RBM17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.64993812
2formation of translation preinitiation complex (GO:0001731)4.44022229
3maturation of SSU-rRNA (GO:0030490)4.43771902
4folic acid-containing compound biosynthetic process (GO:0009396)4.43375801
5DNA replication initiation (GO:0006270)4.42366858
6DNA strand elongation involved in DNA replication (GO:0006271)4.41658543
7DNA topological change (GO:0006265)4.31891005
8protein localization to kinetochore (GO:0034501)4.27080337
9ribosomal small subunit assembly (GO:0000028)4.18600940
10DNA strand elongation (GO:0022616)4.17481585
11mitotic metaphase plate congression (GO:0007080)4.16837683
12ribosome assembly (GO:0042255)4.11365876
13nucleobase biosynthetic process (GO:0046112)4.09643655
14mitotic nuclear envelope disassembly (GO:0007077)4.07986419
15viral transcription (GO:0019083)4.02049658
16telomere maintenance via semi-conservative replication (GO:0032201)3.99621930
17translational termination (GO:0006415)3.98376242
18negative regulation of mRNA processing (GO:0050686)3.95341570
19purine nucleobase biosynthetic process (GO:0009113)3.90293247
20DNA replication-dependent nucleosome assembly (GO:0006335)3.83099317
21DNA replication-dependent nucleosome organization (GO:0034723)3.83099317
22DNA replication checkpoint (GO:0000076)3.82448495
23mitotic sister chromatid cohesion (GO:0007064)3.81404194
24nuclear pore organization (GO:0006999)3.79994764
25membrane disassembly (GO:0030397)3.79659107
26nuclear envelope disassembly (GO:0051081)3.79659107
27ribosome biogenesis (GO:0042254)3.79552570
28IMP biosynthetic process (GO:0006188)3.78895096
29ribosomal small subunit biogenesis (GO:0042274)3.77995246
30translational initiation (GO:0006413)3.74412914
31DNA deamination (GO:0045006)3.71720850
32establishment of integrated proviral latency (GO:0075713)3.70731290
33ribonucleoprotein complex biogenesis (GO:0022613)3.70216270
34protein localization to chromosome, centromeric region (GO:0071459)3.67994037
35translational elongation (GO:0006414)3.66356676
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.63079928
37ribosomal large subunit biogenesis (GO:0042273)3.61068694
38nuclear pore complex assembly (GO:0051292)3.58099250
39metaphase plate congression (GO:0051310)3.57730056
403-UTR-mediated mRNA stabilization (GO:0070935)3.57057795
41regulation of transcription from RNA polymerase I promoter (GO:0006356)3.55365243
42telomere maintenance via recombination (GO:0000722)3.55158317
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51730783
44regulation of spindle organization (GO:0090224)3.50863252
45mitotic recombination (GO:0006312)3.47008040
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45842283
47IMP metabolic process (GO:0046040)3.40319573
48negative regulation of mRNA metabolic process (GO:1903312)3.38080506
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37644946
50rRNA processing (GO:0006364)3.34091307
51telomere maintenance via telomere lengthening (GO:0010833)3.32329689
52termination of RNA polymerase II transcription (GO:0006369)3.31367936
53protein targeting to ER (GO:0045047)3.27477186
54DNA replication-independent nucleosome organization (GO:0034724)3.27245950
55DNA replication-independent nucleosome assembly (GO:0006336)3.27245950
56mitotic sister chromatid segregation (GO:0000070)3.27134210
57cotranslational protein targeting to membrane (GO:0006613)3.26417138
58negative regulation of histone methylation (GO:0031061)3.25646121
59chromatin remodeling at centromere (GO:0031055)3.24470030
60rRNA metabolic process (GO:0016072)3.23403397
61regulation of histone H3-K9 methylation (GO:0051570)3.22421628
62CENP-A containing nucleosome assembly (GO:0034080)3.22099042
63spliceosomal snRNP assembly (GO:0000387)3.22004660
64regulation of RNA export from nucleus (GO:0046831)3.19506536
65DNA duplex unwinding (GO:0032508)3.19435480
66mitotic chromosome condensation (GO:0007076)3.17760343
67DNA geometric change (GO:0032392)3.17221578
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17039634
69chromosome condensation (GO:0030261)3.16967001
70establishment of viral latency (GO:0019043)3.16434095
71cellular protein complex disassembly (GO:0043624)3.16177717
72establishment of chromosome localization (GO:0051303)3.15678942
73RNA stabilization (GO:0043489)3.15363944
74mRNA stabilization (GO:0048255)3.15363944
75folic acid metabolic process (GO:0046655)3.13325802
76viral life cycle (GO:0019058)3.12029255
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11369230
78negative regulation of RNA splicing (GO:0033119)3.08800887
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.08355344
80protein localization to endoplasmic reticulum (GO:0070972)3.06924308
81sister chromatid segregation (GO:0000819)3.06011313
82kinetochore organization (GO:0051383)3.04489711
83mRNA splice site selection (GO:0006376)3.02636252
84negative regulation of erythrocyte differentiation (GO:0045647)3.01533196
85regulation of mitotic spindle organization (GO:0060236)2.98771480
86nuclear envelope organization (GO:0006998)2.98551960
87* RNA splicing, via transesterification reactions (GO:0000375)2.98166206
88* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.97660417
89* mRNA splicing, via spliceosome (GO:0000398)2.97660417
90attachment of spindle microtubules to kinetochore (GO:0008608)2.96548996
91protein complex disassembly (GO:0043241)2.95742488
92mRNA export from nucleus (GO:0006406)2.94428555
93viral mRNA export from host cell nucleus (GO:0046784)2.94402503
94regulation of translational termination (GO:0006449)2.94337388
95positive regulation of chromosome segregation (GO:0051984)2.94256043
96spliceosomal tri-snRNP complex assembly (GO:0000244)2.91798301
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.90419593
98chromatin assembly or disassembly (GO:0006333)2.90246861
99nuclear-transcribed mRNA catabolic process (GO:0000956)2.89022756
100histone H2B ubiquitination (GO:0033523)2.88348810
101RNA export from nucleus (GO:0006405)2.84544078
102negative regulation of chromosome segregation (GO:0051985)2.83801080
103regulation of chromosome segregation (GO:0051983)2.83241738
104spindle checkpoint (GO:0031577)2.83065889
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.80329997
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80329997
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80329997
108negative regulation of sister chromatid segregation (GO:0033046)2.80329997
109regulation of nucleobase-containing compound transport (GO:0032239)2.80100748
110histone exchange (GO:0043486)2.79864375
111macromolecular complex disassembly (GO:0032984)2.79853043
112spliceosomal complex assembly (GO:0000245)2.78025014
113DNA packaging (GO:0006323)2.77739447
114spindle assembly checkpoint (GO:0071173)2.77328093
115mitotic spindle assembly checkpoint (GO:0007094)2.76966401
116RNA catabolic process (GO:0006401)2.76586461
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75551225
118translation (GO:0006412)2.75087323
119DNA conformation change (GO:0071103)2.75055428
120mitotic spindle checkpoint (GO:0071174)2.74387719
121mRNA catabolic process (GO:0006402)2.74031244
122cell cycle G1/S phase transition (GO:0044843)2.74029713
123G1/S transition of mitotic cell cycle (GO:0000082)2.74029713
124chromosome segregation (GO:0007059)2.73286730
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.73281824
126transcription-coupled nucleotide-excision repair (GO:0006283)2.73117670
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.73053961
128regulation of mRNA stability (GO:0043488)2.71692001
129dosage compensation (GO:0007549)2.71671476
130DNA ligation (GO:0006266)2.70800119
131regulation of RNA stability (GO:0043487)2.70220617
132Peyers patch development (GO:0048541)2.68730860
133mucosal-associated lymphoid tissue development (GO:0048537)2.68730860
134NIK/NF-kappaB signaling (GO:0038061)2.68692654
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67123137
136DNA synthesis involved in DNA repair (GO:0000731)2.66886797
137purine nucleotide salvage (GO:0032261)2.63602893
138transcription from mitochondrial promoter (GO:0006390)2.62104782
139ATP-dependent chromatin remodeling (GO:0043044)2.60645164
140positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60587192
141regulation of vitamin D biosynthetic process (GO:0060556)2.57971050
142pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.56093794
143V(D)J recombination (GO:0033151)2.55828522
144protein localization to chromosome (GO:0034502)2.55526389
145nucleosome disassembly (GO:0006337)2.52278571
146protein-DNA complex disassembly (GO:0032986)2.52278571
147pore complex assembly (GO:0046931)2.51563133
148* RNA splicing (GO:0008380)2.51385428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.02302471
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34299277
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.00690999
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77885508
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45980312
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06702589
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98002488
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77616227
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70746155
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63243960
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.61952648
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.60883782
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.59333575
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.57763530
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47795142
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44516215
17XRN2_22483619_ChIP-Seq_HELA_Human2.39494807
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38824133
19AR_21909140_ChIP-Seq_LNCAP_Human2.18201718
20VDR_23849224_ChIP-Seq_CD4+_Human2.12710067
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05666173
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04388365
23MYC_22102868_ChIP-Seq_BL_Human2.02585466
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02301654
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.98528232
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91454334
27DCP1A_22483619_ChIP-Seq_HELA_Human1.90453950
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90040361
29GABP_19822575_ChIP-Seq_HepG2_Human1.83494006
30FOXP3_21729870_ChIP-Seq_TREG_Human1.81456281
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80299710
32TTF2_22483619_ChIP-Seq_HELA_Human1.76524226
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75933182
34* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73037327
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70800729
36* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70567795
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68091600
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66459201
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65519300
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64584958
41CIITA_25753668_ChIP-Seq_RAJI_Human1.61882084
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61616907
43ELK1_19687146_ChIP-ChIP_HELA_Human1.52963081
44KDM5A_27292631_Chip-Seq_BREAST_Human1.51820854
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51005008
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44012061
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43552533
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43385604
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43274431
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40469329
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39873959
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39779278
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38596432
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38551041
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33679825
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33048422
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30821500
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.30265157
59* MAF_26560356_Chip-Seq_TH1_Human1.28261340
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28189442
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.27887803
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27789884
63TFEB_21752829_ChIP-Seq_HELA_Human1.26685237
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26345602
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22328623
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22328623
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22328623
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22147419
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21632990
70VDR_21846776_ChIP-Seq_THP-1_Human1.19723553
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18910804
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17987078
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17499639
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13045986
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12907436
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12181771
77* UTX_26944678_Chip-Seq_JUKART_Human1.12000044
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11751339
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11182491
80TCF7_22412390_ChIP-Seq_EML_Mouse1.10745810
81* MAF_26560356_Chip-Seq_TH2_Human1.10618681
82NCOR1_26117541_ChIP-Seq_K562_Human1.08470584
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08445088
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08196121
85VDR_24763502_ChIP-Seq_THP-1_Human1.07930400
86* MYB_26560356_Chip-Seq_TH2_Human1.07456243
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07389100
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.06918083
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06259553
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05540962
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.05457278
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05185322
93MYB_26560356_Chip-Seq_TH1_Human1.04440792
94BP1_19119308_ChIP-ChIP_Hs578T_Human1.04080929
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02417844
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01458248
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99644974
98SCL_19346495_ChIP-Seq_HPC-7_Human0.99015941
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98943219
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98337866
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97749384
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96805014
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96219775
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95926145
105KDM2B_26808549_Chip-Seq_DND41_Human0.95788372
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95407685
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94962055
108* ELK3_25401928_ChIP-Seq_HUVEC_Human0.93696988
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.93302147
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93229011
111SPI1_23547873_ChIP-Seq_NB4_Human0.93062443
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92833012
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.90294381
114ZNF263_19887448_ChIP-Seq_K562_Human0.89622346
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.88211193
116RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86087870
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84765901
118* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83458067
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83347276
120* CHD1_26751641_Chip-Seq_LNCaP_Human0.83167630
121MYC_18940864_ChIP-ChIP_HL60_Human0.83148423
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82876165
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81958585
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80442354
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80295979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49527145
2MP0004957_abnormal_blastocyst_morpholog4.33893843
3MP0003111_abnormal_nucleus_morphology4.18390173
4MP0010094_abnormal_chromosome_stability4.17399420
5MP0003077_abnormal_cell_cycle3.85107680
6MP0008057_abnormal_DNA_replication3.60515837
7MP0010352_gastrointestinal_tract_polyps3.00842059
8MP0008007_abnormal_cellular_replicative2.90926253
9MP0003303_peritoneal_inflammation2.77647120
10MP0008058_abnormal_DNA_repair2.66222371
11MP0008932_abnormal_embryonic_tissue2.50167464
12MP0002396_abnormal_hematopoietic_system2.49644221
13MP0003123_paternal_imprinting2.49586562
14MP0001730_embryonic_growth_arrest2.45707420
15MP0000350_abnormal_cell_proliferation2.38875401
16MP0005451_abnormal_body_composition2.21622377
17MP0010307_abnormal_tumor_latency2.13940924
18MP0003656_abnormal_erythrocyte_physiolo2.09333747
19MP0001697_abnormal_embryo_size1.84570568
20MP0005380_embryogenesis_phenotype1.82184247
21MP0001672_abnormal_embryogenesis/_devel1.82184247
22MP0001835_abnormal_antigen_presentation1.79559176
23MP0002080_prenatal_lethality1.68629829
24MP0003984_embryonic_growth_retardation1.66583174
25MP0002148_abnormal_hypersensitivity_rea1.65645817
26MP0003300_gastrointestinal_ulcer1.65438535
27MP0005076_abnormal_cell_differentiation1.65192563
28MP0005058_abnormal_lysosome_morphology1.65098936
29MP0000490_abnormal_crypts_of1.63785721
30MP0002088_abnormal_embryonic_growth/wei1.63272998
31MP0004808_abnormal_hematopoietic_stem1.61952649
32MP0004185_abnormal_adipocyte_glucose1.61836049
33MP0002084_abnormal_developmental_patter1.59912415
34MP0003806_abnormal_nucleotide_metabolis1.59244168
35MP0003786_premature_aging1.58325996
36MP0002085_abnormal_embryonic_tissue1.58150096
37MP0003567_abnormal_fetal_cardiomyocyte1.56254431
38MP0004197_abnormal_fetal_growth/weight/1.54484916
39MP0002086_abnormal_extraembryonic_tissu1.51335772
40MP0003718_maternal_effect1.50573342
41MP0010030_abnormal_orbit_morphology1.50311255
42MP0003705_abnormal_hypodermis_morpholog1.49934440
43MP0005000_abnormal_immune_tolerance1.49778815
44MP0002019_abnormal_tumor_incidence1.45753664
45MP0000313_abnormal_cell_death1.44197676
46MP0008877_abnormal_DNA_methylation1.42771301
47MP0003453_abnormal_keratinocyte_physiol1.41683459
48MP0005387_immune_system_phenotype1.41058107
49MP0001790_abnormal_immune_system1.41058107
50MP0002009_preneoplasia1.39966465
51MP0009333_abnormal_splenocyte_physiolog1.39071649
52MP0005666_abnormal_adipose_tissue1.37394134
53MP0005397_hematopoietic_system_phenotyp1.33529266
54MP0001545_abnormal_hematopoietic_system1.33529266
55MP0001873_stomach_inflammation1.32788098
56MP0002723_abnormal_immune_serum1.28852991
57MP0008260_abnormal_autophagy1.27331607
58MP0001727_abnormal_embryo_implantation1.26022247
59MP0004947_skin_inflammation1.22959258
60MP0003763_abnormal_thymus_physiology1.21619567
61MP0003121_genomic_imprinting1.19791061
62MP0005025_abnormal_response_to1.18386883
63MP0000537_abnormal_urethra_morphology1.17497023
64MP0004510_myositis1.16619428
65MP0000703_abnormal_thymus_morphology1.16377208
66MP0006036_abnormal_mitochondrial_physio1.14923692
67MP0003890_abnormal_embryonic-extraembry1.13063546
68MP0009785_altered_susceptibility_to1.11231051
69MP0002398_abnormal_bone_marrow1.10940576
70MP0000358_abnormal_cell_content/1.07548800
71MP0003221_abnormal_cardiomyocyte_apopto1.06464379
72MP0005671_abnormal_response_to1.04774380
73MP0002722_abnormal_immune_system1.03359828
74MP0001293_anophthalmia1.03084220
75MP0005023_abnormal_wound_healing1.01146318
76MP0002877_abnormal_melanocyte_morpholog0.99718464
77MP0008961_abnormal_basal_metabolism0.98862387
78MP0001346_abnormal_lacrimal_gland0.97299890
79MP0000689_abnormal_spleen_morphology0.97010907
80MP0002419_abnormal_innate_immunity0.97010350
81MP0003119_abnormal_digestive_system0.96705480
82MP0009053_abnormal_anal_canal0.96667957
83MP0002210_abnormal_sex_determination0.95662663
84MP0000858_altered_metastatic_potential0.94435555
85MP0005384_cellular_phenotype0.92378646
86MP0005621_abnormal_cell_physiology0.90398910
87MP0009278_abnormal_bone_marrow0.88609669
88MP0001145_abnormal_male_reproductive0.88043142
89MP0009672_abnormal_birth_weight0.86909253
90MP0001849_ear_inflammation0.86683531
91MP0002429_abnormal_blood_cell0.86332971
92MP0003566_abnormal_cell_adhesion0.85847194
93MP0000465_gastrointestinal_hemorrhage0.85246134
94MP0002653_abnormal_ependyma_morphology0.83928375
95MP0010155_abnormal_intestine_physiology0.83687459
96MP0002111_abnormal_tail_morphology0.82772997
97MP0003937_abnormal_limbs/digits/tail_de0.81733765
98MP0006035_abnormal_mitochondrial_morpho0.80853004
99MP0000733_abnormal_muscle_development0.80685573
100MP0005501_abnormal_skin_physiology0.80518276
101MP0001915_intracranial_hemorrhage0.80041109
102MP0006054_spinal_hemorrhage0.77663366
103MP0003315_abnormal_perineum_morphology0.77408513
104MP0005266_abnormal_metabolism0.76804648
105MP0000716_abnormal_immune_system0.74798067
106MP0004233_abnormal_muscle_weight0.74648373
107MP0002796_impaired_skin_barrier0.74250859
108MP0003186_abnormal_redox_activity0.74245511
109MP0000428_abnormal_craniofacial_morphol0.73856992
110MP0000653_abnormal_sex_gland0.72604127
111MP0003183_abnormal_peptide_metabolism0.72534416
112MP0005310_abnormal_salivary_gland0.72165250
113MP0000750_abnormal_muscle_regeneration0.71071470
114MP0009697_abnormal_copulation0.70035387
115MP0009703_decreased_birth_body0.69879452
116MP0005375_adipose_tissue_phenotype0.68941875
117MP0001929_abnormal_gametogenesis0.68309257
118MP0000477_abnormal_intestine_morphology0.68236813
119MP0002138_abnormal_hepatobiliary_system0.67671902
120MP0001845_abnormal_inflammatory_respons0.67011050
121MP0000685_abnormal_immune_system0.66201113
122MP0006082_CNS_inflammation0.66199816
123MP0002092_abnormal_eye_morphology0.65263670
124MP0001800_abnormal_humoral_immune0.63616855
125MP0004264_abnormal_extraembryonic_tissu0.63402466
126MP0001853_heart_inflammation0.62591806
127MP0001119_abnormal_female_reproductive0.61362736
128MP0004133_heterotaxia0.61073084
129MP0006292_abnormal_olfactory_placode0.60121414
130MP0002405_respiratory_system_inflammati0.59823019
131MP0001286_abnormal_eye_development0.58964121
132MP0003436_decreased_susceptibility_to0.58732552
133MP0005389_reproductive_system_phenotype0.55241646
134MP0002452_abnormal_antigen_presenting0.55195741
135MP0003448_altered_tumor_morphology0.54590792
136MP0008770_decreased_survivor_rate0.53857174
137MP0002160_abnormal_reproductive_system0.53744556
138MP0002420_abnormal_adaptive_immunity0.53721691
139MP0001819_abnormal_immune_cell0.53274665
140MP0001348_abnormal_lacrimal_gland0.52822032
141MP0002925_abnormal_cardiovascular_devel0.52477444

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.55271527
2Reticulocytopenia (HP:0001896)4.15627089
3Abnormality of cells of the erythroid lineage (HP:0012130)4.03317787
4Carpal bone hypoplasia (HP:0001498)3.95086113
5Abnormal number of erythroid precursors (HP:0012131)3.70993691
6Breast hypoplasia (HP:0003187)3.50977763
7Microvesicular hepatic steatosis (HP:0001414)3.38043420
8Colon cancer (HP:0003003)3.28587992
9Progressive external ophthalmoplegia (HP:0000590)3.27090091
10Degeneration of anterior horn cells (HP:0002398)3.25380807
11Abnormality of the anterior horn cell (HP:0006802)3.25380807
12Ependymoma (HP:0002888)3.17956958
13Selective tooth agenesis (HP:0001592)3.13594724
14Oral leukoplakia (HP:0002745)3.10805700
15Patellar aplasia (HP:0006443)3.06220254
16Ragged-red muscle fibers (HP:0003200)3.02735035
17Irregular epiphyses (HP:0010582)2.94079158
18Aplasia/Hypoplasia of the patella (HP:0006498)2.89268107
19Medulloblastoma (HP:0002885)2.89175655
20Multiple enchondromatosis (HP:0005701)2.84835483
21Chromsome breakage (HP:0040012)2.80681071
22Mediastinal lymphadenopathy (HP:0100721)2.78286313
23Rough bone trabeculation (HP:0100670)2.76263073
24Recurrent viral infections (HP:0004429)2.75886686
25Trismus (HP:0000211)2.73168043
26Macrocytic anemia (HP:0001972)2.67963621
27Volvulus (HP:0002580)2.65885849
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65766333
29Thrombocytosis (HP:0001894)2.63364101
30Pallor (HP:0000980)2.62439213
31Aplastic anemia (HP:0001915)2.61103934
32Abnormality of chromosome stability (HP:0003220)2.56880291
33Neoplasm of the pancreas (HP:0002894)2.50705239
34Rhabdomyosarcoma (HP:0002859)2.47660526
35Combined immunodeficiency (HP:0005387)2.46577535
36Abnormality of lateral ventricle (HP:0030047)2.44163646
37Myelodysplasia (HP:0002863)2.42875410
38Glossoptosis (HP:0000162)2.39539621
39Meckel diverticulum (HP:0002245)2.38437798
40Cerebral hypomyelination (HP:0006808)2.38283685
41Agnosia (HP:0010524)2.37115631
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36761214
43Deviation of the thumb (HP:0009603)2.35954877
44Absent thumb (HP:0009777)2.35287585
45Proximal placement of thumb (HP:0009623)2.34902595
46Abnormality of the fingertips (HP:0001211)2.34597332
47Impulsivity (HP:0100710)2.32749602
48Abnormality of the preputium (HP:0100587)2.29951387
49Agammaglobulinemia (HP:0004432)2.28794275
50Basal cell carcinoma (HP:0002671)2.28135606
51B lymphocytopenia (HP:0010976)2.26973862
52Abnormality of the ileum (HP:0001549)2.26430209
53Microretrognathia (HP:0000308)2.24355972
54Cortical dysplasia (HP:0002539)2.24295514
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23361461
56Pseudobulbar signs (HP:0002200)2.22735048
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20062175
58Thoracic kyphosis (HP:0002942)2.19665088
59Amaurosis fugax (HP:0100576)2.17843515
6011 pairs of ribs (HP:0000878)2.16492765
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.16368216
62Aplasia/Hypoplasia of the thymus (HP:0010515)2.16112876
63Absent radius (HP:0003974)2.15205506
64Premature graying of hair (HP:0002216)2.14037582
65Atresia of the external auditory canal (HP:0000413)2.12115338
66Missing ribs (HP:0000921)2.10984756
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.10801907
68Shoulder girdle muscle weakness (HP:0003547)2.10728791
69Overlapping toe (HP:0001845)2.07672006
70Personality changes (HP:0000751)2.07357379
71Dysphonia (HP:0001618)2.06531581
72Cutis marmorata (HP:0000965)2.06079770
73Small epiphyses (HP:0010585)2.04650323
74Cellulitis (HP:0100658)2.03245893
75Pancytopenia (HP:0001876)2.02795037
76Prominent nose (HP:0000448)2.01467225
77Entropion (HP:0000621)2.00714878
78Abnormal number of incisors (HP:0011064)2.00651152
79Acute lymphatic leukemia (HP:0006721)2.00647743
80Squamous cell carcinoma (HP:0002860)1.99564346
81Abnormality of the calcaneus (HP:0008364)1.99259932
82IgA deficiency (HP:0002720)1.98872128
83Disinhibition (HP:0000734)1.98687992
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98171597
85Premature ovarian failure (HP:0008209)1.96577345
86Hypertensive crisis (HP:0100735)1.96542737
87Acute myeloid leukemia (HP:0004808)1.96485504
88Absent forearm bone (HP:0003953)1.96180726
89Aplasia involving forearm bones (HP:0009822)1.96180726
90Astrocytoma (HP:0009592)1.95776999
91Abnormality of the astrocytes (HP:0100707)1.95776999
92Bone marrow hypocellularity (HP:0005528)1.95623429
93Colitis (HP:0002583)1.94790606
94Increased nuchal translucency (HP:0010880)1.94097056
95Pelvic girdle muscle weakness (HP:0003749)1.93820869
96Slender long bone (HP:0003100)1.93410407
97Abnormal trabecular bone morphology (HP:0100671)1.92772286
98Secondary amenorrhea (HP:0000869)1.92444918
99Tracheoesophageal fistula (HP:0002575)1.91541493
100Duodenal stenosis (HP:0100867)1.91335333
101Small intestinal stenosis (HP:0012848)1.91335333
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91075159
103Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90911765
104Gout (HP:0001997)1.89342667
105Increased serum pyruvate (HP:0003542)1.88781705
106Deep palmar crease (HP:0006191)1.88704773
107Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88485451
108Absent epiphyses (HP:0010577)1.88485451
109Upper motor neuron abnormality (HP:0002127)1.88311186
110Glioma (HP:0009733)1.87641407
111Fatigue (HP:0012378)1.86992123
112Cellular immunodeficiency (HP:0005374)1.86184298
113Abnormality of the thoracic spine (HP:0100711)1.85085172
114Increased IgM level (HP:0003496)1.83594361
115Abnormality of B cell number (HP:0010975)1.83493854
116Insomnia (HP:0100785)1.83327443
117Reticulocytosis (HP:0001923)1.82572124
118Sparse lateral eyebrow (HP:0005338)1.82070057
119Lymphoma (HP:0002665)1.81853268
120Cutaneous melanoma (HP:0012056)1.81690589
121Calcaneovalgus deformity (HP:0001848)1.81638677
122Gastrointestinal stroma tumor (HP:0100723)1.81500851
123Sloping forehead (HP:0000340)1.81389182
124Impaired proprioception (HP:0010831)1.81115113
125Cafe-au-lait spot (HP:0000957)1.80959379
126Seborrheic dermatitis (HP:0001051)1.80293852
127Nausea (HP:0002018)1.78388679
128Facial hemangioma (HP:0000329)1.78329090
129Increased serum ferritin (HP:0003281)1.77681830
130Flat occiput (HP:0005469)1.77390861
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.75995079
132Abnormality of the labia minora (HP:0012880)1.75501050
133Abnormality of reticulocytes (HP:0004312)1.75490996
134Diminished motivation (HP:0000745)1.75119223
135Panhypogammaglobulinemia (HP:0003139)1.74323740
136Supernumerary spleens (HP:0009799)1.71984013
137Hepatosplenomegaly (HP:0001433)1.71900271
138Duplication of thumb phalanx (HP:0009942)1.70951781
139Capillary hemangiomas (HP:0005306)1.70799814
140Horseshoe kidney (HP:0000085)1.70282704
141IgM deficiency (HP:0002850)1.70080313
142Neoplasm of striated muscle (HP:0009728)1.69842349
143Hypoparathyroidism (HP:0000829)1.68811969
144Cleft eyelid (HP:0000625)1.68459075
145Respiratory difficulties (HP:0002880)1.68153834
146Oligodactyly (HP:0012165)1.68043783
147Paralysis (HP:0003470)1.67800110
148Flat capital femoral epiphysis (HP:0003370)1.67470231
149External ophthalmoplegia (HP:0000544)1.67161284
150Granulocytopenia (HP:0001913)1.66999648
151Biliary tract neoplasm (HP:0100574)1.66048861
152Stomatitis (HP:0010280)1.64927930
153Neurodegeneration (HP:0002180)1.64866556
154Abnormality of the umbilical cord (HP:0010881)1.64844929
155Achilles tendon contracture (HP:0001771)1.64826010
156Autoimmune hemolytic anemia (HP:0001890)1.64799816
157Progressive muscle weakness (HP:0003323)1.64709338
158Abdominal situs inversus (HP:0003363)1.64017336
159Abnormality of abdominal situs (HP:0011620)1.64017336
160Ankle contracture (HP:0006466)1.63773726
161Cervical subluxation (HP:0003308)1.63575894
162Aplasia/hypoplasia of the humerus (HP:0006507)1.63460275
163Optic nerve coloboma (HP:0000588)1.62921405
164Spinal muscular atrophy (HP:0007269)1.61600583
165Neoplasm of the colon (HP:0100273)1.60330116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.29696502
2WEE14.18718480
3CDC73.82159912
4PRPF4B3.06164650
5NEK22.90410963
6EIF2AK12.49083228
7MAP3K142.47456091
8IRAK32.25372017
9VRK22.24873276
10EEF2K2.19127616
11ACVR1B2.18880060
12MAP3K132.16481233
13TSSK62.14434913
14NME22.13470351
15TTK2.13353591
16RPS6KB22.10596350
17BRSK22.10049639
18PASK2.06060516
19TESK22.05507859
20NEK12.04398257
21SRPK12.02441373
22PLK41.91447555
23PLK11.78575614
24DYRK31.74758754
25SCYL21.73845979
26RPS6KA41.71599980
27CDK71.71386530
28CDK121.68970915
29SMG11.63658024
30EPHA21.62436110
31AURKB1.59026146
32EIF2AK31.57676455
33MKNK11.52522643
34STK101.51163827
35ATR1.49599359
36MAP3K81.45299732
37STK161.41302279
38PKN21.40915833
39CDK41.39682842
40CLK11.35624171
41MAP3K101.35171963
42PLK31.34099434
43FLT31.33231396
44ARAF1.32515604
45CHEK21.28739942
46TGFBR11.27989803
47CHEK11.26035996
48BRSK11.19522261
49PAK41.18063161
50VRK11.15807453
51PBK1.13747938
52TAOK11.12500400
53TAF11.11635402
54AURKA1.11214684
55MOS1.10493268
56MKNK21.06863593
57LRRK21.06472781
58MAP4K11.02229639
59PIM21.01500378
60MAPKAPK30.98132545
61IRAK40.97204935
62TBK10.96657821
63PIM10.95071103
64ALK0.92237888
65ERN10.91334532
66TESK10.90793389
67STK30.85945582
68CDK20.85717871
69IKBKE0.85230797
70BMPR20.83842173
71IKBKB0.80585082
72STK40.79966475
73TLK10.79082237
74LATS20.78353558
75ATM0.78110499
76CDK80.75711343
77CDK60.74849456
78KDR0.74700778
79MATK0.74282509
80LIMK10.72900552
81TRIB30.71591150
82MELK0.71356832
83MARK30.70317325
84CDK90.68841772
85CSNK2A20.68820185
86PAK10.66618316
87MTOR0.62955747
88CHUK0.61398999
89RIPK40.61334674
90MAP3K30.59062473
91CDK11A0.58762294
92STK38L0.58654498
93BMX0.57629031
94MAP2K20.57251356
95CDK10.56528226
96NME10.55847711
97ZAP700.55550804
98CSNK2A10.54102743
99MAP3K90.53533343
100KSR20.52764139
101MAP3K10.51142526
102PRKCI0.50937676
103BRD40.50812002
104PAK20.50186065
105CDK140.49142307
106BTK0.47134079
107SIK10.46427089
108IRAK20.46014154
109CDK190.45701237
110ILK0.44950581
111MAP2K30.44590842
112CDK150.44556903
113MST40.44502355
114AKT20.43755225
115ZAK0.43356824
116STK240.42482055
117GRK60.41769789
118TXK0.40887050
119CCNB10.40713230
120MAP3K110.40569235
121CDK30.40261924
122CSNK1E0.39907645
123RAF10.39715572
124JAK30.39375685
125CSF1R0.39165978
126DYRK20.37630779
127LATS10.37196014
128RPS6KA50.36253958
129BRAF0.33745654
130PRKDC0.30778441
131EIF2AK20.30716884
132MAP3K50.29861953
133MAPK110.28530061
134MAPKAPK20.27045036
135TYK20.26482011
136PNCK0.26334533
137TAOK20.24957891
138ABL20.24421649

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.71706836
2Mismatch repair_Homo sapiens_hsa034303.82902598
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73399091
4Ribosome_Homo sapiens_hsa030103.43666108
5* Spliceosome_Homo sapiens_hsa030403.38052995
6RNA transport_Homo sapiens_hsa030133.21837103
7RNA polymerase_Homo sapiens_hsa030203.05145910
8Proteasome_Homo sapiens_hsa030502.86411352
9Cell cycle_Homo sapiens_hsa041102.80637653
10Base excision repair_Homo sapiens_hsa034102.74858075
11Nucleotide excision repair_Homo sapiens_hsa034202.73058060
12One carbon pool by folate_Homo sapiens_hsa006702.72600232
13Homologous recombination_Homo sapiens_hsa034402.58134066
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51796750
15Pyrimidine metabolism_Homo sapiens_hsa002402.35407764
16Non-homologous end-joining_Homo sapiens_hsa034501.85674380
17p53 signaling pathway_Homo sapiens_hsa041151.85088489
18RNA degradation_Homo sapiens_hsa030181.84996543
19Basal transcription factors_Homo sapiens_hsa030221.80915463
20mRNA surveillance pathway_Homo sapiens_hsa030151.74434215
21Fanconi anemia pathway_Homo sapiens_hsa034601.74326233
22Epstein-Barr virus infection_Homo sapiens_hsa051691.31161693
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29329569
24Antigen processing and presentation_Homo sapiens_hsa046121.20047846
25Folate biosynthesis_Homo sapiens_hsa007901.13440826
26T cell receptor signaling pathway_Homo sapiens_hsa046601.12763978
27Viral carcinogenesis_Homo sapiens_hsa052031.11106377
28TNF signaling pathway_Homo sapiens_hsa046681.11104605
29Purine metabolism_Homo sapiens_hsa002301.08092983
30Herpes simplex infection_Homo sapiens_hsa051681.06926733
31Osteoclast differentiation_Homo sapiens_hsa043801.06397281
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05819935
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05398120
34Systemic lupus erythematosus_Homo sapiens_hsa053221.03427620
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03334063
36Asthma_Homo sapiens_hsa053100.98982915
37Pentose phosphate pathway_Homo sapiens_hsa000300.96886107
38Selenocompound metabolism_Homo sapiens_hsa004500.94300312
39Biosynthesis of amino acids_Homo sapiens_hsa012300.93167970
40Allograft rejection_Homo sapiens_hsa053300.91471071
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90924209
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.90443191
43Thyroid cancer_Homo sapiens_hsa052160.89267173
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.88120452
45Graft-versus-host disease_Homo sapiens_hsa053320.85305666
46HTLV-I infection_Homo sapiens_hsa051660.84408256
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84098724
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80263514
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79693687
50Small cell lung cancer_Homo sapiens_hsa052220.79087996
51Oocyte meiosis_Homo sapiens_hsa041140.78758377
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78326102
53MicroRNAs in cancer_Homo sapiens_hsa052060.78285070
54Other glycan degradation_Homo sapiens_hsa005110.76142683
55Legionellosis_Homo sapiens_hsa051340.76058737
56VEGF signaling pathway_Homo sapiens_hsa043700.70488012
57Vitamin B6 metabolism_Homo sapiens_hsa007500.69974111
58Sulfur relay system_Homo sapiens_hsa041220.69014931
59Salmonella infection_Homo sapiens_hsa051320.65790568
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64809380
61Hepatitis C_Homo sapiens_hsa051600.64559460
62Apoptosis_Homo sapiens_hsa042100.63216460
63Toxoplasmosis_Homo sapiens_hsa051450.62065939
64Protein export_Homo sapiens_hsa030600.61817874
65Chronic myeloid leukemia_Homo sapiens_hsa052200.61740557
66Primary immunodeficiency_Homo sapiens_hsa053400.61674138
67Prion diseases_Homo sapiens_hsa050200.61583989
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59710632
69Autoimmune thyroid disease_Homo sapiens_hsa053200.59709782
70Renal cell carcinoma_Homo sapiens_hsa052110.57260905
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.57086971
72Tuberculosis_Homo sapiens_hsa051520.56737157
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56558162
74Shigellosis_Homo sapiens_hsa051310.56121851
75Pertussis_Homo sapiens_hsa051330.55695599
76Bladder cancer_Homo sapiens_hsa052190.52520176
77Colorectal cancer_Homo sapiens_hsa052100.52121943
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51335739
79Measles_Homo sapiens_hsa051620.50791353
80Prolactin signaling pathway_Homo sapiens_hsa049170.50772573
81N-Glycan biosynthesis_Homo sapiens_hsa005100.49445492
82Hepatitis B_Homo sapiens_hsa051610.49427163
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.48078628
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.47409393
85Viral myocarditis_Homo sapiens_hsa054160.46056285
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45887417
87Huntingtons disease_Homo sapiens_hsa050160.45176612
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44921202
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44005502
90Hippo signaling pathway_Homo sapiens_hsa043900.43062533
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42750565
92TGF-beta signaling pathway_Homo sapiens_hsa043500.42515173
93Carbon metabolism_Homo sapiens_hsa012000.42189883
94Notch signaling pathway_Homo sapiens_hsa043300.42016908
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41569475
96Endometrial cancer_Homo sapiens_hsa052130.40348798
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39588476
98Acute myeloid leukemia_Homo sapiens_hsa052210.38639672
99mTOR signaling pathway_Homo sapiens_hsa041500.38574523
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37991883
101Parkinsons disease_Homo sapiens_hsa050120.37890849
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37811832
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.37744403
104Malaria_Homo sapiens_hsa051440.37590344
105Glutathione metabolism_Homo sapiens_hsa004800.35791435
106Influenza A_Homo sapiens_hsa051640.32995394
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31305994
108HIF-1 signaling pathway_Homo sapiens_hsa040660.29764803
109Adherens junction_Homo sapiens_hsa045200.29341750
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28186372
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27615413
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27314518
113Fructose and mannose metabolism_Homo sapiens_hsa000510.26972147
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.26144475
115Pathways in cancer_Homo sapiens_hsa052000.26113320
116Pancreatic cancer_Homo sapiens_hsa052120.25800696
117Basal cell carcinoma_Homo sapiens_hsa052170.23795174
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22597422
119Alcoholism_Homo sapiens_hsa050340.22136608
120Prostate cancer_Homo sapiens_hsa052150.21635965
121Hematopoietic cell lineage_Homo sapiens_hsa046400.21417700
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21180123
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20154663
124B cell receptor signaling pathway_Homo sapiens_hsa046620.19237731
125Proteoglycans in cancer_Homo sapiens_hsa052050.18848794
126Non-small cell lung cancer_Homo sapiens_hsa052230.18331010
127Leishmaniasis_Homo sapiens_hsa051400.17033892
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16371598
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.15457542
130Lysine degradation_Homo sapiens_hsa003100.14933488
131Galactose metabolism_Homo sapiens_hsa000520.13774906
132FoxO signaling pathway_Homo sapiens_hsa040680.13276423

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