RBL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.26677384
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26677384
3positive regulation of gamma-delta T cell activation (GO:0046645)4.99578310
4antigen processing and presentation of endogenous antigen (GO:0019883)4.67267388
5negative regulation of lymphocyte mediated immunity (GO:0002707)4.35345095
6negative T cell selection (GO:0043383)4.33765547
7regulation of gamma-delta T cell differentiation (GO:0045586)4.30707709
8negative regulation of T cell mediated immunity (GO:0002710)4.27782850
9negative thymic T cell selection (GO:0045060)4.25161013
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00409434
11detection of other organism (GO:0098543)3.91568134
12regulation of gamma-delta T cell activation (GO:0046643)3.90849322
13B cell receptor signaling pathway (GO:0050853)3.89741034
14positive regulation of granulocyte differentiation (GO:0030854)3.85752815
15positive regulation by symbiont of host defense response (GO:0052509)3.80987133
16modulation by symbiont of host defense response (GO:0052031)3.80987133
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80987133
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80987133
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.80987133
20modulation by symbiont of host immune response (GO:0052553)3.80987133
21cellular extravasation (GO:0045123)3.80777060
22response to interleukin-15 (GO:0070672)3.74736560
23negative regulation of leukocyte mediated immunity (GO:0002704)3.74530603
24detection of bacterium (GO:0016045)3.72842440
25valine metabolic process (GO:0006573)3.53031827
26regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.52612472
27negative regulation of cell killing (GO:0031342)3.52489235
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52489235
29alpha-linolenic acid metabolic process (GO:0036109)3.47690942
30histone H3-K36 demethylation (GO:0070544)3.43316716
31positive thymic T cell selection (GO:0045059)3.42508791
32tolerance induction (GO:0002507)3.34172032
33thymic T cell selection (GO:0045061)3.33334397
34detection of external biotic stimulus (GO:0098581)3.31476946
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29253638
36macrophage activation involved in immune response (GO:0002281)3.26971104
37negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.25387701
38T cell selection (GO:0045058)3.24393006
39response to muramyl dipeptide (GO:0032495)3.20547154
40cellular response to interleukin-15 (GO:0071350)3.19536673
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17828426
42antigen receptor-mediated signaling pathway (GO:0050851)3.15667262
43neutrophil activation involved in immune response (GO:0002283)3.13154512
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12085483
45positive T cell selection (GO:0043368)3.11716978
46detection of molecule of bacterial origin (GO:0032490)3.11346004
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09097429
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.05759976
49L-phenylalanine catabolic process (GO:0006559)3.05759976
50phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.04052376
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01205928
52negative regulation of adaptive immune response (GO:0002820)2.99568079
53regulation of B cell receptor signaling pathway (GO:0050855)2.94787198
54regulation of T cell tolerance induction (GO:0002664)2.93996948
55regulation of isotype switching to IgG isotypes (GO:0048302)2.93636787
56regulation of granulocyte differentiation (GO:0030852)2.93425741
57negative regulation of interleukin-12 production (GO:0032695)2.92446800
58carnitine metabolic process (GO:0009437)2.92340022
59mast cell activation (GO:0045576)2.90163213
60antigen processing and presentation via MHC class Ib (GO:0002475)2.89341262
61amino-acid betaine metabolic process (GO:0006577)2.88900286
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86949495
63negative regulation of T-helper cell differentiation (GO:0045623)2.86938710
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86938710
65regulation of interferon-beta biosynthetic process (GO:0045357)2.86912257
66response to type I interferon (GO:0034340)2.86261027
67type I interferon signaling pathway (GO:0060337)2.86149004
68cellular response to type I interferon (GO:0071357)2.86149004
69microglial cell activation (GO:0001774)2.85596841
70T cell migration (GO:0072678)2.85179143
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84740799
72detection of biotic stimulus (GO:0009595)2.84135347
73positive regulation of B cell differentiation (GO:0045579)2.82482144
74dendritic cell migration (GO:0036336)2.81550838
75neutrophil activation (GO:0042119)2.81536871
76positive regulation of histone deacetylation (GO:0031065)2.78152816
77positive regulation of natural killer cell differentiation (GO:0032825)2.76886217
78positive regulation of tolerance induction (GO:0002645)2.76382022
79negative regulation of glycoprotein biosynthetic process (GO:0010561)2.75727801
80myeloid cell activation involved in immune response (GO:0002275)2.75446818
81interferon-gamma production (GO:0032609)2.74295210
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73604697
83response to host immune response (GO:0052572)2.73604697
84respiratory burst (GO:0045730)2.72937976
85negative regulation of innate immune response (GO:0045824)2.72407068
86dendritic cell chemotaxis (GO:0002407)2.72208165
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.72156130
88L-phenylalanine metabolic process (GO:0006558)2.72156130
89T cell costimulation (GO:0031295)2.72092412
90T cell homeostasis (GO:0043029)2.71832193
91lymphocyte costimulation (GO:0031294)2.71533591
92positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70595788
93leukocyte aggregation (GO:0070486)2.69548860
94negative regulation of type 2 immune response (GO:0002829)2.68396022
952-oxoglutarate metabolic process (GO:0006103)2.68170712
96response to host (GO:0075136)2.67062334
97response to host defenses (GO:0052200)2.67062334
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67062334
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.66666055
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.66191427
101aromatic amino acid family catabolic process (GO:0009074)2.65821826
102growth hormone receptor signaling pathway (GO:0060396)2.64251926
103short-chain fatty acid metabolic process (GO:0046459)2.63760454
104dicarboxylic acid biosynthetic process (GO:0043650)2.59102177
105regulation of B cell differentiation (GO:0045577)2.58989218
106peptidyl-glutamic acid carboxylation (GO:0017187)2.58977570
107protein carboxylation (GO:0018214)2.58977570
108lysine metabolic process (GO:0006553)2.58067552
109lysine catabolic process (GO:0006554)2.58067552
110cysteine metabolic process (GO:0006534)2.56673165
111ethanol oxidation (GO:0006069)2.56251438
112tricarboxylic acid metabolic process (GO:0072350)2.56209893
113regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.54917290
114regulation of natural killer cell mediated immunity (GO:0002715)2.54917290
115regulation of regulatory T cell differentiation (GO:0045589)2.52208521
116activated T cell proliferation (GO:0050798)2.51237190
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.50754335
118negative regulation of erythrocyte differentiation (GO:0045647)2.50393506
119bile acid biosynthetic process (GO:0006699)2.47900509
120regulation of alpha-beta T cell proliferation (GO:0046640)2.47744389
121regulation of triglyceride catabolic process (GO:0010896)2.45920129
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.44518079
123regulation of cholesterol homeostasis (GO:2000188)2.42930875
124creatine metabolic process (GO:0006600)2.42824997
125regulation of tolerance induction (GO:0002643)2.42453346
126regulation of fatty acid beta-oxidation (GO:0031998)2.41707030
127Peyers patch development (GO:0048541)2.41619642
128mucosal-associated lymphoid tissue development (GO:0048537)2.41619642
129positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41068079
130positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.40905247
131positive regulation of natural killer cell mediated immunity (GO:0002717)2.40905247
132regulation of ARF protein signal transduction (GO:0032012)2.37056163
133complement activation, alternative pathway (GO:0006957)2.36067674
134kynurenine metabolic process (GO:0070189)2.35491331
135positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.34887778
136cellular response to growth hormone stimulus (GO:0071378)2.34331047
137megakaryocyte development (GO:0035855)2.31510938
138tryptophan catabolic process (GO:0006569)2.30565705
139indole-containing compound catabolic process (GO:0042436)2.30565705
140indolalkylamine catabolic process (GO:0046218)2.30565705
141T cell receptor signaling pathway (GO:0050852)2.30472687
142fatty acid beta-oxidation (GO:0006635)2.29159429
143regulation of leukocyte mediated cytotoxicity (GO:0001910)2.28535068
144natural killer cell differentiation (GO:0001779)2.27459484
145lipid oxidation (GO:0034440)2.26956835
146fatty acid oxidation (GO:0019395)2.25659403
147positive regulation of alpha-beta T cell proliferation (GO:0046641)2.25402423
148urea cycle (GO:0000050)2.25344039
149urea metabolic process (GO:0019627)2.25344039
150regulation of T cell mediated cytotoxicity (GO:0001914)2.24540680
151positive regulation of interleukin-2 production (GO:0032743)2.22563527
152phospholipid homeostasis (GO:0055091)2.22144597
153drug transmembrane transport (GO:0006855)2.21949622
154regulation of natural killer cell differentiation (GO:0032823)2.21303307
155tryptophan metabolic process (GO:0006568)2.18880744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.95557695
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.47326391
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.71572955
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.47201602
5* RUNX_20019798_ChIP-Seq_JUKART_Human3.10037831
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.77826049
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.54079734
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49799326
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48076233
10SCL_19346495_ChIP-Seq_HPC-7_Human2.37896545
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36617005
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.33257110
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32979953
14* SPI1_23547873_ChIP-Seq_NB4_Human2.04179938
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.04046444
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02996264
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01189948
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00688158
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99136018
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87909101
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86387135
22MYB_26560356_Chip-Seq_TH2_Human1.85637641
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.82874317
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82870217
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.80223670
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76563864
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75773427
28MAF_26560356_Chip-Seq_TH1_Human1.71606402
29GATA1_22025678_ChIP-Seq_K562_Human1.69345848
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.66668613
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66541271
32* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63678214
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62473819
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59549079
35MYB_26560356_Chip-Seq_TH1_Human1.58450104
36TCF7_22412390_ChIP-Seq_EML_Mouse1.50164160
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.47977450
38GATA3_27048872_Chip-Seq_THYMUS_Human1.47284532
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47205964
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.44497259
41SPI1_23127762_ChIP-Seq_K562_Human1.42868106
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42306194
43UTX_26944678_Chip-Seq_JUKART_Human1.37076531
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35878603
45GATA1_19941826_ChIP-Seq_K562_Human1.34790989
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31296614
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.29552062
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29138876
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26415219
50GATA2_19941826_ChIP-Seq_K562_Human1.25237085
51* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25184814
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24862928
53* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24155807
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23649814
55VDR_24787735_ChIP-Seq_THP-1_Human1.22970566
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.22415167
57VDR_24763502_ChIP-Seq_THP-1_Human1.18011643
58PU_27001747_Chip-Seq_BMDM_Mouse1.14636846
59* FOXO3_23340844_ChIP-Seq_DLD1_Human1.12595216
60* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12565298
61MYC_22102868_ChIP-Seq_BL_Human1.12458845
62CLOCK_20551151_ChIP-Seq_293T_Human1.12121209
63GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12057161
64* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11172568
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10804985
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.10462798
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10006706
68* KDM2B_26808549_Chip-Seq_DND41_Human1.09035244
69* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08858939
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08565522
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07812039
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06907155
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06729547
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04838352
75VDR_21846776_ChIP-Seq_THP-1_Human1.04613028
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04414432
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03675769
78DROSHA_22980978_ChIP-Seq_HELA_Human1.03564865
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03557176
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02898596
81GATA3_26560356_Chip-Seq_TH2_Human1.02277816
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00871996
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99435060
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98641788
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98379928
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98241238
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97170823
88* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96030806
89CIITA_25753668_ChIP-Seq_RAJI_Human0.94284598
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94025964
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.93851873
92AR_21572438_ChIP-Seq_LNCaP_Human0.92113590
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92059835
94RXR_22108803_ChIP-Seq_LS180_Human0.91180915
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90787274
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90657273
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90538194
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.88727918
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.88727918
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87304399
101MAF_26560356_Chip-Seq_TH2_Human0.87018431
102SMRT_27268052_Chip-Seq_Bcells_Human0.84829807
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83849707
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83807509
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83664918
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83562798
107* ELK3_25401928_ChIP-Seq_HUVEC_Human0.83467488
108ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82144695
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.81535289
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80858266
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80606650
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79836627
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79744326
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78426098
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77124786
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76411260
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75431518
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74440582
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73073181
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72364843
121NCOR1_26117541_ChIP-Seq_K562_Human0.71085218
122* ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70625354
123* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68828041
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66073325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.23880371
2MP0005360_urolithiasis2.81879749
3MP0005365_abnormal_bile_salt2.81464900
4MP0000685_abnormal_immune_system2.79978234
5MP0002166_altered_tumor_susceptibility2.79069334
6MP0003300_gastrointestinal_ulcer2.76922796
7MP0001835_abnormal_antigen_presentation2.61528651
8MP0005671_abnormal_response_to2.59989765
9MP0003763_abnormal_thymus_physiology2.51743698
10MP0005085_abnormal_gallbladder_physiolo2.35508860
11MP0001873_stomach_inflammation2.28128872
12MP0003252_abnormal_bile_duct2.26024394
13MP0004130_abnormal_muscle_cell2.21490986
14MP0002138_abnormal_hepatobiliary_system2.18911797
15MP0005387_immune_system_phenotype2.17430959
16MP0001790_abnormal_immune_system2.17430959
17MP0008875_abnormal_xenobiotic_pharmacok2.11688856
18MP0001800_abnormal_humoral_immune2.10330885
19MP0008260_abnormal_autophagy2.01706472
20MP0004381_abnormal_hair_follicle1.93510376
21MP0010329_abnormal_lipoprotein_level1.91070714
22MP0002006_tumorigenesis1.82322389
23MP0009333_abnormal_splenocyte_physiolog1.80874066
24MP0009840_abnormal_foam_cell1.79724452
25MP0005464_abnormal_platelet_physiology1.73398857
26MP0006082_CNS_inflammation1.72360912
27MP0002723_abnormal_immune_serum1.71299905
28MP0009780_abnormal_chondrocyte_physiolo1.67486484
29MP0005025_abnormal_response_to1.67411384
30MP0003828_pulmonary_edema1.67361642
31MP0003690_abnormal_glial_cell1.67229737
32MP0005000_abnormal_immune_tolerance1.66359995
33MP0002452_abnormal_antigen_presenting1.65796061
34MP0001853_heart_inflammation1.65790731
35MP0002420_abnormal_adaptive_immunity1.65487413
36MP0002419_abnormal_innate_immunity1.63465970
37MP0001819_abnormal_immune_cell1.62376886
38MP0003724_increased_susceptibility_to1.59290147
39MP0004947_skin_inflammation1.57085482
40MP0009785_altered_susceptibility_to1.56464329
41MP0010155_abnormal_intestine_physiology1.51038187
42MP0003436_decreased_susceptibility_to1.50794989
43MP0005451_abnormal_body_composition1.47519618
44MP0004883_abnormal_blood_vessel1.44353168
45MP0003183_abnormal_peptide_metabolism1.43633302
46MP0002398_abnormal_bone_marrow1.43581217
47MP0000609_abnormal_liver_physiology1.42906697
48MP0003303_peritoneal_inflammation1.42778804
49MP0003191_abnormal_cellular_cholesterol1.41440652
50MP0005310_abnormal_salivary_gland1.40529967
51MP0001666_abnormal_nutrient_absorption1.39559317
52MP0000858_altered_metastatic_potential1.37363696
53MP0002009_preneoplasia1.36911813
54MP0005332_abnormal_amino_acid1.34671796
55MP0000716_abnormal_immune_system1.34544429
56MP0005584_abnormal_enzyme/coenzyme_acti1.34243952
57MP0003866_abnormal_defecation1.32537550
58MP0001845_abnormal_inflammatory_respons1.28533868
59MP0002118_abnormal_lipid_homeostasis1.28478575
60MP0009384_cardiac_valve_regurgitation1.27862102
61MP0002132_abnormal_respiratory_system1.26867500
62MP0003868_abnormal_feces_composition1.25802382
63MP0003045_fibrosis1.23994324
64MP0000465_gastrointestinal_hemorrhage1.23309871
65MP0009764_decreased_sensitivity_to1.22521326
66MP0000689_abnormal_spleen_morphology1.21170736
67MP0008469_abnormal_protein_level1.20242241
68MP0000920_abnormal_myelination1.16114443
69MP0002396_abnormal_hematopoietic_system1.15985042
70MP0004510_myositis1.15656351
71MP0005058_abnormal_lysosome_morphology1.15611171
72MP0002405_respiratory_system_inflammati1.13436308
73MP0003172_abnormal_lysosome_physiology1.13400349
74MP0002722_abnormal_immune_system1.13338436
75MP0002928_abnormal_bile_duct1.13234090
76MP0003656_abnormal_erythrocyte_physiolo1.09253778
77MP0003075_altered_response_to1.08146484
78MP0008961_abnormal_basal_metabolism1.07974460
79MP0005670_abnormal_white_adipose1.06864025
80MP0002933_joint_inflammation1.05430322
81MP0003806_abnormal_nucleotide_metabolis1.03517477
82MP0003279_aneurysm1.01567925
83MP0002429_abnormal_blood_cell1.00645029
84MP0000604_amyloidosis0.99562934
85MP0005319_abnormal_enzyme/_coenzyme0.99405442
86MP0005164_abnormal_response_to0.98970273
87MP0001533_abnormal_skeleton_physiology0.97969559
88MP0000703_abnormal_thymus_morphology0.97948563
89MP0002148_abnormal_hypersensitivity_rea0.97603174
90MP0003091_abnormal_cell_migration0.97128381
91MP0009278_abnormal_bone_marrow0.96255762
92MP0009643_abnormal_urine_homeostasis0.94507308
93MP0002998_abnormal_bone_remodeling0.93254808
94MP0004808_abnormal_hematopoietic_stem0.93184250
95MP0005083_abnormal_biliary_tract0.92680648
96MP0000569_abnormal_digit_pigmentation0.88966727
97MP0009763_increased_sensitivity_to0.87131451
98MP0000015_abnormal_ear_pigmentation0.84117509
99MP0005166_decreased_susceptibility_to0.83498883
100MP0000249_abnormal_blood_vessel0.81843514
101MP0004484_altered_response_of0.81675272
102MP0008057_abnormal_DNA_replication0.79857906
103MP0001545_abnormal_hematopoietic_system0.79841993
104MP0005397_hematopoietic_system_phenotyp0.79841993
105MP0005666_abnormal_adipose_tissue0.79800586
106MP0005334_abnormal_fat_pad0.77347636
107MP0001958_emphysema0.77343060
108MP0001851_eye_inflammation0.76875965
109MP0001764_abnormal_homeostasis0.76311072
110MP0004264_abnormal_extraembryonic_tissu0.74724961
111MP0009765_abnormal_xenobiotic_induced0.74380648
112MP0003448_altered_tumor_morphology0.74352954
113MP0006054_spinal_hemorrhage0.73987166
114MP0001765_abnormal_ion_homeostasis0.73703717
115MP0005075_abnormal_melanosome_morpholog0.73330328
116MP0002971_abnormal_brown_adipose0.73311087
117MP0002277_abnormal_respiratory_mucosa0.73151019
118MP0008874_decreased_physiological_sensi0.72086261
119MP0000598_abnormal_liver_morphology0.69358532
120MP0008004_abnormal_stomach_pH0.67898722
121MP0009115_abnormal_fat_cell0.67512232
122MP0001663_abnormal_digestive_system0.67045785
123MP0003221_abnormal_cardiomyocyte_apopto0.66572245
124MP0005388_respiratory_system_phenotype0.65108431
125MP0002133_abnormal_respiratory_system0.65108431
126MP0001986_abnormal_taste_sensitivity0.63549951
127MP0002019_abnormal_tumor_incidence0.62205984
128MP0005076_abnormal_cell_differentiation0.62078477
129MP0003795_abnormal_bone_structure0.59478185
130MP0005390_skeleton_phenotype0.57650991

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)4.12489898
2Stomatitis (HP:0010280)3.82472664
3Hyperlipoproteinemia (HP:0010980)3.58740885
4Abnormality of T cell number (HP:0011839)3.39983752
5T lymphocytopenia (HP:0005403)3.38165904
6Deep venous thrombosis (HP:0002625)3.36418315
7Pustule (HP:0200039)3.35596648
8Mediastinal lymphadenopathy (HP:0100721)3.24694038
9Chronic otitis media (HP:0000389)3.22335215
10Intrahepatic cholestasis (HP:0001406)3.21728816
11Gingivitis (HP:0000230)3.19290342
12Nasal polyposis (HP:0100582)3.17887041
13Myositis (HP:0100614)3.15348772
14Recurrent bronchitis (HP:0002837)3.08508777
15Xanthomatosis (HP:0000991)3.05225533
16Leukocytosis (HP:0001974)2.97621355
17Increased IgE level (HP:0003212)2.96875714
18Papilledema (HP:0001085)2.94973254
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92720202
20IgM deficiency (HP:0002850)2.92673082
21Abnormality of the nasal mucosa (HP:0000433)2.88995949
22Gingival bleeding (HP:0000225)2.85881153
23Granulocytopenia (HP:0001913)2.85626505
24Chronic obstructive pulmonary disease (HP:0006510)2.84638947
25Obstructive lung disease (HP:0006536)2.84638947
26Recurrent viral infections (HP:0004429)2.82983159
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.81203178
28Recurrent fungal infections (HP:0002841)2.81158411
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71149098
30Arterial thrombosis (HP:0004420)2.68559388
31Abnormality of the fingertips (HP:0001211)2.68320328
32Pulmonary embolism (HP:0002204)2.66676794
33Ketosis (HP:0001946)2.60286456
34Cellulitis (HP:0100658)2.60263358
35Eosinophilia (HP:0001880)2.59277563
36Orchitis (HP:0100796)2.54557817
37Hypoalphalipoproteinemia (HP:0003233)2.51804359
38Slow saccadic eye movements (HP:0000514)2.51784116
39Abnormality of the common coagulation pathway (HP:0010990)2.50998827
40Retrobulbar optic neuritis (HP:0100654)2.50050560
41Optic neuritis (HP:0100653)2.50050560
42Elevated erythrocyte sedimentation rate (HP:0003565)2.49228647
43Complement deficiency (HP:0004431)2.48406880
44Autoimmune hemolytic anemia (HP:0001890)2.46377037
45Autoimmune thrombocytopenia (HP:0001973)2.45706528
46IgG deficiency (HP:0004315)2.43095411
47Abnormality of T cells (HP:0002843)2.42304376
48Eczematoid dermatitis (HP:0000976)2.41636188
49Exercise-induced myalgia (HP:0003738)2.39932989
50Inflammation of the large intestine (HP:0002037)2.38982504
51Gastrointestinal stroma tumor (HP:0100723)2.37724911
52Epistaxis (HP:0000421)2.37614267
53Vasculitis (HP:0002633)2.36952125
54Mitral stenosis (HP:0001718)2.35974015
55Recurrent gram-negative bacterial infections (HP:0005420)2.29635943
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.29255717
57Chronic diarrhea (HP:0002028)2.27889345
58Urticaria (HP:0001025)2.27770142
59Macroorchidism (HP:0000053)2.25708363
60Combined immunodeficiency (HP:0005387)2.25682324
61Aortic aneurysm (HP:0004942)2.25034331
62Spontaneous hematomas (HP:0007420)2.23866277
63Gastrointestinal inflammation (HP:0004386)2.22663352
64Colitis (HP:0002583)2.18817186
65Prolonged bleeding time (HP:0003010)2.17905673
66Osteomyelitis (HP:0002754)2.17731789
67Recurrent skin infections (HP:0001581)2.17042635
68Increased IgM level (HP:0003496)2.15742893
69Ketoacidosis (HP:0001993)2.15174659
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14294029
71Hypoplasia of the thymus (HP:0000778)2.13920187
72Joint hemorrhage (HP:0005261)2.13430498
73Recurrent cutaneous fungal infections (HP:0011370)2.13378998
74Chronic mucocutaneous candidiasis (HP:0002728)2.13378998
75Recurrent bacterial skin infections (HP:0005406)2.12021663
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11914390
77Peritonitis (HP:0002586)2.11730912
78Acute hepatic failure (HP:0006554)2.11363382
79Pulmonary infiltrates (HP:0002113)2.10707916
80Meningitis (HP:0001287)2.08858809
81Impaired platelet aggregation (HP:0003540)2.08682762
82Abnormal platelet function (HP:0011869)2.08682762
83Hypolipoproteinemia (HP:0010981)2.07181026
84Anorexia (HP:0002039)2.05813367
85Panhypogammaglobulinemia (HP:0003139)2.03555634
86Thyroiditis (HP:0100646)2.03437583
87Keratoconjunctivitis sicca (HP:0001097)2.03153435
88Viral hepatitis (HP:0006562)2.02342118
89Hypochromic anemia (HP:0001931)2.00787969
90Subacute progressive viral hepatitis (HP:0006572)2.00432796
91Papilloma (HP:0012740)1.99507989
92Verrucae (HP:0200043)1.99507989
93Gangrene (HP:0100758)1.98211188
94Fatigue (HP:0012378)1.98163581
95Hyperammonemia (HP:0001987)1.96336105
96Periodontitis (HP:0000704)1.96027650
97Hypergammaglobulinemia (HP:0010702)1.95790719
98Hypochromic microcytic anemia (HP:0004840)1.95323866
99Agammaglobulinemia (HP:0004432)1.95133036
100Thrombophlebitis (HP:0004418)1.95059928
101Abnormality of the pleura (HP:0002103)1.93988928
102Myocardial infarction (HP:0001658)1.93612993
103Sepsis (HP:0100806)1.93446522
104B lymphocytopenia (HP:0010976)1.93105687
105Abnormality of B cell number (HP:0010975)1.93105687
106Prolonged partial thromboplastin time (HP:0003645)1.92634739
107Facial diplegia (HP:0001349)1.92556419
108Recurrent abscess formation (HP:0002722)1.91964295
109Abnormality of the peritoneum (HP:0002585)1.91901453
110Encephalitis (HP:0002383)1.91541686
111Abnormality of T cell physiology (HP:0011840)1.90932837
112Recurrent sinusitis (HP:0011108)1.90060909
113Acanthocytosis (HP:0001927)1.89873636
114Abnormality of fatty-acid metabolism (HP:0004359)1.88656153
115Joint swelling (HP:0001386)1.88352983
116Interstitial pulmonary disease (HP:0006530)1.87787455
117Bronchitis (HP:0012387)1.87617461
118Hypertriglyceridemia (HP:0002155)1.85933271
119Abnormality of macrophages (HP:0004311)1.85514124
120Glomerulopathy (HP:0100820)1.84961152
121Hematochezia (HP:0002573)1.83448302
122Hypercholesterolemia (HP:0003124)1.82517511
123Chest pain (HP:0100749)1.82034058
124Tetraparesis (HP:0002273)1.81003935
125Lymphopenia (HP:0001888)1.80679848
126Microcytic anemia (HP:0001935)1.80416030
127Severe combined immunodeficiency (HP:0004430)1.80026065
128Keratoconjunctivitis (HP:0001096)1.79678134
129Abnormal platelet volume (HP:0011876)1.78617537
130Episodic fever (HP:0001954)1.78488762
131Skin ulcer (HP:0200042)1.78405288
132Hemoptysis (HP:0002105)1.78019222
133Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77962178
134Hypobetalipoproteinemia (HP:0003563)1.76250003
135Spondylolisthesis (HP:0003302)1.75416187
136Myoglobinuria (HP:0002913)1.74843470
137Basal cell carcinoma (HP:0002671)1.74427443
138Asymmetric septal hypertrophy (HP:0001670)1.74281190
139Menorrhagia (HP:0000132)1.72986473
140Abnormality of eosinophils (HP:0001879)1.72869645
141Abnormality of the endocardium (HP:0004306)1.72862232
142Neoplasm of the tracheobronchial system (HP:0100552)1.71522257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.61908019
2TXK3.57151048
3PRPF4B2.69737903
4TRIB32.58959857
5FGFR42.51889803
6TYK22.38510040
7TAOK32.34049055
8JAK12.33922511
9JAK32.33780713
10PKN22.25960320
11ITK1.93538959
12FGFR31.84654554
13IKBKE1.81685182
14EPHB11.80306637
15KIT1.78697408
16SIK11.78551501
17MAP3K71.73660577
18ZAP701.64151994
19TBK11.64071465
20STK101.61316268
21MAP3K141.53097348
22MAP3K131.52771853
23ERN11.45713599
24EEF2K1.38614214
25TGFBR21.36163917
26FGFR21.33538865
27CSF1R1.33115759
28TTN1.30806264
29BTK1.27042139
30DMPK1.26595579
31PRKCH1.25370793
32GRK61.24598980
33SGK31.24276612
34PTK61.23523350
35LRRK21.23080086
36FGR1.21522151
37LCK1.21112059
38PRKCQ1.20239825
39NEK91.19230731
40YES11.17213835
41KSR21.16968399
42MAPK121.16182959
43JAK21.15407284
44CAMK1G1.14674123
45CSK1.13689664
46MAP2K31.13001399
47FLT31.12265249
48TNK21.09211117
49SIK31.08717596
50SYK1.08223570
51BMPR21.07475921
52HCK1.03975030
53BCKDK1.03499002
54MAP3K21.03266281
55FES1.03083893
56CAMK1D1.02331555
57CDK121.01626817
58MAP3K11.00808488
59TEC0.99072817
60PDK10.98692963
61MAP3K30.96199029
62RIPK10.95448720
63IRAK30.94133891
64MAPK70.92837065
65FRK0.91802620
66PIK3CG0.86936054
67STK380.85188025
68WNK10.82776313
69RET0.82020329
70TAOK10.80472360
71IKBKB0.79820054
72IRAK40.78504843
73PASK0.78118938
74MAP3K60.77402261
75MAPK110.76356737
76IRAK10.76136763
77EPHA30.76006385
78SGK20.75828395
79PDGFRB0.74669250
80CDK90.73246859
81STK240.72963235
82BLK0.71930361
83CDC42BPA0.71614777
84PIM10.67653395
85PTK2B0.65975083
86BRD40.65939351
87INSRR0.65909036
88PRKAA20.65003337
89CAMKK10.63948568
90HIPK20.63342031
91SIK20.62986714
92PDPK10.62575024
93MARK30.61518254
94DYRK1B0.59413312
95PIK3CA0.56885244
96MAP3K100.56240354
97MAP2K20.54281871
98TNIK0.53634697
99MELK0.52822519
100CAMKK20.52537849
101MAPK40.50881530
102IGF1R0.50182988
103SGK2230.49939314
104SGK4940.49939314
105FYN0.49572655
106LYN0.48348528
107CHUK0.48279800
108TRPM70.47921175
109MARK20.46680721
110PRKD20.45294503
111PRKD10.45263763
112STK110.44925232
113MAPKAPK50.44354652
114MAP2K60.43286311
115RAF10.42482554
116STK390.42105002
117TYRO30.41318357
118NLK0.41317928
119KSR10.40582224
120PHKG10.40024822
121PHKG20.40024822
122MAPK150.37887268
123IRAK20.37591622
124RIPK40.36841249
125FGFR10.36645737
126LMTK20.36023177
127MAP3K110.35227135
128MATK0.34958099
129CAMK40.34556809

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.65043681
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.33334448
3Primary immunodeficiency_Homo sapiens_hsa053402.25842568
4Fatty acid degradation_Homo sapiens_hsa000712.19912437
5Caffeine metabolism_Homo sapiens_hsa002322.11597714
6Graft-versus-host disease_Homo sapiens_hsa053322.01616679
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80868576
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78448765
9Propanoate metabolism_Homo sapiens_hsa006401.69714869
10Staphylococcus aureus infection_Homo sapiens_hsa051501.69474058
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66142510
12Fatty acid metabolism_Homo sapiens_hsa012121.66052024
13T cell receptor signaling pathway_Homo sapiens_hsa046601.64633019
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63690875
15Arginine biosynthesis_Homo sapiens_hsa002201.61975179
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59681703
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.56778217
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53046720
19PPAR signaling pathway_Homo sapiens_hsa033201.50687329
20Complement and coagulation cascades_Homo sapiens_hsa046101.49837149
21B cell receptor signaling pathway_Homo sapiens_hsa046621.47453002
22Tryptophan metabolism_Homo sapiens_hsa003801.43806607
23ABC transporters_Homo sapiens_hsa020101.38808787
24Lysine degradation_Homo sapiens_hsa003101.37105160
25Type I diabetes mellitus_Homo sapiens_hsa049401.32588258
26Osteoclast differentiation_Homo sapiens_hsa043801.30246653
27Influenza A_Homo sapiens_hsa051641.25510078
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24826837
29Herpes simplex infection_Homo sapiens_hsa051681.22159603
30Bile secretion_Homo sapiens_hsa049761.21655378
31Leishmaniasis_Homo sapiens_hsa051401.11824863
32Peroxisome_Homo sapiens_hsa041461.09379806
33Measles_Homo sapiens_hsa051621.09328473
34VEGF signaling pathway_Homo sapiens_hsa043701.09047101
35Butanoate metabolism_Homo sapiens_hsa006501.08168172
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07622095
37Renal cell carcinoma_Homo sapiens_hsa052111.07219952
38Endometrial cancer_Homo sapiens_hsa052131.03053149
39Choline metabolism in cancer_Homo sapiens_hsa052311.02260863
40Fatty acid biosynthesis_Homo sapiens_hsa000611.01908057
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.01762264
42Insulin resistance_Homo sapiens_hsa049311.00462038
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98060019
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.97570313
45mTOR signaling pathway_Homo sapiens_hsa041500.96650719
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.96570376
47Toxoplasmosis_Homo sapiens_hsa051450.93231554
48* FoxO signaling pathway_Homo sapiens_hsa040680.92909381
49Platelet activation_Homo sapiens_hsa046110.88747670
50Colorectal cancer_Homo sapiens_hsa052100.87023870
51Apoptosis_Homo sapiens_hsa042100.86840681
52Allograft rejection_Homo sapiens_hsa053300.84197642
53Legionellosis_Homo sapiens_hsa051340.84040860
54beta-Alanine metabolism_Homo sapiens_hsa004100.83829219
55Chemokine signaling pathway_Homo sapiens_hsa040620.83024423
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.80852010
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78120415
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77391763
59Fatty acid elongation_Homo sapiens_hsa000620.76929988
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76825020
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75696733
62Glycerolipid metabolism_Homo sapiens_hsa005610.75447915
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74967721
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74735369
65Prostate cancer_Homo sapiens_hsa052150.74490569
66Hematopoietic cell lineage_Homo sapiens_hsa046400.73883693
67Pertussis_Homo sapiens_hsa051330.73812173
68Asthma_Homo sapiens_hsa053100.73702853
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72922408
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72720191
71Starch and sucrose metabolism_Homo sapiens_hsa005000.72596457
72GnRH signaling pathway_Homo sapiens_hsa049120.72509135
73Shigellosis_Homo sapiens_hsa051310.70701988
74Pyruvate metabolism_Homo sapiens_hsa006200.70010149
75Acute myeloid leukemia_Homo sapiens_hsa052210.69428580
76ErbB signaling pathway_Homo sapiens_hsa040120.68776240
77Histidine metabolism_Homo sapiens_hsa003400.67643018
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.67419638
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67412516
80HTLV-I infection_Homo sapiens_hsa051660.66709601
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66484334
82Antigen processing and presentation_Homo sapiens_hsa046120.65766285
83Notch signaling pathway_Homo sapiens_hsa043300.65608663
84Autoimmune thyroid disease_Homo sapiens_hsa053200.64970934
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64942352
86Long-term potentiation_Homo sapiens_hsa047200.63125933
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.62963199
88Phagosome_Homo sapiens_hsa041450.61326109
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60227352
90* Viral carcinogenesis_Homo sapiens_hsa052030.59787043
91Glioma_Homo sapiens_hsa052140.59786133
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59770272
93Pancreatic cancer_Homo sapiens_hsa052120.59301272
94African trypanosomiasis_Homo sapiens_hsa051430.58739025
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57930227
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57856356
97TNF signaling pathway_Homo sapiens_hsa046680.56904047
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.56428703
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54496142
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54427166
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54340574
102Viral myocarditis_Homo sapiens_hsa054160.54169609
103Thyroid cancer_Homo sapiens_hsa052160.52841612
104MAPK signaling pathway_Homo sapiens_hsa040100.51968518
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.51813237
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51800763
107Chronic myeloid leukemia_Homo sapiens_hsa052200.51739009
108HIF-1 signaling pathway_Homo sapiens_hsa040660.51122963
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50751085
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50599609
111Epstein-Barr virus infection_Homo sapiens_hsa051690.48841127
112Estrogen signaling pathway_Homo sapiens_hsa049150.48578506
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48038407
114Chemical carcinogenesis_Homo sapiens_hsa052040.47698821
115Amoebiasis_Homo sapiens_hsa051460.47666234
116Retinol metabolism_Homo sapiens_hsa008300.47367019
117Non-small cell lung cancer_Homo sapiens_hsa052230.47299070
118Inositol phosphate metabolism_Homo sapiens_hsa005620.46577335
119Glucagon signaling pathway_Homo sapiens_hsa049220.45842387
120Other glycan degradation_Homo sapiens_hsa005110.45581524
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45489241
122Small cell lung cancer_Homo sapiens_hsa052220.45418736
123Regulation of autophagy_Homo sapiens_hsa041400.44609094
124AMPK signaling pathway_Homo sapiens_hsa041520.43917341
125Prolactin signaling pathway_Homo sapiens_hsa049170.43346947
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.42289556
127Circadian rhythm_Homo sapiens_hsa047100.42028702
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41946782
129Hepatitis C_Homo sapiens_hsa051600.41680982
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41404267
131Ras signaling pathway_Homo sapiens_hsa040140.41270643
132Salmonella infection_Homo sapiens_hsa051320.40633977
133Malaria_Homo sapiens_hsa051440.39886005
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.39538708
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39307694
136Tuberculosis_Homo sapiens_hsa051520.39129123
137Endocytosis_Homo sapiens_hsa041440.38888785
138Type II diabetes mellitus_Homo sapiens_hsa049300.38570014
139Insulin signaling pathway_Homo sapiens_hsa049100.38135129
140Hepatitis B_Homo sapiens_hsa051610.38095263
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38021413
142Renin secretion_Homo sapiens_hsa049240.37369280
143Carbon metabolism_Homo sapiens_hsa012000.36886134
144Dorso-ventral axis formation_Homo sapiens_hsa043200.35777234
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35125570

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