RBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)4.57645794
2DNA unwinding involved in DNA replication (GO:0006268)4.44068935
3protein localization to kinetochore (GO:0034501)4.42040780
4replication fork processing (GO:0031297)4.02046170
5protein K6-linked ubiquitination (GO:0085020)3.96144759
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90722827
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90722827
8regulation of centrosome cycle (GO:0046605)3.89937212
9DNA strand elongation involved in DNA replication (GO:0006271)3.87481045
10protein localization to chromosome, centromeric region (GO:0071459)3.86081024
11double-strand break repair via nonhomologous end joining (GO:0006303)3.84347570
12non-recombinational repair (GO:0000726)3.84347570
13regulation of sister chromatid cohesion (GO:0007063)3.83501288
14positive regulation of gamma-delta T cell activation (GO:0046645)3.81360423
15telomere maintenance via semi-conservative replication (GO:0032201)3.76363169
16DNA strand elongation (GO:0022616)3.69951363
17mitotic chromosome condensation (GO:0007076)3.64967659
18regulation of centrosome duplication (GO:0010824)3.62473441
19ribosomal small subunit assembly (GO:0000028)3.61958360
20mitotic recombination (GO:0006312)3.61907158
21kinetochore organization (GO:0051383)3.61816592
22sister chromatid cohesion (GO:0007062)3.61139413
23antigen processing and presentation of endogenous antigen (GO:0019883)3.60982343
24spindle checkpoint (GO:0031577)3.57751328
25telomere maintenance via recombination (GO:0000722)3.55783697
26nuclear pore complex assembly (GO:0051292)3.54943798
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.54669286
28regulation of chromosome segregation (GO:0051983)3.51266386
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.49942246
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49942246
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49942246
32histone-serine phosphorylation (GO:0035404)3.49468952
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48429961
34recombinational repair (GO:0000725)3.47427221
35double-strand break repair via homologous recombination (GO:0000724)3.44636925
36sister chromatid segregation (GO:0000819)3.43411410
37DNA ligation (GO:0006266)3.43399620
38mitotic spindle checkpoint (GO:0071174)3.43173516
39DNA replication initiation (GO:0006270)3.42647007
40regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40015035
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40015035
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.38361629
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38361629
44mitotic sister chromatid cohesion (GO:0007064)3.38299102
45synapsis (GO:0007129)3.35969056
46negative regulation of chromosome segregation (GO:0051985)3.35301337
47nuclear pore organization (GO:0006999)3.34658571
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34080505
49negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.32655218
50regulation of sister chromatid segregation (GO:0033045)3.31186373
51regulation of mitotic sister chromatid separation (GO:0010965)3.31186373
52regulation of mitotic sister chromatid segregation (GO:0033047)3.31186373
53microtubule depolymerization (GO:0007019)3.30828672
54V(D)J recombination (GO:0033151)3.27701104
55mitotic sister chromatid segregation (GO:0000070)3.26322104
56mitotic G2/M transition checkpoint (GO:0044818)3.26125468
57* mitotic cell cycle (GO:0000278)3.25762370
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.25348414
59negative regulation of sister chromatid segregation (GO:0033046)3.25348414
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25348414
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25348414
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25348414
63DNA strand renaturation (GO:0000733)3.25314456
64DNA double-strand break processing (GO:0000729)3.22922825
65mitotic spindle assembly checkpoint (GO:0007094)3.22820999
66centriole replication (GO:0007099)3.22153017
67spindle assembly checkpoint (GO:0071173)3.21929897
68negative regulation of cell cycle G2/M phase transition (GO:1902750)3.18132944
69meiotic chromosome segregation (GO:0045132)3.17926612
70CENP-A containing nucleosome assembly (GO:0034080)3.10066419
71translesion synthesis (GO:0019985)3.09922168
72DNA topological change (GO:0006265)3.05820196
73chromatin remodeling at centromere (GO:0031055)3.01086923
74mitotic nuclear envelope disassembly (GO:0007077)2.99057732
75nucleotide-excision repair, DNA gap filling (GO:0006297)2.98731254
76regulation of DNA endoreduplication (GO:0032875)2.97228523
77DNA replication checkpoint (GO:0000076)2.96389492
78DNA duplex unwinding (GO:0032508)2.91441571
79DNA geometric change (GO:0032392)2.91289219
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90832518
81DNA replication-independent nucleosome organization (GO:0034724)2.87689652
82DNA replication-independent nucleosome assembly (GO:0006336)2.87689652
83attachment of spindle microtubules to kinetochore (GO:0008608)2.86924931
84telomere maintenance via telomere lengthening (GO:0010833)2.84493950
85kinetochore assembly (GO:0051382)2.80231032
86regulation of histone H3-K9 methylation (GO:0051570)2.78923381
87dosage compensation (GO:0007549)2.77577835
88membrane disassembly (GO:0030397)2.75547655
89nuclear envelope disassembly (GO:0051081)2.75547655
90pore complex assembly (GO:0046931)2.73443924
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73051075
92positive regulation of B cell differentiation (GO:0045579)2.68097535
93protein localization to chromosome (GO:0034502)2.64422252
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64265785
95chromatin assembly or disassembly (GO:0006333)2.63750800
96telomere maintenance (GO:0000723)2.61627134
97regulation of gamma-delta T cell differentiation (GO:0045586)2.61061945
98mitotic metaphase plate congression (GO:0007080)2.59541134
99viral transcription (GO:0019083)2.58239378
100telomere organization (GO:0032200)2.57586485
101DNA conformation change (GO:0071103)2.56666263
102regulation of gamma-delta T cell activation (GO:0046643)2.55608322
103chromosome condensation (GO:0030261)2.54245947
104definitive hemopoiesis (GO:0060216)2.53307859
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52528158
106establishment of chromosome localization (GO:0051303)2.51947201
107hepatocyte apoptotic process (GO:0097284)2.51366548
108translational termination (GO:0006415)2.49879488
109chromosome segregation (GO:0007059)2.48790172
110folic acid-containing compound biosynthetic process (GO:0009396)2.47888171
111DNA synthesis involved in DNA repair (GO:0000731)2.47487741
112NIK/NF-kappaB signaling (GO:0038061)2.46396661
113leukocyte aggregation (GO:0070486)2.45581510
114immunoglobulin mediated immune response (GO:0016064)2.45555376
115natural killer cell mediated cytotoxicity (GO:0042267)2.45411095
116natural killer cell mediated immunity (GO:0002228)2.45411095
117regulation of interleukin-12 biosynthetic process (GO:0045075)2.45233416
118histone exchange (GO:0043486)2.44824904
119IMP biosynthetic process (GO:0006188)2.43901842
120negative regulation of phagocytosis (GO:0050765)2.43333928
121DNA replication-dependent nucleosome assembly (GO:0006335)2.43149975
122DNA replication-dependent nucleosome organization (GO:0034723)2.43149975
123regulation of spindle organization (GO:0090224)2.42803502
124alternative mRNA splicing, via spliceosome (GO:0000380)2.42747600
125metaphase plate congression (GO:0051310)2.40399004
126negative regulation of RNA splicing (GO:0033119)2.40261627
127postreplication repair (GO:0006301)2.39268909
128regulation of alpha-beta T cell proliferation (GO:0046640)2.38733833
129B cell mediated immunity (GO:0019724)2.36817489
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.36781403
131ATP-dependent chromatin remodeling (GO:0043044)2.36336107
132negative regulation of histone methylation (GO:0031061)2.35127145
133negative T cell selection (GO:0043383)2.35058223
134regulation of B cell differentiation (GO:0045577)2.32907780
135positive regulation of interferon-alpha production (GO:0032727)2.32828627
136regulation of B cell receptor signaling pathway (GO:0050855)2.32381281
137regulation of protein heterodimerization activity (GO:0043497)2.31199989
138response to type I interferon (GO:0034340)2.30502380
139negative thymic T cell selection (GO:0045060)2.30472120
140histone mRNA catabolic process (GO:0071044)2.30362245
141positive regulation of chromosome segregation (GO:0051984)2.30311289
142T cell homeostasis (GO:0043029)2.29812809
143IMP metabolic process (GO:0046040)2.29146162
144chromatin assembly (GO:0031497)2.29001039
145DNA packaging (GO:0006323)2.28807552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.93546184
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86824279
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.58156416
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.24172175
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.22630594
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09780837
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62547436
8* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59028385
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55212365
10MYC_22102868_ChIP-Seq_BL_Human2.44984484
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.42037311
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.34925615
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29352080
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25543344
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24113811
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16428683
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.13586564
18VDR_21846776_ChIP-Seq_THP-1_Human2.04018782
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03676423
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02307788
21* E2F7_22180533_ChIP-Seq_HELA_Human10.0098861
22AR_21909140_ChIP-Seq_LNCAP_Human1.98078874
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94967539
24SCL_19346495_ChIP-Seq_HPC-7_Human1.94419431
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90105998
26MYB_26560356_Chip-Seq_TH2_Human1.80989237
27* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76596969
28* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74765424
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74403004
30SPI1_23547873_ChIP-Seq_NB4_Human1.73468437
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64651285
32MYB_26560356_Chip-Seq_TH1_Human1.64131686
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62645269
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60115074
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60066568
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.59723486
37MAF_26560356_Chip-Seq_TH1_Human1.58884278
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56356514
39* VDR_23849224_ChIP-Seq_CD4+_Human1.55878750
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51090441
41* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50963491
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49558635
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48382555
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47682411
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46394272
46CIITA_25753668_ChIP-Seq_RAJI_Human1.46270501
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45130913
48ELK1_19687146_ChIP-ChIP_HELA_Human1.45091072
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44791366
50* EST1_17652178_ChIP-ChIP_JURKAT_Human1.44567948
51VDR_24763502_ChIP-Seq_THP-1_Human1.44206258
52UTX_26944678_Chip-Seq_JUKART_Human1.44148170
53FOXP3_21729870_ChIP-Seq_TREG_Human1.43207259
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43189410
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41891407
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41518218
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38914497
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38327129
59* RUNX1_22412390_ChIP-Seq_EML_Mouse1.38164394
60XRN2_22483619_ChIP-Seq_HELA_Human1.37987245
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37750866
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36680155
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35666523
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34402550
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.33204082
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32170960
67MYC_18940864_ChIP-ChIP_HL60_Human1.30549603
68EWS_26573619_Chip-Seq_HEK293_Human1.29097166
69FUS_26573619_Chip-Seq_HEK293_Human1.28817104
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26374173
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25811527
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25763130
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25007569
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.24306764
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24004939
76TCF7_22412390_ChIP-Seq_EML_Mouse1.23528357
77IRF1_19129219_ChIP-ChIP_H3396_Human1.23195992
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22455824
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21735770
80IGF1R_20145208_ChIP-Seq_DFB_Human1.20748267
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18935648
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18168148
83DCP1A_22483619_ChIP-Seq_HELA_Human1.16084529
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14702871
85ZNF274_21170338_ChIP-Seq_K562_Hela1.14063613
86* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13806661
87TFEB_21752829_ChIP-Seq_HELA_Human1.11993319
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11693674
89KDM5A_27292631_Chip-Seq_BREAST_Human1.11120100
90GATA1_22025678_ChIP-Seq_K562_Human1.11116229
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.11093371
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08719859
93RUNX_20019798_ChIP-Seq_JUKART_Human1.07810377
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.06012120
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04807472
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.02593365
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02297028
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02262450
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01490758
100* ETS1_20019798_ChIP-Seq_JURKAT_Human1.01373221
101TTF2_22483619_ChIP-Seq_HELA_Human0.99772946
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.98456027
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97753933
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96904565
105MAF_26560356_Chip-Seq_TH2_Human0.96313489
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95666458
107PU_27001747_Chip-Seq_BMDM_Mouse0.94464489
108GABP_19822575_ChIP-Seq_HepG2_Human0.94419414
109E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93871770
110VDR_22108803_ChIP-Seq_LS180_Human0.92900208
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92829914
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92028307
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91180517
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90421911
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90136575
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89751786
117GATA3_27048872_Chip-Seq_THYMUS_Human0.89595502
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87488106
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86410471
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85952123
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85937052
122* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85322558
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84998366
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80172721
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77682469
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.74358858
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72731844
128ER_23166858_ChIP-Seq_MCF-7_Human0.72529770
129* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.69979510
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.67078271
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.66907798
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.66657929
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66638881
134RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63950201
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.62904356
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.62294064
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.61770787
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.61128781
139* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.60583365
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.60106697
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.59503831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.28251714
2MP0008057_abnormal_DNA_replication3.12551616
3MP0002396_abnormal_hematopoietic_system3.07525029
4MP0003693_abnormal_embryo_hatching3.06613189
5MP0001835_abnormal_antigen_presentation3.01256397
6MP0009697_abnormal_copulation2.90265113
7MP0003111_abnormal_nucleus_morphology2.75561765
8MP0003077_abnormal_cell_cycle2.54739209
9MP0003763_abnormal_thymus_physiology2.39249400
10MP0000685_abnormal_immune_system2.37549663
11MP0004808_abnormal_hematopoietic_stem2.28835018
12MP0000372_irregular_coat_pigmentation2.28529925
13MP0001800_abnormal_humoral_immune2.25049730
14MP0005671_abnormal_response_to2.16802432
15MP0003436_decreased_susceptibility_to2.15621389
16* MP0002398_abnormal_bone_marrow2.14498651
17MP0004957_abnormal_blastocyst_morpholog2.11219662
18MP0009785_altered_susceptibility_to2.10280657
19MP0010352_gastrointestinal_tract_polyps2.09398447
20MP0005397_hematopoietic_system_phenotyp2.07727011
21MP0001545_abnormal_hematopoietic_system2.07727011
22MP0002452_abnormal_antigen_presenting2.04241779
23MP0002166_altered_tumor_susceptibility2.03618087
24MP0003950_abnormal_plasma_membrane1.98425417
25MP0008058_abnormal_DNA_repair1.98211410
26MP0010307_abnormal_tumor_latency1.97405310
27MP0000490_abnormal_crypts_of1.95060979
28MP0008007_abnormal_cellular_replicative1.94731916
29MP0001819_abnormal_immune_cell1.92095428
30MP0002420_abnormal_adaptive_immunity1.92072865
31MP0005000_abnormal_immune_tolerance1.89214820
32MP0009278_abnormal_bone_marrow1.88684709
33MP0005387_immune_system_phenotype1.88440364
34MP0001790_abnormal_immune_system1.88440364
35MP0002723_abnormal_immune_serum1.87462859
36MP0005025_abnormal_response_to1.78717347
37MP0002006_tumorigenesis1.77879121
38MP0002722_abnormal_immune_system1.77808013
39* MP0000689_abnormal_spleen_morphology1.75240605
40MP0000703_abnormal_thymus_morphology1.74467616
41MP0000716_abnormal_immune_system1.74408772
42MP0009333_abnormal_splenocyte_physiolog1.72961802
43MP0002148_abnormal_hypersensitivity_rea1.69942326
44MP0006054_spinal_hemorrhage1.63557546
45MP0003300_gastrointestinal_ulcer1.61805070
46MP0002419_abnormal_innate_immunity1.61669907
47MP0003303_peritoneal_inflammation1.61418619
48* MP0002429_abnormal_blood_cell1.60214175
49MP0002405_respiratory_system_inflammati1.58307827
50MP0005408_hypopigmentation1.55691845
51MP0001873_stomach_inflammation1.55560409
52MP0010155_abnormal_intestine_physiology1.54356907
53MP0005076_abnormal_cell_differentiation1.51168963
54MP0005464_abnormal_platelet_physiology1.51127003
55MP0002019_abnormal_tumor_incidence1.47394072
56MP0005174_abnormal_tail_pigmentation1.38995567
57* MP0000350_abnormal_cell_proliferation1.38359695
58MP0000465_gastrointestinal_hemorrhage1.38109167
59MP0004947_skin_inflammation1.37196640
60MP0006292_abnormal_olfactory_placode1.34787190
61MP0003646_muscle_fatigue1.32502580
62MP0001853_heart_inflammation1.29293989
63MP0000569_abnormal_digit_pigmentation1.27079605
64MP0005171_absent_coat_pigmentation1.23321209
65MP0003890_abnormal_embryonic-extraembry1.20029802
66MP0006082_CNS_inflammation1.19320375
67MP0008932_abnormal_embryonic_tissue1.18080211
68MP0000858_altered_metastatic_potential1.17400681
69MP0003718_maternal_effect1.17318704
70MP0001730_embryonic_growth_arrest1.15312309
71* MP0000427_abnormal_hair_cycle1.14992148
72MP0000313_abnormal_cell_death1.12732864
73* MP0001845_abnormal_inflammatory_respons1.11485448
74MP0003448_altered_tumor_morphology1.10884594
75MP0002095_abnormal_skin_pigmentation1.10377644
76MP0005451_abnormal_body_composition1.06866391
77MP0001661_extended_life_span1.06552823
78MP0002933_joint_inflammation1.05907995
79MP0002877_abnormal_melanocyte_morpholog1.05505415
80* MP0002210_abnormal_sex_determination1.05106481
81MP0001929_abnormal_gametogenesis1.04326487
82MP0002084_abnormal_developmental_patter1.02804734
83MP0004233_abnormal_muscle_weight0.97960055
84MP0002938_white_spotting0.96505786
85MP0002085_abnormal_embryonic_tissue0.96487620
86MP0003566_abnormal_cell_adhesion0.96195994
87MP0003724_increased_susceptibility_to0.94657129
88MP0003866_abnormal_defecation0.94452240
89MP0002163_abnormal_gland_morphology0.92370821
90MP0003786_premature_aging0.92314795
91MP0001533_abnormal_skeleton_physiology0.91636698
92MP0008877_abnormal_DNA_methylation0.91112229
93MP0006035_abnormal_mitochondrial_morpho0.88729537
94MP0002086_abnormal_extraembryonic_tissu0.87576224
95MP0002009_preneoplasia0.87313031
96MP0003656_abnormal_erythrocyte_physiolo0.86533220
97MP0001145_abnormal_male_reproductive0.86522374
98MP0000358_abnormal_cell_content/0.85572027
99MP0002102_abnormal_ear_morphology0.85492136
100MP0001119_abnormal_female_reproductive0.84434724
101MP0002080_prenatal_lethality0.83392868
102MP0003123_paternal_imprinting0.83303152
103MP0005380_embryogenesis_phenotype0.83186621
104MP0001672_abnormal_embryogenesis/_devel0.83186621
105MP0001697_abnormal_embryo_size0.82890221
106MP0000015_abnormal_ear_pigmentation0.82457057
107MP0001346_abnormal_lacrimal_gland0.82142532
108MP0003984_embryonic_growth_retardation0.81921116
109MP0000653_abnormal_sex_gland0.81779896
110MP0003937_abnormal_limbs/digits/tail_de0.81102704
111MP0003705_abnormal_hypodermis_morpholog0.80184445
112MP0004147_increased_porphyrin_level0.80111331
113MP0002088_abnormal_embryonic_growth/wei0.79935055
114MP0005075_abnormal_melanosome_morpholog0.79615894
115MP0004381_abnormal_hair_follicle0.78564494
116MP0008469_abnormal_protein_level0.77979777
117MP0001915_intracranial_hemorrhage0.77510018
118MP0001293_anophthalmia0.77467687
119MP0005023_abnormal_wound_healing0.76870829
120MP0003221_abnormal_cardiomyocyte_apopto0.75859206
121* MP0004197_abnormal_fetal_growth/weight/0.75785724
122MP0001186_pigmentation_phenotype0.74369098
123MP0000428_abnormal_craniofacial_morphol0.74341317
124MP0009672_abnormal_birth_weight0.74077855
125MP0005266_abnormal_metabolism0.73043122
126MP0003806_abnormal_nucleotide_metabolis0.72669415
127MP0000371_diluted_coat_color0.72202223
128MP0003943_abnormal_hepatobiliary_system0.71445840
129MP0005384_cellular_phenotype0.71376756
130MP0005379_endocrine/exocrine_gland_phen0.70383858
131* MP0001286_abnormal_eye_development0.70245426
132MP0005310_abnormal_salivary_gland0.70072093
133MP0005621_abnormal_cell_physiology0.68820727
134MP0000477_abnormal_intestine_morphology0.67658791
135MP0009703_decreased_birth_body0.65381488
136MP0003121_genomic_imprinting0.65317559
137* MP0000647_abnormal_sebaceous_gland0.65098903
138MP0005253_abnormal_eye_physiology0.64847796
139MP0001324_abnormal_eye_pigmentation0.64832668
140MP0002075_abnormal_coat/hair_pigmentati0.63939761
141MP0003136_yellow_coat_color0.63043667
142MP0002132_abnormal_respiratory_system0.63040846
143MP0008995_early_reproductive_senescence0.62926457
144MP0003567_abnormal_fetal_cardiomyocyte0.62896697
145MP0005391_vision/eye_phenotype0.61984840
146MP0000733_abnormal_muscle_development0.61816020
147MP0002092_abnormal_eye_morphology0.61062133
148MP0003698_abnormal_male_reproductive0.60560011
149MP0004185_abnormal_adipocyte_glucose0.57385822

Predicted human phenotypes

RankGene SetZ-score
1Small intestinal stenosis (HP:0012848)3.80386672
2Duodenal stenosis (HP:0100867)3.80386672
3Nephroblastoma (Wilms tumor) (HP:0002667)3.71801162
4Recurrent viral infections (HP:0004429)3.58620802
5Embryonal renal neoplasm (HP:0011794)3.55524877
6Abnormality of the carotid arteries (HP:0005344)3.38703390
7Chromsome breakage (HP:0040012)3.23636736
8Sloping forehead (HP:0000340)3.21827002
9Recurrent abscess formation (HP:0002722)3.21034134
10Thrombocytosis (HP:0001894)3.20970386
11Chronic otitis media (HP:0000389)3.12166303
12Recurrent fungal infections (HP:0002841)3.11708563
13Abnormality of the duodenum (HP:0002246)3.08891393
14IgM deficiency (HP:0002850)3.02779436
15Reticulocytopenia (HP:0001896)2.96843328
16T lymphocytopenia (HP:0005403)2.91702543
17Abnormality of the fingertips (HP:0001211)2.90268156
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89273061
19Abnormality of T cell number (HP:0011839)2.89244863
20Eczematoid dermatitis (HP:0000976)2.89010958
21Duplicated collecting system (HP:0000081)2.86585551
22Myositis (HP:0100614)2.86222191
23Abnormality of chromosome stability (HP:0003220)2.82679227
24Elevated erythrocyte sedimentation rate (HP:0003565)2.82483632
25Cellulitis (HP:0100658)2.82469856
26Recurrent bronchitis (HP:0002837)2.81510568
27Recurrent bacterial skin infections (HP:0005406)2.80964669
28Abnormality of T cells (HP:0002843)2.69957018
29Autoimmune thrombocytopenia (HP:0001973)2.67335145
30Myelodysplasia (HP:0002863)2.56274472
31Cafe-au-lait spot (HP:0000957)2.54676592
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.53197288
33Birth length less than 3rd percentile (HP:0003561)2.52196620
34Abnormality of B cell number (HP:0010975)2.51565346
35B lymphocytopenia (HP:0010976)2.51565346
36Eosinophilia (HP:0001880)2.47839733
37Volvulus (HP:0002580)2.47415970
38Meningitis (HP:0001287)2.45150839
39Abnormal number of erythroid precursors (HP:0012131)2.45045607
40Abnormality of the renal collecting system (HP:0004742)2.44924689
41Glioma (HP:0009733)2.43191967
42Abnormality of T cell physiology (HP:0011840)2.42906634
43Abnormality of cells of the erythroid lineage (HP:0012130)2.41893605
44Panhypogammaglobulinemia (HP:0003139)2.40902301
45Mediastinal lymphadenopathy (HP:0100721)2.39526376
46Acute myeloid leukemia (HP:0004808)2.37949636
47Lymphoma (HP:0002665)2.35423446
48Abnormality of chromosome segregation (HP:0002916)2.34563952
4911 pairs of ribs (HP:0000878)2.34502805
50Abnormal lung lobation (HP:0002101)2.33860739
51IgA deficiency (HP:0002720)2.33067414
52Colon cancer (HP:0003003)2.32803390
53IgG deficiency (HP:0004315)2.32074220
54Granulocytopenia (HP:0001913)2.28802930
55Poikiloderma (HP:0001029)2.26840869
56Petechiae (HP:0000967)2.25069775
57Triphalangeal thumb (HP:0001199)2.24732394
58Periodontitis (HP:0000704)2.24086347
59Agammaglobulinemia (HP:0004432)2.22374989
60Abnormality of the astrocytes (HP:0100707)2.21980836
61Astrocytoma (HP:0009592)2.21980836
62Thyroiditis (HP:0100646)2.20571079
63Short thumb (HP:0009778)2.19363743
64Embryonal neoplasm (HP:0002898)2.19153600
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.18269516
66Cerebellar dysplasia (HP:0007033)2.18156062
67Vasculitis (HP:0002633)2.17981779
68Pustule (HP:0200039)2.16381524
69Rhabdomyosarcoma (HP:0002859)2.14754369
70Absent thumb (HP:0009777)2.14611963
71Amaurosis fugax (HP:0100576)2.14368219
72Abnormality of the preputium (HP:0100587)2.13888727
73Ependymoma (HP:0002888)2.11884194
74Obstructive lung disease (HP:0006536)2.11818890
75Chronic obstructive pulmonary disease (HP:0006510)2.11818890
76Lymphopenia (HP:0001888)2.11571012
77Osteomyelitis (HP:0002754)2.11435441
78Chronic mucocutaneous candidiasis (HP:0002728)2.11336730
79Recurrent cutaneous fungal infections (HP:0011370)2.11336730
80Nasal polyposis (HP:0100582)2.11142006
81Combined immunodeficiency (HP:0005387)2.09869891
82Arteriovenous malformation (HP:0100026)2.06906876
83Absent radius (HP:0003974)2.06672426
84Medulloblastoma (HP:0002885)2.06486958
85Optic neuritis (HP:0100653)2.06131895
86Retrobulbar optic neuritis (HP:0100654)2.06131895
87Patellar aplasia (HP:0006443)2.06124104
88Leukocytosis (HP:0001974)2.05536190
89High pitched voice (HP:0001620)2.05399581
90Abnormality of the prostate (HP:0008775)2.04029235
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.03852662
92Entropion (HP:0000621)2.03816554
93Orchitis (HP:0100796)2.02578328
94Abnormality of eosinophils (HP:0001879)2.02560841
95Abnormal platelet volume (HP:0011876)2.01236408
96Severe combined immunodeficiency (HP:0004430)2.01224497
97Ectopic kidney (HP:0000086)2.01088941
98Osteolytic defects of the hand bones (HP:0009699)1.99647022
99Osteolytic defects of the phalanges of the hand (HP:0009771)1.99647022
100Clubbing of toes (HP:0100760)1.98661658
101Prolonged bleeding time (HP:0003010)1.98549329
102Selective tooth agenesis (HP:0001592)1.97710087
103Recurrent skin infections (HP:0001581)1.96568798
104Prominent nose (HP:0000448)1.96188350
105Papilloma (HP:0012740)1.95701215
106Verrucae (HP:0200043)1.95701215
107Astigmatism (HP:0000483)1.94691624
108Abnormality of DNA repair (HP:0003254)1.94517227
109Absent forearm bone (HP:0003953)1.94299970
110Aplasia involving forearm bones (HP:0009822)1.94299970
111Agnosia (HP:0010524)1.93356252
112Meckel diverticulum (HP:0002245)1.92912518
113Basal cell carcinoma (HP:0002671)1.91571791
114Prostate neoplasm (HP:0100787)1.91028641
115Gastrointestinal inflammation (HP:0004386)1.89629160
116Hypopigmentation of the fundus (HP:0007894)1.89298441
117Inflammation of the large intestine (HP:0002037)1.89036245
118Pallor (HP:0000980)1.88252685
119Sandal gap (HP:0001852)1.88247485
120Bone marrow hypocellularity (HP:0005528)1.87751251
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87693172
122Short 4th metacarpal (HP:0010044)1.87693172
123Acute lymphatic leukemia (HP:0006721)1.87679813
124Aplasia/Hypoplasia of the patella (HP:0006498)1.87534258
125Choanal atresia (HP:0000453)1.86664184
126Heterotopia (HP:0002282)1.86461088
127Facial hemangioma (HP:0000329)1.86384011
128Cutaneous melanoma (HP:0012056)1.86179672
129Absent frontal sinuses (HP:0002688)1.86150763
130Increased nuchal translucency (HP:0010880)1.84411822
131Poor speech (HP:0002465)1.82924468
132Pancytopenia (HP:0001876)1.81569753
133Abnormality of the ileum (HP:0001549)1.81532337
134Deep philtrum (HP:0002002)1.81462477
135Poor head control (HP:0002421)1.80951390
136Recurrent pneumonia (HP:0006532)1.80823710
137Squamous cell carcinoma (HP:0002860)1.80649341
138Neoplasm of the adrenal cortex (HP:0100641)1.80348500
139Autoimmune hemolytic anemia (HP:0001890)1.79799052
140Deviation of the thumb (HP:0009603)1.79582536
141Aplastic anemia (HP:0001915)1.78494965
142Spontaneous hematomas (HP:0007420)1.78258885
143Abnormality of the parathyroid morphology (HP:0011766)1.78040827
144Cortical dysplasia (HP:0002539)1.77561721
145Long clavicles (HP:0000890)1.75904827
146Autoamputation (HP:0001218)1.72630050
147Hypoplastic iliac wings (HP:0002866)1.69579958
148Neoplasm of the colon (HP:0100273)1.68958017
149Small hand (HP:0200055)1.67795115
150Abnormality of the pons (HP:0007361)1.62002300
151Overlapping toe (HP:0001845)1.61347367
152Oligodactyly (hands) (HP:0001180)1.60680002
153Breast hypoplasia (HP:0003187)1.59938176
154Microtia (HP:0008551)1.58699974
155Renal cortical cysts (HP:0000803)1.58346972
156Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57186201
157Impulsivity (HP:0100710)1.56719543
158Abnormality of the labia minora (HP:0012880)1.56309005
159Missing ribs (HP:0000921)1.56247193
160Progressive inability to walk (HP:0002505)1.56238874
161Partial agenesis of the corpus callosum (HP:0001338)1.55485900
162Neoplasm of striated muscle (HP:0009728)1.55277794
163Horseshoe kidney (HP:0000085)1.54265073
164Oligohydramnios (HP:0001562)1.53018003
165Proximal placement of thumb (HP:0009623)1.52943382
166Fair hair (HP:0002286)1.52410445
167Microglossia (HP:0000171)1.50869241
168Capillary hemangiomas (HP:0005306)1.49558207
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.49325376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.70021686
2MAP4K13.05684261
3NEK12.73983573
4EEF2K2.58910998
5NEK22.41143807
6STK102.35116920
7JAK32.22872633
8PBK2.22826197
9WEE12.20816028
10TAF12.20477541
11MAP3K102.18106012
12PKN22.08314857
13BMPR1B2.06747133
14KIT1.85492726
15TYK21.83525783
16STK41.83347474
17RPS6KA41.74840141
18PNCK1.74231757
19MAP3K141.73950472
20VRK21.72562084
21ACVR1B1.69062227
22FRK1.68024127
23CDK81.65371936
24TXK1.63920880
25NUAK11.62599291
26CDK121.61939384
27ATR1.58575769
28BUB11.56320211
29BTK1.51036599
30RPS6KB21.49049483
31EIF2AK11.47917810
32FLT31.43997313
33IRAK41.43069486
34LRRK21.41747409
35TBK11.41634233
36CSF1R1.35311952
37SRPK11.34796642
38PIM11.33241391
39CLK11.32785721
40TTK1.31180454
41AURKB1.30119483
42TRIM281.29477950
43BRSK21.28436881
44CDK61.27285971
45NME21.26886305
46TRIB31.24307343
47SCYL21.24269336
48ZAP701.24026132
49* CDK41.22563085
50IKBKE1.19673619
51STK31.18908718
52TEC1.16999999
53PASK1.16856816
54MKNK11.16824668
55MAP3K81.13319869
56SYK1.10803635
57IKBKB1.08635681
58GRK61.07858609
59TGFBR11.05320920
60PLK11.04803765
61TRPM71.03645271
62PLK41.02145073
63NEK90.97063464
64BLK0.96729350
65DYRK30.96521986
66CHUK0.94669542
67CDK70.94001275
68FGFR30.92681097
69JAK10.92062271
70LATS10.91169691
71CHEK20.90780249
72SMG10.86977473
73VRK10.86062136
74LCK0.85261441
75CHEK10.84241100
76ITK0.83916318
77MAP2K30.83315857
78TLK10.82221987
79PTK60.79525066
80EIF2AK30.78505898
81ERBB30.77483614
82AURKA0.77281196
83ATM0.76822201
84MKNK20.76003772
85BRSK10.75161558
86TTN0.74830518
87MST40.74562348
88LYN0.74342941
89EIF2AK20.72625983
90CCNB10.71459806
91CSK0.71414702
92BRD40.70153122
93PLK20.68847528
94MELK0.68771156
95HCK0.67309213
96CDK10.66065972
97PAK40.65559085
98TGFBR20.64120879
99MARK30.63811025
100ZAK0.62897176
101STK240.62710791
102FGFR40.60157775
103WNK30.58401218
104RPS6KA50.55841347
105MAP3K130.55196585
106CDK90.54765867
107NLK0.54552666
108SIK20.54304919
109ERN10.54105989
110* CDK20.52459671
111YES10.49539825
112PIM20.48669662
113TESK20.48359570
114MST1R0.48356530
115TSSK60.48030111
116MAPKAPK20.47193362
117MAPK110.47183157
118CAMKK20.46964598
119PLK30.46851042
120INSRR0.46833549
121SIK30.46725781
122BMPR20.45586023
123ERBB40.43890022
124BCR0.42232391
125STK38L0.40444063
126PIK3CG0.39640869
127CAMK1G0.37311535
128CDK30.36999512
129OBSCN0.35801511
130CSNK1A1L0.34190487
131CSNK2A20.34184314
132CSNK2A10.31296847
133PRKDC0.29546127
134TNIK0.28500786
135* MAPK140.21903800
136TAOK30.21397213
137MAPKAPK50.21279198
138PDK20.19774655
139CSNK1G10.19372150
140MET0.17492459
141AKT10.17453761
142CSNK1G30.17100657
143CSNK1E0.16883372
144FGFR10.16574483

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.03622362
2Mismatch repair_Homo sapiens_hsa034303.06159144
3Base excision repair_Homo sapiens_hsa034102.51045229
4Homologous recombination_Homo sapiens_hsa034402.44301848
5* Cell cycle_Homo sapiens_hsa041102.26587436
6Primary immunodeficiency_Homo sapiens_hsa053402.25092658
7Non-homologous end-joining_Homo sapiens_hsa034502.14206271
8Spliceosome_Homo sapiens_hsa030401.93816178
9Fanconi anemia pathway_Homo sapiens_hsa034601.91054076
10Nucleotide excision repair_Homo sapiens_hsa034201.89133580
11Measles_Homo sapiens_hsa051621.85369238
12Herpes simplex infection_Homo sapiens_hsa051681.83790818
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.81644042
14Antigen processing and presentation_Homo sapiens_hsa046121.77155531
15One carbon pool by folate_Homo sapiens_hsa006701.75771446
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.75175566
17Leishmaniasis_Homo sapiens_hsa051401.74445492
18Ribosome_Homo sapiens_hsa030101.71525969
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65525262
20RNA transport_Homo sapiens_hsa030131.60945676
21p53 signaling pathway_Homo sapiens_hsa041151.58936507
22Allograft rejection_Homo sapiens_hsa053301.57060350
23Systemic lupus erythematosus_Homo sapiens_hsa053221.55042958
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50779247
25B cell receptor signaling pathway_Homo sapiens_hsa046621.45847127
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45146334
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36075934
28Hematopoietic cell lineage_Homo sapiens_hsa046401.35674301
29* Viral carcinogenesis_Homo sapiens_hsa052031.34564843
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31985316
31Legionellosis_Homo sapiens_hsa051341.31549105
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29949817
33Influenza A_Homo sapiens_hsa051641.28019021
34Osteoclast differentiation_Homo sapiens_hsa043801.27902685
35Hepatitis B_Homo sapiens_hsa051611.27166030
36Selenocompound metabolism_Homo sapiens_hsa004501.22242751
37Small cell lung cancer_Homo sapiens_hsa052221.21514466
38Apoptosis_Homo sapiens_hsa042101.20828118
39Chronic myeloid leukemia_Homo sapiens_hsa052201.20005142
40RNA degradation_Homo sapiens_hsa030181.17693315
41Viral myocarditis_Homo sapiens_hsa054161.16564051
42Epstein-Barr virus infection_Homo sapiens_hsa051691.16556266
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16433454
44Toxoplasmosis_Homo sapiens_hsa051451.15987521
45Pyrimidine metabolism_Homo sapiens_hsa002401.15232685
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12841564
47Graft-versus-host disease_Homo sapiens_hsa053321.12698373
48HTLV-I infection_Homo sapiens_hsa051661.12285092
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09925461
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.08362061
51Shigellosis_Homo sapiens_hsa051311.08276512
52Oocyte meiosis_Homo sapiens_hsa041141.07907317
53Protein export_Homo sapiens_hsa030601.04309246
54T cell receptor signaling pathway_Homo sapiens_hsa046601.02828923
55mRNA surveillance pathway_Homo sapiens_hsa030151.01530014
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99957154
57TNF signaling pathway_Homo sapiens_hsa046680.95968991
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95793350
59Acute myeloid leukemia_Homo sapiens_hsa052210.93876447
60Pancreatic cancer_Homo sapiens_hsa052120.92526523
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91851279
62MicroRNAs in cancer_Homo sapiens_hsa052060.91446949
63Autoimmune thyroid disease_Homo sapiens_hsa053200.89428177
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89262730
65Asthma_Homo sapiens_hsa053100.85173222
66Malaria_Homo sapiens_hsa051440.84336312
67Propanoate metabolism_Homo sapiens_hsa006400.84265274
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83970612
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.83361640
70Proteasome_Homo sapiens_hsa030500.82150689
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79354352
72Tuberculosis_Homo sapiens_hsa051520.77958210
73Pertussis_Homo sapiens_hsa051330.76995665
74RNA polymerase_Homo sapiens_hsa030200.76483188
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74057242
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.73595046
77Chemokine signaling pathway_Homo sapiens_hsa040620.72376710
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70444241
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70375499
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68783510
81Basal transcription factors_Homo sapiens_hsa030220.68305744
82Hepatitis C_Homo sapiens_hsa051600.68085951
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67918655
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66389704
85Colorectal cancer_Homo sapiens_hsa052100.65888162
86Platelet activation_Homo sapiens_hsa046110.64414032
87Non-small cell lung cancer_Homo sapiens_hsa052230.64302113
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60103552
89Thyroid cancer_Homo sapiens_hsa052160.56555016
90Steroid biosynthesis_Homo sapiens_hsa001000.55926921
91Type I diabetes mellitus_Homo sapiens_hsa049400.51910263
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51557185
93Salmonella infection_Homo sapiens_hsa051320.51143045
94Notch signaling pathway_Homo sapiens_hsa043300.50881216
95Prostate cancer_Homo sapiens_hsa052150.50079172
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48812814
97Prolactin signaling pathway_Homo sapiens_hsa049170.48361874
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47198247
99N-Glycan biosynthesis_Homo sapiens_hsa005100.45662705
100Renin-angiotensin system_Homo sapiens_hsa046140.45354208
101HIF-1 signaling pathway_Homo sapiens_hsa040660.44654723
102Purine metabolism_Homo sapiens_hsa002300.42649464
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42103692
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.40971730
105FoxO signaling pathway_Homo sapiens_hsa040680.40752232
106Pathways in cancer_Homo sapiens_hsa052000.39078087
107Biosynthesis of amino acids_Homo sapiens_hsa012300.38914755
108Proteoglycans in cancer_Homo sapiens_hsa052050.38044229
109Melanoma_Homo sapiens_hsa052180.37008331
110Alcoholism_Homo sapiens_hsa050340.36883323
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36753921
112Pentose phosphate pathway_Homo sapiens_hsa000300.35746922
113mTOR signaling pathway_Homo sapiens_hsa041500.34499872
114Staphylococcus aureus infection_Homo sapiens_hsa051500.32826527
115Lysine degradation_Homo sapiens_hsa003100.31694519
116Bladder cancer_Homo sapiens_hsa052190.30695668
117Pyruvate metabolism_Homo sapiens_hsa006200.29352348
118Adherens junction_Homo sapiens_hsa045200.28396861
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26405389
120Glioma_Homo sapiens_hsa052140.26045206
121Inositol phosphate metabolism_Homo sapiens_hsa005620.25796881
122Regulation of autophagy_Homo sapiens_hsa041400.25375237
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24666711
124Basal cell carcinoma_Homo sapiens_hsa052170.22742544
125Carbon metabolism_Homo sapiens_hsa012000.21277336
126Glutathione metabolism_Homo sapiens_hsa004800.19003894
127Hippo signaling pathway_Homo sapiens_hsa043900.18393573
128Nitrogen metabolism_Homo sapiens_hsa009100.18334865
129Fatty acid biosynthesis_Homo sapiens_hsa000610.17997257
130* TGF-beta signaling pathway_Homo sapiens_hsa043500.16474872
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14979379
132Fatty acid metabolism_Homo sapiens_hsa012120.14941429
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14344497
134Olfactory transduction_Homo sapiens_hsa047400.14181044
135Butanoate metabolism_Homo sapiens_hsa006500.13886522
136Huntingtons disease_Homo sapiens_hsa050160.13444193
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13165342
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12430532
139Metabolic pathways_Homo sapiens_hsa011000.12392976
140Fatty acid elongation_Homo sapiens_hsa000620.09572555
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09301687
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09196972
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.08577176
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08547972

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