ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.19136705
2	lipopolysaccharide biosynthetic process (GO:0009103)	8.84007937
3	protein-chromophore linkage (GO:0018298)	8.72428667
4	DNA methylation involved in gamete generation (GO:0043046)	8.33909578
5	regulation of meiosis I (GO:0060631)	7.90013630
6	lipopolysaccharide metabolic process (GO:0008653)	7.68316076
7	regulation of pigment cell differentiation (GO:0050932)	7.58676797
8	regulation of protein glycosylation (GO:0060049)	7.47197877
9	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.45306982
10	positive regulation of developmental pigmentation (GO:0048087)	7.17924167
11	negative regulation of glycoprotein biosynthetic process (GO:0010561)	6.91625269
12	paraxial mesoderm development (GO:0048339)	6.91320590
13	sulfate transmembrane transport (GO:1902358)	6.83026830
14	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.73717278
15	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.55193947
16	piRNA metabolic process (GO:0034587)	6.00137874
17	SMAD protein complex assembly (GO:0007183)	5.84289612
18	sulfate transport (GO:0008272)	5.80229437
19	notochord development (GO:0030903)	5.75942431
20	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.42979483
21	L-phenylalanine catabolic process (GO:0006559)	5.42979483
22	tyrosine metabolic process (GO:0006570)	5.19817409
23	negative regulation of glycoprotein metabolic process (GO:1903019)	5.12612509
24	heme transport (GO:0015886)	5.07575332
25	meiotic chromosome segregation (GO:0045132)	4.84462426
26	centriole replication (GO:0007099)	4.79347580
27	nodal signaling pathway (GO:0038092)	4.69545112
28	L-phenylalanine metabolic process (GO:0006558)	4.56183383
29	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.56183383
30	negative regulation of stem cell proliferation (GO:2000647)	4.55157290
31	positive regulation of meiosis (GO:0045836)	4.48920359
32	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.46106255
33	ribonucleoprotein complex disassembly (GO:0032988)	4.36927636
34	response to epinephrine (GO:0071871)	4.36076541
35	regulation of transforming growth factor beta2 production (GO:0032909)	4.32841754
36	serotonin receptor signaling pathway (GO:0007210)	4.31003508
37	positive regulation of meiotic cell cycle (GO:0051446)	4.14805421
38	vitamin transmembrane transport (GO:0035461)	4.14581631
39	regulation of interleukin-5 production (GO:0032674)	4.11655549
40	regulation of odontogenesis (GO:0042481)	4.08306358
41	germinal center formation (GO:0002467)	3.99026624
42	tachykinin receptor signaling pathway (GO:0007217)	3.97486418
43	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.93025998
44	glycerol metabolic process (GO:0006071)	3.84213709
45	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.79896017
46	flavonoid metabolic process (GO:0009812)	3.77902479
47	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.75626260
48	negative regulation of cell-matrix adhesion (GO:0001953)	3.70797248
49	DNA damage induced protein phosphorylation (GO:0006975)	3.70477229
50	response to mercury ion (GO:0046689)	3.69247807
51	cellular response to gamma radiation (GO:0071480)	3.68439822
52	sympathetic nervous system development (GO:0048485)	3.65357334
53	iron coordination entity transport (GO:1901678)	3.56489116
54	pantothenate metabolic process (GO:0015939)	3.55907718
55	regulation of developmental pigmentation (GO:0048070)	3.52134498
56	heart valve formation (GO:0003188)	3.47891753
57	organelle disassembly (GO:1903008)	3.47552858
58	aromatic amino acid family catabolic process (GO:0009074)	3.45747226
59	toxin metabolic process (GO:0009404)	3.44207730
60	rhodopsin mediated signaling pathway (GO:0016056)	3.42388281
61	aspartate family amino acid catabolic process (GO:0009068)	3.42189757
62	regulation of keratinocyte proliferation (GO:0010837)	3.37738233
63	alditol metabolic process (GO:0019400)	3.32143769
64	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.32037856
65	organ induction (GO:0001759)	3.28796410
66	uterus development (GO:0060065)	3.28148353
67	positive regulation of vascular permeability (GO:0043117)	3.27116713
68	sulfur compound transport (GO:0072348)	3.23880513
69	negative regulation of neural precursor cell proliferation (GO:2000178)	3.23413776
70	biotin metabolic process (GO:0006768)	3.19793103
71	somite rostral/caudal axis specification (GO:0032525)	3.19000022
72	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.18576754
73	lysine metabolic process (GO:0006553)	3.14516427
74	lysine catabolic process (GO:0006554)	3.14516427
75	centriole assembly (GO:0098534)	3.12653782
76	polyol biosynthetic process (GO:0046173)	3.12054477
77	urate metabolic process (GO:0046415)	3.04714965
78	protein retention in ER lumen (GO:0006621)	3.03613147
79	aromatic amino acid family metabolic process (GO:0009072)	3.00579540
80	inflammatory response to antigenic stimulus (GO:0002437)	2.98257821
81	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.97186010
82	regulation of translational termination (GO:0006449)	2.95812355
83	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.93200978
84	embryonic process involved in female pregnancy (GO:0060136)	2.90242491
85	regulation of SMAD protein import into nucleus (GO:0060390)	2.88617053
86	negative regulation of BMP signaling pathway (GO:0030514)	2.88196613
87	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.87733733
88	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.84610216
89	sphingolipid biosynthetic process (GO:0030148)	2.84111486
90	oogenesis (GO:0048477)	2.83742281
91	membrane lipid biosynthetic process (GO:0046467)	2.83272338
92	regulation of metanephros development (GO:0072215)	2.83215575
93	positive regulation of fatty acid oxidation (GO:0046321)	2.83109759
94	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.82422020
95	DNA alkylation (GO:0006305)	2.75876196
96	DNA methylation (GO:0006306)	2.75876196
97	regulation of hair follicle development (GO:0051797)	2.74594787
98	sphingosine metabolic process (GO:0006670)	16.3594914
99	diol metabolic process (GO:0034311)	14.7211311
100	sphingoid metabolic process (GO:0046519)	13.4038045

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.06467819
2	AR_21572438_ChIP-Seq_LNCaP_Human	4.69721584
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.49880538
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.00493709
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.99144609
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.75856295
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.75841908
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68141676
9	P300_19829295_ChIP-Seq_ESCs_Human	2.26673451
10	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.24543291
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19488067
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19339083
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03883456
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.03337471
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.99161399
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94958772
17	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.92799196
18	EGR1_19032775_ChIP-ChIP_M12_Human	1.89108377
19	VDR_22108803_ChIP-Seq_LS180_Human	1.81011622
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80066059
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79625747
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.74181598
23	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.74176342
24	TCF4_23295773_ChIP-Seq_U87_Human	1.73741696
25	SOX2_19829295_ChIP-Seq_ESCs_Human	1.73028775
26	NANOG_19829295_ChIP-Seq_ESCs_Human	1.73028775
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71114239
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69210160
29	STAT3_23295773_ChIP-Seq_U87_Human	1.67442840
30	HOXB7_26014856_ChIP-Seq_BT474_Human	1.64817703
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62345838
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62345838
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58236813
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57561465
35	AR_25329375_ChIP-Seq_VCAP_Human	1.56534488
36	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.54500983
37	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.54459473
38	TP53_16413492_ChIP-PET_HCT116_Human	1.53328085
39	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.51075274
40	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.49428025
41	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.48301593
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48279059
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45127002
44	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.43744849
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.42696232
46	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.42296243
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42115652
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.40948060
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39252307
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31959383
51	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.31881855
52	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.31073321
53	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.30770371
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28364794
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27242301
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.26985117
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26585422
58	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25315485
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.23547431
60	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.23266032
61	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.21617645
62	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21342658
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21280852
64	AR_19668381_ChIP-Seq_PC3_Human	1.20628153
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19841184
66	FUS_26573619_Chip-Seq_HEK293_Human	1.19832590
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.19119845
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19119845
69	CJUN_26792858_Chip-Seq_BT549_Human	1.17896304
70	STAT1_20625510_ChIP-Seq_HELA_Human	1.16423765
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16414942
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15718916
73	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.15526054
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14095670
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12145603
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10771796
77	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.10283397
78	NCOR_22424771_ChIP-Seq_293T_Human	1.10184708
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.10013477
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09791013
81	OCT4_20526341_ChIP-Seq_ESCs_Human	1.09784727
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09403831
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08985921
84	BCAT_22108803_ChIP-Seq_LS180_Human	1.08136649
85	TAF15_26573619_Chip-Seq_HEK293_Human	1.07637796
86	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.07451780
87	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.06683994
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.04303758
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03882307
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02720011
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02671034
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00646564
93	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.99835571
94	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98699327
95	STAT1_17558387_ChIP-Seq_HELA_Human	0.98585896
96	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.98062153
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97992291
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97011489
99	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.96188344
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95300692

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	8.65305724
2	MP0002837_dystrophic_cardiac_calcinosis	8.47793766
3	MP0005171_absent_coat_pigmentation	7.93353903
4	MP0002653_abnormal_ependyma_morphology	5.22701936
5	MP0003890_abnormal_embryonic-extraembry	4.49292943
6	MP0003045_fibrosis	4.19169397
7	MP0000569_abnormal_digit_pigmentation	4.10285949
8	MP0003646_muscle_fatigue	3.87491134
9	MP0004381_abnormal_hair_follicle	3.35437633
10	MP0003879_abnormal_hair_cell	2.79033576
11	MP0002938_white_spotting	2.48254654
12	MP0005670_abnormal_white_adipose	2.21135349
13	MP0005075_abnormal_melanosome_morpholog	2.04973222
14	MP0002168_other_aberrant_phenotype	2.01869417
15	MP0000749_muscle_degeneration	2.01844801
16	MP0005085_abnormal_gallbladder_physiolo	1.91865817
17	MP0002138_abnormal_hepatobiliary_system	1.84810608
18	MP0003195_calcinosis	1.80032546
19	MP0005174_abnormal_tail_pigmentation	1.79226864
20	MP0002095_abnormal_skin_pigmentation	1.78904100
21	MP0003705_abnormal_hypodermis_morpholog	1.72599455
22	MP0000372_irregular_coat_pigmentation	1.70257629
23	MP0000015_abnormal_ear_pigmentation	1.59269537
24	MP0010352_gastrointestinal_tract_polyps	1.53821927
25	MP0004147_increased_porphyrin_level	1.43395203
26	MP0002075_abnormal_coat/hair_pigmentati	1.37663421
27	MP0005395_other_phenotype	1.21809865
28	MP0004233_abnormal_muscle_weight	1.20542333
29	MP0006054_spinal_hemorrhage	1.06854265
30	MP0005365_abnormal_bile_salt	1.03940645
31	MP0001186_pigmentation_phenotype	0.99032175
32	MP0002735_abnormal_chemical_nociception	0.98643866
33	MP0003137_abnormal_impulse_conducting	0.97708202
34	MP0005330_cardiomyopathy	0.97265057
35	MP0002160_abnormal_reproductive_system	0.96056238
36	MP0003252_abnormal_bile_duct	0.94902623
37	MP0003950_abnormal_plasma_membrane	0.94771346
38	MP0002269_muscular_atrophy	0.93684756
39	MP0001324_abnormal_eye_pigmentation	0.88960649
40	MP0000427_abnormal_hair_cycle	0.80858511
41	MP0001984_abnormal_olfaction	0.80829287
42	MP0001501_abnormal_sleep_pattern	0.76252616
43	MP0005408_hypopigmentation	0.70980748
44	MP0004043_abnormal_pH_regulation	0.69557127
45	MP0002254_reproductive_system_inflammat	0.66996056
46	MP0001486_abnormal_startle_reflex	0.63911603
47	MP0000534_abnormal_ureter_morphology	0.60045516
48	MP0003937_abnormal_limbs/digits/tail_de	0.59934845
49	MP0003878_abnormal_ear_physiology	0.58107064
50	MP0005377_hearing/vestibular/ear_phenot	0.58107064
51	MP0008770_decreased_survivor_rate	0.56425003
52	MP0002876_abnormal_thyroid_physiology	0.54038109
53	MP0001661_extended_life_span	0.53006110
54	MP0002332_abnormal_exercise_endurance	0.52656761
55	MP0002638_abnormal_pupillary_reflex	0.51969069
56	MP0002928_abnormal_bile_duct	0.50448918
57	MP0005319_abnormal_enzyme/_coenzyme	0.50057028
58	MP0002272_abnormal_nervous_system	0.46424262
59	MP0002396_abnormal_hematopoietic_system	0.45826845
60	MP0005551_abnormal_eye_electrophysiolog	0.45479310
61	MP0000371_diluted_coat_color	0.44478698
62	MP0008569_lethality_at_weaning	0.41278462
63	MP0002102_abnormal_ear_morphology	0.40406650
64	MP0004484_altered_response_of	0.39290662
65	MP0002971_abnormal_brown_adipose	0.38657640
66	MP0009046_muscle_twitch	0.38310490
67	MP0003385_abnormal_body_wall	0.37882134
68	MP0003300_gastrointestinal_ulcer	0.37167853
69	MP0005248_abnormal_Harderian_gland	0.35370275
70	MP0004130_abnormal_muscle_cell	0.34677480
71	MP0005646_abnormal_pituitary_gland	0.33984932
72	MP0005389_reproductive_system_phenotype	0.33754778
73	MP0002229_neurodegeneration	0.33738920
74	MP0004272_abnormal_basement_membrane	0.33202454
75	MP0005410_abnormal_fertilization	0.32489702
76	MP0009764_decreased_sensitivity_to	0.32183345
77	MP0009115_abnormal_fat_cell	0.31845380
78	MP0002751_abnormal_autonomic_nervous	0.31483575
79	MP0002277_abnormal_respiratory_mucosa	0.30965387
80	MP0005253_abnormal_eye_physiology	0.30753959
81	MP0001970_abnormal_pain_threshold	0.30712271
82	MP0009745_abnormal_behavioral_response	0.30265134
83	MP0010307_abnormal_tumor_latency	0.29202331
84	MP0004142_abnormal_muscle_tone	0.28134988
85	MP0005076_abnormal_cell_differentiation	0.27870440
86	MP0000377_abnormal_hair_follicle	0.27594075
87	MP0000026_abnormal_inner_ear	0.26827906
88	MP0002106_abnormal_muscle_physiology	0.26437833
89	MP0008932_abnormal_embryonic_tissue	0.24529303
90	MP0005620_abnormal_muscle_contractility	0.23602105
91	MP0008874_decreased_physiological_sensi	0.23327590
92	MP0002064_seizures	0.23050530
93	MP0005266_abnormal_metabolism	0.21932123
94	MP0000383_abnormal_hair_follicle	0.21673509
95	MP0002572_abnormal_emotion/affect_behav	0.21585868
96	MP0003959_abnormal_lean_body	0.21342191
97	MP0006072_abnormal_retinal_apoptosis	0.21034146
98	MP0000470_abnormal_stomach_morphology	0.20993203
99	MP0003632_abnormal_nervous_system	0.20665152
100	MP0000432_abnormal_head_morphology	0.20057819

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	9.39375879
2	Focal motor seizures (HP:0011153)	9.04698335
3	Acanthocytosis (HP:0001927)	7.20754618
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.08456699
5	Parakeratosis (HP:0001036)	6.53073134
6	Aplastic anemia (HP:0001915)	5.75907516
7	Colon cancer (HP:0003003)	4.89804176
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.83099799
9	Proximal amyotrophy (HP:0007126)	4.79219676
10	Dialeptic seizures (HP:0011146)	4.39857759
11	Vertebral arch anomaly (HP:0008438)	4.26693512
12	Pancreatic cysts (HP:0001737)	4.21482783
13	Hematochezia (HP:0002573)	4.17775924
14	Rectal prolapse (HP:0002035)	4.13444177
15	Bilateral sensorineural hearing impairment (HP:0008619)	3.96356046
16	Congenital ichthyosiform erythroderma (HP:0007431)	3.94896866
17	Spontaneous hematomas (HP:0007420)	3.86721632
18	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.82173412
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.79475213
20	Erythroderma (HP:0001019)	3.65614287
21	Focal seizures (HP:0007359)	3.63908500
22	Difficulty walking (HP:0002355)	3.59687841
23	Scapular winging (HP:0003691)	3.40487092
24	Chromsome breakage (HP:0040012)	3.35622532
25	Conjunctival telangiectasia (HP:0000524)	3.33772996
26	Potter facies (HP:0002009)	3.21055022
27	Facial shape deformation (HP:0011334)	3.21055022
28	Poikilocytosis (HP:0004447)	3.13739504
29	Enlarged kidneys (HP:0000105)	3.03247928
30	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	3.01660518
31	Ulnar bowing (HP:0003031)	2.96620620
32	Overlapping toe (HP:0001845)	2.94798597
33	Albinism (HP:0001022)	2.93875047
34	Esophageal varix (HP:0002040)	2.89706489
35	Pendular nystagmus (HP:0012043)	2.85316413
36	Broad ribs (HP:0000885)	2.77727737
37	Ulnar claw (HP:0001178)	2.76517548
38	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.70286598
39	Hypoplastic iliac wings (HP:0002866)	2.66794111
40	Synostosis of carpal bones (HP:0005048)	2.64953748
41	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.57252903
42	Radial bowing (HP:0002986)	2.56561782
43	Severe visual impairment (HP:0001141)	2.55976087
44	IgM deficiency (HP:0002850)	2.55724617
45	Progressive inability to walk (HP:0002505)	2.54031352
46	Type I transferrin isoform profile (HP:0003642)	2.53424847
47	Abnormality of the renal cortex (HP:0011035)	2.52706424
48	Abnormality of macular pigmentation (HP:0008002)	2.52026909
49	Cystic liver disease (HP:0006706)	2.38294963
50	Abnormality of the renal medulla (HP:0100957)	2.29377159
51	Portal hypertension (HP:0001409)	2.23884866
52	Tubulointerstitial fibrosis (HP:0005576)	2.23559322
53	Pancreatic fibrosis (HP:0100732)	2.21906251
54	Abnormality of the vocal cords (HP:0008777)	2.21288949
55	Hypoplasia of the fovea (HP:0007750)	2.19773574
56	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.19773574
57	Abnormal albumin level (HP:0012116)	2.13672548
58	Hypoalbuminemia (HP:0003073)	2.13672548
59	Cerebellar dysplasia (HP:0007033)	2.09690839
60	Aplasia/Hypoplasia of the macula (HP:0008059)	2.08084908
61	Autoimmune hemolytic anemia (HP:0001890)	2.07920602
62	Gangrene (HP:0100758)	2.06437396
63	Neoplasm of the small intestine (HP:0100833)	2.02530565
64	Tarsal synostosis (HP:0008368)	2.02504296
65	Abnormality of the hepatic vasculature (HP:0006707)	1.99895812
66	Horizontal nystagmus (HP:0000666)	1.97827793
67	Petechiae (HP:0000967)	1.95982214
68	Abnormality of the shoulder girdle musculature (HP:0001435)	1.95100759
69	Nephronophthisis (HP:0000090)	1.93495708
70	Neonatal death (HP:0003811)	1.93387204
71	Decreased circulating renin level (HP:0003351)	1.90743311
72	Tubular atrophy (HP:0000092)	1.89272964
73	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.87745253
74	Thickened calvaria (HP:0002684)	1.86730426
75	Lack of skin elasticity (HP:0100679)	1.85273252
76	Synostosis involving bones of the feet (HP:0009140)	1.82323572
77	Synostosis involving bones of the lower limbs (HP:0009138)	1.82323572
78	Visceral angiomatosis (HP:0100761)	1.82035033
79	Hypokalemia (HP:0002900)	1.80537769
80	Chronic diarrhea (HP:0002028)	1.78094837
81	Neoplasm of the colon (HP:0100273)	1.76317852
82	Pancytopenia (HP:0001876)	1.75213454
83	Congenital sensorineural hearing impairment (HP:0008527)	1.72556365
84	Subcapsular cataract (HP:0000523)	1.72492893
85	Opisthotonus (HP:0002179)	1.72047073
86	Dehydration (HP:0001944)	1.72038356
87	Abnormality of potassium homeostasis (HP:0011042)	1.71755399
88	Hemangiomatosis (HP:0007461)	1.71680026
89	Abnormality of the wing of the ilium (HP:0011867)	1.69788042
90	Abnormality of the fovea (HP:0000493)	1.69330621
91	Medulloblastoma (HP:0002885)	1.68968107
92	Carpal bone hypoplasia (HP:0001498)	1.68201185
93	Aortic valve stenosis (HP:0001650)	1.68083816
94	Congenital hepatic fibrosis (HP:0002612)	1.66737619
95	Recurrent sinusitis (HP:0011108)	1.66178650
96	Glioma (HP:0009733)	1.63648383
97	Retinitis pigmentosa (HP:0000510)	1.61763809
98	Type II lissencephaly (HP:0007260)	1.61275962
99	Palmoplantar keratoderma (HP:0000982)	1.59724896
100	Generalized hypopigmentation (HP:0007513)	1.59709639

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.19023415
2	LATS2	6.57101945
3	ACVR1B	3.06759982
4	PRKD3	2.98737399
5	FRK	2.90151649
6	STK38	2.63714364
7	ZAK	2.56332330
8	NLK	2.55562235
9	BMPR1B	2.16297545
10	STK3	2.10546384
11	MELK	2.05013160
12	MAP2K2	2.03004357
13	LATS1	10.5190401
14	TAF1	1.18061695
15	PRKAA2	1.17133420
16	EIF2AK3	1.00346822
17	MAP3K2	0.98900266
18	KSR2	0.97226425
19	TGFBR1	0.95666969
20	NEK2	0.93729904
21	PIK3CG	0.89775162
22	PDPK1	0.87631557
23	FER	0.83232973
24	GRK7	0.74095691
25	PRKD1	0.73809612
26	MAP2K1	0.71316808
27	CSNK1A1L	0.68738671
28	PINK1	0.68413662
29	TTK	0.67980118
30	TGFBR2	0.65464020
31	IRAK3	0.63840722
32	MARK3	0.63369333
33	PAK3	0.58514740
34	ADRBK1	0.56575513
35	TNK2	0.44963994
36	PRKCI	0.43204267
37	ADRBK2	0.42585791
38	DAPK2	0.42422874
39	GRK5	0.42049301
40	MKNK1	0.39890782
41	STK11	0.38010751
42	PDK2	0.37872521
43	NME1	0.34391157
44	MOS	0.34296499
45	WNK3	0.33596219
46	PLK2	0.32439447
47	CHEK2	0.31029947
48	MAPKAPK5	0.29404558
49	NEK9	0.28947759
50	WNK4	0.26427622
51	PLK1	0.26145460
52	MKNK2	0.24974929
53	MYLK	0.24515318
54	OXSR1	0.24018748
55	BRSK2	0.23082633
56	CDK3	0.21081564
57	PIM1	0.20044248
58	PBK	0.19065447
59	STK10	0.18697682
60	EPHA4	0.18457560
61	TNIK	0.18429053
62	DMPK	0.18399903
63	FGFR1	0.18001849
64	NUAK1	0.17686690
65	CSNK1D	0.16463771
66	ABL1	0.15789180
67	PLK3	0.15635922
68	TAOK3	0.15442784
69	MAPK3	0.14214392
70	MAP3K4	0.13502996
71	NEK1	0.12522597
72	PRKACB	0.11718405
73	PTK2B	0.11214988
74	PRKCH	0.10872582
75	NEK6	0.10126549
76	AKT2	0.09085137
77	PAK6	0.08115597
78	EIF2AK2	0.06418640
79	STK39	0.06414739
80	MAPK1	0.06315276
81	CAMK2A	0.05451280
82	MAPK7	0.05305117
83	PRKACA	0.05097791
84	PAK1	0.04609859
85	ATR	0.04100714
86	MAP3K7	0.02800852
87	TRIM28	0.02590674
88	PRKCE	0.02397447
89	TEC	0.00672736
90	ITK	-0.0630297
91	GSK3B	-0.0564106
92	CSNK1A1	-0.0560046
93	MAP4K2	-0.0552381
94	CDK5	-0.0506866
95	MAPK8	-0.0488340
96	JAK2	-0.0479391
97	GSK3A	-0.0423549
98	ATM	-0.0213170
99	PTK2	-0.0041093
100	TIE1	-0.0004520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.85596894
2	Phototransduction_Homo sapiens_hsa04744	4.15507177
3	Sphingolipid metabolism_Homo sapiens_hsa00600	3.91871836
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.47504034
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.07581160
6	Nicotine addiction_Homo sapiens_hsa05033	2.71074432
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.66927198
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.19607872
9	Taste transduction_Homo sapiens_hsa04742	2.12991557
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.11786111
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.90480700
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.80745879
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.77347295
14	Morphine addiction_Homo sapiens_hsa05032	1.67662630
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54082932
16	One carbon pool by folate_Homo sapiens_hsa00670	1.38377093
17	Histidine metabolism_Homo sapiens_hsa00340	1.32775377
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.29060899
19	GABAergic synapse_Homo sapiens_hsa04727	1.22334923
20	Calcium signaling pathway_Homo sapiens_hsa04020	1.19602612
21	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.19535408
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16944279
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.14732360
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08982175
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03048721
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02758946
27	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.01789687
28	ABC transporters_Homo sapiens_hsa02010	0.98487672
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96558361
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95875448
31	Tyrosine metabolism_Homo sapiens_hsa00350	0.94269442
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92328301
33	Butanoate metabolism_Homo sapiens_hsa00650	0.91403604
34	ECM-receptor interaction_Homo sapiens_hsa04512	0.90878569
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.90850722
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90322219
37	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.88434316
38	Viral myocarditis_Homo sapiens_hsa05416	0.87418951
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86402711
40	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.85549070
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84171620
42	Basal transcription factors_Homo sapiens_hsa03022	0.81967690
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.81664797
44	Homologous recombination_Homo sapiens_hsa03440	0.80247862
45	Adherens junction_Homo sapiens_hsa04520	0.78381243
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.78280489
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77940938
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.76651679
49	VEGF signaling pathway_Homo sapiens_hsa04370	0.76483886
50	Lysine degradation_Homo sapiens_hsa00310	0.74449417
51	Serotonergic synapse_Homo sapiens_hsa04726	0.74202089
52	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.73740322
53	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.65904970
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.65591560
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.64743719
56	Fatty acid degradation_Homo sapiens_hsa00071	0.63467114
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63098223
58	Olfactory transduction_Homo sapiens_hsa04740	0.61047424
59	Colorectal cancer_Homo sapiens_hsa05210	0.59656859
60	Bile secretion_Homo sapiens_hsa04976	0.59354087
61	Hippo signaling pathway_Homo sapiens_hsa04390	0.59305211
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52414424
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.50408876
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50336926
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49029683
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47516740
67	Melanogenesis_Homo sapiens_hsa04916	0.43709982
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43637109
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41565503
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38852969
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.37863896
72	Thyroid cancer_Homo sapiens_hsa05216	0.36769911
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35924925
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.35668669
75	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.34705802
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34512427
77	Propanoate metabolism_Homo sapiens_hsa00640	0.30031562
78	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.29846794
79	African trypanosomiasis_Homo sapiens_hsa05143	0.29634450
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.29397134
81	Cell cycle_Homo sapiens_hsa04110	0.29029931
82	Salivary secretion_Homo sapiens_hsa04970	0.26699246
83	Circadian entrainment_Homo sapiens_hsa04713	0.26314675
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.25516912
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23754284
86	Folate biosynthesis_Homo sapiens_hsa00790	0.23123616
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22907840
88	Retinol metabolism_Homo sapiens_hsa00830	0.21443024
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.21298984
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20978333
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.19800524
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.19775983
93	Metabolic pathways_Homo sapiens_hsa01100	0.17966785
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17629541
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.16765194
96	Pancreatic cancer_Homo sapiens_hsa05212	0.16305729
97	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.15655814
98	Oocyte meiosis_Homo sapiens_hsa04114	0.13092020
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.08088851
100	Gap junction_Homo sapiens_hsa04540	0.07490130

RBM17P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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