RBM14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.66905267
2DNA strand elongation involved in DNA replication (GO:0006271)4.89382908
3protein localization to kinetochore (GO:0034501)4.67310150
4DNA strand elongation (GO:0022616)4.64379773
5DNA replication initiation (GO:0006270)4.64232052
6telomere maintenance via semi-conservative replication (GO:0032201)4.32670262
7mitotic nuclear envelope disassembly (GO:0007077)4.14121471
8folic acid-containing compound biosynthetic process (GO:0009396)4.10621567
9spliceosomal tri-snRNP complex assembly (GO:0000244)4.05545963
10formation of translation preinitiation complex (GO:0001731)4.01730038
11protein localization to chromosome, centromeric region (GO:0071459)4.00451774
12DNA replication checkpoint (GO:0000076)3.99487632
13DNA replication-dependent nucleosome assembly (GO:0006335)3.97292288
14DNA replication-dependent nucleosome organization (GO:0034723)3.97292288
15nucleobase biosynthetic process (GO:0046112)3.88983020
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.87592260
17nuclear envelope disassembly (GO:0051081)3.82783052
18membrane disassembly (GO:0030397)3.82783052
19mitotic sister chromatid segregation (GO:0000070)3.80648461
20IMP biosynthetic process (GO:0006188)3.79960927
21maturation of SSU-rRNA (GO:0030490)3.78450524
22nuclear pore organization (GO:0006999)3.77853150
23telomere maintenance via recombination (GO:0000722)3.74858462
24DNA topological change (GO:0006265)3.74583489
25mitotic metaphase plate congression (GO:0007080)3.71979370
26mitotic recombination (GO:0006312)3.65072891
273-UTR-mediated mRNA stabilization (GO:0070935)3.62096356
28DNA duplex unwinding (GO:0032508)3.61997621
29DNA geometric change (GO:0032392)3.59476524
30ribosomal small subunit assembly (GO:0000028)3.58900489
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57333536
32telomere maintenance via telomere lengthening (GO:0010833)3.56631324
33negative regulation of RNA splicing (GO:0033119)3.55796056
34sister chromatid segregation (GO:0000819)3.54398836
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.53799568
36nucleosome disassembly (GO:0006337)3.50012763
37protein-DNA complex disassembly (GO:0032986)3.50012763
38nuclear pore complex assembly (GO:0051292)3.48791474
39proline biosynthetic process (GO:0006561)3.47944534
40viral transcription (GO:0019083)3.46967491
41mitotic chromosome condensation (GO:0007076)3.46670324
42peptidyl-arginine methylation (GO:0018216)3.43254911
43peptidyl-arginine N-methylation (GO:0035246)3.43254911
44purine nucleobase biosynthetic process (GO:0009113)3.39462318
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.38057168
46translational termination (GO:0006415)3.37858868
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35734498
48heterochromatin organization (GO:0070828)3.34368252
49establishment of viral latency (GO:0019043)3.32546491
50negative regulation of mRNA processing (GO:0050686)3.31093626
51metaphase plate congression (GO:0051310)3.30771459
52pentose-phosphate shunt (GO:0006098)3.30417500
53DNA deamination (GO:0045006)3.30007246
54ribosome biogenesis (GO:0042254)3.29845745
55regulation of posttranscriptional gene silencing (GO:0060147)3.29461670
56regulation of gene silencing by miRNA (GO:0060964)3.29461670
57regulation of gene silencing by RNA (GO:0060966)3.29461670
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28327154
59IMP metabolic process (GO:0046040)3.27519055
60translational initiation (GO:0006413)3.23767831
61DNA replication-independent nucleosome assembly (GO:0006336)3.23508005
62DNA replication-independent nucleosome organization (GO:0034724)3.23508005
63pre-miRNA processing (GO:0031054)3.22449253
64translational elongation (GO:0006414)3.19830056
65chromatin remodeling at centromere (GO:0031055)3.19158804
66protein complex localization (GO:0031503)3.19098235
67CENP-A containing nucleosome assembly (GO:0034080)3.18906087
68regulation of spindle organization (GO:0090224)3.17596094
69peptidyl-arginine omega-N-methylation (GO:0035247)3.17387693
70chromosome condensation (GO:0030261)3.15036895
71spliceosomal snRNP assembly (GO:0000387)3.14773032
72Golgi transport vesicle coating (GO:0048200)3.13232125
73COPI coating of Golgi vesicle (GO:0048205)3.13232125
74ribonucleoprotein complex biogenesis (GO:0022613)3.12905065
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12503104
76RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11680594
77mRNA splicing, via spliceosome (GO:0000398)3.11680594
78pore complex assembly (GO:0046931)3.10467634
79RNA splicing, via transesterification reactions (GO:0000375)3.10391967
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.09888722
81somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08175680
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.08175680
83ribosome assembly (GO:0042255)3.07652171
84negative regulation of erythrocyte differentiation (GO:0045647)3.07256153
85rRNA transcription (GO:0009303)3.06952416
86DNA synthesis involved in DNA repair (GO:0000731)3.06425607
87kinetochore organization (GO:0051383)3.05992288
88chromatin assembly or disassembly (GO:0006333)3.05938769
89ribosomal large subunit biogenesis (GO:0042273)3.05740008
90positive regulation of chromosome segregation (GO:0051984)3.04748715
91nuclear envelope organization (GO:0006998)3.02624222
92RNA stabilization (GO:0043489)3.00131173
93mRNA stabilization (GO:0048255)3.00131173
94attachment of spindle microtubules to kinetochore (GO:0008608)2.99689374
95ribosomal small subunit biogenesis (GO:0042274)2.99446231
96establishment of chromosome localization (GO:0051303)2.99410825
97termination of RNA polymerase II transcription (GO:0006369)2.99274983
98nuclear envelope reassembly (GO:0031468)2.98830469
99mitotic nuclear envelope reassembly (GO:0007084)2.98830469
100apoptotic process involved in morphogenesis (GO:0060561)2.98592945
101negative regulation of mRNA metabolic process (GO:1903312)2.98444144
102cellular protein complex localization (GO:0034629)2.98426414
103base-excision repair (GO:0006284)2.97095793
104negative regulation of chromosome segregation (GO:0051985)2.96988730
105DNA conformation change (GO:0071103)2.96724091
106dosage compensation (GO:0007549)2.96298193
107protein localization to chromosome (GO:0034502)2.95884579
108translesion synthesis (GO:0019985)2.95674142
109regulation of chromatin binding (GO:0035561)2.95136016
110regulation of histone H3-K9 methylation (GO:0051570)2.94238177
111V(D)J recombination (GO:0033151)2.93945391
112chromatin assembly (GO:0031497)2.93704959
113folic acid metabolic process (GO:0046655)2.93529012
114negative regulation of histone methylation (GO:0031061)2.93388510
115regulation of translational fidelity (GO:0006450)2.92491535
116histone arginine methylation (GO:0034969)2.92396558
117regulation of chromosome segregation (GO:0051983)2.92007158
118* intracellular estrogen receptor signaling pathway (GO:0030520)2.90397068
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88190110
120negative regulation of sister chromatid segregation (GO:0033046)2.88190110
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.88190110
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88190110
123spindle assembly checkpoint (GO:0071173)2.87158249
124rRNA processing (GO:0006364)2.87130341
125histone H2A acetylation (GO:0043968)2.85699277
126mitotic spindle assembly checkpoint (GO:0007094)2.84636896
127snRNA metabolic process (GO:0016073)2.84597338
128ATP-dependent chromatin remodeling (GO:0043044)2.82847567
129establishment of integrated proviral latency (GO:0075713)2.82543085
130cellular response to interleukin-4 (GO:0071353)2.81593595
131regulation of NFAT protein import into nucleus (GO:0051532)2.80358455
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79575890
133kinetochore assembly (GO:0051382)2.79243796
134rRNA metabolic process (GO:0016072)2.79178806
135NADPH regeneration (GO:0006740)2.78669465
136GDP-mannose metabolic process (GO:0019673)2.74517994
137regulation of RNA export from nucleus (GO:0046831)2.73309031
138DNA packaging (GO:0006323)2.69264920
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65339636
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.61919986
141glucose catabolic process (GO:0006007)2.61902958
142pentose metabolic process (GO:0019321)2.61748774
143histone H4-K8 acetylation (GO:0043982)2.61323035
144histone H4-K5 acetylation (GO:0043981)2.61323035
145mRNA export from nucleus (GO:0006406)2.60533957
146viral mRNA export from host cell nucleus (GO:0046784)2.60455859
147mitochondrial fusion (GO:0008053)2.60449075
148mitotic G1 DNA damage checkpoint (GO:0031571)2.60143346
149negative regulation of cell size (GO:0045792)2.58178297
150histone H3-K36 demethylation (GO:0070544)2.56543393
151epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55855136
152regulation of mRNA stability (GO:0043488)2.54669595
153regulation of translational termination (GO:0006449)2.52905482
154protein export from nucleus (GO:0006611)2.52671531
155mRNA transport (GO:0051028)2.51943743
156tRNA methylation (GO:0030488)2.50772459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.54515920
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.43145795
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.89984340
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64261776
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43071380
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08117603
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89308793
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61742529
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57347070
10MYC_22102868_ChIP-Seq_BL_Human2.49936247
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.38506096
12* XRN2_22483619_ChIP-Seq_HELA_Human2.31082860
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.28814770
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.27421446
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16035654
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13388749
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12327936
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11716203
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10121125
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02066517
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.98964857
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93805089
23CIITA_25753668_ChIP-Seq_RAJI_Human1.91661950
24AR_21909140_ChIP-Seq_LNCAP_Human1.87914704
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.87080952
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80436204
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79796932
28LXR_22292898_ChIP-Seq_THP-1_Human1.76669518
29VDR_23849224_ChIP-Seq_CD4+_Human1.75137215
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74468283
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73993091
32FOXP3_21729870_ChIP-Seq_TREG_Human1.72086512
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71420897
34DCP1A_22483619_ChIP-Seq_HELA_Human1.69355172
35* GABP_19822575_ChIP-Seq_HepG2_Human1.68953016
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67214800
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64794126
38VDR_21846776_ChIP-Seq_THP-1_Human1.64294549
39* TTF2_22483619_ChIP-Seq_HELA_Human1.63083684
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61990001
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61335833
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57092282
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55495931
44* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55189589
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.54470565
46* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53698861
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53028163
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52955266
49ZNF263_19887448_ChIP-Seq_K562_Human1.49973265
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48366438
51KDM2B_26808549_Chip-Seq_DND41_Human1.48116866
52KDM5A_27292631_Chip-Seq_BREAST_Human1.46450893
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42533944
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40954388
55RACK7_27058665_Chip-Seq_MCF-7_Human1.40574999
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38417048
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34327908
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34201083
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32824553
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32406827
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31511675
62MAF_26560356_Chip-Seq_TH2_Human1.31378925
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.31350260
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31301987
65* YY1_21170310_ChIP-Seq_MESCs_Mouse1.28869899
66* P68_20966046_ChIP-Seq_HELA_Human1.28281059
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27618962
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25886874
69VDR_24763502_ChIP-Seq_THP-1_Human1.25287023
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24960776
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24657621
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23408720
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22524078
74* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19728914
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17104411
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14976183
77* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14742092
78TFEB_21752829_ChIP-Seq_HELA_Human1.14551663
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14403852
80* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13781550
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13399311
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12819965
83NCOR1_26117541_ChIP-Seq_K562_Human1.12022577
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11180024
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11140549
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10987607
87* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10712234
88* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10552200
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07518241
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07128904
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06832550
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06514812
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06130724
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05416908
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.05052945
96* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04430931
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04359242
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04033575
99* ELF1_20517297_ChIP-Seq_JURKAT_Human1.03743910
100RUNX1_22412390_ChIP-Seq_EML_Mouse1.03591106
101* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02698756
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02688751
103* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01784939
104* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01177418
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00009004
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99951173
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99689284
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99373176
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99373176
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99373176
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98070960
112* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98043427
113SMC4_20622854_ChIP-Seq_HELA_Human0.97422533
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.96755375
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96501811
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.94974679
117ELK1_19687146_ChIP-ChIP_HELA_Human0.94874389
118* TCF7_22412390_ChIP-Seq_EML_Mouse0.93407713
119UTX_26944678_Chip-Seq_JUKART_Human0.89572663
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89538425
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88977608
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87897482
123MAF_26560356_Chip-Seq_TH1_Human0.87322346
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87235095
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87151760
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86669340
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85221553
128* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85018089
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.83680431
130* ELK3_25401928_ChIP-Seq_HUVEC_Human0.82528041
131* SPI1_23547873_ChIP-Seq_NB4_Human0.82185988
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82088672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.63866862
2MP0003111_abnormal_nucleus_morphology4.28837236
3MP0010094_abnormal_chromosome_stability4.21230205
4MP0004957_abnormal_blastocyst_morpholog4.02854611
5MP0008057_abnormal_DNA_replication3.81524074
6MP0003077_abnormal_cell_cycle3.72294061
7MP0005451_abnormal_body_composition3.69084874
8MP0008058_abnormal_DNA_repair2.65924005
9MP0002396_abnormal_hematopoietic_system2.59487716
10MP0010352_gastrointestinal_tract_polyps2.58855096
11MP0008007_abnormal_cellular_replicative2.54355712
12MP0001730_embryonic_growth_arrest2.53136205
13MP0008932_abnormal_embryonic_tissue2.46432753
14MP0000350_abnormal_cell_proliferation2.38843172
15MP0010030_abnormal_orbit_morphology2.26239769
16MP0003123_paternal_imprinting2.21893628
17MP0008260_abnormal_autophagy2.16260470
18MP0004185_abnormal_adipocyte_glucose1.98139491
19MP0005380_embryogenesis_phenotype1.94655179
20MP0001672_abnormal_embryogenesis/_devel1.94655179
21MP0001697_abnormal_embryo_size1.93893602
22MP0000490_abnormal_crypts_of1.88548771
23MP0003984_embryonic_growth_retardation1.80398433
24MP0002085_abnormal_embryonic_tissue1.79080159
25MP0002088_abnormal_embryonic_growth/wei1.76906109
26MP0002084_abnormal_developmental_patter1.75650331
27MP0002080_prenatal_lethality1.74380248
28MP0005076_abnormal_cell_differentiation1.74044233
29MP0004808_abnormal_hematopoietic_stem1.67086610
30MP0010307_abnormal_tumor_latency1.65813181
31MP0002653_abnormal_ependyma_morphology1.62658775
32MP0004197_abnormal_fetal_growth/weight/1.61825946
33MP0009278_abnormal_bone_marrow1.61030389
34MP0003890_abnormal_embryonic-extraembry1.60678631
35MP0004858_abnormal_nervous_system1.60204863
36MP0002086_abnormal_extraembryonic_tissu1.58407256
37MP0008877_abnormal_DNA_methylation1.56124826
38MP0000313_abnormal_cell_death1.50214944
39MP0001293_anophthalmia1.48083436
40MP0005397_hematopoietic_system_phenotyp1.45482408
41MP0001545_abnormal_hematopoietic_system1.45482408
42MP0002019_abnormal_tumor_incidence1.43460341
43MP0003786_premature_aging1.43386422
44MP0003121_genomic_imprinting1.38852817
45MP0000703_abnormal_thymus_morphology1.35125092
46MP0003119_abnormal_digestive_system1.32292509
47MP0005501_abnormal_skin_physiology1.29910841
48MP0005058_abnormal_lysosome_morphology1.26758066
49MP0003763_abnormal_thymus_physiology1.25950014
50MP0004133_heterotaxia1.25899012
51MP0003705_abnormal_hypodermis_morpholog1.24922094
52MP0009333_abnormal_splenocyte_physiolog1.24201826
53MP0002877_abnormal_melanocyte_morpholog1.20736497
54MP0003567_abnormal_fetal_cardiomyocyte1.20554247
55MP0003436_decreased_susceptibility_to1.19922550
56MP0009053_abnormal_anal_canal1.19479593
57MP0002398_abnormal_bone_marrow1.18911462
58MP0000537_abnormal_urethra_morphology1.15217817
59MP0002796_impaired_skin_barrier1.14887366
60MP0002722_abnormal_immune_system1.13180167
61MP0000003_abnormal_adipose_tissue1.10888797
62MP0005666_abnormal_adipose_tissue1.10606104
63MP0000678_abnormal_parathyroid_gland1.09896964
64MP0004947_skin_inflammation1.09041360
65MP0002249_abnormal_larynx_morphology1.07041210
66MP0000689_abnormal_spleen_morphology1.05002297
67MP0001346_abnormal_lacrimal_gland1.04743283
68MP0008961_abnormal_basal_metabolism1.04482851
69MP0009672_abnormal_birth_weight1.04430606
70MP0006292_abnormal_olfactory_placode1.04111088
71MP0002009_preneoplasia1.03227522
72MP0001849_ear_inflammation1.00329448
73MP0002111_abnormal_tail_morphology0.97431459
74MP0003453_abnormal_keratinocyte_physiol0.97238620
75MP0005023_abnormal_wound_healing0.96349879
76MP0004264_abnormal_extraembryonic_tissu0.95455832
77MP0005375_adipose_tissue_phenotype0.95274425
78MP0006035_abnormal_mitochondrial_morpho0.95170981
79MP0000428_abnormal_craniofacial_morphol0.91783539
80MP0002210_abnormal_sex_determination0.91436481
81MP0006054_spinal_hemorrhage0.90521714
82MP0002429_abnormal_blood_cell0.89874063
83MP0001145_abnormal_male_reproductive0.89529108
84MP0001915_intracranial_hemorrhage0.89003364
85MP0000358_abnormal_cell_content/0.88958312
86MP0002970_abnormal_white_adipose0.87735942
87MP0001873_stomach_inflammation0.87215094
88MP0002092_abnormal_eye_morphology0.86788276
89MP0000858_altered_metastatic_potential0.86244649
90MP0003315_abnormal_perineum_morphology0.85714506
91MP0005384_cellular_phenotype0.84070543
92MP0003303_peritoneal_inflammation0.83061897
93MP0005310_abnormal_salivary_gland0.81865601
94MP0000477_abnormal_intestine_morphology0.81567119
95MP0002420_abnormal_adaptive_immunity0.81119167
96MP0009703_decreased_birth_body0.80831453
97MP0001819_abnormal_immune_cell0.80429960
98MP0005621_abnormal_cell_physiology0.79168993
99MP0009931_abnormal_skin_appearance0.78205720
100MP0001835_abnormal_antigen_presentation0.77474987
101MP0003566_abnormal_cell_adhesion0.76014897
102MP0000685_abnormal_immune_system0.75713638
103MP0003806_abnormal_nucleotide_metabolis0.74848762
104MP0000716_abnormal_immune_system0.74781237
105MP0003283_abnormal_digestive_organ0.74398903
106MP0001348_abnormal_lacrimal_gland0.74348948
107MP0003115_abnormal_respiratory_system0.73995517
108MP0003718_maternal_effect0.73602071
109MP0001853_heart_inflammation0.73292080
110MP0003866_abnormal_defecation0.73246449
111MP0001929_abnormal_gametogenesis0.71133625
112MP0005083_abnormal_biliary_tract0.70440130
113MP0002925_abnormal_cardiovascular_devel0.70223624
114MP0004233_abnormal_muscle_weight0.69670143
115MP0008770_decreased_survivor_rate0.67972130
116MP0005000_abnormal_immune_tolerance0.67868772
117MP0000653_abnormal_sex_gland0.67333458
118MP0010630_abnormal_cardiac_muscle0.67148497
119MP0000681_abnormal_thyroid_gland0.67104532
120MP0002089_abnormal_postnatal_growth/wei0.66830422
121MP0001286_abnormal_eye_development0.66572926
122MP0000049_abnormal_middle_ear0.66365618
123MP0002452_abnormal_antigen_presenting0.66321981
124MP0003935_abnormal_craniofacial_develop0.65953680
125MP0002932_abnormal_joint_morphology0.65782633
126MP0003861_abnormal_nervous_system0.64280714
127MP0003221_abnormal_cardiomyocyte_apopto0.62988415
128MP0002075_abnormal_coat/hair_pigmentati0.62858214
129MP0005464_abnormal_platelet_physiology0.62730657
130MP0005075_abnormal_melanosome_morpholog0.61715069
131MP0002160_abnormal_reproductive_system0.61572658
132MP0002405_respiratory_system_inflammati0.58561340
133MP0003937_abnormal_limbs/digits/tail_de0.58410535
134MP0001800_abnormal_humoral_immune0.57890653
135MP0000733_abnormal_muscle_development0.57804182
136MP0000432_abnormal_head_morphology0.57515632
137MP0002132_abnormal_respiratory_system0.57190407

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.02882774
2Birth length less than 3rd percentile (HP:0003561)3.80070143
3Ependymoma (HP:0002888)3.78169516
4Progressive muscle weakness (HP:0003323)3.77922919
5Reticulocytopenia (HP:0001896)3.62332257
6Selective tooth agenesis (HP:0001592)3.55939748
7Medulloblastoma (HP:0002885)3.26139140
8Patellar aplasia (HP:0006443)3.24690712
9Abnormality of cells of the erythroid lineage (HP:0012130)3.15343353
10Ragged-red muscle fibers (HP:0003200)3.09719218
11Chromsome breakage (HP:0040012)3.09463678
12Breast hypoplasia (HP:0003187)3.07578270
13Abnormal number of incisors (HP:0011064)3.03938822
14Abnormal number of erythroid precursors (HP:0012131)3.03030185
15Abnormality of the anterior horn cell (HP:0006802)3.02920550
16Degeneration of anterior horn cells (HP:0002398)3.02920550
17Aplasia/Hypoplasia of the patella (HP:0006498)3.02499658
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93928245
19Oral leukoplakia (HP:0002745)2.92645198
20Increased nuchal translucency (HP:0010880)2.92154929
21Broad distal phalanx of finger (HP:0009836)2.89544573
22Long palpebral fissure (HP:0000637)2.88671308
23Colon cancer (HP:0003003)2.84524375
24Abnormality of the fingertips (HP:0001211)2.80097279
25Basal cell carcinoma (HP:0002671)2.74623243
26Urethral obstruction (HP:0000796)2.70428259
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.67359123
28Cellulitis (HP:0100658)2.61018696
29Agnosia (HP:0010524)2.60688211
30Abnormality of the ileum (HP:0001549)2.58132462
31Proximal placement of thumb (HP:0009623)2.57745567
32Rhabdomyosarcoma (HP:0002859)2.57195594
33Meckel diverticulum (HP:0002245)2.57136962
34Absent radius (HP:0003974)2.55722231
35Broad face (HP:0000283)2.52718134
36Absent thumb (HP:0009777)2.47546368
37Abnormality of the columella (HP:0009929)2.46520891
38Short 4th metacarpal (HP:0010044)2.46321500
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46321500
40Trismus (HP:0000211)2.46195369
41Deviation of the thumb (HP:0009603)2.45769849
42Atresia of the external auditory canal (HP:0000413)2.44580691
43Neoplasm of the pancreas (HP:0002894)2.43796160
44Aplastic anemia (HP:0001915)2.43601684
45Colitis (HP:0002583)2.42763916
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42580618
47Reticulocytosis (HP:0001923)2.42452985
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.41426927
49Neoplasm of striated muscle (HP:0009728)2.40636903
50Myelodysplasia (HP:0002863)2.38514902
51Absent forearm bone (HP:0003953)2.38301591
52Aplasia involving forearm bones (HP:0009822)2.38301591
53Progressive external ophthalmoplegia (HP:0000590)2.35012432
54Astrocytoma (HP:0009592)2.34247967
55Abnormality of the astrocytes (HP:0100707)2.34247967
56Abnormality of the preputium (HP:0100587)2.33838028
57Rough bone trabeculation (HP:0100670)2.33525488
58Abnormality of chromosome stability (HP:0003220)2.33324678
59Carpal bone hypoplasia (HP:0001498)2.32660315
60Insomnia (HP:0100785)2.31286737
61Renal duplication (HP:0000075)2.31016332
62Ulnar bowing (HP:0003031)2.30584278
63Neoplasm of the oral cavity (HP:0100649)2.27520473
64Agammaglobulinemia (HP:0004432)2.27165902
65Trigonocephaly (HP:0000243)2.25286663
66Pallor (HP:0000980)2.23732913
67Hyperacusis (HP:0010780)2.23496647
68Achilles tendon contracture (HP:0001771)2.23434806
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.22677320
70Cholecystitis (HP:0001082)2.22512393
71Abnormal gallbladder physiology (HP:0012438)2.22512393
72Small intestinal stenosis (HP:0012848)2.20120744
73Duodenal stenosis (HP:0100867)2.20120744
74Tracheoesophageal fistula (HP:0002575)2.17991825
75Recurrent viral infections (HP:0004429)2.16925396
76Microretrognathia (HP:0000308)2.16718336
77Skin tags (HP:0010609)2.16038190
78Pointed chin (HP:0000307)2.14542895
79Aplasia/Hypoplasia of the thymus (HP:0010515)2.13992504
80Distal lower limb amyotrophy (HP:0008944)2.13410427
81Preauricular skin tag (HP:0000384)2.13144465
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.13104102
83Prominent nose (HP:0000448)2.12434784
84Macrocytic anemia (HP:0001972)2.12134948
85Panhypogammaglobulinemia (HP:0003139)2.10877977
86Multiple enchondromatosis (HP:0005701)2.10182655
87Overlapping toe (HP:0001845)2.09835321
88Slow saccadic eye movements (HP:0000514)2.09295617
89Self-mutilation (HP:0000742)2.09194577
90Hypertensive crisis (HP:0100735)2.08763256
91Impulsivity (HP:0100710)2.07972629
92Abnormal lung lobation (HP:0002101)2.07916373
93Thrombocytosis (HP:0001894)2.07853177
94Abnormality of the carotid arteries (HP:0005344)2.05880927
95Abnormality of the labia minora (HP:0012880)2.05667342
96Ectopic kidney (HP:0000086)2.04942311
97Testicular atrophy (HP:0000029)2.04392572
98Abnormality of abdominal situs (HP:0011620)2.03462348
99Abdominal situs inversus (HP:0003363)2.03462348
100Glioma (HP:0009733)2.02902753
10111 pairs of ribs (HP:0000878)2.02449696
102Facial hemangioma (HP:0000329)2.01918669
103Septate vagina (HP:0001153)2.01455820
104Supernumerary spleens (HP:0009799)2.01201978
105Rib fusion (HP:0000902)1.99899631
106Bone marrow hypocellularity (HP:0005528)1.98054149
107Increased neuronal autofluorescent lipopigment (HP:0002074)1.97648289
108Poikiloderma (HP:0001029)1.97453220
109Cafe-au-lait spot (HP:0000957)1.97318086
110Premature graying of hair (HP:0002216)1.97010894
111Missing ribs (HP:0000921)1.96500892
112High pitched voice (HP:0001620)1.96286814
113Increased cerebral lipofuscin (HP:0011813)1.95903080
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.95790825
115Pseudobulbar signs (HP:0002200)1.95283320
116Amaurosis fugax (HP:0100576)1.95052144
117High anterior hairline (HP:0009890)1.94460040
118Overriding aorta (HP:0002623)1.94018480
119Acute lymphatic leukemia (HP:0006721)1.93700728
120Dysmetric saccades (HP:0000641)1.93131995
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92236353
122Squamous cell carcinoma (HP:0002860)1.91803330
123Sparse lateral eyebrow (HP:0005338)1.91788539
124Abnormality of the duodenum (HP:0002246)1.90135477
125Cellular immunodeficiency (HP:0005374)1.89660853
126Cerebral hypomyelination (HP:0006808)1.89324754
127Long eyelashes (HP:0000527)1.88666175
128Seborrheic dermatitis (HP:0001051)1.88103285
129Premature ovarian failure (HP:0008209)1.87438853
130Gastrointestinal inflammation (HP:0004386)1.87095537
131Triphalangeal thumb (HP:0001199)1.86432431
132Slender long bone (HP:0003100)1.86237337
133Abnormality of reticulocytes (HP:0004312)1.85881668
134Malignant gastrointestinal tract tumors (HP:0006749)1.84729315
135Gastrointestinal carcinoma (HP:0002672)1.84729315
136Sloping forehead (HP:0000340)1.84647727
137Abnormality of the Achilles tendon (HP:0005109)1.84324104
138Myopathic facies (HP:0002058)1.84222565
139Volvulus (HP:0002580)1.83981548
140Abnormality of the thoracic spine (HP:0100711)1.83412003
141Deep palmar crease (HP:0006191)1.80973090
142Entropion (HP:0000621)1.80678262
143Patellar dislocation (HP:0002999)1.80283694
144Angiofibromas (HP:0010615)1.79830026
145Adenoma sebaceum (HP:0009720)1.79830026
146Gastrointestinal dysmotility (HP:0002579)1.79014398
147Flared metaphyses (HP:0003015)1.78483092
148Disproportionate tall stature (HP:0001519)1.77582028
149Aplasia/hypoplasia of the humerus (HP:0006507)1.77193846
150Short thumb (HP:0009778)1.74939424
151Horseshoe kidney (HP:0000085)1.73364627
152Spinal muscular atrophy (HP:0007269)1.72921854
153Syringomyelia (HP:0003396)1.72705607
154Spinal cord lesions (HP:0100561)1.72705607
155Metaphyseal cupping (HP:0003021)1.72551791
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72075354
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71347752
158Truncus arteriosus (HP:0001660)1.68198926
159Neuronal loss in central nervous system (HP:0002529)1.66526948
160Viral hepatitis (HP:0006562)1.65947883
161Hypoplasia of the thymus (HP:0000778)1.64527151
162Bowel incontinence (HP:0002607)1.63493297
163Persistence of primary teeth (HP:0006335)1.63060583
164Abnormal large intestine physiology (HP:0012700)1.62366430
165Abnormal trabecular bone morphology (HP:0100671)1.62209898
166Duplication of thumb phalanx (HP:0009942)1.56899643
167Hypergonadotropic hypogonadism (HP:0000815)1.56009761
168Abnormality of the calcaneus (HP:0008364)1.55804637
169Abnormality of the phalanges of the hallux (HP:0010057)1.55595832
170Dislocated radial head (HP:0003083)1.55229895
171Combined immunodeficiency (HP:0005387)1.54581220
172Spastic diplegia (HP:0001264)1.54454387
173Spina bifida occulta (HP:0003298)1.53370841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.54427837
2SMG14.34856917
3CDC73.93935346
4WEE13.31672591
5CDK123.17188238
6EEF2K3.01922685
7NEK22.85060389
8PRPF4B2.77975722
9MAP3K102.66065634
10VRK22.62696632
11PASK2.38212878
12TTK2.20064154
13TESK22.18381783
14EIF2AK12.07364823
15PKN21.93361043
16CDK71.91269880
17TSSK61.85157396
18PLK11.81020458
19STK101.77794703
20RPS6KB21.77097896
21NEK11.75598568
22SIK11.74107537
23DYRK31.73012202
24MAP4K11.70949741
25TLK11.67355153
26RPS6KA41.65571869
27ATR1.62616732
28IRAK31.61329320
29CDK41.58161031
30SRPK11.55625850
31TRIB31.55602354
32MAP3K81.48239065
33PAK41.46965350
34* AURKB1.38815096
35BRD41.38047040
36TAOK21.37582755
37FLT31.27939823
38CHEK21.23401847
39MKNK11.21697369
40ACVR1B1.21441691
41EIF2AK31.21122256
42SCYL21.17814424
43* CHEK11.17089581
44NME21.16837282
45BRSK21.15108172
46GRK61.14185351
47AURKA1.13780573
48EPHA21.13436033
49VRK11.08171787
50ERN11.06670987
51STK41.04367998
52ALK1.01599169
53EPHB11.00946040
54PLK40.97851796
55FGFR40.97655562
56TGFBR10.96578590
57BRSK10.94252415
58ARAF0.91777430
59PBK0.91741172
60LRRK20.91340783
61PLK30.90347299
62* CDK20.89713719
63MKNK20.89062944
64MAP3K110.88336479
65MTOR0.87271981
66TAF10.85762996
67MARK20.84299629
68PIM10.81123252
69ATM0.78603960
70RAF10.78296946
71TTN0.77664623
72PAK10.76130859
73MAPKAPK30.76014824
74ICK0.75608121
75CAMK1D0.74726609
76CDK60.71754629
77MAP2K20.71207258
78MELK0.70139963
79MAP3K130.70094813
80SIK20.69651509
81BTK0.67947853
82CSF1R0.66558464
83NME10.66519660
84BMX0.62832095
85CDK80.62831402
86KSR20.61227658
87MAP3K10.60567051
88PIM20.60398619
89CDK10.60333489
90PRKD20.59837680
91MAP2K30.59779796
92TESK10.58254286
93STK160.56384107
94CSNK2A20.55493582
95ZAP700.53914732
96KDR0.53566896
97AKT20.51773983
98PRKCI0.51097395
99IRAK40.48695119
100JAK30.48418498
101CCNB10.48026260
102FGFR10.46232507
103RPS6KA20.45882046
104CLK10.45071391
105CSNK2A10.45065045
106DAPK10.44898095
107LATS20.44008949
108STK30.42272777
109MAP3K140.41860585
110PTK60.41645791
111TBK10.40667338
112PAK20.40556352
113RPS6KA60.37218131
114MAPK110.35805475
115CSNK1E0.34857868
116IRAK20.34019239
117CDC42BPA0.33294217
118RPS6KA10.32534567
119MAPKAPK20.32268505
120MATK0.32104137
121PRKDC0.31898001
122BCKDK0.31854580
123CDK11A0.31472437
124DYRK1B0.30211027
125BRAF0.29790645
126RPS6KA50.29500584
127CHUK0.29221534
128RPS6KC10.28613042
129RPS6KL10.28613042
130CDK90.27593786
131TAOK10.27543466
132HIPK20.26400706

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.12994708
2Mismatch repair_Homo sapiens_hsa034304.38797616
3Spliceosome_Homo sapiens_hsa030403.45863495
4Base excision repair_Homo sapiens_hsa034103.29590636
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22781949
6RNA transport_Homo sapiens_hsa030133.09513274
7Ribosome_Homo sapiens_hsa030102.91297224
8Cell cycle_Homo sapiens_hsa041102.85664016
9One carbon pool by folate_Homo sapiens_hsa006702.80189160
10Homologous recombination_Homo sapiens_hsa034402.79628141
11Nucleotide excision repair_Homo sapiens_hsa034202.60794674
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49358663
13RNA polymerase_Homo sapiens_hsa030202.40407195
14Pyrimidine metabolism_Homo sapiens_hsa002402.07902166
15mRNA surveillance pathway_Homo sapiens_hsa030152.06842420
16Proteasome_Homo sapiens_hsa030502.00846512
17Fanconi anemia pathway_Homo sapiens_hsa034601.98068280
18Non-homologous end-joining_Homo sapiens_hsa034501.86553326
19RNA degradation_Homo sapiens_hsa030181.68455801
20p53 signaling pathway_Homo sapiens_hsa041151.61841316
21Basal transcription factors_Homo sapiens_hsa030221.43489237
22Epstein-Barr virus infection_Homo sapiens_hsa051691.19149578
23Viral carcinogenesis_Homo sapiens_hsa052031.12154496
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11736604
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05999625
26Selenocompound metabolism_Homo sapiens_hsa004501.05654278
27Herpes simplex infection_Homo sapiens_hsa051681.05491188
28Notch signaling pathway_Homo sapiens_hsa043301.03468769
29Biosynthesis of amino acids_Homo sapiens_hsa012301.02406145
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02353919
31HTLV-I infection_Homo sapiens_hsa051661.00915547
32Oocyte meiosis_Homo sapiens_hsa041140.99550236
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.97634699
34Pentose phosphate pathway_Homo sapiens_hsa000300.96973162
35Systemic lupus erythematosus_Homo sapiens_hsa053220.93707629
36Antigen processing and presentation_Homo sapiens_hsa046120.93093019
37Purine metabolism_Homo sapiens_hsa002300.92263120
38MicroRNAs in cancer_Homo sapiens_hsa052060.92222875
39Basal cell carcinoma_Homo sapiens_hsa052170.89128216
40Chronic myeloid leukemia_Homo sapiens_hsa052200.84908797
41Thyroid cancer_Homo sapiens_hsa052160.84367590
42Other glycan degradation_Homo sapiens_hsa005110.79509973
43Small cell lung cancer_Homo sapiens_hsa052220.77767852
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.77612941
45Primary immunodeficiency_Homo sapiens_hsa053400.71964279
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.71776084
47Bladder cancer_Homo sapiens_hsa052190.71127656
48Folate biosynthesis_Homo sapiens_hsa007900.69983721
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69735345
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69223166
51Colorectal cancer_Homo sapiens_hsa052100.69131735
52Acute myeloid leukemia_Homo sapiens_hsa052210.68857363
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68621703
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65961846
55Sulfur relay system_Homo sapiens_hsa041220.65588449
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63212277
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62887725
58Legionellosis_Homo sapiens_hsa051340.62456519
59Hippo signaling pathway_Homo sapiens_hsa043900.61739877
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61539051
61Apoptosis_Homo sapiens_hsa042100.61132338
62Shigellosis_Homo sapiens_hsa051310.60794077
63Lysine degradation_Homo sapiens_hsa003100.60307237
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.59799727
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59316681
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57960885
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57602478
68Hedgehog signaling pathway_Homo sapiens_hsa043400.56475208
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55595697
70Hepatitis C_Homo sapiens_hsa051600.55429446
71mTOR signaling pathway_Homo sapiens_hsa041500.55240712
72N-Glycan biosynthesis_Homo sapiens_hsa005100.55151574
73ErbB signaling pathway_Homo sapiens_hsa040120.55029428
74Hepatitis B_Homo sapiens_hsa051610.54742568
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54715935
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54207974
77Glioma_Homo sapiens_hsa052140.54005850
78Prion diseases_Homo sapiens_hsa050200.53295011
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51334274
80AMPK signaling pathway_Homo sapiens_hsa041520.50954629
81Insulin signaling pathway_Homo sapiens_hsa049100.48408947
82Measles_Homo sapiens_hsa051620.46309975
83Fructose and mannose metabolism_Homo sapiens_hsa000510.46261436
84Carbon metabolism_Homo sapiens_hsa012000.46173129
85Renal cell carcinoma_Homo sapiens_hsa052110.45287820
86Non-small cell lung cancer_Homo sapiens_hsa052230.45229474
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44218537
88Pathways in cancer_Homo sapiens_hsa052000.42538945
89B cell receptor signaling pathway_Homo sapiens_hsa046620.42108681
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41981119
91Inositol phosphate metabolism_Homo sapiens_hsa005620.41485906
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40961998
93Galactose metabolism_Homo sapiens_hsa000520.40905341
94HIF-1 signaling pathway_Homo sapiens_hsa040660.39999644
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39216266
96Adherens junction_Homo sapiens_hsa045200.38895063
97Pancreatic cancer_Homo sapiens_hsa052120.37554083
98Viral myocarditis_Homo sapiens_hsa054160.37395057
99TGF-beta signaling pathway_Homo sapiens_hsa043500.37084590
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.35603523
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34944841
102Salmonella infection_Homo sapiens_hsa051320.34866358
103Influenza A_Homo sapiens_hsa051640.32959942
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32916205
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32896745
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32252951
107Alcoholism_Homo sapiens_hsa050340.29137910
108Endometrial cancer_Homo sapiens_hsa052130.27734577
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.26829612
110Prostate cancer_Homo sapiens_hsa052150.26720042
111Wnt signaling pathway_Homo sapiens_hsa043100.24326371
112Proteoglycans in cancer_Homo sapiens_hsa052050.24256846
113T cell receptor signaling pathway_Homo sapiens_hsa046600.23840495
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.21534867
115Vitamin B6 metabolism_Homo sapiens_hsa007500.21256834
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20515438
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.16865936
118VEGF signaling pathway_Homo sapiens_hsa043700.16163760
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15889628
120Leishmaniasis_Homo sapiens_hsa051400.15052298

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