RBM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.51120863
2DNA strand elongation involved in DNA replication (GO:0006271)5.00149466
3protein localization to kinetochore (GO:0034501)4.93705986
4DNA strand elongation (GO:0022616)4.80810923
5DNA replication initiation (GO:0006270)4.57968932
6telomere maintenance via semi-conservative replication (GO:0032201)4.57779008
7ribosomal small subunit assembly (GO:0000028)4.16118027
8protein localization to chromosome, centromeric region (GO:0071459)4.13647378
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.13396848
10DNA replication checkpoint (GO:0000076)4.11380520
11nucleobase biosynthetic process (GO:0046112)4.10672338
12folic acid-containing compound biosynthetic process (GO:0009396)4.10598691
13mitotic nuclear envelope disassembly (GO:0007077)4.02801757
14telomere maintenance via recombination (GO:0000722)3.99223997
15DNA replication-dependent nucleosome organization (GO:0034723)3.97102109
16DNA replication-dependent nucleosome assembly (GO:0006335)3.97102109
17mitotic chromosome condensation (GO:0007076)3.93282835
18IMP biosynthetic process (GO:0006188)3.91078564
19mitotic recombination (GO:0006312)3.89414464
20negative regulation of erythrocyte differentiation (GO:0045647)3.87449842
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81238851
22intracellular estrogen receptor signaling pathway (GO:0030520)3.78792263
23negative regulation of RNA splicing (GO:0033119)3.78701726
24nuclear pore organization (GO:0006999)3.76643107
25telomere maintenance via telomere lengthening (GO:0010833)3.72319546
26nuclear envelope disassembly (GO:0051081)3.71725251
27membrane disassembly (GO:0030397)3.71725251
28maturation of SSU-rRNA (GO:0030490)3.71222169
29DNA duplex unwinding (GO:0032508)3.69016574
30regulation of NFAT protein import into nucleus (GO:0051532)3.68073652
31DNA geometric change (GO:0032392)3.66302005
32translesion synthesis (GO:0019985)3.65858385
33mitotic metaphase plate congression (GO:0007080)3.65502732
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.65092780
35formation of translation preinitiation complex (GO:0001731)3.64189547
36peptidyl-arginine N-methylation (GO:0035246)3.63735503
37peptidyl-arginine methylation (GO:0018216)3.63735503
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60868779
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.60868779
40nuclear pore complex assembly (GO:0051292)3.58856603
41proline biosynthetic process (GO:0006561)3.58552539
42COPI coating of Golgi vesicle (GO:0048205)3.57932500
43Golgi transport vesicle coating (GO:0048200)3.57932500
44regulation of chromatin binding (GO:0035561)3.56908140
45regulation of RNA export from nucleus (GO:0046831)3.56692711
46dosage compensation (GO:0007549)3.54926539
47mitotic sister chromatid segregation (GO:0000070)3.53159156
48negative regulation of mRNA processing (GO:0050686)3.51833146
49sister chromatid segregation (GO:0000819)3.51697320
50purine nucleobase biosynthetic process (GO:0009113)3.51645315
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44608539
52protein retention in ER lumen (GO:0006621)3.42248201
53regulation of nucleobase-containing compound transport (GO:0032239)3.39070045
54ribosome biogenesis (GO:0042254)3.38829308
55mitotic sister chromatid cohesion (GO:0007064)3.36124201
56viral transcription (GO:0019083)3.33927029
57pre-miRNA processing (GO:0031054)3.32787101
58metaphase plate congression (GO:0051310)3.31463687
59histone arginine methylation (GO:0034969)3.30665934
60DNA replication-independent nucleosome organization (GO:0034724)3.29418592
61DNA replication-independent nucleosome assembly (GO:0006336)3.29418592
62negative regulation of cell size (GO:0045792)3.28332494
63apoptotic process involved in morphogenesis (GO:0060561)3.28194966
64translational termination (GO:0006415)3.26958726
65regulation of spindle organization (GO:0090224)3.26507412
66mRNA splicing, via spliceosome (GO:0000398)3.26447175
67RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.26447175
68postreplication repair (GO:0006301)3.26107897
69RNA splicing, via transesterification reactions (GO:0000375)3.24387056
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20962729
71negative regulation of histone methylation (GO:0031061)3.20501486
72IMP metabolic process (GO:0046040)3.19439258
73kinetochore organization (GO:0051383)3.18972555
74pentose-phosphate shunt (GO:0006098)3.18698654
75CENP-A containing nucleosome assembly (GO:0034080)3.18259652
76chromatin remodeling at centromere (GO:0031055)3.17072393
77chromatin assembly or disassembly (GO:0006333)3.16698471
78translational elongation (GO:0006414)3.15508923
79negative regulation of mRNA metabolic process (GO:1903312)3.15494876
80chromosome condensation (GO:0030261)3.12849205
81ATP-dependent chromatin remodeling (GO:0043044)3.12466616
82retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11825559
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10817502
84protein localization to chromosome (GO:0034502)3.10345737
85DNA deamination (GO:0045006)3.10022916
86termination of RNA polymerase II transcription (GO:0006369)3.09625384
87nuclear envelope reassembly (GO:0031468)3.08874398
88mitotic nuclear envelope reassembly (GO:0007084)3.08874398
89spliceosomal snRNP assembly (GO:0000387)3.08757431
90spliceosomal tri-snRNP complex assembly (GO:0000244)3.08637878
91intra-S DNA damage checkpoint (GO:0031573)3.08225358
92peptidyl-arginine omega-N-methylation (GO:0035247)3.08007948
93translational initiation (GO:0006413)3.07522126
94regulation of helicase activity (GO:0051095)3.07383656
95DNA topological change (GO:0006265)3.07165500
96ribonucleoprotein complex biogenesis (GO:0022613)3.06575030
97DNA conformation change (GO:0071103)3.06026555
98activation of Rac GTPase activity (GO:0032863)3.04611276
99regulation of sister chromatid cohesion (GO:0007063)3.04049787
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03430437
101planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01767752
102RNA export from nucleus (GO:0006405)3.01097491
103negative regulation of DNA-templated transcription, elongation (GO:0032785)3.00911684
104regulation of translational fidelity (GO:0006450)3.00537219
105snRNA metabolic process (GO:0016073)3.00147433
106establishment of chromosome localization (GO:0051303)2.98947892
107positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.96996512
108mismatch repair (GO:0006298)2.96968624
109mRNA export from nucleus (GO:0006406)2.95649175
110histone H4 deacetylation (GO:0070933)2.95646339
111telomere maintenance (GO:0000723)2.94714514
112protein export from nucleus (GO:0006611)2.93757352
113attachment of spindle microtubules to kinetochore (GO:0008608)2.93118009
114heterochromatin organization (GO:0070828)2.93027214
115telomere organization (GO:0032200)2.92729381
116nuclear envelope organization (GO:0006998)2.91930360
117spliceosomal complex assembly (GO:0000245)2.91542421
118activation of MAPKKK activity (GO:0000185)2.90627737
119protein-DNA complex disassembly (GO:0032986)2.90037384
120nucleosome disassembly (GO:0006337)2.90037384
121positive regulation of chromosome segregation (GO:0051984)2.89724687
122regulation of histone H3-K9 methylation (GO:0051570)2.89383990
123negative regulation of chromosome segregation (GO:0051985)2.88319236
124chromatin assembly (GO:0031497)2.87556548
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.87187602
126protein maturation by protein folding (GO:0022417)2.86742954
127poly(A)+ mRNA export from nucleus (GO:0016973)2.86386899
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86312725
129establishment of integrated proviral latency (GO:0075713)2.86129135
130regulation of chromosome segregation (GO:0051983)2.85958405
131ribosomal small subunit biogenesis (GO:0042274)2.85383654
132mRNA transport (GO:0051028)2.84727097
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84641678
134negative regulation of sister chromatid segregation (GO:0033046)2.84641678
135glucose 6-phosphate metabolic process (GO:0051156)2.84042947
136maternal placenta development (GO:0001893)2.82550211
137* mRNA stabilization (GO:0048255)2.82417293
138* RNA stabilization (GO:0043489)2.82417293
139glucose catabolic process (GO:0006007)2.76840308
1403-UTR-mediated mRNA stabilization (GO:0070935)2.76367911
141NADPH regeneration (GO:0006740)2.70303006
142negative regulation of microtubule polymerization (GO:0031115)2.68867155
143protein complex disassembly (GO:0043241)2.64064003
144stress granule assembly (GO:0034063)2.63265842
145snRNA processing (GO:0016180)2.61703206
146viral mRNA export from host cell nucleus (GO:0046784)2.61332743
147cell-cell junction maintenance (GO:0045217)2.59600585
148pore complex assembly (GO:0046931)2.56615857
149adherens junction assembly (GO:0034333)2.53250484
150rRNA transcription (GO:0009303)2.53194951
151protein complex localization (GO:0031503)2.52785351
152L-serine metabolic process (GO:0006563)2.52783843
153viral life cycle (GO:0019058)2.51089153
154DNA packaging (GO:0006323)2.47411262
155modulation by virus of host process (GO:0019054)2.45368876
156RNA localization (GO:0006403)2.42522947
157macromolecular complex disassembly (GO:0032984)2.42488263
158positive regulation of receptor biosynthetic process (GO:0010870)2.41288966
159convergent extension (GO:0060026)2.39712506
160regulation of mitotic spindle organization (GO:0060236)2.39505117
161histone H3 deacetylation (GO:0070932)2.39377648
162cellular response to epidermal growth factor stimulus (GO:0071364)2.38776207
163cellular hyperosmotic response (GO:0071474)2.38737573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.36688215
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32036792
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.87338017
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71575411
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68053919
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15445254
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82135352
8MYC_22102868_ChIP-Seq_BL_Human2.69630112
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59378138
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.52540820
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47730360
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47684090
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.38809563
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.34703681
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32727704
16* XRN2_22483619_ChIP-Seq_HELA_Human2.31203850
17LXR_22292898_ChIP-Seq_THP-1_Human2.28104837
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26213321
19CIITA_25753668_ChIP-Seq_RAJI_Human2.22036598
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17608118
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.15814864
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14020655
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12186102
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.06908169
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.05169709
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94834023
27FOXP3_21729870_ChIP-Seq_TREG_Human1.89872833
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89576220
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88296324
30VDR_23849224_ChIP-Seq_CD4+_Human1.87335380
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87126133
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86577468
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83882890
34KDM2B_26808549_Chip-Seq_DND41_Human1.83590120
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.82347612
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81469888
37AR_21909140_ChIP-Seq_LNCAP_Human1.79822507
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.79011453
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78844190
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73697391
41GABP_19822575_ChIP-Seq_HepG2_Human1.73296628
42RACK7_27058665_Chip-Seq_MCF-7_Human1.70418170
43TTF2_22483619_ChIP-Seq_HELA_Human1.68308800
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68002883
45VDR_21846776_ChIP-Seq_THP-1_Human1.67589352
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66910900
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66053490
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64892487
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64759379
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63995040
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63768106
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63514863
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63443766
54DCP1A_22483619_ChIP-Seq_HELA_Human1.62049976
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61954461
56KDM5A_27292631_Chip-Seq_BREAST_Human1.58917579
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.58828994
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57835835
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52547889
60P68_20966046_ChIP-Seq_HELA_Human1.50877304
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45007493
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44183789
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43060362
64KDM2B_26808549_Chip-Seq_K562_Human1.43058463
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41489307
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.39393936
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38800594
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37095725
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.34742175
70ZNF263_19887448_ChIP-Seq_K562_Human1.33991784
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33775541
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.33082025
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31318588
74MAF_26560356_Chip-Seq_TH2_Human1.30250728
75NCOR1_26117541_ChIP-Seq_K562_Human1.30076515
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29591335
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29543022
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28925701
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28742036
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28363193
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28011407
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27722376
83SMC4_20622854_ChIP-Seq_HELA_Human1.26935640
84CREB1_26743006_Chip-Seq_LNCaP_Human1.26393227
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26050414
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24490158
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24476913
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24394072
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23993845
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23084345
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.22992856
92TFEB_21752829_ChIP-Seq_HELA_Human1.22462585
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.22004991
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21344145
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19273490
96ELK1_19687146_ChIP-ChIP_HELA_Human1.17711414
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17576275
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16219279
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15595295
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13978971
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13344155
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12893381
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12459551
104VDR_24763502_ChIP-Seq_THP-1_Human1.11937141
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10283803
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09697076
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09398253
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06836785
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05878454
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05568211
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05427285
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04581084
113UTX_26944678_Chip-Seq_JUKART_Human1.04480003
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04422148
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04321933
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02483655
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01983317
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01972724
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01856233
120TP53_22127205_ChIP-Seq_IMR90_Human1.01531618
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01477071
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01246226
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00943182
124TCF7_22412390_ChIP-Seq_EML_Mouse1.00864485
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00780771
126RUNX1_22412390_ChIP-Seq_EML_Mouse1.00020916
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98897686
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98720329
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.97968980
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97898836
131ATF3_27146783_Chip-Seq_COLON_Human0.97782531
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97735701
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96650096
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96549585
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.94369383
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93700566
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90506741
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.90004841
139MYC_18940864_ChIP-ChIP_HL60_Human0.89548943
140MAF_26560356_Chip-Seq_TH1_Human0.87564853
141SPI1_23547873_ChIP-Seq_NB4_Human0.87301207
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84925832
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84908731
144CHD1_26751641_Chip-Seq_LNCaP_Human0.83603583
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.82936885
146MYB_26560356_Chip-Seq_TH1_Human0.81507022
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81095041
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78521039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.00688770
2MP0010094_abnormal_chromosome_stability4.64261171
3MP0003111_abnormal_nucleus_morphology4.27734509
4MP0004957_abnormal_blastocyst_morpholog3.83862487
5MP0003077_abnormal_cell_cycle3.80111981
6MP0008057_abnormal_DNA_replication3.49627283
7MP0008058_abnormal_DNA_repair3.31187564
8MP0003123_paternal_imprinting3.07754305
9MP0005451_abnormal_body_composition2.85937785
10MP0008007_abnormal_cellular_replicative2.80662223
11MP0002396_abnormal_hematopoietic_system2.77158600
12MP0008260_abnormal_autophagy2.62089325
13MP0001730_embryonic_growth_arrest2.53014894
14MP0003121_genomic_imprinting2.44990913
15MP0004185_abnormal_adipocyte_glucose2.37805953
16MP0004858_abnormal_nervous_system2.36554158
17MP0000350_abnormal_cell_proliferation2.27537271
18MP0010352_gastrointestinal_tract_polyps2.26432675
19MP0008932_abnormal_embryonic_tissue2.14796959
20MP0008877_abnormal_DNA_methylation1.93141130
21MP0010307_abnormal_tumor_latency1.92864426
22MP0005380_embryogenesis_phenotype1.91496424
23MP0001672_abnormal_embryogenesis/_devel1.91496424
24MP0002249_abnormal_larynx_morphology1.91237858
25MP0001348_abnormal_lacrimal_gland1.88868258
26MP0004233_abnormal_muscle_weight1.85922960
27MP0001697_abnormal_embryo_size1.84149758
28MP0010030_abnormal_orbit_morphology1.77159760
29MP0004808_abnormal_hematopoietic_stem1.75575301
30MP0003984_embryonic_growth_retardation1.75235849
31MP0002085_abnormal_embryonic_tissue1.75068605
32MP0000490_abnormal_crypts_of1.74372381
33MP0002080_prenatal_lethality1.72967783
34MP0002088_abnormal_embryonic_growth/wei1.72106381
35MP0005058_abnormal_lysosome_morphology1.70347996
36MP0002084_abnormal_developmental_patter1.69874789
37MP0005076_abnormal_cell_differentiation1.64088696
38MP0004197_abnormal_fetal_growth/weight/1.63968640
39MP0003890_abnormal_embryonic-extraembry1.56996642
40MP0003787_abnormal_imprinting1.56388208
41MP0006292_abnormal_olfactory_placode1.54804018
42MP0003763_abnormal_thymus_physiology1.53762500
43MP0002086_abnormal_extraembryonic_tissu1.52008230
44MP0000703_abnormal_thymus_morphology1.49714966
45MP0000313_abnormal_cell_death1.48641337
46MP0002019_abnormal_tumor_incidence1.44046939
47MP0003122_maternal_imprinting1.42452035
48MP0003303_peritoneal_inflammation1.40314458
49MP0005501_abnormal_skin_physiology1.38832111
50MP0003119_abnormal_digestive_system1.36708267
51MP0000537_abnormal_urethra_morphology1.35957054
52MP0005666_abnormal_adipose_tissue1.32362668
53MP0001293_anophthalmia1.32184596
54MP0006054_spinal_hemorrhage1.30688455
55MP0002398_abnormal_bone_marrow1.30165447
56MP0003566_abnormal_cell_adhesion1.27273571
57MP0003436_decreased_susceptibility_to1.26244839
58MP0003786_premature_aging1.25663378
59MP0003453_abnormal_keratinocyte_physiol1.21681015
60MP0009333_abnormal_splenocyte_physiolog1.20362758
61MP0000678_abnormal_parathyroid_gland1.18595714
62MP0000566_synostosis1.15793400
63MP0002653_abnormal_ependyma_morphology1.15502969
64MP0002722_abnormal_immune_system1.15456082
65MP0003315_abnormal_perineum_morphology1.14965251
66MP0009053_abnormal_anal_canal1.12733284
67MP0009672_abnormal_birth_weight1.11445408
68MP0003567_abnormal_fetal_cardiomyocyte1.11110480
69MP0003385_abnormal_body_wall1.10861056
70MP0003172_abnormal_lysosome_physiology1.09766475
71MP0004264_abnormal_extraembryonic_tissu1.07690582
72MP0005623_abnormal_meninges_morphology1.05962686
73MP0000689_abnormal_spleen_morphology1.05465369
74MP0001915_intracranial_hemorrhage1.03499368
75MP0005397_hematopoietic_system_phenotyp0.99885762
76MP0001545_abnormal_hematopoietic_system0.99885762
77MP0001849_ear_inflammation0.99748549
78MP0001346_abnormal_lacrimal_gland0.99662736
79MP0004859_abnormal_synaptic_plasticity0.99164223
80MP0004133_heterotaxia0.98746903
81MP0009703_decreased_birth_body0.96863708
82MP0002089_abnormal_postnatal_growth/wei0.96154643
83MP0005375_adipose_tissue_phenotype0.95806426
84MP0008789_abnormal_olfactory_epithelium0.92564175
85MP0002429_abnormal_blood_cell0.91996908
86MP0005409_darkened_coat_color0.91628923
87MP0002111_abnormal_tail_morphology0.91310339
88MP0001727_abnormal_embryo_implantation0.90229326
89MP0010630_abnormal_cardiac_muscle0.90092627
90MP0000003_abnormal_adipose_tissue0.87486669
91MP0009278_abnormal_bone_marrow0.85834982
92MP0009840_abnormal_foam_cell0.85442053
93MP0002938_white_spotting0.85242019
94MP0000428_abnormal_craniofacial_morphol0.85223814
95MP0000733_abnormal_muscle_development0.85081521
96MP0003935_abnormal_craniofacial_develop0.84623305
97MP0005394_taste/olfaction_phenotype0.83998889
98MP0005499_abnormal_olfactory_system0.83998889
99MP0000750_abnormal_muscle_regeneration0.82620017
100MP0000747_muscle_weakness0.82321133
101MP0003300_gastrointestinal_ulcer0.81711218
102MP0005384_cellular_phenotype0.81545307
103MP0000477_abnormal_intestine_morphology0.80658883
104MP0003329_amyloid_beta_deposits0.80264854
105MP0003221_abnormal_cardiomyocyte_apopto0.79638905
106MP0002092_abnormal_eye_morphology0.79122915
107MP0003091_abnormal_cell_migration0.78486125
108MP0002877_abnormal_melanocyte_morpholog0.77876641
109MP0002210_abnormal_sex_determination0.77795994
110MP0000716_abnormal_immune_system0.77482880
111MP0000681_abnormal_thyroid_gland0.75073588
112MP0002132_abnormal_respiratory_system0.73522949
113MP0005621_abnormal_cell_physiology0.73357711
114MP0008770_decreased_survivor_rate0.72892910
115MP0002970_abnormal_white_adipose0.72845150
116MP0003115_abnormal_respiratory_system0.72182274
117MP0000759_abnormal_skeletal_muscle0.72055798
118MP0001145_abnormal_male_reproductive0.71971030
119MP0006035_abnormal_mitochondrial_morpho0.71677923
120MP0009379_abnormal_foot_pigmentation0.71484370
121MP0001286_abnormal_eye_development0.71480334
122MP0002796_impaired_skin_barrier0.71456562
123MP0009931_abnormal_skin_appearance0.71402946
124MP0005220_abnormal_exocrine_pancreas0.71325060
125MP0002925_abnormal_cardiovascular_devel0.70495510
126MP0003861_abnormal_nervous_system0.69831273
127MP0000465_gastrointestinal_hemorrhage0.69559381
128MP0000858_altered_metastatic_potential0.68126338
129MP0003283_abnormal_digestive_organ0.68056870
130MP0002697_abnormal_eye_size0.66099113
131MP0003942_abnormal_urinary_system0.65336459
132MP0000358_abnormal_cell_content/0.64931059
133MP0003705_abnormal_hypodermis_morpholog0.62549853
134MP0002932_abnormal_joint_morphology0.62252043
135MP0003937_abnormal_limbs/digits/tail_de0.62163916
136MP0001800_abnormal_humoral_immune0.61175027
137MP0003866_abnormal_defecation0.60584726
138MP0008995_early_reproductive_senescence0.59434386
139MP0008961_abnormal_basal_metabolism0.59329660
140MP0002114_abnormal_axial_skeleton0.59161458
141MP0000266_abnormal_heart_morphology0.57007856
142MP0000653_abnormal_sex_gland0.56951590

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.60443526
2Medulloblastoma (HP:0002885)3.86349900
3Colon cancer (HP:0003003)3.58192436
4Reticulocytopenia (HP:0001896)3.54239374
5Birth length less than 3rd percentile (HP:0003561)3.43710328
6Aplastic anemia (HP:0001915)3.21689497
7Long palpebral fissure (HP:0000637)3.14864810
8Proximal placement of thumb (HP:0009623)3.12716080
9Astrocytoma (HP:0009592)3.10573292
10Abnormality of the astrocytes (HP:0100707)3.10573292
11Patellar aplasia (HP:0006443)3.05000506
12Rhabdomyosarcoma (HP:0002859)2.99518826
13Chromsome breakage (HP:0040012)2.98128020
14Degeneration of anterior horn cells (HP:0002398)2.97932296
15Abnormality of the anterior horn cell (HP:0006802)2.97932296
16Deviation of the thumb (HP:0009603)2.97551921
17Broad distal phalanx of finger (HP:0009836)2.97142919
18Selective tooth agenesis (HP:0001592)2.95260548
19Basal cell carcinoma (HP:0002671)2.93900091
20Increased nuchal translucency (HP:0010880)2.92393688
2111 pairs of ribs (HP:0000878)2.91575571
22Abnormal number of incisors (HP:0011064)2.90471258
23Aplasia/Hypoplasia of the patella (HP:0006498)2.80658926
24Oral leukoplakia (HP:0002745)2.75854927
25Ulnar bowing (HP:0003031)2.74152044
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73279564
27Short 4th metacarpal (HP:0010044)2.73279564
28Neoplasm of striated muscle (HP:0009728)2.70152817
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69682865
30Achilles tendon contracture (HP:0001771)2.69447674
31Pointed chin (HP:0000307)2.68003234
32Glioma (HP:0009733)2.67663397
33Myelodysplasia (HP:0002863)2.66016032
34Renal duplication (HP:0000075)2.63804218
35Hyperacusis (HP:0010780)2.63553032
36Abnormality of reticulocytes (HP:0004312)2.62977699
37Cortical dysplasia (HP:0002539)2.61577648
38Truncus arteriosus (HP:0001660)2.58889315
39Abnormality of chromosome stability (HP:0003220)2.58820645
40Reticulocytosis (HP:0001923)2.57238113
41Cellulitis (HP:0100658)2.56664454
42Neoplasm of the oral cavity (HP:0100649)2.54981166
43Abnormality of cells of the erythroid lineage (HP:0012130)2.54545288
44Volvulus (HP:0002580)2.54493739
45Missing ribs (HP:0000921)2.52417401
46Broad face (HP:0000283)2.51623633
47Amaurosis fugax (HP:0100576)2.51515084
48Abnormal number of erythroid precursors (HP:0012131)2.50615268
49* Deep palmar crease (HP:0006191)2.50295661
50Meckel diverticulum (HP:0002245)2.50094113
51Agnosia (HP:0010524)2.49814952
52Neoplasm of the pancreas (HP:0002894)2.47821694
53Cholecystitis (HP:0001082)2.47049886
54Abnormal gallbladder physiology (HP:0012438)2.47049886
55Abnormality of the ileum (HP:0001549)2.40071128
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.39646663
57Patellar dislocation (HP:0002999)2.37701489
58Hyperthyroidism (HP:0000836)2.37561270
59Upper limb amyotrophy (HP:0009129)2.36320887
60Distal upper limb amyotrophy (HP:0007149)2.36320887
61Metaphyseal cupping (HP:0003021)2.35992510
62Breast hypoplasia (HP:0003187)2.35813303
63Overriding aorta (HP:0002623)2.34975001
64Distal lower limb amyotrophy (HP:0008944)2.34158095
65Long eyelashes (HP:0000527)2.32427316
66Obstructive sleep apnea (HP:0002870)2.30769994
67Thrombocytosis (HP:0001894)2.30332368
68Prominent nose (HP:0000448)2.30142694
69Cerebral hypomyelination (HP:0006808)2.29083990
70Trismus (HP:0000211)2.28354914
71Cafe-au-lait spot (HP:0000957)2.28162288
72Abnormality of the aortic arch (HP:0012303)2.27001819
73Abnormality of the preputium (HP:0100587)2.26357902
74Abnormality of the Achilles tendon (HP:0005109)2.25621020
75Elfin facies (HP:0004428)2.24624899
76Atresia of the external auditory canal (HP:0000413)2.17454162
77Disproportionate tall stature (HP:0001519)2.16922833
78Microvesicular hepatic steatosis (HP:0001414)2.16397847
79Abnormality of the fingertips (HP:0001211)2.15593348
80Ragged-red muscle fibers (HP:0003200)2.14348545
81Premature graying of hair (HP:0002216)2.14226395
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.13901609
83IgM deficiency (HP:0002850)2.12936168
84Ectopic kidney (HP:0000086)2.12279382
85High pitched voice (HP:0001620)2.11576668
86Trigonocephaly (HP:0000243)2.09439594
87Small intestinal stenosis (HP:0012848)2.09247754
88Duodenal stenosis (HP:0100867)2.09247754
89Abnormality of the thoracic spine (HP:0100711)2.07804762
90Abnormality of the carotid arteries (HP:0005344)2.07758874
91Cellular immunodeficiency (HP:0005374)2.07714991
92Acute lymphatic leukemia (HP:0006721)2.06814333
93Slender long bone (HP:0003100)2.04339521
94Centrally nucleated skeletal muscle fibers (HP:0003687)2.02420726
95Abnormal lung lobation (HP:0002101)2.01044164
96Hand muscle atrophy (HP:0009130)2.00366959
97Absent thumb (HP:0009777)1.99943469
98Bone marrow hypocellularity (HP:0005528)1.99904197
99Optic nerve coloboma (HP:0000588)1.99162976
100Broad palm (HP:0001169)1.98667338
101Hypoplasia of the pons (HP:0012110)1.97698305
102Skin tags (HP:0010609)1.97121074
103Tracheoesophageal fistula (HP:0002575)1.94952240
104Spina bifida occulta (HP:0003298)1.94668806
105Peripheral hypomyelination (HP:0007182)1.94591757
106Abnormality of the labia minora (HP:0012880)1.94121513
107Supernumerary spleens (HP:0009799)1.93842592
108Atelectasis (HP:0100750)1.93395029
109Multiple enchondromatosis (HP:0005701)1.91855167
110Flattened epiphyses (HP:0003071)1.91185819
111Preauricular skin tag (HP:0000384)1.90711455
112Thoracic kyphosis (HP:0002942)1.90519727
113Cutis marmorata (HP:0000965)1.90154471
114Facial hemangioma (HP:0000329)1.89607886
115Lymphoma (HP:0002665)1.89186094
116Rough bone trabeculation (HP:0100670)1.88585837
117Insomnia (HP:0100785)1.88426544
118High anterior hairline (HP:0009890)1.88103984
119Abnormality of the 4th metacarpal (HP:0010012)1.87742027
120Increased connective tissue (HP:0009025)1.87133776
121Vertebral arch anomaly (HP:0008438)1.86055555
122Precocious puberty (HP:0000826)1.85795613
123Abnormality of the duodenum (HP:0002246)1.84942980
124Angiofibromas (HP:0010615)1.84803963
125Adenoma sebaceum (HP:0009720)1.84803963
126Absent radius (HP:0003974)1.84139822
127Pallor (HP:0000980)1.84071249
128Abnormality of the calcaneus (HP:0008364)1.84021833
129Myopathic facies (HP:0002058)1.83455933
130Progressive external ophthalmoplegia (HP:0000590)1.83153971
131Hypertensive crisis (HP:0100735)1.83099774
132Sloping forehead (HP:0000340)1.83011958
133Bowel incontinence (HP:0002607)1.82958370
134Thin ribs (HP:0000883)1.82436155
135Renovascular hypertension (HP:0100817)1.82368238
136Prominent metopic ridge (HP:0005487)1.80827943
137Overlapping toe (HP:0001845)1.80347062
138Spinal muscular atrophy (HP:0007269)1.78230657
139Abnormal large intestine physiology (HP:0012700)1.77783175
140Macrocytic anemia (HP:0001972)1.77590884
141Seborrheic dermatitis (HP:0001051)1.77276023
142Colitis (HP:0002583)1.76066775
143Lower limb amyotrophy (HP:0007210)1.75290172
144Flared metaphyses (HP:0003015)1.73548590
145Deep philtrum (HP:0002002)1.73406196
146Self-mutilation (HP:0000742)1.73014969
147Anal stenosis (HP:0002025)1.72990262
148Abnormality of the phalanges of the hallux (HP:0010057)1.72893670
149Progressive muscle weakness (HP:0003323)1.72730467
150Biconcave vertebral bodies (HP:0004586)1.72584924
151Mitral regurgitation (HP:0001653)1.72481036
152Difficulty climbing stairs (HP:0003551)1.72472057
153Gastrointestinal carcinoma (HP:0002672)1.72290368
154Malignant gastrointestinal tract tumors (HP:0006749)1.72290368
155Abnormality of the pons (HP:0007361)1.71917227
156Microretrognathia (HP:0000308)1.71855704
157Hyperparathyroidism (HP:0000843)1.70721498
158Segmental peripheral demyelination/remyelination (HP:0003481)1.67221169
159Hypoparathyroidism (HP:0000829)1.65638097
160Annular pancreas (HP:0001734)1.64235227
161Hypercalcemia (HP:0003072)1.64217771
162Generalized hypotonia (HP:0001290)1.63961721
163Pseudobulbar signs (HP:0002200)1.62649099
164Abnormality of the tricuspid valve (HP:0001702)1.61963713
165Premature skin wrinkling (HP:0100678)1.59941785
166Flat acetabular roof (HP:0003180)1.59687887
167Turricephaly (HP:0000262)1.59512293
168Aplasia/Hypoplasia of the sacrum (HP:0008517)1.59464280
169Shallow orbits (HP:0000586)1.59410095
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58091719
171Hypercortisolism (HP:0001578)1.56939705
172Short nail (HP:0001799)1.55853721
173Squamous cell carcinoma (HP:0002860)1.55533503
174Arnold-Chiari malformation (HP:0002308)1.54868563
175Syringomyelia (HP:0003396)1.54150411
176Spinal cord lesions (HP:0100561)1.54150411
177Flat cornea (HP:0007720)1.53865650
178Obsessive-compulsive behavior (HP:0000722)1.52852616
179Heterotopia (HP:0002282)1.51245029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.75161762
2CDC74.40407097
3SMG14.14202299
4BUB13.17813060
5ICK2.99890369
6WEE12.97171331
7PRPF4B2.96839104
8MAP3K102.96457505
9NEK22.75620557
10PASK2.66024585
11SRPK12.52488858
12CDK122.42959039
13RPS6KB22.30732862
14ACVR1B2.25893682
15TSSK62.24469803
16IRAK32.20674995
17EIF2AK12.15573924
18SIK12.13955952
19TLK11.95152581
20TTK1.78827012
21ATR1.76440951
22NEK11.75758550
23PKN21.74909145
24TESK21.74424968
25CDK71.74261419
26IRAK41.73531202
27MAP4K11.69401886
28SIK21.69342944
29BRSK21.68991130
30CDK41.64640994
31PLK11.62796244
32AURKB1.56043418
33MAPKAPK31.55367324
34FGFR41.52376877
35TGFBR11.43878827
36VRK11.40988482
37BRSK11.39851033
38CHEK11.38575856
39DYRK31.38420264
40MAP3K111.35939482
41SCYL21.30765905
42CHEK21.29647372
43STK101.28900821
44BRD41.28664898
45RPS6KA41.27237806
46BRAF1.26084228
47MKNK11.25989426
48TAOK21.25232768
49FLT31.23041243
50PAK41.19509016
51CCNB11.19393220
52STK41.19204215
53PLK31.15515492
54MAP3K81.08782093
55TRIB31.08547857
56CAMK1D1.03638078
57CDK21.00285911
58STK160.96590956
59AURKA0.95390595
60PLK40.95313441
61TYRO30.94884282
62ATM0.91862589
63ALK0.91542529
64TTN0.91313760
65EPHB10.88632070
66KSR20.88208884
67PRKD30.88083782
68PIM10.86183135
69RIPK10.84938480
70MTOR0.84142508
71ERN10.80081680
72IRAK20.77958896
73GRK60.77587960
74MKNK20.77422364
75TESK10.76165020
76PRKD20.76133780
77CLK10.75125031
78CDK90.74391646
79EPHA20.73989312
80MAP2K20.73966666
81PIM20.72520171
82BTK0.72363692
83LRRK20.72101470
84EIF2AK30.70723031
85CDK60.69824963
86CDK10.69170992
87JAK30.68676753
88ARAF0.66876994
89CDK11A0.65320767
90VRK20.64500569
91CAMK1G0.64289337
92MELK0.63591159
93PTK20.62777518
94MAPK110.62099673
95TAF10.61744486
96BMX0.61224699
97NTRK10.59398104
98NME20.58212939
99PDGFRA0.58154156
100PAK10.58069002
101* CSNK2A20.57601419
102CAMKK10.57305428
103CDK150.56329429
104TNK20.55929805
105AKT20.55928987
106DYRK1B0.55844781
107ZAP700.53434150
108PTK60.53293365
109RIPK40.52471148
110ILK0.51850911
111MAP3K10.51365605
112DAPK10.50212037
113CDK180.47977697
114HIPK20.47561528
115CDK80.47295108
116PRKDC0.47058139
117CDK140.45828446
118STK30.45714898
119CDC42BPA0.42864516
120PAK20.42678061
121MAP2K30.41424498
122MAPK140.41390995
123PRKCI0.41202755
124CSNK1E0.40966568
125RPS6KA60.40224416
126RPS6KL10.40134249
127RPS6KC10.40134249
128CSNK2A10.38966545
129PDPK10.38597867
130RET0.35980332
131RPS6KB10.35973417
132RPS6KA20.34519025
133UHMK10.34364502
134SIK30.34314046
135RAF10.34083063
136CDK190.32362647
137TAOK10.31638978
138RPS6KA10.31113531
139CHUK0.30374326
140ZAK0.29948486
141MAPKAPK20.29933129
142RPS6KA50.29695915
143AKT10.28868632
144KSR10.27179918
145GSK3B0.25862413
146MARK20.25367947

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.30213235
2Mismatch repair_Homo sapiens_hsa034304.76454036
3Spliceosome_Homo sapiens_hsa030403.57660561
4Base excision repair_Homo sapiens_hsa034103.30367505
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10581708
6RNA transport_Homo sapiens_hsa030133.07667790
7Cell cycle_Homo sapiens_hsa041102.87992927
8Ribosome_Homo sapiens_hsa030102.77818817
9Homologous recombination_Homo sapiens_hsa034402.77751403
10One carbon pool by folate_Homo sapiens_hsa006702.65337968
11Nucleotide excision repair_Homo sapiens_hsa034202.60923709
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47542352
13RNA polymerase_Homo sapiens_hsa030202.42507382
14Non-homologous end-joining_Homo sapiens_hsa034502.34132894
15mRNA surveillance pathway_Homo sapiens_hsa030152.20347145
16Pyrimidine metabolism_Homo sapiens_hsa002402.12014852
17Fanconi anemia pathway_Homo sapiens_hsa034602.09208141
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03610193
19RNA degradation_Homo sapiens_hsa030181.89416913
20Proteasome_Homo sapiens_hsa030501.64070823
21VEGF signaling pathway_Homo sapiens_hsa043701.54021117
22Systemic lupus erythematosus_Homo sapiens_hsa053221.53088345
23Other glycan degradation_Homo sapiens_hsa005111.43378207
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40304721
25Basal transcription factors_Homo sapiens_hsa030221.38206384
26p53 signaling pathway_Homo sapiens_hsa041151.35885315
27ErbB signaling pathway_Homo sapiens_hsa040121.24283414
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24228272
29Glioma_Homo sapiens_hsa052141.21659050
30Viral carcinogenesis_Homo sapiens_hsa052031.21338474
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19206000
32Epstein-Barr virus infection_Homo sapiens_hsa051691.13067882
33Antigen processing and presentation_Homo sapiens_hsa046121.09997744
34Primary immunodeficiency_Homo sapiens_hsa053401.08950764
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06700877
36Herpes simplex infection_Homo sapiens_hsa051681.05128314
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04901084
38Renal cell carcinoma_Homo sapiens_hsa052111.04681763
39Purine metabolism_Homo sapiens_hsa002301.04347544
40Prion diseases_Homo sapiens_hsa050201.04085999
41Insulin signaling pathway_Homo sapiens_hsa049101.03113640
42HTLV-I infection_Homo sapiens_hsa051661.01512193
43Thyroid cancer_Homo sapiens_hsa052160.99334818
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96445438
45Oocyte meiosis_Homo sapiens_hsa041140.92937954
46Chronic myeloid leukemia_Homo sapiens_hsa052200.88552956
47AMPK signaling pathway_Homo sapiens_hsa041520.88314013
48Selenocompound metabolism_Homo sapiens_hsa004500.88171636
49Biosynthesis of amino acids_Homo sapiens_hsa012300.87869695
50Notch signaling pathway_Homo sapiens_hsa043300.87314427
51Hepatitis C_Homo sapiens_hsa051600.85815077
52MicroRNAs in cancer_Homo sapiens_hsa052060.85154959
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84905464
54Alcoholism_Homo sapiens_hsa050340.82893360
55Colorectal cancer_Homo sapiens_hsa052100.81985735
56Lysine degradation_Homo sapiens_hsa003100.81856478
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81352325
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80224067
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.77892365
60Choline metabolism in cancer_Homo sapiens_hsa052310.76884533
61Basal cell carcinoma_Homo sapiens_hsa052170.76755072
62Estrogen signaling pathway_Homo sapiens_hsa049150.73947866
63N-Glycan biosynthesis_Homo sapiens_hsa005100.73023900
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72376365
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.71791089
66Protein export_Homo sapiens_hsa030600.69814528
67Salmonella infection_Homo sapiens_hsa051320.68441052
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.68029902
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68006740
70Small cell lung cancer_Homo sapiens_hsa052220.65880709
71Pentose phosphate pathway_Homo sapiens_hsa000300.64903095
72Endocytosis_Homo sapiens_hsa041440.64793807
73Non-small cell lung cancer_Homo sapiens_hsa052230.64651399
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63905392
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63627617
76Sulfur relay system_Homo sapiens_hsa041220.62286374
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.62248745
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.61779784
79GnRH signaling pathway_Homo sapiens_hsa049120.61344352
80Folate biosynthesis_Homo sapiens_hsa007900.60224621
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59448673
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58017585
83Hepatitis B_Homo sapiens_hsa051610.57978157
84Vibrio cholerae infection_Homo sapiens_hsa051100.57897101
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.57499299
86Inositol phosphate metabolism_Homo sapiens_hsa005620.57409682
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56235464
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55889565
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53699566
90Acute myeloid leukemia_Homo sapiens_hsa052210.53407475
91B cell receptor signaling pathway_Homo sapiens_hsa046620.52564837
92Bladder cancer_Homo sapiens_hsa052190.52134141
93Hippo signaling pathway_Homo sapiens_hsa043900.51575033
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50407491
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50158620
96Proteoglycans in cancer_Homo sapiens_hsa052050.50157600
97Measles_Homo sapiens_hsa051620.47933738
98Osteoclast differentiation_Homo sapiens_hsa043800.47591744
99Apoptosis_Homo sapiens_hsa042100.46573917
100Legionellosis_Homo sapiens_hsa051340.46288209
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.45813090
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.43797255
103Vitamin B6 metabolism_Homo sapiens_hsa007500.43443338
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42590552
105Endometrial cancer_Homo sapiens_hsa052130.42584043
106mTOR signaling pathway_Homo sapiens_hsa041500.41761666
107Axon guidance_Homo sapiens_hsa043600.41628912
108T cell receptor signaling pathway_Homo sapiens_hsa046600.40684719
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40628692
110Prostate cancer_Homo sapiens_hsa052150.38543682
111Pathways in cancer_Homo sapiens_hsa052000.37812167
112Pancreatic cancer_Homo sapiens_hsa052120.37496731
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37394886
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37132025
115Hedgehog signaling pathway_Homo sapiens_hsa043400.36986286
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.34746017
117Fructose and mannose metabolism_Homo sapiens_hsa000510.32815058
118Carbon metabolism_Homo sapiens_hsa012000.31938099
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29572922
120Wnt signaling pathway_Homo sapiens_hsa043100.29455604
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.29380238
122Influenza A_Homo sapiens_hsa051640.28706813
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28619457
124Shigellosis_Homo sapiens_hsa051310.28423989
125Viral myocarditis_Homo sapiens_hsa054160.27720494
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26954288
127HIF-1 signaling pathway_Homo sapiens_hsa040660.26636301
128Prolactin signaling pathway_Homo sapiens_hsa049170.24797230
129Galactose metabolism_Homo sapiens_hsa000520.24562321
130Adherens junction_Homo sapiens_hsa045200.22532299
131FoxO signaling pathway_Homo sapiens_hsa040680.19204441
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18624612
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18486503
134TGF-beta signaling pathway_Homo sapiens_hsa043500.17782575
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15737590
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.15023606

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »