RBM20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds RNA and regulates splicing. Mutations in this gene have been associated with familial dilated cardiomyopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.38329099
2cardiac myofibril assembly (GO:0055003)8.79320673
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.07886070
4myofibril assembly (GO:0030239)7.78148953
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.35641073
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.25047951
7tooth mineralization (GO:0034505)7.23759963
8detection of chemical stimulus involved in sensory perception of smell (GO:0050911)7.20087545
9muscle filament sliding (GO:0030049)6.97537744
10actin-myosin filament sliding (GO:0033275)6.97537744
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.93459848
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.76789193
13cardiac muscle cell development (GO:0055013)6.76286103
14cardiac muscle contraction (GO:0060048)6.73561175
15activation of protein kinase A activity (GO:0034199)6.51086176
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.38214140
17cardiac cell development (GO:0055006)6.35176894
18ventricular cardiac muscle cell action potential (GO:0086005)6.10667693
19regulation of actin filament-based movement (GO:1903115)6.06195810
20bundle of His cell to Purkinje myocyte communication (GO:0086069)5.96989692
21regulation of relaxation of muscle (GO:1901077)5.96968211
22plasma membrane repair (GO:0001778)5.95907289
23adult heart development (GO:0007512)5.94497743
24cardiac muscle tissue morphogenesis (GO:0055008)5.90931400
25actomyosin structure organization (GO:0031032)5.90642635
26regulation of skeletal muscle contraction (GO:0014819)5.85923336
27tricarboxylic acid cycle (GO:0006099)5.85770498
28actin-mediated cell contraction (GO:0070252)5.82770970
29protein K11-linked deubiquitination (GO:0035871)5.75488685
30ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.73616470
31cardiac muscle hypertrophy (GO:0003300)5.71728672
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.59045788
33regulation of sarcomere organization (GO:0060297)5.44770870
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.41927602
35striated muscle hypertrophy (GO:0014897)5.41570887
36negative regulation of T-helper cell differentiation (GO:0045623)5.40463206
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.40463206
38cilium or flagellum-dependent cell motility (GO:0001539)5.32757080
39muscle tissue morphogenesis (GO:0060415)5.30678864
40cAMP biosynthetic process (GO:0006171)5.30362282
41seminiferous tubule development (GO:0072520)5.30092027
42striated muscle contraction (GO:0006941)5.26887317
43cell communication involved in cardiac conduction (GO:0086065)5.22586475
44regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.18575438
45carnitine shuttle (GO:0006853)5.17637360
46regulation of striated muscle contraction (GO:0006942)5.07137378
47positive regulation of protein sumoylation (GO:0033235)5.04498820
48heart trabecula formation (GO:0060347)5.03289045
49sarcoplasmic reticulum calcium ion transport (GO:0070296)5.00341153
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.88926731
51regulation of the force of heart contraction (GO:0002026)4.87628334
52regulation of membrane repolarization (GO:0060306)4.83570145
53regulation of cell communication by electrical coupling (GO:0010649)4.82813789
54muscle hypertrophy (GO:0014896)4.76488590
55axonemal dynein complex assembly (GO:0070286)4.70667596
56cell communication by electrical coupling (GO:0010644)4.70253969
57detection of chemical stimulus involved in sensory perception (GO:0050907)4.56871055
58heart contraction (GO:0060047)4.49051028
59heart process (GO:0003015)4.49051028
60actin filament-based movement (GO:0030048)4.45913238
61fatty acid transmembrane transport (GO:1902001)4.45342908
62regulation of acyl-CoA biosynthetic process (GO:0050812)4.41796571
63cardiac muscle cell action potential (GO:0086001)4.38455385
64regulation of cardiac muscle contraction (GO:0055117)4.36423556
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.33370004
66cardiac muscle cell action potential involved in contraction (GO:0086002)4.31571633
67negative regulation of cytosolic calcium ion concentration (GO:0051481)4.31080377
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.26096231
69regulation of cardiac muscle cell contraction (GO:0086004)4.25824624
70enteric nervous system development (GO:0048484)4.24592663
71righting reflex (GO:0060013)4.21730348
72response to caffeine (GO:0031000)4.20967430
73negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.15107262
74regulation of heart rate (GO:0002027)4.14666762
75regulation of T-helper 1 cell differentiation (GO:0045625)4.12396075
76negative regulation of alpha-beta T cell differentiation (GO:0046639)4.08753011
77relaxation of cardiac muscle (GO:0055119)4.08174405
78negative regulation of type 2 immune response (GO:0002829)4.07110763
79regulation of coenzyme metabolic process (GO:0051196)4.05275594
80regulation of cofactor metabolic process (GO:0051193)4.05275594
81regulation of cardioblast differentiation (GO:0051890)4.04962432
82negative regulation of potassium ion transport (GO:0043267)4.00752536
83dendritic spine morphogenesis (GO:0060997)3.99058823
84negative regulation of striated muscle cell apoptotic process (GO:0010664)3.97114890
85cardiac muscle hypertrophy in response to stress (GO:0014898)3.92486375
86muscle hypertrophy in response to stress (GO:0003299)3.92486375
87cardiac muscle adaptation (GO:0014887)3.92486375
88positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.89588220
89regulation of T-helper 2 cell differentiation (GO:0045628)3.86907900
90striated muscle cell development (GO:0055002)3.85540008
91motile cilium assembly (GO:0044458)3.82302193
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79598204
93carnitine transmembrane transport (GO:1902603)3.78710482
94regulation of ATP catabolic process (GO:1903289)3.77537541
95regulation of ATPase activity (GO:0043462)3.77537541
96negative regulation of protein localization to cell surface (GO:2000009)3.77106662
97regulation of heart contraction (GO:0008016)3.75959130
98cardiac conduction (GO:0061337)3.75560398
99skeletal muscle contraction (GO:0003009)3.75435363
100ventricular cardiac muscle cell development (GO:0055015)3.73929903
101cardiac ventricle formation (GO:0003211)3.66471362
102regulation of heart rate by cardiac conduction (GO:0086091)3.62699775
103positive regulation of mitochondrial fission (GO:0090141)3.60569495
104cilium movement (GO:0003341)3.54628156
1052-oxoglutarate metabolic process (GO:0006103)3.52592127
106mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51911738
107detection of chemical stimulus (GO:0009593)3.51123401
108positive regulation of cation channel activity (GO:2001259)3.47139040
109muscle contraction (GO:0006936)3.44485465
110amino-acid betaine transport (GO:0015838)3.44332685
111carnitine transport (GO:0015879)3.44332685
112response to inactivity (GO:0014854)3.40825262
113positive regulation of heart rate (GO:0010460)3.40323597
114positive regulation of heart contraction (GO:0045823)3.36543435
115regulation of calcium ion transmembrane transporter activity (GO:1901019)3.33652853
116regulation of calcium ion transmembrane transport (GO:1903169)3.33652853
117detection of calcium ion (GO:0005513)3.33138392
118phosphatidylinositol acyl-chain remodeling (GO:0036149)3.32333823
119muscle cell development (GO:0055001)3.32311086
120regulation of sulfur metabolic process (GO:0042762)3.32296609
121creatine metabolic process (GO:0006600)3.31785719
122NADH metabolic process (GO:0006734)3.31705386
123striated muscle adaptation (GO:0014888)3.31518244
124regulation of muscle contraction (GO:0006937)3.30862019
125cardiac chamber formation (GO:0003207)3.28715994
126trabecula formation (GO:0060343)3.28662371
127energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26078224
128ATP synthesis coupled proton transport (GO:0015986)3.26078224
129muscle system process (GO:0003012)3.25162291
130positive regulation of potassium ion transmembrane transport (GO:1901381)3.19569428
131left/right axis specification (GO:0070986)3.15241055
132endothelial cell differentiation (GO:0045446)3.13889921
133synaptic transmission, dopaminergic (GO:0001963)3.11917678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.92735557
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.60850444
3EP300_21415370_ChIP-Seq_HL-1_Mouse5.30288683
4VDR_22108803_ChIP-Seq_LS180_Human4.60734421
5* TBX20_22328084_ChIP-Seq_HEART_Mouse4.22846030
6* TBX20_22080862_ChIP-Seq_HEART_Mouse4.22846030
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.19235348
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.78950604
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.50954848
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.42009204
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.26809494
12ZNF263_19887448_ChIP-Seq_K562_Human3.16783575
13IGF1R_20145208_ChIP-Seq_DFB_Human3.13712185
14AR_21572438_ChIP-Seq_LNCaP_Human2.90024857
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.53662509
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.49352395
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49013479
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47519773
19GATA4_21415370_ChIP-Seq_HL-1_Mouse2.43596074
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35868874
21* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32695921
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30221963
23GBX2_23144817_ChIP-Seq_PC3_Human2.26582312
24EZH2_22144423_ChIP-Seq_EOC_Human2.25065496
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.16056460
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91912625
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86142959
28NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.81947205
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73728439
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73728439
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67932993
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.65976297
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.65016341
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64691578
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.63143685
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62366522
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59099271
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57901941
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55093565
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.54804486
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53417824
42CLOCK_20551151_ChIP-Seq_293T_Human1.52891645
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.50361101
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50345858
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.50284596
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.49012584
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48753460
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48570230
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46448467
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46401034
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46392298
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45756843
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45380019
54* SMAD3_21741376_ChIP-Seq_EPCs_Human1.44405986
55ER_23166858_ChIP-Seq_MCF-7_Human1.39719048
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39620970
57DROSHA_22980978_ChIP-Seq_HELA_Human1.39306236
58* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38020328
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35651010
60* STAT3_23295773_ChIP-Seq_U87_Human1.34559962
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33867162
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33547325
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33422960
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.30845460
65* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30503202
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29769907
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29253788
68* RNF2_27304074_Chip-Seq_ESCs_Mouse1.28648921
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28559920
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.28455024
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28389720
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27768158
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26158673
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25172966
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.22206124
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21930023
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20394814
78GATA1_19941826_ChIP-Seq_K562_Human1.20194044
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19708020
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19617129
81* TBL1_22424771_ChIP-Seq_293T_Human1.19217326
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19001244
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18857347
84PHF8_20622853_ChIP-Seq_HELA_Human1.17947469
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.17776430
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17375629
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.15037228
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.14860905
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.14788158
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14645014
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.14196776
92FUS_26573619_Chip-Seq_HEK293_Human1.14132760
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13903330
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13797530
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.13337275
96KDM2B_26808549_Chip-Seq_DND41_Human1.13021469
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12686060
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12060648
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11134577
100* HNFA_21074721_ChIP-Seq_CACO-2_Human1.11017667
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10015001
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09174208
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08862097
104CBP_20019798_ChIP-Seq_JUKART_Human1.08449161
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08449161
106TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08090370
107NFYB_21822215_ChIP-Seq_K562_Human1.07835350
108CJUN_26792858_Chip-Seq_BT549_Human1.06628475
109CTCF_27219007_Chip-Seq_Bcells_Human1.06373989
110P300_19829295_ChIP-Seq_ESCs_Human1.06116467
111* TP63_22573176_ChIP-Seq_HFKS_Human1.06087429
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.05889153
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05813759
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05290282
115TCF4_23295773_ChIP-Seq_U87_Human1.05054899
116* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04450405
117ETV1_20927104_ChIP-Seq_GIST48_Human1.01452787
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.01442513
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.00521327
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00160582
121* FOXA2_19822575_ChIP-Seq_HepG2_Human1.00003002
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99832140
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99228264
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99012613
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98798580
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98782630
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98677085
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.98458706
129TCF4_22108803_ChIP-Seq_LS180_Human0.98353488
130* SMAD4_21741376_ChIP-Seq_EPCs_Human0.98306588
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98303237
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97814916
133RACK7_27058665_Chip-Seq_MCF-7_Human0.97807332
134NANOG_19829295_ChIP-Seq_ESCs_Human0.97418911
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.96662574
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96015316
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95621299
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95238279
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.94844465
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94030489
141TP53_16413492_ChIP-PET_HCT116_Human0.93599215
142TP53_23651856_ChIP-Seq_MEFs_Mouse0.91791076
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90785490
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.89347718
145GATA2_19941826_ChIP-Seq_K562_Human0.89170968
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.87086348
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85848210
148ZNF274_21170338_ChIP-Seq_K562_Hela0.85437856
149AHR_22903824_ChIP-Seq_MCF-7_Human0.85142518
150LXR_22292898_ChIP-Seq_THP-1_Human0.84954858
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84859091
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83847029
153BCAT_22108803_ChIP-Seq_LS180_Human0.83112794
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82921129
155* ATF3_27146783_Chip-Seq_COLON_Human0.81530569
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80455627
157WT1_19549856_ChIP-ChIP_CCG9911_Human0.80405586
158TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79026427
159KDM2B_26808549_Chip-Seq_K562_Human0.76860955
160* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76314899
161SPI1_20517297_ChIP-Seq_HL60_Human0.75747196
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.74825720
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74742322
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.74076451
165SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73945179
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.73772162
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73608617
168RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73250357
169EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73250357
170* SPI1_23127762_ChIP-Seq_K562_Human0.71822673
171* EZH2_27304074_Chip-Seq_ESCs_Mouse0.71420816
172UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.71240543
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71117726
174ESR1_21235772_ChIP-Seq_MCF-7_Human0.70222776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.69079292
2MP0004084_abnormal_cardiac_muscle5.97876975
3MP0000751_myopathy5.24419481
4MP0005084_abnormal_gallbladder_morpholo5.15669463
5MP0003646_muscle_fatigue5.15387049
6MP0004215_abnormal_myocardial_fiber5.04330804
7MP0004036_abnormal_muscle_relaxation4.21739814
8MP0005330_cardiomyopathy3.92695646
9MP0000749_muscle_degeneration3.81321400
10MP0002972_abnormal_cardiac_muscle3.24023517
11MP0003137_abnormal_impulse_conducting3.15264130
12MP0004087_abnormal_muscle_fiber3.15156860
13MP0008775_abnormal_heart_ventricle3.10695692
14MP0000750_abnormal_muscle_regeneration2.92858709
15MP0010630_abnormal_cardiac_muscle2.74286118
16MP0005620_abnormal_muscle_contractility2.73824031
17MP0005385_cardiovascular_system_phenoty2.64013904
18MP0001544_abnormal_cardiovascular_syste2.64013904
19MP0002106_abnormal_muscle_physiology2.57556035
20MP0004484_altered_response_of2.42067324
21MP0006138_congestive_heart_failure2.39368910
22MP0004130_abnormal_muscle_cell2.35863537
23MP0003828_pulmonary_edema2.33343793
24MP0004145_abnormal_muscle_electrophysio2.32145222
25MP0002269_muscular_atrophy2.30865452
26MP0004085_abnormal_heartbeat2.17654148
27MP0004510_myositis2.08830664
28MP0005369_muscle_phenotype2.07347841
29MP0003221_abnormal_cardiomyocyte_apopto2.03381805
30MP0000747_muscle_weakness1.94871244
31MP0000759_abnormal_skeletal_muscle1.92470191
32MP0002127_abnormal_cardiovascular_syste1.87216306
33MP0003950_abnormal_plasma_membrane1.84049828
34MP0004233_abnormal_muscle_weight1.84000154
35MP0004133_heterotaxia1.80817874
36MP0003567_abnormal_fetal_cardiomyocyte1.63706131
37MP0003252_abnormal_bile_duct1.57429186
38MP0006036_abnormal_mitochondrial_physio1.39101625
39MP0002928_abnormal_bile_duct1.34647663
40MP0005666_abnormal_adipose_tissue1.31590573
41MP0005670_abnormal_white_adipose1.27771381
42MP0002332_abnormal_exercise_endurance1.27374190
43MP0000266_abnormal_heart_morphology1.20673886
44MP0010368_abnormal_lymphatic_system1.20283495
45MP0002234_abnormal_pharynx_morphology1.09983127
46MP0005165_increased_susceptibility_to1.06170398
47MP0003279_aneurysm1.05646364
48MP0002751_abnormal_autonomic_nervous1.02966997
49MP0003566_abnormal_cell_adhesion1.01451315
50MP0005623_abnormal_meninges_morphology1.00238734
51MP0001270_distended_abdomen0.99198196
52MP0001529_abnormal_vocalization0.98211918
53MP0004264_abnormal_extraembryonic_tissu0.97171118
54MP0002638_abnormal_pupillary_reflex0.95727222
55MP0005448_abnormal_energy_balance0.95307035
56MP0000343_altered_response_to0.93848569
57MP0006035_abnormal_mitochondrial_morpho0.89952258
58MP0002108_abnormal_muscle_morphology0.89882302
59MP0002102_abnormal_ear_morphology0.88058237
60MP0001984_abnormal_olfaction0.87244656
61MP0002128_abnormal_blood_circulation0.87058046
62MP0004185_abnormal_adipocyte_glucose0.86529694
63MP0005375_adipose_tissue_phenotype0.86150526
64MP0005646_abnormal_pituitary_gland0.85999325
65MP0003705_abnormal_hypodermis_morpholog0.84601381
66MP0005253_abnormal_eye_physiology0.83406898
67MP0000733_abnormal_muscle_development0.82267251
68MP0005408_hypopigmentation0.81383677
69MP0001879_abnormal_lymphatic_vessel0.81286734
70MP0002822_catalepsy0.77384698
71MP0003136_yellow_coat_color0.76833265
72MP0001661_extended_life_span0.76185381
73MP0008875_abnormal_xenobiotic_pharmacok0.75426583
74MP0005220_abnormal_exocrine_pancreas0.75159246
75MP0005551_abnormal_eye_electrophysiolog0.72511560
76MP0002160_abnormal_reproductive_system0.70125370
77MP0000767_abnormal_smooth_muscle0.69039577
78MP0005266_abnormal_metabolism0.66134634
79MP0000230_abnormal_systemic_arterial0.65430926
80MP0004272_abnormal_basement_membrane0.64342232
81MP0005379_endocrine/exocrine_gland_phen0.63343965
82MP0008569_lethality_at_weaning0.62217572
83MP0005187_abnormal_penis_morphology0.61180756
84MP0000372_irregular_coat_pigmentation0.60442591
85MP0002572_abnormal_emotion/affect_behav0.60389709
86MP0006276_abnormal_autonomic_nervous0.58541321
87MP0009384_cardiac_valve_regurgitation0.57625304
88MP0005451_abnormal_body_composition0.56662014
89MP0002925_abnormal_cardiovascular_devel0.54580391
90MP0004043_abnormal_pH_regulation0.53160144
91MP0003943_abnormal_hepatobiliary_system0.52635603
92MP0002653_abnormal_ependyma_morphology0.52419963
93MP0000569_abnormal_digit_pigmentation0.51858690
94MP0001986_abnormal_taste_sensitivity0.51757018
95MP0001485_abnormal_pinna_reflex0.51192669
96MP0003045_fibrosis0.50275987
97MP0003984_embryonic_growth_retardation0.50175829
98MP0002088_abnormal_embryonic_growth/wei0.49126189
99MP0002876_abnormal_thyroid_physiology0.49119914
100MP0000003_abnormal_adipose_tissue0.48130850
101MP0002971_abnormal_brown_adipose0.46951373
102MP0005503_abnormal_tendon_morphology0.46480941
103MP0005386_behavior/neurological_phenoty0.45852612
104MP0009745_abnormal_behavioral_response0.45717781
105MP0001784_abnormal_fluid_regulation0.45546179
106MP0005083_abnormal_biliary_tract0.44146296
107MP0005319_abnormal_enzyme/_coenzyme0.43378092
108MP0002909_abnormal_adrenal_gland0.42026228
109MP0001614_abnormal_blood_vessel0.41348361
110MP0002877_abnormal_melanocyte_morpholog0.41189183
111MP0001944_abnormal_pancreas_morphology0.40885038
112MP0003953_abnormal_hormone_level0.40549341
113MP0008438_abnormal_cutaneous_collagen0.40431721
114MP0002735_abnormal_chemical_nociception0.39472212
115MP0002249_abnormal_larynx_morphology0.38586085
116MP0000013_abnormal_adipose_tissue0.38144434
117MP0000631_abnormal_neuroendocrine_gland0.37717609
118MP0005275_abnormal_skin_tensile0.37501498
119MP0002078_abnormal_glucose_homeostasis0.37418203
120MP0003878_abnormal_ear_physiology0.36911327
121MP0005377_hearing/vestibular/ear_phenot0.36911327
122MP0008789_abnormal_olfactory_epithelium0.36753082
123MP0003806_abnormal_nucleotide_metabolis0.36635088
124MP0000049_abnormal_middle_ear0.34999704
125MP0002163_abnormal_gland_morphology0.34858462
126MP0008961_abnormal_basal_metabolism0.33092484
127MP0002295_abnormal_pulmonary_circulatio0.32405704
128MP0009780_abnormal_chondrocyte_physiolo0.31968701
129MP0005380_embryogenesis_phenotype0.30794246
130MP0001672_abnormal_embryogenesis/_devel0.30794246
131MP0001727_abnormal_embryo_implantation0.28590026
132MP0003948_abnormal_gas_homeostasis0.28469638
133MP0000579_abnormal_nail_morphology0.23838099
134MP0006072_abnormal_retinal_apoptosis0.21396531
135MP0009115_abnormal_fat_cell0.20590123
136MP0003385_abnormal_body_wall0.20153617
137MP0005595_abnormal_vascular_smooth0.19431164
138MP0003935_abnormal_craniofacial_develop0.19189595
139MP0005334_abnormal_fat_pad0.18854986
140MP0004147_increased_porphyrin_level0.18481862
141MP0002970_abnormal_white_adipose0.17067966
142MP0001299_abnormal_eye_distance/0.16901596
143MP0004924_abnormal_behavior0.16823689

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.92737003
2Ventricular tachycardia (HP:0004756)7.20342835
3Atrial fibrillation (HP:0005110)6.46102859
4Calf muscle hypertrophy (HP:0008981)6.33749616
5Primary atrial arrhythmia (HP:0001692)6.03786304
6Muscle fiber splitting (HP:0003555)5.94986835
7Supraventricular tachycardia (HP:0004755)5.82850113
8Muscle hypertrophy of the lower extremities (HP:0008968)5.76253176
9Supraventricular arrhythmia (HP:0005115)5.72321504
10Abnormality of the calf musculature (HP:0001430)5.66514427
11Right ventricular cardiomyopathy (HP:0011663)5.62231678
12Exercise-induced muscle cramps (HP:0003710)5.61504251
13* Lipoatrophy (HP:0100578)5.46809759
14Syncope (HP:0001279)5.45573640
15Subaortic stenosis (HP:0001682)5.42415764
16Abnormality of the left ventricular outflow tract (HP:0011103)5.42415764
17Exercise-induced myalgia (HP:0003738)5.36321417
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.29906111
19Hyporeflexia of lower limbs (HP:0002600)5.04992201
20Prolonged QT interval (HP:0001657)4.72123617
21Bundle branch block (HP:0011710)4.55630295
22Myoglobinuria (HP:0002913)4.52382991
23* Dilated cardiomyopathy (HP:0001644)4.52256850
24Ventricular arrhythmia (HP:0004308)4.51019028
25Palpitations (HP:0001962)4.46915106
26EMG: myopathic abnormalities (HP:0003458)4.29486716
27Asymmetric septal hypertrophy (HP:0001670)4.17615699
28Abnormal respiratory motile cilium physiology (HP:0012261)4.03765228
29Ventricular fibrillation (HP:0001663)4.01420424
30Atrioventricular block (HP:0001678)3.98965631
31Increased connective tissue (HP:0009025)3.97214562
32Heart block (HP:0012722)3.95855935
33Amelogenesis imperfecta (HP:0000705)3.91920094
34Absent/shortened dynein arms (HP:0200106)3.78857897
35Dynein arm defect of respiratory motile cilia (HP:0012255)3.78857897
36Overgrowth (HP:0001548)3.76305589
37Abnormal atrioventricular conduction (HP:0005150)3.75939093
38Rhinitis (HP:0012384)3.69408934
39Difficulty running (HP:0009046)3.59934572
40Abnormal respiratory motile cilium morphology (HP:0005938)3.50862657
41Abnormal respiratory epithelium morphology (HP:0012253)3.50862657
42Abnormality of calcium-phosphate metabolism (HP:0100530)3.47724302
43Polyuria (HP:0000103)3.44551712
44Rhabdomyolysis (HP:0003201)3.38503690
45Abnormal EKG (HP:0003115)3.36887334
46Abnormal ciliary motility (HP:0012262)3.32078063
47Myotonia (HP:0002486)3.28318757
48Round ear (HP:0100830)3.23548090
49Difficulty climbing stairs (HP:0003551)3.13703050
50Nemaline bodies (HP:0003798)3.10913659
51Abnormality of midbrain morphology (HP:0002418)3.07605728
52Molar tooth sign on MRI (HP:0002419)3.07605728
53Chronic bronchitis (HP:0004469)3.03011154
54Left ventricular hypertrophy (HP:0001712)2.94444151
55Abnormal urine output (HP:0012590)2.87652166
56Osteomalacia (HP:0002749)2.87182586
57Abnormality of renal resorption (HP:0011038)2.83200236
58Ketoacidosis (HP:0001993)2.78739954
59Toxemia of pregnancy (HP:0100603)2.77093901
60Abnormality of the dental pulp (HP:0006479)2.76369525
61Type 1 muscle fiber predominance (HP:0003803)2.73824244
62Abnormality of dental color (HP:0011073)2.66950928
63* Palmoplantar keratoderma (HP:0000982)2.63018198
64Abnormality of renal excretion (HP:0011036)2.59855848
65Nephronophthisis (HP:0000090)2.58503869
66Hypoglycemic coma (HP:0001325)2.53118102
67Increased variability in muscle fiber diameter (HP:0003557)2.43048819
68Testicular atrophy (HP:0000029)2.42591373
69Neck muscle weakness (HP:0000467)2.39816937
70Distal lower limb muscle weakness (HP:0009053)2.38405775
71Ragged-red muscle fibers (HP:0003200)2.36956573
72Hepatic necrosis (HP:0002605)2.36285945
73Mildly elevated creatine phosphokinase (HP:0008180)2.34122109
74Hypoplastic ischia (HP:0003175)2.31334177
75Preauricular pit (HP:0004467)2.28620291
76Periauricular skin pits (HP:0100277)2.28620291
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27208311
78Central scotoma (HP:0000603)2.27124689
79Distal lower limb amyotrophy (HP:0008944)2.27081019
80Areflexia of lower limbs (HP:0002522)2.23361016
81Bronchiectasis (HP:0002110)2.23119795
82* Sudden cardiac death (HP:0001645)2.21530742
83Abnormal mitochondria in muscle tissue (HP:0008316)2.21381511
84Limb-girdle muscle atrophy (HP:0003797)2.20917259
85Abnormality of skeletal muscle fiber size (HP:0012084)2.19502963
86Muscle fiber inclusion bodies (HP:0100299)2.17229584
87Gowers sign (HP:0003391)2.16220717
88Muscle stiffness (HP:0003552)2.14485574
89Volvulus (HP:0002580)2.14190068
90Generalized muscle weakness (HP:0003324)2.11066766
91Acute necrotizing encephalopathy (HP:0006965)2.11053308
92Abnormality of fatty-acid metabolism (HP:0004359)2.10811476
93Dicarboxylic aciduria (HP:0003215)2.09477070
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09477070
95EMG: neuropathic changes (HP:0003445)2.06009453
96Abnormality of the renal medulla (HP:0100957)2.05972310
97Abnormality of the foot musculature (HP:0001436)2.05782087
98Congestive heart failure (HP:0001635)2.04943189
99Scapular winging (HP:0003691)2.04093706
100Muscular dystrophy (HP:0003560)2.02849038
101Conjunctival hamartoma (HP:0100780)2.01905265
102Abnormality of the ischium (HP:0003174)2.00532829
103Dysmetric saccades (HP:0000641)1.94595793
104Hepatocellular necrosis (HP:0001404)1.92509899
105Pancreatic fibrosis (HP:0100732)1.92439983
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.91253579
107Broad metatarsal (HP:0001783)1.91211967
108Hyperinsulinemic hypoglycemia (HP:0000825)1.91152303
109Large for gestational age (HP:0001520)1.88085910
110Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87521209
111Hamartoma of the eye (HP:0010568)1.86796716
112Skin pits (HP:0100276)1.86432477
113Ketosis (HP:0001946)1.85540764
114Rimmed vacuoles (HP:0003805)1.84559310
115Increased muscle lipid content (HP:0009058)1.84322030
116Foot dorsiflexor weakness (HP:0009027)1.84307327
117Lower limb amyotrophy (HP:0007210)1.82623747
118Congenital malformation of the right heart (HP:0011723)1.81365890
119Double outlet right ventricle (HP:0001719)1.81365890
120Lymphangioma (HP:0100764)1.79941318
121Cerebral edema (HP:0002181)1.79876973
122Acute encephalopathy (HP:0006846)1.79566273
123Depressed nasal tip (HP:0000437)1.78771997
124Tachypnea (HP:0002789)1.75685262
125Frequent falls (HP:0002359)1.75197541
126Pheochromocytoma (HP:0002666)1.74225025
127Hip contracture (HP:0003273)1.74090674
128Neoplasm of the adrenal gland (HP:0100631)1.72598847
129Lip pit (HP:0100267)1.72528121
130Progressive macrocephaly (HP:0004481)1.70782216
131Pancreatic cysts (HP:0001737)1.70397153
132Hypoplastic left heart (HP:0004383)1.69688529
133Abnormality of urine glucose concentration (HP:0011016)1.69236064
134Glycosuria (HP:0003076)1.69236064
135Mitochondrial inheritance (HP:0001427)1.69022315
136Aplasia of the musculature (HP:0100854)1.67652993
137Exercise intolerance (HP:0003546)1.67472011
138Abnormality of alanine metabolism (HP:0010916)1.67345648
139Hyperalaninemia (HP:0003348)1.67345648
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67345648
141True hermaphroditism (HP:0010459)1.66690576
142Hypoplastic heart (HP:0001961)1.61166004
143Distal arthrogryposis (HP:0005684)1.54986202
144Type 2 muscle fiber atrophy (HP:0003554)1.54611782
145Decreased circulating renin level (HP:0003351)1.54513417
146Hyperkalemia (HP:0002153)1.53067337
147Abnormality of the renal cortex (HP:0011035)1.52736255
148Drooling (HP:0002307)1.51627915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK27.32104868
2TTN5.29571527
3OBSCN4.83726196
4LMTK23.80951847
5PHKG13.80327590
6PHKG23.80327590
7MYLK3.50489969
8PKN23.41416699
9DMPK3.35412311
10PDK33.19504958
11PDK43.19504958
12TRIB32.91378380
13MUSK2.68652198
14FRK2.41731315
15BLK2.41483722
16NEK12.24673104
17PIK3CA2.23817273
18STK242.19400156
19BCKDK1.96732360
20TIE11.94497252
21PDK21.86467545
22PINK11.80499795
23MAP4K11.78464018
24MAPK151.77261080
25PAK31.51921446
26CAMK2D1.37573608
27ILK1.36335961
28PRKD11.31825522
29INSRR1.31149442
30ZAK1.29736415
31GRK71.27606606
32MARK11.23787632
33CDC42BPA1.18761321
34ADRBK21.17622206
35WNK41.16139204
36MAP3K71.08689857
37ROCK11.04504714
38EPHB11.02616695
39TRPM70.98056691
40STK38L0.97415770
41STK40.97349982
42PRKAA10.96447304
43PRKAA20.96115952
44MAPK120.95523038
45RIPK10.92871652
46GRK10.91121036
47MAP3K50.87355583
48BMPR1B0.86202799
49EPHA30.85010635
50PDGFRA0.83529891
51FLT30.80459376
52MAP4K20.79501891
53MAPKAPK30.78417548
54CAMK40.77461059
55STK380.74922496
56WNK30.74110231
57PKN10.70061564
58WNK10.66763673
59DAPK30.65808654
60EEF2K0.61869965
61CAMK2A0.60969784
62LATS10.60581078
63PTK2B0.59559223
64ROCK20.57497145
65SIK10.56039042
66FGFR40.55975752
67TXK0.53245724
68ICK0.52667420
69ITK0.51858647
70CAMK10.51841907
71MAP2K30.50938896
72KDR0.49708941
73RPS6KL10.49546666
74RPS6KC10.49546666
75PRKACB0.48827136
76PTK60.47909900
77PRKCE0.47414168
78TAOK30.45324794
79MAP3K30.44980912
80ADRBK10.43412384
81TGFBR20.43197497
82FER0.43164750
83AKT20.42459174
84MAPK130.41806919
85PRKACG0.41521211
86PRKCQ0.40071601
87TNIK0.39392290
88RPS6KA60.38605347
89NEK90.38258963
90MAP3K40.38108038
91CCNB10.37940010
92PRKACA0.37878395
93PLK40.37657213
94MTOR0.37400720
95PRKG20.35735471
96MAP2K10.35089517
97CAMK2B0.35002058
98RET0.34120036
99PRKCI0.33600291
100PAK60.32390211
101NTRK30.32310976
102PRKCA0.31816466
103HIPK20.31758336
104SYK0.31380238
105MAP3K100.30773831
106MAP2K60.30309553
107JAK10.29338283
108STK390.28218624
109LATS20.28136907
110EPHB20.27089369
111MAP2K40.26044912
112RPS6KA10.25930984
113PDPK10.25199384
114TLK10.25003670
115MAPK40.24893998
116CAMK2G0.23620232
117TEC0.23570935
118PIK3CG0.23275196
119PRKDC0.22778897
120CAMK1D0.22641066
121SGK30.22627240
122FGFR10.22452393
123KIT0.22342384
124SRC0.22208790
125PRKG10.21783765
126OXSR10.21321095
127PDK10.20833355
128ERBB30.20723327
129PRKCH0.20441425
130GSK3B0.19698781
131AKT10.19431224
132FGFR30.18777022
133STK30.18674285
134RPS6KA30.18205960
135MAPK70.17811397
136PDGFRB0.16792638
137SGK10.16178820
138MAP3K10.14282304
139CAMK1G0.14173539
140KSR20.13616668

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.61489494
2Cardiac muscle contraction_Homo sapiens_hsa042604.31114617
3Dilated cardiomyopathy_Homo sapiens_hsa054144.23934636
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.16530226
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.14876810
6Olfactory transduction_Homo sapiens_hsa047403.61910810
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16424747
8Propanoate metabolism_Homo sapiens_hsa006402.98569049
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.95581999
10Fatty acid degradation_Homo sapiens_hsa000712.77667396
11Linoleic acid metabolism_Homo sapiens_hsa005912.77122661
12Sulfur metabolism_Homo sapiens_hsa009202.50544128
13Parkinsons disease_Homo sapiens_hsa050122.49048339
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34751490
15Oxidative phosphorylation_Homo sapiens_hsa001902.33281017
16Carbon metabolism_Homo sapiens_hsa012002.32790821
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13297705
18Fatty acid metabolism_Homo sapiens_hsa012122.08478949
19Sulfur relay system_Homo sapiens_hsa041222.04470871
20Viral myocarditis_Homo sapiens_hsa054162.03039506
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.95128913
22Alzheimers disease_Homo sapiens_hsa050101.85063058
23Pyruvate metabolism_Homo sapiens_hsa006201.72052483
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70182236
25Salivary secretion_Homo sapiens_hsa049701.68865364
26Morphine addiction_Homo sapiens_hsa050321.55983260
27Huntingtons disease_Homo sapiens_hsa050161.54235122
28GABAergic synapse_Homo sapiens_hsa047271.47276093
29Butanoate metabolism_Homo sapiens_hsa006501.36475940
30Ether lipid metabolism_Homo sapiens_hsa005651.30409959
31Thyroid hormone synthesis_Homo sapiens_hsa049181.29343388
32Fat digestion and absorption_Homo sapiens_hsa049751.29131031
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26176226
34Glutamatergic synapse_Homo sapiens_hsa047241.26052401
35Starch and sucrose metabolism_Homo sapiens_hsa005001.21737706
36Cocaine addiction_Homo sapiens_hsa050301.21289499
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19312156
38Amphetamine addiction_Homo sapiens_hsa050311.18336633
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18298387
40Insulin resistance_Homo sapiens_hsa049311.18084122
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16493045
42Glucagon signaling pathway_Homo sapiens_hsa049221.13753101
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.09413410
44Biosynthesis of amino acids_Homo sapiens_hsa012301.07361554
45Fatty acid elongation_Homo sapiens_hsa000621.07157106
46PPAR signaling pathway_Homo sapiens_hsa033201.03279274
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02766502
48Lysine degradation_Homo sapiens_hsa003100.99910130
49Insulin signaling pathway_Homo sapiens_hsa049100.99277726
50Arachidonic acid metabolism_Homo sapiens_hsa005900.93925066
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93245162
52Focal adhesion_Homo sapiens_hsa045100.90742080
53Collecting duct acid secretion_Homo sapiens_hsa049660.88383380
54beta-Alanine metabolism_Homo sapiens_hsa004100.87980160
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86765784
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84790813
57Type II diabetes mellitus_Homo sapiens_hsa049300.84046768
58Serotonergic synapse_Homo sapiens_hsa047260.81804239
59Tryptophan metabolism_Homo sapiens_hsa003800.81461191
60AMPK signaling pathway_Homo sapiens_hsa041520.79537948
61Arginine biosynthesis_Homo sapiens_hsa002200.79200233
62Phototransduction_Homo sapiens_hsa047440.76099678
63Melanogenesis_Homo sapiens_hsa049160.75581816
64Calcium signaling pathway_Homo sapiens_hsa040200.74515003
65Oxytocin signaling pathway_Homo sapiens_hsa049210.74107567
66HIF-1 signaling pathway_Homo sapiens_hsa040660.73845562
67Arginine and proline metabolism_Homo sapiens_hsa003300.73526175
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70439991
69Tight junction_Homo sapiens_hsa045300.69806723
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.68057381
71Adherens junction_Homo sapiens_hsa045200.65098831
72ECM-receptor interaction_Homo sapiens_hsa045120.63854474
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62751471
74Fatty acid biosynthesis_Homo sapiens_hsa000610.61390612
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59804351
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.58314361
77ABC transporters_Homo sapiens_hsa020100.55777111
78Caffeine metabolism_Homo sapiens_hsa002320.55427603
79RNA degradation_Homo sapiens_hsa030180.54711537
80Nitrogen metabolism_Homo sapiens_hsa009100.53532350
81Insulin secretion_Homo sapiens_hsa049110.52144269
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51855031
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51605988
84Fructose and mannose metabolism_Homo sapiens_hsa000510.51328262
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50967537
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49560845
87cAMP signaling pathway_Homo sapiens_hsa040240.49153922
88Galactose metabolism_Homo sapiens_hsa000520.48576817
89Phenylalanine metabolism_Homo sapiens_hsa003600.47883254
90Renin secretion_Homo sapiens_hsa049240.47472877
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46662091
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45290050
93Circadian rhythm_Homo sapiens_hsa047100.45204251
94Ovarian steroidogenesis_Homo sapiens_hsa049130.44773090
95Synaptic vesicle cycle_Homo sapiens_hsa047210.44018993
96Histidine metabolism_Homo sapiens_hsa003400.41061092
97Dorso-ventral axis formation_Homo sapiens_hsa043200.40905197
98Chemical carcinogenesis_Homo sapiens_hsa052040.40346122
99Dopaminergic synapse_Homo sapiens_hsa047280.39882037
100Oocyte meiosis_Homo sapiens_hsa041140.38140714
101Gastric acid secretion_Homo sapiens_hsa049710.38003230
102Vibrio cholerae infection_Homo sapiens_hsa051100.37560584
103Purine metabolism_Homo sapiens_hsa002300.36899910
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.36622036
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36317390
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35944746
107Nicotine addiction_Homo sapiens_hsa050330.35941732
108Hedgehog signaling pathway_Homo sapiens_hsa043400.35355088
109Amoebiasis_Homo sapiens_hsa051460.35208221
110GnRH signaling pathway_Homo sapiens_hsa049120.34943897
111Peroxisome_Homo sapiens_hsa041460.34595137
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33396356
113Retinol metabolism_Homo sapiens_hsa008300.33177489
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.32581650
115Circadian entrainment_Homo sapiens_hsa047130.32526211
116Proteoglycans in cancer_Homo sapiens_hsa052050.32382007
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31715754
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29756299
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25082698
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24941111
121Renal cell carcinoma_Homo sapiens_hsa052110.23363619
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.23070742
123mTOR signaling pathway_Homo sapiens_hsa041500.22869739
124Platelet activation_Homo sapiens_hsa046110.21532530
125Tyrosine metabolism_Homo sapiens_hsa003500.21388423
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21196414
127VEGF signaling pathway_Homo sapiens_hsa043700.18982974
128Bile secretion_Homo sapiens_hsa049760.17992652
129Small cell lung cancer_Homo sapiens_hsa052220.16864510
130Gap junction_Homo sapiens_hsa045400.14968262
131FoxO signaling pathway_Homo sapiens_hsa040680.14854776
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13003607
133Cholinergic synapse_Homo sapiens_hsa047250.12277252
134Pancreatic secretion_Homo sapiens_hsa049720.12144105
135Metabolic pathways_Homo sapiens_hsa011000.11662395
136Notch signaling pathway_Homo sapiens_hsa043300.09202871
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.09174866
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.08762973
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07535124
140Estrogen signaling pathway_Homo sapiens_hsa049150.06800134
141Rap1 signaling pathway_Homo sapiens_hsa040150.06532092
142Taste transduction_Homo sapiens_hsa047420.06084178
143Toxoplasmosis_Homo sapiens_hsa051450.05155815
144MAPK signaling pathway_Homo sapiens_hsa040100.04448790

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