ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	inositol phosphate dephosphorylation (GO:0046855)	9.13745895
2	phosphorylated carbohydrate dephosphorylation (GO:0046838)	9.13745895
3	cullin deneddylation (GO:0010388)	8.97336114
4	inositol phosphate catabolic process (GO:0071545)	8.26476898
5	protein deneddylation (GO:0000338)	8.20995450
6	platelet dense granule organization (GO:0060155)	7.96352828
7	regulation of vesicle fusion (GO:0031338)	6.83881743
8	vitamin transmembrane transport (GO:0035461)	6.81769834
9	inositol metabolic process (GO:0006020)	6.66198599
10	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	6.62344829
11	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	6.52163578
12	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	6.52163578
13	response to misfolded protein (GO:0051788)	6.47691733
14	proline transport (GO:0015824)	6.47505060
15	protein targeting to Golgi (GO:0000042)	5.86144198
16	establishment of protein localization to Golgi (GO:0072600)	5.74263767
17	regulation of Rac protein signal transduction (GO:0035020)	5.58775718
18	polyol catabolic process (GO:0046174)	5.57428437
19	early endosome to late endosome transport (GO:0045022)	5.46806002
20	L-ascorbic acid metabolic process (GO:0019852)	5.43678851
21	regulation of sequestering of triglyceride (GO:0010889)	5.36633118
22	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.26420340
23	transepithelial transport (GO:0070633)	5.23040842
24	righting reflex (GO:0060013)	5.20142941
25	rhodopsin mediated signaling pathway (GO:0016056)	5.16355832
26	negative regulation of exocytosis (GO:0045920)	5.14786274
27	positive regulation of action potential (GO:0045760)	5.04015282
28	artery development (GO:0060840)	5.01577793
29	receptor recycling (GO:0001881)	4.97964062
30	endosome organization (GO:0007032)	4.91039526
31	protein localization to Golgi apparatus (GO:0034067)	4.78567102
32	photoreceptor cell maintenance (GO:0045494)	4.73709721
33	histone H2A ubiquitination (GO:0033522)	4.62126806
34	alanine transport (GO:0032328)	4.59654834
35	ADP metabolic process (GO:0046031)	4.59610186
36	DNA replication-dependent nucleosome assembly (GO:0006335)	4.55438146
37	DNA replication-dependent nucleosome organization (GO:0034723)	4.55438146
38	phosphatidylinositol phosphorylation (GO:0046854)	4.53078564
39	positive regulation of mitochondrial membrane permeability (GO:0035794)	4.43226917
40	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	4.42359334
41	retinol metabolic process (GO:0042572)	4.42206936
42	microtubule nucleation (GO:0007020)	4.39347965
43	auditory behavior (GO:0031223)	4.35324108
44	reflex (GO:0060004)	3.86079375
45	anterograde synaptic vesicle transport (GO:0048490)	3.82164310
46	behavioral response to nicotine (GO:0035095)	3.71996897
47	behavioral response to ethanol (GO:0048149)	3.68812992
48	lipid phosphorylation (GO:0046834)	3.68184737
49	protein polyglutamylation (GO:0018095)	3.57436149
50	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.56420099
51	regulation of action potential (GO:0098900)	3.53976943
52	regulation of mitotic spindle checkpoint (GO:1903504)	3.37916151
53	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.37916151
54	postreplication repair (GO:0006301)	3.37117375
55	regulation of prostaglandin secretion (GO:0032306)	3.33358227
56	polyol biosynthetic process (GO:0046173)	3.32494890
57	thyroid gland development (GO:0030878)	3.28438138
58	intra-Golgi vesicle-mediated transport (GO:0006891)	3.25737499
59	wound healing, spreading of epidermal cells (GO:0035313)	3.22288329
60	secretory granule organization (GO:0033363)	3.21650535
61	protein-cofactor linkage (GO:0018065)	3.21555375
62	positive regulation of cAMP-mediated signaling (GO:0043950)	3.19585121
63	positive regulation of tolerance induction (GO:0002645)	3.17451221
64	negative regulation of protein autophosphorylation (GO:0031953)	3.15302751
65	neuronal action potential (GO:0019228)	3.14012069
66	primary amino compound metabolic process (GO:1901160)	3.12893832
67	serotonin metabolic process (GO:0042428)	3.12407183
68	mechanosensory behavior (GO:0007638)	3.11052274
69	microtubule depolymerization (GO:0007019)	3.08190953
70	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.07827052
71	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.07827052
72	regulation of gamma-delta T cell differentiation (GO:0045586)	3.07173012
73	folic acid-containing compound biosynthetic process (GO:0009396)	3.05103517
74	protein K11-linked ubiquitination (GO:0070979)	2.94194688
75	melanosome organization (GO:0032438)	2.90936531
76	inner ear receptor stereocilium organization (GO:0060122)	2.89951940
77	phototransduction (GO:0007602)	2.89221644
78	lymphangiogenesis (GO:0001946)	2.85809054
79	protein K11-linked deubiquitination (GO:0035871)	2.83573289
80	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	2.82156547
81	regulation of MHC class I biosynthetic process (GO:0045343)	2.82123192
82	detection of light stimulus (GO:0009583)	2.80345786
83	primary alcohol metabolic process (GO:0034308)	2.77496315
84	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.77467847
85	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.77467847
86	axoneme assembly (GO:0035082)	2.76623426
87	pigment granule organization (GO:0048753)	2.75312392
88	regulation of T cell tolerance induction (GO:0002664)	2.72832606
89	anterograde axon cargo transport (GO:0008089)	2.69896765
90	positive regulation of lipid storage (GO:0010884)	2.68353897
91	positive regulation of cell cycle G1/S phase transition (GO:1902808)	2.59629020
92	transcytosis (GO:0045056)	2.58134521
93	UTP metabolic process (GO:0046051)	2.57961029
94	regulation of gamma-delta T cell activation (GO:0046643)	2.57697664
95	fusion of sperm to egg plasma membrane (GO:0007342)	2.57235021
96	sequestering of extracellular ligand from receptor (GO:0035581)	2.54589071
97	kynurenine metabolic process (GO:0070189)	2.53584937
98	indolalkylamine catabolic process (GO:0046218)	2.52944483
99	tryptophan catabolic process (GO:0006569)	2.52944483
100	protein-chromophore linkage (GO:0018298)	11.1418871

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.57751067
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.08491703
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.74881567
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.70729340
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.26342270
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.26219916
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.86438167
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.61711205
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.52238893
10	FUS_26573619_Chip-Seq_HEK293_Human	2.40227244
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17890738
12	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.16854064
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16324421
14	P300_19829295_ChIP-Seq_ESCs_Human	2.04244754
15	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.03368147
16	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.02259299
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.90100349
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.89421590
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87644547
20	SOX2_19829295_ChIP-Seq_ESCs_Human	1.87428182
21	NANOG_19829295_ChIP-Seq_ESCs_Human	1.87428182
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86889394
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83914190
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74702235
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73605379
26	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.70008421
27	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.67386141
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64714463
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56650208
30	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.55913982
31	STAT3_23295773_ChIP-Seq_U87_Human	1.55564098
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48208184
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44423728
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43591962
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41029911
36	EWS_26573619_Chip-Seq_HEK293_Human	1.39670688
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39103866
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38615461
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38615461
40	TCF4_23295773_ChIP-Seq_U87_Human	1.38026432
41	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.37832248
42	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.35007154
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34939126
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32196705
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31599692
46	AR_25329375_ChIP-Seq_VCAP_Human	1.31475307
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29733060
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29733060
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29203164
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28803960
51	JUN_21703547_ChIP-Seq_K562_Human	1.26608074
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26557176
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26295353
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.26290763
55	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24373102
56	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23826071
57	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23199557
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22967300
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22324451
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21824513
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21139536
62	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.21103277
63	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20861518
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19195729
65	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.18943956
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18671837
67	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.17053923
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16309026
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14850477
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12860815
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12180149
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11665439
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11544072
74	AR_19668381_ChIP-Seq_PC3_Human	1.10526550
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.09567944
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09421335
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.09352009
78	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.09182171
79	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09097381
80	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08524568
81	KDM2B_26808549_Chip-Seq_REH_Human	1.08091281
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07915774
83	AHR_22903824_ChIP-Seq_MCF-7_Human	1.07132955
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07107030
85	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05262454
86	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05242523
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05224789
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04804488
89	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04795602
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04684810
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04499168
92	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.03997779
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02656361
94	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.00940498
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00457087
96	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.00188429
97	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99453889
98	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.99046581
99	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.97876645
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97791780

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	9.57539756
2	MP0005083_abnormal_biliary_tract	9.27575694
3	MP0002638_abnormal_pupillary_reflex	6.69490012
4	MP0005085_abnormal_gallbladder_physiolo	5.37364861
5	MP0005084_abnormal_gallbladder_morpholo	5.29185279
6	MP0005365_abnormal_bile_salt	4.56784848
7	MP0002928_abnormal_bile_duct	3.26638800
8	MP0006072_abnormal_retinal_apoptosis	2.83823980
9	MP0005253_abnormal_eye_physiology	2.65764469
10	MP0001764_abnormal_homeostasis	2.52127825
11	MP0005379_endocrine/exocrine_gland_phen	2.03032781
12	MP0003943_abnormal_hepatobiliary_system	1.72853042
13	MP0001502_abnormal_circadian_rhythm	1.71639052
14	MP0003122_maternal_imprinting	1.63692814
15	MP0005551_abnormal_eye_electrophysiolog	1.57896560
16	MP0002160_abnormal_reproductive_system	1.49022495
17	MP0010386_abnormal_urinary_bladder	1.44417861
18	MP0006082_CNS_inflammation	1.27500672
19	MP0003195_calcinosis	1.19403999
20	MP0002138_abnormal_hepatobiliary_system	1.18203249
21	MP0004043_abnormal_pH_regulation	1.08713015
22	MP0001905_abnormal_dopamine_level	1.07728814
23	MP0005391_vision/eye_phenotype	1.07178395
24	MP0008961_abnormal_basal_metabolism	1.06695441
25	MP0009384_cardiac_valve_regurgitation	1.02716887
26	MP0002909_abnormal_adrenal_gland	1.02061344
27	MP0004019_abnormal_vitamin_homeostasis	0.96640762
28	MP0001529_abnormal_vocalization	0.92711265
29	MP0005220_abnormal_exocrine_pancreas	0.91023721
30	MP0004859_abnormal_synaptic_plasticity	0.89813039
31	MP0003136_yellow_coat_color	0.89196294
32	MP0005595_abnormal_vascular_smooth	0.84329070
33	MP0000569_abnormal_digit_pigmentation	0.83787789
34	MP0003868_abnormal_feces_composition	0.83184371
35	MP0002184_abnormal_innervation	0.80443644
36	MP0003646_muscle_fatigue	0.80388467
37	MP0000538_abnormal_urinary_bladder	0.80245727
38	MP0002064_seizures	0.79721603
39	MP0002102_abnormal_ear_morphology	0.79178574
40	MP0002572_abnormal_emotion/affect_behav	0.79092140
41	MP0008877_abnormal_DNA_methylation	0.77809264
42	MP0005423_abnormal_somatic_nervous	0.77616399
43	MP0009780_abnormal_chondrocyte_physiolo	0.77059075
44	MP0009046_muscle_twitch	0.76719348
45	MP0008775_abnormal_heart_ventricle	0.76083918
46	MP0009745_abnormal_behavioral_response	0.73484597
47	MP0009672_abnormal_birth_weight	0.72677040
48	MP0005389_reproductive_system_phenotype	0.71977977
49	MP0000230_abnormal_systemic_arterial	0.69741743
50	MP0003950_abnormal_plasma_membrane	0.69347278
51	MP0004133_heterotaxia	0.68232437
52	MP0002752_abnormal_somatic_nervous	0.67804874
53	MP0002837_dystrophic_cardiac_calcinosis	0.66679436
54	MP0000427_abnormal_hair_cycle	0.65714084
55	MP0005195_abnormal_posterior_eye	0.64914009
56	MP0004215_abnormal_myocardial_fiber	0.61893924
57	MP0005167_abnormal_blood-brain_barrier	0.61428349
58	MP0003566_abnormal_cell_adhesion	0.60882029
59	MP0008875_abnormal_xenobiotic_pharmacok	0.60204430
60	MP0001501_abnormal_sleep_pattern	0.58887557
61	MP0003252_abnormal_bile_duct	0.58686319
62	MP0001440_abnormal_grooming_behavior	0.57789020
63	MP0005376_homeostasis/metabolism_phenot	0.56577396
64	MP0001958_emphysema	0.55459472
65	MP0002272_abnormal_nervous_system	0.55125940
66	MP0003121_genomic_imprinting	0.54173474
67	MP0002234_abnormal_pharynx_morphology	0.53657454
68	MP0005397_hematopoietic_system_phenotyp	0.51354492
69	MP0001545_abnormal_hematopoietic_system	0.51354492
70	MP0002733_abnormal_thermal_nociception	0.51253654
71	MP0002735_abnormal_chemical_nociception	0.51208369
72	MP0000639_abnormal_adrenal_gland	0.50939397
73	MP0003656_abnormal_erythrocyte_physiolo	0.50286242
74	MP0002063_abnormal_learning/memory/cond	0.48819564
75	MP0000778_abnormal_nervous_system	0.48204336
76	MP0004130_abnormal_muscle_cell	0.45953175
77	MP0003137_abnormal_impulse_conducting	0.45259500
78	MP0003283_abnormal_digestive_organ	0.42915932
79	MP0008058_abnormal_DNA_repair	0.39265820
80	MP0003279_aneurysm	0.38008014
81	MP0002932_abnormal_joint_morphology	0.37600961
82	MP0003806_abnormal_nucleotide_metabolis	0.37485116
83	MP0008874_decreased_physiological_sensi	0.36912171
84	MP0003183_abnormal_peptide_metabolism	0.35976595
85	MP0003693_abnormal_embryo_hatching	0.35842711
86	MP0006276_abnormal_autonomic_nervous	0.35376731
87	MP0001486_abnormal_startle_reflex	0.33403100
88	MP0002229_neurodegeneration	0.33192398
89	MP0003221_abnormal_cardiomyocyte_apopto	0.33162861
90	MP0001188_hyperpigmentation	0.32913226
91	MP0002882_abnormal_neuron_morphology	0.31945855
92	MP0000465_gastrointestinal_hemorrhage	0.31795970
93	MP0004142_abnormal_muscle_tone	0.31519634
94	MP0005310_abnormal_salivary_gland	0.30865497
95	MP0000955_abnormal_spinal_cord	0.29861090
96	MP0003635_abnormal_synaptic_transmissio	0.29648517
97	MP0001919_abnormal_reproductive_system	0.28834214
98	MP0003718_maternal_effect	0.28537904
99	MP0004484_altered_response_of	0.28020301
100	MP0005452_abnormal_adipose_tissue	0.27740738

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Azoospermia (HP:0000027)	6.76283949
2	Abnormal hair whorl (HP:0010721)	5.97323044
3	Amyotrophic lateral sclerosis (HP:0007354)	5.80510357
4	Broad face (HP:0000283)	5.67890190
5	Abnormal spermatogenesis (HP:0008669)	5.40531857
6	Abnormality of the lower motor neuron (HP:0002366)	4.89558397
7	Upper motor neuron abnormality (HP:0002127)	4.80800218
8	Atrophy/Degeneration involving motor neurons (HP:0007373)	4.71065489
9	Tetraplegia (HP:0002445)	4.67772619
10	Hand muscle atrophy (HP:0009130)	4.04934242
11	Spastic tetraparesis (HP:0001285)	3.93739435
12	Progressive inability to walk (HP:0002505)	3.92353456
13	Abnormality of the corticospinal tract (HP:0002492)	3.91927740
14	Pancreatic cysts (HP:0001737)	3.89880573
15	Chronic hepatic failure (HP:0100626)	3.65848025
16	Akinesia (HP:0002304)	3.61130583
17	Abnormality of the renal cortex (HP:0011035)	3.46128050
18	Increased IgE level (HP:0003212)	3.42407820
19	Pseudobulbar signs (HP:0002200)	3.22344758
20	Tubular atrophy (HP:0000092)	3.16010599
21	Abnormality of midbrain morphology (HP:0002418)	3.08769389
22	Molar tooth sign on MRI (HP:0002419)	3.08769389
23	Hypoplastic ischia (HP:0003175)	3.08726006
24	Prominent supraorbital ridges (HP:0000336)	3.05429716
25	Distal upper limb amyotrophy (HP:0007149)	2.92409901
26	Upper limb amyotrophy (HP:0009129)	2.92409901
27	Spastic tetraplegia (HP:0002510)	2.91173020
28	Nephronophthisis (HP:0000090)	2.89664387
29	Congenital stationary night blindness (HP:0007642)	2.86429388
30	Inability to walk (HP:0002540)	2.83927249
31	Absent/shortened dynein arms (HP:0200106)	2.83021175
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.83021175
33	Degeneration of anterior horn cells (HP:0002398)	2.80856452
34	Abnormality of the anterior horn cell (HP:0006802)	2.80856452
35	Volvulus (HP:0002580)	2.79858700
36	Short 4th metacarpal (HP:0010044)	2.75817155
37	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.75817155
38	Achilles tendon contracture (HP:0001771)	2.72390797
39	Broad hallux (HP:0010055)	2.72260355
40	Enlarged epiphyses (HP:0010580)	2.71598813
41	True hermaphroditism (HP:0010459)	2.66486983
42	Abnormality of the ischium (HP:0003174)	2.59870594
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.58491649
44	Type II diabetes mellitus (HP:0005978)	2.57850331
45	Renal cortical cysts (HP:0000803)	2.57396277
46	Increased number of teeth (HP:0011069)	2.55479735
47	Generalized aminoaciduria (HP:0002909)	2.54559844
48	Pancreatic fibrosis (HP:0100732)	2.54448263
49	Morphological abnormality of the pyramidal tract (HP:0002062)	2.48547948
50	Abnormality of the Achilles tendon (HP:0005109)	2.46133583
51	Stomach cancer (HP:0012126)	2.45433552
52	Diminished movement (HP:0002374)	2.44365825
53	Downturned corners of mouth (HP:0002714)	2.41561779
54	Drooling (HP:0002307)	2.37626434
55	Abolished electroretinogram (ERG) (HP:0000550)	2.36605500
56	Abnormality of the 4th metacarpal (HP:0010012)	2.33351286
57	Abnormality of the renal medulla (HP:0100957)	2.24617292
58	Abnormal neuron morphology (HP:0012757)	2.23703483
59	Abnormality of the motor neurons (HP:0002450)	2.23703483
60	Cutaneous finger syndactyly (HP:0010554)	2.20504540
61	Excessive salivation (HP:0003781)	2.19791534
62	Abnormal auditory evoked potentials (HP:0006958)	2.19311661
63	Proximal tubulopathy (HP:0000114)	2.13766764
64	Opisthotonus (HP:0002179)	2.13658195
65	Wide intermamillary distance (HP:0006610)	2.12769919
66	Broad toe (HP:0001837)	2.11162103
67	Adactyly (HP:0009776)	2.10326691
68	Photophobia (HP:0000613)	2.02689213
69	Congenital sensorineural hearing impairment (HP:0008527)	2.02426894
70	Hematochezia (HP:0002573)	1.99004722
71	Palpebral edema (HP:0100540)	1.96804434
72	Recurrent gram-negative bacterial infections (HP:0005420)	1.95552548
73	Concave nail (HP:0001598)	1.93672919
74	Colon cancer (HP:0003003)	1.93619853
75	Bile duct proliferation (HP:0001408)	1.90600572
76	Abnormal biliary tract physiology (HP:0012439)	1.90600572
77	Cystic liver disease (HP:0006706)	1.88261389
78	Poor speech (HP:0002465)	1.85721014
79	Short foot (HP:0001773)	1.85620437
80	Anencephaly (HP:0002323)	1.85487031
81	Childhood onset (HP:0011463)	1.85224627
82	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.84115504
83	Abnormal respiratory epithelium morphology (HP:0012253)	1.83397907
84	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83397907
85	Tongue fasciculations (HP:0001308)	1.81960732
86	Spontaneous hematomas (HP:0007420)	1.81910707
87	Postural instability (HP:0002172)	1.80770017
88	Ependymoma (HP:0002888)	1.80713049
89	Attenuation of retinal blood vessels (HP:0007843)	1.76254310
90	Sclerocornea (HP:0000647)	1.75194235
91	Amelogenesis imperfecta (HP:0000705)	1.72382053
92	Type II lissencephaly (HP:0007260)	1.72353183
93	Short tibia (HP:0005736)	1.72318985
94	Urethral obstruction (HP:0000796)	1.71916559
95	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.71779677
96	Abnormality of ocular smooth pursuit (HP:0000617)	1.69976223
97	Bony spicule pigmentary retinopathy (HP:0007737)	1.69678332
98	Conjunctival telangiectasia (HP:0000524)	1.66610687
99	Furrowed tongue (HP:0000221)	1.65722572
100	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.65413246

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.89104694
2	PIK3CG	3.06626893
3	NUAK1	2.31009494
4	ERBB3	2.26204879
5	LIMK1	2.16059550
6	EIF2AK1	2.14348755
7	PINK1	2.12611677
8	MAP3K9	2.06656825
9	NME1	11.6136638
10	MAP3K4	1.94463088
11	TAOK3	1.83815604
12	GRK1	1.82545869
13	NEK9	1.66531706
14	TSSK6	1.61089890
15	MAP2K7	1.53124313
16	MAP3K6	1.46710973
17	SIK2	1.44431388
18	TESK1	1.43742559
19	PIM2	1.41852535
20	PASK	1.37892355
21	MAPK13	1.37196098
22	ARAF	1.26939117
23	LATS1	1.26029561
24	CAMKK2	1.23404589
25	PNCK	1.22147424
26	TIE1	1.17973662
27	NTRK2	1.12179088
28	ADRBK2	1.07922393
29	EIF2AK3	1.06823954
30	NTRK3	1.00879397
31	ACVR1B	0.95164056
32	TLK1	0.89614442
33	OXSR1	0.86418962
34	PTK2B	0.81365448
35	WNK3	0.79406914
36	DAPK2	0.78190426
37	BCR	0.78114315
38	BRSK2	0.75886045
39	MARK1	0.74573818
40	MAPKAPK5	0.73864069
41	PRKCQ	0.71533289
42	BMPR1B	0.71167475
43	AURKA	0.68217296
44	TGFBR1	0.65438611
45	OBSCN	0.64303610
46	MAP2K4	0.58406478
47	PIK3CA	0.57912633
48	TEC	0.55478984
49	PRKAA2	0.53564764
50	ROCK1	0.53375029
51	RAF1	0.52865454
52	STK39	0.52057268
53	ZAK	0.52026537
54	PRKCG	0.50510003
55	MAPKAPK3	0.50466045
56	CSNK1G2	0.48942134
57	PHKG2	0.48377504
58	PHKG1	0.48377504
59	WNK4	0.47060738
60	CASK	0.46310172
61	CAMKK1	0.46100698
62	MAPK15	0.46022614
63	WEE1	0.41991687
64	NEK6	0.41205564
65	MAP4K2	0.41143145
66	CAMK1D	0.41094719
67	FLT3	0.40727212
68	MET	0.36793355
69	RPS6KA5	0.36757216
70	CAMK4	0.35781859
71	INSRR	0.35053664
72	PKN1	0.34841441
73	STK38L	0.34600641
74	ADRBK1	0.33206449
75	PLK4	0.32319204
76	PRKACA	0.31662780
77	CDK1	0.31618473
78	CAMK1	0.30796413
79	DYRK2	0.29773638
80	RPS6KA6	0.29501863
81	EEF2K	0.29460977
82	MARK3	0.28307806
83	PRKCB	0.27569428
84	PRKCE	0.23775660
85	PRKAA1	0.21551608
86	EGFR	0.20575802
87	BRAF	0.20190723
88	BRD4	0.19930658
89	RPS6KB1	0.19593308
90	CDK5	0.18040188
91	CAMK2A	0.17939309
92	CDK19	0.16676266
93	PRKCH	0.16030059
94	PAK6	0.15302466
95	CSNK1G3	0.14576396
96	PAK3	0.14305627
97	MAPK9	0.13131716
98	PRKACB	0.12357166
99	PRKD3	0.12169150
100	PDGFRB	0.11744112

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	5.37343367
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.32752271
3	One carbon pool by folate_Homo sapiens_hsa00670	3.04823441
4	Retinol metabolism_Homo sapiens_hsa00830	2.97024617
5	Inositol phosphate metabolism_Homo sapiens_hsa00562	2.96788083
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.81234173
7	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.65232923
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.57531897
9	Phototransduction_Homo sapiens_hsa04744	2.52944778
10	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	2.21175217
11	Regulation of autophagy_Homo sapiens_hsa04140	2.10360400
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.00076018
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.87149858
14	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.83089168
15	Nicotine addiction_Homo sapiens_hsa05033	1.82764050
16	Histidine metabolism_Homo sapiens_hsa00340	1.72574598
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.69346671
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67225305
19	ABC transporters_Homo sapiens_hsa02010	1.61114796
20	Taste transduction_Homo sapiens_hsa04742	1.60885794
21	Morphine addiction_Homo sapiens_hsa05032	1.59604358
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.58911540
23	Basal transcription factors_Homo sapiens_hsa03022	1.58744499
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.52468248
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.44281264
26	Olfactory transduction_Homo sapiens_hsa04740	1.39194076
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.36826687
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31838158
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28483238
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27635613
31	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.22120207
32	Butanoate metabolism_Homo sapiens_hsa00650	1.16823275
33	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.13450999
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.10176846
35	Gastric acid secretion_Homo sapiens_hsa04971	1.05783383
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05599914
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03972992
38	Bile secretion_Homo sapiens_hsa04976	1.03268438
39	PPAR signaling pathway_Homo sapiens_hsa03320	1.00873453
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94889858
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93125376
42	Salivary secretion_Homo sapiens_hsa04970	0.90062288
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89133221
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.88023048
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.87647069
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86113337
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81819878
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.80949064
49	GABAergic synapse_Homo sapiens_hsa04727	0.80926525
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80598201
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.80185122
52	Lysine degradation_Homo sapiens_hsa00310	0.77995594
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75327069
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74029124
55	Caffeine metabolism_Homo sapiens_hsa00232	0.72102819
56	Homologous recombination_Homo sapiens_hsa03440	0.68887319
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65347466
58	Huntingtons disease_Homo sapiens_hsa05016	0.62195829
59	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61123860
60	Metabolic pathways_Homo sapiens_hsa01100	0.60708306
61	Insulin secretion_Homo sapiens_hsa04911	0.60604024
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58721704
63	Circadian rhythm_Homo sapiens_hsa04710	0.57982688
64	Fatty acid degradation_Homo sapiens_hsa00071	0.57439750
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54135332
66	RNA degradation_Homo sapiens_hsa03018	0.53661404
67	Cholinergic synapse_Homo sapiens_hsa04725	0.52486927
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51557774
69	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.50707335
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50613139
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48076860
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.46704303
73	Circadian entrainment_Homo sapiens_hsa04713	0.45634025
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45238893
75	Complement and coagulation cascades_Homo sapiens_hsa04610	0.45010191
76	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42960102
77	Glutathione metabolism_Homo sapiens_hsa00480	0.42802335
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42621789
79	Oxidative phosphorylation_Homo sapiens_hsa00190	0.41098223
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.39877645
81	Parkinsons disease_Homo sapiens_hsa05012	0.39262735
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38328728
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.37611273
84	African trypanosomiasis_Homo sapiens_hsa05143	0.36218401
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34071844
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31925219
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.31317144
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31310665
89	Serotonergic synapse_Homo sapiens_hsa04726	0.30587045
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29941693
91	Alzheimers disease_Homo sapiens_hsa05010	0.29242004
92	Purine metabolism_Homo sapiens_hsa00230	0.28701215
93	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.27771271
94	Ras signaling pathway_Homo sapiens_hsa04014	0.23296446
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22909766
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.21625327
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.21033414
98	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.19602274
99	Pancreatic secretion_Homo sapiens_hsa04972	0.18968975
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.17451906

RBM22P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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