RBM17P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)8.99185815
2detection of light stimulus involved in visual perception (GO:0050908)8.99185815
3Peyers patch development (GO:0048541)8.17154884
4mucosal-associated lymphoid tissue development (GO:0048537)8.17154884
5regulation of voltage-gated calcium channel activity (GO:1901385)7.40136255
6regulation of chromatin binding (GO:0035561)5.95281587
7behavioral response to ethanol (GO:0048149)5.86563488
8cornea development in camera-type eye (GO:0061303)5.64936340
9protein-chromophore linkage (GO:0018298)5.60175383
10somite development (GO:0061053)5.32227133
11positive regulation of inositol phosphate biosynthetic process (GO:0060732)5.24391161
12phosphatidylserine acyl-chain remodeling (GO:0036150)4.91945436
13regulation of inositol phosphate biosynthetic process (GO:0010919)4.59542252
14phosphatidylinositol acyl-chain remodeling (GO:0036149)4.44600435
15seminiferous tubule development (GO:0072520)4.18207750
16skeletal muscle tissue regeneration (GO:0043403)4.11334276
17cellular ketone body metabolic process (GO:0046950)4.05749585
18keratinocyte development (GO:0003334)3.96688286
19positive regulation of mRNA catabolic process (GO:0061014)3.82240994
20mesenchymal-epithelial cell signaling (GO:0060638)3.78523130
21Sertoli cell development (GO:0060009)3.74485817
22phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.72016275
23regulation of non-canonical Wnt signaling pathway (GO:2000050)3.69784743
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68877310
25regulation of mRNA catabolic process (GO:0061013)3.67878625
26serotonin metabolic process (GO:0042428)3.65805998
27histone H4-K12 acetylation (GO:0043983)3.64292887
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64237845
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.64237845
30regulation of translation, ncRNA-mediated (GO:0045974)3.64237845
31thymus development (GO:0048538)3.59549678
32ketone body metabolic process (GO:1902224)3.58817970
33histone-serine phosphorylation (GO:0035404)3.57909346
34regulation of axon guidance (GO:1902667)3.50186871
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49624758
36negative regulation of axon guidance (GO:1902668)3.47593432
37spinal cord association neuron differentiation (GO:0021527)3.42889377
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.41076255
39positive regulation of cAMP-mediated signaling (GO:0043950)3.29883117
40adult walking behavior (GO:0007628)3.28725172
41cAMP metabolic process (GO:0046058)3.28673630
42photoreceptor cell maintenance (GO:0045494)3.28062654
43regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.26093539
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.26093539
45regulation of cellular senescence (GO:2000772)3.23876211
46behavioral response to nicotine (GO:0035095)3.22317357
47regulation of histone phosphorylation (GO:0033127)3.20098758
48striated muscle atrophy (GO:0014891)3.19332826
49phosphatidylcholine acyl-chain remodeling (GO:0036151)3.18312872
50primary amino compound metabolic process (GO:1901160)3.16629718
51neuronal action potential (GO:0019228)3.05184452
52uterus development (GO:0060065)3.02968635
53muscle atrophy (GO:0014889)3.02668319
54calcium-mediated signaling using intracellular calcium source (GO:0035584)2.98795404
55interkinetic nuclear migration (GO:0022027)2.95392424
56NLS-bearing protein import into nucleus (GO:0006607)2.90885883
57regulation of phospholipid biosynthetic process (GO:0071071)2.89933889
58sodium-independent organic anion transport (GO:0043252)2.89743803
59positive regulation of DNA-templated transcription, initiation (GO:2000144)2.89370325
60positive regulation of mRNA metabolic process (GO:1903313)2.88424446
61DNA replication-dependent nucleosome assembly (GO:0006335)2.87492516
62DNA replication-dependent nucleosome organization (GO:0034723)2.87492516
63spinal cord motor neuron differentiation (GO:0021522)2.86992848
64regulation of axon extension involved in axon guidance (GO:0048841)2.84421130
65skeletal muscle adaptation (GO:0043501)2.84326163
66response to acidic pH (GO:0010447)2.83449422
67regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.81705741
68positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.81705741
69G-protein coupled receptor internalization (GO:0002031)2.80341539
70regulation of gene silencing by RNA (GO:0060966)2.75143464
71regulation of posttranscriptional gene silencing (GO:0060147)2.75143464
72regulation of gene silencing by miRNA (GO:0060964)2.75143464
73neuromuscular junction development (GO:0007528)2.72930867
74cytoplasmic mRNA processing body assembly (GO:0033962)2.69030706
75ventricular septum development (GO:0003281)2.68883162
76determination of adult lifespan (GO:0008340)2.68809010
77regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.67447989
78regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.67447989
79phospholipid catabolic process (GO:0009395)2.67313560
80behavioral response to cocaine (GO:0048148)2.65268939
81activated T cell proliferation (GO:0050798)2.64687013
82adipose tissue development (GO:0060612)2.64389920
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63524724
84regulation of neurotransmitter uptake (GO:0051580)2.63086434
85regulation of DNA endoreduplication (GO:0032875)2.59075454
86synaptic transmission, glutamatergic (GO:0035249)2.58322620
87neural tube formation (GO:0001841)2.56305973
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55939103
89muscle fiber development (GO:0048747)2.55424728
90Golgi to endosome transport (GO:0006895)2.51897440
91regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.48854010
92cardiac septum development (GO:0003279)2.48157928
93positive regulation of mRNA 3-end processing (GO:0031442)2.48010051
94male meiosis (GO:0007140)2.47770582
95detection of molecule of bacterial origin (GO:0032490)2.46582089
96detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.46476708
97positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44250486
98endosome to melanosome transport (GO:0035646)2.44068364
99neuronal action potential propagation (GO:0019227)12.3336422
100gamma-aminobutyric acid transport (GO:0015812)10.6252484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.22882102
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.79052546
3ZNF274_21170338_ChIP-Seq_K562_Hela3.07583840
4TAF15_26573619_Chip-Seq_HEK293_Human3.05535968
5VDR_22108803_ChIP-Seq_LS180_Human2.94767611
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.58832969
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58786319
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56242948
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37410068
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36455610
11GBX2_23144817_ChIP-Seq_PC3_Human2.32186163
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25648097
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25357230
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20249535
15EWS_26573619_Chip-Seq_HEK293_Human2.18364072
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13567317
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00749068
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96248419
19BCAT_22108803_ChIP-Seq_LS180_Human1.93211905
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92120398
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89457474
22ER_23166858_ChIP-Seq_MCF-7_Human1.85130235
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.81852950
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76454411
25TP53_16413492_ChIP-PET_HCT116_Human1.72908524
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71583256
27STAT3_23295773_ChIP-Seq_U87_Human1.67672100
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65543294
29GATA1_22025678_ChIP-Seq_K562_Human1.62892634
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62328897
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60187310
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59182211
33RUNX2_22187159_ChIP-Seq_PCA_Human1.57618585
34AR_25329375_ChIP-Seq_VCAP_Human1.56779342
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56216200
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56216200
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54514913
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.50817989
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44660487
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42975346
41RNF2_27304074_Chip-Seq_NSC_Mouse1.42765438
42P300_19829295_ChIP-Seq_ESCs_Human1.41822622
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.40658831
44HTT_18923047_ChIP-ChIP_STHdh_Human1.36729288
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36343544
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.35741841
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34936373
48SMAD4_21799915_ChIP-Seq_A2780_Human1.33898363
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30779945
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28647531
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.27066518
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.26788915
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.26248408
54REST_21632747_ChIP-Seq_MESCs_Mouse1.23528662
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21267846
56KDM2B_26808549_Chip-Seq_REH_Human1.19751726
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18475362
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.17432521
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17393493
60LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16753062
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16512058
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.14780437
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.14278425
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12666747
65IGF1R_20145208_ChIP-Seq_DFB_Human1.11465682
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.11189515
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10067492
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09928290
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08574423
70TCF4_23295773_ChIP-Seq_U87_Human1.06500867
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.06117139
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05069980
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.04853559
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04394748
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.04394748
76SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03973395
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.03769806
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03416900
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02250089
80JUN_21703547_ChIP-Seq_K562_Human1.02040729
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01473880
82CBP_20019798_ChIP-Seq_JUKART_Human1.01062139
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01062139
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00985005
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99296714
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.99175470
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98583419
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96474270
89OCT1_27270436_Chip-Seq_PROSTATE_Human0.96165986
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.96143898
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95184825
92DROSHA_22980978_ChIP-Seq_HELA_Human0.94437853
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.94166250
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93900224
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93342678
96RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93342678
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92738061
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92502931
99IRF1_19129219_ChIP-ChIP_H3396_Human0.92341456
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91716236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.34331826
2MP0000569_abnormal_digit_pigmentation4.19955186
3MP0003880_abnormal_central_pattern4.05911233
4MP0000372_irregular_coat_pigmentation3.65847474
5MP0002102_abnormal_ear_morphology3.36662962
6MP0008057_abnormal_DNA_replication3.16756581
7MP0000631_abnormal_neuroendocrine_gland3.01808831
8MP0005645_abnormal_hypothalamus_physiol3.01516926
9MP0003195_calcinosis2.78907366
10MP0005423_abnormal_somatic_nervous2.76820212
11MP0008877_abnormal_DNA_methylation2.59936401
12MP0003315_abnormal_perineum_morphology2.55836025
13MP0002938_white_spotting2.37907855
14MP0003724_increased_susceptibility_to2.33484915
15MP0009745_abnormal_behavioral_response2.28151604
16MP0005671_abnormal_response_to2.22220348
17MP0005187_abnormal_penis_morphology2.12169740
18MP0005551_abnormal_eye_electrophysiolog2.10726984
19MP0001542_abnormal_bone_strength1.92842471
20MP0009046_muscle_twitch1.91089377
21MP0005647_abnormal_sex_gland1.90104726
22MP0003938_abnormal_ear_development1.88701233
23MP0005389_reproductive_system_phenotype1.77264881
24MP0003866_abnormal_defecation1.76668145
25MP0001919_abnormal_reproductive_system1.66363691
26MP0001545_abnormal_hematopoietic_system1.65326493
27MP0005397_hematopoietic_system_phenotyp1.65326493
28MP0002272_abnormal_nervous_system1.55676452
29MP0004147_increased_porphyrin_level1.52895491
30MP0003890_abnormal_embryonic-extraembry1.50906251
31MP0001486_abnormal_startle_reflex1.49017712
32MP0003119_abnormal_digestive_system1.46661250
33MP0002736_abnormal_nociception_after1.42383227
34MP0002572_abnormal_emotion/affect_behav1.40473765
35MP0004742_abnormal_vestibular_system1.39144663
36MP0004924_abnormal_behavior1.38459150
37MP0005386_behavior/neurological_phenoty1.38459150
38MP0002277_abnormal_respiratory_mucosa1.34669190
39MP0003878_abnormal_ear_physiology1.34051196
40MP0005377_hearing/vestibular/ear_phenot1.34051196
41MP0001968_abnormal_touch/_nociception1.33879149
42MP0008789_abnormal_olfactory_epithelium1.28135732
43MP0003937_abnormal_limbs/digits/tail_de1.26920075
44MP0002734_abnormal_mechanical_nocicepti1.25743248
45MP0009840_abnormal_foam_cell1.24941118
46MP0002067_abnormal_sensory_capabilities1.24820468
47MP0002160_abnormal_reproductive_system1.20719153
48MP0005408_hypopigmentation1.20341842
49MP0002932_abnormal_joint_morphology1.19684169
50MP0003959_abnormal_lean_body1.17491832
51MP0008875_abnormal_xenobiotic_pharmacok1.17001244
52MP0005174_abnormal_tail_pigmentation1.16037469
53MP0000750_abnormal_muscle_regeneration1.13061888
54MP0002733_abnormal_thermal_nociception1.09173534
55MP0002138_abnormal_hepatobiliary_system1.03561400
56MP0003950_abnormal_plasma_membrane1.03559820
57MP0008961_abnormal_basal_metabolism1.01904564
58MP0001293_anophthalmia1.01652788
59MP0004484_altered_response_of1.00098893
60MP0003828_pulmonary_edema0.98521631
61MP0003221_abnormal_cardiomyocyte_apopto0.96963316
62MP0002064_seizures0.95160471
63MP0001970_abnormal_pain_threshold0.94214228
64MP0009764_decreased_sensitivity_to0.93705426
65MP0003787_abnormal_imprinting0.93089911
66MP0003635_abnormal_synaptic_transmissio0.91677614
67MP0002109_abnormal_limb_morphology0.91472129
68MP0001119_abnormal_female_reproductive0.88190999
69MP0005266_abnormal_metabolism0.86684137
70MP0003698_abnormal_male_reproductive0.84892068
71MP0002152_abnormal_brain_morphology0.84536359
72MP0000427_abnormal_hair_cycle0.84258106
73MP0002752_abnormal_somatic_nervous0.83498827
74MP0002557_abnormal_social/conspecific_i0.83440915
75MP0002735_abnormal_chemical_nociception0.83092911
76MP0002822_catalepsy0.82731824
77MP0000639_abnormal_adrenal_gland0.78661241
78MP0002234_abnormal_pharynx_morphology0.77778869
79MP0001440_abnormal_grooming_behavior0.77748059
80MP0004270_analgesia0.77021700
81MP0003121_genomic_imprinting0.76994067
82MP0000003_abnormal_adipose_tissue0.75010795
83MP0005394_taste/olfaction_phenotype0.72715453
84MP0005499_abnormal_olfactory_system0.72715453
85MP0004885_abnormal_endolymph0.69675718
86MP0001929_abnormal_gametogenesis0.69578937
87MP0000653_abnormal_sex_gland0.69129783
88MP0001324_abnormal_eye_pigmentation0.68008373
89MP0003693_abnormal_embryo_hatching0.67845628
90MP0003303_peritoneal_inflammation0.67603684
91MP0003935_abnormal_craniofacial_develop0.65390503
92MP0001485_abnormal_pinna_reflex0.64698882
93MP0005167_abnormal_blood-brain_barrier0.63957932
94MP0001286_abnormal_eye_development0.61968947
95MP0003115_abnormal_respiratory_system0.59828119
96MP0000955_abnormal_spinal_cord0.58845746
97MP0003646_muscle_fatigue0.58179360
98MP0003638_abnormal_response/metabolism_0.58030015
99MP0010030_abnormal_orbit_morphology0.57890504
100MP0003045_fibrosis0.57428976

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)9.64337198
2Hyperventilation (HP:0002883)5.84231541
3Gaze-evoked nystagmus (HP:0000640)5.54965918
4Tinnitus (HP:0000360)5.14962783
5Abnormality of dentin (HP:0010299)4.37425143
6Gonadotropin excess (HP:0000837)4.34781390
7Tubular atrophy (HP:0000092)4.32758310
8Inappropriate behavior (HP:0000719)4.30542261
9Febrile seizures (HP:0002373)3.99784226
10Acanthocytosis (HP:0001927)3.79349455
11Tubulointerstitial fibrosis (HP:0005576)3.71230404
12Enlarged penis (HP:0000040)3.68532184
13Atonic seizures (HP:0010819)3.64506343
14Dyskinesia (HP:0100660)3.38586355
15Polydipsia (HP:0001959)3.35751761
16Abnormal drinking behavior (HP:0030082)3.35751761
17Small hand (HP:0200055)3.32569477
18Protruding tongue (HP:0010808)3.28433767
19Drooling (HP:0002307)3.22313356
20Abnormality of midbrain morphology (HP:0002418)3.19921564
21Molar tooth sign on MRI (HP:0002419)3.19921564
22Fair hair (HP:0002286)3.15675391
23Birth length less than 3rd percentile (HP:0003561)3.08810423
24Acute lymphatic leukemia (HP:0006721)3.07826375
25Excessive salivation (HP:0003781)3.05805201
26Generalized myoclonic seizures (HP:0002123)3.05352506
27Disinhibition (HP:0000734)3.03628613
28Type 2 muscle fiber atrophy (HP:0003554)3.03359594
29Nephronophthisis (HP:0000090)2.87508325
30Curly hair (HP:0002212)2.74665949
31Abnormality of the renal cortex (HP:0011035)2.70885440
32Abnormality of the dental pulp (HP:0006479)2.69954665
33Absent speech (HP:0001344)2.68829742
34Abnormality of the renal medulla (HP:0100957)2.66476180
35Polyuria (HP:0000103)2.61449383
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.58640587
37Absent/shortened dynein arms (HP:0200106)2.58640587
38Focal seizures (HP:0007359)2.57895069
39Tubulointerstitial abnormality (HP:0001969)2.52267835
40Pancreatic cysts (HP:0001737)2.49586222
41Concave nail (HP:0001598)2.46996566
42Flat occiput (HP:0005469)2.45355745
43Thickened helices (HP:0000391)2.44515315
44Broad-based gait (HP:0002136)2.43795422
45Choroideremia (HP:0001139)2.43251065
46Muscle fiber atrophy (HP:0100295)2.40296813
47Abnormality of the ileum (HP:0001549)2.34164374
48Acute hepatic failure (HP:0006554)2.29306055
49Hypoplastic pelvis (HP:0008839)2.29107860
50Generalized hypopigmentation of hair (HP:0011358)2.28918626
51Medial flaring of the eyebrow (HP:0010747)2.23291965
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23247886
53Decreased central vision (HP:0007663)2.22724419
54Attenuation of retinal blood vessels (HP:0007843)2.21873360
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.19305897
56Stereotypic behavior (HP:0000733)2.18433713
57Clumsiness (HP:0002312)2.16809743
58Focal motor seizures (HP:0011153)2.16314928
59Volvulus (HP:0002580)2.14681048
60Asplenia (HP:0001746)2.10185074
61Nonprogressive disorder (HP:0003680)2.09321668
62Bulbous nose (HP:0000414)2.08092582
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.07686483
64Optic neuritis (HP:0100653)2.05953970
65Retrobulbar optic neuritis (HP:0100654)2.05953970
66Orchitis (HP:0100796)2.04016804
67Meckel diverticulum (HP:0002245)2.03036707
68Abnormality of salivation (HP:0100755)2.02828504
69Abnormal urine output (HP:0012590)2.02780282
70Hemiparesis (HP:0001269)2.00977983
71Abnormality of placental membranes (HP:0011409)1.99368868
72Amniotic constriction ring (HP:0009775)1.99368868
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.96973395
74Severe muscular hypotonia (HP:0006829)1.94444697
75Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92225486
76Genital tract atresia (HP:0001827)1.89852247
77Aplasia cutis congenita (HP:0001057)1.88693064
78Widely spaced teeth (HP:0000687)1.88662830
79Partial agenesis of the corpus callosum (HP:0001338)1.88152698
80Supernumerary spleens (HP:0009799)1.85954918
81Vaginal atresia (HP:0000148)1.84852568
82Inability to walk (HP:0002540)1.82626417
83Exotropia (HP:0000577)1.81108381
84Pancreatic fibrosis (HP:0100732)1.80581380
85Midline defect of the nose (HP:0004122)1.78585424
86Abnormality of the neuromuscular junction (HP:0003398)1.77530010
87Fatigable weakness (HP:0003473)1.77530010
88Abnormality of renal excretion (HP:0011036)1.77274793
89Self-mutilation (HP:0000742)1.77163079
90Abnormality of the carotid arteries (HP:0005344)1.76829810
91Cystic hygroma (HP:0000476)1.76132986
92Abnormality of the preputium (HP:0100587)1.73655930
93Absence seizures (HP:0002121)1.71267598
94Osteomalacia (HP:0002749)1.70835054
95Palpebral edema (HP:0100540)1.70624220
96Septo-optic dysplasia (HP:0100842)1.69970341
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63403798
98Status epilepticus (HP:0002133)1.63299098
99Aplasia of the musculature (HP:0100854)1.62633691
100Patellar aplasia (HP:0006443)1.59889700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.67162021
2MAP3K64.42854167
3MAP3K94.32193177
4ACVR1B4.19741674
5TNIK3.71020799
6MKNK23.31717244
7MUSK2.94263682
8BRSK22.89329871
9CASK2.87080097
10PTK2B2.55284266
11MAP2K72.46430145
12BMPR1B2.03297020
13FRK1.96995055
14PLK41.83365350
15MKNK11.83067602
16MAP2K41.78858699
17WNK31.66044976
18KSR21.63614505
19BRAF1.61972029
20IRAK11.60021944
21EPHA41.58260904
22SIK21.49690208
23DYRK31.48102854
24RAF11.46684489
25ERN11.42413312
26NTRK21.41534601
27NUAK11.40432264
28MARK31.33223370
29MARK11.13929457
30ADRBK11.12893071
31ARAF1.11912655
32INSRR1.02718012
33AKT31.02276613
34SGK20.97336149
35TGFBR10.90573835
36NEK20.90377695
37IRAK40.88461046
38NLK0.87094890
39MAP3K50.86416695
40MAP3K130.84132717
41PKN10.82257238
42GRK10.81710814
43WNK40.78749029
44ERBB30.78108792
45PIK3CA0.77866216
46TLK10.76780553
47MAPK130.75969451
48ADRBK20.74836158
49MAP2K10.74349375
50PAK30.71386847
51OXSR10.70675539
52MAP2K30.69523125
53WNK10.67129009
54PRKCQ0.64230372
55STK30.60778350
56TAF10.60471571
57RPS6KA40.59454598
58PRKCG0.58679725
59STK380.55997666
60TNK20.55064725
61CHEK20.53692391
62TGFBR20.53260680
63PRKAA20.52542060
64SGK2230.52465729
65SGK4940.52465729
66DYRK1A0.51396501
67NEK90.51356627
68MOS0.49636447
69RET0.48562253
70BRSK10.48463917
71KSR10.46348577
72PLK30.46030483
73SGK30.46003564
74CAMK1D0.44909220
75STK110.43287675
76TAOK10.40812875
77STK390.39940463
78FGR0.36347540
79FGFR10.34774517
80MAP4K20.33451096
81PRKCE0.33325033
82MAP3K20.30216310
83CSNK1D0.30144525
84PLK10.29386154
85LYN0.28985488
86RPS6KA50.28626409
87PAK60.28416637
88MINK10.27750952
89MELK0.27635287
90BLK0.26984611
91DMPK0.26234623
92VRK10.26067473
93IRAK20.25191024
94DYRK20.25097721
95CAMK40.23420493
96STK38L0.23321995
97CAMK2A0.23018558
98STK100.21896233
99MAP3K80.20636306
100STK240.20077295

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.25361744
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.13973003
3Linoleic acid metabolism_Homo sapiens_hsa005913.59653076
4Ether lipid metabolism_Homo sapiens_hsa005652.71252494
5Ovarian steroidogenesis_Homo sapiens_hsa049132.56150184
6Olfactory transduction_Homo sapiens_hsa047402.37149541
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.13996104
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01384039
9Nitrogen metabolism_Homo sapiens_hsa009102.00048538
10Arachidonic acid metabolism_Homo sapiens_hsa005901.94623914
11Homologous recombination_Homo sapiens_hsa034401.86538418
12Dorso-ventral axis formation_Homo sapiens_hsa043201.84334416
13Basal cell carcinoma_Homo sapiens_hsa052171.83615438
14Hedgehog signaling pathway_Homo sapiens_hsa043401.78880076
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71501907
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69302832
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67570042
18Long-term depression_Homo sapiens_hsa047301.46491323
19Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44595259
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37873595
21Glutamatergic synapse_Homo sapiens_hsa047241.33875777
22Serotonergic synapse_Homo sapiens_hsa047261.33694299
23GnRH signaling pathway_Homo sapiens_hsa049121.26733287
24Choline metabolism in cancer_Homo sapiens_hsa052311.21615141
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20919071
26Oxytocin signaling pathway_Homo sapiens_hsa049211.18772797
27MAPK signaling pathway_Homo sapiens_hsa040101.18409606
28Nicotine addiction_Homo sapiens_hsa050331.17597507
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15828388
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15746712
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15624854
32Butanoate metabolism_Homo sapiens_hsa006501.14541742
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.14064621
34Melanogenesis_Homo sapiens_hsa049161.11355455
35Cocaine addiction_Homo sapiens_hsa050301.08241827
36Taste transduction_Homo sapiens_hsa047421.07476080
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06460982
38Prolactin signaling pathway_Homo sapiens_hsa049171.05508685
39TNF signaling pathway_Homo sapiens_hsa046681.04999542
40Fatty acid biosynthesis_Homo sapiens_hsa000610.94905203
41Fanconi anemia pathway_Homo sapiens_hsa034600.94031877
42Basal transcription factors_Homo sapiens_hsa030220.92641507
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90036446
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.88181383
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88101363
46cAMP signaling pathway_Homo sapiens_hsa040240.87752883
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86051773
48VEGF signaling pathway_Homo sapiens_hsa043700.84339702
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82394781
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.80398202
51Inositol phosphate metabolism_Homo sapiens_hsa005620.78628589
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77255019
53Calcium signaling pathway_Homo sapiens_hsa040200.76733158
54Non-homologous end-joining_Homo sapiens_hsa034500.75931212
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75874145
56Melanoma_Homo sapiens_hsa052180.74857456
57Hippo signaling pathway_Homo sapiens_hsa043900.73971832
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73214540
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73132226
60Dilated cardiomyopathy_Homo sapiens_hsa054140.71290523
61Wnt signaling pathway_Homo sapiens_hsa043100.65553071
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64776311
63TGF-beta signaling pathway_Homo sapiens_hsa043500.64327497
64Starch and sucrose metabolism_Homo sapiens_hsa005000.63687788
65Morphine addiction_Homo sapiens_hsa050320.62787119
66Phototransduction_Homo sapiens_hsa047440.62634926
67Dopaminergic synapse_Homo sapiens_hsa047280.60788771
68FoxO signaling pathway_Homo sapiens_hsa040680.58786385
69Platelet activation_Homo sapiens_hsa046110.57192976
70Gastric acid secretion_Homo sapiens_hsa049710.57156363
71Axon guidance_Homo sapiens_hsa043600.56661402
72Cardiac muscle contraction_Homo sapiens_hsa042600.55933032
73Gap junction_Homo sapiens_hsa045400.55612478
74Sphingolipid metabolism_Homo sapiens_hsa006000.54077729
75Amphetamine addiction_Homo sapiens_hsa050310.52924218
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50695779
77Rap1 signaling pathway_Homo sapiens_hsa040150.50614332
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.50209612
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.49227366
80Ras signaling pathway_Homo sapiens_hsa040140.48794173
81Estrogen signaling pathway_Homo sapiens_hsa049150.47598759
82Glycerolipid metabolism_Homo sapiens_hsa005610.46836467
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45713647
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43181741
85Legionellosis_Homo sapiens_hsa051340.42111151
86Peroxisome_Homo sapiens_hsa041460.39943606
87Alcoholism_Homo sapiens_hsa050340.39607737
88Type II diabetes mellitus_Homo sapiens_hsa049300.38816739
89Bladder cancer_Homo sapiens_hsa052190.37598552
90RNA degradation_Homo sapiens_hsa030180.36429486
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36399890
92Nucleotide excision repair_Homo sapiens_hsa034200.35096327
93Staphylococcus aureus infection_Homo sapiens_hsa051500.35016885
94Malaria_Homo sapiens_hsa051440.34828575
95Pathways in cancer_Homo sapiens_hsa052000.34813673
96Osteoclast differentiation_Homo sapiens_hsa043800.34295383
97Prostate cancer_Homo sapiens_hsa052150.33617285
98Circadian entrainment_Homo sapiens_hsa047130.32033532
99B cell receptor signaling pathway_Homo sapiens_hsa046620.31790730
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30562742

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