RBFOX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85149530
2vocalization behavior (GO:0071625)5.79576779
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63309675
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54414933
5synaptic vesicle exocytosis (GO:0016079)5.41873938
6locomotory exploration behavior (GO:0035641)5.36092161
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31447417
8neuronal action potential propagation (GO:0019227)5.27100155
9synaptic vesicle maturation (GO:0016188)5.20405600
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.16462002
11regulation of glutamate receptor signaling pathway (GO:1900449)5.04361330
12glutamate secretion (GO:0014047)4.97868167
13protein localization to synapse (GO:0035418)4.90476797
14glutamate receptor signaling pathway (GO:0007215)4.85281762
15regulation of synaptic vesicle exocytosis (GO:2000300)4.68937399
16neuron cell-cell adhesion (GO:0007158)4.67244336
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52858284
18synaptic transmission, glutamatergic (GO:0035249)4.45977569
19exploration behavior (GO:0035640)4.45343870
20regulation of neuronal synaptic plasticity (GO:0048168)4.37391276
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.35224947
22neurotransmitter secretion (GO:0007269)4.34586750
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.30604203
24neuron-neuron synaptic transmission (GO:0007270)4.30239465
25regulation of synaptic vesicle transport (GO:1902803)4.22069616
26central nervous system myelination (GO:0022010)4.20112497
27axon ensheathment in central nervous system (GO:0032291)4.20112497
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.16590836
29dendritic spine morphogenesis (GO:0060997)4.10263915
30long-term memory (GO:0007616)4.09575502
31gamma-aminobutyric acid signaling pathway (GO:0007214)4.07112545
32layer formation in cerebral cortex (GO:0021819)4.00776935
33gamma-aminobutyric acid transport (GO:0015812)3.99615380
34regulation of postsynaptic membrane potential (GO:0060078)3.96205680
35positive regulation of synapse maturation (GO:0090129)3.94427891
36L-amino acid import (GO:0043092)3.92140293
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92123410
38regulation of synapse structural plasticity (GO:0051823)3.88544136
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.88505514
40neuron recognition (GO:0008038)3.86121385
41regulation of dendritic spine morphogenesis (GO:0061001)3.85554885
42positive regulation of membrane potential (GO:0045838)3.84033859
43neurotransmitter-gated ion channel clustering (GO:0072578)3.83066454
44cellular potassium ion homeostasis (GO:0030007)3.81492842
45potassium ion import (GO:0010107)3.80093690
46regulation of synaptic plasticity (GO:0048167)3.73649580
47neuronal ion channel clustering (GO:0045161)3.72057721
48transmission of nerve impulse (GO:0019226)3.67539697
49potassium ion homeostasis (GO:0055075)3.65282159
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63802343
51long-term synaptic potentiation (GO:0060291)3.63202164
52synaptic vesicle endocytosis (GO:0048488)3.62009717
53neuromuscular synaptic transmission (GO:0007274)3.61979987
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57588177
55neurotransmitter transport (GO:0006836)3.55669207
56serotonin metabolic process (GO:0042428)3.51360042
57cerebellar Purkinje cell differentiation (GO:0021702)3.50946158
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.49365999
59cerebellar granule cell differentiation (GO:0021707)3.48204530
60axonal fasciculation (GO:0007413)3.44469220
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.43660515
62regulation of neurotransmitter secretion (GO:0046928)3.41158113
63neurotransmitter uptake (GO:0001504)3.41033616
64membrane depolarization (GO:0051899)3.40132613
65regulation of vesicle fusion (GO:0031338)3.39616132
66behavioral fear response (GO:0001662)3.36637016
67behavioral defense response (GO:0002209)3.36637016
68positive regulation of neurotransmitter secretion (GO:0001956)3.34623331
69neuromuscular process controlling balance (GO:0050885)3.34285588
70regulation of dendritic spine development (GO:0060998)3.33967323
71presynaptic membrane assembly (GO:0097105)3.32780899
72regulation of neurotransmitter levels (GO:0001505)3.32545258
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32279970
74proline transport (GO:0015824)3.30801430
75presynaptic membrane organization (GO:0097090)3.28461903
76amino acid import (GO:0043090)3.28150943
77postsynaptic membrane organization (GO:0001941)3.27549035
78primary amino compound metabolic process (GO:1901160)3.27057271
79regulation of glutamate secretion (GO:0014048)3.26520840
80cell differentiation in hindbrain (GO:0021533)3.26496961
81positive regulation of dendritic spine development (GO:0060999)3.26463676
82fear response (GO:0042596)3.26085650
83dendritic spine organization (GO:0097061)3.25936902
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24515468
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24112220
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.23741062
87learning (GO:0007612)3.23151402
88behavioral response to cocaine (GO:0048148)3.21313520
89membrane depolarization during action potential (GO:0086010)3.20917662
90sodium ion export (GO:0071436)3.20676403
91regulation of calcium ion-dependent exocytosis (GO:0017158)3.20488364
92response to histamine (GO:0034776)3.19500716
93long term synaptic depression (GO:0060292)3.18696661
94neuromuscular process controlling posture (GO:0050884)3.16621724
95membrane hyperpolarization (GO:0060081)3.15695747
96cell communication by electrical coupling (GO:0010644)3.13978406
97activation of protein kinase A activity (GO:0034199)3.12713140
98regulation of neurotransmitter transport (GO:0051588)3.11747825
99positive regulation of neurotransmitter transport (GO:0051590)3.10210875
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09944761
101behavioral response to nicotine (GO:0035095)3.09723553
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09586861
103detection of calcium ion (GO:0005513)3.09310859
104acidic amino acid transport (GO:0015800)3.08388647
105regulation of synaptic transmission (GO:0050804)3.08304138
106cellular sodium ion homeostasis (GO:0006883)3.07847751
107regulation of voltage-gated calcium channel activity (GO:1901385)3.07494340
108establishment of synaptic vesicle localization (GO:0097480)3.07447894
109synaptic vesicle transport (GO:0048489)3.07447894
110response to auditory stimulus (GO:0010996)3.06980815
111chemosensory behavior (GO:0007635)3.06858965
112regulation of synapse maturation (GO:0090128)3.06015238
113synaptic transmission (GO:0007268)3.05147591
114social behavior (GO:0035176)3.04744193
115intraspecies interaction between organisms (GO:0051703)3.04744193
116acid secretion (GO:0046717)3.04070056
117auditory behavior (GO:0031223)3.03948939
118innervation (GO:0060384)3.03856732
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03805641
120potassium ion transmembrane transport (GO:0071805)3.03372222
121cellular potassium ion transport (GO:0071804)3.03372222
122mating behavior (GO:0007617)3.00548982
123synapse assembly (GO:0007416)2.99956331
124adult walking behavior (GO:0007628)2.99795987
125positive regulation of synaptic transmission (GO:0050806)2.99315868
126regulation of exocytosis (GO:0017157)2.98670445
127signal release (GO:0023061)2.98252021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.71822699
2GBX2_23144817_ChIP-Seq_PC3_Human3.60943257
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.30652705
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.29741400
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.24988299
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90135668
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90135668
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.79950522
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79625034
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.79392740
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66237073
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64277286
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.61459294
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61400103
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.59689221
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54078204
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.44063908
18DROSHA_22980978_ChIP-Seq_HELA_Human2.37142373
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.31206309
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30830153
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30730468
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.26524075
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.23004993
24TAF15_26573619_Chip-Seq_HEK293_Human1.95488805
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93374044
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91516268
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88598903
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87635413
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81154413
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80290875
31AR_21572438_ChIP-Seq_LNCaP_Human1.77196757
32SMAD4_21799915_ChIP-Seq_A2780_Human1.68098050
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67757248
34* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66876963
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.63482912
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61597897
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55239175
38ZNF274_21170338_ChIP-Seq_K562_Hela1.50577412
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47934568
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45285267
41P300_19829295_ChIP-Seq_ESCs_Human1.45263410
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40936982
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.33612265
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33137628
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32289073
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32274284
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.31576492
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.30931630
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28815930
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26675894
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.26116435
52AR_25329375_ChIP-Seq_VCAP_Human1.25486669
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22357392
54* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21882660
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18592314
56STAT3_23295773_ChIP-Seq_U87_Human1.16068623
57AR_19668381_ChIP-Seq_PC3_Human1.15438681
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.13936081
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13687802
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.13619442
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12838144
62VDR_22108803_ChIP-Seq_LS180_Human1.12663850
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12652764
64RNF2_27304074_Chip-Seq_NSC_Mouse1.12242258
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11546125
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.11362754
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10051046
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09273909
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09257461
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06791945
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05379218
72IGF1R_20145208_ChIP-Seq_DFB_Human1.05119264
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04983527
74TCF4_23295773_ChIP-Seq_U87_Human1.03595017
75CTCF_27219007_Chip-Seq_Bcells_Human1.03452420
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.03171705
77TP53_16413492_ChIP-PET_HCT116_Human1.02860622
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02333163
79FUS_26573619_Chip-Seq_HEK293_Human1.01748322
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.01483531
81RUNX2_22187159_ChIP-Seq_PCA_Human1.00425917
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98433729
83* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97550245
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97167555
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96708639
86AHR_22903824_ChIP-Seq_MCF-7_Human0.96377386
87OCT4_19829295_ChIP-Seq_ESCs_Human0.93589762
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93539156
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93539156
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93254001
91BCAT_22108803_ChIP-Seq_LS180_Human0.92859574
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92516868
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92248085
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92145064
95KDM2B_26808549_Chip-Seq_K562_Human0.91439037
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.91181135
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90289214
98JUN_21703547_ChIP-Seq_K562_Human0.89921680
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88600909
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88502393
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87404702
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87324333
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.86637539
104TP53_18474530_ChIP-ChIP_U2OS_Human0.86189642
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85992187
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.85517087
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.85509661
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.85374534
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82698141
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80885789
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80864149
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80478346
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.80357527
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80219693
115SMAD4_21741376_ChIP-Seq_EPCs_Human0.78852218
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78174390
117KLF4_19829295_ChIP-Seq_ESCs_Human0.77844773
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.76179140
119KDM2B_26808549_Chip-Seq_REH_Human0.75613239
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75491823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.52748688
2MP0003880_abnormal_central_pattern5.31157244
3MP0003635_abnormal_synaptic_transmissio4.28752237
4MP0004270_analgesia3.72840480
5MP0009745_abnormal_behavioral_response3.58676465
6MP0002063_abnormal_learning/memory/cond3.41588633
7MP0001968_abnormal_touch/_nociception3.37589819
8MP0009046_muscle_twitch3.31116894
9MP0002064_seizures3.25721422
10MP0002572_abnormal_emotion/affect_behav2.90779659
11MP0002272_abnormal_nervous_system2.80473589
12MP0002736_abnormal_nociception_after2.73762452
13MP0002734_abnormal_mechanical_nocicepti2.68244018
14MP0002735_abnormal_chemical_nociception2.65862202
15MP0001486_abnormal_startle_reflex2.55180487
16MP0005423_abnormal_somatic_nervous2.53556852
17MP0001501_abnormal_sleep_pattern2.42965582
18MP0002822_catalepsy2.41860238
19MP0001440_abnormal_grooming_behavior2.37906605
20MP0002733_abnormal_thermal_nociception2.17408937
21MP0002067_abnormal_sensory_capabilities2.13806406
22MP0001970_abnormal_pain_threshold2.07034719
23MP0002184_abnormal_innervation1.98953767
24MP0008569_lethality_at_weaning1.97447467
25MP0003329_amyloid_beta_deposits1.95682305
26MP0006276_abnormal_autonomic_nervous1.86940147
27MP0000778_abnormal_nervous_system1.81422764
28MP0002557_abnormal_social/conspecific_i1.75549546
29MP0005386_behavior/neurological_phenoty1.75017351
30MP0004924_abnormal_behavior1.75017351
31MP0008877_abnormal_DNA_methylation1.68488864
32MP0004811_abnormal_neuron_physiology1.66055371
33MP0003879_abnormal_hair_cell1.61381223
34MP0001984_abnormal_olfaction1.59282786
35MP0004858_abnormal_nervous_system1.58943310
36MP0000955_abnormal_spinal_cord1.52268650
37MP0009780_abnormal_chondrocyte_physiolo1.51591271
38MP0004145_abnormal_muscle_electrophysio1.51581066
39MP0001529_abnormal_vocalization1.50723827
40MP0002909_abnormal_adrenal_gland1.50144114
41MP0002066_abnormal_motor_capabilities/c1.45083354
42MP0001986_abnormal_taste_sensitivity1.39717932
43MP0002882_abnormal_neuron_morphology1.38337963
44MP0004147_increased_porphyrin_level1.34638825
45MP0001188_hyperpigmentation1.34585437
46MP0004142_abnormal_muscle_tone1.30067922
47MP0005646_abnormal_pituitary_gland1.29319989
48MP0001905_abnormal_dopamine_level1.28543730
49MP0004885_abnormal_endolymph1.27711152
50MP0003633_abnormal_nervous_system1.25489458
51MP0002837_dystrophic_cardiac_calcinosis1.18702763
52MP0003123_paternal_imprinting1.18277353
53MP0001502_abnormal_circadian_rhythm1.16946944
54MP0003787_abnormal_imprinting1.16144177
55MP0003631_nervous_system_phenotype1.10156244
56MP0002152_abnormal_brain_morphology1.08713552
57MP0005645_abnormal_hypothalamus_physiol1.07295397
58MP0004742_abnormal_vestibular_system1.05138143
59MP0010386_abnormal_urinary_bladder1.04653713
60MP0008872_abnormal_physiological_respon1.04109243
61MP0000751_myopathy0.96743941
62MP0008874_decreased_physiological_sensi0.94619104
63MP0002069_abnormal_eating/drinking_beha0.93370290
64MP0002229_neurodegeneration0.92589308
65MP0003122_maternal_imprinting0.90636620
66MP0000604_amyloidosis0.88722703
67MP0004484_altered_response_of0.87085732
68MP0001963_abnormal_hearing_physiology0.86889185
69MP0005535_abnormal_body_temperature0.86259705
70MP0005409_darkened_coat_color0.85917243
71MP0000013_abnormal_adipose_tissue0.85404510
72MP0004085_abnormal_heartbeat0.83107615
73MP0003632_abnormal_nervous_system0.82383966
74MP0005551_abnormal_eye_electrophysiolog0.81609589
75MP0006292_abnormal_olfactory_placode0.79245443
76MP0004130_abnormal_muscle_cell0.78592213
77MP0002752_abnormal_somatic_nervous0.76399733
78MP0006072_abnormal_retinal_apoptosis0.76113337
79MP0005394_taste/olfaction_phenotype0.76004563
80MP0005499_abnormal_olfactory_system0.76004563
81MP0003121_genomic_imprinting0.75678731
82MP0004215_abnormal_myocardial_fiber0.74443164
83MP0004043_abnormal_pH_regulation0.74102775
84MP0001177_atelectasis0.73783683
85MP0000920_abnormal_myelination0.73484955
86MP0003075_altered_response_to0.69807028
87MP0003634_abnormal_glial_cell0.69754062
88MP0001485_abnormal_pinna_reflex0.69229893
89MP0004510_myositis0.68681337
90MP0002876_abnormal_thyroid_physiology0.68572398
91MP0005253_abnormal_eye_physiology0.64404897
92MP0000631_abnormal_neuroendocrine_gland0.63800126
93MP0001664_abnormal_digestion0.63378677
94MP0003690_abnormal_glial_cell0.61146013
95MP0003137_abnormal_impulse_conducting0.60741636
96MP0004133_heterotaxia0.60597203
97MP0002102_abnormal_ear_morphology0.60284972
98MP0002653_abnormal_ependyma_morphology0.59848921
99MP0001346_abnormal_lacrimal_gland0.59051310
100MP0008961_abnormal_basal_metabolism0.58229392
101MP0001765_abnormal_ion_homeostasis0.57686878
102MP0000569_abnormal_digit_pigmentation0.56522893
103MP0003938_abnormal_ear_development0.55321777
104MP0001943_abnormal_respiration0.54992497
105MP0005187_abnormal_penis_morphology0.54678782
106MP0000026_abnormal_inner_ear0.54524742
107MP0003861_abnormal_nervous_system0.54485288
108MP0001348_abnormal_lacrimal_gland0.54168404
109MP0002638_abnormal_pupillary_reflex0.53833009
110MP0002090_abnormal_vision0.52422376
111MP0004233_abnormal_muscle_weight0.52365033
112MP0010234_abnormal_vibrissa_follicle0.52100551
113MP0010769_abnormal_survival0.50926585
114MP0003646_muscle_fatigue0.49793267
115MP0010770_preweaning_lethality0.49219141
116MP0002082_postnatal_lethality0.49219141
117MP0003956_abnormal_body_size0.49171740
118MP0003283_abnormal_digestive_organ0.48795011
119MP0005167_abnormal_blood-brain_barrier0.48321702
120MP0000639_abnormal_adrenal_gland0.46373877

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.42401879
2Myokymia (HP:0002411)6.76163764
3Focal seizures (HP:0007359)6.31063237
4Visual hallucinations (HP:0002367)5.69467312
5Atonic seizures (HP:0010819)5.32739691
6Epileptic encephalopathy (HP:0200134)5.18447818
7Febrile seizures (HP:0002373)4.83030123
8Progressive cerebellar ataxia (HP:0002073)4.80954206
9Absence seizures (HP:0002121)4.66393639
10Action tremor (HP:0002345)4.34415161
11Dialeptic seizures (HP:0011146)4.32899590
12Generalized tonic-clonic seizures (HP:0002069)4.02649020
13Broad-based gait (HP:0002136)3.95790370
14Hyperventilation (HP:0002883)3.92947169
15Gaze-evoked nystagmus (HP:0000640)3.82539574
16Poor eye contact (HP:0000817)3.61888775
17Amblyopia (HP:0000646)3.60565343
18Cerebral hypomyelination (HP:0006808)3.57386789
19Supranuclear gaze palsy (HP:0000605)3.48174515
20Dysdiadochokinesis (HP:0002075)3.44904764
21Truncal ataxia (HP:0002078)3.34247704
22Dysmetria (HP:0001310)3.32884929
23Impaired social interactions (HP:0000735)3.21875339
24Abnormal social behavior (HP:0012433)3.21875339
25Anxiety (HP:0000739)3.21080959
26Impaired vibration sensation in the lower limbs (HP:0002166)3.14475971
27Depression (HP:0000716)3.05006305
28Scanning speech (HP:0002168)2.99862535
29Impaired smooth pursuit (HP:0007772)2.97467356
30Cerebral inclusion bodies (HP:0100314)2.96297097
31Hemiparesis (HP:0001269)2.92758404
32Abnormal eating behavior (HP:0100738)2.83522364
33Abnormality of binocular vision (HP:0011514)2.81826108
34Diplopia (HP:0000651)2.81826108
35Ankle clonus (HP:0011448)2.76937924
36Urinary bladder sphincter dysfunction (HP:0002839)2.75477322
37Drooling (HP:0002307)2.75405781
38Excessive salivation (HP:0003781)2.75405781
39Abnormality of the lower motor neuron (HP:0002366)2.72630600
40Tetraplegia (HP:0002445)2.70410778
41Genetic anticipation (HP:0003743)2.69889494
42Neurofibrillary tangles (HP:0002185)2.68971302
43Akinesia (HP:0002304)2.66191870
44Status epilepticus (HP:0002133)2.61766864
45Epileptiform EEG discharges (HP:0011182)2.60355559
46Mutism (HP:0002300)2.59153918
47Stereotypic behavior (HP:0000733)2.56480071
48Abnormality of ocular smooth pursuit (HP:0000617)2.53896391
49Absent speech (HP:0001344)2.53895016
50Progressive inability to walk (HP:0002505)2.53693755
51Dysmetric saccades (HP:0000641)2.52606846
52Postural instability (HP:0002172)2.50499480
53EEG with generalized epileptiform discharges (HP:0011198)2.45780885
54Intention tremor (HP:0002080)2.45568370
55Termporal pattern (HP:0011008)2.42316790
56Insidious onset (HP:0003587)2.42316790
57Urinary urgency (HP:0000012)2.41253849
58Spastic gait (HP:0002064)2.38987003
59CNS hypomyelination (HP:0003429)2.35861190
60Hemiplegia (HP:0002301)2.35328055
61Delusions (HP:0000746)2.34540698
62Annular pancreas (HP:0001734)2.34521545
63Inability to walk (HP:0002540)2.33191824
64Bradykinesia (HP:0002067)2.28953294
65Hypsarrhythmia (HP:0002521)2.27616441
66Abnormality of the corticospinal tract (HP:0002492)2.25196399
67Morphological abnormality of the pyramidal tract (HP:0002062)2.23860081
68Torticollis (HP:0000473)2.21917133
69Clonus (HP:0002169)2.20726634
70Papilledema (HP:0001085)2.20199618
71Focal dystonia (HP:0004373)2.19161818
72Sleep apnea (HP:0010535)2.18950825
73Generalized myoclonic seizures (HP:0002123)2.17767534
74Congenital stationary night blindness (HP:0007642)2.15984665
75Lower limb asymmetry (HP:0100559)2.15467599
76Fetal akinesia sequence (HP:0001989)2.14864681
77Choreoathetosis (HP:0001266)2.14799244
78Confusion (HP:0001289)2.11488004
79Impaired vibratory sensation (HP:0002495)2.10351809
80Gait ataxia (HP:0002066)2.07817214
81Psychosis (HP:0000709)2.06698055
82Spastic tetraparesis (HP:0001285)2.06035071
83Ventricular fibrillation (HP:0001663)2.04252279
84Megalencephaly (HP:0001355)2.03638972
85Incomplete penetrance (HP:0003829)2.01703817
86Increased circulating renin level (HP:0000848)2.01355599
87Protruding tongue (HP:0010808)1.98628196
88Decreased central vision (HP:0007663)1.98626543
89Amyotrophic lateral sclerosis (HP:0007354)1.93694657
90Limb dystonia (HP:0002451)1.93585732
91Pheochromocytoma (HP:0002666)1.92736280
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91369234
93Agitation (HP:0000713)1.91049058
94Polyphagia (HP:0002591)1.89627505
95Prolonged QT interval (HP:0001657)1.89499435
96Lower limb muscle weakness (HP:0007340)1.89490268
97Craniofacial dystonia (HP:0012179)1.88543159
98Neuronal loss in central nervous system (HP:0002529)1.87924730
99Dyskinesia (HP:0100660)1.87820729
100Abnormality of salivation (HP:0100755)1.86798293
101Pointed chin (HP:0000307)1.86255619
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83183599
103Rapidly progressive (HP:0003678)1.82569768
104Abnormal EKG (HP:0003115)1.80252248
105Blue irides (HP:0000635)1.79102964
106Abnormality of saccadic eye movements (HP:0000570)1.78547308
107Metabolic alkalosis (HP:0200114)1.78130929
108Unsteady gait (HP:0002317)1.75978540
109Obstructive sleep apnea (HP:0002870)1.75658841
110Spastic tetraplegia (HP:0002510)1.75351151
111Retinal dysplasia (HP:0007973)1.72434727
112Rigidity (HP:0002063)1.72082747
113Spinal canal stenosis (HP:0003416)1.71689504
114Limb ataxia (HP:0002070)1.71419080
115Thickened helices (HP:0000391)1.69762711
116Polydipsia (HP:0001959)1.69289988
117Abnormal drinking behavior (HP:0030082)1.69289988
118Inappropriate behavior (HP:0000719)1.69270847
119Progressive microcephaly (HP:0000253)1.68629799
120Bundle branch block (HP:0011710)1.68111120
121Hyperthyroidism (HP:0000836)1.67031770
122Specific learning disability (HP:0001328)1.66498213
123Autism (HP:0000717)1.66050457
124Neuroendocrine neoplasm (HP:0100634)1.65308076
125Horizontal nystagmus (HP:0000666)1.63385513
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.62885565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.88443673
2NTRK34.64867845
3MAP3K93.59017277
4RIPK43.28902842
5MAP3K43.01279186
6MINK12.72061337
7MAP2K72.58709554
8DAPK22.53690289
9MAP3K122.45727480
10PNCK2.22184861
11MARK12.19662818
12KSR22.18413977
13PAK62.08193609
14MAP2K42.05728496
15CASK2.01022207
16ARAF1.79163293
17PLK21.77784738
18NTRK21.75357445
19KSR11.74073631
20NTRK11.72555804
21DAPK11.70708722
22FRK1.65653718
23GRK51.61832600
24CAMKK11.60627941
25SIK21.59750441
26TNIK1.49576844
27CDK51.48156133
28CDK191.43468805
29MAP3K131.42162085
30BMPR21.38719228
31CAMKK21.34639034
32PRKD31.34068511
33FES1.33358860
34PRKCG1.27774596
35STK381.24495012
36PRPF4B1.18162370
37MAPK131.17736945
38PTK2B1.15509863
39MAP4K21.06369482
40CAMK2A1.05594405
41MAP3K21.03432551
42ADRBK21.01897595
43RAF11.01181961
44UHMK10.99228842
45NME10.97994888
46PKN10.93232459
47TYRO30.91133992
48CAMK2B0.90985704
49WNK40.89116271
50CAMK10.87509730
51FGFR20.86648496
52CDK180.85772440
53CDK140.83525904
54CDK150.82920386
55GRK10.82062607
56OXSR10.81890308
57NEK60.79881691
58TAOK30.78676285
59FGR0.77601478
60STK110.76191226
61SGK2230.74847253
62SGK4940.74847253
63LATS20.73875966
64LIMK10.73004569
65CDK11A0.72780747
66PINK10.72259699
67MAP2K60.69893310
68RET0.69679434
69DYRK1A0.68776858
70SGK10.65377371
71INSRR0.61877163
72TLK10.61274185
73RIPK10.60613637
74PHKG10.59868368
75PHKG20.59868368
76PAK30.59737036
77SGK20.59678361
78CCNB10.59024089
79TNK20.58702880
80MAP3K10.58598807
81PDPK10.57621196
82PDK10.56470565
83MARK20.56308998
84TXK0.55625535
85TAOK10.55574206
86STK390.54912081
87PRKCE0.54329520
88MAPKAPK50.53866503
89PRKCH0.53594104
90CAMK2D0.53493506
91FER0.52609424
92CAMK2G0.50733809
93CAMK1G0.49518963
94BRSK10.49041596
95SIK30.49038560
96PRKCA0.48631255
97MAP2K10.48003143
98ROCK20.47505406
99PRKCZ0.46476654
100WNK10.46044919
101DAPK30.44588498
102CSNK1G20.43800273
103LMTK20.43614427
104DYRK20.41929872
105ERBB20.41274776
106BRAF0.41132564
107FYN0.40985674
108RPS6KA30.40912970
109SGK30.40778239
110CAMK40.38262513
111MUSK0.37259789
112MAPK100.36605702
113MAP3K110.36271526
114MAPK120.35007494
115WNK30.34979119
116MAP3K60.34904631
117PRKG20.34238612
118GRK70.33584579
119MAP2K20.33520793
120CSNK1A10.33251400
121CSNK1D0.32181830
122PRKG10.32063961
123BCR0.31999556
124PRKACA0.31830720
125ALK0.31813230
126ADRBK10.31112516
127CDC42BPA0.30475155
128GRK60.30233533

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.05493045
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15168414
3Long-term potentiation_Homo sapiens_hsa047203.04248251
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85274538
5Glutamatergic synapse_Homo sapiens_hsa047242.75253317
6Circadian entrainment_Homo sapiens_hsa047132.72534329
7GABAergic synapse_Homo sapiens_hsa047272.63863307
8Olfactory transduction_Homo sapiens_hsa047402.62052719
9Amphetamine addiction_Homo sapiens_hsa050312.60896733
10Morphine addiction_Homo sapiens_hsa050322.49756218
11Salivary secretion_Homo sapiens_hsa049702.32752849
12Dopaminergic synapse_Homo sapiens_hsa047282.19461592
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18315563
14Taste transduction_Homo sapiens_hsa047422.06415949
15Long-term depression_Homo sapiens_hsa047301.95538087
16Gastric acid secretion_Homo sapiens_hsa049711.94895360
17Insulin secretion_Homo sapiens_hsa049111.88059128
18Renin secretion_Homo sapiens_hsa049241.87283514
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84420985
20Cholinergic synapse_Homo sapiens_hsa047251.83945851
21Oxytocin signaling pathway_Homo sapiens_hsa049211.76769306
22Serotonergic synapse_Homo sapiens_hsa047261.72772147
23Calcium signaling pathway_Homo sapiens_hsa040201.72670223
24Collecting duct acid secretion_Homo sapiens_hsa049661.68364635
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65411976
26GnRH signaling pathway_Homo sapiens_hsa049121.50783132
27Cocaine addiction_Homo sapiens_hsa050301.48339489
28Vitamin B6 metabolism_Homo sapiens_hsa007501.41380375
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38516232
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36420852
31Gap junction_Homo sapiens_hsa045401.35120111
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31450175
33Cardiac muscle contraction_Homo sapiens_hsa042601.31213506
34cAMP signaling pathway_Homo sapiens_hsa040241.25242018
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21090982
36Estrogen signaling pathway_Homo sapiens_hsa049151.16161949
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11134933
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11103289
39Glioma_Homo sapiens_hsa052141.09061137
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08176235
41Axon guidance_Homo sapiens_hsa043601.07304927
42Melanogenesis_Homo sapiens_hsa049161.07258439
43Type II diabetes mellitus_Homo sapiens_hsa049301.02169017
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01013060
45Alzheimers disease_Homo sapiens_hsa050101.00811507
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96437102
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.95511549
48Vibrio cholerae infection_Homo sapiens_hsa051100.94180029
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93578408
50Pancreatic secretion_Homo sapiens_hsa049720.93432364
51ErbB signaling pathway_Homo sapiens_hsa040120.93083126
52Phototransduction_Homo sapiens_hsa047440.92815116
53Oocyte meiosis_Homo sapiens_hsa041140.92022703
54Oxidative phosphorylation_Homo sapiens_hsa001900.90856718
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83042838
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.78529965
57Thyroid hormone synthesis_Homo sapiens_hsa049180.78235266
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75393483
59VEGF signaling pathway_Homo sapiens_hsa043700.75343958
60Dorso-ventral axis formation_Homo sapiens_hsa043200.73679168
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73377868
62Choline metabolism in cancer_Homo sapiens_hsa052310.72959135
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69454161
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68539255
65MAPK signaling pathway_Homo sapiens_hsa040100.67536384
66Parkinsons disease_Homo sapiens_hsa050120.64539026
67Dilated cardiomyopathy_Homo sapiens_hsa054140.63681116
68Glucagon signaling pathway_Homo sapiens_hsa049220.60122555
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60020158
70African trypanosomiasis_Homo sapiens_hsa051430.59772887
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56362901
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.55269979
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54694602
74Ether lipid metabolism_Homo sapiens_hsa005650.52770161
75Histidine metabolism_Homo sapiens_hsa003400.52581880
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.52203437
77Rap1 signaling pathway_Homo sapiens_hsa040150.52144453
78Ras signaling pathway_Homo sapiens_hsa040140.51863082
79Butanoate metabolism_Homo sapiens_hsa006500.51771052
80Arginine and proline metabolism_Homo sapiens_hsa003300.51420051
81Inositol phosphate metabolism_Homo sapiens_hsa005620.49966561
82Linoleic acid metabolism_Homo sapiens_hsa005910.49210930
83Ovarian steroidogenesis_Homo sapiens_hsa049130.47026285
84Huntingtons disease_Homo sapiens_hsa050160.46468122
85Mineral absorption_Homo sapiens_hsa049780.46212505
86Type I diabetes mellitus_Homo sapiens_hsa049400.44177369
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43862482
88Alcoholism_Homo sapiens_hsa050340.43275783
89beta-Alanine metabolism_Homo sapiens_hsa004100.42189842
90Regulation of autophagy_Homo sapiens_hsa041400.41978047
91Wnt signaling pathway_Homo sapiens_hsa043100.39570660
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39320807
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39257448
94mTOR signaling pathway_Homo sapiens_hsa041500.38461370
95Prion diseases_Homo sapiens_hsa050200.38023395
96Nitrogen metabolism_Homo sapiens_hsa009100.37775101
97Bile secretion_Homo sapiens_hsa049760.37491147
98Non-small cell lung cancer_Homo sapiens_hsa052230.35705523
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35503776
100ABC transporters_Homo sapiens_hsa020100.34506254
101Circadian rhythm_Homo sapiens_hsa047100.33086241
102Endocytosis_Homo sapiens_hsa041440.32659103
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31277617
104Renal cell carcinoma_Homo sapiens_hsa052110.30474628
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28442113
106Fatty acid biosynthesis_Homo sapiens_hsa000610.28356864
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27393072
108Insulin signaling pathway_Homo sapiens_hsa049100.27349693
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26965362
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25609865
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24691267
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24608434
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24123488
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24027930
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23101022
116Chemokine signaling pathway_Homo sapiens_hsa040620.22990534
117Endometrial cancer_Homo sapiens_hsa052130.22729115
118Tryptophan metabolism_Homo sapiens_hsa003800.22099468
119Rheumatoid arthritis_Homo sapiens_hsa053230.21963828
120Glycerolipid metabolism_Homo sapiens_hsa005610.21411752
121Arginine biosynthesis_Homo sapiens_hsa002200.20888396
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.20519415

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