RBM12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.84785989
2nuclear pore organization (GO:0006999)6.03856324
3pre-miRNA processing (GO:0031054)5.10370365
4pore complex assembly (GO:0046931)4.89475461
5mitotic sister chromatid cohesion (GO:0007064)4.85856282
6DNA unwinding involved in DNA replication (GO:0006268)4.17755318
7sister chromatid segregation (GO:0000819)4.09745804
8regulation of centriole replication (GO:0046599)4.03629704
9negative regulation of DNA repair (GO:0045738)3.95927582
10regulation of RNA export from nucleus (GO:0046831)3.93697997
11mitotic chromosome condensation (GO:0007076)3.92092800
12mitotic sister chromatid segregation (GO:0000070)3.70258823
13regulation of histone H3-K9 methylation (GO:0051570)3.65861614
14DNA topological change (GO:0006265)3.56967220
15cytoplasmic mRNA processing body assembly (GO:0033962)3.52196147
16protein localization to kinetochore (GO:0034501)3.48910326
17protein localization to chromosome, centromeric region (GO:0071459)3.47308653
18monoubiquitinated protein deubiquitination (GO:0035520)3.42008665
19paraxial mesoderm development (GO:0048339)3.39969016
20chromatin remodeling at centromere (GO:0031055)3.23405366
21regulation of centrosome duplication (GO:0010824)3.20921587
22DNA duplex unwinding (GO:0032508)3.19276101
23CENP-A containing nucleosome assembly (GO:0034080)3.18493656
24regulation of posttranscriptional gene silencing (GO:0060147)3.13604020
25regulation of gene silencing by miRNA (GO:0060964)3.13604020
26regulation of gene silencing by RNA (GO:0060966)3.13604020
27DNA geometric change (GO:0032392)3.13536060
28regulation of centrosome cycle (GO:0046605)3.12527552
29mitotic nuclear envelope disassembly (GO:0007077)3.11534371
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09878248
31meiotic chromosome segregation (GO:0045132)3.05501866
32protein localization to chromosome (GO:0034502)3.04780529
33ATP-dependent chromatin remodeling (GO:0043044)3.03631400
34sister chromatid cohesion (GO:0007062)3.01648385
35DNA synthesis involved in DNA repair (GO:0000731)3.00824995
36kinetochore organization (GO:0051383)2.99958693
37negative regulation of histone methylation (GO:0031061)2.97454185
38regulation of nucleobase-containing compound transport (GO:0032239)2.94844264
39negative regulation of chromosome segregation (GO:0051985)2.94218129
40membrane disassembly (GO:0030397)2.93917402
41nuclear envelope disassembly (GO:0051081)2.93917402
42double-strand break repair via nonhomologous end joining (GO:0006303)2.92511992
43non-recombinational repair (GO:0000726)2.92511992
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90621748
45negative regulation of translation, ncRNA-mediated (GO:0040033)2.90621748
46regulation of translation, ncRNA-mediated (GO:0045974)2.90621748
47heterochromatin organization (GO:0070828)2.89528260
48negative regulation of mitotic sister chromatid separation (GO:2000816)2.89013037
49negative regulation of sister chromatid segregation (GO:0033046)2.89013037
50negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89013037
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89013037
52negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89013037
53DNA replication-independent nucleosome assembly (GO:0006336)2.88020084
54DNA replication-independent nucleosome organization (GO:0034724)2.88020084
55regulation of sister chromatid cohesion (GO:0007063)2.87018083
56histone H3-K36 demethylation (GO:0070544)2.86966844
57microtubule anchoring (GO:0034453)2.86687729
58regulation of mitotic sister chromatid separation (GO:0010965)2.86244579
59regulation of mitotic sister chromatid segregation (GO:0033047)2.86244579
60regulation of sister chromatid segregation (GO:0033045)2.86244579
61spindle checkpoint (GO:0031577)2.85493339
62positive regulation of cell cycle checkpoint (GO:1901978)2.81608075
63protein prenylation (GO:0018342)2.80375645
64prenylation (GO:0097354)2.80375645
65regulation of chromosome segregation (GO:0051983)2.80052392
66histone exchange (GO:0043486)2.79303723
67regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78851334
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78851334
69mitotic spindle checkpoint (GO:0071174)2.78721819
70positive regulation of developmental pigmentation (GO:0048087)2.77255346
71DNA replication initiation (GO:0006270)2.75201563
72DNA conformation change (GO:0071103)2.72563859
73histone-serine phosphorylation (GO:0035404)2.71938379
74organ growth (GO:0035265)2.71094571
75mitotic spindle assembly checkpoint (GO:0007094)2.70795671
76pyrimidine dimer repair (GO:0006290)2.67745753
77spindle assembly checkpoint (GO:0071173)2.67168275
78histone H3-K9 methylation (GO:0051567)2.66571299
79V(D)J recombination (GO:0033151)2.66395198
80somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66172901
81somatic hypermutation of immunoglobulin genes (GO:0016446)2.66172901
82DNA replication checkpoint (GO:0000076)2.64885269
83glucocorticoid receptor signaling pathway (GO:0042921)2.64822744
84regulation of NFAT protein import into nucleus (GO:0051532)2.64635905
85positive regulation of RNA splicing (GO:0033120)2.62344958
86regulation of DNA damage checkpoint (GO:2000001)2.62199092
87metaphase plate congression (GO:0051310)2.61555511
88DNA replication-dependent nucleosome assembly (GO:0006335)2.59386075
89DNA replication-dependent nucleosome organization (GO:0034723)2.59386075
90dosage compensation (GO:0007549)2.58994843
91peptidyl-lysine trimethylation (GO:0018023)2.58392598
92DNA strand elongation involved in DNA replication (GO:0006271)2.58267631
93stress granule assembly (GO:0034063)2.58045560
94nucleus organization (GO:0006997)2.57210558
95mitotic metaphase plate congression (GO:0007080)2.55786049
96interkinetic nuclear migration (GO:0022027)2.55269073
97mitotic G2/M transition checkpoint (GO:0044818)2.54365302
98regulation of DNA endoreduplication (GO:0032875)2.53363818
99microtubule depolymerization (GO:0007019)2.53164076
100peptidyl-threonine dephosphorylation (GO:0035970)2.52909688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.79945767
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.63260841
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99128994
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.75256066
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.73972670
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.29999757
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53692540
8FUS_26573619_Chip-Seq_HEK293_Human2.47754014
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46098938
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38257911
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.33019291
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26810212
13EWS_26573619_Chip-Seq_HEK293_Human2.21979011
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21190593
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17326080
16* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10712042
17GATA1_22025678_ChIP-Seq_K562_Human2.06017532
18TAF15_26573619_Chip-Seq_HEK293_Human2.02894456
19AR_21909140_ChIP-Seq_LNCAP_Human2.01848866
20* ELK1_19687146_ChIP-ChIP_HELA_Human1.94522955
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90658420
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85722816
23IGF1R_20145208_ChIP-Seq_DFB_Human1.76699193
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66333660
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64495435
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59488423
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58190961
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.56824929
29ZNF274_21170338_ChIP-Seq_K562_Hela1.50878276
30SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49382247
31SOX2_16153702_ChIP-ChIP_HESCs_Human1.47257116
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46266483
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.43413491
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38441818
35GBX2_23144817_ChIP-Seq_PC3_Human1.38371603
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37804084
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37600658
38MYC_18940864_ChIP-ChIP_HL60_Human1.33312771
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32455340
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29128316
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28079294
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.27735484
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27511893
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27486044
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26933381
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26027682
47VDR_22108803_ChIP-Seq_LS180_Human1.24163131
48IRF1_19129219_ChIP-ChIP_H3396_Human1.23030722
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20661656
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18100382
51SOX9_26525672_Chip-Seq_HEART_Mouse1.17866531
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17758123
53P300_19829295_ChIP-Seq_ESCs_Human1.17355093
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17309306
55STAT3_23295773_ChIP-Seq_U87_Human1.16815872
56TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16534023
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.16179281
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16162414
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15468896
60ER_23166858_ChIP-Seq_MCF-7_Human1.13294984
61EZH2_22144423_ChIP-Seq_EOC_Human1.12399744
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09992663
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09739578
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08136094
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07784365
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07784365
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07784365
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.07513226
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06211525
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04922415
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04835196
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.04540718
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03913393
74* VDR_23849224_ChIP-Seq_CD4+_Human1.03826101
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03274416
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.02090830
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01470200
78PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01431962
79TTF2_22483619_ChIP-Seq_HELA_Human1.00756773
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00461598
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00050845
82SMAD4_21799915_ChIP-Seq_A2780_Human0.99625787
83KDM5A_27292631_Chip-Seq_BREAST_Human0.98979521
84CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97874951
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96791976
86POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96345257
87MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95061658
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.94393097
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94375129
90RNF2_27304074_Chip-Seq_NSC_Mouse0.94315928
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93640830
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93640830
93CHD1_26751641_Chip-Seq_LNCaP_Human0.93490672
94AR_21572438_ChIP-Seq_LNCaP_Human0.93098264
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91940614
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91792835
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91768729
98FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89653679
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88086960
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.85445750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.02850385
2MP0000569_abnormal_digit_pigmentation3.20121191
3MP0002009_preneoplasia3.16369711
4MP0010094_abnormal_chromosome_stability3.11231474
5MP0003890_abnormal_embryonic-extraembry2.90514229
6MP0003111_abnormal_nucleus_morphology2.69266516
7MP0003077_abnormal_cell_cycle2.59405904
8MP0004957_abnormal_blastocyst_morpholog2.29781488
9MP0003693_abnormal_embryo_hatching2.20335708
10MP0008058_abnormal_DNA_repair2.16061198
11MP0003937_abnormal_limbs/digits/tail_de2.11168781
12MP0008877_abnormal_DNA_methylation1.96383148
13MP0005187_abnormal_penis_morphology1.93367386
14MP0005248_abnormal_Harderian_gland1.92025421
15MP0002697_abnormal_eye_size1.88063978
16MP0001293_anophthalmia1.86273630
17MP0009697_abnormal_copulation1.70495746
18MP0001286_abnormal_eye_development1.69949892
19MP0010307_abnormal_tumor_latency1.68321650
20MP0002084_abnormal_developmental_patter1.67418974
21MP0005380_embryogenesis_phenotype1.65717329
22MP0001672_abnormal_embryogenesis/_devel1.65717329
23MP0004197_abnormal_fetal_growth/weight/1.64760831
24MP0003984_embryonic_growth_retardation1.64604788
25MP0009672_abnormal_birth_weight1.62957630
26MP0002088_abnormal_embryonic_growth/wei1.61834465
27MP0003136_yellow_coat_color1.61216475
28MP0006292_abnormal_olfactory_placode1.59936670
29MP0010352_gastrointestinal_tract_polyps1.59827433
30MP0003567_abnormal_fetal_cardiomyocyte1.53912100
31MP0004133_heterotaxia1.53526148
32MP0008932_abnormal_embryonic_tissue1.51261105
33MP0000537_abnormal_urethra_morphology1.48887618
34MP0009703_decreased_birth_body1.48256564
35MP0003941_abnormal_skin_development1.45931685
36MP0001299_abnormal_eye_distance/1.45874199
37MP0000428_abnormal_craniofacial_morphol1.45513799
38MP0001346_abnormal_lacrimal_gland1.44156993
39MP0002085_abnormal_embryonic_tissue1.43366463
40MP0000350_abnormal_cell_proliferation1.41833020
41MP0000778_abnormal_nervous_system1.41431373
42MP0003121_genomic_imprinting1.40952087
43MP0002233_abnormal_nose_morphology1.35797585
44MP0004808_abnormal_hematopoietic_stem1.35565946
45MP0000383_abnormal_hair_follicle1.32957293
46MP0001697_abnormal_embryo_size1.32927620
47MP0003861_abnormal_nervous_system1.32456047
48MP0001730_embryonic_growth_arrest1.29914296
49MP0000647_abnormal_sebaceous_gland1.28881346
50MP0003935_abnormal_craniofacial_develop1.27351548
51MP0000566_synostosis1.26725560
52MP0002092_abnormal_eye_morphology1.25756913
53MP0005076_abnormal_cell_differentiation1.24918362
54MP0003385_abnormal_body_wall1.22953006
55MP0003943_abnormal_hepatobiliary_system1.21584774
56MP0000631_abnormal_neuroendocrine_gland1.21451642
57MP0003315_abnormal_perineum_morphology1.21255125
58MP0002086_abnormal_extraembryonic_tissu1.16718620
59MP0010678_abnormal_skin_adnexa1.14824172
60MP0003119_abnormal_digestive_system1.14113178
61MP0008007_abnormal_cellular_replicative1.13440912
62MP0005220_abnormal_exocrine_pancreas1.10838728
63MP0003221_abnormal_cardiomyocyte_apopto1.09879672
64MP0002396_abnormal_hematopoietic_system1.08335765
65MP0003755_abnormal_palate_morphology1.07893160
66MP0002080_prenatal_lethality1.07410274
67MP0002160_abnormal_reproductive_system1.06684652
68MP0003787_abnormal_imprinting1.05073738
69MP0002928_abnormal_bile_duct1.04022837
70MP0002111_abnormal_tail_morphology1.02904379
71MP0000432_abnormal_head_morphology1.01736525
72MP0003115_abnormal_respiratory_system0.99916639
73MP0001529_abnormal_vocalization0.99598169
74MP0008995_early_reproductive_senescence0.97391720
75MP0002938_white_spotting0.93354199
76MP0002210_abnormal_sex_determination0.92697023
77MP0001929_abnormal_gametogenesis0.91846298
78MP0005391_vision/eye_phenotype0.91351514
79MP0001145_abnormal_male_reproductive0.90290384
80MP0003942_abnormal_urinary_system0.89796774
81MP0005394_taste/olfaction_phenotype0.89453586
82MP0005499_abnormal_olfactory_system0.89453586
83MP0003122_maternal_imprinting0.89020971
84MP0006072_abnormal_retinal_apoptosis0.88474167
85MP0002751_abnormal_autonomic_nervous0.86722256
86MP0003632_abnormal_nervous_system0.85998410
87MP0001188_hyperpigmentation0.83611340
88MP0002081_perinatal_lethality0.83198907
89MP0000427_abnormal_hair_cycle0.83065838
90MP0002152_abnormal_brain_morphology0.81380295
91MP0000653_abnormal_sex_gland0.80715899
92MP0002184_abnormal_innervation0.80536727
93MP0000313_abnormal_cell_death0.78746848
94MP0004233_abnormal_muscle_weight0.77716495
95MP0003698_abnormal_male_reproductive0.76632255
96MP0010030_abnormal_orbit_morphology0.74559443
97MP0003718_maternal_effect0.74461358
98MP0000955_abnormal_spinal_cord0.74112694
99MP0008961_abnormal_basal_metabolism0.73309202
100MP0000049_abnormal_middle_ear0.71763731

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.88027118
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14088044
3Chromsome breakage (HP:0040012)3.06108070
4Cortical dysplasia (HP:0002539)2.98592033
5Papillary thyroid carcinoma (HP:0002895)2.89850429
6Acute lymphatic leukemia (HP:0006721)2.64467497
7Hepatoblastoma (HP:0002884)2.62832971
8Increased nuchal translucency (HP:0010880)2.62638735
9Abnormality of chromosome stability (HP:0003220)2.59712143
10High anterior hairline (HP:0009890)2.55615112
11Medulloblastoma (HP:0002885)2.54189671
12Rhabdomyosarcoma (HP:0002859)2.52498851
13Genetic anticipation (HP:0003743)2.38872808
14Nephroblastoma (Wilms tumor) (HP:0002667)2.36435061
15Partial agenesis of the corpus callosum (HP:0001338)2.27621180
16Absent radius (HP:0003974)2.27021184
17Colon cancer (HP:0003003)2.25213202
18Poor coordination (HP:0002370)2.23028000
19Embryonal renal neoplasm (HP:0011794)2.22434573
20Absent forearm bone (HP:0003953)2.17441775
21Aplasia involving forearm bones (HP:0009822)2.17441775
22Oligodactyly (hands) (HP:0001180)2.15383412
23Deep philtrum (HP:0002002)2.14985670
24Truncal obesity (HP:0001956)2.11043801
25Missing ribs (HP:0000921)2.10620613
26Sandal gap (HP:0001852)2.06764998
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.06494111
28Neoplasm of striated muscle (HP:0009728)2.06208139
29Thyroid carcinoma (HP:0002890)2.05965489
30Meckel diverticulum (HP:0002245)2.04763702
31Overlapping toe (HP:0001845)2.04021305
32Abnormality of the labia minora (HP:0012880)2.03896980
33Heterotopia (HP:0002282)2.01508503
34Aqueductal stenosis (HP:0002410)1.98104196
35Abnormality of the ileum (HP:0001549)1.96476284
36Aplasia/Hypoplasia of the sternum (HP:0006714)1.96326238
37Sloping forehead (HP:0000340)1.95889829
38Midline defect of the nose (HP:0004122)1.95524460
39Transitional cell carcinoma of the bladder (HP:0006740)1.91987344
40Genital tract atresia (HP:0001827)1.91348882
41Vaginal atresia (HP:0000148)1.90512937
42Ectopic kidney (HP:0000086)1.88307890
43Acute myeloid leukemia (HP:0004808)1.88305032
44Cystic hygroma (HP:0000476)1.87897264
45Gastrointestinal carcinoma (HP:0002672)1.87382129
46Malignant gastrointestinal tract tumors (HP:0006749)1.87382129
47Protruding tongue (HP:0010808)1.86014889
48Abnormal lung lobation (HP:0002101)1.85833131
49Leiomyosarcoma (HP:0100243)1.85808740
50Uterine leiomyosarcoma (HP:0002891)1.85808740
51Drooling (HP:0002307)1.84690504
52Congenital primary aphakia (HP:0007707)1.83463962
53Supernumerary spleens (HP:0009799)1.82717484
54Curly hair (HP:0002212)1.82467055
55Neoplasm of the oral cavity (HP:0100649)1.81735978
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80948269
57Short 4th metacarpal (HP:0010044)1.80948269
58Gait imbalance (HP:0002141)1.79185217
59Tubulointerstitial nephritis (HP:0001970)1.78725126
60Bladder carcinoma (HP:0002862)1.75758351
61Bladder neoplasm (HP:0009725)1.75758351
62Duplication of thumb phalanx (HP:0009942)1.75713956
63Obsessive-compulsive behavior (HP:0000722)1.75532421
64Abnormality of chromosome segregation (HP:0002916)1.75139695
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.74339151
66Dysmetric saccades (HP:0000641)1.72633625
67Low anterior hairline (HP:0000294)1.72402076
68Degeneration of the lateral corticospinal tracts (HP:0002314)1.69999392
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69999392
70Birth length less than 3rd percentile (HP:0003561)1.69066587
71Nephrogenic diabetes insipidus (HP:0009806)1.68556288
72Coarctation of aorta (HP:0001680)1.68159074
73Skull defect (HP:0001362)1.68148904
74Intestinal atresia (HP:0011100)1.65647264
75Abnormality of the ischium (HP:0003174)1.63867425
76Abnormality of the preputium (HP:0100587)1.62971027
77Excessive salivation (HP:0003781)1.62930940
78Absent eyebrow (HP:0002223)1.62696074
79Cutaneous finger syndactyly (HP:0010554)1.62159332
80Glioma (HP:0009733)1.61554655
81Vertebral clefting (HP:0008428)1.61433865
82Hemivertebrae (HP:0002937)1.61353128
83Cerebellar dysplasia (HP:0007033)1.60687029
84Cupped ear (HP:0000378)1.60595559
85Thick eyebrow (HP:0000574)1.60412893
86Fibular hypoplasia (HP:0003038)1.60389279
87Abnormality of the septum pellucidum (HP:0007375)1.59840541
88Urethral obstruction (HP:0000796)1.59687168
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59518214
90Vertebral arch anomaly (HP:0008438)1.58988655
91Esophageal atresia (HP:0002032)1.58868157
92Omphalocele (HP:0001539)1.58817209
93Micropenis (HP:0000054)1.58019856
94Small intestinal stenosis (HP:0012848)1.57959294
95Duodenal stenosis (HP:0100867)1.57959294
96Highly arched eyebrow (HP:0002553)1.57118258
97Insidious onset (HP:0003587)1.56991490
98Termporal pattern (HP:0011008)1.56991490
99Abnormality of the carotid arteries (HP:0005344)1.56277742
100Oligodactyly (HP:0012165)1.55918429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.04188192
2MAP3K102.96936999
3SRPK12.96659865
4CDK122.92366131
5CDC72.69800454
6MKNK22.61738105
7MKNK12.55904305
8LATS12.37829589
9TTK2.08634830
10MAP3K42.03587874
11BRSK22.03168841
12WEE12.01380246
13NEK21.88109261
14PNCK1.83971876
15TNIK1.77202768
16BCR1.65135953
17NLK1.61189574
18ERBB31.60083852
19BMPR1B1.59319984
20CASK1.58395939
21PLK41.54874216
22ZAK1.48962013
23EEF2K1.47962096
24ACVR1B1.44891883
25CAMK1G1.44194489
26CDK61.38003959
27TAF11.35554788
28FGFR21.34693937
29PBK1.31355786
30CDK31.29866484
31DYRK31.27942924
32AKT31.24564417
33BUB11.23674206
34CHEK21.20528522
35STK38L1.20196995
36FGFR11.18585929
37ATR1.18367726
38SGK21.16456655
39FRK1.16111156
40PASK1.15927123
41TSSK61.12074257
42RPS6KA41.11740405
43CAMK1D1.11704450
44STK31.08383757
45PLK11.05466132
46PLK31.04522611
47MAP2K71.02625283
48ATM1.02059423
49YES11.01684504
50CHEK10.98037343
51EIF2AK30.95590345
52NTRK20.91256316
53SCYL20.89248511
54AURKB0.85220286
55WNK30.84866392
56RPS6KB20.84738254
57CDK40.83936582
58PKN20.81014566
59FLT30.80624589
60TGFBR10.75981343
61DYRK1A0.74879941
62WNK10.73187822
63CSNK1G10.72572321
64SGK2230.71611183
65SGK4940.71611183
66MELK0.71553423
67CDK20.68811491
68CDK10.68162839
69MET0.67571873
70NUAK10.67145042
71PDGFRA0.67079622
72MAP2K40.65769177
73SGK30.64484242
74DYRK1B0.63329351
75STK40.63221184
76CDK70.62840218
77MAP3K70.60349936
78ERBB40.59605118
79WNK40.59250082
80KSR10.57196433
81EIF2AK20.56533522
82NEK10.53609292
83PLK20.53530167
84RPS6KB10.52056976
85MTOR0.49860393
86STK390.49324112
87CSNK1E0.49322093
88ICK0.48229029
89GSK3B0.47853868
90CLK10.47600427
91VRK10.47427126
92SGK10.44876464
93MAP4K20.44068655
94MAPK100.42257005
95PRKAA10.42128182
96PIM10.41658144
97TLK10.41638479
98CAMK40.40949772
99FGFR30.40918713
100MAPK140.39879053

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.28278003
2Cell cycle_Homo sapiens_hsa041102.82078103
3mRNA surveillance pathway_Homo sapiens_hsa030152.72271690
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61361351
5RNA transport_Homo sapiens_hsa030132.57971878
6DNA replication_Homo sapiens_hsa030302.57804551
7Fanconi anemia pathway_Homo sapiens_hsa034602.52633102
8Mismatch repair_Homo sapiens_hsa034302.45620904
9Spliceosome_Homo sapiens_hsa030402.30946771
10Homologous recombination_Homo sapiens_hsa034402.10486073
11Lysine degradation_Homo sapiens_hsa003101.93630125
12Basal transcription factors_Homo sapiens_hsa030221.84961765
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76660215
14RNA degradation_Homo sapiens_hsa030181.76601761
15Nucleotide excision repair_Homo sapiens_hsa034201.76100199
16Selenocompound metabolism_Homo sapiens_hsa004501.75598865
17Alcoholism_Homo sapiens_hsa050341.69017206
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.67307856
19MicroRNAs in cancer_Homo sapiens_hsa052061.59935170
20Basal cell carcinoma_Homo sapiens_hsa052171.59652871
21Hedgehog signaling pathway_Homo sapiens_hsa043401.56956061
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54500597
23p53 signaling pathway_Homo sapiens_hsa041151.49815923
24Hippo signaling pathway_Homo sapiens_hsa043901.40821542
25One carbon pool by folate_Homo sapiens_hsa006701.37464040
26Colorectal cancer_Homo sapiens_hsa052101.37392248
27Thyroid cancer_Homo sapiens_hsa052161.36486524
28Oocyte meiosis_Homo sapiens_hsa041141.33358645
29Systemic lupus erythematosus_Homo sapiens_hsa053221.33213550
30Adherens junction_Homo sapiens_hsa045201.32456415
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29805197
32Prostate cancer_Homo sapiens_hsa052151.26939960
33Base excision repair_Homo sapiens_hsa034101.25495929
34Wnt signaling pathway_Homo sapiens_hsa043101.22274013
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20173392
36TGF-beta signaling pathway_Homo sapiens_hsa043501.19627441
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14814453
38Circadian rhythm_Homo sapiens_hsa047101.14774575
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13142845
40Viral carcinogenesis_Homo sapiens_hsa052031.09066742
41Endometrial cancer_Homo sapiens_hsa052131.08917895
42Chronic myeloid leukemia_Homo sapiens_hsa052201.04748075
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02930384
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98506039
45Non-small cell lung cancer_Homo sapiens_hsa052230.97523027
46ErbB signaling pathway_Homo sapiens_hsa040120.97237490
47Nicotine addiction_Homo sapiens_hsa050330.93640628
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93480533
49Small cell lung cancer_Homo sapiens_hsa052220.92669630
50Axon guidance_Homo sapiens_hsa043600.88669978
51FoxO signaling pathway_Homo sapiens_hsa040680.88546470
52Fatty acid biosynthesis_Homo sapiens_hsa000610.88516035
53Inositol phosphate metabolism_Homo sapiens_hsa005620.87748330
54Renal cell carcinoma_Homo sapiens_hsa052110.83498495
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.82649936
56mTOR signaling pathway_Homo sapiens_hsa041500.82005289
57Taste transduction_Homo sapiens_hsa047420.80891708
58Pancreatic cancer_Homo sapiens_hsa052120.79167985
59RNA polymerase_Homo sapiens_hsa030200.76131428
60AMPK signaling pathway_Homo sapiens_hsa041520.73635040
61Steroid biosynthesis_Homo sapiens_hsa001000.72896082
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.71904728
63Melanoma_Homo sapiens_hsa052180.70211441
64Pathways in cancer_Homo sapiens_hsa052000.70073371
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67895549
66Choline metabolism in cancer_Homo sapiens_hsa052310.64749457
67Type II diabetes mellitus_Homo sapiens_hsa049300.63820629
68Glioma_Homo sapiens_hsa052140.62884742
69Long-term depression_Homo sapiens_hsa047300.62619720
70Prolactin signaling pathway_Homo sapiens_hsa049170.61455127
71Glucagon signaling pathway_Homo sapiens_hsa049220.60968690
72Melanogenesis_Homo sapiens_hsa049160.60556444
73Tight junction_Homo sapiens_hsa045300.58947328
74Vitamin B6 metabolism_Homo sapiens_hsa007500.57828984
75Gap junction_Homo sapiens_hsa045400.57412111
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54550733
77Propanoate metabolism_Homo sapiens_hsa006400.53916478
78Insulin signaling pathway_Homo sapiens_hsa049100.53757586
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53293424
80Long-term potentiation_Homo sapiens_hsa047200.51603255
81Hepatitis B_Homo sapiens_hsa051610.51516372
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.47160978
83Dorso-ventral axis formation_Homo sapiens_hsa043200.47019786
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45877268
85Cholinergic synapse_Homo sapiens_hsa047250.45320140
86Purine metabolism_Homo sapiens_hsa002300.45301745
87Proteoglycans in cancer_Homo sapiens_hsa052050.44052274
88Biosynthesis of amino acids_Homo sapiens_hsa012300.41438980
89Dopaminergic synapse_Homo sapiens_hsa047280.40691550
90Estrogen signaling pathway_Homo sapiens_hsa049150.39156929
91Glutamatergic synapse_Homo sapiens_hsa047240.37415121
92ABC transporters_Homo sapiens_hsa020100.36251472
93Pyrimidine metabolism_Homo sapiens_hsa002400.35691569
94HTLV-I infection_Homo sapiens_hsa051660.34974842
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33386548
96Nitrogen metabolism_Homo sapiens_hsa009100.32995677
97Notch signaling pathway_Homo sapiens_hsa043300.32950552
98Amphetamine addiction_Homo sapiens_hsa050310.31772643
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31753665
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30329512

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