RBM19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.32844476
2nuclear pore organization (GO:0006999)6.00891015
3pore complex assembly (GO:0046931)4.93188734
4formation of translation preinitiation complex (GO:0001731)4.92777330
5IMP biosynthetic process (GO:0006188)4.69571960
6nucleobase biosynthetic process (GO:0046112)4.69557868
7folic acid-containing compound biosynthetic process (GO:0009396)4.66876425
8protein localization to kinetochore (GO:0034501)4.51522275
9mitotic nuclear envelope disassembly (GO:0007077)4.51182409
10DNA unwinding involved in DNA replication (GO:0006268)4.42270296
11purine nucleobase biosynthetic process (GO:0009113)4.37250343
12folic acid metabolic process (GO:0046655)4.26634531
13membrane disassembly (GO:0030397)4.20195503
14nuclear envelope disassembly (GO:0051081)4.20195503
15maturation of SSU-rRNA (GO:0030490)4.12825489
16ribosome assembly (GO:0042255)4.02228745
17DNA replication checkpoint (GO:0000076)3.98685558
18IMP metabolic process (GO:0046040)3.97676065
19regulation of gene silencing by RNA (GO:0060966)3.93270290
20regulation of posttranscriptional gene silencing (GO:0060147)3.93270290
21regulation of gene silencing by miRNA (GO:0060964)3.93270290
22heterochromatin organization (GO:0070828)3.91453433
23DNA replication initiation (GO:0006270)3.90398446
24DNA strand elongation involved in DNA replication (GO:0006271)3.81945178
25DNA replication-dependent nucleosome assembly (GO:0006335)3.75458777
26DNA replication-dependent nucleosome organization (GO:0034723)3.75458777
27protein localization to chromosome, centromeric region (GO:0071459)3.74230808
28mitotic metaphase plate congression (GO:0007080)3.71817699
29mitochondrial RNA metabolic process (GO:0000959)3.70080627
30DNA duplex unwinding (GO:0032508)3.69446043
31regulation of translational fidelity (GO:0006450)3.68694024
32DNA geometric change (GO:0032392)3.68277352
33ribosome biogenesis (GO:0042254)3.67160414
34DNA strand elongation (GO:0022616)3.65929757
35dosage compensation (GO:0007549)3.64622594
36positive regulation of chromosome segregation (GO:0051984)3.58667228
37rRNA methylation (GO:0031167)3.55508918
38alternative mRNA splicing, via spliceosome (GO:0000380)3.50719001
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42971729
40maturation of 5.8S rRNA (GO:0000460)3.41484417
41rRNA modification (GO:0000154)3.41086091
42pre-miRNA processing (GO:0031054)3.40309161
43activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.39344354
44ribonucleoprotein complex biogenesis (GO:0022613)3.36505224
45mitotic sister chromatid segregation (GO:0000070)3.34954308
46mRNA cleavage (GO:0006379)3.34817074
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33060803
48negative regulation of mRNA processing (GO:0050686)3.32233256
49nuclear envelope organization (GO:0006998)3.31478372
50peptidyl-arginine omega-N-methylation (GO:0035247)3.30008294
51ribosomal small subunit assembly (GO:0000028)3.29831229
52negative regulation of histone methylation (GO:0031061)3.26670865
53regulation of DNA damage checkpoint (GO:2000001)3.25840473
54mitotic chromosome condensation (GO:0007076)3.24383178
55regulation of translational termination (GO:0006449)3.23719684
56translational initiation (GO:0006413)3.23361033
57regulation of histone H3-K9 methylation (GO:0051570)3.23261260
58metaphase plate congression (GO:0051310)3.22606467
59chromatin assembly (GO:0031497)3.21124514
60telomere maintenance via semi-conservative replication (GO:0032201)3.20863027
61negative regulation of mRNA metabolic process (GO:1903312)3.18413358
62sister chromatid segregation (GO:0000819)3.17499548
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16385613
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16385613
65positive regulation of mitotic sister chromatid separation (GO:1901970)3.16385613
66ribosomal large subunit biogenesis (GO:0042273)3.15683908
67regulation of spindle organization (GO:0090224)3.15048439
68rRNA processing (GO:0006364)3.13314012
69regulation of sister chromatid cohesion (GO:0007063)3.11863105
70translational termination (GO:0006415)3.10807921
71viral transcription (GO:0019083)3.10680810
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09053000
73telomere maintenance via recombination (GO:0000722)3.08824361
74chromatin assembly or disassembly (GO:0006333)3.08771270
75peptidyl-arginine N-methylation (GO:0035246)3.08651587
76peptidyl-arginine methylation (GO:0018216)3.08651587
77tetrahydrofolate metabolic process (GO:0046653)3.08576226
78chromatin remodeling at centromere (GO:0031055)3.07971409
79viral mRNA export from host cell nucleus (GO:0046784)3.07627525
80rRNA metabolic process (GO:0016072)3.04895529
81homocysteine metabolic process (GO:0050667)3.04657518
82transcription from mitochondrial promoter (GO:0006390)3.04519922
83histone H3-K36 demethylation (GO:0070544)3.04239030
84ribosomal small subunit biogenesis (GO:0042274)3.01389154
85folic acid-containing compound metabolic process (GO:0006760)2.99833555
86mitotic recombination (GO:0006312)2.99384928
87rRNA transcription (GO:0009303)2.97665914
88positive regulation of SMAD protein import into nucleus (GO:0060391)2.96542618
89regulation of mitotic spindle organization (GO:0060236)2.95030170
90positive thymic T cell selection (GO:0045059)2.94998961
91tRNA modification (GO:0006400)2.93615827
92spliceosomal tri-snRNP complex assembly (GO:0000244)2.93268509
93DNA conformation change (GO:0071103)2.93182514
94DNA replication-independent nucleosome assembly (GO:0006336)2.92357161
95DNA replication-independent nucleosome organization (GO:0034724)2.92357161
96cellular hyperosmotic response (GO:0071474)2.91982028
97kinetochore organization (GO:0051383)2.91501563
98pteridine-containing compound biosynthetic process (GO:0042559)2.91489416
99regulation of RNA export from nucleus (GO:0046831)2.91327789
100negative regulation of RNA splicing (GO:0033119)2.90439060
101CENP-A containing nucleosome assembly (GO:0034080)2.89994414
102translational elongation (GO:0006414)2.87884243
103glycine metabolic process (GO:0006544)2.87083380
104histone arginine methylation (GO:0034969)2.85656997
105purine nucleotide salvage (GO:0032261)2.85448454
106L-serine metabolic process (GO:0006563)2.83977778
107double-strand break repair via nonhomologous end joining (GO:0006303)2.82006163
108non-recombinational repair (GO:0000726)2.82006163
109spliceosomal snRNP assembly (GO:0000387)2.79247955
110telomere maintenance via telomere lengthening (GO:0010833)2.79069923
111mRNA transport (GO:0051028)2.78729406
112regulation of centrosome cycle (GO:0046605)2.76582537
113negative regulation of translational initiation (GO:0045947)2.76331265
114thymic T cell selection (GO:0045061)2.76281251
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.74797224
116establishment of chromosome localization (GO:0051303)2.73030283
117mitotic sister chromatid cohesion (GO:0007064)2.72915823
118tRNA methylation (GO:0030488)2.72461113
119histone H2A monoubiquitination (GO:0035518)2.72408381
120regulation of chromosome segregation (GO:0051983)2.71518475
121rRNA catabolic process (GO:0016075)2.68932396
122protein complex localization (GO:0031503)2.68861959
123pseudouridine synthesis (GO:0001522)2.68585114
124kinetochore assembly (GO:0051382)2.67562331
125ncRNA catabolic process (GO:0034661)2.67226104
126ncRNA 3-end processing (GO:0043628)2.67021309
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65322182
128histone H4-K12 acetylation (GO:0043983)2.64849413
129regulation of nucleobase-containing compound transport (GO:0032239)2.64828358
130regulation of translation in response to stress (GO:0043555)2.64713681
131protein localization to chromosome (GO:0034502)2.63778013
132mitochondrial DNA metabolic process (GO:0032042)2.61325108
133telomere maintenance (GO:0000723)2.61141479
134negative thymic T cell selection (GO:0045060)2.60349196
135negative regulation of telomerase activity (GO:0051974)2.59666306
136positive regulation of gamma-delta T cell activation (GO:0046645)2.58804791
137cellular protein complex localization (GO:0034629)2.57716995
138regulation of vitamin D biosynthetic process (GO:0060556)2.56976048
139positive T cell selection (GO:0043368)2.56787466
140telomere organization (GO:0032200)2.55291772
141termination of RNA polymerase II transcription (GO:0006369)2.55152431
142ncRNA processing (GO:0034470)2.51985418
143mRNA export from nucleus (GO:0006406)2.50977572
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.50101572
145somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50101572
146regulation of histone H3-K27 methylation (GO:0061085)2.49715964
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.49230986
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48751083
149chromosome condensation (GO:0030261)2.47780952
150DNA ligation (GO:0006266)2.47092215
151transcription elongation from RNA polymerase I promoter (GO:0006362)2.46327189
152negative T cell selection (GO:0043383)2.45310265
153chaperone mediated protein folding requiring cofactor (GO:0051085)2.44800663
154RNA export from nucleus (GO:0006405)2.44243817
155nucleotide salvage (GO:0043173)2.43882895
156TOR signaling (GO:0031929)2.43582560
157base-excision repair (GO:0006284)2.42846490
158RNA methylation (GO:0001510)2.41850557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41824018
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.10885227
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.97200381
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34277715
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27698256
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04711464
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.96954119
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78270463
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63409424
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.47164682
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39184550
12MYC_22102868_ChIP-Seq_BL_Human2.26227643
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15953799
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.13280862
15XRN2_22483619_ChIP-Seq_HELA_Human2.08705246
16* EST1_17652178_ChIP-ChIP_JURKAT_Human2.07179695
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99349643
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93280117
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91706685
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90248428
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.88265705
22AR_21909140_ChIP-Seq_LNCAP_Human1.87352872
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81360471
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78654864
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.78256707
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75714784
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75136425
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74783969
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73512698
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70139363
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68363176
32VDR_23849224_ChIP-Seq_CD4+_Human1.64137649
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62583184
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60839841
35DCP1A_22483619_ChIP-Seq_HELA_Human1.56259312
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56137568
37GABP_19822575_ChIP-Seq_HepG2_Human1.54306702
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54244479
39* KDM5A_27292631_Chip-Seq_BREAST_Human1.53594503
40FOXP3_21729870_ChIP-Seq_TREG_Human1.53528490
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53476374
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.51923951
43TTF2_22483619_ChIP-Seq_HELA_Human1.47450046
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47238084
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46553655
46CIITA_25753668_ChIP-Seq_RAJI_Human1.46282131
47MAF_26560356_Chip-Seq_TH2_Human1.44190546
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40906117
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40802319
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40792526
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40792526
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40792526
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40784382
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38785051
55MYB_26560356_Chip-Seq_TH2_Human1.35413759
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35252149
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35021507
58* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34850853
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33810250
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33600718
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30909579
62MYB_26560356_Chip-Seq_TH1_Human1.30414562
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.29354326
64SPI1_23547873_ChIP-Seq_NB4_Human1.27587622
65SCL_19346495_ChIP-Seq_HPC-7_Human1.26951209
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26629765
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26134083
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25622860
69MAF_26560356_Chip-Seq_TH1_Human1.25316624
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24873269
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24424526
72ZNF263_19887448_ChIP-Seq_K562_Human1.24282905
73* SRF_21415370_ChIP-Seq_HL-1_Mouse1.22679040
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22319183
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22140199
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21847464
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21602902
78VDR_21846776_ChIP-Seq_THP-1_Human1.19925948
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19384038
80* TFEB_21752829_ChIP-Seq_HELA_Human1.18629297
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18626388
82* ELK1_19687146_ChIP-ChIP_HELA_Human1.18193882
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18166689
84UTX_26944678_Chip-Seq_JUKART_Human1.17529325
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16973335
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16937478
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16900620
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.16066171
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.15826111
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.15187562
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14856466
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14350623
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14234297
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12831868
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12027170
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11471239
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10162002
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07708834
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07000448
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06867627
101VDR_24763502_ChIP-Seq_THP-1_Human1.05742958
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04554505
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04160054
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03015106
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01406542
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00995063
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99657118
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98998565
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.98542866
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98534841
111NCOR1_26117541_ChIP-Seq_K562_Human0.98032559
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96944176
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96177395
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95820615
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94162156
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92891957
117ATF3_27146783_Chip-Seq_COLON_Human0.92469429
118* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92239435
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90973521
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90889971
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89725231
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88731423
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88510904
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88452530
125ELK3_25401928_ChIP-Seq_HUVEC_Human0.87563969
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87197561
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85962218
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.85926617
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84208525
130TCF7_22412390_ChIP-Seq_EML_Mouse0.84096644
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.83562937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.33581324
2* MP0003111_abnormal_nucleus_morphology4.06073141
3MP0004957_abnormal_blastocyst_morpholog3.82220603
4MP0010094_abnormal_chromosome_stability3.77211838
5MP0003077_abnormal_cell_cycle3.45385325
6MP0008057_abnormal_DNA_replication3.22425379
7MP0010352_gastrointestinal_tract_polyps3.01318731
8MP0003705_abnormal_hypodermis_morpholog2.90772628
9MP0001661_extended_life_span2.78879100
10MP0003123_paternal_imprinting2.53436196
11* MP0001730_embryonic_growth_arrest2.49352040
12MP0008058_abnormal_DNA_repair2.32067167
13MP0000350_abnormal_cell_proliferation2.31825268
14MP0010307_abnormal_tumor_latency2.22209651
15MP0002396_abnormal_hematopoietic_system2.12352767
16MP0008932_abnormal_embryonic_tissue2.09211994
17MP0005076_abnormal_cell_differentiation2.05190610
18MP0001672_abnormal_embryogenesis/_devel2.00892944
19MP0005380_embryogenesis_phenotype2.00892944
20MP0008007_abnormal_cellular_replicative1.97719617
21MP0001835_abnormal_antigen_presentation1.96782998
22MP0003984_embryonic_growth_retardation1.86881186
23MP0004197_abnormal_fetal_growth/weight/1.84626792
24MP0002254_reproductive_system_inflammat1.84512294
25MP0002088_abnormal_embryonic_growth/wei1.84132210
26MP0001697_abnormal_embryo_size1.82034451
27MP0002086_abnormal_extraembryonic_tissu1.75142355
28MP0001873_stomach_inflammation1.75122068
29MP0002084_abnormal_developmental_patter1.74117076
30* MP0002080_prenatal_lethality1.66207348
31MP0002085_abnormal_embryonic_tissue1.64202429
32MP0005451_abnormal_body_composition1.61406180
33MP0008995_early_reproductive_senescence1.57414322
34MP0001800_abnormal_humoral_immune1.57152280
35MP0003566_abnormal_cell_adhesion1.53642850
36MP0003786_premature_aging1.48843722
37MP0005671_abnormal_response_to1.46438099
38MP0003806_abnormal_nucleotide_metabolis1.44096119
39MP0008877_abnormal_DNA_methylation1.41555435
40MP0003172_abnormal_lysosome_physiology1.40359094
41MP0003567_abnormal_fetal_cardiomyocyte1.38583747
42MP0000490_abnormal_crypts_of1.36546193
43MP0000716_abnormal_immune_system1.33700508
44MP0005023_abnormal_wound_healing1.33237603
45MP0000685_abnormal_immune_system1.32950644
46MP0005387_immune_system_phenotype1.32902658
47MP0001790_abnormal_immune_system1.32902658
48MP0004233_abnormal_muscle_weight1.32029039
49MP0001853_heart_inflammation1.30543176
50MP0003121_genomic_imprinting1.30359881
51MP0002019_abnormal_tumor_incidence1.29558530
52MP0004808_abnormal_hematopoietic_stem1.29548428
53MP0000313_abnormal_cell_death1.29415251
54MP0005000_abnormal_immune_tolerance1.28609756
55MP0002877_abnormal_melanocyte_morpholog1.28583695
56MP0002420_abnormal_adaptive_immunity1.27106772
57MP0002452_abnormal_antigen_presenting1.24656787
58MP0001819_abnormal_immune_cell1.24126359
59MP0000537_abnormal_urethra_morphology1.24033734
60MP0005310_abnormal_salivary_gland1.23389777
61MP0008260_abnormal_autophagy1.23347883
62MP0003890_abnormal_embryonic-extraembry1.20913701
63MP0002723_abnormal_immune_serum1.20770522
64MP0009278_abnormal_bone_marrow1.20048615
65MP0004947_skin_inflammation1.18901898
66MP0009672_abnormal_birth_weight1.17020199
67MP0005220_abnormal_exocrine_pancreas1.16353971
68MP0001849_ear_inflammation1.15484466
69MP0010030_abnormal_orbit_morphology1.15432745
70MP0001915_intracranial_hemorrhage1.14539001
71MP0009333_abnormal_splenocyte_physiolog1.14465113
72MP0004264_abnormal_extraembryonic_tissu1.10441776
73MP0003718_maternal_effect1.09050848
74MP0005360_urolithiasis1.08551205
75MP0001293_anophthalmia1.07780378
76MP0003436_decreased_susceptibility_to1.07326570
77MP0005397_hematopoietic_system_phenotyp1.06019209
78MP0001545_abnormal_hematopoietic_system1.06019209
79MP0000703_abnormal_thymus_morphology1.04964288
80MP0003941_abnormal_skin_development1.03164000
81MP0000015_abnormal_ear_pigmentation1.01986071
82MP0003119_abnormal_digestive_system0.99877901
83MP0009703_decreased_birth_body0.98715377
84MP0003763_abnormal_thymus_physiology0.98315808
85MP0005670_abnormal_white_adipose0.96501934
86MP0005083_abnormal_biliary_tract0.95006517
87MP0005075_abnormal_melanosome_morpholog0.94999614
88MP0001764_abnormal_homeostasis0.93314336
89MP0009053_abnormal_anal_canal0.92999555
90MP0002722_abnormal_immune_system0.92230132
91MP0002006_tumorigenesis0.91383835
92MP0000428_abnormal_craniofacial_morphol0.91253510
93MP0002166_altered_tumor_susceptibility0.91250345
94MP0002148_abnormal_hypersensitivity_rea0.90058068
95MP0002092_abnormal_eye_morphology0.89139026
96MP0005647_abnormal_sex_gland0.88122987
97MP0005464_abnormal_platelet_physiology0.88029019
98MP0000733_abnormal_muscle_development0.87733616
99MP0002419_abnormal_innate_immunity0.86074377
100MP0002398_abnormal_bone_marrow0.85968642
101MP0000689_abnormal_spleen_morphology0.85957712
102MP0005621_abnormal_cell_physiology0.85322328
103MP0002138_abnormal_hepatobiliary_system0.84969490
104MP0003943_abnormal_hepatobiliary_system0.84962366
105MP0000003_abnormal_adipose_tissue0.82359901
106MP0001986_abnormal_taste_sensitivity0.82279474
107MP0002697_abnormal_eye_size0.81989282
108MP0005266_abnormal_metabolism0.81209426
109MP0003221_abnormal_cardiomyocyte_apopto0.80733212
110MP0005384_cellular_phenotype0.80473030
111MP0002111_abnormal_tail_morphology0.79238947
112MP0004133_heterotaxia0.78587348
113MP0002970_abnormal_white_adipose0.77798493
114MP0000372_irregular_coat_pigmentation0.77785513
115MP0005025_abnormal_response_to0.76720227
116MP0000750_abnormal_muscle_regeneration0.76628100
117MP0000569_abnormal_digit_pigmentation0.76330311
118MP0002009_preneoplasia0.75965275
119MP0000013_abnormal_adipose_tissue0.75416205
120MP0000858_altered_metastatic_potential0.75088342
121MP0008770_decreased_survivor_rate0.74889861
122MP0002925_abnormal_cardiovascular_devel0.74425221
123MP0000358_abnormal_cell_content/0.74171265
124MP0002210_abnormal_sex_determination0.73384236
125MP0009840_abnormal_foam_cell0.73031022
126MP0004381_abnormal_hair_follicle0.72437046
127MP0003300_gastrointestinal_ulcer0.71720870
128MP0001145_abnormal_male_reproductive0.71621696
129MP0003453_abnormal_keratinocyte_physiol0.71450808
130MP0002075_abnormal_coat/hair_pigmentati0.71406919
131MP0000598_abnormal_liver_morphology0.70660134
132MP0000477_abnormal_intestine_morphology0.69750265
133MP0002653_abnormal_ependyma_morphology0.68910512
134MP0000371_diluted_coat_color0.68898085
135MP0002938_white_spotting0.67387165
136MP0002429_abnormal_blood_cell0.66591352
137MP0000432_abnormal_head_morphology0.66096571
138MP0003448_altered_tumor_morphology0.65561535
139MP0004185_abnormal_adipocyte_glucose0.63910805
140MP0002269_muscular_atrophy0.61247473
141MP0010234_abnormal_vibrissa_follicle0.60887753
142MP0003937_abnormal_limbs/digits/tail_de0.58695589
143MP0002405_respiratory_system_inflammati0.58434284
144MP0003115_abnormal_respiratory_system0.58429863
145MP0001286_abnormal_eye_development0.57494318
146MP0003091_abnormal_cell_migration0.57403176
147MP0005501_abnormal_skin_physiology0.57306078
148MP0000653_abnormal_sex_gland0.55801285
149MP0000266_abnormal_heart_morphology0.55457103
150MP0001929_abnormal_gametogenesis0.54510271

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)3.73549288
2Reticulocytopenia (HP:0001896)3.59932362
3Ependymoma (HP:0002888)3.55706162
4Birth length less than 3rd percentile (HP:0003561)3.42564745
5Chromsome breakage (HP:0040012)3.34681440
6Colon cancer (HP:0003003)3.22666281
7Multiple enchondromatosis (HP:0005701)3.18855829
8Breast hypoplasia (HP:0003187)3.15066189
9Progressive muscle weakness (HP:0003323)3.11864247
10Abnormality of alanine metabolism (HP:0010916)3.08210818
11Hyperalaninemia (HP:0003348)3.08210818
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08210818
13Abnormality of cells of the erythroid lineage (HP:0012130)3.01296435
14IgA deficiency (HP:0002720)3.01164540
15Panhypogammaglobulinemia (HP:0003139)2.97851050
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96346426
17Abnormal number of erythroid precursors (HP:0012131)2.88964224
18Agammaglobulinemia (HP:0004432)2.87992849
19Microvesicular hepatic steatosis (HP:0001414)2.87557485
20Abnormality of homocysteine metabolism (HP:0010919)2.73379450
21Homocystinuria (HP:0002156)2.73379450
22Colitis (HP:0002583)2.72350409
23Medulloblastoma (HP:0002885)2.72108849
24Deviation of the thumb (HP:0009603)2.69876323
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.69770318
26Missing ribs (HP:0000921)2.69459946
27Progressive external ophthalmoplegia (HP:0000590)2.68304311
28Abnormality of the labia minora (HP:0012880)2.66955898
29Proximal placement of thumb (HP:0009623)2.66948695
30Carpal bone hypoplasia (HP:0001498)2.65964301
31Rhabdomyosarcoma (HP:0002859)2.63528818
32Fatigue (HP:0012378)2.62800914
33Ectopic kidney (HP:0000086)2.58764304
34Recurrent viral infections (HP:0004429)2.58587172
35Patellar aplasia (HP:0006443)2.58141620
36Acute lymphatic leukemia (HP:0006721)2.55245387
37Constricted visual fields (HP:0001133)2.54962476
38Abnormality of the fingertips (HP:0001211)2.48897922
39Pustule (HP:0200039)2.48145312
40Abnormality of subcutaneous fat tissue (HP:0001001)2.47831352
41Abnormality of DNA repair (HP:0003254)2.47529024
42Recurrent fungal infections (HP:0002841)2.47132342
43Absent radius (HP:0003974)2.44170478
44Neoplasm of the adrenal cortex (HP:0100641)2.43459437
45Trismus (HP:0000211)2.42756123
46Impulsivity (HP:0100710)2.42566665
47Astrocytoma (HP:0009592)2.41676416
48Abnormality of the astrocytes (HP:0100707)2.41676416
49Aplasia/Hypoplasia of the patella (HP:0006498)2.41354820
50Abnormality of chromosome stability (HP:0003220)2.39551288
51IgM deficiency (HP:0002850)2.38867392
52Abnormal number of incisors (HP:0011064)2.38402941
53Hypergonadotropic hypogonadism (HP:0000815)2.38286031
54Short chin (HP:0000331)2.36778808
55Autoimmune hemolytic anemia (HP:0001890)2.35619439
56Gastrointestinal inflammation (HP:0004386)2.34656163
57Chronic mucocutaneous candidiasis (HP:0002728)2.30445109
58Recurrent cutaneous fungal infections (HP:0011370)2.30445109
59Abnormality of cochlea (HP:0000375)2.30004531
60Abnormality of T cell physiology (HP:0011840)2.28940449
61Glioma (HP:0009733)2.28509795
62Ureteral duplication (HP:0000073)2.28354986
63Esophageal varix (HP:0002040)2.27565897
64Prominent nose (HP:0000448)2.27253705
65Meckel diverticulum (HP:0002245)2.26559424
66Abnormality of pyrimidine metabolism (HP:0004353)2.24607054
67Aplasia/hypoplasia of the humerus (HP:0006507)2.23258922
6811 pairs of ribs (HP:0000878)2.21513855
69Premature ovarian failure (HP:0008209)2.20819936
70Abnormality of the ileum (HP:0001549)2.20346721
71Aplasia involving forearm bones (HP:0009822)2.19645103
72Absent forearm bone (HP:0003953)2.19645103
73Oral leukoplakia (HP:0002745)2.18603698
74Abnormality of T cells (HP:0002843)2.17585407
75Absent thumb (HP:0009777)2.17380855
76Chronic diarrhea (HP:0002028)2.16580760
77Basal cell carcinoma (HP:0002671)2.16487580
78Petechiae (HP:0000967)2.16361635
79Rough bone trabeculation (HP:0100670)2.14517247
80High pitched voice (HP:0001620)2.14003765
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.13578486
82Abnormality of the anterior horn cell (HP:0006802)2.12604967
83Degeneration of anterior horn cells (HP:0002398)2.12604967
84Macrocytic anemia (HP:0001972)2.12374350
85Cellular immunodeficiency (HP:0005374)2.11997450
86Cheilitis (HP:0100825)2.11715327
87Neoplasm of striated muscle (HP:0009728)2.09969880
88Rib fusion (HP:0000902)2.09196105
89Skull defect (HP:0001362)2.09179518
90Lymphopenia (HP:0001888)2.08948639
91Myelodysplasia (HP:0002863)2.08885091
92Prostate neoplasm (HP:0100787)2.07755173
93Neoplasm of the pancreas (HP:0002894)2.07429704
94Cerebral aneurysm (HP:0004944)2.06710914
95Cerebral hypomyelination (HP:0006808)2.06449239
96Ulnar bowing (HP:0003031)2.05495562
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.05301822
98Viral hepatitis (HP:0006562)2.04925754
99Myocardial infarction (HP:0001658)2.04434985
100Abnormality of the prostate (HP:0008775)2.03533557
101Shawl scrotum (HP:0000049)2.03455913
102Hypopigmentation of the fundus (HP:0007894)2.01375356
103Agnosia (HP:0010524)2.00396915
104Pallor (HP:0000980)2.00301508
105Inflammation of the large intestine (HP:0002037)2.00157314
106Aplasia cutis congenita (HP:0001057)1.99216098
107Abnormality of reticulocytes (HP:0004312)1.99196567
108Supernumerary spleens (HP:0009799)1.96481109
109Increased nuchal translucency (HP:0010880)1.95684587
110Sparse lateral eyebrow (HP:0005338)1.95420105
111Spastic diplegia (HP:0001264)1.94849446
112Anorexia (HP:0002039)1.94097878
113Slender long bone (HP:0003100)1.93167328
114Cafe-au-lait spot (HP:0000957)1.92066197
115Abnormality of the columella (HP:0009929)1.92050920
116Squamous cell carcinoma (HP:0002860)1.91783675
117Abnormality of B cell number (HP:0010975)1.91237596
118Duplicated collecting system (HP:0000081)1.91151854
119Ragged-red muscle fibers (HP:0003200)1.91128672
120Cutis marmorata (HP:0000965)1.90974412
121Leukopenia (HP:0001882)1.90954929
122Preauricular skin tag (HP:0000384)1.90862894
123Short humerus (HP:0005792)1.90536430
124Abnormality of the preputium (HP:0100587)1.90195220
125Abnormality of the carotid arteries (HP:0005344)1.90045894
126IgG deficiency (HP:0004315)1.90026435
127Clubbing of toes (HP:0100760)1.89986641
128Bone marrow hypocellularity (HP:0005528)1.88878709
129Atresia of the external auditory canal (HP:0000413)1.88867496
130Premature graying of hair (HP:0002216)1.88723337
131Granulocytopenia (HP:0001913)1.88336089
132Neoplasm of the oral cavity (HP:0100649)1.87824024
133Volvulus (HP:0002580)1.87119451
134Hypochromic anemia (HP:0001931)1.86367222
135Skin tags (HP:0010609)1.85846451
136Horseshoe kidney (HP:0000085)1.85638830
137Persistence of primary teeth (HP:0006335)1.84861285
138Delayed puberty (HP:0000823)1.84322954
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.82928864
140Vertebral fusion (HP:0002948)1.82474102
141Abnormality of the lower motor neuron (HP:0002366)1.81859228
142Tracheoesophageal fistula (HP:0002575)1.81622635
143Long eyelashes (HP:0000527)1.81372598
144Increased density of long bones (HP:0006392)1.81208237
145Polygenic inheritance (HP:0010982)1.80311862
146Nephroblastoma (Wilms tumor) (HP:0002667)1.79635902
147Pelvic girdle muscle weakness (HP:0003749)1.79343465
148Spontaneous hematomas (HP:0007420)1.79291473
149Arteriovenous malformation (HP:0100026)1.78795565
150Protrusio acetabuli (HP:0003179)1.78572863
151Micronodular cirrhosis (HP:0001413)1.77767385
152Supernumerary ribs (HP:0005815)1.77721749
153Abnormality of the calcaneus (HP:0008364)1.77175431
154Anal stenosis (HP:0002025)1.76875980
155Supernumerary bones of the axial skeleton (HP:0009144)1.76860081
156Abnormal umbilical cord blood vessels (HP:0011403)1.76790064
157Single umbilical artery (HP:0001195)1.76790064
158Abnormality of the fetal cardiovascular system (HP:0010948)1.76790064
159Sloping forehead (HP:0000340)1.76742316
160Urethral obstruction (HP:0000796)1.76505031
161Deep palmar crease (HP:0006191)1.75089019
162Hemoptysis (HP:0002105)1.74906266
163Duodenal stenosis (HP:0100867)1.74751212
164Small intestinal stenosis (HP:0012848)1.74751212
165Hand muscle atrophy (HP:0009130)1.74550884
166Biconcave vertebral bodies (HP:0004586)1.73904130
167Gastrointestinal carcinoma (HP:0002672)1.73751652
168Malignant gastrointestinal tract tumors (HP:0006749)1.73751652
169Short palpebral fissure (HP:0012745)1.73558599
170Biliary tract neoplasm (HP:0100574)1.72974099
171Short 1st metacarpal (HP:0010034)1.72354242
172Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72354242
173Hepatitis (HP:0012115)1.71298112
174Secondary amenorrhea (HP:0000869)1.71067244
175Amaurosis fugax (HP:0100576)1.70848907
176Acute myeloid leukemia (HP:0004808)1.69893397
177Short thumb (HP:0009778)1.69025759
178Spinal muscular atrophy (HP:0007269)1.68142658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.00143448
2CDC73.61487996
3SCYL23.29492629
4WEE13.02690236
5NEK22.92844585
6SMG12.80361214
7SRPK12.68388344
8BUB12.58987261
9EEF2K2.52745344
10TTK2.35552014
11MAP3K102.33414979
12TSSK62.09405008
13PKN21.90328028
14EPHA21.81950015
15RPS6KB21.77646215
16PLK11.75602466
17CDK41.72876839
18STK101.68026711
19IRAK31.66381580
20ALK1.65300893
21TLK11.63100065
22EIF2AK11.62767667
23CDK71.57647735
24MAP3K81.52535504
25TRIB31.52530779
26MAP2K31.49167981
27PASK1.46834191
28ATR1.44247935
29NEK11.44042440
30MAP4K11.36780596
31ITK1.36279718
32MAP3K141.35727079
33PLK41.35632896
34AURKB1.35287209
35RPS6KA41.34940709
36NME21.31047019
37STK31.30265028
38LATS11.27281408
39BRD41.25719693
40CHEK11.25627838
41CHEK21.25543637
42TTN1.23770149
43MTOR1.22980171
44MAPK111.15355395
45DYRK31.15049929
46PLK31.14960631
47FGFR41.14687864
48BRSK21.14681161
49LATS21.14114234
50PRPF4B1.13474208
51NME11.10834115
52PAK41.10026299
53TGFBR11.06108063
54PIM11.06020312
55ZAK1.04160654
56LRRK21.03869310
57FGR1.03532131
58RIPK41.03433722
59BTK1.01811968
60TEC1.01297219
61MARK30.98576524
62CDK20.98379264
63TXK0.98281444
64ATM0.94204924
65MAP3K130.93488772
66MKNK10.90870740
67CDK60.90491365
68EIF2AK30.89562241
69STK40.89485962
70AURKA0.89389140
71PTK60.87725545
72IKBKB0.86548196
73TESK20.86031616
74MELK0.81944988
75CDC42BPA0.81665244
76PAK20.81539143
77PDK20.81325421
78ACVR1B0.81220152
79VRK20.80467603
80BMX0.78359595
81NUAK10.76594618
82PNCK0.75718311
83FGFR30.72020527
84CLK10.69351330
85RPS6KA10.68976109
86VRK10.66473483
87CSNK2A20.65084273
88KIT0.63332577
89TAOK20.63280091
90STK160.63170725
91ICK0.62769309
92CSNK1E0.62125964
93CDK10.61922069
94GRK60.61073366
95TBK10.60488092
96IRAK20.59706905
97CCNB10.59563274
98IKBKE0.59089014
99AKT20.59075353
100MAP3K30.59037725
101ERN10.58360872
102LCK0.57945190
103MAPKAPK50.56304520
104MKNK20.56290410
105FLT30.55205445
106HIPK20.54765586
107SYK0.53566027
108JAK30.53130652
109ZAP700.52326187
110AKT30.51659670
111PAK10.51592798
112TNK20.49951399
113KDR0.49751908
114RAF10.48606619
115MAP3K110.48283731
116PDGFRA0.47823408
117CAMK1D0.47302861
118CDK80.47090654
119PRKDC0.46593000
120CSNK1D0.45141024
121TAF10.43718377
122RPS6KL10.43424479
123RPS6KC10.43424479
124MAPKAPK30.43144289
125STK38L0.42203933
126CSNK2A10.42165253
127CDK90.42010288
128CHUK0.41588026
129DAPK10.41032624
130RPS6KB10.40473507
131YES10.39732203
132TRPM70.39110815
133GSK3B0.39094205
134BRSK10.38274625
135MAP2K20.36605812
136MAP2K60.35200008
137PRKCI0.34802991
138MAPK140.34428127
139RPS6KA50.33953743
140CSF1R0.33209555
141BCKDK0.32833760
142MAPK10.31932419
143TAOK10.31686630
144TYK20.30803151
145PIM20.30242657

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.00159653
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.86685584
3One carbon pool by folate_Homo sapiens_hsa006703.57102955
4RNA transport_Homo sapiens_hsa030133.46278597
5Mismatch repair_Homo sapiens_hsa034303.18726376
6Spliceosome_Homo sapiens_hsa030403.05713019
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71509490
8RNA polymerase_Homo sapiens_hsa030202.68252040
9Ribosome_Homo sapiens_hsa030102.59206221
10Base excision repair_Homo sapiens_hsa034102.50611965
11Homologous recombination_Homo sapiens_hsa034402.46790714
12Cell cycle_Homo sapiens_hsa041102.41722884
13Nucleotide excision repair_Homo sapiens_hsa034201.97097433
14mRNA surveillance pathway_Homo sapiens_hsa030151.94085549
15Pyrimidine metabolism_Homo sapiens_hsa002401.93631321
16Other glycan degradation_Homo sapiens_hsa005111.93231036
17Asthma_Homo sapiens_hsa053101.87042503
18Non-homologous end-joining_Homo sapiens_hsa034501.84330197
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.82916878
20Fanconi anemia pathway_Homo sapiens_hsa034601.77578549
21Allograft rejection_Homo sapiens_hsa053301.74275885
22p53 signaling pathway_Homo sapiens_hsa041151.72242835
23Proteasome_Homo sapiens_hsa030501.65390598
24RNA degradation_Homo sapiens_hsa030181.64145907
25Autoimmune thyroid disease_Homo sapiens_hsa053201.61104781
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.58490640
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41920351
28Graft-versus-host disease_Homo sapiens_hsa053321.31907419
29Selenocompound metabolism_Homo sapiens_hsa004501.31287229
30Systemic lupus erythematosus_Homo sapiens_hsa053221.29532670
31Biosynthesis of amino acids_Homo sapiens_hsa012301.29025811
32Viral carcinogenesis_Homo sapiens_hsa052031.26032287
33Epstein-Barr virus infection_Homo sapiens_hsa051691.22523320
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.20795950
35Type I diabetes mellitus_Homo sapiens_hsa049401.15581430
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13201479
37Basal transcription factors_Homo sapiens_hsa030221.09632390
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06753129
39Sulfur relay system_Homo sapiens_hsa041221.05817114
40Folate biosynthesis_Homo sapiens_hsa007900.99433004
41Antigen processing and presentation_Homo sapiens_hsa046120.99269897
42Small cell lung cancer_Homo sapiens_hsa052220.99242414
43MicroRNAs in cancer_Homo sapiens_hsa052060.94082360
44Herpes simplex infection_Homo sapiens_hsa051680.93872994
45HTLV-I infection_Homo sapiens_hsa051660.93161494
46Vitamin B6 metabolism_Homo sapiens_hsa007500.92014726
47Lysine degradation_Homo sapiens_hsa003100.91220649
48Purine metabolism_Homo sapiens_hsa002300.90733402
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82505536
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.82195657
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81766579
52Leishmaniasis_Homo sapiens_hsa051400.81256171
53Chronic myeloid leukemia_Homo sapiens_hsa052200.78540946
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78455835
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78398772
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74298311
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73668279
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72278278
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.72270698
60T cell receptor signaling pathway_Homo sapiens_hsa046600.71907277
61Sulfur metabolism_Homo sapiens_hsa009200.70494757
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69684093
63Apoptosis_Homo sapiens_hsa042100.68915469
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.68284263
65Oocyte meiosis_Homo sapiens_hsa041140.67890849
66Hippo signaling pathway_Homo sapiens_hsa043900.66588020
67Carbon metabolism_Homo sapiens_hsa012000.64748067
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64209868
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63471517
70Pentose phosphate pathway_Homo sapiens_hsa000300.63449322
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62661709
72Notch signaling pathway_Homo sapiens_hsa043300.62139253
73Hematopoietic cell lineage_Homo sapiens_hsa046400.62039941
74Rheumatoid arthritis_Homo sapiens_hsa053230.61970952
75TGF-beta signaling pathway_Homo sapiens_hsa043500.61410308
76Legionellosis_Homo sapiens_hsa051340.61332676
77Thyroid cancer_Homo sapiens_hsa052160.61046889
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.60872326
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59168677
80Acute myeloid leukemia_Homo sapiens_hsa052210.58177090
81Bladder cancer_Homo sapiens_hsa052190.57661321
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55887074
83mTOR signaling pathway_Homo sapiens_hsa041500.54818649
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54055296
85TNF signaling pathway_Homo sapiens_hsa046680.50770818
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48840037
87Hepatitis B_Homo sapiens_hsa051610.48778091
88Adherens junction_Homo sapiens_hsa045200.48549857
89Fructose and mannose metabolism_Homo sapiens_hsa000510.48097492
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47720539
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47450332
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45051749
93Colorectal cancer_Homo sapiens_hsa052100.44879951
94Basal cell carcinoma_Homo sapiens_hsa052170.44693810
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44109681
96HIF-1 signaling pathway_Homo sapiens_hsa040660.43569893
97ABC transporters_Homo sapiens_hsa020100.39077223
98Proteoglycans in cancer_Homo sapiens_hsa052050.38510339
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38264250
100Prolactin signaling pathway_Homo sapiens_hsa049170.37628279
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37015527
102Viral myocarditis_Homo sapiens_hsa054160.36980896
103Prostate cancer_Homo sapiens_hsa052150.36516449
104Measles_Homo sapiens_hsa051620.36515933
105Staphylococcus aureus infection_Homo sapiens_hsa051500.34765686
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34092442
107Influenza A_Homo sapiens_hsa051640.33602813
108Shigellosis_Homo sapiens_hsa051310.33184454
109Pathways in cancer_Homo sapiens_hsa052000.32132425
110African trypanosomiasis_Homo sapiens_hsa051430.31347552
111Primary immunodeficiency_Homo sapiens_hsa053400.30532687
112Tuberculosis_Homo sapiens_hsa051520.30056102
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29316750
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28803745
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28052866
116Non-small cell lung cancer_Homo sapiens_hsa052230.27456181
117B cell receptor signaling pathway_Homo sapiens_hsa046620.27176247
118Glutathione metabolism_Homo sapiens_hsa004800.25600249
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24912398
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24443964
121Arginine and proline metabolism_Homo sapiens_hsa003300.24162501
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23695140
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23267348
124N-Glycan biosynthesis_Homo sapiens_hsa005100.23208109
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22607488
126Galactose metabolism_Homo sapiens_hsa000520.22135693
127Pancreatic cancer_Homo sapiens_hsa052120.22008097
128Toxoplasmosis_Homo sapiens_hsa051450.21257915
129Alcoholism_Homo sapiens_hsa050340.21133582
130FoxO signaling pathway_Homo sapiens_hsa040680.19764837
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.19158661
132Vitamin digestion and absorption_Homo sapiens_hsa049770.18980886

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