RBM15B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.54391928
2regulation of chromatin binding (GO:0035561)4.26260988
3DNA unwinding involved in DNA replication (GO:0006268)4.20407163
4dosage compensation (GO:0007549)3.97686358
5regulation of NFAT protein import into nucleus (GO:0051532)3.77045394
6regulation of mammary gland epithelial cell proliferation (GO:0033599)3.74376179
7protein localization to kinetochore (GO:0034501)3.67132109
8negative regulation of histone methylation (GO:0031061)3.66209513
9regulation of RNA export from nucleus (GO:0046831)3.64705907
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50605622
11heterochromatin organization (GO:0070828)3.47908089
12chromatin assembly (GO:0031497)3.47710899
13nuclear pore complex assembly (GO:0051292)3.46584506
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43721686
15regulation of sister chromatid cohesion (GO:0007063)3.42832136
16convergent extension (GO:0060026)3.39497203
17regulation of hippo signaling (GO:0035330)3.38818814
18apoptotic process involved in morphogenesis (GO:0060561)3.38804582
19nucleosome disassembly (GO:0006337)3.38436644
20protein-DNA complex disassembly (GO:0032986)3.38436644
21adherens junction assembly (GO:0034333)3.37837907
22regulation of histone H3-K9 methylation (GO:0051570)3.35996441
23negative regulation of RNA splicing (GO:0033119)3.35334459
24RNA stabilization (GO:0043489)3.33251605
25mRNA stabilization (GO:0048255)3.33251605
26peptidyl-lysine dimethylation (GO:0018027)3.32487099
27cytoplasmic mRNA processing body assembly (GO:0033962)3.30416663
28protein complex localization (GO:0031503)3.28187433
29cellular protein complex localization (GO:0034629)3.23436121
30negative regulation of erythrocyte differentiation (GO:0045647)3.22730261
31nuclear pore organization (GO:0006999)3.22300341
32protein localization to chromosome, centromeric region (GO:0071459)3.20966011
33mitotic chromosome condensation (GO:0007076)3.16361039
34regulation of translational fidelity (GO:0006450)3.13145424
35sister chromatid segregation (GO:0000819)3.12298577
36ribosomal small subunit biogenesis (GO:0042274)3.11844064
37Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.11456397
38glucocorticoid receptor signaling pathway (GO:0042921)3.10951269
39epithelial cell differentiation involved in prostate gland development (GO:0060742)3.09180709
40mitotic sister chromatid cohesion (GO:0007064)3.06735840
41cell-substrate adherens junction assembly (GO:0007045)3.04065180
42focal adhesion assembly (GO:0048041)3.04065180
43DNA duplex unwinding (GO:0032508)3.03064794
44peptidyl-arginine methylation (GO:0018216)2.99130198
45peptidyl-arginine N-methylation (GO:0035246)2.99130198
46DNA geometric change (GO:0032392)2.97967533
47negative regulation of mRNA processing (GO:0050686)2.97050228
48DNA replication-dependent nucleosome organization (GO:0034723)2.94530665
49DNA replication-dependent nucleosome assembly (GO:0006335)2.94530665
50polarized epithelial cell differentiation (GO:0030859)2.94373660
51hippo signaling (GO:0035329)2.92797655
52regulation of establishment of planar polarity (GO:0090175)2.92514596
53peptidyl-arginine omega-N-methylation (GO:0035247)2.91040393
54regulation of glucose import in response to insulin stimulus (GO:2001273)2.86578365
55planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85140790
56intracellular estrogen receptor signaling pathway (GO:0030520)2.84893298
57regulation of mRNA stability (GO:0043488)2.84148218
58histone H2A monoubiquitination (GO:0035518)2.83303935
59alternative mRNA splicing, via spliceosome (GO:0000380)2.81741767
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81640454
61mitotic nuclear envelope disassembly (GO:0007077)2.80180790
62positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.79784520
63negative regulation of mRNA metabolic process (GO:1903312)2.79116541
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77216052
65protein localization to endosome (GO:0036010)2.76965036
66membrane disassembly (GO:0030397)2.76820628
67nuclear envelope disassembly (GO:0051081)2.76820628
68glial cell proliferation (GO:0014009)2.76372198
69regulation of nucleobase-containing compound transport (GO:0032239)2.75743220
70paraxial mesoderm development (GO:0048339)2.74028512
71regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.73987479
72embryonic eye morphogenesis (GO:0048048)2.71201473
73cell-substrate junction assembly (GO:0007044)2.69595040
74basement membrane organization (GO:0071711)2.69589118
75regulation of gene silencing by RNA (GO:0060966)2.69515262
76regulation of posttranscriptional gene silencing (GO:0060147)2.69515262
77regulation of gene silencing by miRNA (GO:0060964)2.69515262
78chromatin assembly or disassembly (GO:0006333)2.69111719
79regulation of DNA damage checkpoint (GO:2000001)2.68707778
80semaphorin-plexin signaling pathway (GO:0071526)2.67995024
81establishment of apical/basal cell polarity (GO:0035089)2.67944761
82gastrulation with mouth forming second (GO:0001702)2.67934088
83embryonic process involved in female pregnancy (GO:0060136)2.67713307
84positive regulation of SMAD protein import into nucleus (GO:0060391)2.67038508
85DNA topological change (GO:0006265)2.66457544
86eye morphogenesis (GO:0048592)2.65047392
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.64871017
88positive regulation of histone deacetylation (GO:0031065)2.64048802
89folic acid-containing compound biosynthetic process (GO:0009396)2.63482241
90cochlea morphogenesis (GO:0090103)2.62828267
91regulation of RNA stability (GO:0043487)2.62042571
92protein localization to chromosome (GO:0034502)2.61603938
93embryonic foregut morphogenesis (GO:0048617)2.61570733
94atrioventricular valve morphogenesis (GO:0003181)2.61219461
95embryonic camera-type eye morphogenesis (GO:0048596)2.60487071
96histone H3-K36 demethylation (GO:0070544)2.60352074
97corticosteroid receptor signaling pathway (GO:0031958)2.59700215
98negative regulation of cell fate specification (GO:0009996)2.57006181
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.56944204
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.56944204
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56944204
102lymph vessel development (GO:0001945)2.56833061
103spliceosomal tri-snRNP complex assembly (GO:0000244)2.56536999
104regulation of early endosome to late endosome transport (GO:2000641)2.55202622
105maturation of SSU-rRNA (GO:0030490)2.54793020
106ectodermal placode formation (GO:0060788)2.54740360
107positive regulation of chromosome segregation (GO:0051984)2.53894560
108gene silencing by RNA (GO:0031047)2.53541599
109cellular response to epidermal growth factor stimulus (GO:0071364)2.53210260
110mitotic sister chromatid segregation (GO:0000070)2.53007950
111protein localization to microtubule (GO:0035372)2.52994146
112regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.51924564
113response to laminar fluid shear stress (GO:0034616)2.50931536
114non-canonical Wnt signaling pathway (GO:0035567)2.50244778
115establishment of monopolar cell polarity (GO:0061162)2.49883051
116establishment or maintenance of monopolar cell polarity (GO:0061339)2.49883051
117pore complex assembly (GO:0046931)2.48358193
118formation of translation preinitiation complex (GO:0001731)2.48094897
119dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47878037
120maternal placenta development (GO:0001893)2.46925085
121dorsal/ventral axis specification (GO:0009950)2.46893788
122trophoblast giant cell differentiation (GO:0060707)2.46444857
123gene silencing (GO:0016458)2.46311481
124trophectodermal cell differentiation (GO:0001829)2.46009948
125activation of Rac GTPase activity (GO:0032863)2.45557110
126regulation of SMAD protein import into nucleus (GO:0060390)2.45094466
127negative regulation of histone modification (GO:0031057)2.44532269
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44439040
129translesion synthesis (GO:0019985)2.44234862
130protein retention in ER lumen (GO:0006621)2.43576718
131ATP-dependent chromatin remodeling (GO:0043044)2.43260926
1323-UTR-mediated mRNA stabilization (GO:0070935)2.42896555
133viral transcription (GO:0019083)2.42480650
134NLS-bearing protein import into nucleus (GO:0006607)2.41687938
135positive regulation of RNA splicing (GO:0033120)2.41176063
136apoptotic process involved in development (GO:1902742)2.40794689
137stress fiber assembly (GO:0043149)2.39409998
138negative regulation of gene expression, epigenetic (GO:0045814)2.39332473
139chromosome condensation (GO:0030261)2.37825901
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.36068639
141nuclear envelope organization (GO:0006998)2.35936135
142proline biosynthetic process (GO:0006561)2.35509996
143pinocytosis (GO:0006907)2.35185520
144nucleosome organization (GO:0034728)2.35048590
145negative regulation of fatty acid transport (GO:2000192)2.34550954
146regulation of protein heterodimerization activity (GO:0043497)2.34197424
147nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.34114454
148neural tube development (GO:0021915)2.33474596
149DNA conformation change (GO:0071103)2.33401825
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.32891582
151epithelial cell-cell adhesion (GO:0090136)2.32630566
152negative regulation of DNA repair (GO:0045738)2.32366467
153body morphogenesis (GO:0010171)2.32305566
154modulation by symbiont of host cellular process (GO:0044068)2.30560012
155modulation by virus of host process (GO:0019054)2.28815158
156establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.28193816
157negative regulation of cell size (GO:0045792)2.27099488
158histone arginine methylation (GO:0034969)2.26125230
159rRNA transcription (GO:0009303)2.25695171
160hemidesmosome assembly (GO:0031581)2.24090357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67834161
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.22759898
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.17971418
4MYC_22102868_ChIP-Seq_BL_Human3.71959136
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.69230999
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08233853
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90186253
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89895026
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45102642
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.43693699
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22520834
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.21472121
13TCF7_22412390_ChIP-Seq_EML_Mouse2.18981994
14KDM2B_26808549_Chip-Seq_DND41_Human2.15184635
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10204813
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09620290
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09108191
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04389268
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03179312
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00638001
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99961419
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99349760
23VDR_21846776_ChIP-Seq_THP-1_Human1.96027295
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.95465177
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.95025682
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91724082
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89895675
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86662441
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82568583
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76477801
31* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.76450794
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74608049
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.69019570
34CIITA_25753668_ChIP-Seq_RAJI_Human1.65585575
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63998351
36ZNF263_19887448_ChIP-Seq_K562_Human1.63515663
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63330880
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62382480
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59422802
40PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58357678
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.57983566
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56655275
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53932009
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52539725
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52038216
46KDM2B_26808549_Chip-Seq_K562_Human1.50996184
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.48123481
48* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47913441
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47287667
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46282914
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46054332
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45686028
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.43853194
54VDR_24763502_ChIP-Seq_THP-1_Human1.42516607
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40643467
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.39785128
57XRN2_22483619_ChIP-Seq_HELA_Human1.39387844
58UTX_26944678_Chip-Seq_JUKART_Human1.38719364
59CHD1_26751641_Chip-Seq_LNCaP_Human1.38274128
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38273780
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36244672
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35933197
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33811600
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31951318
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31602569
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31392274
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28119517
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28119517
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28119517
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27924622
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27206694
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24342010
73ATF3_27146783_Chip-Seq_COLON_Human1.23785313
74AR_21909140_ChIP-Seq_LNCAP_Human1.23319201
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22587978
76MAF_26560356_Chip-Seq_TH1_Human1.20875928
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20678478
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20561457
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20194453
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.20154549
81KDM5A_27292631_Chip-Seq_BREAST_Human1.20137729
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.20126171
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.19758072
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19547500
85CREB1_26743006_Chip-Seq_LNCaP_Human1.19479863
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17764594
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17584026
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15418031
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14718837
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14205583
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14127056
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14071218
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13416450
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13392601
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12259657
96RACK7_27058665_Chip-Seq_MCF-7_Human1.11754273
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09784478
98MAF_26560356_Chip-Seq_TH2_Human1.09733016
99NCOR1_26117541_ChIP-Seq_K562_Human1.08974524
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08881935
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08810819
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07302564
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07129325
104TP53_22127205_ChIP-Seq_IMR90_Human1.04540517
105P68_20966046_ChIP-Seq_HELA_Human1.04129035
106* LXR_22292898_ChIP-Seq_THP-1_Human1.03456958
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02933152
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01886603
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.00712195
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00290497
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99827222
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99334021
113CLOCK_20551151_ChIP-Seq_293T_Human0.98621542
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97457425
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97245359
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96775922
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96363835
118TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95737083
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95288198
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94782239
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94310752
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.93825456
123TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93534044
124TTF2_22483619_ChIP-Seq_HELA_Human0.92988761
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.91950923
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.91697584
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91001239
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.90947813
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90133365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.27420389
2MP0010352_gastrointestinal_tract_polyps3.22253857
3MP0000537_abnormal_urethra_morphology2.99288888
4MP0005076_abnormal_cell_differentiation2.75306379
5MP0010030_abnormal_orbit_morphology2.32457790
6MP0003123_paternal_imprinting2.31385377
7MP0004858_abnormal_nervous_system2.26441255
8MP0009053_abnormal_anal_canal2.19575545
9MP0010234_abnormal_vibrissa_follicle2.17742393
10MP0003111_abnormal_nucleus_morphology2.12832409
11MP0010094_abnormal_chromosome_stability1.99751023
12MP0003693_abnormal_embryo_hatching1.95801690
13MP0003077_abnormal_cell_cycle1.95070627
14MP0003121_genomic_imprinting1.92800801
15MP0004957_abnormal_blastocyst_morpholog1.88022259
16MP0008438_abnormal_cutaneous_collagen1.87382958
17MP0008789_abnormal_olfactory_epithelium1.86455046
18MP0002877_abnormal_melanocyte_morpholog1.85544873
19MP0004197_abnormal_fetal_growth/weight/1.82790019
20MP0002084_abnormal_developmental_patter1.80539076
21MP0001849_ear_inflammation1.80427581
22MP0005409_darkened_coat_color1.79042959
23MP0003787_abnormal_imprinting1.75109252
24MP0002796_impaired_skin_barrier1.74795641
25MP0000350_abnormal_cell_proliferation1.74689811
26MP0003453_abnormal_keratinocyte_physiol1.73412359
27MP0000569_abnormal_digit_pigmentation1.73319493
28MP0005394_taste/olfaction_phenotype1.72624108
29MP0005499_abnormal_olfactory_system1.72624108
30MP0002009_preneoplasia1.71625432
31MP0003890_abnormal_embryonic-extraembry1.70849085
32MP0003119_abnormal_digestive_system1.68977219
33MP0002085_abnormal_embryonic_tissue1.68259469
34MP0005623_abnormal_meninges_morphology1.67528198
35MP0001730_embryonic_growth_arrest1.63185715
36MP0003300_gastrointestinal_ulcer1.59182778
37MP0000566_synostosis1.58165467
38MP0000428_abnormal_craniofacial_morphol1.57396216
39MP0004272_abnormal_basement_membrane1.57308230
40MP0005380_embryogenesis_phenotype1.55668366
41MP0001672_abnormal_embryogenesis/_devel1.55668366
42MP0003385_abnormal_body_wall1.53966337
43MP0000733_abnormal_muscle_development1.52510578
44MP0003115_abnormal_respiratory_system1.52078866
45MP0001293_anophthalmia1.51504223
46MP0005451_abnormal_body_composition1.50587972
47MP0008007_abnormal_cellular_replicative1.49394251
48MP0009278_abnormal_bone_marrow1.48322319
49MP0002088_abnormal_embryonic_growth/wei1.46138343
50MP0003984_embryonic_growth_retardation1.45218525
51MP0001697_abnormal_embryo_size1.44466880
52MP0003283_abnormal_digestive_organ1.43557530
53MP0002086_abnormal_extraembryonic_tissu1.43393179
54MP0010307_abnormal_tumor_latency1.42013934
55MP0002092_abnormal_eye_morphology1.41819087
56MP0005501_abnormal_skin_physiology1.41535478
57MP0003935_abnormal_craniofacial_develop1.40813830
58MP0002254_reproductive_system_inflammat1.38222186
59MP0006054_spinal_hemorrhage1.37803144
60MP0003942_abnormal_urinary_system1.36792502
61MP0003567_abnormal_fetal_cardiomyocyte1.36301498
62MP0003937_abnormal_limbs/digits/tail_de1.35239775
63MP0002932_abnormal_joint_morphology1.34788450
64MP0001346_abnormal_lacrimal_gland1.32075151
65MP0003861_abnormal_nervous_system1.31875624
66MP0002653_abnormal_ependyma_morphology1.27941610
67MP0004808_abnormal_hematopoietic_stem1.27312315
68MP0002080_prenatal_lethality1.25776832
69MP0002233_abnormal_nose_morphology1.24233714
70MP0009703_decreased_birth_body1.23763553
71MP0003941_abnormal_skin_development1.21143993
72MP0002697_abnormal_eye_size1.19154252
73MP0004233_abnormal_muscle_weight1.18751071
74MP0003755_abnormal_palate_morphology1.18338716
75MP0002060_abnormal_skin_morphology1.17845409
76MP0000049_abnormal_middle_ear1.15985319
77MP0005248_abnormal_Harderian_gland1.15595179
78MP0009672_abnormal_birth_weight1.15508271
79MP0000534_abnormal_ureter_morphology1.13189555
80MP0000432_abnormal_head_morphology1.12920873
81MP0000490_abnormal_crypts_of1.12425565
82MP0000762_abnormal_tongue_morphology1.11402098
83MP0005187_abnormal_penis_morphology1.11258968
84MP0002249_abnormal_larynx_morphology1.07717911
85MP0009379_abnormal_foot_pigmentation1.07116471
86MP0002111_abnormal_tail_morphology1.07111761
87MP0000516_abnormal_urinary_system1.06860246
88MP0005367_renal/urinary_system_phenotyp1.06860246
89MP0003122_maternal_imprinting1.06179791
90MP0002116_abnormal_craniofacial_bone1.06083004
91MP0002282_abnormal_trachea_morphology1.05562604
92MP0001286_abnormal_eye_development1.04705176
93MP0008932_abnormal_embryonic_tissue1.03571670
94MP0002925_abnormal_cardiovascular_devel1.03492603
95MP0000678_abnormal_parathyroid_gland1.03445494
96MP0000579_abnormal_nail_morphology1.03401994
97MP0008057_abnormal_DNA_replication1.02142171
98MP0008770_decreased_survivor_rate1.01670185
99MP0008961_abnormal_basal_metabolism1.00690238
100MP0005666_abnormal_adipose_tissue1.00417795
101MP0000767_abnormal_smooth_muscle1.00341294
102MP0002396_abnormal_hematopoietic_system0.99370892
103MP0002081_perinatal_lethality0.98468181
104MP0003566_abnormal_cell_adhesion0.97053571
105MP0005058_abnormal_lysosome_morphology0.94797594
106MP0005621_abnormal_cell_physiology0.93756458
107MP0001216_abnormal_epidermal_layer0.93530792
108MP0000462_abnormal_digestive_system0.93482054
109MP0003303_peritoneal_inflammation0.92809784
110MP0002098_abnormal_vibrissa_morphology0.92523200
111MP0002114_abnormal_axial_skeleton0.92408837
112MP0009250_abnormal_appendicular_skeleto0.91816512
113MP0009384_cardiac_valve_regurgitation0.89987192
114MP0001348_abnormal_lacrimal_gland0.89302875
115MP0003091_abnormal_cell_migration0.87521478
116MP0004185_abnormal_adipocyte_glucose0.86971062
117MP0005257_abnormal_intraocular_pressure0.85567299
118MP0001915_intracranial_hemorrhage0.85399322
119MP0003315_abnormal_perineum_morphology0.85176281
120MP0000703_abnormal_thymus_morphology0.84724698
121MP0003279_aneurysm0.84332575
122MP0009931_abnormal_skin_appearance0.83389237
123MP0002089_abnormal_postnatal_growth/wei0.83267143
124MP0010630_abnormal_cardiac_muscle0.81979824
125MP0000313_abnormal_cell_death0.81482895
126MP0008877_abnormal_DNA_methylation0.80632212
127MP0004264_abnormal_extraembryonic_tissu0.80243213
128MP0001340_abnormal_eyelid_morphology0.80228339
129MP0001299_abnormal_eye_distance/0.80163195
130MP0000003_abnormal_adipose_tissue0.79487950
131MP0005508_abnormal_skeleton_morphology0.77194729

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.90585119
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.90585119
3Hyperacusis (HP:0010780)3.71031978
4Renal duplication (HP:0000075)3.58876275
5Abnormality of the 4th metacarpal (HP:0010012)3.01545943
6Renovascular hypertension (HP:0100817)2.86630055
7Shallow orbits (HP:0000586)2.85324733
8Premature rupture of membranes (HP:0001788)2.77106747
9Elfin facies (HP:0004428)2.76326060
10Subacute progressive viral hepatitis (HP:0006572)2.71989369
11Increased nuchal translucency (HP:0010880)2.69795722
12Overriding aorta (HP:0002623)2.64011647
13Insomnia (HP:0100785)2.62900441
14Colon cancer (HP:0003003)2.60979047
15Bowel diverticulosis (HP:0005222)2.60703630
16Broad face (HP:0000283)2.59886633
17Turricephaly (HP:0000262)2.59091639
18Cerebral aneurysm (HP:0004944)2.49275061
19Disproportionate tall stature (HP:0001519)2.48657428
20Ankyloglossia (HP:0010296)2.47621794
21Long palpebral fissure (HP:0000637)2.47364487
22Broad metatarsal (HP:0001783)2.34516167
23Ependymoma (HP:0002888)2.33478656
24Abnormality of the phalanges of the hallux (HP:0010057)2.33410943
25Spinal cord lesions (HP:0100561)2.32728364
26Syringomyelia (HP:0003396)2.32728364
27Flat cornea (HP:0007720)2.29448489
28Hallux valgus (HP:0001822)2.27570603
29Protrusio acetabuli (HP:0003179)2.27194072
30Abnormality of the astrocytes (HP:0100707)2.25758448
31Astrocytoma (HP:0009592)2.25758448
32Deviation of the hallux (HP:0010051)2.25565082
33Pelvic girdle muscle weakness (HP:0003749)2.25288554
34Pointed chin (HP:0000307)2.24216608
35Flat acetabular roof (HP:0003180)2.21312551
36Bladder diverticulum (HP:0000015)2.21283696
37Heterotopia (HP:0002282)2.21220559
38Abnormality of oral frenula (HP:0000190)2.19850213
39High anterior hairline (HP:0009890)2.19782865
40Increased density of long bones (HP:0006392)2.15914281
41Genu recurvatum (HP:0002816)2.13165041
42Mitral valve prolapse (HP:0001634)2.12667287
43Thin bony cortex (HP:0002753)2.12037919
44Malignant gastrointestinal tract tumors (HP:0006749)2.11193378
45Gastrointestinal carcinoma (HP:0002672)2.11193378
46Thin ribs (HP:0000883)2.11175239
47Abnormality of the diencephalon (HP:0010662)2.10071391
48Partial duplication of thumb phalanx (HP:0009944)2.08106547
49Broad thumb (HP:0011304)2.05234249
50Abnormality of the thoracic spine (HP:0100711)2.04673591
51Deviation of the thumb (HP:0009603)2.03893593
52Medulloblastoma (HP:0002885)2.03638191
53Partial duplication of the phalanx of hand (HP:0009999)2.03198007
54Coronal craniosynostosis (HP:0004440)2.02633097
55Vertebral compression fractures (HP:0002953)2.02371200
56Natal tooth (HP:0000695)2.01892565
57Choanal stenosis (HP:0000452)2.01626803
58Advanced eruption of teeth (HP:0006288)2.00122912
59Selective tooth agenesis (HP:0001592)1.98339805
60Macroorchidism (HP:0000053)1.97229379
61Facial hemangioma (HP:0000329)1.94553309
62Proximal placement of thumb (HP:0009623)1.94355866
63Atresia of the external auditory canal (HP:0000413)1.92408699
64Volvulus (HP:0002580)1.92227585
65Rectal prolapse (HP:0002035)1.91964306
66Abnormality of the lower motor neuron (HP:0002366)1.91911107
67Vertebral arch anomaly (HP:0008438)1.90748021
68Skin tags (HP:0010609)1.90514184
69Asymmetry of the thorax (HP:0001555)1.90344763
70Biconcave vertebral bodies (HP:0004586)1.90101723
71Blue sclerae (HP:0000592)1.89974083
72Obstructive sleep apnea (HP:0002870)1.89635062
73Deep palmar crease (HP:0006191)1.89124085
74Fibrous tissue neoplasm (HP:0012316)1.88455538
75Sacral dimple (HP:0000960)1.88348933
76Transitional cell carcinoma of the bladder (HP:0006740)1.88264737
77Fragile skin (HP:0001030)1.88067931
78Dilatation of the ascending aorta (HP:0005111)1.87796778
79Short nail (HP:0001799)1.87785777
80Missing ribs (HP:0000921)1.86069651
81Ulnar bowing (HP:0003031)1.85895768
82Broad palm (HP:0001169)1.84648912
83Fibroma (HP:0010614)1.83259598
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.82665843
85Trigonocephaly (HP:0000243)1.82637967
86Persistence of primary teeth (HP:0006335)1.82065971
87Bladder neoplasm (HP:0009725)1.81087632
88Bladder carcinoma (HP:0002862)1.81087632
89Abnormality of the fingertips (HP:0001211)1.81051530
90Abnormal ossification of hand bones (HP:0005921)1.80853851
91Short phalanx of the thumb (HP:0009660)1.80535528
92Abnormality of the hip-girdle musculature (HP:0001445)1.80459955
93Abnormality of the musculature of the pelvis (HP:0001469)1.80459955
94Megalocornea (HP:0000485)1.80440279
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79011282
96Spina bifida occulta (HP:0003298)1.78562296
97Broad phalanges of the hand (HP:0009768)1.78482470
98Patellar dislocation (HP:0002999)1.77983042
99Atrophic scars (HP:0001075)1.77780966
100Trismus (HP:0000211)1.77553742
101Cervical subluxation (HP:0003308)1.77456355
102Overlapping toe (HP:0001845)1.75870855
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.75067281
104Obsessive-compulsive behavior (HP:0000722)1.74805512
105Short 1st metacarpal (HP:0010034)1.73228729
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73228729
107Thoracic kyphosis (HP:0002942)1.72988771
108Dislocated radial head (HP:0003083)1.72905393
109Uterine leiomyosarcoma (HP:0002891)1.72868889
110Leiomyosarcoma (HP:0100243)1.72868889
111Buphthalmos (HP:0000557)1.72141124
112Germ cell neoplasia (HP:0100728)1.71886910
113Intestinal polyp (HP:0005266)1.71721238
114Achilles tendon contracture (HP:0001771)1.70088454
115Bronchomalacia (HP:0002780)1.69977327
116Abnormality of the calcaneus (HP:0008364)1.69362320
117Sparse lateral eyebrow (HP:0005338)1.68268803
118Ankle contracture (HP:0006466)1.68232074
119Broad finger (HP:0001500)1.67849766
120Skull defect (HP:0001362)1.67710339
121Capillary hemangiomas (HP:0005306)1.67677838
122Enlarged penis (HP:0000040)1.67624764
123Sandal gap (HP:0001852)1.67139752
124Hepatoblastoma (HP:0002884)1.66067854
125Joint laxity (HP:0001388)1.65916124
126Basal cell carcinoma (HP:0002671)1.65761865
127Osteolytic defects of the hand bones (HP:0009699)1.65220229
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.65220229
129Breast hypoplasia (HP:0003187)1.64961413
130Preauricular skin tag (HP:0000384)1.64736558
131Mitral regurgitation (HP:0001653)1.64265427
132Abnormality of the distal phalanges of the toes (HP:0010182)1.64218511
133Neoplasm of the oral cavity (HP:0100649)1.63877817
134Midface retrusion (HP:0011800)1.63289534
135Long eyelashes (HP:0000527)1.63030906
136Urethral obstruction (HP:0000796)1.62811618
137Delayed cranial suture closure (HP:0000270)1.62780788
138Wormian bones (HP:0002645)1.62389836
139Neoplasm of striated muscle (HP:0009728)1.62009316
140Arnold-Chiari malformation (HP:0002308)1.61983248
141Broad long bones (HP:0005622)1.60733810
142Flared metaphyses (HP:0003015)1.60653256
143Intestinal polyposis (HP:0200008)1.60228468
144Abnormality of the radial head (HP:0003995)1.60159295
145Biliary tract neoplasm (HP:0100574)1.59588997
146Pseudobulbar signs (HP:0002200)1.59214024
147Hyperextensible skin (HP:0000974)1.58990703
148Bicuspid aortic valve (HP:0001647)1.58440063
149Premature skin wrinkling (HP:0100678)1.58428938
150Hypoplastic labia majora (HP:0000059)1.58372208
151Supernumerary ribs (HP:0005815)1.57946479
152Cutis marmorata (HP:0000965)1.57853594
153High pitched voice (HP:0001620)1.57768685
154Broad phalanx (HP:0006009)1.56903360
155Broad distal phalanx of finger (HP:0009836)1.56758853
156Glioma (HP:0009733)1.56443637
157Abnormal number of incisors (HP:0011064)1.56430795
158Angiofibromas (HP:0010615)1.55505879
159Abnormality of carpal bone ossification (HP:0006257)1.55255668
160Bowing of the arm (HP:0006488)1.54695366
161Bowed forearm bones (HP:0003956)1.54695366
162Precocious puberty (HP:0000826)1.53683447
163Abnormality of the parietal bone (HP:0002696)1.52749270
164Abnormal vertebral ossification (HP:0100569)1.51524117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.46872858
2MAP3K104.41478611
3SMG14.18907138
4TRIB33.99545804
5PKN23.41336199
6PRPF4B3.29936170
7CDK122.94873251
8CDC72.57264775
9IRAK32.17399153
10LATS12.09210882
11ICK1.87918266
12PDGFRA1.87562829
13NEK21.86634412
14SCYL21.78866516
15RIPK11.71830413
16PTK61.70766539
17LATS21.64957223
18PASK1.58653361
19DYRK31.56343385
20RPS6KB21.54960185
21ALK1.53969931
22FGFR41.48767929
23TYRO31.42534601
24CDK61.41948856
25MTOR1.34480810
26NME21.30642190
27DDR21.26061126
28SRPK11.26047147
29CDK41.25304340
30TTN1.24269223
31TAOK11.23892589
32ERBB31.21309984
33LRRK21.11966238
34DYRK1B1.10179553
35RPS6KA41.09940311
36PRKD21.04835202
37SIK21.01373421
38MARK10.99919690
39PAK20.99052918
40CDK90.98322608
41TLK10.97524562
42TAF10.96664894
43TTK0.95449443
44MKNK10.95279291
45KSR10.94456192
46PRKD30.94245319
47PAK40.93673042
48CHEK20.93207640
49BMX0.92479909
50TGFBR10.92301185
51CDK70.92149652
52IRAK20.91800797
53CHEK10.91578462
54HIPK20.91256974
55MKNK20.91093297
56PDGFRB0.91088010
57MAP3K80.90533541
58STK100.90221421
59BRD40.89965328
60GRK60.87958603
61NTRK10.86420139
62EPHB20.86006880
63TAOK20.85461157
64FGFR10.83404639
65STK30.82480811
66MAP2K30.81929979
67ILK0.78622944
68CLK10.78242995
69RPS6KC10.78073883
70RPS6KL10.78073883
71DMPK0.75510540
72AURKB0.75477329
73CDK20.74122988
74MAP3K90.73100474
75RET0.72394311
76FGFR30.72361718
77ATR0.72006869
78MAP3K130.70718836
79UHMK10.70694405
80KSR20.70572775
81CDC42BPA0.67308267
82VRK20.67096910
83FGFR20.65363179
84STK40.64728179
85ATM0.62854452
86TSSK60.62565148
87PLK10.60730049
88MAP2K20.58998711
89FRK0.58962387
90ERBB20.57640350
91SIK10.55394201
92BRAF0.55180634
93RPS6KA10.53832726
94AKT20.53529112
95RPS6KA20.52864501
96AURKA0.51074751
97CAMK1G0.50818885
98MELK0.50732560
99PIM10.50456965
100RPS6KA60.49717974
101CDK10.49524987
102MARK20.48779594
103BUB10.48158497
104PRKCI0.47318327
105PLK30.47262163
106MAP4K10.47191231
107CSNK1A1L0.46389811
108CSNK1D0.45810915
109CSNK1E0.45786903
110MAP3K10.45709725
111PRKDC0.45376824
112PTK20.45146135
113EPHA20.45112490
114PAK60.42570752
115MAP3K60.40763866
116MAPK140.40307795
117DYRK20.39991989
118MAPK110.39004052
119MAP3K20.38302820
120ERN10.37728019
121CAMK1D0.37433944
122STK110.37424954
123MAPK90.37365480
124CSNK1G20.37287021
125FLT30.36803510
126PIM20.36486187
127LMTK20.35739744
128SGK30.34384948
129CDK11A0.31443300
130NEK90.30376502
131ARAF0.30358339
132GSK3A0.29210271
133PDPK10.28365219
134MOS0.27514291

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030152.22081829
2Chronic myeloid leukemia_Homo sapiens_hsa052202.19278342
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18467615
4Cell cycle_Homo sapiens_hsa041101.82590797
5MicroRNAs in cancer_Homo sapiens_hsa052061.80267470
6Spliceosome_Homo sapiens_hsa030401.78476653
7Colorectal cancer_Homo sapiens_hsa052101.76729557
8Basal cell carcinoma_Homo sapiens_hsa052171.75153630
9Systemic lupus erythematosus_Homo sapiens_hsa053221.73247623
10RNA transport_Homo sapiens_hsa030131.70188661
11Endometrial cancer_Homo sapiens_hsa052131.66203784
12Hippo signaling pathway_Homo sapiens_hsa043901.66201345
13DNA replication_Homo sapiens_hsa030301.62322804
14mTOR signaling pathway_Homo sapiens_hsa041501.58630530
15Non-small cell lung cancer_Homo sapiens_hsa052231.49421747
16Alcoholism_Homo sapiens_hsa050341.48016697
17Glioma_Homo sapiens_hsa052141.47072033
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46942739
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46491361
20Adherens junction_Homo sapiens_hsa045201.45694214
21Notch signaling pathway_Homo sapiens_hsa043301.45173134
22Small cell lung cancer_Homo sapiens_hsa052221.44645692
23Viral carcinogenesis_Homo sapiens_hsa052031.44060281
24Pancreatic cancer_Homo sapiens_hsa052121.42965089
25Bladder cancer_Homo sapiens_hsa052191.39911645
26Mismatch repair_Homo sapiens_hsa034301.39143032
27Hedgehog signaling pathway_Homo sapiens_hsa043401.35802304
28Other glycan degradation_Homo sapiens_hsa005111.34002499
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.30572686
30Proteoglycans in cancer_Homo sapiens_hsa052051.27047216
31HTLV-I infection_Homo sapiens_hsa051661.26540640
32Viral myocarditis_Homo sapiens_hsa054161.22088410
33One carbon pool by folate_Homo sapiens_hsa006701.19808190
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18189863
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18005527
36TGF-beta signaling pathway_Homo sapiens_hsa043501.17593230
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16172444
38Thyroid cancer_Homo sapiens_hsa052161.16102014
39Base excision repair_Homo sapiens_hsa034101.16030437
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13506279
41Estrogen signaling pathway_Homo sapiens_hsa049151.11674342
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11321569
43Prostate cancer_Homo sapiens_hsa052151.10567561
44Wnt signaling pathway_Homo sapiens_hsa043101.09567012
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.09310159
46Acute myeloid leukemia_Homo sapiens_hsa052211.09076555
47VEGF signaling pathway_Homo sapiens_hsa043701.08793086
48Oocyte meiosis_Homo sapiens_hsa041141.08301238
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07451114
50Prion diseases_Homo sapiens_hsa050201.06982431
51Focal adhesion_Homo sapiens_hsa045101.06702803
52p53 signaling pathway_Homo sapiens_hsa041151.05878417
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02625713
54Renal cell carcinoma_Homo sapiens_hsa052111.00929427
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99205854
56Ribosome_Homo sapiens_hsa030100.98554129
57Prolactin signaling pathway_Homo sapiens_hsa049170.97985779
58Pathways in cancer_Homo sapiens_hsa052000.94956902
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93122701
60ErbB signaling pathway_Homo sapiens_hsa040120.92530505
61Tight junction_Homo sapiens_hsa045300.92496605
62Melanogenesis_Homo sapiens_hsa049160.89710757
63Hepatitis B_Homo sapiens_hsa051610.88897927
64Axon guidance_Homo sapiens_hsa043600.88141505
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87131368
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86446336
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85294652
68Olfactory transduction_Homo sapiens_hsa047400.84513614
69Dorso-ventral axis formation_Homo sapiens_hsa043200.84058324
70Melanoma_Homo sapiens_hsa052180.83395733
71Hepatitis C_Homo sapiens_hsa051600.83201537
72Lysine degradation_Homo sapiens_hsa003100.82453950
73T cell receptor signaling pathway_Homo sapiens_hsa046600.81667436
74FoxO signaling pathway_Homo sapiens_hsa040680.79759828
75Sulfur relay system_Homo sapiens_hsa041220.78766265
76Inositol phosphate metabolism_Homo sapiens_hsa005620.78143126
77Biosynthesis of amino acids_Homo sapiens_hsa012300.78141591
78Choline metabolism in cancer_Homo sapiens_hsa052310.78092863
79Rap1 signaling pathway_Homo sapiens_hsa040150.77336772
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76939970
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75833082
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.74831644
83B cell receptor signaling pathway_Homo sapiens_hsa046620.74820663
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74159060
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.72948747
86Pentose phosphate pathway_Homo sapiens_hsa000300.72404698
87Apoptosis_Homo sapiens_hsa042100.71878772
88Type II diabetes mellitus_Homo sapiens_hsa049300.71198582
89Insulin signaling pathway_Homo sapiens_hsa049100.70637836
90Gap junction_Homo sapiens_hsa045400.70188139
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69946926
92MAPK signaling pathway_Homo sapiens_hsa040100.68839005
93RNA degradation_Homo sapiens_hsa030180.68528403
94Nucleotide excision repair_Homo sapiens_hsa034200.67920574
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67208276
96AMPK signaling pathway_Homo sapiens_hsa041520.67057976
97GnRH signaling pathway_Homo sapiens_hsa049120.66392523
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66120227
99Fanconi anemia pathway_Homo sapiens_hsa034600.64126376
100Toxoplasmosis_Homo sapiens_hsa051450.63163162
101Shigellosis_Homo sapiens_hsa051310.62618392
102Epstein-Barr virus infection_Homo sapiens_hsa051690.60820358
103Antigen processing and presentation_Homo sapiens_hsa046120.60712095
104N-Glycan biosynthesis_Homo sapiens_hsa005100.59961412
105Insulin resistance_Homo sapiens_hsa049310.59770268
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.59609538
107Platelet activation_Homo sapiens_hsa046110.59090866
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58611896
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58182369
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57811523
111ECM-receptor interaction_Homo sapiens_hsa045120.57621955
112Non-homologous end-joining_Homo sapiens_hsa034500.57467154
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57127785
114Influenza A_Homo sapiens_hsa051640.56151632
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56066327
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55023325
117Homologous recombination_Homo sapiens_hsa034400.54840963
118Amoebiasis_Homo sapiens_hsa051460.53732166
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53426530
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.53410726
121Fructose and mannose metabolism_Homo sapiens_hsa000510.53200034
122Herpes simplex infection_Homo sapiens_hsa051680.51760414

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