RBM12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.83128382
2nuclear pore organization (GO:0006999)4.63726858
3nuclear pore complex assembly (GO:0051292)4.62908038
4mitotic sister chromatid cohesion (GO:0007064)4.56800774
5protein localization to kinetochore (GO:0034501)4.31586592
6establishment of integrated proviral latency (GO:0075713)4.15671947
7pre-miRNA processing (GO:0031054)4.15641505
8regulation of RNA export from nucleus (GO:0046831)4.10828137
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.99042669
10regulation of sister chromatid cohesion (GO:0007063)3.85945318
11mitotic nuclear envelope disassembly (GO:0007077)3.73794720
12sister chromatid segregation (GO:0000819)3.70713512
13kinetochore organization (GO:0051383)3.70692668
14protein localization to chromosome, centromeric region (GO:0071459)3.69809844
15DNA strand elongation involved in DNA replication (GO:0006271)3.64488929
16mitotic metaphase plate congression (GO:0007080)3.64052156
17spliceosomal tri-snRNP complex assembly (GO:0000244)3.63542734
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60346433
19DNA replication-dependent nucleosome organization (GO:0034723)3.59134271
20DNA replication-dependent nucleosome assembly (GO:0006335)3.59134271
21protein complex localization (GO:0031503)3.57140225
22negative regulation of histone methylation (GO:0031061)3.56313421
23paraxial mesoderm development (GO:0048339)3.52384116
24mitotic chromosome condensation (GO:0007076)3.51910631
25nuclear envelope disassembly (GO:0051081)3.50849460
26membrane disassembly (GO:0030397)3.50849460
27V(D)J recombination (GO:0033151)3.50252869
28negative regulation of RNA splicing (GO:0033119)3.50032338
29DNA strand elongation (GO:0022616)3.49112546
30dosage compensation (GO:0007549)3.48602035
31negative regulation of DNA repair (GO:0045738)3.48571112
32pore complex assembly (GO:0046931)3.47611890
33DNA synthesis involved in DNA repair (GO:0000731)3.47217589
34DNA geometric change (GO:0032392)3.44984757
35DNA duplex unwinding (GO:0032508)3.43338919
36DNA replication initiation (GO:0006270)3.40292211
37non-recombinational repair (GO:0000726)3.40273928
38double-strand break repair via nonhomologous end joining (GO:0006303)3.40273928
39regulation of translational fidelity (GO:0006450)3.38323042
40mitotic sister chromatid segregation (GO:0000070)3.35077505
41translesion synthesis (GO:0019985)3.34253423
42regulation of histone H3-K9 methylation (GO:0051570)3.33843119
43formation of translation preinitiation complex (GO:0001731)3.33172108
44metaphase plate congression (GO:0051310)3.31102717
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30190563
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30190563
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.30190563
48cellular protein complex localization (GO:0034629)3.27921508
49protein export from nucleus (GO:0006611)3.27887135
50DNA replication checkpoint (GO:0000076)3.27122284
51DNA ligation (GO:0006266)3.23519138
52DNA replication-independent nucleosome organization (GO:0034724)3.22874115
53DNA replication-independent nucleosome assembly (GO:0006336)3.22874115
54regulation of spindle organization (GO:0090224)3.22856898
55positive regulation of chromosome segregation (GO:0051984)3.22401292
56chromosome condensation (GO:0030261)3.20765613
57negative regulation of chromosome segregation (GO:0051985)3.20413972
58kinetochore assembly (GO:0051382)3.18926141
59spindle assembly checkpoint (GO:0071173)3.18443780
60regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18152413
61regulation of DNA damage checkpoint (GO:2000001)3.17039945
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.15568631
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15568631
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15568631
65negative regulation of sister chromatid segregation (GO:0033046)3.15568631
66mitotic spindle assembly checkpoint (GO:0007094)3.14055930
67nuclear envelope organization (GO:0006998)3.13776727
68mitotic recombination (GO:0006312)3.13167308
69negative regulation of mRNA processing (GO:0050686)3.13066604
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10788917
71mRNA transport (GO:0051028)3.09687538
72spindle checkpoint (GO:0031577)3.09233006
73regulation of chromosome segregation (GO:0051983)3.09067537
74attachment of spindle microtubules to kinetochore (GO:0008608)3.08594771
75telomere maintenance via semi-conservative replication (GO:0032201)3.08521814
76CENP-A containing nucleosome assembly (GO:0034080)3.07024794
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06115394
78chromatin assembly or disassembly (GO:0006333)3.05647105
79chromatin remodeling at centromere (GO:0031055)3.05579460
80mitotic spindle checkpoint (GO:0071174)3.03951357
81positive regulation of cell cycle checkpoint (GO:1901978)3.03393040
82regulation of mitotic sister chromatid separation (GO:0010965)3.03205975
83regulation of mitotic sister chromatid segregation (GO:0033047)3.03205975
84regulation of sister chromatid segregation (GO:0033045)3.03205975
85ATP-dependent chromatin remodeling (GO:0043044)3.02146308
86heterochromatin organization (GO:0070828)3.02071750
87regulation of DNA endoreduplication (GO:0032875)3.01230762
88regulation of mRNA stability (GO:0043488)3.00091370
89regulation of nucleobase-containing compound transport (GO:0032239)2.99105042
90DNA topological change (GO:0006265)2.98626111
91regulation of mitotic spindle organization (GO:0060236)2.98330309
92regulation of NFAT protein import into nucleus (GO:0051532)2.98303223
93telomere maintenance via recombination (GO:0000722)2.97041746
94protein localization to chromosome (GO:0034502)2.95610895
95ribosome assembly (GO:0042255)2.93149317
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93052266
97alternative mRNA splicing, via spliceosome (GO:0000380)2.92800868
98regulation of centrosome cycle (GO:0046605)2.91492065
99mRNA splicing, via spliceosome (GO:0000398)2.91290705
100RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.91290705
101regulation of centriole replication (GO:0046599)2.91237849
102sister chromatid cohesion (GO:0007062)2.90976844
103nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.90402427
104embryonic process involved in female pregnancy (GO:0060136)2.90360366
105glucocorticoid receptor signaling pathway (GO:0042921)2.90243145
106establishment of viral latency (GO:0019043)2.89979330
107DNA packaging (GO:0006323)2.89939967
108RNA splicing, via transesterification reactions (GO:0000375)2.88155542
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86953543
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.86760195
111mRNA stabilization (GO:0048255)2.86641320
112RNA stabilization (GO:0043489)2.86641320
113nucleobase biosynthetic process (GO:0046112)2.85168901
114regulation of helicase activity (GO:0051095)2.84075779
115negative regulation of mRNA metabolic process (GO:1903312)2.83728024
116establishment of chromosome localization (GO:0051303)2.83216033
117regulation of gene silencing by RNA (GO:0060966)2.83178512
118regulation of posttranscriptional gene silencing (GO:0060147)2.83178512
119regulation of gene silencing by miRNA (GO:0060964)2.83178512
120chromatin assembly (GO:0031497)2.82041073
121DNA conformation change (GO:0071103)2.81157518
122IMP biosynthetic process (GO:0006188)2.81149951
123peptidyl-arginine omega-N-methylation (GO:0035247)2.80698089
124protein-DNA complex disassembly (GO:0032986)2.79391246
125nucleosome disassembly (GO:0006337)2.79391246
126folic acid-containing compound biosynthetic process (GO:0009396)2.79360635
127postreplication repair (GO:0006301)2.77395037
128nucleic acid transport (GO:0050657)2.76433881
129establishment of RNA localization (GO:0051236)2.76433881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.79130362
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.58626963
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.63344162
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44018622
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.43985496
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88048197
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74573835
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.61385030
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60945550
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.56097429
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52038938
12MYC_22102868_ChIP-Seq_BL_Human2.44033323
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41901945
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.39577684
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38538220
16AR_21909140_ChIP-Seq_LNCAP_Human2.31725678
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28349912
18XRN2_22483619_ChIP-Seq_HELA_Human2.03077134
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02816284
20CIITA_25753668_ChIP-Seq_RAJI_Human2.01826539
21E2F7_22180533_ChIP-Seq_HELA_Human10.8060882
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90946808
23* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88692700
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87245001
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82380230
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81870406
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.72212934
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67426492
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.66790616
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66649025
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65805172
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65393403
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62889888
34TTF2_22483619_ChIP-Seq_HELA_Human1.60347929
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55322507
36VDR_23849224_ChIP-Seq_CD4+_Human1.51227842
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50071429
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47032358
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46448705
40CLOCK_20551151_ChIP-Seq_293T_Human1.45520236
41KDM5A_27292631_Chip-Seq_BREAST_Human1.44910252
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44408085
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43846731
44ELK1_19687146_ChIP-ChIP_HELA_Human1.43266401
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42416713
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.42181333
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42159057
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41722392
49FOXP3_21729870_ChIP-Seq_TREG_Human1.36770650
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36604113
51VDR_21846776_ChIP-Seq_THP-1_Human1.36492486
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36250821
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35162496
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34544116
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32181327
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30621615
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.25959812
58GABP_19822575_ChIP-Seq_HepG2_Human1.25218245
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24024751
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.23755878
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22686899
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21997513
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21711058
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21010024
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.19403398
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19327241
67DCP1A_22483619_ChIP-Seq_HELA_Human1.17749235
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16825972
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16118336
70ZNF263_19887448_ChIP-Seq_K562_Human1.16084761
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13066000
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12111882
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10814697
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10499092
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09940610
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.08951850
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07984203
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07285070
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06574465
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05853938
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05751155
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05603650
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05549474
84* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04932892
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04581425
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.04518659
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03621129
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02248241
89CHD1_26751641_Chip-Seq_LNCaP_Human1.01901603
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01566489
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01566489
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01566489
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00627320
94TFEB_21752829_ChIP-Seq_HELA_Human0.99766625
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99714555
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98746715
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97306125
98TCF7_22412390_ChIP-Seq_EML_Mouse0.96959721
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96475733
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95636145
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93362270
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93344266
103* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93017478
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.91889400
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91258189
106* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90038282
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88869633
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88868757
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88578592
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88511605
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88284978
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88151122
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86905308
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85643899
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85170548
116NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84957196
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84139109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.55789680
2MP0008057_abnormal_DNA_replication3.41345009
3MP0003111_abnormal_nucleus_morphology3.24921951
4MP0003693_abnormal_embryo_hatching3.08621722
5MP0003077_abnormal_cell_cycle2.98943950
6MP0004957_abnormal_blastocyst_morpholog2.77583186
7MP0002009_preneoplasia2.55294764
8MP0003123_paternal_imprinting2.47469918
9MP0010030_abnormal_orbit_morphology2.42682289
10MP0003121_genomic_imprinting2.39693231
11MP0010352_gastrointestinal_tract_polyps2.39532498
12MP0008058_abnormal_DNA_repair2.38447061
13MP0002877_abnormal_melanocyte_morpholog2.29983048
14MP0005076_abnormal_cell_differentiation2.28392469
15MP0008007_abnormal_cellular_replicative2.25633388
16MP0000537_abnormal_urethra_morphology2.21512187
17MP0010234_abnormal_vibrissa_follicle2.19824758
18MP0003890_abnormal_embryonic-extraembry2.09904556
19MP0001730_embryonic_growth_arrest2.09133577
20MP0000350_abnormal_cell_proliferation2.06287101
21MP0010307_abnormal_tumor_latency2.00880579
22MP0000569_abnormal_digit_pigmentation1.91739448
23MP0002084_abnormal_developmental_patter1.89977451
24MP0008932_abnormal_embryonic_tissue1.89535380
25MP0001293_anophthalmia1.88294316
26MP0002396_abnormal_hematopoietic_system1.82344740
27MP0008877_abnormal_DNA_methylation1.82292920
28MP0002085_abnormal_embryonic_tissue1.81208725
29MP0002653_abnormal_ependyma_morphology1.79966662
30MP0001672_abnormal_embryogenesis/_devel1.78487779
31MP0005380_embryogenesis_phenotype1.78487779
32MP0003221_abnormal_cardiomyocyte_apopto1.74011566
33MP0001697_abnormal_embryo_size1.73471009
34MP0004197_abnormal_fetal_growth/weight/1.71023633
35MP0002088_abnormal_embryonic_growth/wei1.67065564
36MP0003984_embryonic_growth_retardation1.66799487
37MP0004808_abnormal_hematopoietic_stem1.62200488
38MP0004264_abnormal_extraembryonic_tissu1.61343368
39MP0003122_maternal_imprinting1.59335215
40MP0004185_abnormal_adipocyte_glucose1.54815948
41MP0002086_abnormal_extraembryonic_tissu1.50482596
42MP0009697_abnormal_copulation1.49235735
43MP0009053_abnormal_anal_canal1.48632871
44MP0003937_abnormal_limbs/digits/tail_de1.47208882
45MP0002080_prenatal_lethality1.39906066
46MP0003567_abnormal_fetal_cardiomyocyte1.39051734
47MP0008789_abnormal_olfactory_epithelium1.37345775
48MP0000428_abnormal_craniofacial_morphol1.37047211
49MP0003119_abnormal_digestive_system1.34722448
50MP0003935_abnormal_craniofacial_develop1.28199591
51MP0003705_abnormal_hypodermis_morpholog1.25715458
52MP0002938_white_spotting1.25585062
53MP0003315_abnormal_perineum_morphology1.25182791
54MP0002092_abnormal_eye_morphology1.24503076
55MP0000049_abnormal_middle_ear1.23355654
56MP0003566_abnormal_cell_adhesion1.22130742
57MP0000733_abnormal_muscle_development1.20759294
58MP0009703_decreased_birth_body1.18592814
59MP0006054_spinal_hemorrhage1.17555704
60MP0001286_abnormal_eye_development1.17041921
61MP0005451_abnormal_body_composition1.16175884
62MP0002166_altered_tumor_susceptibility1.15007340
63MP0009672_abnormal_birth_weight1.14945136
64MP0002697_abnormal_eye_size1.14187041
65MP0003115_abnormal_respiratory_system1.12954773
66MP0005623_abnormal_meninges_morphology1.12309381
67MP0005187_abnormal_penis_morphology1.11698571
68MP0003861_abnormal_nervous_system1.10698415
69MP0000490_abnormal_crypts_of1.09240303
70MP0003755_abnormal_palate_morphology1.07875561
71MP0000432_abnormal_head_morphology1.07580478
72MP0000313_abnormal_cell_death1.07248294
73MP0002111_abnormal_tail_morphology1.05787481
74MP0002006_tumorigenesis1.04560641
75MP0000703_abnormal_thymus_morphology1.01667620
76MP0004133_heterotaxia1.01101979
77MP0005391_vision/eye_phenotype1.00877789
78MP0003942_abnormal_urinary_system1.00602281
79MP0006072_abnormal_retinal_apoptosis1.00503357
80MP0002932_abnormal_joint_morphology0.99945591
81MP0005501_abnormal_skin_physiology0.98272583
82MP0001849_ear_inflammation0.96500148
83MP0003385_abnormal_body_wall0.96336466
84MP0002282_abnormal_trachea_morphology0.95214336
85MP0001915_intracranial_hemorrhage0.94872518
86MP0002925_abnormal_cardiovascular_devel0.94562664
87MP0005394_taste/olfaction_phenotype0.94369046
88MP0005499_abnormal_olfactory_system0.94369046
89MP0002019_abnormal_tumor_incidence0.92715503
90MP0003941_abnormal_skin_development0.91719367
91MP0005384_cellular_phenotype0.91618847
92MP0002796_impaired_skin_barrier0.90510227
93MP0001661_extended_life_span0.89388640
94MP0006292_abnormal_olfactory_placode0.88305685
95MP0003453_abnormal_keratinocyte_physiol0.87876238
96MP0002116_abnormal_craniofacial_bone0.87637240
97MP0010678_abnormal_skin_adnexa0.85721515
98MP0009278_abnormal_bone_marrow0.85528217
99MP0001346_abnormal_lacrimal_gland0.84214001
100MP0002233_abnormal_nose_morphology0.83921337
101MP0002210_abnormal_sex_determination0.83599087
102MP0003943_abnormal_hepatobiliary_system0.83082003
103MP0003786_premature_aging0.82381083
104MP0003091_abnormal_cell_migration0.82286755
105MP0002249_abnormal_larynx_morphology0.81613331
106MP0003763_abnormal_thymus_physiology0.79849879
107MP0005248_abnormal_Harderian_gland0.78704320
108MP0003787_abnormal_imprinting0.77841308
109MP0010630_abnormal_cardiac_muscle0.77648248
110MP0000383_abnormal_hair_follicle0.77294560
111MP0002114_abnormal_axial_skeleton0.77174507
112MP0004272_abnormal_basement_membrane0.75614953
113MP0005257_abnormal_intraocular_pressure0.74798308
114MP0001145_abnormal_male_reproductive0.74186295
115MP0004233_abnormal_muscle_weight0.73633759
116MP0003938_abnormal_ear_development0.73516913
117MP0008260_abnormal_autophagy0.73358465
118MP0002081_perinatal_lethality0.72647507
119MP0000762_abnormal_tongue_morphology0.72005135
120MP0000534_abnormal_ureter_morphology0.71883369
121MP0000579_abnormal_nail_morphology0.70513724
122MP0001299_abnormal_eye_distance/0.70094406
123MP0000377_abnormal_hair_follicle0.69148932
124MP0001340_abnormal_eyelid_morphology0.69086989
125MP0002109_abnormal_limb_morphology0.68818184
126MP0002751_abnormal_autonomic_nervous0.68350152
127MP0002098_abnormal_vibrissa_morphology0.67316940
128MP0002177_abnormal_outer_ear0.67098669
129MP0001216_abnormal_epidermal_layer0.66192799
130MP0005621_abnormal_cell_physiology0.65893660
131MP0000627_abnormal_mammary_gland0.64494420

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.38213796
2Short 4th metacarpal (HP:0010044)4.38213796
3Cortical dysplasia (HP:0002539)3.23963399
4Volvulus (HP:0002580)3.20831527
5Nephroblastoma (Wilms tumor) (HP:0002667)3.20133364
6Abnormality of the labia minora (HP:0012880)3.09684150
7Medulloblastoma (HP:0002885)3.07948952
8Colon cancer (HP:0003003)3.03235399
9Abnormality of the 4th metacarpal (HP:0010012)3.00966880
10Embryonal renal neoplasm (HP:0011794)2.96633266
11Ependymoma (HP:0002888)2.81422655
12Abnormal number of incisors (HP:0011064)2.79702305
13Increased nuchal translucency (HP:0010880)2.79279138
14Asymmetry of the thorax (HP:0001555)2.61935994
15Proximal placement of thumb (HP:0009623)2.57278470
16Trigonocephaly (HP:0000243)2.55825542
17Long eyelashes (HP:0000527)2.52070643
18Deviation of the thumb (HP:0009603)2.49911731
19Neoplasm of the oral cavity (HP:0100649)2.48302265
20Facial hemangioma (HP:0000329)2.44302942
21Insidious onset (HP:0003587)2.42687066
22Termporal pattern (HP:0011008)2.42687066
23Progressive external ophthalmoplegia (HP:0000590)2.42383676
24Patellar aplasia (HP:0006443)2.39726921
25Papillary thyroid carcinoma (HP:0002895)2.39253974
26Astrocytoma (HP:0009592)2.38565415
27Abnormality of the astrocytes (HP:0100707)2.38565415
28Selective tooth agenesis (HP:0001592)2.37715484
29Leiomyosarcoma (HP:0100243)2.37458964
30Uterine leiomyosarcoma (HP:0002891)2.37458964
31Ankyloglossia (HP:0010296)2.33726464
32Birth length less than 3rd percentile (HP:0003561)2.33355902
33Ectopic kidney (HP:0000086)2.32239048
34Subacute progressive viral hepatitis (HP:0006572)2.30402264
35Prominent nose (HP:0000448)2.28587587
36Glioma (HP:0009733)2.28093844
37Abnormality of the fingertips (HP:0001211)2.26850914
38Atresia of the external auditory canal (HP:0000413)2.26010560
39Chromsome breakage (HP:0040012)2.25911820
40Aplasia/Hypoplasia of the patella (HP:0006498)2.24786299
41Congenital stationary night blindness (HP:0007642)2.22461042
42Transitional cell carcinoma of the bladder (HP:0006740)2.21550305
43Anal stenosis (HP:0002025)2.21449563
44Syringomyelia (HP:0003396)2.21390622
45Spinal cord lesions (HP:0100561)2.21390622
46Spastic diplegia (HP:0001264)2.18832766
47Hepatoblastoma (HP:0002884)2.18348946
48Aplasia/Hypoplasia of the sternum (HP:0006714)2.17922113
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.16906061
50Shoulder girdle muscle weakness (HP:0003547)2.14613244
51Abnormality of chromosome stability (HP:0003220)2.13388635
52Multiple enchondromatosis (HP:0005701)2.13058240
53Rhabdomyosarcoma (HP:0002859)2.12483910
54Neoplasm of striated muscle (HP:0009728)2.12278151
55Sparse lateral eyebrow (HP:0005338)2.10083254
56Pelvic girdle muscle weakness (HP:0003749)2.10064843
57Abnormality of abdominal situs (HP:0011620)2.09765946
58Abdominal situs inversus (HP:0003363)2.09765946
59Renal duplication (HP:0000075)2.09210374
60Degeneration of anterior horn cells (HP:0002398)2.08968687
61Abnormality of the anterior horn cell (HP:0006802)2.08968687
62Heterotopia (HP:0002282)2.08341669
63Skin tags (HP:0010609)2.05841704
64Vertebral arch anomaly (HP:0008438)2.05394595
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.05290913
66Shallow orbits (HP:0000586)2.04153547
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03536199
68Bladder carcinoma (HP:0002862)2.02935736
69Bladder neoplasm (HP:0009725)2.02935736
70Midline defect of the nose (HP:0004122)2.02732002
71Progressive muscle weakness (HP:0003323)2.01591361
72Gastrointestinal carcinoma (HP:0002672)2.01367695
73Malignant gastrointestinal tract tumors (HP:0006749)2.01367695
74Oligodactyly (HP:0012165)2.01311778
75Embryonal neoplasm (HP:0002898)1.99211933
76Cafe-au-lait spot (HP:0000957)1.99141834
77Meckel diverticulum (HP:0002245)1.97353456
78Broad thumb (HP:0011304)1.97262675
79Supernumerary ribs (HP:0005815)1.95224197
80Supernumerary bones of the axial skeleton (HP:0009144)1.95125312
81Dysmetric saccades (HP:0000641)1.94861901
82Abnormality of oral frenula (HP:0000190)1.94657447
83Skull defect (HP:0001362)1.91972456
84Reticulocytopenia (HP:0001896)1.91181951
85Abnormality of the ileum (HP:0001549)1.90764927
86Sandal gap (HP:0001852)1.89557917
87High anterior hairline (HP:0009890)1.88341043
88Preauricular skin tag (HP:0000384)1.86881587
89Small intestinal stenosis (HP:0012848)1.86212850
90Duodenal stenosis (HP:0100867)1.86212850
91Neoplasm of the pancreas (HP:0002894)1.85841061
92Basal cell carcinoma (HP:0002671)1.84886731
93Absent radius (HP:0003974)1.84848925
94Hypoplastic labia majora (HP:0000059)1.82088156
95Acute myeloid leukemia (HP:0004808)1.81915750
96Capillary hemangiomas (HP:0005306)1.80431368
97Microvesicular hepatic steatosis (HP:0001414)1.80305376
98Abnormality of the calcaneus (HP:0008364)1.80006570
99Duplication of thumb phalanx (HP:0009942)1.79281725
10011 pairs of ribs (HP:0000878)1.79113989
101Long palpebral fissure (HP:0000637)1.78691154
102Abnormality of the phalanges of the hallux (HP:0010057)1.78407953
103Obsessive-compulsive behavior (HP:0000722)1.77847066
104Increased density of long bones (HP:0006392)1.77616143
105Abnormality of the carotid arteries (HP:0005344)1.76728619
106Breast hypoplasia (HP:0003187)1.75704466
107Absent forearm bone (HP:0003953)1.75411189
108Aplasia involving forearm bones (HP:0009822)1.75411189
109Abnormal foot bone ossification (HP:0010675)1.75094780
110Cutis marmorata (HP:0000965)1.74898230
111Impulsivity (HP:0100710)1.74869704
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74693584
113Viral hepatitis (HP:0006562)1.74671270
114Abnormal lung lobation (HP:0002101)1.74566268
115Hypoplasia of the maxilla (HP:0000327)1.74554849
116Deep palmar crease (HP:0006191)1.73760855
117Insomnia (HP:0100785)1.71947481
118Septate vagina (HP:0001153)1.71787106
119Broad phalanges of the hand (HP:0009768)1.71626169
120Arnold-Chiari malformation (HP:0002308)1.70235003
121Overriding aorta (HP:0002623)1.69752072
122Aqueductal stenosis (HP:0002410)1.69437967
123Biliary tract neoplasm (HP:0100574)1.68979858
124Large earlobe (HP:0009748)1.68817586
125Increased number of teeth (HP:0011069)1.68700201
126Pendular nystagmus (HP:0012043)1.68486352
127Overlapping toe (HP:0001845)1.66886502
128Flat acetabular roof (HP:0003180)1.66512799
129Generalized hypotonia (HP:0001290)1.65370946
130Low anterior hairline (HP:0000294)1.65336512
131Deep philtrum (HP:0002002)1.65008989
132Pseudobulbar signs (HP:0002200)1.64588991
133Abnormality of the salivary glands (HP:0010286)1.64468940
134Abnormality of chromosome segregation (HP:0002916)1.64207921
135Myelodysplasia (HP:0002863)1.63638870
136Relative macrocephaly (HP:0004482)1.63463853
137Abnormality of the preputium (HP:0100587)1.63029146
138Cystic hygroma (HP:0000476)1.62961887
139Thyroid carcinoma (HP:0002890)1.61901227
140Broad palm (HP:0001169)1.61808073
141Abnormality of the duodenum (HP:0002246)1.61681777
142Bicuspid aortic valve (HP:0001647)1.61501348
143Abnormality of the musculature of the pelvis (HP:0001469)1.61371950
144Abnormality of the hip-girdle musculature (HP:0001445)1.61371950
145Hyperacusis (HP:0010780)1.61201397
146Rib fusion (HP:0000902)1.60996878
147Narrow palate (HP:0000189)1.60919728
148Acute lymphatic leukemia (HP:0006721)1.60712072
149Truncal obesity (HP:0001956)1.60399774
150Urethral obstruction (HP:0000796)1.60189832
151Abnormality of the labia majora (HP:0012881)1.60113506
152Uterine neoplasm (HP:0010784)1.59907635
153Hypospadias (HP:0000047)1.59228305
154Microtia (HP:0008551)1.58958641
155Absent thumb (HP:0009777)1.58536894
156Missing ribs (HP:0000921)1.58180350
157Optic nerve coloboma (HP:0000588)1.57908207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.59918415
2CDK124.05218109
3NEK22.98614011
4SMG12.89521840
5WEE12.72996437
6SRPK12.71460643
7MKNK12.42674796
8TAF12.30865936
9EIF2AK12.29980731
10BUB12.26282510
11MAP3K102.22113856
12NEK12.21171898
13BRD41.97775010
14ATR1.92339138
15MKNK21.88701001
16RPS6KA41.83982384
17LATS11.83820779
18TTK1.83416935
19CDK71.81166835
20EEF2K1.76068181
21PLK11.75950804
22PRPF4B1.75676911
23CHEK21.75427952
24DYRK31.74229808
25AURKB1.56640879
26PLK31.53741561
27PASK1.53349771
28TRIB31.49478591
29TSSK61.46532739
30RPS6KB21.45501917
31CHEK11.44967470
32TLK11.44364370
33CDK61.43001842
34CDK41.40089163
35KSR11.39315187
36STK101.39191439
37FGFR41.36586099
38TGFBR11.35753410
39BRSK21.34435354
40SIK31.28062308
41PNCK1.28047965
42PLK41.23867944
43CCNB11.23389248
44ATM1.18961503
45PAK41.16371137
46EIF2AK31.15731870
47SCYL21.13584859
48MTOR1.07160198
49ACVR1B1.06952077
50STK41.05784649
51FGFR11.05280746
52STK31.04190753
53ICK1.03549529
54CDK21.03066365
55PKN21.02224459
56MAP3K81.01870716
57KSR20.98613262
58VRK10.93837993
59STK38L0.91612170
60MELK0.91597592
61CAMK1D0.87035678
62ALK0.86763378
63CDK10.86094728
64FGFR30.85782732
65ERBB30.85515129
66CDK90.81596494
67TESK20.80162729
68CAMK1G0.79065714
69FGFR20.76622446
70MAP3K130.75386153
71BRAF0.74107935
72EIF2AK20.72143084
73AURKA0.71650906
74STK240.71043508
75BRSK10.69445052
76CLK10.67154927
77ERBB20.63291460
78NEK90.62079702
79MAP3K140.61921798
80PTK60.61217980
81ERBB40.59790235
82AKT30.59369859
83AKT20.58953696
84PDGFRA0.58701829
85LRRK20.57886723
86LATS20.57209598
87RAF10.56594573
88CDK80.56427899
89PRKDC0.55050887
90EPHB20.54840314
91CSNK1D0.53824117
92PAK20.53732756
93TYRO30.53059312
94MET0.52430094
95MAPK140.51732183
96ZAK0.51270639
97RPS6KA50.50879969
98MAP3K90.50474632
99MAP3K40.50372356
100UHMK10.48470872
101CSNK1E0.48185239
102CSNK2A20.47262770
103CHUK0.46686705
104DYRK20.46633684
105PIM10.46541242
106SIK20.44902850
107CSNK1A1L0.43964336
108PDGFRB0.43748035
109CDK30.43262842
110PBK0.42697962
111RPS6KB10.42408579
112YES10.40929721
113AKT10.40917520
114MAPK100.39690081
115DYRK1B0.38444515
116GSK3B0.37968833
117CDK180.37201589
118CDK11A0.36819063
119CDK150.36622894
120WNK10.36162872
121MAPK90.35945909
122MAP3K60.35064394
123BCR0.34527737
124CSNK2A10.34037720
125MAPK10.33727648
126TTN0.33323987
127CSF1R0.28928039

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.92645743
2Mismatch repair_Homo sapiens_hsa034303.40860468
3Spliceosome_Homo sapiens_hsa030403.13434709
4Cell cycle_Homo sapiens_hsa041103.01170562
5RNA transport_Homo sapiens_hsa030132.89959562
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57836387
7Base excision repair_Homo sapiens_hsa034102.42993534
8mRNA surveillance pathway_Homo sapiens_hsa030152.28658178
9Homologous recombination_Homo sapiens_hsa034402.16006142
10Nucleotide excision repair_Homo sapiens_hsa034202.11800008
11One carbon pool by folate_Homo sapiens_hsa006701.91944143
12Fanconi anemia pathway_Homo sapiens_hsa034601.89683889
13Non-homologous end-joining_Homo sapiens_hsa034501.85683444
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68368785
15Basal cell carcinoma_Homo sapiens_hsa052171.63604069
16Systemic lupus erythematosus_Homo sapiens_hsa053221.63324707
17RNA degradation_Homo sapiens_hsa030181.61211669
18MicroRNAs in cancer_Homo sapiens_hsa052061.60349378
19p53 signaling pathway_Homo sapiens_hsa041151.60340554
20RNA polymerase_Homo sapiens_hsa030201.50454791
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50295679
22Phototransduction_Homo sapiens_hsa047441.45094231
23Ribosome_Homo sapiens_hsa030101.44863721
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42804338
25Colorectal cancer_Homo sapiens_hsa052101.40720603
26Chronic myeloid leukemia_Homo sapiens_hsa052201.39825435
27Viral carcinogenesis_Homo sapiens_hsa052031.39658833
28Hippo signaling pathway_Homo sapiens_hsa043901.38909886
29Oocyte meiosis_Homo sapiens_hsa041141.37157359
30HTLV-I infection_Homo sapiens_hsa051661.33788951
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30373898
32Small cell lung cancer_Homo sapiens_hsa052221.29859948
33Notch signaling pathway_Homo sapiens_hsa043301.29600048
34Adherens junction_Homo sapiens_hsa045201.29318517
35Basal transcription factors_Homo sapiens_hsa030221.28997796
36Epstein-Barr virus infection_Homo sapiens_hsa051691.25710177
37Biosynthesis of amino acids_Homo sapiens_hsa012301.25000922
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21588709
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20921984
40TGF-beta signaling pathway_Homo sapiens_hsa043501.20615619
41Pyrimidine metabolism_Homo sapiens_hsa002401.19265342
42Herpes simplex infection_Homo sapiens_hsa051681.14604519
43Hedgehog signaling pathway_Homo sapiens_hsa043401.08399560
44Alcoholism_Homo sapiens_hsa050341.00879125
45Viral myocarditis_Homo sapiens_hsa054160.98795729
46Wnt signaling pathway_Homo sapiens_hsa043100.97075071
47Selenocompound metabolism_Homo sapiens_hsa004500.96724835
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96046737
49Steroid biosynthesis_Homo sapiens_hsa001000.94385746
50Pancreatic cancer_Homo sapiens_hsa052120.91468959
51mTOR signaling pathway_Homo sapiens_hsa041500.87927050
52Pathways in cancer_Homo sapiens_hsa052000.86711035
53Thyroid cancer_Homo sapiens_hsa052160.85436497
54Prostate cancer_Homo sapiens_hsa052150.85382542
55Hepatitis B_Homo sapiens_hsa051610.83110145
56Proteoglycans in cancer_Homo sapiens_hsa052050.82883897
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82490493
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82190569
59Endometrial cancer_Homo sapiens_hsa052130.81898002
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.81854750
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80991897
62Lysine degradation_Homo sapiens_hsa003100.78779134
63Pentose phosphate pathway_Homo sapiens_hsa000300.75862791
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75000848
65Non-small cell lung cancer_Homo sapiens_hsa052230.73449003
66Proteasome_Homo sapiens_hsa030500.69744831
67Antigen processing and presentation_Homo sapiens_hsa046120.69463362
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.68823895
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.66928612
70Inositol phosphate metabolism_Homo sapiens_hsa005620.66806567
71Acute myeloid leukemia_Homo sapiens_hsa052210.66099556
72Carbon metabolism_Homo sapiens_hsa012000.65995425
73Bladder cancer_Homo sapiens_hsa052190.64981157
74T cell receptor signaling pathway_Homo sapiens_hsa046600.63100141
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62330555
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62304575
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.62276284
78Renal cell carcinoma_Homo sapiens_hsa052110.61089821
79B cell receptor signaling pathway_Homo sapiens_hsa046620.59990624
80Apoptosis_Homo sapiens_hsa042100.59529414
81Purine metabolism_Homo sapiens_hsa002300.59306701
82Choline metabolism in cancer_Homo sapiens_hsa052310.58287318
83Primary immunodeficiency_Homo sapiens_hsa053400.58126878
84Glioma_Homo sapiens_hsa052140.56166351
85Shigellosis_Homo sapiens_hsa051310.56147240
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55855619
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54372861
88Melanoma_Homo sapiens_hsa052180.54160081
89FoxO signaling pathway_Homo sapiens_hsa040680.53359017
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.50518414
91N-Glycan biosynthesis_Homo sapiens_hsa005100.50412654
92Focal adhesion_Homo sapiens_hsa045100.50274273
93Hepatitis C_Homo sapiens_hsa051600.50160620
94AMPK signaling pathway_Homo sapiens_hsa041520.49968958
95Measles_Homo sapiens_hsa051620.48493360
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48303774
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48068461
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47084501
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46885352
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45189621
101Tight junction_Homo sapiens_hsa045300.45000634
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44526038
103HIF-1 signaling pathway_Homo sapiens_hsa040660.43548527
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.40567204
105Influenza A_Homo sapiens_hsa051640.39429246
106Axon guidance_Homo sapiens_hsa043600.39210187
107Toxoplasmosis_Homo sapiens_hsa051450.38679949
108Legionellosis_Homo sapiens_hsa051340.37393603
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37153834
110Melanogenesis_Homo sapiens_hsa049160.37037262
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36907700
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35455477
113ErbB signaling pathway_Homo sapiens_hsa040120.34012314
114Prolactin signaling pathway_Homo sapiens_hsa049170.32870811
115Rap1 signaling pathway_Homo sapiens_hsa040150.31809550
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30345620
117VEGF signaling pathway_Homo sapiens_hsa043700.29598036
118Insulin signaling pathway_Homo sapiens_hsa049100.28534405

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »