RBM24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.49057944
2cardiac myofibril assembly (GO:0055003)8.13972265
3actin-myosin filament sliding (GO:0033275)8.11509742
4muscle filament sliding (GO:0030049)8.11509742
5myofibril assembly (GO:0030239)7.61225218
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.48405597
7actin-mediated cell contraction (GO:0070252)6.81994260
8negative regulation of potassium ion transmembrane transport (GO:1901380)6.75001376
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.49527789
10cardiac muscle contraction (GO:0060048)6.45084746
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.32131786
12regulation of skeletal muscle contraction (GO:0014819)6.13130283
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.12781727
14cardiac muscle cell development (GO:0055013)6.02464632
15cardiac cell development (GO:0055006)5.67549328
16cardiac muscle hypertrophy (GO:0003300)5.65027682
17actomyosin structure organization (GO:0031032)5.63974190
18striated muscle contraction (GO:0006941)5.62820732
19regulation of sarcomere organization (GO:0060297)5.58692886
20response to muscle activity (GO:0014850)5.58118032
21sarcoplasmic reticulum calcium ion transport (GO:0070296)5.57202853
22regulation of actin filament-based movement (GO:1903115)5.53637610
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.53279452
24plasma membrane repair (GO:0001778)5.51239817
25regulation of relaxation of muscle (GO:1901077)5.47508346
26cardiac muscle tissue morphogenesis (GO:0055008)5.44829776
27striated muscle hypertrophy (GO:0014897)5.39997262
28tricarboxylic acid cycle (GO:0006099)5.33563739
29regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.22417950
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.18714447
31adult heart development (GO:0007512)5.17831289
32regulation of cell communication by electrical coupling (GO:0010649)5.11050016
33actin filament-based movement (GO:0030048)5.10239712
34ventricular cardiac muscle cell action potential (GO:0086005)5.05177011
35heart trabecula formation (GO:0060347)5.02255417
36muscle tissue morphogenesis (GO:0060415)5.00380187
37ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.00312988
38creatine metabolic process (GO:0006600)4.95878628
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.83393329
40regulation of striated muscle contraction (GO:0006942)4.76639192
41muscle hypertrophy (GO:0014896)4.71759946
42heart process (GO:0003015)4.70376253
43heart contraction (GO:0060047)4.70376253
44response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.69280278
45skeletal muscle fiber development (GO:0048741)4.68307632
46negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.61309952
47regulation of membrane repolarization (GO:0060306)4.61052746
48regulation of acyl-CoA biosynthetic process (GO:0050812)4.58867116
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.57619716
50carnitine shuttle (GO:0006853)4.54448829
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44726533
52myotube cell development (GO:0014904)4.44573627
53skeletal muscle contraction (GO:0003009)4.43271690
54regulation of the force of heart contraction (GO:0002026)4.37457336
55cardiac muscle hypertrophy in response to stress (GO:0014898)4.28669282
56muscle hypertrophy in response to stress (GO:0003299)4.28669282
57cardiac muscle adaptation (GO:0014887)4.28669282
58bundle of His cell to Purkinje myocyte communication (GO:0086069)4.24398123
59skeletal muscle adaptation (GO:0043501)4.21925571
60regulation of cofactor metabolic process (GO:0051193)4.21269486
61regulation of coenzyme metabolic process (GO:0051196)4.21269486
62cell communication involved in cardiac conduction (GO:0086065)4.19902058
63energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13795299
64ATP synthesis coupled proton transport (GO:0015986)4.13795299
65response to inactivity (GO:0014854)4.06825515
66cell communication by electrical coupling (GO:0010644)4.00191126
67NADH metabolic process (GO:0006734)3.98665502
68negative regulation of striated muscle cell apoptotic process (GO:0010664)3.97757477
69skeletal muscle tissue development (GO:0007519)3.97259091
70muscle cell fate commitment (GO:0042693)3.91923718
71negative regulation of protein localization to cell surface (GO:2000009)3.91521247
72striated muscle cell development (GO:0055002)3.89116418
73muscle contraction (GO:0006936)3.82938787
74cardiac muscle cell action potential (GO:0086001)3.82324259
75fatty acid transmembrane transport (GO:1902001)3.81100952
76cardiac muscle cell action potential involved in contraction (GO:0086002)3.80571334
77regulation of cardiac muscle contraction (GO:0055117)3.79711571
78regulation of heart rate (GO:0002027)3.78279164
79striated muscle adaptation (GO:0014888)3.78103158
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.76051788
81negative regulation of potassium ion transport (GO:0043267)3.70274536
82regulation of cardiac muscle cell contraction (GO:0086004)3.70008908
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67685728
84respiratory electron transport chain (GO:0022904)3.64111724
85glycogen catabolic process (GO:0005980)3.62638952
86regulation of cardioblast differentiation (GO:0051890)3.60084336
87ventricular cardiac muscle cell development (GO:0055015)3.59965318
88muscle system process (GO:0003012)3.57652467
89cardiac conduction (GO:0061337)3.55610578
90electron transport chain (GO:0022900)3.54046868
91muscle organ development (GO:0007517)3.53655011
92muscle structure development (GO:0061061)3.53619531
93cardiac chamber formation (GO:0003207)3.52852726
94relaxation of cardiac muscle (GO:0055119)3.52470507
95glycogen biosynthetic process (GO:0005978)3.52067200
96glucan biosynthetic process (GO:0009250)3.52067200
97regulation of calcium ion transmembrane transport (GO:1903169)3.46561231
98regulation of calcium ion transmembrane transporter activity (GO:1901019)3.46561231
99striated muscle atrophy (GO:0014891)3.44707629
100regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43744159
101regulation of heart contraction (GO:0008016)3.43520143
102regulation of muscle system process (GO:0090257)3.43070175
103regulation of ATPase activity (GO:0043462)3.40068184
104regulation of ATP catabolic process (GO:1903289)3.40068184
105regulation of sulfur metabolic process (GO:0042762)3.39612393
106oxidative phosphorylation (GO:0006119)3.39375099
107regulation of heart rate by cardiac conduction (GO:0086091)3.37902293
108muscle adaptation (GO:0043500)3.37618772
109glucan catabolic process (GO:0009251)3.37241522
110regulation of muscle contraction (GO:0006937)3.36507951
111positive regulation of myotube differentiation (GO:0010831)3.36279230
112muscle cell development (GO:0055001)3.36125263
113muscle fiber development (GO:0048747)3.35941966
114membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35632825
115regulation of striated muscle cell apoptotic process (GO:0010662)3.31893950
116muscle cell cellular homeostasis (GO:0046716)3.31773704
117negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.27148716
118negative regulation of calcium ion transmembrane transport (GO:1903170)3.27148716
119positive regulation of cation channel activity (GO:2001259)3.26807420
120carnitine transmembrane transport (GO:1902603)3.26533122
121relaxation of muscle (GO:0090075)3.25858855
122trabecula formation (GO:0060343)3.25624781
123regulation of myoblast differentiation (GO:0045661)3.23610310
124positive regulation of myoblast differentiation (GO:0045663)3.19170799
125skeletal muscle tissue regeneration (GO:0043403)3.17989447
126striated muscle tissue development (GO:0014706)3.17652194
127cellular polysaccharide catabolic process (GO:0044247)3.13591994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EP300_21415370_ChIP-Seq_HL-1_Mouse4.48577431
2EZH2_22144423_ChIP-Seq_EOC_Human4.19486509
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.62730422
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.49396467
5* TBX20_22080862_ChIP-Seq_HEART_Mouse3.06987516
6* TBX20_22328084_ChIP-Seq_HEART_Mouse3.06987516
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.05041336
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.90973672
9* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.70699650
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48026820
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39558874
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24090924
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18063397
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08687960
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.03046294
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99414350
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99414350
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96748419
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.89462965
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85169104
21ZNF274_21170338_ChIP-Seq_K562_Hela1.83619872
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81282331
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81001970
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78328712
25GATA4_21415370_ChIP-Seq_HL-1_Mouse1.76857573
26ZNF263_19887448_ChIP-Seq_K562_Human1.68200457
27DROSHA_22980978_ChIP-Seq_HELA_Human1.62832421
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.62206269
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60596468
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.59065594
31ISL1_27105846_Chip-Seq_CPCs_Mouse1.54425293
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54101825
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.47628076
34* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47439486
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46915551
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43814385
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43221010
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39750696
39* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39462868
40GBX2_23144817_ChIP-Seq_PC3_Human1.36185370
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35356220
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.34029148
43* RARB_27405468_Chip-Seq_BRAIN_Mouse1.29906356
44VDR_22108803_ChIP-Seq_LS180_Human1.28605408
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27815895
46* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25765703
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24293449
48SMAD4_21799915_ChIP-Seq_A2780_Human1.22708050
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22342904
50TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21433908
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21378188
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21222030
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18708506
54BCAT_22108803_ChIP-Seq_LS180_Human1.18327390
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16559544
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14276518
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12817144
58AHR_22903824_ChIP-Seq_MCF-7_Human1.10959726
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09919491
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09649856
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08986944
62IGF1R_20145208_ChIP-Seq_DFB_Human1.08076692
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08040907
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07427413
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.07302949
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.04971060
67CTCF_27219007_Chip-Seq_Bcells_Human1.03889325
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02918439
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.02737598
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01680889
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00830703
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00733244
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00584414
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.00451773
75NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99598629
76AR_19668381_ChIP-Seq_PC3_Human0.99489248
77TP53_16413492_ChIP-PET_HCT116_Human0.99423911
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99334836
79ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99282056
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99019332
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.98891628
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.95822197
83* WT1_19549856_ChIP-ChIP_CCG9911_Human0.95158831
84AR_21572438_ChIP-Seq_LNCaP_Human0.94915929
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94871580
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94662854
87* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94360225
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94335405
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94305310
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94197815
91* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94148352
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93956662
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.93454875
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93293153
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.92135554
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90923606
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90871254
98SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90649470
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90469271
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.90151233
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90045893
102CJUN_26792858_Chip-Seq_BT549_Human0.89986227
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89927355
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89147022
105CLOCK_20551151_ChIP-Seq_293T_Human0.88540043
106GATA1_22025678_ChIP-Seq_K562_Human0.88372960
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88307244
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87435494
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87384183
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86975710
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.86307127
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86170027
113TP53_18474530_ChIP-ChIP_U2OS_Human0.85915977
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85915828
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85523412
116PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84469946
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83224150
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80533961
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80533961
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80314317
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79661208
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79390655
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79233999
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77038063
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75589966
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75527014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.87851161
2MP0004084_abnormal_cardiac_muscle5.42979440
3MP0000751_myopathy5.09877608
4MP0003646_muscle_fatigue4.78358183
5MP0000749_muscle_degeneration4.62825103
6MP0004036_abnormal_muscle_relaxation4.42164979
7MP0004215_abnormal_myocardial_fiber4.39088178
8MP0005330_cardiomyopathy3.75813407
9MP0004145_abnormal_muscle_electrophysio3.67516119
10MP0004087_abnormal_muscle_fiber3.21515701
11MP0002972_abnormal_cardiac_muscle3.11393950
12MP0005620_abnormal_muscle_contractility3.00130943
13MP0003137_abnormal_impulse_conducting2.89277927
14MP0002106_abnormal_muscle_physiology2.88669830
15MP0000750_abnormal_muscle_regeneration2.71951734
16MP0008775_abnormal_heart_ventricle2.63956199
17MP0010630_abnormal_cardiac_muscle2.48478499
18MP0002269_muscular_atrophy2.43684194
19MP0004484_altered_response_of2.42986472
20MP0005385_cardiovascular_system_phenoty2.39777664
21MP0001544_abnormal_cardiovascular_syste2.39777664
22MP0005369_muscle_phenotype2.38629131
23MP0000747_muscle_weakness2.36261769
24MP0000759_abnormal_skeletal_muscle2.28016863
25MP0006138_congestive_heart_failure2.27446926
26MP0004130_abnormal_muscle_cell2.25203896
27MP0004085_abnormal_heartbeat2.24161227
28MP0003828_pulmonary_edema2.02583438
29MP0004233_abnormal_muscle_weight2.00417140
30MP0002127_abnormal_cardiovascular_syste1.85412568
31MP0004510_myositis1.81915186
32MP0003221_abnormal_cardiomyocyte_apopto1.81702727
33MP0003950_abnormal_plasma_membrane1.62110258
34MP0003567_abnormal_fetal_cardiomyocyte1.43345403
35MP0006036_abnormal_mitochondrial_physio1.41840510
36MP0002234_abnormal_pharynx_morphology1.34778714
37MP0002332_abnormal_exercise_endurance1.34138231
38MP0002108_abnormal_muscle_morphology1.16240135
39MP0000733_abnormal_muscle_development1.15293384
40MP0000266_abnormal_heart_morphology1.12133149
41MP0001661_extended_life_span1.11326471
42MP0005623_abnormal_meninges_morphology0.98915985
43MP0006035_abnormal_mitochondrial_morpho0.93680086
44MP0010368_abnormal_lymphatic_system0.88174536
45MP0003122_maternal_imprinting0.86816178
46MP0003279_aneurysm0.80534728
47MP0005666_abnormal_adipose_tissue0.80013583
48MP0005165_increased_susceptibility_to0.78068374
49MP0004270_analgesia0.71837825
50MP0009384_cardiac_valve_regurgitation0.71592149
51MP0000230_abnormal_systemic_arterial0.71406665
52MP0010030_abnormal_orbit_morphology0.71384437
53MP0002128_abnormal_blood_circulation0.70847038
54MP0008438_abnormal_cutaneous_collagen0.70767719
55MP0000343_altered_response_to0.67383283
56MP0004272_abnormal_basement_membrane0.66940722
57MP0000013_abnormal_adipose_tissue0.66604561
58MP0005187_abnormal_penis_morphology0.63179962
59MP0005266_abnormal_metabolism0.62534141
60MP0009250_abnormal_appendicular_skeleto0.60393479
61MP0005375_adipose_tissue_phenotype0.57529819
62MP0003045_fibrosis0.57501986
63MP0005451_abnormal_body_composition0.55705832
64MP0001879_abnormal_lymphatic_vessel0.55605150
65MP0002909_abnormal_adrenal_gland0.55104213
66MP0003705_abnormal_hypodermis_morpholog0.52450175
67MP0002925_abnormal_cardiovascular_devel0.51538058
68MP0004859_abnormal_synaptic_plasticity0.51517001
69MP0002971_abnormal_brown_adipose0.51358706
70MP0004185_abnormal_adipocyte_glucose0.50879777
71MP0005275_abnormal_skin_tensile0.50658047
72MP0005377_hearing/vestibular/ear_phenot0.50130449
73MP0003878_abnormal_ear_physiology0.50130449
74MP0004134_abnormal_chest_morphology0.48809111
75MP0000767_abnormal_smooth_muscle0.47637791
76MP0009780_abnormal_chondrocyte_physiolo0.45759297
77MP0000534_abnormal_ureter_morphology0.45526528
78MP0002822_catalepsy0.44349120
79MP0005670_abnormal_white_adipose0.43503796
80MP0003385_abnormal_body_wall0.43338731
81MP0003123_paternal_imprinting0.43303790
82MP0001784_abnormal_fluid_regulation0.42954040
83MP0001485_abnormal_pinna_reflex0.42549389
84MP0000003_abnormal_adipose_tissue0.42398957
85MP0003880_abnormal_central_pattern0.42350420
86MP0003948_abnormal_gas_homeostasis0.42080639
87MP0002638_abnormal_pupillary_reflex0.41585193
88MP0008961_abnormal_basal_metabolism0.41278585
89MP0005386_behavior/neurological_phenoty0.41165380
90MP0004924_abnormal_behavior0.41165380
91MP0003566_abnormal_cell_adhesion0.41116771
92MP0003941_abnormal_skin_development0.39169551
93MP0002114_abnormal_axial_skeleton0.39095735
94MP0005423_abnormal_somatic_nervous0.38740751
95MP0003121_genomic_imprinting0.38261139
96MP0005503_abnormal_tendon_morphology0.38195467
97MP0002896_abnormal_bone_mineralization0.37342807
98MP0004043_abnormal_pH_regulation0.35790167
99MP0001299_abnormal_eye_distance/0.34511231
100MP0001529_abnormal_vocalization0.34471210
101MP0003984_embryonic_growth_retardation0.33788875
102MP0002088_abnormal_embryonic_growth/wei0.33737635
103MP0000372_irregular_coat_pigmentation0.32596980
104MP0003635_abnormal_synaptic_transmissio0.32443565
105MP0001614_abnormal_blood_vessel0.31619114
106MP0005409_darkened_coat_color0.31176765
107MP0000762_abnormal_tongue_morphology0.30569250
108MP0002734_abnormal_mechanical_nocicepti0.30350980
109MP0002078_abnormal_glucose_homeostasis0.29432831
110MP0008569_lethality_at_weaning0.29381152
111MP0009745_abnormal_behavioral_response0.28757721
112MP0001440_abnormal_grooming_behavior0.27973053
113MP0005595_abnormal_vascular_smooth0.27954857
114MP0002249_abnormal_larynx_morphology0.27594988
115MP0002067_abnormal_sensory_capabilities0.26115733
116MP0005535_abnormal_body_temperature0.25361893
117MP0001943_abnormal_respiration0.24269556
118MP0006276_abnormal_autonomic_nervous0.23964007
119MP0001984_abnormal_olfaction0.23852875
120MP0004147_increased_porphyrin_level0.22489531
121MP0001958_emphysema0.20666273
122MP0004142_abnormal_muscle_tone0.20480147
123MP0003755_abnormal_palate_morphology0.20033809
124MP0009672_abnormal_birth_weight0.19943086

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.66480921
2Calf muscle hypertrophy (HP:0008981)6.85296369
3Exercise-induced myalgia (HP:0003738)6.54169078
4Muscle hypertrophy of the lower extremities (HP:0008968)6.52350712
5Exercise-induced muscle cramps (HP:0003710)6.44469606
6Abnormality of the calf musculature (HP:0001430)5.70393559
7Ventricular tachycardia (HP:0004756)5.69946823
8Muscle fiber splitting (HP:0003555)5.60654183
9Abnormality of the left ventricular outflow tract (HP:0011103)5.43665504
10Subaortic stenosis (HP:0001682)5.43665504
11Atrial fibrillation (HP:0005110)5.38154975
12Primary atrial arrhythmia (HP:0001692)5.06276157
13Supraventricular tachycardia (HP:0004755)4.87840530
14Hyporeflexia of lower limbs (HP:0002600)4.87729361
15Supraventricular arrhythmia (HP:0005115)4.77887862
16Lipoatrophy (HP:0100578)4.70452794
17Myoglobinuria (HP:0002913)4.62408088
18EMG: myopathic abnormalities (HP:0003458)4.54496024
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.51607397
20Muscle fiber inclusion bodies (HP:0100299)4.51545385
21Syncope (HP:0001279)4.48253105
22Type 1 muscle fiber predominance (HP:0003803)4.31105100
23Right ventricular cardiomyopathy (HP:0011663)4.24618766
24Prolonged QT interval (HP:0001657)4.18598928
25Dilated cardiomyopathy (HP:0001644)3.92634589
26Ventricular arrhythmia (HP:0004308)3.87690299
27Nemaline bodies (HP:0003798)3.86000022
28Calcaneovalgus deformity (HP:0001848)3.81166871
29Palpitations (HP:0001962)3.80527865
30Difficulty running (HP:0009046)3.75776762
31Bundle branch block (HP:0011710)3.72344645
32Asymmetric septal hypertrophy (HP:0001670)3.70957790
33Increased connective tissue (HP:0009025)3.62623169
34Rhabdomyolysis (HP:0003201)3.57303250
35Myotonia (HP:0002486)3.46723576
36Absent phalangeal crease (HP:0006109)3.45131493
37Deformed tarsal bones (HP:0008119)3.36065698
38Ventricular fibrillation (HP:0001663)3.26754860
39Heart block (HP:0012722)3.19565571
40Atrioventricular block (HP:0001678)3.06441045
41Abnormal EKG (HP:0003115)3.04333426
42Abnormal atrioventricular conduction (HP:0005150)3.00792339
43Left ventricular hypertrophy (HP:0001712)2.98565578
44Difficulty climbing stairs (HP:0003551)2.94504330
45Distal arthrogryposis (HP:0005684)2.91819524
46Neck muscle weakness (HP:0000467)2.91315741
47Frequent falls (HP:0002359)2.86525170
48Abnormal finger flexion creases (HP:0006143)2.83650390
49Muscle stiffness (HP:0003552)2.81519933
50Acute necrotizing encephalopathy (HP:0006965)2.76146868
51Round ear (HP:0100830)2.75863130
52Abnormal mitochondria in muscle tissue (HP:0008316)2.73731203
53Rimmed vacuoles (HP:0003805)2.67867762
54Increased variability in muscle fiber diameter (HP:0003557)2.63228850
55Abnormality of skeletal muscle fiber size (HP:0012084)2.58004408
56Distal lower limb muscle weakness (HP:0009053)2.55644947
57Popliteal pterygium (HP:0009756)2.55495670
58Abnormality of the neuromuscular junction (HP:0003398)2.52957840
59Fatigable weakness (HP:0003473)2.52957840
60Bulbar palsy (HP:0001283)2.50185640
61Weak cry (HP:0001612)2.47251164
62Mildly elevated creatine phosphokinase (HP:0008180)2.41936699
63Areflexia of lower limbs (HP:0002522)2.35652529
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.32305232
65Progressive macrocephaly (HP:0004481)2.31730999
66Myopathic facies (HP:0002058)2.30686599
67Generalized muscle weakness (HP:0003324)2.27890415
68EMG: neuropathic changes (HP:0003445)2.26632845
69Gowers sign (HP:0003391)2.26199658
70Palmoplantar keratoderma (HP:0000982)2.24761210
71Congenital malformation of the right heart (HP:0011723)2.24260175
72Double outlet right ventricle (HP:0001719)2.24260175
73Abnormality of the calcaneus (HP:0008364)2.20235947
74Acute encephalopathy (HP:0006846)2.19980124
75Scapular winging (HP:0003691)2.18718730
76Hepatic necrosis (HP:0002605)2.16235521
77Exercise intolerance (HP:0003546)2.15360128
78Ragged-red muscle fibers (HP:0003200)2.15137863
79Limb-girdle muscle atrophy (HP:0003797)2.14424204
80Mitochondrial inheritance (HP:0001427)2.12011564
81Hypoplastic ischia (HP:0003175)2.11614904
82Abnormality of the foot musculature (HP:0001436)2.09598201
83Spinal rigidity (HP:0003306)2.05252314
84Abnormality of the shoulder girdle musculature (HP:0001435)2.03260689
85Distal lower limb amyotrophy (HP:0008944)2.02899008
86Slender build (HP:0001533)2.02644220
87Progressive muscle weakness (HP:0003323)2.02138558
88Waddling gait (HP:0002515)2.02114030
89Muscular dystrophy (HP:0003560)2.01973422
90Ulnar deviation of the wrist (HP:0003049)2.01059804
91Increased CSF lactate (HP:0002490)2.00462701
92Ketoacidosis (HP:0001993)1.99906255
93Hyperkalemia (HP:0002153)1.99693639
94Conjunctival hamartoma (HP:0100780)1.99044683
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98239947
96Aplasia of the musculature (HP:0100854)1.97975614
97Type 2 muscle fiber atrophy (HP:0003554)1.96488285
98Hypoplastic heart (HP:0001961)1.94694333
99Hepatocellular necrosis (HP:0001404)1.94612731
100Respiratory insufficiency due to muscle weakness (HP:0002747)1.91193102
101Limited hip movement (HP:0008800)1.90323062
102Pheochromocytoma (HP:0002666)1.90288686
103Proximal amyotrophy (HP:0007126)1.90015447
104Foot dorsiflexor weakness (HP:0009027)1.89523962
105Nuclear cataract (HP:0100018)1.85690331
106Hip contracture (HP:0003273)1.85355240
107Testicular atrophy (HP:0000029)1.85100931
108Sudden cardiac death (HP:0001645)1.84073511
109Abnormality of the ischium (HP:0003174)1.81336836
110Cerebral edema (HP:0002181)1.80161583
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78933346
112Abnormality of alanine metabolism (HP:0010916)1.78933346
113Hyperalaninemia (HP:0003348)1.78933346
114Malignant hyperthermia (HP:0002047)1.78510235
115Limb-girdle muscle weakness (HP:0003325)1.77816721
116Hypoplastic left heart (HP:0004383)1.77213469
117Increased muscle lipid content (HP:0009058)1.76189650
118Muscle fiber atrophy (HP:0100295)1.75436623
119Congestive heart failure (HP:0001635)1.75108429
120Fetal akinesia sequence (HP:0001989)1.73542411
121Facial diplegia (HP:0001349)1.73391187
122Lower limb amyotrophy (HP:0007210)1.68742299
123Steppage gait (HP:0003376)1.67064167
124Abnormality of placental membranes (HP:0011409)1.66998962
125Amniotic constriction ring (HP:0009775)1.66998962
126Metatarsus adductus (HP:0001840)1.65797062
127Long clavicles (HP:0000890)1.62274854
128Ulnar deviation of finger (HP:0009465)1.50774692
129Nonprogressive disorder (HP:0003680)1.49997982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.65612091
2TTN4.94491590
3PHKG13.88966597
4PHKG23.88966597
5MYLK3.83110018
6DMPK3.41313244
7LMTK22.88270458
8PDK32.81432840
9PDK42.81432840
10PKN22.75895188
11STK242.70296722
12NEK12.43022035
13MUSK2.39670187
14PIK3CA2.19683872
15TRIB32.10326812
16ZAK1.82792670
17PDK21.55761527
18PINK11.55048788
19MARK11.52015598
20TIE11.44748298
21ILK1.44247412
22NME11.40273250
23PAK31.31512641
24CDC42BPA1.31261135
25STK38L1.29706242
26BCKDK1.26471002
27CAMK2D1.25595395
28GRK71.18602627
29MAP3K71.18200698
30MAPK121.11365206
31PIK3CG1.08679065
32ROCK11.07964865
33TRPM71.04064681
34PTK2B0.99206317
35PRKD10.96938316
36ERBB30.95318110
37CCNB10.94712892
38INSRR0.92285062
39EPHA40.88748349
40WNK40.87569341
41CAMK2A0.87481611
42DAPK30.83124198
43PRKAA10.74208812
44MAP2K40.72274556
45MAP3K50.71230457
46PRKAA20.68411754
47EEF2K0.65922042
48CAMK10.64656550
49ROCK20.61189955
50MAP2K30.60684712
51CAMK40.60432489
52DYRK1B0.59865758
53PKN10.59492301
54MAP3K40.58941662
55STK380.57971736
56MAPK40.54940391
57KSR10.54930880
58PLK20.53215163
59LIMK10.52947868
60WNK10.52814616
61CAMK2G0.52643217
62PRKACB0.50707248
63STK40.49344346
64PRKCE0.46963654
65STK390.46583703
66PRKACA0.46359455
67MAPKAPK30.46109896
68NTRK30.45458244
69PRKD30.43725088
70PDGFRA0.43673836
71AKT20.43230796
72MAP3K100.42618536
73SGK10.41984500
74TGFBR20.40021539
75FLT30.39954647
76PRKG10.39772445
77TNIK0.39581999
78BLK0.39049953
79RIPK10.38659039
80KSR20.37601078
81EPHB20.36793231
82RPS6KC10.35135769
83RPS6KL10.35135769
84FER0.32974269
85MAP3K60.32060901
86MAP2K10.31366450
87PNCK0.30868255
88MOS0.30500028
89MAP2K60.28245896
90PRKACG0.27741521
91BMPR20.26337110
92PAK60.26134647
93PRPF4B0.26105144
94SGK20.25480543
95MAPK70.25278195
96RPS6KA30.25253576
97CAMK2B0.25161428
98LATS20.24969692
99MAP3K30.24675019
100RPS6KA60.24211617
101PDPK10.23879174
102UHMK10.23150297
103MAPK100.22276004
104ICK0.21563435
105SGK30.21527776
106MTOR0.21219331
107PDK10.19016510
108MAPK110.18818472
109NEK90.18419102
110RPS6KA10.17933701
111RPS6KA20.17728180
112PRKCH0.17515402
113RAF10.14546875
114STK110.14163554
115LATS10.14072355
116AKT30.13904690
117SGK2230.13606557
118SGK4940.13606557
119RPS6KB10.13260917
120EPHA30.12229648
121DDR20.11455390
122SIK10.10368958
123MARK20.10327760

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.19658476
2Cardiac muscle contraction_Homo sapiens_hsa042604.74413508
3Dilated cardiomyopathy_Homo sapiens_hsa054144.09116841
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.02571414
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.38843200
6Parkinsons disease_Homo sapiens_hsa050123.21009329
7Oxidative phosphorylation_Homo sapiens_hsa001903.12124975
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.86865297
9Alzheimers disease_Homo sapiens_hsa050102.53789891
10Propanoate metabolism_Homo sapiens_hsa006402.35418995
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.28984188
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19136508
13Huntingtons disease_Homo sapiens_hsa050162.12758425
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96924389
15Carbon metabolism_Homo sapiens_hsa012001.92075413
16Fatty acid degradation_Homo sapiens_hsa000711.85618048
17cGMP-PKG signaling pathway_Homo sapiens_hsa040221.51405287
18Viral myocarditis_Homo sapiens_hsa054161.46532682
19Oxytocin signaling pathway_Homo sapiens_hsa049211.42647912
20Pyruvate metabolism_Homo sapiens_hsa006201.41376020
21Calcium signaling pathway_Homo sapiens_hsa040201.37938804
22Fatty acid metabolism_Homo sapiens_hsa012121.36293909
23Glucagon signaling pathway_Homo sapiens_hsa049221.34632571
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29300022
25Arginine biosynthesis_Homo sapiens_hsa002201.29169451
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22477333
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16404522
28Circadian entrainment_Homo sapiens_hsa047131.14247098
29Renin secretion_Homo sapiens_hsa049241.08968786
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.08171632
31Pentose phosphate pathway_Homo sapiens_hsa000301.07321957
32Insulin signaling pathway_Homo sapiens_hsa049101.04878007
33Insulin resistance_Homo sapiens_hsa049310.99913850
34Tight junction_Homo sapiens_hsa045300.94186163
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93222718
36Gastric acid secretion_Homo sapiens_hsa049710.90310195
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89034892
38Insulin secretion_Homo sapiens_hsa049110.88633410
39Starch and sucrose metabolism_Homo sapiens_hsa005000.88373841
40Olfactory transduction_Homo sapiens_hsa047400.86906830
41Focal adhesion_Homo sapiens_hsa045100.86288941
42Long-term potentiation_Homo sapiens_hsa047200.84737915
43Circadian rhythm_Homo sapiens_hsa047100.82750266
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81597964
45Biosynthesis of amino acids_Homo sapiens_hsa012300.79070602
46cAMP signaling pathway_Homo sapiens_hsa040240.78717003
47HIF-1 signaling pathway_Homo sapiens_hsa040660.76260871
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.75680677
49Butanoate metabolism_Homo sapiens_hsa006500.73393859
50Taste transduction_Homo sapiens_hsa047420.71687007
51Type II diabetes mellitus_Homo sapiens_hsa049300.71066886
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69319686
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69315979
54Amphetamine addiction_Homo sapiens_hsa050310.68069566
55AMPK signaling pathway_Homo sapiens_hsa041520.67161643
56GnRH signaling pathway_Homo sapiens_hsa049120.64447650
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62464829
58Cholinergic synapse_Homo sapiens_hsa047250.62182828
59Adherens junction_Homo sapiens_hsa045200.60105601
60Morphine addiction_Homo sapiens_hsa050320.58577227
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.58074637
62Dopaminergic synapse_Homo sapiens_hsa047280.57502411
63Fatty acid elongation_Homo sapiens_hsa000620.56426954
64Salivary secretion_Homo sapiens_hsa049700.55948400
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55288423
66Gap junction_Homo sapiens_hsa045400.55099382
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54132774
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53521642
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52309939
70GABAergic synapse_Homo sapiens_hsa047270.50422945
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49893965
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49666808
73Galactose metabolism_Homo sapiens_hsa000520.48493375
74Glutamatergic synapse_Homo sapiens_hsa047240.48374938
75Melanogenesis_Homo sapiens_hsa049160.45725765
76PPAR signaling pathway_Homo sapiens_hsa033200.43544252
77Serotonergic synapse_Homo sapiens_hsa047260.42658117
78ECM-receptor interaction_Homo sapiens_hsa045120.40110967
79Nitrogen metabolism_Homo sapiens_hsa009100.37594409
80Hippo signaling pathway_Homo sapiens_hsa043900.36673067
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36050521
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35401343
83Fructose and mannose metabolism_Homo sapiens_hsa000510.35270283
84Lysine degradation_Homo sapiens_hsa003100.34301572
85Renal cell carcinoma_Homo sapiens_hsa052110.33667449
86Dorso-ventral axis formation_Homo sapiens_hsa043200.33523237
87Bile secretion_Homo sapiens_hsa049760.33521138
88Estrogen signaling pathway_Homo sapiens_hsa049150.33302559
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33215339
90Nicotine addiction_Homo sapiens_hsa050330.32647383
91MAPK signaling pathway_Homo sapiens_hsa040100.32460370
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32171922
93Proteoglycans in cancer_Homo sapiens_hsa052050.32042275
94Protein digestion and absorption_Homo sapiens_hsa049740.30299107
95Amoebiasis_Homo sapiens_hsa051460.30197890
96Basal cell carcinoma_Homo sapiens_hsa052170.30109301
97Long-term depression_Homo sapiens_hsa047300.29954776
98Tyrosine metabolism_Homo sapiens_hsa003500.27394194
99VEGF signaling pathway_Homo sapiens_hsa043700.25926895
100FoxO signaling pathway_Homo sapiens_hsa040680.25917002
101mTOR signaling pathway_Homo sapiens_hsa041500.25730204
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25377738
103Ovarian steroidogenesis_Homo sapiens_hsa049130.25221691
104Phenylalanine metabolism_Homo sapiens_hsa003600.25092401
105Arginine and proline metabolism_Homo sapiens_hsa003300.24291937
106Endometrial cancer_Homo sapiens_hsa052130.23898109
107Pancreatic secretion_Homo sapiens_hsa049720.23686899
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23248306
109Axon guidance_Homo sapiens_hsa043600.22821315
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.21709525
111Hedgehog signaling pathway_Homo sapiens_hsa043400.21591367
112Glioma_Homo sapiens_hsa052140.21268990
113Tryptophan metabolism_Homo sapiens_hsa003800.20901005
114Fatty acid biosynthesis_Homo sapiens_hsa000610.20583595
115Platelet activation_Homo sapiens_hsa046110.20238560
116beta-Alanine metabolism_Homo sapiens_hsa004100.19793404
117Cocaine addiction_Homo sapiens_hsa050300.16441814
118Wnt signaling pathway_Homo sapiens_hsa043100.15535670

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