ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	7.85893134
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.37988194
3	meiotic chromosome segregation (GO:0045132)	7.26808400
4	cilium movement (GO:0003341)	6.58575018
5	centriole replication (GO:0007099)	6.11576197
6	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	5.71579185
7	sphingosine metabolic process (GO:0006670)	5.56417975
8	retinal cone cell development (GO:0046549)	5.30499524
9	inner ear receptor stereocilium organization (GO:0060122)	5.25458263
10	peptidyl-histidine modification (GO:0018202)	5.13031133
11	sphingoid metabolic process (GO:0046519)	5.09946574
12	negative regulation of axon guidance (GO:1902668)	5.03243944
13	diol metabolic process (GO:0034311)	5.00573221
14	axonemal dynein complex assembly (GO:0070286)	4.87689883
15	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	4.76893680
16	DNA double-strand break processing (GO:0000729)	4.61988994
17	regulation of meiosis I (GO:0060631)	4.40912354
18	kinetochore organization (GO:0051383)	4.40271429
19	cilium morphogenesis (GO:0060271)	4.37481266
20	cell wall macromolecule catabolic process (GO:0016998)	4.36453866
21	motile cilium assembly (GO:0044458)	4.32998932
22	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	4.27872183
23	centriole assembly (GO:0098534)	4.08001398
24	negative regulation of cell cycle G2/M phase transition (GO:1902750)	4.05232772
25	protein-chromophore linkage (GO:0018298)	3.94534055
26	regulation of axon guidance (GO:1902667)	3.90687084
27	axoneme assembly (GO:0035082)	3.75676235
28	DNA methylation involved in gamete generation (GO:0043046)	3.73060825
29	resolution of meiotic recombination intermediates (GO:0000712)	3.71474751
30	cilium organization (GO:0044782)	3.66360303
31	regulation of DNA endoreduplication (GO:0032875)	3.64551022
32	cell wall macromolecule metabolic process (GO:0044036)	3.59753806
33	serotonin receptor signaling pathway (GO:0007210)	3.51375002
34	auditory receptor cell stereocilium organization (GO:0060088)	3.45920554
35	cilium assembly (GO:0042384)	3.41663677
36	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.36802572
37	double-strand break repair via homologous recombination (GO:0000724)	3.35786012
38	positive regulation of vasculogenesis (GO:2001214)	3.34887785
39	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.34311082
40	recombinational repair (GO:0000725)	3.33511497
41	intraciliary transport (GO:0042073)	3.33494951
42	centrosome duplication (GO:0051298)	3.31821295
43	microtubule depolymerization (GO:0007019)	3.29581643
44	microtubule polymerization or depolymerization (GO:0031109)	3.26362604
45	cilium or flagellum-dependent cell motility (GO:0001539)	3.25048432
46	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.17970914
47	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.17970914
48	paraxial mesoderm development (GO:0048339)	3.13132068
49	regulation of hippo signaling (GO:0035330)	3.11960475
50	detection of light stimulus involved in visual perception (GO:0050908)	3.11235946
51	detection of light stimulus involved in sensory perception (GO:0050962)	3.11235946
52	regulation of pigment cell differentiation (GO:0050932)	3.10002258
53	smoothened signaling pathway (GO:0007224)	3.07431479
54	eye photoreceptor cell development (GO:0042462)	3.05939476
55	determination of left/right symmetry (GO:0007368)	3.05286114
56	synapsis (GO:0007129)	3.04809491
57	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.03416261
58	glomerulus development (GO:0032835)	3.03062348
59	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.02958594
60	photoreceptor cell development (GO:0042461)	3.02296058
61	negative regulation of DNA recombination (GO:0045910)	2.99572673
62	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.98388155
63	cell proliferation in forebrain (GO:0021846)	2.97263196
64	gamma-aminobutyric acid transport (GO:0015812)	2.94831129
65	ventricular system development (GO:0021591)	2.93864495
66	heme transport (GO:0015886)	2.92071777
67	transmission of nerve impulse (GO:0019226)	2.87320863
68	replication fork processing (GO:0031297)	2.86390812
69	determination of bilateral symmetry (GO:0009855)	2.84039267
70	reciprocal meiotic recombination (GO:0007131)	2.83862811
71	reciprocal DNA recombination (GO:0035825)	2.83862811
72	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.82856950
73	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.82856950
74	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.82856950
75	positive regulation of developmental pigmentation (GO:0048087)	2.81738835
76	sister chromatid segregation (GO:0000819)	2.80814275
77	fucose catabolic process (GO:0019317)	2.80002750
78	L-fucose metabolic process (GO:0042354)	2.80002750
79	L-fucose catabolic process (GO:0042355)	2.80002750
80	double-strand break repair via nonhomologous end joining (GO:0006303)	2.79004589
81	non-recombinational repair (GO:0000726)	2.79004589
82	notochord development (GO:0030903)	2.78946106
83	specification of symmetry (GO:0009799)	2.78875662
84	olfactory bulb development (GO:0021772)	2.76523268
85	centrosome organization (GO:0051297)	2.74924592
86	cellular component assembly involved in morphogenesis (GO:0010927)	2.73901447
87	double-strand break repair (GO:0006302)	2.72619444
88	left/right pattern formation (GO:0060972)	2.71133735
89	generation of neurons (GO:0048699)	2.69442712
90	photoreceptor cell maintenance (GO:0045494)	2.68193164
91	otic vesicle formation (GO:0030916)	2.68002889
92	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.66202842
93	chromatin remodeling at centromere (GO:0031055)	2.66134734
94	regulation of neuroblast proliferation (GO:1902692)	2.66099245
95	metaphase plate congression (GO:0051310)	2.65357927
96	oogenesis (GO:0048477)	2.65218255
97	retinal rod cell development (GO:0046548)	2.65203038
98	regulation of glomerular filtration (GO:0003093)	2.65047165
99	regulation of double-strand break repair (GO:2000779)	2.62985880
100	response to pheromone (GO:0019236)	2.62817691

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.27006764
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.18814233
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.17157847
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.12508011
5	VDR_22108803_ChIP-Seq_LS180_Human	2.89758884
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.87992273
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75698946
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.70662633
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.60047730
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50362352
11	P300_19829295_ChIP-Seq_ESCs_Human	2.41012508
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.39386048
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.39068189
14	FUS_26573619_Chip-Seq_HEK293_Human	2.31545610
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31384969
16	EWS_26573619_Chip-Seq_HEK293_Human	2.15275234
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.05123226
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.02103903
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02103903
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.97149440
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.93033963
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92604819
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.91788607
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.89982604
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87478179
26	STAT3_23295773_ChIP-Seq_U87_Human	1.87170029
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.85812205
28	AR_25329375_ChIP-Seq_VCAP_Human	1.81597001
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.72247263
30	TCF4_23295773_ChIP-Seq_U87_Human	1.68719489
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64586660
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64529783
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63414702
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62895367
35	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62402850
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.62378990
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.61153968
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61147871
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58799367
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58361346
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57242069
42	RXR_22108803_ChIP-Seq_LS180_Human	1.56168952
43	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.55138424
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54028223
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.53400004
46	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51334222
47	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50362734
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49786716
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.46712269
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43150482
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42514196
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40222885
53	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.36815448
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36128632
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.35054583
56	JUN_21703547_ChIP-Seq_K562_Human	1.34766528
57	TP53_16413492_ChIP-PET_HCT116_Human	1.33206638
58	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.33082082
59	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.31938473
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31307163
61	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25918519
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.25020431
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25020431
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23225788
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23225788
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.22021826
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19825827
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19109562
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17948259
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.17854138
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17778639
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17097466
73	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14291561
74	TBL1_22424771_ChIP-Seq_293T_Human	1.12963184
75	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12848106
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12796891
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12629870
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12594840
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11501735
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11195795
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07958750
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07378870
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07136155
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06618479
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.06242497
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05989525
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05731082
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03577028
89	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.03109883
90	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.03046174
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02803739
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02553193
93	KDM2B_26808549_Chip-Seq_REH_Human	1.01335373
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01261263
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00634728
96	SOX9_26525672_Chip-Seq_HEART_Mouse	0.99920239
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99221109
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97806964
99	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95213137
100	NFYA_21822215_ChIP-Seq_K562_Human	0.92901012

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.21720477
2	MP0002837_dystrophic_cardiac_calcinosis	4.25205307
3	MP0002653_abnormal_ependyma_morphology	4.22965800
4	MP0004043_abnormal_pH_regulation	4.13386267
5	MP0005171_absent_coat_pigmentation	4.10367690
6	MP0000569_abnormal_digit_pigmentation	3.67660734
7	MP0002938_white_spotting	3.55118640
8	MP0003890_abnormal_embryonic-extraembry	2.71250885
9	MP0000566_synostosis	2.67898438
10	MP0003646_muscle_fatigue	2.52209092
11	MP0006292_abnormal_olfactory_placode	2.48331774
12	MP0008057_abnormal_DNA_replication	2.29172519
13	MP0010094_abnormal_chromosome_stability	2.17214727
14	MP0008877_abnormal_DNA_methylation	2.08917530
15	MP0000372_irregular_coat_pigmentation	2.07088999
16	MP0003045_fibrosis	1.99944839
17	MP0005551_abnormal_eye_electrophysiolog	1.95902452
18	MP0006072_abnormal_retinal_apoptosis	1.93630776
19	MP0008961_abnormal_basal_metabolism	1.91086009
20	MP0003937_abnormal_limbs/digits/tail_de	1.86968550
21	MP0001486_abnormal_startle_reflex	1.67337066
22	MP0000579_abnormal_nail_morphology	1.61602111
23	MP0002928_abnormal_bile_duct	1.56541773
24	MP0003718_maternal_effect	1.46529361
25	MP0004381_abnormal_hair_follicle	1.42623250
26	MP0008058_abnormal_DNA_repair	1.39673468
27	MP0005248_abnormal_Harderian_gland	1.38418385
28	MP0005365_abnormal_bile_salt	1.36687789
29	MP0003938_abnormal_ear_development	1.33324568
30	MP0010352_gastrointestinal_tract_polyps	1.32090115
31	MP0002736_abnormal_nociception_after	1.29060208
32	MP0009697_abnormal_copulation	1.27236518
33	MP0003879_abnormal_hair_cell	1.26344460
34	MP0002102_abnormal_ear_morphology	1.22740688
35	MP0003950_abnormal_plasma_membrane	1.19413046
36	MP0002282_abnormal_trachea_morphology	1.19399057
37	MP0009046_muscle_twitch	1.17647846
38	MP0001346_abnormal_lacrimal_gland	1.16769149
39	MP0003880_abnormal_central_pattern	1.15212621
40	MP0000778_abnormal_nervous_system	1.14661874
41	MP0005395_other_phenotype	1.13834594
42	MP0005174_abnormal_tail_pigmentation	1.13200521
43	MP0009745_abnormal_behavioral_response	1.08620931
44	MP0005408_hypopigmentation	1.07801799
45	MP0000534_abnormal_ureter_morphology	1.05651687
46	MP0002272_abnormal_nervous_system	1.03555680
47	MP0000428_abnormal_craniofacial_morphol	1.01966094
48	MP0010030_abnormal_orbit_morphology	1.01772150
49	MP0003195_calcinosis	1.00447253
50	MP0002168_other_aberrant_phenotype	1.00142749
51	MP0000383_abnormal_hair_follicle	0.99022347
52	MP0005253_abnormal_eye_physiology	0.94621918
53	MP0001293_anophthalmia	0.94151717
54	MP0002751_abnormal_autonomic_nervous	0.93142783
55	MP0004133_heterotaxia	0.91632158
56	MP0001968_abnormal_touch/_nociception	0.90801295
57	MP0000026_abnormal_inner_ear	0.88882353
58	MP0002160_abnormal_reproductive_system	0.88342199
59	MP0005195_abnormal_posterior_eye	0.88031797
60	MP0001984_abnormal_olfaction	0.87812279
61	MP0002090_abnormal_vision	0.86794777
62	MP0001286_abnormal_eye_development	0.86460731
63	MP0002234_abnormal_pharynx_morphology	0.85568162
64	MP0008789_abnormal_olfactory_epithelium	0.85283718
65	MP0001929_abnormal_gametogenesis	0.83421734
66	MP0008872_abnormal_physiological_respon	0.82715579
67	MP0003698_abnormal_male_reproductive	0.81898495
68	MP0000749_muscle_degeneration	0.81063809
69	MP0002572_abnormal_emotion/affect_behav	0.80732777
70	MP0010307_abnormal_tumor_latency	0.80385476
71	MP0000653_abnormal_sex_gland	0.79292439
72	MP0002735_abnormal_chemical_nociception	0.78954827
73	MP0003283_abnormal_digestive_organ	0.78453055
74	MP0000631_abnormal_neuroendocrine_gland	0.77864110
75	MP0004145_abnormal_muscle_electrophysio	0.77852836
76	MP0003806_abnormal_nucleotide_metabolis	0.77639657
77	MP0006276_abnormal_autonomic_nervous	0.76774366
78	MP0002752_abnormal_somatic_nervous	0.76713372
79	MP0003861_abnormal_nervous_system	0.76305752
80	MP0005085_abnormal_gallbladder_physiolo	0.76281345
81	MP0000427_abnormal_hair_cycle	0.76165862
82	MP0002210_abnormal_sex_determination	0.75597610
83	MP0001324_abnormal_eye_pigmentation	0.74601989
84	MP0001501_abnormal_sleep_pattern	0.74393571
85	MP0002095_abnormal_skin_pigmentation	0.74319516
86	MP0004742_abnormal_vestibular_system	0.73183326
87	MP0005075_abnormal_melanosome_morpholog	0.72280080
88	MP0002075_abnormal_coat/hair_pigmentati	0.71740910
89	MP0003878_abnormal_ear_physiology	0.70339488
90	MP0005377_hearing/vestibular/ear_phenot	0.70339488
91	MP0001119_abnormal_female_reproductive	0.69786629
92	MP0000432_abnormal_head_morphology	0.68525345
93	MP0002734_abnormal_mechanical_nocicepti	0.67638138
94	MP0008932_abnormal_embryonic_tissue	0.66694077
95	MP0003755_abnormal_palate_morphology	0.65842737
96	MP0001485_abnormal_pinna_reflex	0.62698139
97	MP0002233_abnormal_nose_morphology	0.62342393
98	MP0009250_abnormal_appendicular_skeleto	0.62061442
99	MP0001145_abnormal_male_reproductive	0.61983750
100	MP0005266_abnormal_metabolism	0.61023298

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	5.78911587
2	Pancreatic fibrosis (HP:0100732)	5.61812555
3	True hermaphroditism (HP:0010459)	4.86443345
4	Chromsome breakage (HP:0040012)	4.66937565
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.60975817
6	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.58371788
7	Cystic liver disease (HP:0006706)	4.57525487
8	Tubulointerstitial fibrosis (HP:0005576)	4.38509080
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.22079276
10	Focal motor seizures (HP:0011153)	3.98721247
11	Abnormal ciliary motility (HP:0012262)	3.79677895
12	Tubular atrophy (HP:0000092)	3.72938343
13	Supernumerary spleens (HP:0009799)	3.62303214
14	Colon cancer (HP:0003003)	3.62152344
15	Molar tooth sign on MRI (HP:0002419)	3.58624555
16	Abnormality of midbrain morphology (HP:0002418)	3.58624555
17	Absent/shortened dynein arms (HP:0200106)	3.55324353
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.55324353
19	Abnormality of the ileum (HP:0001549)	3.52073989
20	Vitreoretinal degeneration (HP:0000655)	3.51175202
21	Tubulointerstitial abnormality (HP:0001969)	3.47265821
22	Meckel diverticulum (HP:0002245)	3.39281848
23	Abnormal respiratory motile cilium physiology (HP:0012261)	3.37305508
24	Nephronophthisis (HP:0000090)	3.36590484
25	Abnormal respiratory motile cilium morphology (HP:0005938)	3.32342462
26	Abnormal respiratory epithelium morphology (HP:0012253)	3.32342462
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.19836981
28	Abnormality of chromosome stability (HP:0003220)	3.11883195
29	Short 4th metacarpal (HP:0010044)	3.10463669
30	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.10463669
31	Abnormality of the renal medulla (HP:0100957)	3.05651958
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.04575443
33	Asplenia (HP:0001746)	2.94359717
34	Congenital hepatic fibrosis (HP:0002612)	2.89814795
35	Sloping forehead (HP:0000340)	2.88638374
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.87642559
37	Anencephaly (HP:0002323)	2.85722082
38	Abnormality of the preputium (HP:0100587)	2.77802969
39	Abnormal biliary tract physiology (HP:0012439)	2.74582306
40	Bile duct proliferation (HP:0001408)	2.74582306
41	Abnormality of the renal cortex (HP:0011035)	2.71694478
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.67953865
43	Abnormal gallbladder physiology (HP:0012438)	2.65552478
44	Cholecystitis (HP:0001082)	2.65552478
45	Clubbing of toes (HP:0100760)	2.63741665
46	Abnormal drinking behavior (HP:0030082)	2.61070509
47	Polydipsia (HP:0001959)	2.61070509
48	Abnormality of the labia minora (HP:0012880)	2.60045818
49	Dyschromatopsia (HP:0007641)	2.57610329
50	Small intestinal stenosis (HP:0012848)	2.56819642
51	Duodenal stenosis (HP:0100867)	2.56819642
52	Postaxial foot polydactyly (HP:0001830)	2.56263290
53	Abnormality of the carotid arteries (HP:0005344)	2.46260737
54	Bifid scrotum (HP:0000048)	2.45356815
55	Hepatocellular necrosis (HP:0001404)	2.44116479
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.42636713
57	Aqueductal stenosis (HP:0002410)	2.40745013
58	Rhinitis (HP:0012384)	2.37639159
59	Furrowed tongue (HP:0000221)	2.36740682
60	Ependymoma (HP:0002888)	2.34387472
61	Attenuation of retinal blood vessels (HP:0007843)	2.30297062
62	Oligohydramnios (HP:0001562)	2.29552699
63	Amelogenesis imperfecta (HP:0000705)	2.29169245
64	Abnormality of the duodenum (HP:0002246)	2.23425290
65	Medial flaring of the eyebrow (HP:0010747)	2.21126171
66	Sclerocornea (HP:0000647)	2.18674283
67	Abolished electroretinogram (ERG) (HP:0000550)	2.16067428
68	Enlarged kidneys (HP:0000105)	2.15131489
69	Ectopic kidney (HP:0000086)	2.13446320
70	Facial shape deformation (HP:0011334)	2.13123127
71	Potter facies (HP:0002009)	2.13123127
72	Abnormality of the 4th metacarpal (HP:0010012)	2.11696144
73	Abnormality of the astrocytes (HP:0100707)	2.09061289
74	Astrocytoma (HP:0009592)	2.09061289
75	Small hand (HP:0200055)	2.08997088
76	Acanthocytosis (HP:0001927)	2.08816523
77	Acute necrotizing encephalopathy (HP:0006965)	2.07362361
78	Oculomotor apraxia (HP:0000657)	2.06755094
79	Astigmatism (HP:0000483)	2.05330875
80	Preaxial hand polydactyly (HP:0001177)	2.04579558
81	Rhabdomyosarcoma (HP:0002859)	2.04137532
82	Abnormality of macular pigmentation (HP:0008002)	2.02918586
83	Volvulus (HP:0002580)	1.98352046
84	Triphalangeal thumb (HP:0001199)	1.97931695
85	Male pseudohermaphroditism (HP:0000037)	1.97777741
86	Bilateral sensorineural hearing impairment (HP:0008619)	1.97339382
87	Renal hypoplasia (HP:0000089)	1.96202012
88	Enlarged penis (HP:0000040)	1.95174701
89	Arteriovenous malformation (HP:0100026)	1.89978954
90	Focal seizures (HP:0007359)	1.89863751
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.87194713
92	Multicystic kidney dysplasia (HP:0000003)	1.86450598
93	Optic nerve hypoplasia (HP:0000609)	1.84818025
94	Hepatic necrosis (HP:0002605)	1.84427046
95	Chronic hepatic failure (HP:0100626)	1.82724781
96	Narrow forehead (HP:0000341)	1.82072414
97	Progressive macrocephaly (HP:0004481)	1.81630909
98	Absent radius (HP:0003974)	1.80899805
99	Intestinal atresia (HP:0011100)	1.80377077
100	Glioma (HP:0009733)	1.78954261

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	5.41305729
2	LATS1	5.30144024
3	FRK	4.19836146
4	STK38L	3.65403350
5	BMPR1B	3.21853972
6	BRSK2	3.16890000
7	ACVR1B	2.63450288
8	CASK	2.54094049
9	EPHA4	2.47249425
10	WNK4	2.46453037
11	MKNK2	2.45050244
12	LATS2	2.33582646
13	TNIK	2.04163528
14	BRSK1	1.99897890
15	STK3	1.98113669
16	CDC7	1.81010904
17	STK39	1.73578236
18	MAP3K4	1.69367066
19	ZAK	1.65645141
20	FGFR2	1.62667608
21	WEE1	1.56468549
22	TAF1	1.52813428
23	MKNK1	1.52787092
24	MARK3	1.46577162
25	NEK2	1.44685004
26	TTK	1.43436345
27	NLK	1.36492198
28	PTK2B	1.36166682
29	MELK	1.34293161
30	PLK2	1.28610705
31	PLK3	1.27199547
32	PLK1	1.19793450
33	IRAK1	1.10096577
34	PKN2	1.09170806
35	NUAK1	1.05855778
36	INSRR	1.05316381
37	TGFBR1	1.03177114
38	MAP3K10	1.03120595
39	PLK4	0.99177980
40	NTRK3	0.98780816
41	PINK1	0.96801409
42	CHEK2	0.94714204
43	PAK3	0.93455488
44	OXSR1	0.92227213
45	GRK1	0.87644284
46	STK38	0.85928206
47	FLT3	0.83886793
48	PRKD3	0.82124909
49	PKN1	0.79507841
50	MARK1	0.77895858
51	MAP3K2	0.74113077
52	KSR2	0.69226351
53	MAP2K2	0.67533885
54	PNCK	0.65674056
55	WNK3	0.62687995
56	NTRK2	0.62301176
57	BRD4	0.60337207
58	PRKCI	0.56123081
59	MAPKAPK5	0.56098272
60	MAP2K1	0.55534409
61	MAPK13	0.55353639
62	ATR	0.52559700
63	ATM	0.50624525
64	PIK3CG	0.50391230
65	MINK1	0.48220238
66	CDK3	0.47858657
67	FGFR1	0.47310840
68	TIE1	0.47142824
69	PRKCG	0.46255200
70	VRK1	0.44616997
71	STK11	0.43873578
72	MUSK	0.43678564
73	PRKCE	0.39861218
74	EPHB2	0.38879379
75	PRKAA2	0.38697085
76	IRAK2	0.36490661
77	VRK2	0.35852530
78	PAK6	0.32400176
79	ADRBK1	0.30488585
80	MAP2K7	0.29935253
81	ADRBK2	0.29394125
82	GSK3A	0.28513541
83	SGK1	0.27364579
84	CAMK1G	0.27303017
85	CDK1	0.27282331
86	AURKB	0.26860237
87	GRK7	0.26500986
88	SGK3	0.23728506
89	AKT3	0.23461910
90	FER	0.23407579
91	CSNK1D	0.23167572
92	WNK1	0.22207183
93	SGK2	0.21229622
94	CHEK1	0.19837529
95	MAP4K2	0.18894444
96	NEK1	0.18104986
97	CSNK1G2	0.17705245
98	TGFBR2	0.17606074
99	ERBB2	0.15970083
100	DYRK3	0.15416019

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.76465581
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.75287767
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.73016964
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.42117337
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.86830562
6	Homologous recombination_Homo sapiens_hsa03440	2.73455356
7	Nicotine addiction_Homo sapiens_hsa05033	2.43129981
8	Phototransduction_Homo sapiens_hsa04744	2.29550424
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.20505479
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.80540771
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.77075933
12	Olfactory transduction_Homo sapiens_hsa04740	1.67637365
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65394370
14	Taste transduction_Homo sapiens_hsa04742	1.62977981
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58102613
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52060051
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.51637131
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49803500
19	Sphingolipid metabolism_Homo sapiens_hsa00600	1.49759008
20	Mismatch repair_Homo sapiens_hsa03430	1.46799264
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46520226
22	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.44581979
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.43752189
24	Lysine degradation_Homo sapiens_hsa00310	1.43726857
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.42889339
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42371632
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38981826
28	Morphine addiction_Homo sapiens_hsa05032	1.32083260
29	Base excision repair_Homo sapiens_hsa03410	1.27530316
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26430959
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.24193455
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.22292726
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.20851637
34	Glycerolipid metabolism_Homo sapiens_hsa00561	1.20489882
35	Basal transcription factors_Homo sapiens_hsa03022	1.19884514
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12781644
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.08578733
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07314018
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.05750939
40	Serotonergic synapse_Homo sapiens_hsa04726	1.02923224
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.01470207
42	Histidine metabolism_Homo sapiens_hsa00340	1.00865022
43	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.99667597
44	One carbon pool by folate_Homo sapiens_hsa00670	0.99039969
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.96468397
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96400562
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86889961
48	Oxidative phosphorylation_Homo sapiens_hsa00190	0.86076767
49	GABAergic synapse_Homo sapiens_hsa04727	0.85202235
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.82177803
51	Huntingtons disease_Homo sapiens_hsa05016	0.81165601
52	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80535992
53	ABC transporters_Homo sapiens_hsa02010	0.79343951
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76508801
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.76106438
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75419946
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.71727610
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.69801501
59	Butanoate metabolism_Homo sapiens_hsa00650	0.67924936
60	Purine metabolism_Homo sapiens_hsa00230	0.66486762
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.65582671
62	Circadian entrainment_Homo sapiens_hsa04713	0.65489136
63	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.64583672
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.64225421
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.63010408
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61651928
67	Cell cycle_Homo sapiens_hsa04110	0.61520269
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61380552
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59864853
70	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58759877
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.57995516
72	DNA replication_Homo sapiens_hsa03030	0.57678232
73	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57395125
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.56447316
75	Gap junction_Homo sapiens_hsa04540	0.55114861
76	Salivary secretion_Homo sapiens_hsa04970	0.54067473
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53173653
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51686209
79	Parkinsons disease_Homo sapiens_hsa05012	0.50065481
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47882005
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47448579
82	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.47257740
83	RNA degradation_Homo sapiens_hsa03018	0.46618247
84	Fatty acid degradation_Homo sapiens_hsa00071	0.46043947
85	Retinol metabolism_Homo sapiens_hsa00830	0.45138829
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44586781
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43943501
88	Bile secretion_Homo sapiens_hsa04976	0.43590891
89	Metabolic pathways_Homo sapiens_hsa01100	0.43147142
90	Protein export_Homo sapiens_hsa03060	0.41296768
91	Oocyte meiosis_Homo sapiens_hsa04114	0.40802074
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40609228
93	Long-term depression_Homo sapiens_hsa04730	0.40138624
94	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.39804960
95	Propanoate metabolism_Homo sapiens_hsa00640	0.39465123
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38491344
97	ECM-receptor interaction_Homo sapiens_hsa04512	0.38351772
98	Colorectal cancer_Homo sapiens_hsa05210	0.37874614
99	Alzheimers disease_Homo sapiens_hsa05010	0.37476155
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.35930070

RBM17P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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