.09909445
89MP0001764_abnormal_homeostasis1.09424244
90MP0000358_abnormal_cell_content/1.09271075
91MP0010155_abnormal_intestine_physiology1.08108154
92MP0005671_abnormal_response_to1.07616255
93MP0003221_abnormal_cardiomyocyte_apopto1.07584245
94MP0010329_abnormal_lipoprotein_level1.07291745
95MP0001293_anophthalmia1.07124621
96MP0001145_abnormal_male_reproductive1.07021441
97MP0005394_taste/olfaction_phenotype1.06723508
98MP0005499_abnormal_olfactory_system1.06723508
99MP0004043_abnormal_pH_regulation1.06464612
100MP0005000_abnormal_immune_tolerance1.06053794
101MP0006035_abnormal_mitochondrial_morpho1.05912685
102MP0003705_abnormal_hypodermis_morpholog1.05787231
103MP0002080_prenatal_lethality1.05761516
104MP0000653_abnormal_sex_gland1.04698894
105MP0001845_abnormal_inflammatory_respons1.03792973
106MP0000343_altered_response_to1.03266306
107MP0003786_premature_aging1.02758697
108MP0002163_abnormal_gland_morphology1.01421666
109MP0003315_abnormal_perineum_morphology1.01307871
110MP0002751_abnormal_autonomic_nervous1.00230547
111MP0008875_abnormal_xenobiotic_pharmacok0.98638677
112MP0005023_abnormal_wound_healing0.97996393
113MP0003698_abnormal_male_reproductive0.97299434
114MP0003724_increased_susceptibility_to0.97193760
115MP0000631_abnormal_neuroendocrine_gland0.97088112
116MP0006276_abnormal_autonomic_nervous0.97059156
117MP0006054_spinal_hemorrhage0.97051709
118MP0003566_abnormal_cell_adhesion0.95593693
119MP0002138_abnormal_hepatobiliary_system0.95531655
120MP0002095_abnormal_skin_pigmentation0.91643345
121MP0004147_increased_porphyrin_level0.91589919
122MP0003567_abnormal_fetal_cardiomyocyte0.91570727
123MP0005253_abnormal_eye_physiology0.91429968
124MP0001697_abnormal_embryo_size0.90684800
125MP0008872_abnormal_physiological_respon0.90526580
126MP0004947_skin_inflammation0.89828173
127MP0004133_heterotaxia0.88928733
128MP0002876_abnormal_thyroid_physiology0.88409730
129MP0002086_abnormal_extraembryonic_tissu0.88209483
130MP0005332_abnormal_amino_acid0.86573109
131MP0005058_abnormal_lysosome_morphology0.86373660
132MP0005266_abnormal_metabolism0.86289776
133MP0003119_abnormal_digestive_system0.84990385
134MP0002132_abnormal_respiratory_system0.84655664
135MP0009643_abnormal_urine_homeostasis0.84509460
136MP0005551_abnormal_eye_electrophysiolog0.84487733
137MP0005670_abnormal_white_adipose0.84022217
138MP0008932_abnormal_embryonic_tissue0.83783196
139MP0000015_abnormal_ear_pigmentation0.82846313
140MP0003984_embryonic_growth_retardation0.82587586
141MP0005220_abnormal_exocrine_pancreas0.82429642
142MP0005584_abnormal_enzyme/coenzyme_acti0.81903665
143MP0001672_abnormal_embryogenesis/_devel0.81884323
144MP0005380_embryogenesis_phenotype0.81884323
145MP0001986_abnormal_taste_sensitivity0.81796147
146MP0002088_abnormal_embryonic_growth/wei0.81711131
147MP0009763_increased_sensitivity_to0.81586255
148MP0003646_muscle_fatigue0.81514222
149MP0001984_abnormal_olfaction0.80534057
150MP0003283_abnormal_digestive_organ0.75872278
151MP0009672_abnormal_birth_weight0.75786668
152MP0001119_abnormal_female_reproductive0.73363929
153MP0005084_abnormal_gallbladder_morpholo0.72289423
154MP0001919_abnormal_reproductive_system0.71238978
155MP0000538_abnormal_urinary_bladder0.71037405
156MP0002233_abnormal_nose_morphology0.69289699
157MP0001324_abnormal_eye_pigmentation0.69089048
158MP0005410_abnormal_fertilization0.68522848
159MP0002085_abnormal_embryonic_tissue0.65755947
160MP0001270_distended_abdomen0.64802244
161MP0003385_abnormal_body_wall0.63761558
162MP0005379_endocrine/exocrine_gland_phen0.63372367

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.71211264
2Abnormal number of erythroid precursors (HP:0012131)4.54340230
3Acute necrotizing encephalopathy (HP:0006965)4.22740062
4Abnormal mitochondria in muscle tissue (HP:0008316)4.11212910
5Acute encephalopathy (HP:0006846)4.07246696
6Increased CSF lactate (HP:0002490)3.99569511
7Mitochondrial inheritance (HP:0001427)3.99468022
8Reticulocytopenia (HP:0001896)3.80204552
9Progressive macrocephaly (HP:0004481)3.37964071
10Thrombocytosis (HP:0001894)3.35527616
11Lipid accumulation in hepatocytes (HP:0006561)3.25600076
12Increased hepatocellular lipid droplets (HP:0006565)3.24777912
13Microvesicular hepatic steatosis (HP:0001414)3.14275948
14Cerebral edema (HP:0002181)3.02834856
15Macrocytic anemia (HP:0001972)2.99206729
16Petechiae (HP:0000967)2.98081773
17Aplastic anemia (HP:0001915)2.96526165
18Multiple enchondromatosis (HP:0005701)2.95263805
19Oral leukoplakia (HP:0002745)2.81059508
20Progressive muscle weakness (HP:0003323)2.80571906
21IgM deficiency (HP:0002850)2.80499822
22Microretrognathia (HP:0000308)2.79287765
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75851148
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75851148
25Increased serum pyruvate (HP:0003542)2.75254942
26Pallor (HP:0000980)2.70753391
27Chromsome breakage (HP:0040012)2.69439380
28Birth length less than 3rd percentile (HP:0003561)2.67658856
29Abnormal protein glycosylation (HP:0012346)2.67346072
30Abnormal glycosylation (HP:0012345)2.67346072
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67346072
32Abnormal protein N-linked glycosylation (HP:0012347)2.67346072
33Elevated erythrocyte sedimentation rate (HP:0003565)2.65932275
343-Methylglutaconic aciduria (HP:0003535)2.62794853
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62163681
36Abnormality of glycolysis (HP:0004366)2.62053510
37Abnormality of the ileum (HP:0001549)2.53341638
38Meckel diverticulum (HP:0002245)2.52574005
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50844634
40Abnormality of pyrimidine metabolism (HP:0004353)2.49388513
41Increased serum ferritin (HP:0003281)2.48747717
42Hyperammonemia (HP:0001987)2.48576282
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48529908
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.47891882
45Renal Fanconi syndrome (HP:0001994)2.47480608
46Abnormality of fatty-acid metabolism (HP:0004359)2.45657328
47Respiratory failure (HP:0002878)2.44006487
48Exercise intolerance (HP:0003546)2.40022002
49Opisthotonus (HP:0002179)2.36505051
50Aplasia/Hypoplasia of the patella (HP:0006498)2.35651277
51Chronic otitis media (HP:0000389)2.35566488
52Abnormality of T cell physiology (HP:0011840)2.35182199
53Rhabdomyolysis (HP:0003201)2.33110390
54Abnormality of the preputium (HP:0100587)2.31839415
55Dicarboxylic aciduria (HP:0003215)2.31363087
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31363087
57Impaired platelet aggregation (HP:0003540)2.29221196
58Abnormal platelet function (HP:0011869)2.29221196
59Abnormality of the labia minora (HP:0012880)2.27712358
60Hepatic necrosis (HP:0002605)2.27640997
61Pendular nystagmus (HP:0012043)2.27423726
62Reduced antithrombin III activity (HP:0001976)2.26649965
63Selective tooth agenesis (HP:0001592)2.26097854
64Ragged-red muscle fibers (HP:0003200)2.25049912
65Abnormality of iron homeostasis (HP:0011031)2.24230323
66Colon cancer (HP:0003003)2.22419408
67Abnormality of reticulocytes (HP:0004312)2.22042168
68Microcytic anemia (HP:0001935)2.21882177
69Hypobetalipoproteinemia (HP:0003563)2.18988598
70Abnormality of the heme biosynthetic pathway (HP:0010472)2.18105389
71Abnormality of the nasal mucosa (HP:0000433)2.17978778
72Type II lissencephaly (HP:0007260)2.16670478
73Optic disc pallor (HP:0000543)2.15978976
74Increased muscle lipid content (HP:0009058)2.15172369
75Poikiloderma (HP:0001029)2.15124006
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14951486
77Hypoplasia of the pons (HP:0012110)2.14818849
78Basal cell carcinoma (HP:0002671)2.13890435
79Patellar aplasia (HP:0006443)2.13772505
80Nausea (HP:0002018)2.13568014
81Panhypogammaglobulinemia (HP:0003139)2.10340484
82Abnormality of DNA repair (HP:0003254)2.10330913
83Lethargy (HP:0001254)2.07310962
84Renal cortical cysts (HP:0000803)2.07308274
85Pustule (HP:0200039)2.07278768
86Progressive microcephaly (HP:0000253)2.06927623
87Prolonged bleeding time (HP:0003010)2.06805770
88Abnormality of midbrain morphology (HP:0002418)2.04240033
89Molar tooth sign on MRI (HP:0002419)2.04240033
90Spastic diplegia (HP:0001264)2.04232321
91Degeneration of anterior horn cells (HP:0002398)2.03547283
92Abnormality of the anterior horn cell (HP:0006802)2.03547283
93Abnormality of transition element cation homeostasis (HP:0011030)2.02576083
94Pancreatic cysts (HP:0001737)2.01818952
95Epistaxis (HP:0000421)2.01791437
96Increased serum lactate (HP:0002151)2.01384095
97Abnormality of chromosome stability (HP:0003220)2.01344965
98Abnormality of the pons (HP:0007361)2.00240267
99Hepatocellular necrosis (HP:0001404)1.99743934
100Exertional dyspnea (HP:0002875)1.98957422
101Recurrent abscess formation (HP:0002722)1.98055965
102Hyperglycinuria (HP:0003108)1.97609191
103Nephronophthisis (HP:0000090)1.97137257
104Xanthomatosis (HP:0000991)1.96413628
105Increased intramyocellular lipid droplets (HP:0012240)1.96008720
106Polycythemia (HP:0001901)1.95758050
107Spontaneous hematomas (HP:0007420)1.94519896
108Cerebral hypomyelination (HP:0006808)1.93835390
109Hypoglycemic coma (HP:0001325)1.93812330
110Premature ovarian failure (HP:0008209)1.92632917
111Megaloblastic anemia (HP:0001889)1.92439302
112Agnosia (HP:0010524)1.91532943
113Methylmalonic aciduria (HP:0012120)1.90879288
114Late onset (HP:0003584)1.90588971
115Methylmalonic acidemia (HP:0002912)1.90058399
116Nasal polyposis (HP:0100582)1.89702733
117Absent thumb (HP:0009777)1.89348731
118Myositis (HP:0100614)1.89289476
119Ketosis (HP:0001946)1.89189803
120Pancytopenia (HP:0001876)1.87817656
121Generalized aminoaciduria (HP:0002909)1.87597598
122Hyperglycinemia (HP:0002154)1.86787602
123Sloping forehead (HP:0000340)1.86431738
124Horseshoe kidney (HP:0000085)1.85563067
125Squamous cell carcinoma (HP:0002860)1.84647186
126Acute lymphatic leukemia (HP:0006721)1.83777745
127Breast hypoplasia (HP:0003187)1.83503417
128Pancreatic fibrosis (HP:0100732)1.82290440
129Respiratory difficulties (HP:0002880)1.82288674
130Testicular atrophy (HP:0000029)1.80400997
131Abnormality of T cells (HP:0002843)1.79985269
132Rough bone trabeculation (HP:0100670)1.79825096
133Abnormality of serum amino acid levels (HP:0003112)1.79389844
134Recurrent bacterial skin infections (HP:0005406)1.79389708
135Entropion (HP:0000621)1.79299780
136Abnormality of glycine metabolism (HP:0010895)1.78756369
137Abnormality of serine family amino acid metabolism (HP:0010894)1.78756369
138Pachygyria (HP:0001302)1.77469339
139Trismus (HP:0000211)1.77358565
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76632440
141Abnormality of alanine metabolism (HP:0010916)1.76632440
142Hyperalaninemia (HP:0003348)1.76632440
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76455955
144Intrahepatic cholestasis (HP:0001406)1.76443687
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76186421
146Eczematoid dermatitis (HP:0000976)1.75656494
147Small intestinal stenosis (HP:0012848)1.75122781
148Duodenal stenosis (HP:0100867)1.75122781
149Emotional lability (HP:0000712)1.74793991
150Fibular aplasia (HP:0002990)1.74731345
151Lissencephaly (HP:0001339)1.73234058
152Myoglobinuria (HP:0002913)1.72429301
153Type I transferrin isoform profile (HP:0003642)1.72275543
154Hyperbilirubinemia (HP:0002904)1.71926814
155Cerebellar dysplasia (HP:0007033)1.71728570
156True hermaphroditism (HP:0010459)1.71602258
157Gastrointestinal inflammation (HP:0004386)1.70409742
158Leukodystrophy (HP:0002415)1.70344628
159Recurrent gram-negative bacterial infections (HP:0005420)1.69925805
160Hypochromic anemia (HP:0001931)1.69060806
161Retinal dysplasia (HP:0007973)1.68332305
162Chronic hepatic failure (HP:0100626)1.68059313
163Delayed CNS myelination (HP:0002188)1.67369688
164Poor head control (HP:0002421)1.67238304
165Lactic acidosis (HP:0003128)1.66532840
166CNS demyelination (HP:0007305)1.65531766
167Neoplasm of the pancreas (HP:0002894)1.64980242
168Personality changes (HP:0000751)1.63500348
169Ependymoma (HP:0002888)1.63126502
170Abnormality of the motor neurons (HP:0002450)1.62171205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.13370575
2NME23.40895589
3WEE13.13534709
4PKN22.85652757
5BMPR1B2.82628918
6BCKDK2.73633328
7BUB12.65938721
8NUAK12.62677178
9TRIB32.55701565
10ZAK2.48866086
11FLT32.46481022
12MAP4K22.35868480
13CDK82.32250924
14STK162.26636720
15ERN12.26025769
16SRPK12.22810184
17MAP4K12.20538912
18MAP2K32.19189030
19EEF2K2.16651690
20KDR2.10197231
21MAPKAPK32.00558613
22NEK21.90413367
23PBK1.86492316
24SCYL21.84134389
25TESK21.77667171
26TRIM281.76215936
27MAP3K111.74891127
28RPS6KB21.73087146
29MAP2K71.73023411
30NEK11.67873063
31MAP3K101.66086955
32TIE11.65237377
33PIM21.64556969
34ACVR1B1.64499247
35BLK1.63627298
36CDC71.60657881
37TAF11.59885271
38KIT1.58310023
39FRK1.57470093
40LRRK21.55900204
41DYRK31.45916206
42CSNK1G31.45452024
43WNK31.42181115
44RPS6KA41.42029454
45TEC1.41600935
46EIF2AK11.39366408
47MKNK11.38556911
48ZAP701.37502701
49STK101.35825098
50BTK1.35251768
51GRK11.35166707
52CDK41.32848213
53PINK11.32199892
54GRK61.30715858
55TGFBR11.29493446
56NME11.25608650
57PLK31.24634853
58CDK71.24621655
59CSNK1A1L1.22451486
60BCR1.21324435
61TYK21.19826193
62TGFBR21.19110146
63ADRBK21.16716205
64CDK91.16670657
65PAK41.15621117
66DYRK21.15184260
67TBK11.14186375
68CSNK1G11.14092201
69CSF1R1.12392072
70MAP3K81.11188403
71PASK1.10956874
72MST41.09703488
73CSNK1G21.07002181
74MKNK21.06121717
75PIM11.04878024
76MAP3K30.98131402
77TSSK60.96726772
78BRSK20.95006213
79ATM0.86035612
80PLK10.85644819
81MAP2K20.84041192
82VRK10.83831820
83EIF2AK30.83005342
84TTK0.81537533
85TTN0.81215596
86MAP3K40.80965930
87CLK10.78953657
88MAPK110.78443487
89AURKB0.77692231
90TLK10.77562246
91RPS6KA50.77451957
92JAK30.75381726
93ATR0.75152597
94EIF2AK20.73511264
95PDK20.70339268
96CCNB10.70307926
97ILK0.69790703
98WNK40.66603063
99AURKA0.66290067
100SYK0.63366523
101SMG10.63083650
102IRAK40.61634660
103TAOK30.61503233
104MAP2K60.61278539
105TESK10.61189385
106RAF10.57660112
107STK40.56161782
108MAPK130.55343942
109INSRR0.54844204
110IRAK30.54618991
111EPHA20.53627995
112MATK0.53574280
113TAOK20.52811109
114CDK190.52698949
115PRKG20.52362402
116TAOK10.50765034
117CDK60.49496076
118FGFR40.49482702
119MAPK40.49127885
120MAPKAPK50.48949608
121BRSK10.46280526
122PLK20.45469704
123DAPK10.44818623
124CSNK2A20.44166150
125PRKD30.44150786
126PNCK0.43139178
127CSNK1E0.42781627
128CDK20.42122681
129ALK0.40428595
130PAK10.39820452
131ERBB30.39723177
132LYN0.38157066
133JAK20.37961560
134IKBKB0.37781533
135LCK0.36719577
136CSNK1A10.36679679
137RPS6KA60.36249540
138CDK30.36117107
139CSNK2A10.35889764
140MAP3K50.35368395
141RPS6KC10.34779119
142RPS6KL10.34779119
143CHEK20.34564661
144CDK10.33575209
145ITK0.33134698
146ABL20.33102916
147OBSCN0.32359296
148CDK120.32331471
149PRKCI0.32279513
150DAPK30.32164261
151CSK0.32161199
152CHEK10.31452056
153PLK40.29752896
154PRKDC0.28005708
155MARK30.24953470
156RPS6KB10.24952684
157LATS10.24503046

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34864727
2Ribosome_Homo sapiens_hsa030103.84274002
3Mismatch repair_Homo sapiens_hsa034303.15534581
4Proteasome_Homo sapiens_hsa030502.55585013
5Base excision repair_Homo sapiens_hsa034102.48484996
6Oxidative phosphorylation_Homo sapiens_hsa001902.39184994
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38855969
8Sulfur relay system_Homo sapiens_hsa041222.37172689
9One carbon pool by folate_Homo sapiens_hsa006702.23300122
10Spliceosome_Homo sapiens_hsa030402.11893840
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09231126
12Pyrimidine metabolism_Homo sapiens_hsa002402.08921029
13RNA polymerase_Homo sapiens_hsa030202.02271895
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98687855
15Folate biosynthesis_Homo sapiens_hsa007901.98078885
16Protein export_Homo sapiens_hsa030601.92983259
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91707505
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87459749
19RNA transport_Homo sapiens_hsa030131.83533836
20Nucleotide excision repair_Homo sapiens_hsa034201.83524473
21Pentose phosphate pathway_Homo sapiens_hsa000301.82290253
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81437968
23Homologous recombination_Homo sapiens_hsa034401.74169636
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.69209134
25Biosynthesis of amino acids_Homo sapiens_hsa012301.67958510
26Huntingtons disease_Homo sapiens_hsa050161.65237989
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62889155
28Selenocompound metabolism_Homo sapiens_hsa004501.59769725
29Carbon metabolism_Homo sapiens_hsa012001.58551514
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.47665675
31Butanoate metabolism_Homo sapiens_hsa006501.45723427
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45657654
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.38178329
34Cell cycle_Homo sapiens_hsa041101.36107901
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28286060
36Fatty acid degradation_Homo sapiens_hsa000711.21166845
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19594443
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19455502
39Alzheimers disease_Homo sapiens_hsa050101.16462147
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15124354
41Fatty acid elongation_Homo sapiens_hsa000621.14659574
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.13829506
43Caffeine metabolism_Homo sapiens_hsa002321.11537863
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11153911
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03482341
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03395759
47p53 signaling pathway_Homo sapiens_hsa041151.02978706
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02645980
49Steroid biosynthesis_Homo sapiens_hsa001000.99465876
50Antigen processing and presentation_Homo sapiens_hsa046120.93349815
51Fructose and mannose metabolism_Homo sapiens_hsa000510.93106509
52Galactose metabolism_Homo sapiens_hsa000520.91040193
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90625567
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88341401
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86900724
56Purine metabolism_Homo sapiens_hsa002300.85925763
57RNA degradation_Homo sapiens_hsa030180.82998202
58Systemic lupus erythematosus_Homo sapiens_hsa053220.81485282
59Primary immunodeficiency_Homo sapiens_hsa053400.81268877
60Staphylococcus aureus infection_Homo sapiens_hsa051500.80285159
61Propanoate metabolism_Homo sapiens_hsa006400.80228581
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80149692
63Glutathione metabolism_Homo sapiens_hsa004800.79104950
64Epstein-Barr virus infection_Homo sapiens_hsa051690.78161957
65Pyruvate metabolism_Homo sapiens_hsa006200.77104834
66Herpes simplex infection_Homo sapiens_hsa051680.77072482
67Non-homologous end-joining_Homo sapiens_hsa034500.74342006
68Other glycan degradation_Homo sapiens_hsa005110.73153731
69Legionellosis_Homo sapiens_hsa051340.71404793
70Peroxisome_Homo sapiens_hsa041460.70136006
71Acute myeloid leukemia_Homo sapiens_hsa052210.68610028
72Arginine biosynthesis_Homo sapiens_hsa002200.67769500
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63643488
74Fanconi anemia pathway_Homo sapiens_hsa034600.63575727
75Tryptophan metabolism_Homo sapiens_hsa003800.62974393
76beta-Alanine metabolism_Homo sapiens_hsa004100.62791975
77Thyroid cancer_Homo sapiens_hsa052160.60705059
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59595839
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58122327
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57479246
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56923513
82Regulation of autophagy_Homo sapiens_hsa041400.56218067
83Viral carcinogenesis_Homo sapiens_hsa052030.55134491
84N-Glycan biosynthesis_Homo sapiens_hsa005100.54713123
85Leishmaniasis_Homo sapiens_hsa051400.54694118
86Complement and coagulation cascades_Homo sapiens_hsa046100.50128351
87Fatty acid metabolism_Homo sapiens_hsa012120.49356700
88Apoptosis_Homo sapiens_hsa042100.49251258
89Phototransduction_Homo sapiens_hsa047440.47748783
90PPAR signaling pathway_Homo sapiens_hsa033200.46722722
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46278099
92B cell receptor signaling pathway_Homo sapiens_hsa046620.45785520
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45751726
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.45418168
95Shigellosis_Homo sapiens_hsa051310.44931006
96Arginine and proline metabolism_Homo sapiens_hsa003300.43147358
97Parkinsons disease_Homo sapiens_hsa050120.42821922
98Lysine degradation_Homo sapiens_hsa003100.42742026
99Metabolic pathways_Homo sapiens_hsa011000.42147349
100Starch and sucrose metabolism_Homo sapiens_hsa005000.41817703
101Sulfur metabolism_Homo sapiens_hsa009200.41729530
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40117896
103Nitrogen metabolism_Homo sapiens_hsa009100.38683855
104Measles_Homo sapiens_hsa051620.37956253
105Basal transcription factors_Homo sapiens_hsa030220.37930429
106mRNA surveillance pathway_Homo sapiens_hsa030150.37456115
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37127172
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.36955992
109Cardiac muscle contraction_Homo sapiens_hsa042600.36939679
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.36884372
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36591485
112Tyrosine metabolism_Homo sapiens_hsa003500.36207040
113Asthma_Homo sapiens_hsa053100.35666423
114HTLV-I infection_Homo sapiens_hsa051660.35014965
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34704840
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.34235210
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33301507
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33191124
119Fat digestion and absorption_Homo sapiens_hsa049750.32418748
120Vitamin B6 metabolism_Homo sapiens_hsa007500.32029462
121Chemical carcinogenesis_Homo sapiens_hsa052040.31586676
122Bladder cancer_Homo sapiens_hsa052190.31142063
123Alcoholism_Homo sapiens_hsa050340.31098393
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28805563
125Hematopoietic cell lineage_Homo sapiens_hsa046400.28684475
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27297063
127Olfactory transduction_Homo sapiens_hsa047400.25392650
128Linoleic acid metabolism_Homo sapiens_hsa005910.25252258
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24104637
130Oocyte meiosis_Homo sapiens_hsa041140.23279634
131Phenylalanine metabolism_Homo sapiens_hsa003600.21373980
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21036623

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