RBM22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.58274840
2viral transcription (GO:0019083)4.00493108
3translational termination (GO:0006415)3.82782322
4response to peptidoglycan (GO:0032494)3.81722633
5maturation of SSU-rRNA (GO:0030490)3.73125009
6ribosomal small subunit biogenesis (GO:0042274)3.60817377
7DNA unwinding involved in DNA replication (GO:0006268)3.58436741
8negative regulation of erythrocyte differentiation (GO:0045647)3.55882583
9negative regulation of interleukin-12 production (GO:0032695)3.54642548
10protein localization to kinetochore (GO:0034501)3.47909180
11immunoglobulin mediated immune response (GO:0016064)3.43898658
12NIK/NF-kappaB signaling (GO:0038061)3.41627883
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38486838
14DNA strand elongation involved in DNA replication (GO:0006271)3.35584322
15modulation by symbiont of host immune response (GO:0052553)3.33503436
16positive regulation by symbiont of host defense response (GO:0052509)3.33503436
17modulation by symbiont of host defense response (GO:0052031)3.33503436
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33503436
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33503436
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.33503436
21negative regulation of cell killing (GO:0031342)3.31614147
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31614147
23neutrophil activation involved in immune response (GO:0002283)3.30298597
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.30132243
25translational elongation (GO:0006414)3.29924074
26DNA strand elongation (GO:0022616)3.26016776
27telomere maintenance via semi-conservative replication (GO:0032201)3.21221658
28translational initiation (GO:0006413)3.17790214
29mitotic metaphase plate congression (GO:0007080)3.13888770
30telomere maintenance via recombination (GO:0000722)3.12071951
31B cell mediated immunity (GO:0019724)3.11089434
32positive regulation of gamma-delta T cell activation (GO:0046645)3.10567648
33dosage compensation (GO:0007549)3.09148894
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08504995
35DNA replication initiation (GO:0006270)3.04587573
36germinal center formation (GO:0002467)3.01533733
37cotranslational protein targeting to membrane (GO:0006613)3.01409681
38regulation of B cell receptor signaling pathway (GO:0050855)3.00843991
39mitotic recombination (GO:0006312)3.00692690
40protein localization to chromosome, centromeric region (GO:0071459)2.99874623
41kinetochore organization (GO:0051383)2.99758722
42protein targeting to ER (GO:0045047)2.99734112
43viral life cycle (GO:0019058)2.99163262
44cellular protein complex disassembly (GO:0043624)2.98898354
45negative regulation of RNA splicing (GO:0033119)2.96201224
46mitotic nuclear envelope disassembly (GO:0007077)2.94752469
47ribosome assembly (GO:0042255)2.90082286
48metaphase plate congression (GO:0051310)2.88819112
49nuclear pore organization (GO:0006999)2.88237543
50positive regulation of granulocyte differentiation (GO:0030854)2.86152600
51mitotic chromosome condensation (GO:0007076)2.86023077
52nuclear-transcribed mRNA catabolic process (GO:0000956)2.85471145
53establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85074623
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84899695
55regulation of sister chromatid cohesion (GO:0007063)2.84884584
56formation of translation preinitiation complex (GO:0001731)2.84338039
57cellular response to type I interferon (GO:0071357)2.83452230
58type I interferon signaling pathway (GO:0060337)2.83452230
59nuclear pore complex assembly (GO:0051292)2.83328005
60protein complex disassembly (GO:0043241)2.79932496
61lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79863292
62ribosomal large subunit biogenesis (GO:0042273)2.79221015
63DNA topological change (GO:0006265)2.79162637
64mature B cell differentiation involved in immune response (GO:0002313)2.77141446
65defense response to protozoan (GO:0042832)2.76103447
66response to type I interferon (GO:0034340)2.75618534
67mRNA catabolic process (GO:0006402)2.74968027
68protein localization to endoplasmic reticulum (GO:0070972)2.74855923
69response to protozoan (GO:0001562)2.72370979
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72150682
71* RNA splicing, via transesterification reactions (GO:0000375)2.72043328
72establishment of chromosome localization (GO:0051303)2.71589116
73positive regulation of chromosome segregation (GO:0051984)2.71513583
74* mRNA splicing, via spliceosome (GO:0000398)2.71094386
75* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71094386
76nuclear envelope disassembly (GO:0051081)2.70997445
77membrane disassembly (GO:0030397)2.70997445
78RNA catabolic process (GO:0006401)2.70773051
79positive regulation of B cell differentiation (GO:0045579)2.69623477
80granulocyte activation (GO:0036230)2.69106243
81ribonucleoprotein complex biogenesis (GO:0022613)2.67471397
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.67142089
83neutrophil activation (GO:0042119)2.65386308
84tolerance induction (GO:0002507)2.64963953
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64801644
86response to muramyl dipeptide (GO:0032495)2.64543727
87regulation of interferon-beta biosynthetic process (GO:0045357)2.63609954
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63262433
89viral mRNA export from host cell nucleus (GO:0046784)2.63161654
90leukocyte aggregation (GO:0070486)2.63087567
91DNA replication checkpoint (GO:0000076)2.58954064
92macromolecular complex disassembly (GO:0032984)2.58629810
93regulation of vitamin D biosynthetic process (GO:0060556)2.57980637
94negative regulation of T cell mediated immunity (GO:0002710)2.57448767
95telomere maintenance via telomere lengthening (GO:0010833)2.56833527
96sister chromatid segregation (GO:0000819)2.56677393
97mitotic sister chromatid segregation (GO:0000070)2.56334129
98V(D)J recombination (GO:0033151)2.56317453
99myeloid dendritic cell activation (GO:0001773)2.55507816
100kinetochore assembly (GO:0051382)2.54521529
101regulation of gamma-delta T cell activation (GO:0046643)2.54049800
102negative regulation of mRNA processing (GO:0050686)2.53735241
103termination of RNA polymerase II transcription (GO:0006369)2.53381058
104rRNA processing (GO:0006364)2.52502910
105negative T cell selection (GO:0043383)2.51966439
106attachment of spindle microtubules to kinetochore (GO:0008608)2.51061381
107pore complex assembly (GO:0046931)2.50780812
108regulation of chronic inflammatory response (GO:0002676)2.50713464
1093-UTR-mediated mRNA stabilization (GO:0070935)2.50524405
110regulation of interferon-alpha production (GO:0032647)2.49909683
111positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.49719069
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49410294
113antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49410294
114regulation of spindle organization (GO:0090224)2.49269619
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48334461
116negative thymic T cell selection (GO:0045060)2.47870811
117rRNA metabolic process (GO:0016072)2.45371027
118response to host immune response (GO:0052572)2.45174279
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45174279
120regulation of gamma-delta T cell differentiation (GO:0045586)2.44750487
121IMP biosynthetic process (GO:0006188)2.44305070
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.44095761
123regulation of histone H3-K9 methylation (GO:0051570)2.43889287
124histone H2A monoubiquitination (GO:0035518)2.43813239
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43085413
126regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43081638
127purine nucleotide salvage (GO:0032261)2.42563536
128poly(A)+ mRNA export from nucleus (GO:0016973)2.42437409
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41721124
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.41529903
131positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41529903
132positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41529903
133regulation of T cell tolerance induction (GO:0002664)2.41057393
134antigen processing and presentation of endogenous antigen (GO:0019883)2.40811051
135DNA duplex unwinding (GO:0032508)2.40420811
136neutrophil mediated immunity (GO:0002446)2.39889906
137myeloid dendritic cell differentiation (GO:0043011)2.39877441
138spliceosomal complex assembly (GO:0000245)2.39778112
139telomere organization (GO:0032200)2.38988293
140telomere maintenance (GO:0000723)2.38519945
141CENP-A containing nucleosome assembly (GO:0034080)2.38411887
142DNA geometric change (GO:0032392)2.38238586
143intra-S DNA damage checkpoint (GO:0031573)2.38227397
144DNA replication-independent nucleosome organization (GO:0034724)2.37571042
145DNA replication-independent nucleosome assembly (GO:0006336)2.37571042
146histone mRNA metabolic process (GO:0008334)2.37512990
147detection of other organism (GO:0098543)2.37255665
148B cell receptor signaling pathway (GO:0050853)2.36957070
149regulation of mast cell degranulation (GO:0043304)2.36400175
150folic acid-containing compound biosynthetic process (GO:0009396)2.36206699
151regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.35687368
152macrophage activation involved in immune response (GO:0002281)2.35373500
153negative regulation of cytokine production involved in immune response (GO:0002719)2.35189949
154alternative mRNA splicing, via spliceosome (GO:0000380)2.34790832
155positive regulation of interferon-alpha production (GO:0032727)2.33773802
156negative regulation of histone methylation (GO:0031061)2.33516179
157regulation of T-helper 1 cell differentiation (GO:0045625)2.32595107
158regulation of response to interferon-gamma (GO:0060330)2.32480497
159regulation of B cell differentiation (GO:0045577)2.31645170
160DNA replication-dependent nucleosome assembly (GO:0006335)2.30347388
161DNA replication-dependent nucleosome organization (GO:0034723)2.30347388
162positive thymic T cell selection (GO:0045059)2.30271202
163ribosome biogenesis (GO:0042254)2.30005689
164regulation of B cell apoptotic process (GO:0002902)2.29699937
165negative regulation of lymphocyte mediated immunity (GO:0002707)2.29414444
166nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.28204145
167detection of bacterium (GO:0016045)2.28133828
168regulation of interleukin-2 biosynthetic process (GO:0045076)2.27861278
169nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.27717808
170positive regulation of interferon-beta production (GO:0032728)2.27565054
171regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26639217
172interferon-gamma-mediated signaling pathway (GO:0060333)2.26569213
173T cell migration (GO:0072678)2.25454047
174cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.22913732
175positive regulation of interleukin-2 production (GO:0032743)2.22325588
176response to host (GO:0075136)2.22134337
177response to host defenses (GO:0052200)2.22134337
178response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.22134337
179myeloid cell activation involved in immune response (GO:0002275)2.22026775
180regulation of podosome assembly (GO:0071801)2.21685732
181regulation of isotype switching (GO:0045191)2.20705621
182spliceosomal tri-snRNP complex assembly (GO:0000244)2.20704320
183regulation of mast cell activation involved in immune response (GO:0033006)2.20447917
184regulation of granulocyte differentiation (GO:0030852)2.18397565
185positive regulation of interleukin-10 production (GO:0032733)2.18322317
186positive regulation of isotype switching (GO:0045830)2.17320630
187T-helper 1 type immune response (GO:0042088)2.14414755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.54853156
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.30957310
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57401417
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.19355414
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03864979
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.98784284
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95951544
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90026613
9MYC_22102868_ChIP-Seq_BL_Human2.88740309
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44259644
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.30745044
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.22821599
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18259805
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15197581
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15194037
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15047972
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12216261
18XRN2_22483619_ChIP-Seq_HELA_Human2.10018813
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.07955394
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.05647081
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02795121
22* VDR_23849224_ChIP-Seq_CD4+_Human2.01054816
23* ETS1_20019798_ChIP-Seq_JURKAT_Human1.95865488
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93358377
25VDR_21846776_ChIP-Seq_THP-1_Human1.92377163
26CIITA_25753668_ChIP-Seq_RAJI_Human1.92203952
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.92161620
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91829559
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88685288
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86056968
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85246555
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84862960
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79403982
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76231825
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.75466169
36* ELK1_19687146_ChIP-ChIP_HELA_Human1.74448281
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73739235
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72571493
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71106753
40SCL_19346495_ChIP-Seq_HPC-7_Human1.70969671
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67543249
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67442587
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.66497334
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64816907
45* SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62874104
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.62479097
47* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60091626
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58646777
49TTF2_22483619_ChIP-Seq_HELA_Human1.58289941
50SPI1_23547873_ChIP-Seq_NB4_Human1.56375717
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56141102
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55718491
53MAF_26560356_Chip-Seq_TH1_Human1.54091962
54MYB_26560356_Chip-Seq_TH2_Human1.52307584
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48692023
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48348589
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47010765
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46866792
59MYB_26560356_Chip-Seq_TH1_Human1.46062135
60UTX_26944678_Chip-Seq_JUKART_Human1.44573284
61DCP1A_22483619_ChIP-Seq_HELA_Human1.43632549
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43290753
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41606298
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41520070
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40385690
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38652638
67* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36846278
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36843649
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34685091
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34558556
71GABP_19822575_ChIP-Seq_HepG2_Human1.33793975
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.33360026
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.33041246
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31802522
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31192045
76* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31159555
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30876497
78KDM5A_27292631_Chip-Seq_BREAST_Human1.30768636
79AR_21909140_ChIP-Seq_LNCAP_Human1.30089789
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29847530
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28253234
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27232511
83* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25279979
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.23523039
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22956222
86TCF7_22412390_ChIP-Seq_EML_Mouse1.20197517
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18004572
88VDR_24763502_ChIP-Seq_THP-1_Human1.15984087
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.15552318
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13674393
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12209603
92MAF_26560356_Chip-Seq_TH2_Human1.12121488
93* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10072574
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10063579
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08197519
96TFEB_21752829_ChIP-Seq_HELA_Human1.05761948
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05585716
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03460234
99* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02781611
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02395414
101YY1_21170310_ChIP-Seq_MESCs_Mouse0.99391981
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99060980
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98503822
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97325530
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97203227
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93266413
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92790075
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92228630
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92199013
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.91200991
111BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89910333
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89468088
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88371349
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87912106
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87242867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.19711681
2MP0008057_abnormal_DNA_replication3.01241830
3MP0003077_abnormal_cell_cycle2.94759338
4MP0003693_abnormal_embryo_hatching2.90090897
5MP0002396_abnormal_hematopoietic_system2.89490794
6MP0004957_abnormal_blastocyst_morpholog2.83074603
7MP0003763_abnormal_thymus_physiology2.78870876
8MP0003111_abnormal_nucleus_morphology2.75861900
9MP0008007_abnormal_cellular_replicative2.28860892
10MP0001835_abnormal_antigen_presentation2.22475961
11MP0003656_abnormal_erythrocyte_physiolo2.19848070
12MP0004808_abnormal_hematopoietic_stem2.19789617
13MP0000685_abnormal_immune_system2.17284859
14MP0003300_gastrointestinal_ulcer2.16652513
15MP0003806_abnormal_nucleotide_metabolis2.11005488
16MP0009333_abnormal_splenocyte_physiolog2.10585194
17MP0005671_abnormal_response_to2.09413194
18MP0002398_abnormal_bone_marrow2.06623781
19MP0008058_abnormal_DNA_repair2.05295211
20MP0001800_abnormal_humoral_immune1.98617175
21MP0010352_gastrointestinal_tract_polyps1.91127517
22MP0000703_abnormal_thymus_morphology1.85929532
23MP0002420_abnormal_adaptive_immunity1.74474678
24MP0002452_abnormal_antigen_presenting1.73602075
25MP0000350_abnormal_cell_proliferation1.72987453
26MP0005058_abnormal_lysosome_morphology1.72367141
27MP0001819_abnormal_immune_cell1.71582539
28MP0005076_abnormal_cell_differentiation1.71575707
29MP0002722_abnormal_immune_system1.65413086
30MP0000716_abnormal_immune_system1.64217993
31MP0005000_abnormal_immune_tolerance1.63808160
32MP0002723_abnormal_immune_serum1.62713776
33MP0000490_abnormal_crypts_of1.62627177
34MP0005387_immune_system_phenotype1.62306729
35MP0001790_abnormal_immune_system1.62306729
36MP0000689_abnormal_spleen_morphology1.61486955
37MP0008260_abnormal_autophagy1.60940891
38MP0009278_abnormal_bone_marrow1.59556500
39MP0008932_abnormal_embryonic_tissue1.55649980
40MP0010030_abnormal_orbit_morphology1.54098642
41MP0001730_embryonic_growth_arrest1.53402533
42MP0008961_abnormal_basal_metabolism1.52691498
43MP0002429_abnormal_blood_cell1.50972430
44MP0010307_abnormal_tumor_latency1.50447783
45MP0005397_hematopoietic_system_phenotyp1.45967915
46MP0001545_abnormal_hematopoietic_system1.45967915
47MP0002019_abnormal_tumor_incidence1.44527965
48MP0002166_altered_tumor_susceptibility1.43407591
49MP0002405_respiratory_system_inflammati1.43392337
50MP0002006_tumorigenesis1.38985834
51MP0003436_decreased_susceptibility_to1.37319772
52MP0009764_decreased_sensitivity_to1.36132155
53MP0008995_early_reproductive_senescence1.34047768
54MP0009785_altered_susceptibility_to1.33796076
55MP0005025_abnormal_response_to1.32363614
56MP0001533_abnormal_skeleton_physiology1.30855449
57MP0000465_gastrointestinal_hemorrhage1.30781603
58MP0003221_abnormal_cardiomyocyte_apopto1.29206584
59MP0005310_abnormal_salivary_gland1.21985101
60MP0002877_abnormal_melanocyte_morpholog1.21641875
61MP0008469_abnormal_protein_level1.21182682
62MP0000858_altered_metastatic_potential1.20905556
63MP0001697_abnormal_embryo_size1.20606700
64MP0000313_abnormal_cell_death1.19905691
65MP0003121_genomic_imprinting1.18891473
66MP0005380_embryogenesis_phenotype1.18353880
67MP0001672_abnormal_embryogenesis/_devel1.18353880
68MP0010155_abnormal_intestine_physiology1.17353099
69MP0003567_abnormal_fetal_cardiomyocyte1.17035980
70MP0003786_premature_aging1.16973558
71MP0003448_altered_tumor_morphology1.15720956
72MP0003303_peritoneal_inflammation1.15360910
73MP0008877_abnormal_DNA_methylation1.15245098
74MP0001873_stomach_inflammation1.11899720
75MP0002148_abnormal_hypersensitivity_rea1.09941663
76MP0009765_abnormal_xenobiotic_induced1.09821815
77MP0003984_embryonic_growth_retardation1.09441003
78MP0003123_paternal_imprinting1.07989539
79MP0002088_abnormal_embryonic_growth/wei1.07176317
80MP0002085_abnormal_embryonic_tissue1.05563780
81MP0002080_prenatal_lethality1.05298174
82MP0002086_abnormal_extraembryonic_tissu1.04609138
83MP0004197_abnormal_fetal_growth/weight/1.03095065
84MP0002419_abnormal_innate_immunity1.01873499
85MP0005451_abnormal_body_composition1.00359956
86MP0001853_heart_inflammation0.99653953
87MP0009763_increased_sensitivity_to0.98820533
88MP0002938_white_spotting0.97233979
89MP0005174_abnormal_tail_pigmentation0.95960162
90MP0005464_abnormal_platelet_physiology0.95197326
91MP0004947_skin_inflammation0.94848007
92MP0006054_spinal_hemorrhage0.93304560
93MP0002332_abnormal_exercise_endurance0.92458820
94MP0002084_abnormal_developmental_patter0.92309625
95MP0002933_joint_inflammation0.91539750
96MP0002277_abnormal_respiratory_mucosa0.90168810
97MP0001727_abnormal_embryo_implantation0.89418173
98MP0003724_increased_susceptibility_to0.87517281
99MP0003866_abnormal_defecation0.87466385
100MP0000733_abnormal_muscle_development0.86245840
101MP0002009_preneoplasia0.86188119
102MP0006082_CNS_inflammation0.85840676
103MP0003172_abnormal_lysosome_physiology0.81790295
104MP0000343_altered_response_to0.81722863
105MP0005023_abnormal_wound_healing0.80602924
106MP0001915_intracranial_hemorrhage0.80189684
107MP0004883_abnormal_blood_vessel0.79709968
108MP0001293_anophthalmia0.78796995
109MP0003075_altered_response_to0.77245974
110MP0005166_decreased_susceptibility_to0.77164094
111MP0006036_abnormal_mitochondrial_physio0.76201286
112MP0008004_abnormal_stomach_pH0.74704169
113MP0003943_abnormal_hepatobiliary_system0.73672832
114MP0002132_abnormal_respiratory_system0.73536506
115MP0005075_abnormal_melanosome_morpholog0.73405973
116MP0003191_abnormal_cellular_cholesterol0.72472422
117MP0001845_abnormal_inflammatory_respons0.71722974
118MP0003787_abnormal_imprinting0.69381746
119MP0005621_abnormal_cell_physiology0.68926949
120MP0003315_abnormal_perineum_morphology0.67881444
121MP0005164_abnormal_response_to0.66802316
122MP0003186_abnormal_redox_activity0.66443647
123MP0003828_pulmonary_edema0.66357690
124MP0002095_abnormal_skin_pigmentation0.66320426
125MP0000477_abnormal_intestine_morphology0.65255973
126MP0001851_eye_inflammation0.64940393
127MP0002925_abnormal_cardiovascular_devel0.63992027
128MP0009840_abnormal_foam_cell0.63014661
129MP0005384_cellular_phenotype0.62583197
130MP0003718_maternal_effect0.62536147
131MP0002932_abnormal_joint_morphology0.62503605
132MP0006292_abnormal_olfactory_placode0.62445632
133MP0003453_abnormal_keratinocyte_physiol0.61796658

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.15870741
2Stomatitis (HP:0010280)4.15593686
3Reticulocytopenia (HP:0001896)3.72863345
4Loss of speech (HP:0002371)3.63022506
5Abnormality of macrophages (HP:0004311)3.55506622
6Birth length less than 3rd percentile (HP:0003561)3.38711727
7Orchitis (HP:0100796)3.13410393
8Optic neuritis (HP:0100653)3.12271312
9Retrobulbar optic neuritis (HP:0100654)3.12271312
10IgM deficiency (HP:0002850)3.01655784
11Abnormality of liposaccharide metabolism (HP:0010968)2.99414775
12Abnormality of glycosphingolipid metabolism (HP:0004343)2.99414775
13Abnormality of glycolipid metabolism (HP:0010969)2.99414775
14Fatigue (HP:0012378)2.94716009
15Increased IgM level (HP:0003496)2.93559809
16T lymphocytopenia (HP:0005403)2.85719767
17Thrombocytosis (HP:0001894)2.84239066
18Cholecystitis (HP:0001082)2.83485835
19Abnormal gallbladder physiology (HP:0012438)2.83485835
20Chromsome breakage (HP:0040012)2.80848594
21Abnormality of T cell number (HP:0011839)2.74367550
22Recurrent viral infections (HP:0004429)2.71965470
23Panhypogammaglobulinemia (HP:0003139)2.70952045
24Abnormality of cells of the erythroid lineage (HP:0012130)2.68766743
25Encephalitis (HP:0002383)2.67821496
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64659999
27Patellar aplasia (HP:0006443)2.62204038
28Urticaria (HP:0001025)2.61010953
29Microvesicular hepatic steatosis (HP:0001414)2.57022851
30Hepatosplenomegaly (HP:0001433)2.56793901
31Autoimmune hemolytic anemia (HP:0001890)2.55842909
32Cutaneous melanoma (HP:0012056)2.50547184
33Abnormality of T cells (HP:0002843)2.49670597
34Keratoconjunctivitis sicca (HP:0001097)2.49026582
35Aplasia/Hypoplasia of the patella (HP:0006498)2.46627134
36Myelodysplasia (HP:0002863)2.45439224
37Lymphoma (HP:0002665)2.45322918
38Chest pain (HP:0100749)2.45123948
39Elevated erythrocyte sedimentation rate (HP:0003565)2.44431034
40Recurrent fungal infections (HP:0002841)2.44288289
41IgG deficiency (HP:0004315)2.43089714
42Syringomyelia (HP:0003396)2.42933095
43Spinal cord lesions (HP:0100561)2.42933095
44Abnormality of the fingertips (HP:0001211)2.42718780
45Abnormal number of erythroid precursors (HP:0012131)2.41802840
46Recurrent bronchitis (HP:0002837)2.41439916
47Aplastic anemia (HP:0001915)2.40308018
48Agammaglobulinemia (HP:0004432)2.38501244
49Gastrointestinal infarctions (HP:0005244)2.38092435
50Vasculitis (HP:0002633)2.37506070
51B lymphocytopenia (HP:0010976)2.37293017
52Abnormality of B cell number (HP:0010975)2.37293017
53Combined immunodeficiency (HP:0005387)2.36408684
54Severe combined immunodeficiency (HP:0004430)2.34699444
55Autoimmune thrombocytopenia (HP:0001973)2.34322464
56Colon cancer (HP:0003003)2.33368244
57Recurrent skin infections (HP:0001581)2.32808690
58Volvulus (HP:0002580)2.31516005
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28901791
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28220033
61Short 4th metacarpal (HP:0010044)2.28220033
62Medulloblastoma (HP:0002885)2.26724536
63Basal cell carcinoma (HP:0002671)2.26378753
64Keratoconjunctivitis (HP:0001096)2.25074772
65Ectopic kidney (HP:0000086)2.25027633
66Vacuolated lymphocytes (HP:0001922)2.24498744
67Increased IgE level (HP:0003212)2.23909292
68Abnormality of the ileum (HP:0001549)2.21671806
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.21154093
70Thyroiditis (HP:0100646)2.19717654
71Breast hypoplasia (HP:0003187)2.17497358
72Meckel diverticulum (HP:0002245)2.17467245
73Abnormality of chromosome stability (HP:0003220)2.16980901
74Progressive external ophthalmoplegia (HP:0000590)2.16515063
75Cellulitis (HP:0100658)2.16261420
76Pallor (HP:0000980)2.15940074
77Osteomyelitis (HP:0002754)2.15436872
78Lymphopenia (HP:0001888)2.14076419
79Acute hepatic failure (HP:0006554)2.13853071
80Viral hepatitis (HP:0006562)2.13112549
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.12797999
82Proximal placement of thumb (HP:0009623)2.10704018
83Pulmonary infiltrates (HP:0002113)2.09905065
84Gastrointestinal inflammation (HP:0004386)2.08642149
85Deep philtrum (HP:0002002)2.08458812
86Mediastinal lymphadenopathy (HP:0100721)2.08131268
87Inflammation of the large intestine (HP:0002037)2.07693841
88Interstitial pulmonary disease (HP:0006530)2.07315920
89Disinhibition (HP:0000734)2.06607956
90Deviation of the thumb (HP:0009603)2.06156701
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.06039883
92Amaurosis fugax (HP:0100576)2.05981713
93Abnormality of the preputium (HP:0100587)2.05742089
94Ragged-red muscle fibers (HP:0003200)2.03918956
95Chronic otitis media (HP:0000389)2.02001673
96Chronic mucocutaneous candidiasis (HP:0002728)2.01363729
97Recurrent cutaneous fungal infections (HP:0011370)2.01363729
98Anorexia (HP:0002039)2.00990347
99Absent thumb (HP:0009777)2.00212675
100Hypergammaglobulinemia (HP:0010702)1.98462276
101Abnormality of the prostate (HP:0008775)1.97761033
102Hypertensive crisis (HP:0100735)1.97140720
103Agnosia (HP:0010524)1.95903800
104Pustule (HP:0200039)1.95800884
105Abnormality of the pleura (HP:0002103)1.94744373
106Abnormality of T cell physiology (HP:0011840)1.94308870
107Episodic fever (HP:0001954)1.94308779
108Micronodular cirrhosis (HP:0001413)1.94159111
109Myositis (HP:0100614)1.92895126
110Acute lymphatic leukemia (HP:0006721)1.92835113
111Petechiae (HP:0000967)1.92476395
112Meningitis (HP:0001287)1.92291271
113Arterial thrombosis (HP:0004420)1.90050738
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89231295
115Acute myeloid leukemia (HP:0004808)1.89225876
116Bone marrow hypocellularity (HP:0005528)1.89030219
117Eosinophilia (HP:0001880)1.88649866
118Selective tooth agenesis (HP:0001592)1.88480744
119Abnormal number of incisors (HP:0011064)1.88431789
120Abnormality of eosinophils (HP:0001879)1.87341470
121Respiratory difficulties (HP:0002880)1.87253620
122Asymmetry of the thorax (HP:0001555)1.87033267
123Mutism (HP:0002300)1.86600098
124Spontaneous hematomas (HP:0007420)1.86588250
125Trigonocephaly (HP:0000243)1.86537909
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86349904
127Keratitis (HP:0000491)1.85711800
128Colitis (HP:0002583)1.84591418
129Progressive neurologic deterioration (HP:0002344)1.84552547
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.83260994
131Duodenal stenosis (HP:0100867)1.82532999
132Small intestinal stenosis (HP:0012848)1.82532999
133Abnormality of the intervertebral disk (HP:0005108)1.81726817
134Macrocytic anemia (HP:0001972)1.81659791
135Leukocytosis (HP:0001974)1.81414848
136Atresia of the external auditory canal (HP:0000413)1.81389183
137IgA deficiency (HP:0002720)1.80474707
138Constricted visual fields (HP:0001133)1.78981881
139Verrucae (HP:0200043)1.78005784
140Papilloma (HP:0012740)1.78005784
141Premature graying of hair (HP:0002216)1.77583331
142Hemoptysis (HP:0002105)1.76944160
143Glomerulopathy (HP:0100820)1.76281915
144Abnormal lung lobation (HP:0002101)1.76121251
145Long eyelashes (HP:0000527)1.76118197
146Squamous cell carcinoma (HP:0002860)1.74924136
147Abnormality of DNA repair (HP:0003254)1.74705845
148Obstructive lung disease (HP:0006536)1.74682322
149Chronic obstructive pulmonary disease (HP:0006510)1.74682322
150Cutis marmorata (HP:0000965)1.73846574
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.72711563
152Increased nuchal translucency (HP:0010880)1.72598813
153Cellular immunodeficiency (HP:0005374)1.72239555
154Persistence of primary teeth (HP:0006335)1.71669765
15511 pairs of ribs (HP:0000878)1.71532684
156Recurrent abscess formation (HP:0002722)1.71186749
157Degeneration of anterior horn cells (HP:0002398)1.71024826
158Abnormality of the anterior horn cell (HP:0006802)1.71024826
159Clubbing of toes (HP:0100760)1.70511391
160Eczematoid dermatitis (HP:0000976)1.69911627
161Granulocytopenia (HP:0001913)1.69865132
162Short thumb (HP:0009778)1.68589195
163Tracheoesophageal fistula (HP:0002575)1.68032273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.77532056
2MAP4K13.16146205
3CDC72.99771071
4BUB12.61038200
5MKNK12.49334448
6EEF2K2.49164369
7RIPK42.41132584
8MAP3K102.35137940
9TSSK62.33384341
10IRAK32.27014941
11STK102.23808406
12CDK122.21304681
13NME22.19232252
14TXK2.18910858
15PASK2.07831638
16SRPK11.98433114
17CLK11.97880570
18TESK21.74742430
19TRIM281.69839898
20EPHB11.62954775
21MKNK21.59977648
22TGFBR11.58942815
23NEK21.57942262
24WEE11.56174597
25MAP2K31.56138092
26BMPR21.54604839
27RPS6KA41.52722579
28CDK41.47496680
29TLK11.46439336
30MATK1.46120309
31ZAP701.44836854
32VRK11.44617164
33ATR1.40322440
34ERN11.39967604
35PIM11.38994088
36MAP3K31.38834024
37LRRK21.38630630
38RPS6KB21.33769203
39JAK31.33677815
40IRAK11.33405313
41BTK1.30657600
42ACVR1B1.30329090
43CDK71.29510335
44PKN21.28424515
45FES1.28108770
46BRD41.26449234
47SIK31.25488630
48MAP3K141.25474134
49TAOK11.22451653
50EIF2AK11.21257883
51AURKB1.18299817
52SCYL21.13559599
53STK41.13013225
54TYK21.12964586
55MAP3K131.11774136
56PLK11.10758350
57TTK1.08986930
58EIF2AK21.08652284
59IKBKB1.07840458
60CHUK1.05970029
61MAP3K81.04062188
62MST41.03898425
63KIT1.02312666
64GRK61.01061614
65CHEK10.99805286
66DYRK30.99647934
67RAF10.95448244
68TBK10.95426167
69VRK20.95106954
70ERBB30.92571129
71ALK0.91255286
72SYK0.91176250
73CDK60.90945937
74PAK40.90028636
75FGR0.89819396
76MELK0.89526841
77CDK80.89180430
78PLK30.88256232
79BRSK20.87790730
80ITK0.87120874
81TAOK30.87015520
82LCK0.86332267
83BLK0.85014078
84CHEK20.83994276
85MARK30.83178722
86IKBKE0.82612048
87STK30.79985379
88MAP3K10.77192974
89CSF1R0.76692597
90RPS6KA50.72183104
91TEC0.71953280
92KSR20.71672171
93ILK0.70951444
94SMG10.70399014
95JAK20.70201576
96CDK20.70168049
97EPHA30.69867059
98FGFR30.68311377
99PIM20.67644942
100ATM0.66911770
101IRAK40.66768142
102NLK0.65479800
103LYN0.65147870
104BCR0.63775362
105TRIB30.63658579
106KSR10.62251314
107STK160.61977401
108HCK0.60916104
109MAP3K110.56931877
110MOS0.55972899
111CDK90.55640395
112TAOK20.55434379
113EIF2AK30.55284145
114BRSK10.54017847
115CSK0.53595664
116MAPKAPK20.51190088
117CDK10.49756437
118IRAK20.49215180
119KDR0.48369387
120SIK20.46836445
121STK240.46691792
122GRK70.46450966
123HIPK20.44928810
124TGFBR20.42447979
125CCNB10.41821868
126YES10.40590325
127JAK10.40087638
128FGFR40.38975630
129PDK20.38396451
130RPS6KA60.38385732
131MAP3K50.37664714
132MTOR0.37587768
133NEK90.37514999
134NEK10.37383321
135SIK10.37100019
136BMX0.36820409
137NUAK10.36817418
138ARAF0.35813076
139FLT30.35728746
140PRPF4B0.35635916
141RPS6KC10.35058127

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.35229074
2* Spliceosome_Homo sapiens_hsa030402.89803989
3Mismatch repair_Homo sapiens_hsa034302.87495669
4Ribosome_Homo sapiens_hsa030102.84241351
5Base excision repair_Homo sapiens_hsa034102.51040109
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40254568
7Primary immunodeficiency_Homo sapiens_hsa053402.36658702
8Cell cycle_Homo sapiens_hsa041102.23131991
9RNA transport_Homo sapiens_hsa030132.15941124
10Homologous recombination_Homo sapiens_hsa034402.14877867
11RNA polymerase_Homo sapiens_hsa030202.05277449
12Nucleotide excision repair_Homo sapiens_hsa034201.96001766
13Non-homologous end-joining_Homo sapiens_hsa034501.77162836
14Other glycan degradation_Homo sapiens_hsa005111.76587257
15RNA degradation_Homo sapiens_hsa030181.69529868
16mRNA surveillance pathway_Homo sapiens_hsa030151.66184117
17Fanconi anemia pathway_Homo sapiens_hsa034601.65574109
18Antigen processing and presentation_Homo sapiens_hsa046121.58844840
19Herpes simplex infection_Homo sapiens_hsa051681.52362313
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.51123853
21Rheumatoid arthritis_Homo sapiens_hsa053231.49790048
22Type I diabetes mellitus_Homo sapiens_hsa049401.48757371
23Basal transcription factors_Homo sapiens_hsa030221.48741944
24Measles_Homo sapiens_hsa051621.48408902
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47349092
26Proteasome_Homo sapiens_hsa030501.43349452
27T cell receptor signaling pathway_Homo sapiens_hsa046601.36707131
28Pyrimidine metabolism_Homo sapiens_hsa002401.36369297
29p53 signaling pathway_Homo sapiens_hsa041151.34664847
30B cell receptor signaling pathway_Homo sapiens_hsa046621.33885623
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.33295406
32One carbon pool by folate_Homo sapiens_hsa006701.30403230
33Epstein-Barr virus infection_Homo sapiens_hsa051691.28660991
34Leishmaniasis_Homo sapiens_hsa051401.26506672
35HTLV-I infection_Homo sapiens_hsa051661.22882279
36Viral carcinogenesis_Homo sapiens_hsa052031.20646566
37Hematopoietic cell lineage_Homo sapiens_hsa046401.18101253
38Chronic myeloid leukemia_Homo sapiens_hsa052201.13685819
39Acute myeloid leukemia_Homo sapiens_hsa052211.12228292
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12187186
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10853569
42Hepatitis B_Homo sapiens_hsa051611.09911981
43Allograft rejection_Homo sapiens_hsa053301.09639184
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09512122
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08600170
46MicroRNAs in cancer_Homo sapiens_hsa052061.08417683
47Folate biosynthesis_Homo sapiens_hsa007901.06746422
48Notch signaling pathway_Homo sapiens_hsa043301.04561165
49Graft-versus-host disease_Homo sapiens_hsa053321.03478516
50Shigellosis_Homo sapiens_hsa051311.01532680
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99779504
52Pentose phosphate pathway_Homo sapiens_hsa000300.99046727
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98376415
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97318751
55Osteoclast differentiation_Homo sapiens_hsa043800.96977217
56Small cell lung cancer_Homo sapiens_hsa052220.95401281
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95262838
58Colorectal cancer_Homo sapiens_hsa052100.94928742
59Viral myocarditis_Homo sapiens_hsa054160.94342426
60African trypanosomiasis_Homo sapiens_hsa051430.94060094
61Staphylococcus aureus infection_Homo sapiens_hsa051500.93266582
62Apoptosis_Homo sapiens_hsa042100.92988241
63Influenza A_Homo sapiens_hsa051640.92273076
64Legionellosis_Homo sapiens_hsa051340.92041006
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.91825321
66Lysosome_Homo sapiens_hsa041420.91801604
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90108317
68Systemic lupus erythematosus_Homo sapiens_hsa053220.88263701
69Pancreatic cancer_Homo sapiens_hsa052120.82476247
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82446888
71Toxoplasmosis_Homo sapiens_hsa051450.81814902
72Thyroid cancer_Homo sapiens_hsa052160.81517144
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81391719
74Phagosome_Homo sapiens_hsa041450.81151117
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.79971749
76Non-small cell lung cancer_Homo sapiens_hsa052230.79747451
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78041987
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75748420
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73702960
80Asthma_Homo sapiens_hsa053100.72481264
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70056146
82TNF signaling pathway_Homo sapiens_hsa046680.69075621
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66854098
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64925154
85Malaria_Homo sapiens_hsa051440.62408889
86Prostate cancer_Homo sapiens_hsa052150.62226798
87TGF-beta signaling pathway_Homo sapiens_hsa043500.60841696
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.60730569
89Chemokine signaling pathway_Homo sapiens_hsa040620.60441257
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60039980
91Protein export_Homo sapiens_hsa030600.59666113
92Renal cell carcinoma_Homo sapiens_hsa052110.59508662
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59478962
94Pathways in cancer_Homo sapiens_hsa052000.58851183
95Purine metabolism_Homo sapiens_hsa002300.58646625
96Sulfur relay system_Homo sapiens_hsa041220.58461420
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57436847
98Autoimmune thyroid disease_Homo sapiens_hsa053200.57231368
99Prion diseases_Homo sapiens_hsa050200.56930702
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.56406810
101Endometrial cancer_Homo sapiens_hsa052130.55791008
102Basal cell carcinoma_Homo sapiens_hsa052170.54779437
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54129818
104Platelet activation_Homo sapiens_hsa046110.52298845
105Proteoglycans in cancer_Homo sapiens_hsa052050.52146057
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51795489
107FoxO signaling pathway_Homo sapiens_hsa040680.51321430
108Pertussis_Homo sapiens_hsa051330.50259570
109Oocyte meiosis_Homo sapiens_hsa041140.48857321
110Tuberculosis_Homo sapiens_hsa051520.47478261
111Collecting duct acid secretion_Homo sapiens_hsa049660.46830803
112Hippo signaling pathway_Homo sapiens_hsa043900.46530199
113Salmonella infection_Homo sapiens_hsa051320.46263095
114Prolactin signaling pathway_Homo sapiens_hsa049170.46218661
115Hepatitis C_Homo sapiens_hsa051600.45500559
116Steroid biosynthesis_Homo sapiens_hsa001000.45401240
117Vibrio cholerae infection_Homo sapiens_hsa051100.45392187
118HIF-1 signaling pathway_Homo sapiens_hsa040660.45345787
119VEGF signaling pathway_Homo sapiens_hsa043700.44638391
120Regulation of autophagy_Homo sapiens_hsa041400.44613139
121Endocytosis_Homo sapiens_hsa041440.43897555
122mTOR signaling pathway_Homo sapiens_hsa041500.43022791
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.41088767
124Bladder cancer_Homo sapiens_hsa052190.40127904

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