

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | histone H3-K4 trimethylation (GO:0080182) | 4.57057532 |
| 2 | pre-miRNA processing (GO:0031054) | 4.29008711 |
| 3 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 4.16527506 |
| 4 | mRNA splice site selection (GO:0006376) | 4.08178669 |
| 5 | mitotic sister chromatid cohesion (GO:0007064) | 3.91657503 |
| 6 | kinetochore organization (GO:0051383) | 3.82592069 |
| 7 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.80378867 |
| 8 | poly(A)+ mRNA export from nucleus (GO:0016973) | 3.77133000 |
| 9 | regulation of DNA endoreduplication (GO:0032875) | 3.69949945 |
| 10 | peptidyl-lysine trimethylation (GO:0018023) | 3.56584387 |
| 11 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.52975967 |
| 12 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.52975967 |
| 13 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.52975967 |
| 14 | heterochromatin organization (GO:0070828) | 3.50047035 |
| 15 | kinetochore assembly (GO:0051382) | 3.42825571 |
| 16 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.39755760 |
| 17 | nuclear pore complex assembly (GO:0051292) | 3.39247246 |
| 18 | histone H3-K9 methylation (GO:0051567) | 3.32709359 |
| 19 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.29390799 |
| 20 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.29390799 |
| 21 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.28866809 |
| 22 | regulation of gene silencing by miRNA (GO:0060964) | 3.28866809 |
| 23 | regulation of gene silencing by RNA (GO:0060966) | 3.28866809 |
| 24 | histone H2B ubiquitination (GO:0033523) | 3.28711154 |
| 25 | DNA replication checkpoint (GO:0000076) | 3.28230227 |
| 26 | regulation of RNA export from nucleus (GO:0046831) | 3.25856773 |
| 27 | negative regulation of DNA recombination (GO:0045910) | 3.25225305 |
| 28 | histone H3-K4 methylation (GO:0051568) | 3.23523851 |
| 29 | meiotic chromosome segregation (GO:0045132) | 3.18874483 |
| 30 | protein localization to kinetochore (GO:0034501) | 3.17020057 |
| 31 | microtubule depolymerization (GO:0007019) | 3.14439718 |
| 32 | nuclear pore organization (GO:0006999) | 3.12817348 |
| 33 | ncRNA catabolic process (GO:0034661) | 3.12680169 |
| 34 | regulation of telomere maintenance (GO:0032204) | 3.05615775 |
| 35 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.03578295 |
| 36 | regulation of centrosome cycle (GO:0046605) | 3.03341132 |
| 37 | intra-S DNA damage checkpoint (GO:0031573) | 3.02678456 |
| 38 | resolution of meiotic recombination intermediates (GO:0000712) | 3.02566083 |
| 39 | centriole replication (GO:0007099) | 2.99671890 |
| 40 | negative regulation of histone methylation (GO:0031061) | 2.98755618 |
| 41 | regulation of centrosome duplication (GO:0010824) | 2.97079301 |
| 42 | otic vesicle formation (GO:0030916) | 2.92938372 |
| 43 | centriole assembly (GO:0098534) | 2.90363452 |
| 44 | CENP-A containing nucleosome assembly (GO:0034080) | 2.86767034 |
| 45 | negative regulation of RNA splicing (GO:0033119) | 2.86597596 |
| 46 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.85905168 |
| 47 | DNA strand renaturation (GO:0000733) | 2.85322474 |
| 48 | telomere maintenance via telomerase (GO:0007004) | 2.85129444 |
| 49 | histone H3-K9 modification (GO:0061647) | 2.83307691 |
| 50 | chromatin remodeling at centromere (GO:0031055) | 2.81198561 |
| 51 | neuronal stem cell maintenance (GO:0097150) | 2.77904042 |
| 52 | DNA topological change (GO:0006265) | 2.77812966 |
| 53 | double-strand break repair via homologous recombination (GO:0000724) | 2.77446285 |
| 54 | recombinational repair (GO:0000725) | 2.76706887 |
| 55 | pore complex assembly (GO:0046931) | 2.75457917 |
| 56 | neural tube formation (GO:0001841) | 2.73334676 |
| 57 | rRNA catabolic process (GO:0016075) | 2.73303104 |
| 58 | microtubule organizing center organization (GO:0031023) | 2.72305586 |
| 59 | centrosome organization (GO:0051297) | 2.71909128 |
| 60 | sister chromatid cohesion (GO:0007062) | 2.71158386 |
| 61 | regulation of histone H3-K9 methylation (GO:0051570) | 2.70141298 |
| 62 | regulation of mRNA 3-end processing (GO:0031440) | 2.68312517 |
| 63 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.67945775 |
| 64 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.67945775 |
| 65 | histone-serine phosphorylation (GO:0035404) | 2.67611442 |
| 66 | single strand break repair (GO:0000012) | 2.67411835 |
| 67 | DNA replication-independent nucleosome organization (GO:0034724) | 2.66911852 |
| 68 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.66911852 |
| 69 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.66888560 |
| 70 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.66888560 |
| 71 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.66888560 |
| 72 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.66888560 |
| 73 | negative regulation of sister chromatid segregation (GO:0033046) | 2.66888560 |
| 74 | DNA ligation (GO:0006266) | 2.66693144 |
| 75 | DNA geometric change (GO:0032392) | 2.65149552 |
| 76 | DNA duplex unwinding (GO:0032508) | 2.63045644 |
| 77 | negative regulation of chromosome segregation (GO:0051985) | 2.62336244 |
| 78 | negative regulation of mRNA metabolic process (GO:1903312) | 2.62283291 |
| 79 | histone lysine methylation (GO:0034968) | 2.61672189 |
| 80 | somite development (GO:0061053) | 2.58127972 |
| 81 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.57697049 |
| 82 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.57101117 |
| 83 | regulation of histone H3-K27 methylation (GO:0061085) | 2.56377342 |
| 84 | * regulation of mRNA processing (GO:0050684) | 2.55442603 |
| 85 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.55251959 |
| 86 | forebrain neuron differentiation (GO:0021879) | 2.54809320 |
| 87 | DNA alkylation (GO:0006305) | 2.54179283 |
| 88 | DNA methylation (GO:0006306) | 2.54179283 |
| 89 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.53450750 |
| 90 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.51827712 |
| 91 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.51827712 |
| 92 | mitotic spindle checkpoint (GO:0071174) | 2.51588559 |
| 93 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.51070300 |
| 94 | regulation of spindle checkpoint (GO:0090231) | 2.49399498 |
| 95 | RNA-dependent DNA replication (GO:0006278) | 2.48636443 |
| 96 | protein localization to microtubule cytoskeleton (GO:0072698) | 2.48595038 |
| 97 | positive regulation of histone methylation (GO:0031062) | 2.48325153 |
| 98 | metaphase plate congression (GO:0051310) | 2.47402901 |
| 99 | regulation of centriole replication (GO:0046599) | 2.45951162 |
| 100 | histone exchange (GO:0043486) | 2.45883559 |
| 101 | positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) | 2.44497882 |
| 102 | mitotic metaphase plate congression (GO:0007080) | 2.42528136 |
| 103 | replication fork processing (GO:0031297) | 2.42438835 |
| 104 | sister chromatid segregation (GO:0000819) | 2.40535690 |
| 105 | protein K6-linked ubiquitination (GO:0085020) | 2.38481142 |
| 106 | developmental pigmentation (GO:0048066) | 2.38479471 |
| 107 | regulation of helicase activity (GO:0051095) | 2.38272934 |
| 108 | * regulation of mRNA splicing, via spliceosome (GO:0048024) | 2.37018279 |
| 109 | regulation of histone methylation (GO:0031060) | 2.36869182 |
| 110 | cell proliferation in forebrain (GO:0021846) | 2.36380420 |
| 111 | peptidyl-lysine methylation (GO:0018022) | 2.35583099 |
| 112 | regulation of DNA-dependent DNA replication (GO:0090329) | 2.34705148 |
| 113 | V(D)J recombination (GO:0033151) | 2.34444332 |
| 114 | mitotic sister chromatid segregation (GO:0000070) | 2.33572447 |
| 115 | interkinetic nuclear migration (GO:0022027) | 2.32305804 |
| 116 | replicative senescence (GO:0090399) | 2.31857915 |
| 117 | regulation of histone H3-K4 methylation (GO:0051569) | 2.30104089 |
| 118 | * regulation of mRNA metabolic process (GO:1903311) | 2.29685131 |
| 119 | positive regulation of mRNA processing (GO:0050685) | 2.27759308 |
| 120 | DNA methylation involved in gamete generation (GO:0043046) | 2.27633414 |
| 121 | limb bud formation (GO:0060174) | 2.27115247 |
| 122 | regulation of gene expression by genetic imprinting (GO:0006349) | 2.25207348 |
| 123 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.24505689 |
| 124 | mRNA export from nucleus (GO:0006406) | 2.23484884 |
| 125 | termination of RNA polymerase II transcription (GO:0006369) | 2.21906432 |
| 126 | microtubule polymerization or depolymerization (GO:0031109) | 2.21289805 |
| 127 | reciprocal meiotic recombination (GO:0007131) | 2.21077743 |
| 128 | reciprocal DNA recombination (GO:0035825) | 2.21077743 |
| 129 | DNA methylation or demethylation (GO:0044728) | 2.20834289 |
| 130 | histone methylation (GO:0016571) | 2.20729931 |
| 131 | spindle checkpoint (GO:0031577) | 2.19768171 |
| 132 | establishment of integrated proviral latency (GO:0075713) | 2.18898453 |
| 133 | histone H3-K36 demethylation (GO:0070544) | 2.18367165 |
| 134 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.16984739 |
| 135 | negative regulation of mRNA processing (GO:0050686) | 2.16539470 |
| 136 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.16323232 |
| 137 | microtubule anchoring (GO:0034453) | 2.15010483 |
| 138 | DNA synthesis involved in DNA repair (GO:0000731) | 2.14898649 |
| 139 | positive regulation of mRNA 3-end processing (GO:0031442) | 2.13083473 |
| 140 | ATP-dependent chromatin remodeling (GO:0043044) | 2.10786237 |
| 141 | mesenchymal cell differentiation involved in kidney development (GO:0072161) | 2.10612947 |
| 142 | mesenchymal cell differentiation involved in renal system development (GO:2001012) | 2.10612947 |
| 143 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.09660708 |
| 144 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.09624018 |
| 145 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.09624018 |
| 146 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.09624018 |
| 147 | DNA double-strand break processing (GO:0000729) | 2.09534804 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.04900304 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.24772042 |
| 3 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.85553041 |
| 4 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.61554479 |
| 5 | FUS_26573619_Chip-Seq_HEK293_Human | 2.61392543 |
| 6 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.56147865 |
| 7 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.54432912 |
| 8 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.50441135 |
| 9 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.49006214 |
| 10 | EWS_26573619_Chip-Seq_HEK293_Human | 2.39567238 |
| 11 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.38526556 |
| 12 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.37444116 |
| 13 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.31243239 |
| 14 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.30404598 |
| 15 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.28015743 |
| 16 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.27744864 |
| 17 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.25826138 |
| 18 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.24791608 |
| 19 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.21477562 |
| 20 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.18923509 |
| 21 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.10361226 |
| 22 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.07199512 |
| 23 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.04822926 |
| 24 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.91931958 |
| 25 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.91443683 |
| 26 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.84627735 |
| 27 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.72136713 |
| 28 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.70664058 |
| 29 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.68511987 |
| 30 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.66252646 |
| 31 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.65311220 |
| 32 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.64487107 |
| 33 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.63012192 |
| 34 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.62188919 |
| 35 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.61632700 |
| 36 | P300_19829295_ChIP-Seq_ESCs_Human | 1.61057110 |
| 37 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.57381588 |
| 38 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.55402735 |
| 39 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.53158471 |
| 40 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.52247266 |
| 41 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.52247266 |
| 42 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.51668126 |
| 43 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.51648233 |
| 44 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.49877930 |
| 45 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.49655611 |
| 46 | TP53_16413492_ChIP-PET_HCT116_Human | 1.46999657 |
| 47 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.44241041 |
| 48 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.44031779 |
| 49 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.43635543 |
| 50 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.43575643 |
| 51 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.40521709 |
| 52 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.38523697 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.38206647 |
| 54 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.37964619 |
| 55 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.37467668 |
| 56 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.36682423 |
| 57 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.34815228 |
| 58 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.34639180 |
| 59 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.32664404 |
| 60 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.32602352 |
| 61 | STAT3_23295773_ChIP-Seq_U87_Human | 1.32556194 |
| 62 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.31664201 |
| 63 | TCF4_23295773_ChIP-Seq_U87_Human | 1.31371851 |
| 64 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.30855475 |
| 65 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.30657354 |
| 66 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.30410352 |
| 67 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.30294070 |
| 68 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.28053897 |
| 69 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.27857230 |
| 70 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.27462722 |
| 71 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.26210955 |
| 72 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.26032444 |
| 73 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.25440574 |
| 74 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.25389268 |
| 75 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.24857473 |
| 76 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.24420840 |
| 77 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.23956270 |
| 78 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23414500 |
| 79 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.21502547 |
| 80 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.20788530 |
| 81 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.20332887 |
| 82 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.20200498 |
| 83 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.20129234 |
| 84 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.20129234 |
| 85 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.19220646 |
| 86 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.19019502 |
| 87 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.19019502 |
| 88 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.19019502 |
| 89 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.18578285 |
| 90 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.18305364 |
| 91 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.16935132 |
| 92 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.16817862 |
| 93 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.16736291 |
| 94 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.15155256 |
| 95 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 1.14399347 |
| 96 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.12728572 |
| 97 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 1.12093293 |
| 98 | * GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.11416248 |
| 99 | VDR_22108803_ChIP-Seq_LS180_Human | 1.08840821 |
| 100 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.08800784 |
| 101 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.07947354 |
| 102 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.07702579 |
| 103 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07341477 |
| 104 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.07272944 |
| 105 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.04505937 |
| 106 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.04391086 |
| 107 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 1.03746402 |
| 108 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.03206459 |
| 109 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.03159904 |
| 110 | PU1_27457419_Chip-Seq_LIVER_Mouse | 1.02884661 |
| 111 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.02766557 |
| 112 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 1.01993016 |
| 113 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.01472017 |
| 114 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.00886276 |
| 115 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00799198 |
| 116 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.00349965 |
| 117 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.99762169 |
| 118 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.99698982 |
| 119 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.98754029 |
| 120 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.98031172 |
| 121 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.97177475 |
| 122 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.95076106 |
| 123 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.94955815 |
| 124 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.94874595 |
| 125 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.94862730 |
| 126 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.93677314 |
| 127 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.93533222 |
| 128 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.92420583 |
| 129 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.92391370 |
| 130 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92273064 |
| 131 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92067598 |
| 132 | TBL1_22424771_ChIP-Seq_293T_Human | 0.91957628 |
| 133 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.90436340 |
| 134 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.90086474 |
| 135 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.89473754 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 3.74938276 |
| 2 | MP0003787_abnormal_imprinting | 3.40625280 |
| 3 | MP0006292_abnormal_olfactory_placode | 3.34062482 |
| 4 | MP0001188_hyperpigmentation | 3.19021944 |
| 5 | MP0000569_abnormal_digit_pigmentation | 3.12111503 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.93055860 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.88978032 |
| 8 | MP0005409_darkened_coat_color | 2.71802013 |
| 9 | MP0000566_synostosis | 2.65255705 |
| 10 | MP0003136_yellow_coat_color | 2.48729770 |
| 11 | MP0010094_abnormal_chromosome_stability | 2.48615600 |
| 12 | MP0008058_abnormal_DNA_repair | 2.34850517 |
| 13 | MP0003121_genomic_imprinting | 2.28494382 |
| 14 | MP0000015_abnormal_ear_pigmentation | 2.24967914 |
| 15 | MP0003111_abnormal_nucleus_morphology | 2.18332912 |
| 16 | MP0005174_abnormal_tail_pigmentation | 1.97438242 |
| 17 | MP0005171_absent_coat_pigmentation | 1.91177244 |
| 18 | MP0002102_abnormal_ear_morphology | 1.90211947 |
| 19 | MP0003941_abnormal_skin_development | 1.89380606 |
| 20 | MP0003077_abnormal_cell_cycle | 1.75316684 |
| 21 | MP0003880_abnormal_central_pattern | 1.71372232 |
| 22 | MP0004381_abnormal_hair_follicle | 1.55262918 |
| 23 | MP0002396_abnormal_hematopoietic_system | 1.48211632 |
| 24 | MP0008007_abnormal_cellular_replicative | 1.47988265 |
| 25 | MP0002277_abnormal_respiratory_mucosa | 1.42428685 |
| 26 | MP0003937_abnormal_limbs/digits/tail_de | 1.40982424 |
| 27 | MP0003123_paternal_imprinting | 1.38313106 |
| 28 | MP0000778_abnormal_nervous_system | 1.34452642 |
| 29 | MP0002938_white_spotting | 1.33242888 |
| 30 | MP0003950_abnormal_plasma_membrane | 1.31785316 |
| 31 | MP0002095_abnormal_skin_pigmentation | 1.30703579 |
| 32 | MP0003567_abnormal_fetal_cardiomyocyte | 1.25733097 |
| 33 | MP0003938_abnormal_ear_development | 1.25574025 |
| 34 | MP0002233_abnormal_nose_morphology | 1.25312547 |
| 35 | MP0004957_abnormal_blastocyst_morpholog | 1.23512353 |
| 36 | MP0008995_early_reproductive_senescence | 1.20155662 |
| 37 | MP0000383_abnormal_hair_follicle | 1.19056148 |
| 38 | MP0001697_abnormal_embryo_size | 1.18524529 |
| 39 | MP0009672_abnormal_birth_weight | 1.15346259 |
| 40 | MP0000428_abnormal_craniofacial_morphol | 1.14424111 |
| 41 | MP0001486_abnormal_startle_reflex | 1.14414805 |
| 42 | MP0004197_abnormal_fetal_growth/weight/ | 1.14254550 |
| 43 | MP0003119_abnormal_digestive_system | 1.13733420 |
| 44 | MP0008932_abnormal_embryonic_tissue | 1.13288181 |
| 45 | MP0005394_taste/olfaction_phenotype | 1.12255673 |
| 46 | MP0005499_abnormal_olfactory_system | 1.12255673 |
| 47 | MP0002163_abnormal_gland_morphology | 1.12250656 |
| 48 | MP0003890_abnormal_embryonic-extraembry | 1.11981131 |
| 49 | MP0004742_abnormal_vestibular_system | 1.10879152 |
| 50 | MP0008789_abnormal_olfactory_epithelium | 1.07330220 |
| 51 | MP0003786_premature_aging | 1.07220215 |
| 52 | MP0003755_abnormal_palate_morphology | 1.07211186 |
| 53 | MP0001286_abnormal_eye_development | 1.05967992 |
| 54 | MP0002210_abnormal_sex_determination | 1.05566793 |
| 55 | MP0005423_abnormal_somatic_nervous | 1.04211157 |
| 56 | MP0005075_abnormal_melanosome_morpholog | 1.04116667 |
| 57 | MP0000049_abnormal_middle_ear | 1.03229412 |
| 58 | MP0000427_abnormal_hair_cycle | 1.03145586 |
| 59 | MP0003984_embryonic_growth_retardation | 1.02948515 |
| 60 | MP0000631_abnormal_neuroendocrine_gland | 1.02763044 |
| 61 | MP0001293_anophthalmia | 1.02225888 |
| 62 | MP0002088_abnormal_embryonic_growth/wei | 1.02224865 |
| 63 | MP0001730_embryonic_growth_arrest | 1.02156296 |
| 64 | MP0002751_abnormal_autonomic_nervous | 1.00636018 |
| 65 | MP0006072_abnormal_retinal_apoptosis | 0.98865324 |
| 66 | MP0001986_abnormal_taste_sensitivity | 0.97606610 |
| 67 | MP0000432_abnormal_head_morphology | 0.96747257 |
| 68 | MP0002160_abnormal_reproductive_system | 0.95920507 |
| 69 | MP0005551_abnormal_eye_electrophysiolog | 0.95686394 |
| 70 | MP0000955_abnormal_spinal_cord | 0.94394500 |
| 71 | MP0002177_abnormal_outer_ear | 0.94303891 |
| 72 | MP0003943_abnormal_hepatobiliary_system | 0.93977609 |
| 73 | MP0002184_abnormal_innervation | 0.93261437 |
| 74 | MP0003861_abnormal_nervous_system | 0.91682994 |
| 75 | MP0002111_abnormal_tail_morphology | 0.89276940 |
| 76 | MP0001485_abnormal_pinna_reflex | 0.87546603 |
| 77 | MP0004808_abnormal_hematopoietic_stem | 0.87164417 |
| 78 | MP0000647_abnormal_sebaceous_gland | 0.87063063 |
| 79 | MP0002735_abnormal_chemical_nociception | 0.83953297 |
| 80 | MP0010307_abnormal_tumor_latency | 0.83342836 |
| 81 | MP0000026_abnormal_inner_ear | 0.82190132 |
| 82 | MP0005253_abnormal_eye_physiology | 0.80574565 |
| 83 | MP0001177_atelectasis | 0.80421587 |
| 84 | MP0003935_abnormal_craniofacial_develop | 0.80096521 |
| 85 | MP0003718_maternal_effect | 0.80093352 |
| 86 | MP0002653_abnormal_ependyma_morphology | 0.79947520 |
| 87 | MP0004133_heterotaxia | 0.79539087 |
| 88 | MP0005379_endocrine/exocrine_gland_phen | 0.79104209 |
| 89 | MP0010030_abnormal_orbit_morphology | 0.79101512 |
| 90 | MP0001963_abnormal_hearing_physiology | 0.78830203 |
| 91 | MP0003385_abnormal_body_wall | 0.78523258 |
| 92 | MP0005645_abnormal_hypothalamus_physiol | 0.78311554 |
| 93 | MP0002116_abnormal_craniofacial_bone | 0.77821923 |
| 94 | MP0002085_abnormal_embryonic_tissue | 0.77186871 |
| 95 | MP0001145_abnormal_male_reproductive | 0.77170836 |
| 96 | MP0002009_preneoplasia | 0.76917326 |
| 97 | MP0002075_abnormal_coat/hair_pigmentati | 0.76851478 |
| 98 | MP0002092_abnormal_eye_morphology | 0.76750621 |
| 99 | MP0003698_abnormal_male_reproductive | 0.76420546 |
| 100 | MP0005646_abnormal_pituitary_gland | 0.76223767 |
| 101 | MP0001929_abnormal_gametogenesis | 0.75881999 |
| 102 | MP0009250_abnormal_appendicular_skeleto | 0.75843120 |
| 103 | MP0009703_decreased_birth_body | 0.74923324 |
| 104 | MP0003315_abnormal_perineum_morphology | 0.74776111 |
| 105 | MP0002249_abnormal_larynx_morphology | 0.74716859 |
| 106 | MP0009046_muscle_twitch | 0.74670465 |
| 107 | MP0006276_abnormal_autonomic_nervous | 0.74517154 |
| 108 | MP0002080_prenatal_lethality | 0.73950789 |
| 109 | MP0009745_abnormal_behavioral_response | 0.73836700 |
| 110 | MP0004885_abnormal_endolymph | 0.73561113 |
| 111 | MP0002084_abnormal_developmental_patter | 0.73171269 |
| 112 | MP0000350_abnormal_cell_proliferation | 0.72087602 |
| 113 | MP0004142_abnormal_muscle_tone | 0.70958260 |
| 114 | MP0002557_abnormal_social/conspecific_i | 0.70684763 |
| 115 | MP0002752_abnormal_somatic_nervous | 0.70082763 |
| 116 | MP0002114_abnormal_axial_skeleton | 0.69851213 |
| 117 | MP0001186_pigmentation_phenotype | 0.69659161 |
| 118 | MP0009379_abnormal_foot_pigmentation | 0.69162837 |
| 119 | MP0001299_abnormal_eye_distance/ | 0.68289704 |
| 120 | MP0001529_abnormal_vocalization | 0.68225295 |
| 121 | MP0000653_abnormal_sex_gland | 0.67652733 |
| 122 | MP0001672_abnormal_embryogenesis/_devel | 0.66813637 |
| 123 | MP0005380_embryogenesis_phenotype | 0.66813637 |
| 124 | MP0000703_abnormal_thymus_morphology | 0.65962489 |
| 125 | MP0002109_abnormal_limb_morphology | 0.65873107 |
| 126 | MP0003122_maternal_imprinting | 0.64608884 |
| 127 | MP0002081_perinatal_lethality | 0.64074188 |
| 128 | MP0005391_vision/eye_phenotype | 0.63786523 |
| 129 | MP0003828_pulmonary_edema | 0.63235097 |
| 130 | MP0004147_increased_porphyrin_level | 0.62981684 |
| 131 | MP0002697_abnormal_eye_size | 0.62123750 |
| 132 | MP0005257_abnormal_intraocular_pressure | 0.62009065 |
| 133 | MP0002272_abnormal_nervous_system | 0.61761826 |
| 134 | MP0002152_abnormal_brain_morphology | 0.61730772 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 4.65661143 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.50271096 |
| 3 | Volvulus (HP:0002580) | 3.80622813 |
| 4 | Ectopic kidney (HP:0000086) | 3.02821358 |
| 5 | Duplicated collecting system (HP:0000081) | 2.95860728 |
| 6 | Abnormality of the columella (HP:0009929) | 2.94164737 |
| 7 | Abnormality of the renal collecting system (HP:0004742) | 2.80868412 |
| 8 | Abnormality of chromosome stability (HP:0003220) | 2.79131030 |
| 9 | Abnormality of the fingertips (HP:0001211) | 2.77357615 |
| 10 | Meckel diverticulum (HP:0002245) | 2.63015005 |
| 11 | Abnormality of the preputium (HP:0100587) | 2.62459907 |
| 12 | Colon cancer (HP:0003003) | 2.62139727 |
| 13 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.56080991 |
| 14 | Supernumerary ribs (HP:0005815) | 2.54539486 |
| 15 | Lip pit (HP:0100267) | 2.53429789 |
| 16 | Abnormality of the ileum (HP:0001549) | 2.53287373 |
| 17 | Birth length less than 3rd percentile (HP:0003561) | 2.53092997 |
| 18 | Oligodactyly (hands) (HP:0001180) | 2.52689184 |
| 19 | Abnormality of DNA repair (HP:0003254) | 2.49504618 |
| 20 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.49032634 |
| 21 | Abnormality of the nasal septum (HP:0000419) | 2.44410973 |
| 22 | Septo-optic dysplasia (HP:0100842) | 2.40744165 |
| 23 | Anal stenosis (HP:0002025) | 2.40487211 |
| 24 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.34662950 |
| 25 | Cupped ear (HP:0000378) | 2.34052183 |
| 26 | Chronic hepatic failure (HP:0100626) | 2.33854335 |
| 27 | Hepatoblastoma (HP:0002884) | 2.33753318 |
| 28 | Intestinal atresia (HP:0011100) | 2.32542369 |
| 29 | Supernumerary spleens (HP:0009799) | 2.24389800 |
| 30 | Absent radius (HP:0003974) | 2.22670245 |
| 31 | Abnormality of the labia minora (HP:0012880) | 2.21705535 |
| 32 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.20144716 |
| 33 | Absent forearm bone (HP:0003953) | 2.17391693 |
| 34 | Aplasia involving forearm bones (HP:0009822) | 2.17391693 |
| 35 | Protruding tongue (HP:0010808) | 2.16856589 |
| 36 | Genetic anticipation (HP:0003743) | 2.16375579 |
| 37 | Embryonal renal neoplasm (HP:0011794) | 2.16174395 |
| 38 | Aplasia cutis congenita (HP:0001057) | 2.16111548 |
| 39 | Rib fusion (HP:0000902) | 2.11019151 |
| 40 | Tubulointerstitial nephritis (HP:0001970) | 2.10306313 |
| 41 | Increased nuchal translucency (HP:0010880) | 2.09634735 |
| 42 | Abnormality of midbrain morphology (HP:0002418) | 2.09394034 |
| 43 | Molar tooth sign on MRI (HP:0002419) | 2.09394034 |
| 44 | Clubbing of toes (HP:0100760) | 2.08698922 |
| 45 | Abnormality of the incisor (HP:0000676) | 2.05759142 |
| 46 | Papillary thyroid carcinoma (HP:0002895) | 2.05189363 |
| 47 | Bilateral microphthalmos (HP:0007633) | 2.04001731 |
| 48 | Pancreatic fibrosis (HP:0100732) | 2.02028522 |
| 49 | Acute myeloid leukemia (HP:0004808) | 2.01858702 |
| 50 | Esophageal atresia (HP:0002032) | 1.98206191 |
| 51 | Preaxial hand polydactyly (HP:0001177) | 1.97504240 |
| 52 | Prostate neoplasm (HP:0100787) | 1.97487385 |
| 53 | Gastroesophageal reflux (HP:0002020) | 1.95302120 |
| 54 | Drooling (HP:0002307) | 1.95051576 |
| 55 | Aqueductal stenosis (HP:0002410) | 1.94543699 |
| 56 | Rhabdomyosarcoma (HP:0002859) | 1.94340439 |
| 57 | Gastrointestinal atresia (HP:0002589) | 1.92904622 |
| 58 | Abnormal number of incisors (HP:0011064) | 1.92423739 |
| 59 | True hermaphroditism (HP:0010459) | 1.91957681 |
| 60 | Midline defect of the nose (HP:0004122) | 1.89782230 |
| 61 | Microtia (HP:0008551) | 1.89433249 |
| 62 | Oligodactyly (HP:0012165) | 1.88415339 |
| 63 | Truncal obesity (HP:0001956) | 1.88112819 |
| 64 | Duodenal stenosis (HP:0100867) | 1.86442248 |
| 65 | Small intestinal stenosis (HP:0012848) | 1.86442248 |
| 66 | Narrow forehead (HP:0000341) | 1.85665657 |
| 67 | Abnormal hair whorl (HP:0010721) | 1.83492127 |
| 68 | Abnormality of the septum pellucidum (HP:0007375) | 1.83388295 |
| 69 | Bifid tongue (HP:0010297) | 1.82376390 |
| 70 | Capillary hemangiomas (HP:0005306) | 1.82293535 |
| 71 | Abnormality of the carotid arteries (HP:0005344) | 1.81818988 |
| 72 | Hyperventilation (HP:0002883) | 1.81357533 |
| 73 | Patellar aplasia (HP:0006443) | 1.81042515 |
| 74 | Myelodysplasia (HP:0002863) | 1.80952247 |
| 75 | Abnormality of incisor morphology (HP:0011063) | 1.80814828 |
| 76 | Abnormality of the antihelix (HP:0009738) | 1.80665307 |
| 77 | Pancreatic cysts (HP:0001737) | 1.78703754 |
| 78 | Long eyelashes (HP:0000527) | 1.78569055 |
| 79 | Abnormality of the parietal bone (HP:0002696) | 1.78455738 |
| 80 | Cystic liver disease (HP:0006706) | 1.78175888 |
| 81 | Hypoplasia of the pons (HP:0012110) | 1.77686421 |
| 82 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.77588656 |
| 83 | Dandy-Walker malformation (HP:0001305) | 1.77442533 |
| 84 | Chin dimple (HP:0010751) | 1.77441574 |
| 85 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.77054205 |
| 86 | Postaxial foot polydactyly (HP:0001830) | 1.76511075 |
| 87 | Nephronophthisis (HP:0000090) | 1.76436246 |
| 88 | Abnormality of the renal medulla (HP:0100957) | 1.76296588 |
| 89 | Reticulocytopenia (HP:0001896) | 1.76196218 |
| 90 | Hypoplastic labia majora (HP:0000059) | 1.76078638 |
| 91 | White forelock (HP:0002211) | 1.75972664 |
| 92 | Exotropia (HP:0000577) | 1.75737064 |
| 93 | Abnormality of the pons (HP:0007361) | 1.75287251 |
| 94 | Excessive salivation (HP:0003781) | 1.75119523 |
| 95 | Renal agenesis (HP:0000104) | 1.74468684 |
| 96 | Bile duct proliferation (HP:0001408) | 1.74253235 |
| 97 | Abnormal biliary tract physiology (HP:0012439) | 1.74253235 |
| 98 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.74207572 |
| 99 | Medial flaring of the eyebrow (HP:0010747) | 1.73768565 |
| 100 | Anophthalmia (HP:0000528) | 1.73305496 |
| 101 | Genital tract atresia (HP:0001827) | 1.73091520 |
| 102 | Impulsivity (HP:0100710) | 1.72704846 |
| 103 | Febrile seizures (HP:0002373) | 1.72522646 |
| 104 | Triphalangeal thumb (HP:0001199) | 1.71904822 |
| 105 | 2-3 toe syndactyly (HP:0004691) | 1.71880213 |
| 106 | Neoplasm of striated muscle (HP:0009728) | 1.71436454 |
| 107 | Abnormal lung lobation (HP:0002101) | 1.71065020 |
| 108 | Fair hair (HP:0002286) | 1.70569073 |
| 109 | Duplication of thumb phalanx (HP:0009942) | 1.69708590 |
| 110 | Absent speech (HP:0001344) | 1.69424710 |
| 111 | Renal hypoplasia (HP:0000089) | 1.69212797 |
| 112 | Neoplasm of the oral cavity (HP:0100649) | 1.69104360 |
| 113 | Abnormality of the aortic arch (HP:0012303) | 1.68521019 |
| 114 | Inappropriate behavior (HP:0000719) | 1.68408204 |
| 115 | Poor coordination (HP:0002370) | 1.67921445 |
| 116 | Abnormality of the duodenum (HP:0002246) | 1.67664127 |
| 117 | Medulloblastoma (HP:0002885) | 1.67605546 |
| 118 | Absent septum pellucidum (HP:0001331) | 1.66913415 |
| 119 | Broad-based gait (HP:0002136) | 1.66896108 |
| 120 | Anencephaly (HP:0002323) | 1.66440571 |
| 121 | Vaginal atresia (HP:0000148) | 1.66099762 |
| 122 | Abnormality of cochlea (HP:0000375) | 1.65303136 |
| 123 | Holoprosencephaly (HP:0001360) | 1.63562849 |
| 124 | Acute lymphatic leukemia (HP:0006721) | 1.62604017 |
| 125 | Asplenia (HP:0001746) | 1.62212257 |
| 126 | Urethral obstruction (HP:0000796) | 1.61793795 |
| 127 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.61383044 |
| 128 | Short thumb (HP:0009778) | 1.60639795 |
| 129 | Bone marrow hypocellularity (HP:0005528) | 1.60118564 |
| 130 | Widely spaced teeth (HP:0000687) | 1.58607339 |
| 131 | Chorioretinal coloboma (HP:0000567) | 1.57744612 |
| 132 | Sloping forehead (HP:0000340) | 1.57689165 |
| 133 | Deep philtrum (HP:0002002) | 1.57104409 |
| 134 | Overfolded helix (HP:0000396) | 1.56756148 |
| 135 | Median cleft lip (HP:0000161) | 1.55162261 |
| 136 | Abdominal situs inversus (HP:0003363) | 1.55057655 |
| 137 | Abnormality of abdominal situs (HP:0011620) | 1.55057655 |
| 138 | Optic nerve hypoplasia (HP:0000609) | 1.53929093 |
| 139 | Highly arched eyebrow (HP:0002553) | 1.52528259 |
| 140 | Anal atresia (HP:0002023) | 1.52213559 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BRD4 | 3.64331653 |
| 2 | CDC7 | 3.24074533 |
| 3 | MKNK2 | 3.24017279 |
| 4 | CASK | 3.01280202 |
| 5 | CDK12 | 2.67199252 |
| 6 | SRPK1 | 2.47032438 |
| 7 | MKNK1 | 2.44512686 |
| 8 | TNIK | 2.32194865 |
| 9 | PNCK | 2.27054936 |
| 10 | WNK3 | 2.25754815 |
| 11 | PRPF4B | 2.16586155 |
| 12 | NUAK1 | 2.06536026 |
| 13 | TAF1 | 1.94209582 |
| 14 | CDK3 | 1.93455703 |
| 15 | EPHA3 | 1.92324334 |
| 16 | BRSK2 | 1.71088174 |
| 17 | MAP3K4 | 1.67046439 |
| 18 | PLK4 | 1.63271011 |
| 19 | AKT3 | 1.55848566 |
| 20 | MAP4K2 | 1.55799428 |
| 21 | FRK | 1.54959388 |
| 22 | ZAK | 1.54504052 |
| 23 | FGFR2 | 1.50216613 |
| 24 | TTK | 1.37624355 |
| 25 | ACVR1B | 1.37593532 |
| 26 | EIF2AK2 | 1.35071565 |
| 27 | NEK6 | 1.30250937 |
| 28 | IRAK4 | 1.29915446 |
| 29 | LATS1 | 1.28407243 |
| 30 | CDK8 | 1.27655284 |
| 31 | TXK | 1.27492400 |
| 32 | INSRR | 1.25757648 |
| 33 | ATR | 1.25168323 |
| 34 | YES1 | 1.25131872 |
| 35 | CLK1 | 1.24468630 |
| 36 | MARK1 | 1.24387452 |
| 37 | CHEK2 | 1.24359692 |
| 38 | IRAK3 | 1.22938603 |
| 39 | NME1 | 1.18228714 |
| 40 | MAP3K10 | 1.14488736 |
| 41 | SIK2 | 1.12668748 |
| 42 | MAPK13 | 1.11793229 |
| 43 | PLK3 | 1.09495385 |
| 44 | BMPR1B | 1.06351781 |
| 45 | STK38L | 1.05982400 |
| 46 | STK16 | 1.05939218 |
| 47 | CHEK1 | 1.03790288 |
| 48 | ATM | 1.02935094 |
| 49 | BUB1 | 1.01971480 |
| 50 | PLK2 | 0.94682254 |
| 51 | CDK7 | 0.92982872 |
| 52 | PAK3 | 0.92881278 |
| 53 | TRPM7 | 0.91934304 |
| 54 | PKN1 | 0.91777251 |
| 55 | PASK | 0.90875671 |
| 56 | EPHA4 | 0.89462433 |
| 57 | PLK1 | 0.87355844 |
| 58 | VRK1 | 0.86437564 |
| 59 | DMPK | 0.86268238 |
| 60 | TYRO3 | 0.85691753 |
| 61 | DYRK3 | 0.84787956 |
| 62 | FGFR1 | 0.84518228 |
| 63 | WNK4 | 0.83495051 |
| 64 | BLK | 0.83257670 |
| 65 | CAMK1G | 0.83218004 |
| 66 | ALK | 0.82217844 |
| 67 | WNK1 | 0.81917431 |
| 68 | NLK | 0.81319180 |
| 69 | MAP2K7 | 0.81261466 |
| 70 | SIK3 | 0.80208389 |
| 71 | TSSK6 | 0.78865755 |
| 72 | DYRK2 | 0.78725346 |
| 73 | MAP3K14 | 0.77699490 |
| 74 | WEE1 | 0.76651347 |
| 75 | BMPR2 | 0.75978957 |
| 76 | CDK9 | 0.75276259 |
| 77 | AURKB | 0.74937639 |
| 78 | MELK | 0.73928400 |
| 79 | TAOK2 | 0.72407476 |
| 80 | RPS6KA5 | 0.72103909 |
| 81 | CDK1 | 0.71843599 |
| 82 | GRK7 | 0.71239264 |
| 83 | SGK2 | 0.69963574 |
| 84 | PRKD2 | 0.69955988 |
| 85 | STK4 | 0.69231366 |
| 86 | ADRBK2 | 0.67368416 |
| 87 | CDK2 | 0.66899144 |
| 88 | RIPK4 | 0.66632335 |
| 89 | PRKCG | 0.66271374 |
| 90 | STK39 | 0.65897004 |
| 91 | GRK1 | 0.65066354 |
| 92 | CSNK1E | 0.63432054 |
| 93 | EIF2AK3 | 0.62158950 |
| 94 | SGK1 | 0.61792049 |
| 95 | MAPK14 | 0.61604034 |
| 96 | CSNK1A1L | 0.59929673 |
| 97 | PIK3CA | 0.59523806 |
| 98 | MST4 | 0.57006099 |
| 99 | IRAK1 | 0.56934934 |
| 100 | MAPK10 | 0.56844612 |
| 101 | GSK3B | 0.56766249 |
| 102 | NTRK3 | 0.54897930 |
| 103 | CDK4 | 0.54403748 |
| 104 | PRKDC | 0.54232939 |
| 105 | NEK2 | 0.53631628 |
| 106 | BCR | 0.52881715 |
| 107 | TEC | 0.52444150 |
| 108 | MAPK15 | 0.52316960 |
| 109 | PBK | 0.49704483 |
| 110 | DYRK1A | 0.49544247 |
| 111 | CSNK2A2 | 0.48901416 |
| 112 | STK3 | 0.48698756 |
| 113 | BRSK1 | 0.47908972 |
| 114 | TGFBR1 | 0.47472274 |
| 115 | CSNK1D | 0.47408671 |
| 116 | MARK2 | 0.47104899 |
| 117 | STK11 | 0.45416584 |
| 118 | LYN | 0.44539519 |
| 119 | RPS6KB2 | 0.44044672 |
| 120 | CDC42BPA | 0.43403959 |
| 121 | OXSR1 | 0.43151203 |
| 122 | PRKG1 | 0.42358304 |
| 123 | PRKCQ | 0.42205363 |
| 124 | MARK3 | 0.42187538 |
| 125 | UHMK1 | 0.41264780 |
| 126 | MAPK7 | 0.41256123 |
| 127 | AKT1 | 0.39965374 |
| 128 | STK24 | 0.39730248 |
| 129 | MAPK8 | 0.39585906 |
| 130 | CAMK1D | 0.39288111 |
| 131 | PRKACB | 0.39253500 |
| 132 | FES | 0.39229917 |
| 133 | NTRK2 | 0.38664464 |
| 134 | TLK1 | 0.38333819 |
| 135 | SGK223 | 0.36599924 |
| 136 | CAMKK2 | 0.36461411 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.93908088 |
| 2 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.59925779 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 2.42706954 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.35388307 |
| 5 | Basal transcription factors_Homo sapiens_hsa03022 | 2.32490855 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.31431920 |
| 7 | * Spliceosome_Homo sapiens_hsa03040 | 2.15665772 |
| 8 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.11149134 |
| 9 | Protein export_Homo sapiens_hsa03060 | 1.95800319 |
| 10 | Nicotine addiction_Homo sapiens_hsa05033 | 1.92482637 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 1.89260953 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 1.75789248 |
| 13 | Cell cycle_Homo sapiens_hsa04110 | 1.73320762 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 1.72949973 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 1.62368057 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 1.61765261 |
| 17 | Phototransduction_Homo sapiens_hsa04744 | 1.61480434 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.53604710 |
| 19 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42888844 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.39291559 |
| 21 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.27410754 |
| 22 | Base excision repair_Homo sapiens_hsa03410 | 1.25194657 |
| 23 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.21751056 |
| 24 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.20782557 |
| 25 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.20395876 |
| 26 | Taste transduction_Homo sapiens_hsa04742 | 1.18414607 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.17170105 |
| 28 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.14507331 |
| 29 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.11649275 |
| 30 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.11615999 |
| 31 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.08259260 |
| 32 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.07880469 |
| 33 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.06316420 |
| 34 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.06121391 |
| 35 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.04763773 |
| 36 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.99748186 |
| 37 | Morphine addiction_Homo sapiens_hsa05032 | 0.99239971 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.96342309 |
| 39 | Long-term potentiation_Homo sapiens_hsa04720 | 0.95652668 |
| 40 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.93717432 |
| 41 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.90890667 |
| 42 | Lysine degradation_Homo sapiens_hsa00310 | 0.87877892 |
| 43 | Long-term depression_Homo sapiens_hsa04730 | 0.87293919 |
| 44 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.86752712 |
| 45 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.85216644 |
| 46 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.84747141 |
| 47 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.84364319 |
| 48 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.84329506 |
| 49 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.81490666 |
| 50 | Measles_Homo sapiens_hsa05162 | 0.79703870 |
| 51 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.79550569 |
| 52 | Cocaine addiction_Homo sapiens_hsa05030 | 0.78994149 |
| 53 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.78792075 |
| 54 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.77413787 |
| 55 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.75841776 |
| 56 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.75414621 |
| 57 | Melanoma_Homo sapiens_hsa05218 | 0.75382023 |
| 58 | Prostate cancer_Homo sapiens_hsa05215 | 0.75154482 |
| 59 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.74778836 |
| 60 | Allograft rejection_Homo sapiens_hsa05330 | 0.74374992 |
| 61 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.73509264 |
| 62 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.73500244 |
| 63 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.72918789 |
| 64 | Adherens junction_Homo sapiens_hsa04520 | 0.72565343 |
| 65 | Huntingtons disease_Homo sapiens_hsa05016 | 0.72426801 |
| 66 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.72394244 |
| 67 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.70780643 |
| 68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.70778732 |
| 69 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.70591348 |
| 70 | HTLV-I infection_Homo sapiens_hsa05166 | 0.70239254 |
| 71 | Renin secretion_Homo sapiens_hsa04924 | 0.70048665 |
| 72 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.69164105 |
| 73 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.68273491 |
| 74 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.67184211 |
| 75 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.65392840 |
| 76 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.64727114 |
| 77 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.64459037 |
| 78 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.63700455 |
| 79 | Purine metabolism_Homo sapiens_hsa00230 | 0.63336205 |
| 80 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.62725424 |
| 81 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.62206515 |
| 82 | Circadian entrainment_Homo sapiens_hsa04713 | 0.61692992 |
| 83 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.61543842 |
| 84 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.60805911 |
| 85 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.60370261 |
| 86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.60307857 |
| 87 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.58941264 |
| 88 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.58582790 |
| 89 | Pathways in cancer_Homo sapiens_hsa05200 | 0.56610384 |
| 90 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.56592869 |
| 91 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56573847 |
| 92 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.55361216 |
| 93 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.54647834 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53875840 |
| 95 | Circadian rhythm_Homo sapiens_hsa04710 | 0.53872794 |
| 96 | Asthma_Homo sapiens_hsa05310 | 0.53807230 |
| 97 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.53789734 |
| 98 | Salivary secretion_Homo sapiens_hsa04970 | 0.53667905 |
| 99 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.53259222 |
| 100 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.53062183 |
| 101 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.52676441 |
| 102 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.52013907 |
| 103 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.51409279 |
| 104 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50751796 |
| 105 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.50720131 |
| 106 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.50600547 |
| 107 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.50456337 |
| 108 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.50389502 |
| 109 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.49968529 |
| 110 | Insulin secretion_Homo sapiens_hsa04911 | 0.49184643 |
| 111 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.48339347 |
| 112 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.47371031 |
| 113 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.47162765 |
| 114 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.46902165 |
| 115 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45980451 |
| 116 | Tight junction_Homo sapiens_hsa04530 | 0.45606305 |
| 117 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.44985848 |
| 118 | Melanogenesis_Homo sapiens_hsa04916 | 0.44900705 |
| 119 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.44386553 |
| 120 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.44238702 |
| 121 | Thyroid cancer_Homo sapiens_hsa05216 | 0.43995976 |
| 122 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.43732616 |
| 123 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.43249212 |
| 124 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.42565652 |
| 125 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.41205590 |
| 126 | Colorectal cancer_Homo sapiens_hsa05210 | 0.41197590 |
| 127 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.41154325 |
| 128 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.40753005 |
| 129 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.39997036 |
| 130 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.38844575 |
| 131 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35372894 |
| 132 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.34221680 |
| 133 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.33663665 |
| 134 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.32557022 |
| 135 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.32452218 |
| 136 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.31934191 |
| 137 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.30336257 |
| 138 | Endometrial cancer_Homo sapiens_hsa05213 | 0.29415350 |

