RBKS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.32965450
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.32965450
3positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.31820838
4positive regulation of heat generation (GO:0031652)4.28396291
5L-phenylalanine metabolic process (GO:0006558)4.16427640
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.16427640
7cilium or flagellum-dependent cell motility (GO:0001539)4.11420666
8disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.09342621
9killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.09342621
10aromatic amino acid family catabolic process (GO:0009074)4.02233155
11axonemal dynein complex assembly (GO:0070286)3.85152036
12tryptophan catabolic process (GO:0006569)3.69670202
13indole-containing compound catabolic process (GO:0042436)3.69670202
14indolalkylamine catabolic process (GO:0046218)3.69670202
15killing of cells of other organism (GO:0031640)3.66630898
16disruption of cells of other organism (GO:0044364)3.66630898
17glyoxylate metabolic process (GO:0046487)3.64495607
18ribosomal small subunit assembly (GO:0000028)3.51111766
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50681708
20low-density lipoprotein particle remodeling (GO:0034374)3.49201322
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.48904543
22tryptophan metabolic process (GO:0006568)3.48466032
23regulation of heterotypic cell-cell adhesion (GO:0034114)3.47429518
24epithelial cilium movement (GO:0003351)3.43472653
25regulation of fever generation (GO:0031620)3.40403466
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31365243
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31365243
28kynurenine metabolic process (GO:0070189)3.29951258
29epoxygenase P450 pathway (GO:0019373)3.29108730
30regulation of heat generation (GO:0031650)3.28843628
31bile acid biosynthetic process (GO:0006699)3.28196328
32regulation of cytokine secretion involved in immune response (GO:0002739)3.26686219
33cysteine metabolic process (GO:0006534)3.24985708
34cilium movement (GO:0003341)3.23464918
35signal peptide processing (GO:0006465)3.23091425
36drug catabolic process (GO:0042737)3.21723145
37sulfur amino acid catabolic process (GO:0000098)3.18321366
38regulation of vitamin D biosynthetic process (GO:0060556)3.17562195
39serine family amino acid biosynthetic process (GO:0009070)3.16184527
40regulation of cholesterol esterification (GO:0010872)3.13542483
41DNA deamination (GO:0045006)3.12742006
42plasma lipoprotein particle remodeling (GO:0034369)3.12473388
43protein-lipid complex remodeling (GO:0034368)3.12473388
44macromolecular complex remodeling (GO:0034367)3.12473388
45high-density lipoprotein particle remodeling (GO:0034375)3.12122878
46alpha-linolenic acid metabolic process (GO:0036109)3.08759385
47motile cilium assembly (GO:0044458)3.08574597
48urea cycle (GO:0000050)3.07958303
49urea metabolic process (GO:0019627)3.07958303
50piRNA metabolic process (GO:0034587)3.02936588
51negative regulation of lipid storage (GO:0010888)3.02037147
52antigen processing and presentation of endogenous antigen (GO:0019883)3.01361591
53complement activation, alternative pathway (GO:0006957)3.01116073
54neutrophil mediated immunity (GO:0002446)3.00296634
55regulation of vitamin metabolic process (GO:0030656)3.00150317
56exogenous drug catabolic process (GO:0042738)2.99106431
57heme metabolic process (GO:0042168)2.95534542
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94775050
59lysine catabolic process (GO:0006554)2.93707232
60lysine metabolic process (GO:0006553)2.93707232
61nitrogen cycle metabolic process (GO:0071941)2.93326494
62phospholipid efflux (GO:0033700)2.92769800
63cofactor catabolic process (GO:0051187)2.90159434
64negative regulation of interleukin-1 beta production (GO:0032691)2.89761213
65regulation of triglyceride catabolic process (GO:0010896)2.89139961
66aromatic amino acid family metabolic process (GO:0009072)2.88776771
67regulation of interleukin-8 biosynthetic process (GO:0045414)2.87774235
68ethanol oxidation (GO:0006069)2.86545788
69positive regulation of B cell differentiation (GO:0045579)2.86152659
70branching involved in labyrinthine layer morphogenesis (GO:0060670)2.84201279
71NAD biosynthetic process (GO:0009435)2.83514050
72positive regulation of fatty acid biosynthetic process (GO:0045723)2.83107959
73regulation of chronic inflammatory response (GO:0002676)2.82829327
74glutathione derivative biosynthetic process (GO:1901687)2.82028171
75glutathione derivative metabolic process (GO:1901685)2.82028171
76phenylpropanoid metabolic process (GO:0009698)2.81713072
77axoneme assembly (GO:0035082)2.81443603
78valine metabolic process (GO:0006573)2.81070835
79amyloid precursor protein catabolic process (GO:0042987)2.79534985
80regulation of protein activation cascade (GO:2000257)2.79265311
81L-serine metabolic process (GO:0006563)2.77974282
82regulation of fibrinolysis (GO:0051917)2.77780754
83positive regulation of acute inflammatory response (GO:0002675)2.77683218
84glycine metabolic process (GO:0006544)2.77266812
85reactive oxygen species biosynthetic process (GO:1903409)2.76802490
86heme biosynthetic process (GO:0006783)2.76544815
87aldehyde catabolic process (GO:0046185)2.76497935
88primary alcohol catabolic process (GO:0034310)2.73677530
89omega-hydroxylase P450 pathway (GO:0097267)2.72125142
90positive regulation of triglyceride lipase activity (GO:0061365)2.71274739
91positive regulation of lipoprotein lipase activity (GO:0051006)2.71274739
92positive regulation of prostaglandin secretion (GO:0032308)2.70773582
93serine family amino acid metabolic process (GO:0009069)2.70549181
94protoporphyrinogen IX biosynthetic process (GO:0006782)2.70364114
95imidazole-containing compound metabolic process (GO:0052803)2.70186177
96amino-acid betaine metabolic process (GO:0006577)2.69693976
97respiratory burst (GO:0045730)2.69104285
98drug metabolic process (GO:0017144)2.68046809
99benzene-containing compound metabolic process (GO:0042537)2.67658964
100pyrimidine-containing compound transmembrane transport (GO:0072531)2.67480080
101negative regulation of fibrinolysis (GO:0051918)2.65431848
102neutrophil activation involved in immune response (GO:0002283)2.65153648
103negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.65027409
104modulation of growth of symbiont involved in interaction with host (GO:0044144)2.65027409
105regulation of growth of symbiont in host (GO:0044126)2.65027409
106negative regulation of growth of symbiont in host (GO:0044130)2.65027409
107bile acid metabolic process (GO:0008206)2.64887126
108nicotinamide nucleotide biosynthetic process (GO:0019359)2.64838367
109pyridine nucleotide biosynthetic process (GO:0019363)2.64838367
110regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64449151
111regulation of complement activation (GO:0030449)2.63307997
112cellular biogenic amine catabolic process (GO:0042402)2.63115690
113amine catabolic process (GO:0009310)2.63115690
114alkaloid metabolic process (GO:0009820)2.62252023
115negative regulation of sterol transport (GO:0032372)2.62033244
116negative regulation of cholesterol transport (GO:0032375)2.62033244
117regulation of interleukin-12 biosynthetic process (GO:0045075)2.60684831
118defense response to fungus (GO:0050832)2.59897525
119response to nitrosative stress (GO:0051409)2.58894189
120cholesterol efflux (GO:0033344)2.58866716
121reverse cholesterol transport (GO:0043691)2.58757091
122plasma lipoprotein particle assembly (GO:0034377)2.58695228
123positive regulation of chemokine biosynthetic process (GO:0045080)2.58240651
124response to peptidoglycan (GO:0032494)2.58191613
125T-helper 1 type immune response (GO:0042088)2.57731999
126regulation of chemokine biosynthetic process (GO:0045073)2.57555325
127cobalamin metabolic process (GO:0009235)2.56835284
128alpha-amino acid catabolic process (GO:1901606)2.56310202
129negative regulation of cytokine production involved in immune response (GO:0002719)2.56307642
130plasma lipoprotein particle organization (GO:0071827)2.56174765
131protoporphyrinogen IX metabolic process (GO:0046501)2.55829253
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55478039
133fibrinolysis (GO:0042730)2.54675737
134protein carboxylation (GO:0018214)2.54474345
135peptidyl-glutamic acid carboxylation (GO:0017187)2.54474345
136positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.52313876
137pyrimidine nucleoside salvage (GO:0043097)2.51548360
138pyrimidine-containing compound salvage (GO:0008655)2.51548360
139indolalkylamine metabolic process (GO:0006586)2.50490417
140coenzyme catabolic process (GO:0009109)2.50478377
141nucleoside salvage (GO:0043174)2.50202361
142xenobiotic catabolic process (GO:0042178)2.49896754
143acute-phase response (GO:0006953)2.49788945
144complement activation, classical pathway (GO:0006958)2.49473803
145glucose 6-phosphate metabolic process (GO:0051156)2.49449137
146negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.49103797
147tyrosine metabolic process (GO:0006570)2.48851481
148cellular response to ethanol (GO:0071361)2.48139785
149opsonization (GO:0008228)2.46889875
150regulation of immunoglobulin secretion (GO:0051023)2.44730015
151peroxisome fission (GO:0016559)2.42005828
152positive regulation of icosanoid secretion (GO:0032305)2.41882131
153positive regulation of fatty acid transport (GO:2000193)2.41587432
154cellular ketone body metabolic process (GO:0046950)2.37937912
155detection of light stimulus involved in visual perception (GO:0050908)2.36403034
156detection of light stimulus involved in sensory perception (GO:0050962)2.36403034
157positive regulation of nitric oxide biosynthetic process (GO:0045429)2.35854683
158negative regulation of interleukin-1 production (GO:0032692)2.35611647
159positive regulation of NF-kappaB import into nucleus (GO:0042346)2.35593279
160oligosaccharide catabolic process (GO:0009313)2.33921754
161fat-soluble vitamin biosynthetic process (GO:0042362)2.33744587
162regulation of interleukin-6 biosynthetic process (GO:0045408)2.30434359
163phospholipid homeostasis (GO:0055091)2.29531652
164regulation of acute inflammatory response (GO:0002673)2.27971090
165bile acid and bile salt transport (GO:0015721)2.26844935
166negative regulation of lipid catabolic process (GO:0050995)2.25700146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.97615660
2E2F7_22180533_ChIP-Seq_HELA_Human3.78195528
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.27099195
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.20126986
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.19484899
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07111856
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.98900873
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95903614
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72493047
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56377543
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49617248
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36396044
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.30954324
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29586321
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.28185954
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26707832
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17257838
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14323183
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11954391
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.08444811
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04103658
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98329690
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97702162
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96517780
25GATA1_22025678_ChIP-Seq_K562_Human1.95586912
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93937508
27SCL_19346495_ChIP-Seq_HPC-7_Human1.90205564
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83641489
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.83020420
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.81366708
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76381257
32IGF1R_20145208_ChIP-Seq_DFB_Human1.76032014
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75385593
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74230571
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74145833
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72290459
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70969008
38GBX2_23144817_ChIP-Seq_PC3_Human1.69918252
39* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67213938
40VDR_21846776_ChIP-Seq_THP-1_Human1.67062936
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64246352
42SPI1_23547873_ChIP-Seq_NB4_Human1.63874952
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.62238001
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59437759
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.58869689
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56919285
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56771973
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56545750
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56484165
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56255696
51ER_23166858_ChIP-Seq_MCF-7_Human1.56128113
52* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55605822
53VDR_23849224_ChIP-Seq_CD4+_Human1.55302418
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53702792
55FOXP3_21729870_ChIP-Seq_TREG_Human1.51869834
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.51682806
57VDR_22108803_ChIP-Seq_LS180_Human1.51534786
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49100536
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47243064
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44320522
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43975486
62CBP_20019798_ChIP-Seq_JUKART_Human1.38195832
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38195832
64DCP1A_22483619_ChIP-Seq_HELA_Human1.37971514
65ZNF274_21170338_ChIP-Seq_K562_Hela1.37857486
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36631497
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35369843
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35231507
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34749577
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.33858011
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32535956
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.32535956
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32324430
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32314136
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.31186005
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30550001
77MYB_26560356_Chip-Seq_TH2_Human1.30264796
78VDR_24763502_ChIP-Seq_THP-1_Human1.28204424
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28115170
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27947134
81MYC_22102868_ChIP-Seq_BL_Human1.27804399
82CDX2_22108803_ChIP-Seq_LS180_Human1.27562474
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27479593
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27223156
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26880371
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25698506
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24489925
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24293785
89GATA3_26560356_Chip-Seq_TH2_Human1.24028919
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23371152
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22420958
92GATA4_25053715_ChIP-Seq_YYC3_Human1.22136073
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22037766
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21842643
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21040853
96VDR_24787735_ChIP-Seq_THP-1_Human1.20998398
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19361694
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17972203
99BCAT_22108803_ChIP-Seq_LS180_Human1.17173304
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15657639
101MAF_26560356_Chip-Seq_TH1_Human1.14934783
102AR_20517297_ChIP-Seq_VCAP_Human1.14555208
103MYB_26560356_Chip-Seq_TH1_Human1.13895927
104GABP_19822575_ChIP-Seq_HepG2_Human1.13234215
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12864902
106STAT1_20625510_ChIP-Seq_HELA_Human1.12776045
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12412932
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10691704
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.10521537
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08526543
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08322665
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06875956
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06173164
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05165897
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.04989691
116SOX2_19829295_ChIP-Seq_ESCs_Human1.04986700
117NANOG_19829295_ChIP-Seq_ESCs_Human1.04986700
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.04628997
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04524506
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03793319
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03518801
122XRN2_22483619_ChIP-Seq_HELA_Human1.03246538
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03007994
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01358720
125HTT_18923047_ChIP-ChIP_STHdh_Human1.01140517
126* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00929784
127CEBPB_22108803_ChIP-Seq_LS180_Human1.00407113
128* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99982938
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.99305646
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99248421
131SMRT_27268052_Chip-Seq_Bcells_Human0.99163098
132* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99027670
133TCF4_22108803_ChIP-Seq_LS180_Human0.98398310
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97862101
135* SOX2_20726797_ChIP-Seq_SW620_Human0.97740976
136NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97391433
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97292844
138NCOR_22424771_ChIP-Seq_293T_Human0.97069592
139RUNX_20019798_ChIP-Seq_JUKART_Human0.96867813
140TP53_22573176_ChIP-Seq_HFKS_Human0.96036968
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95460991
142CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95381819
143PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95235590
144CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95050527
145P300_19829295_ChIP-Seq_ESCs_Human0.94865989
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94671462
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.94481983
148MYC_19829295_ChIP-Seq_ESCs_Human0.94476528
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93721041
150KDM5A_27292631_Chip-Seq_BREAST_Human0.93578367
151PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93407069
152MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92246309
153* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91534915
154TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91456554
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.90991573
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90411382
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90132600
158UTX_26944678_Chip-Seq_JUKART_Human0.90047240
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89719169
160* NANOG_20526341_ChIP-Seq_ESCs_Human0.89634188
161NFE2_27457419_Chip-Seq_LIVER_Mouse0.88407081
162ERG_20517297_ChIP-Seq_VCAP_Human0.88373505
163TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87558798
164TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87507443
165PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86927843
166HNFA_21074721_ChIP-Seq_CACO-2_Human0.86776217
167CBP_21632823_ChIP-Seq_H3396_Human0.86629074
168STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86176260
169STAT3_23295773_ChIP-Seq_U87_Human0.86105166
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.85938579
171CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85675456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.56077836
2MP0005360_urolithiasis4.13375132
3MP0003806_abnormal_nucleotide_metabolis3.93130597
4MP0005365_abnormal_bile_salt3.65812902
5MP0008004_abnormal_stomach_pH3.45161471
6MP0005085_abnormal_gallbladder_physiolo3.39328943
7MP0008875_abnormal_xenobiotic_pharmacok3.24727320
8MP0001835_abnormal_antigen_presentation2.61286592
9MP0009840_abnormal_foam_cell2.44772339
10MP0003656_abnormal_erythrocyte_physiolo2.42074463
11MP0003186_abnormal_redox_activity2.29270064
12MP0009785_altered_susceptibility_to2.16817976
13MP0003436_decreased_susceptibility_to2.16763870
14MP0001666_abnormal_nutrient_absorption2.05390963
15MP0010329_abnormal_lipoprotein_level1.96366242
16MP0000685_abnormal_immune_system1.94979339
17MP0003724_increased_susceptibility_to1.88535614
18MP0002138_abnormal_hepatobiliary_system1.87745352
19MP0002396_abnormal_hematopoietic_system1.86304833
20MP0005025_abnormal_response_to1.85810079
21MP0001764_abnormal_homeostasis1.85660565
22MP0002419_abnormal_innate_immunity1.80519200
23MP0002148_abnormal_hypersensitivity_rea1.80061136
24MP0002332_abnormal_exercise_endurance1.76908023
25MP0005083_abnormal_biliary_tract1.76126132
26MP0003191_abnormal_cellular_cholesterol1.74648134
27MP0005332_abnormal_amino_acid1.74252451
28MP0001800_abnormal_humoral_immune1.72118165
29MP0003252_abnormal_bile_duct1.69354367
30MP0005671_abnormal_response_to1.68913460
31MP0005464_abnormal_platelet_physiology1.67145904
32MP0000609_abnormal_liver_physiology1.64638183
33MP0005075_abnormal_melanosome_morpholog1.64528738
34MP0003195_calcinosis1.63749782
35MP0005410_abnormal_fertilization1.63510386
36MP0002166_altered_tumor_susceptibility1.61116339
37MP0005000_abnormal_immune_tolerance1.60715268
38MP0005387_immune_system_phenotype1.57395543
39MP0001790_abnormal_immune_system1.57395543
40MP0002132_abnormal_respiratory_system1.53732345
41MP0008469_abnormal_protein_level1.52001469
42MP0002723_abnormal_immune_serum1.51852258
43MP0003763_abnormal_thymus_physiology1.51801424
44MP0003646_muscle_fatigue1.51339932
45MP0003075_altered_response_to1.51123342
46MP0001501_abnormal_sleep_pattern1.50880635
47MP0005319_abnormal_enzyme/_coenzyme1.50532750
48MP0001545_abnormal_hematopoietic_system1.47032634
49MP0005397_hematopoietic_system_phenotyp1.47032634
50MP0002452_abnormal_antigen_presenting1.46747525
51MP0005058_abnormal_lysosome_morphology1.45703985
52MP0005584_abnormal_enzyme/coenzyme_acti1.44952044
53MP0002420_abnormal_adaptive_immunity1.43071753
54MP0006036_abnormal_mitochondrial_physio1.42332718
55MP0004147_increased_porphyrin_level1.41222792
56MP0009278_abnormal_bone_marrow1.40796748
57MP0001819_abnormal_immune_cell1.40662639
58MP0009643_abnormal_urine_homeostasis1.38501319
59MP0009333_abnormal_splenocyte_physiolog1.38222742
60MP0000490_abnormal_crypts_of1.37532057
61MP0001845_abnormal_inflammatory_respons1.36732141
62MP0003011_delayed_dark_adaptation1.36488251
63MP0005408_hypopigmentation1.35926382
64MP0004019_abnormal_vitamin_homeostasis1.33764418
65MP0005167_abnormal_blood-brain_barrier1.33743132
66MP0010155_abnormal_intestine_physiology1.32885752
67MP0004043_abnormal_pH_regulation1.31232486
68MP0002398_abnormal_bone_marrow1.31097622
69MP0000716_abnormal_immune_system1.27798664
70MP0002405_respiratory_system_inflammati1.27701816
71MP0002118_abnormal_lipid_homeostasis1.26501307
72MP0003172_abnormal_lysosome_physiology1.26487603
73MP0001853_heart_inflammation1.25328942
74MP0000689_abnormal_spleen_morphology1.25214811
75MP0003693_abnormal_embryo_hatching1.21776371
76MP0009763_increased_sensitivity_to1.19972354
77MP0009764_decreased_sensitivity_to1.17995008
78MP0002429_abnormal_blood_cell1.16975399
79MP0005670_abnormal_white_adipose1.16710265
80MP0002722_abnormal_immune_system1.15477156
81MP0004510_myositis1.14912998
82MP0006082_CNS_inflammation1.13376907
83MP0005636_abnormal_mineral_homeostasis1.13176867
84MP0003183_abnormal_peptide_metabolism1.10928367
85MP0005166_decreased_susceptibility_to1.10603332
86MP0002736_abnormal_nociception_after1.10327749
87MP0000598_abnormal_liver_morphology1.06291361
88MP0005535_abnormal_body_temperature1.06058223
89MP0002006_tumorigenesis1.04053101
90MP0003868_abnormal_feces_composition1.03713429
91MP0003718_maternal_effect1.02936155
92MP0000569_abnormal_digit_pigmentation1.02194732
93MP0005451_abnormal_body_composition1.01479537
94MP0008877_abnormal_DNA_methylation0.98296231
95MP0005164_abnormal_response_to0.93917326
96MP0002876_abnormal_thyroid_physiology0.93915706
97MP0003303_peritoneal_inflammation0.93600017
98MP0004947_skin_inflammation0.92892358
99MP0008057_abnormal_DNA_replication0.92500058
100MP0000604_amyloidosis0.92266360
101MP0002277_abnormal_respiratory_mucosa0.91915723
102MP0001873_stomach_inflammation0.91367705
103MP0005377_hearing/vestibular/ear_phenot0.91243896
104MP0003878_abnormal_ear_physiology0.91243896
105MP0003866_abnormal_defecation0.88594810
106MP0005551_abnormal_eye_electrophysiolog0.87789508
107MP0000465_gastrointestinal_hemorrhage0.86718655
108MP0005376_homeostasis/metabolism_phenot0.85414334
109MP0006054_spinal_hemorrhage0.84537420
110MP0009697_abnormal_copulation0.84019807
111MP0000343_altered_response_to0.84017980
112MP0002653_abnormal_ependyma_morphology0.82926479
113MP0006035_abnormal_mitochondrial_morpho0.82239763
114MP0005174_abnormal_tail_pigmentation0.81997842
115MP0004264_abnormal_extraembryonic_tissu0.81863873
116MP0010094_abnormal_chromosome_stability0.81397770
117MP0001533_abnormal_skeleton_physiology0.81276730
118MP0002019_abnormal_tumor_incidence0.80132677
119MP0005310_abnormal_salivary_gland0.79988866
120MP0009642_abnormal_blood_homeostasis0.79707608
121MP0000858_altered_metastatic_potential0.79458821
122MP0009765_abnormal_xenobiotic_induced0.78271499
123MP0002254_reproductive_system_inflammat0.78207241
124MP0005220_abnormal_exocrine_pancreas0.75388785
125MP0005647_abnormal_sex_gland0.75270913
126MP0004381_abnormal_hair_follicle0.73621466
127MP0005266_abnormal_metabolism0.73440881
128MP0001663_abnormal_digestive_system0.73370385
129MP0008873_increased_physiological_sensi0.73367385
130MP0005395_other_phenotype0.72961224
131MP0003879_abnormal_hair_cell0.67806570
132MP0000230_abnormal_systemic_arterial0.67304567

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41980855
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.26891179
3Abnormal respiratory motile cilium physiology (HP:0012261)3.97980197
4Abnormal ciliary motility (HP:0012262)3.95044276
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.91405997
6Absent/shortened dynein arms (HP:0200106)3.88958473
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.88958473
8Abnormal respiratory motile cilium morphology (HP:0005938)3.84038623
9Abnormal respiratory epithelium morphology (HP:0012253)3.84038623
10Prolonged partial thromboplastin time (HP:0003645)3.63529183
11Intrahepatic cholestasis (HP:0001406)3.60370619
12Hypobetalipoproteinemia (HP:0003563)3.49270303
13Rhinitis (HP:0012384)3.38493937
14Deep venous thrombosis (HP:0002625)3.18834346
15Joint hemorrhage (HP:0005261)3.18417333
16Recurrent bacterial skin infections (HP:0005406)3.16736756
17Abnormality of fatty-acid metabolism (HP:0004359)3.14464755
18Xanthomatosis (HP:0000991)3.09428493
19Stomatitis (HP:0010280)3.08772211
20Recurrent gram-negative bacterial infections (HP:0005420)3.06768060
21Abnormality of pyrimidine metabolism (HP:0004353)3.00412944
22Retrobulbar optic neuritis (HP:0100654)3.00005051
23Optic neuritis (HP:0100653)3.00005051
24IgM deficiency (HP:0002850)2.99894227
25Elevated erythrocyte sedimentation rate (HP:0003565)2.99211704
26Generalized aminoaciduria (HP:0002909)2.98485397
27Thrombocytosis (HP:0001894)2.97258809
28Recurrent abscess formation (HP:0002722)2.95805818
29Hyperammonemia (HP:0001987)2.94991014
30Hypoglycemic coma (HP:0001325)2.93350059
31Hyperbilirubinemia (HP:0002904)2.93147572
32Hyperlipoproteinemia (HP:0010980)2.92237012
33Complement deficiency (HP:0004431)2.92173166
34Orchitis (HP:0100796)2.86730547
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82109372
36Dicarboxylic aciduria (HP:0003215)2.82109372
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77025614
38Abnormal number of erythroid precursors (HP:0012131)2.75563449
39Abnormality of the common coagulation pathway (HP:0010990)2.75524780
40Systemic lupus erythematosus (HP:0002725)2.75466777
41Amyloidosis (HP:0011034)2.73836429
42Abnormality of cells of the erythroid lineage (HP:0012130)2.66014714
43Pancreatic cysts (HP:0001737)2.63554747
44Ketosis (HP:0001946)2.61211589
45Vacuolated lymphocytes (HP:0001922)2.58542965
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.57570485
47Reduced antithrombin III activity (HP:0001976)2.57212446
48Chronic otitis media (HP:0000389)2.54630363
49Fat malabsorption (HP:0002630)2.54439179
50Hepatic necrosis (HP:0002605)2.54437955
51Eczematoid dermatitis (HP:0000976)2.52985919
52Bronchiectasis (HP:0002110)2.49671923
53Abnormality of methionine metabolism (HP:0010901)2.49580027
54Petechiae (HP:0000967)2.45107709
55Abnormality of complement system (HP:0005339)2.45044085
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42635645
57True hermaphroditism (HP:0010459)2.41973582
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.41053213
59Severe visual impairment (HP:0001141)2.40664677
60Hypoplasia of the thymus (HP:0000778)2.37469763
61Pancreatic fibrosis (HP:0100732)2.37326231
62Aplastic anemia (HP:0001915)2.35418831
63Abnormality of serine family amino acid metabolism (HP:0010894)2.32215019
64Abnormality of glycine metabolism (HP:0010895)2.32215019
65Reticulocytopenia (HP:0001896)2.32183528
66Hyperglycinuria (HP:0003108)2.31315277
67Hyperglycinemia (HP:0002154)2.28998558
68Molar tooth sign on MRI (HP:0002419)2.27104764
69Abnormality of midbrain morphology (HP:0002418)2.27104764
70Steatorrhea (HP:0002570)2.25177476
713-Methylglutaconic aciduria (HP:0003535)2.24736601
72Recurrent skin infections (HP:0001581)2.24309260
73Methylmalonic aciduria (HP:0012120)2.22732539
74Hypolipoproteinemia (HP:0010981)2.22671815
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21877097
76Abnormality of liposaccharide metabolism (HP:0010968)2.20154109
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.20154109
78Abnormality of glycolipid metabolism (HP:0010969)2.20154109
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19046633
80Chronic hepatic failure (HP:0100626)2.18916631
81Neutropenia (HP:0001875)2.18017332
82Abnormality of nucleobase metabolism (HP:0010932)2.17998772
83Tubulointerstitial nephritis (HP:0001970)2.17986495
84Gangrene (HP:0100758)2.16146149
85Abnormality of the renal cortex (HP:0011035)2.15961508
86Abnormality of T cell physiology (HP:0011840)2.15934041
87Abnormality of iron homeostasis (HP:0011031)2.15642172
88Medial flaring of the eyebrow (HP:0010747)2.15285256
89Abnormality of transition element cation homeostasis (HP:0011030)2.14178243
90Cerebral edema (HP:0002181)2.13699687
91Hepatocellular necrosis (HP:0001404)2.12822733
92Lethargy (HP:0001254)2.12296569
93Autoimmune thrombocytopenia (HP:0001973)2.12277117
94Nausea (HP:0002018)2.10446340
95Nasal polyposis (HP:0100582)2.09537107
96Epistaxis (HP:0000421)2.09051885
97Glycosuria (HP:0003076)2.08124285
98Abnormality of urine glucose concentration (HP:0011016)2.08124285
99Recurrent viral infections (HP:0004429)2.07183066
100Gingival bleeding (HP:0000225)2.06343289
101Nephronophthisis (HP:0000090)2.06005026
102Abnormality of macrophages (HP:0004311)2.05894995
103Congenital sensorineural hearing impairment (HP:0008527)2.05826568
104Increased serum ferritin (HP:0003281)2.05606992
105Chronic bronchitis (HP:0004469)2.04451910
106Metabolic acidosis (HP:0001942)2.02913446
107Myositis (HP:0100614)2.02622320
108Encephalitis (HP:0002383)2.02612395
109Renal cortical cysts (HP:0000803)2.02574429
110Acute encephalopathy (HP:0006846)2.01725302
111Recurrent bronchitis (HP:0002837)2.00939627
112Abnormality of the prostate (HP:0008775)2.00193456
113Glomerulonephritis (HP:0000099)1.99410378
114Acanthocytosis (HP:0001927)1.98783795
115Panhypogammaglobulinemia (HP:0003139)1.97993140
116Ketoacidosis (HP:0001993)1.97816034
117Spontaneous hematomas (HP:0007420)1.97539476
118Pustule (HP:0200039)1.97475210
119Increased cerebral lipofuscin (HP:0011813)1.96799656
120Abnormality of the intrinsic pathway (HP:0010989)1.96699855
121Poikilocytosis (HP:0004447)1.96181043
122Conjugated hyperbilirubinemia (HP:0002908)1.95336038
123Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94911240
124Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94911240
125Congenital stationary night blindness (HP:0007642)1.94548979
126Joint swelling (HP:0001386)1.93425949
127Granulocytopenia (HP:0001913)1.93307512
128Meningitis (HP:0001287)1.93138164
129Vomiting (HP:0002013)1.92873542
130Azoospermia (HP:0000027)1.92834792
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.92560700
132Recurrent sinusitis (HP:0011108)1.92228187
133Pancreatitis (HP:0001733)1.92060603
134Abnormality of serum amino acid levels (HP:0003112)1.91737715
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91189593
136Delayed CNS myelination (HP:0002188)1.90997614
137Pancytopenia (HP:0001876)1.90389368
138Periodontitis (HP:0000704)1.90178784
139Abnormality of the renal medulla (HP:0100957)1.89289540
140Type I transferrin isoform profile (HP:0003642)1.88958815
141Parakeratosis (HP:0001036)1.88246753
142Keratoconjunctivitis sicca (HP:0001097)1.88164648
143Eosinophilia (HP:0001880)1.88025954
144Abnormal rod and cone electroretinograms (HP:0008323)1.87025570
145Increased CSF lactate (HP:0002490)1.85151628
146Mitochondrial inheritance (HP:0001427)1.84820431
147Autoimmune hemolytic anemia (HP:0001890)1.84542877
148Spontaneous abortion (HP:0005268)1.82891748
149Acute necrotizing encephalopathy (HP:0006965)1.80401422
150Pigmentary retinal degeneration (HP:0001146)1.78708456
151Decreased central vision (HP:0007663)1.78455196
152Abnormal mitochondria in muscle tissue (HP:0008316)1.76958877
153Episodic fever (HP:0001954)1.75930825
154Anorexia (HP:0002039)1.75635109
155Keratoconjunctivitis (HP:0001096)1.74382083
156Congenital hepatic fibrosis (HP:0002612)1.74350906
157Abolished electroretinogram (ERG) (HP:0000550)1.73436991
158Stomach cancer (HP:0012126)1.71679006
159Methylmalonic acidemia (HP:0002912)1.70246632
160Hypoalphalipoproteinemia (HP:0003233)1.70104459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.43682643
2MAP4K13.01845501
3PDK22.88843830
4TAOK32.81354990
5STK162.79088942
6PIM22.73023041
7BCKDK2.71120168
8BLK2.70953340
9KIT2.56803190
10TEC2.55917738
11NME22.54896999
12IRAK42.52442941
13ERN12.41267914
14BTK2.34309675
15TBK12.19473807
16FLT32.12320137
17GRK72.10939397
18TYK22.10357702
19PINK12.04605122
20MAP4K21.98359783
21IRAK31.88604534
22ZAP701.87680088
23IRAK21.84676765
24MAP3K141.72284721
25ADRBK21.68285233
26IKBKE1.66052919
27TNK21.61532952
28EPHB11.54485002
29MAP3K31.53382946
30BMPR21.49200387
31CSF1R1.48770671
32JAK31.45084428
33MAP3K61.43983170
34EIF2AK11.43832182
35SYK1.42651716
36FGFR41.39094316
37STK38L1.38591515
38MAP2K31.37582675
39CLK11.37031671
40EIF2AK31.33617526
41VRK11.33313479
42GRK11.33200324
43TXK1.31067220
44ARAF1.30262590
45BUB11.24586480
46ITK1.23531008
47WNK31.23199010
48STK101.21635406
49IKBKB1.19496955
50KDR1.19087770
51TNIK1.17185940
52MUSK1.16991708
53OXSR11.16393190
54ABL21.14699940
55BMPR1B1.14352721
56PTK2B1.13418499
57PASK1.08447863
58ACVR1B1.08017234
59MAP3K111.07947695
60LYN1.05834205
61NLK0.99174015
62PIM10.98090337
63GRK60.96645189
64LRRK20.95657967
65NME10.94693598
66INSRR0.92056320
67TESK20.91290088
68TAOK20.90655481
69JAK10.90500988
70BRAF0.88510771
71OBSCN0.88354121
72MAPK150.84845987
73MAP3K120.84298286
74ZAK0.83670394
75LCK0.82319144
76FES0.81549380
77STK40.81332744
78MAPK40.80772799
79AKT30.80065643
80JAK20.80030722
81MAP3K40.79569197
82SIK10.79134099
83EPHA30.78819251
84PBK0.78778844
85CDK40.78202060
86MST40.75685227
87MAPK130.75191436
88NTRK30.75149945
89MAPK110.74224782
90WEE10.72840822
91RIPK40.72775042
92PRKAA20.71644833
93TLK10.70364698
94MAP3K130.69403466
95DYRK30.63866124
96PIK3CG0.63808946
97MAP3K50.63604514
98MAP3K80.61559043
99STK380.60652416
100CSK0.59468126
101TESK10.57772010
102CAMKK20.57337860
103STK240.56489613
104CDK70.56336717
105RPS6KA60.55991743
106IRAK10.55963491
107TGFBR10.55595893
108CCNB10.55155635
109ATR0.54207843
110NUAK10.53952789
111HCK0.52297974
112FER0.52117272
113MAP2K70.51486244
114PRKCD0.51465699
115MAPKAPK30.50415991
116MAP2K60.50394350
117EPHA20.49278307
118RAF10.48895498
119DAPK20.48738130
120RPS6KL10.48015272
121RPS6KC10.48015272
122PRKCQ0.46326583
123TRIM280.46276865
124SCYL20.44966758
125MATK0.44787654
126RPS6KA40.44680832
127PDK10.44115471
128CHUK0.43073385
129HIPK20.43014800
130MAP3K10.41972323
131CASK0.41229468
132IGF1R0.39876338
133MOS0.39690057
134TGFBR20.39426837
135PRKACG0.38873474
136LMTK20.38871033
137CDK60.38416072
138CDK190.38410085
139BRSK20.38266935
140MAPK70.37670524
141CDC70.37384317
142MST1R0.36495634
143CSNK2A10.35609098
144MARK30.35517631
145PRKG20.35506454
146ADRBK10.34537991
147AURKB0.33875896
148PKN10.33835898
149TTK0.32839841
150CSNK1A1L0.32732119
151EIF2AK20.31801477
152BCR0.31682341
153SGK30.30776025
154MAPKAPK20.30622392

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.11697188
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41149748
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16984076
4Drug metabolism - other enzymes_Homo sapiens_hsa009832.07898082
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02581394
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02367663
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.98234408
8Peroxisome_Homo sapiens_hsa041461.92214663
9Folate biosynthesis_Homo sapiens_hsa007901.88506217
10Fatty acid degradation_Homo sapiens_hsa000711.87131141
11Tryptophan metabolism_Homo sapiens_hsa003801.84239344
12Protein export_Homo sapiens_hsa030601.83609490
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82468347
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81884905
15Staphylococcus aureus infection_Homo sapiens_hsa051501.81609673
16Complement and coagulation cascades_Homo sapiens_hsa046101.80919240
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80311419
18Selenocompound metabolism_Homo sapiens_hsa004501.75238490
19DNA replication_Homo sapiens_hsa030301.75148412
20Linoleic acid metabolism_Homo sapiens_hsa005911.75087122
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74039200
22Ribosome_Homo sapiens_hsa030101.73535603
23Rheumatoid arthritis_Homo sapiens_hsa053231.72908256
24Histidine metabolism_Homo sapiens_hsa003401.70936920
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69281666
26Chemical carcinogenesis_Homo sapiens_hsa052041.69033630
27One carbon pool by folate_Homo sapiens_hsa006701.65907898
28Arginine biosynthesis_Homo sapiens_hsa002201.58428766
29Sulfur relay system_Homo sapiens_hsa041221.58291379
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54889048
31Propanoate metabolism_Homo sapiens_hsa006401.49647811
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48602063
33Proteasome_Homo sapiens_hsa030501.46827746
34Caffeine metabolism_Homo sapiens_hsa002321.43924010
35Arachidonic acid metabolism_Homo sapiens_hsa005901.42048948
36Sulfur metabolism_Homo sapiens_hsa009201.38736843
37Graft-versus-host disease_Homo sapiens_hsa053321.37600481
38Glutathione metabolism_Homo sapiens_hsa004801.37333238
39beta-Alanine metabolism_Homo sapiens_hsa004101.33079983
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.30008405
41Fatty acid elongation_Homo sapiens_hsa000621.28045949
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.26474100
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.25585047
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22579453
45* Pentose phosphate pathway_Homo sapiens_hsa000301.22060151
46Retinol metabolism_Homo sapiens_hsa008301.21724805
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20725330
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17874909
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16621530
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12472653
51Nitrogen metabolism_Homo sapiens_hsa009101.10869109
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10628853
53Pyrimidine metabolism_Homo sapiens_hsa002401.10486682
54TNF signaling pathway_Homo sapiens_hsa046681.10399762
55Homologous recombination_Homo sapiens_hsa034401.09734972
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09266372
57Starch and sucrose metabolism_Homo sapiens_hsa005001.08634927
58Primary immunodeficiency_Homo sapiens_hsa053401.07656034
59African trypanosomiasis_Homo sapiens_hsa051431.04719528
60Phenylalanine metabolism_Homo sapiens_hsa003601.04664694
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04128720
62Fatty acid metabolism_Homo sapiens_hsa012121.03605617
63Asthma_Homo sapiens_hsa053101.02777467
64ABC transporters_Homo sapiens_hsa020101.01648037
65Vitamin digestion and absorption_Homo sapiens_hsa049771.00130855
66Carbon metabolism_Homo sapiens_hsa012000.99531244
67Biosynthesis of amino acids_Homo sapiens_hsa012300.99123980
68Type I diabetes mellitus_Homo sapiens_hsa049400.99104694
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.98437332
70Mineral absorption_Homo sapiens_hsa049780.98204745
71Butanoate metabolism_Homo sapiens_hsa006500.97252955
72PPAR signaling pathway_Homo sapiens_hsa033200.96741524
73Sphingolipid metabolism_Homo sapiens_hsa006000.96150139
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95859238
75Mismatch repair_Homo sapiens_hsa034300.95005241
76Fat digestion and absorption_Homo sapiens_hsa049750.92583132
77Base excision repair_Homo sapiens_hsa034100.92324796
78Collecting duct acid secretion_Homo sapiens_hsa049660.91002102
79Tyrosine metabolism_Homo sapiens_hsa003500.90926807
80Pyruvate metabolism_Homo sapiens_hsa006200.90784295
81Arginine and proline metabolism_Homo sapiens_hsa003300.83077239
82Regulation of autophagy_Homo sapiens_hsa041400.82346090
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80337856
84Steroid biosynthesis_Homo sapiens_hsa001000.79635649
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77971435
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.75825420
87Salmonella infection_Homo sapiens_hsa051320.74504092
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72667588
89Non-homologous end-joining_Homo sapiens_hsa034500.71571481
90Galactose metabolism_Homo sapiens_hsa000520.71341476
91Leishmaniasis_Homo sapiens_hsa051400.69400526
92Autoimmune thyroid disease_Homo sapiens_hsa053200.69171544
93Glycerolipid metabolism_Homo sapiens_hsa005610.69097994
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69090232
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68580731
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68333584
97Legionellosis_Homo sapiens_hsa051340.67767333
98Tuberculosis_Homo sapiens_hsa051520.66628040
99Malaria_Homo sapiens_hsa051440.66030019
100Osteoclast differentiation_Homo sapiens_hsa043800.65969020
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65124285
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64488595
103* Metabolic pathways_Homo sapiens_hsa011000.62865635
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62619272
105Vitamin B6 metabolism_Homo sapiens_hsa007500.61669887
106Influenza A_Homo sapiens_hsa051640.59353475
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59233605
108Bile secretion_Homo sapiens_hsa049760.58652687
109Nucleotide excision repair_Homo sapiens_hsa034200.57895311
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56423519
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.54461004
112Other glycan degradation_Homo sapiens_hsa005110.54236982
113Measles_Homo sapiens_hsa051620.52964381
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.52813159
115Antigen processing and presentation_Homo sapiens_hsa046120.52424885
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51573740
117Pertussis_Homo sapiens_hsa051330.50530442
118Hematopoietic cell lineage_Homo sapiens_hsa046400.49314252
119RNA polymerase_Homo sapiens_hsa030200.47637953
120Herpes simplex infection_Homo sapiens_hsa051680.46662285
121Huntingtons disease_Homo sapiens_hsa050160.46455660
122Parkinsons disease_Homo sapiens_hsa050120.46125369
123Ether lipid metabolism_Homo sapiens_hsa005650.45610206
124Fatty acid biosynthesis_Homo sapiens_hsa000610.45148571
125Oxidative phosphorylation_Homo sapiens_hsa001900.44318046
126Allograft rejection_Homo sapiens_hsa053300.42509948
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41644607
128Fructose and mannose metabolism_Homo sapiens_hsa000510.38570789
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35382104
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35237785
131N-Glycan biosynthesis_Homo sapiens_hsa005100.35153188
132Systemic lupus erythematosus_Homo sapiens_hsa053220.35080922
133B cell receptor signaling pathway_Homo sapiens_hsa046620.34732196
134Lysosome_Homo sapiens_hsa041420.34349624

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