

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 5.20608888 |
| 2 | mitotic sister chromatid cohesion (GO:0007064) | 5.04939634 |
| 3 | nuclear pore organization (GO:0006999) | 4.62702397 |
| 4 | kinetochore organization (GO:0051383) | 4.26695528 |
| 5 | pore complex assembly (GO:0046931) | 4.13256294 |
| 6 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 4.10226885 |
| 7 | histone H3-K4 trimethylation (GO:0080182) | 4.08253911 |
| 8 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 4.05573031 |
| 9 | regulation of DNA endoreduplication (GO:0032875) | 3.92666654 |
| 10 | positive regulation of histone H3-K4 methylation (GO:0051571) | 3.75597698 |
| 11 | kinetochore assembly (GO:0051382) | 3.62513636 |
| 12 | peptidyl-lysine trimethylation (GO:0018023) | 3.60690977 |
| 13 | DNA replication checkpoint (GO:0000076) | 3.58920217 |
| 14 | V(D)J recombination (GO:0033151) | 3.48345420 |
| 15 | meiotic chromosome segregation (GO:0045132) | 3.47110527 |
| 16 | regulation of histone H3-K27 methylation (GO:0061085) | 3.42032005 |
| 17 | negative regulation of mRNA processing (GO:0050686) | 3.37379824 |
| 18 | regulation of helicase activity (GO:0051095) | 3.37093269 |
| 19 | sister chromatid cohesion (GO:0007062) | 3.35403751 |
| 20 | histone H3-K4 methylation (GO:0051568) | 3.35039434 |
| 21 | pre-miRNA processing (GO:0031054) | 3.31839499 |
| 22 | non-recombinational repair (GO:0000726) | 3.29630760 |
| 23 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.29630760 |
| 24 | rRNA catabolic process (GO:0016075) | 3.28367640 |
| 25 | histone H3-K9 methylation (GO:0051567) | 3.28111023 |
| 26 | mRNA splice site selection (GO:0006376) | 3.26895844 |
| 27 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.26266435 |
| 28 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.22339841 |
| 29 | ncRNA catabolic process (GO:0034661) | 3.21907558 |
| 30 | negative regulation of mRNA metabolic process (GO:1903312) | 3.19947916 |
| 31 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.19474498 |
| 32 | DNA unwinding involved in DNA replication (GO:0006268) | 3.15608672 |
| 33 | negative regulation of RNA splicing (GO:0033119) | 3.14263254 |
| 34 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.11441079 |
| 35 | regulation of centrosome cycle (GO:0046605) | 3.07236861 |
| 36 | CENP-A containing nucleosome assembly (GO:0034080) | 3.06937753 |
| 37 | DNA topological change (GO:0006265) | 3.06279066 |
| 38 | chromatin remodeling at centromere (GO:0031055) | 3.05568690 |
| 39 | regulation of histone H3-K9 methylation (GO:0051570) | 3.05470250 |
| 40 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.03065910 |
| 41 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.03065910 |
| 42 | negative regulation of histone methylation (GO:0031061) | 3.02761479 |
| 43 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 3.02660086 |
| 44 | somatic cell DNA recombination (GO:0016444) | 3.02660086 |
| 45 | DNA strand renaturation (GO:0000733) | 2.98416681 |
| 46 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.97415429 |
| 47 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.97415429 |
| 48 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.97415429 |
| 49 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.96504784 |
| 50 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.96504784 |
| 51 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.96504784 |
| 52 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.95642196 |
| 53 | replication fork processing (GO:0031297) | 2.94554740 |
| 54 | DNA double-strand break processing (GO:0000729) | 2.94196446 |
| 55 | protein localization to kinetochore (GO:0034501) | 2.94081162 |
| 56 | postreplication repair (GO:0006301) | 2.93359437 |
| 57 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.90931619 |
| 58 | histone lysine methylation (GO:0034968) | 2.87560798 |
| 59 | somatic diversification of immune receptors (GO:0002200) | 2.86776460 |
| 60 | regulation of telomere maintenance (GO:0032204) | 2.86206590 |
| 61 | paraxial mesoderm development (GO:0048339) | 2.85895865 |
| 62 | telomere maintenance via telomerase (GO:0007004) | 2.85573030 |
| 63 | protein localization to chromosome, centromeric region (GO:0071459) | 2.84372523 |
| 64 | regulation of DNA damage checkpoint (GO:2000001) | 2.83635468 |
| 65 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.82522514 |
| 66 | DNA replication-independent nucleosome organization (GO:0034724) | 2.82522514 |
| 67 | mitotic metaphase plate congression (GO:0007080) | 2.81924493 |
| 68 | regulation of histone H3-K4 methylation (GO:0051569) | 2.81888014 |
| 69 | metaphase plate congression (GO:0051310) | 2.81045642 |
| 70 | regulation of centriole replication (GO:0046599) | 2.80704350 |
| 71 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.79691330 |
| 72 | sister chromatid segregation (GO:0000819) | 2.79049850 |
| 73 | N-terminal protein amino acid acetylation (GO:0006474) | 2.78952503 |
| 74 | RNA-dependent DNA replication (GO:0006278) | 2.78440815 |
| 75 | histone H3-K9 modification (GO:0061647) | 2.78185342 |
| 76 | centriole replication (GO:0007099) | 2.77569651 |
| 77 | neural tube formation (GO:0001841) | 2.77369777 |
| 78 | translesion synthesis (GO:0019985) | 2.73371460 |
| 79 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.73060219 |
| 80 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.73060219 |
| 81 | establishment of chromosome localization (GO:0051303) | 2.72745307 |
| 82 | intra-S DNA damage checkpoint (GO:0031573) | 2.72110372 |
| 83 | histone H3-K36 demethylation (GO:0070544) | 2.71876122 |
| 84 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.71803582 |
| 85 | centriole assembly (GO:0098534) | 2.71490615 |
| 86 | DNA synthesis involved in DNA repair (GO:0000731) | 2.70917993 |
| 87 | somatic diversification of immunoglobulins (GO:0016445) | 2.70292191 |
| 88 | DNA geometric change (GO:0032392) | 2.70043816 |
| 89 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.69319376 |
| 90 | DNA duplex unwinding (GO:0032508) | 2.68668241 |
| 91 | double-strand break repair via homologous recombination (GO:0000724) | 2.68075046 |
| 92 | mitotic chromosome condensation (GO:0007076) | 2.67831717 |
| 93 | synapsis (GO:0007129) | 2.67733393 |
| 94 | regulation of DNA-dependent DNA replication (GO:0090329) | 2.67415667 |
| 95 | DNA-dependent DNA replication (GO:0006261) | 2.66441127 |
| 96 | peptidyl-lysine methylation (GO:0018022) | 2.66280197 |
| 97 | recombinational repair (GO:0000725) | 2.65259175 |
| 98 | positive regulation of chromosome segregation (GO:0051984) | 2.65091065 |
| 99 | single strand break repair (GO:0000012) | 2.65058034 |
| 100 | regulation of sister chromatid cohesion (GO:0007063) | 2.64788889 |
| 101 | nuclear envelope disassembly (GO:0051081) | 2.64623320 |
| 102 | membrane disassembly (GO:0030397) | 2.64623320 |
| 103 | positive regulation of mRNA catabolic process (GO:0061014) | 2.64311887 |
| 104 | nucleus organization (GO:0006997) | 2.63650571 |
| 105 | regulation of mRNA splicing, via spliceosome (GO:0048024) | 2.63099572 |
| 106 | microtubule anchoring (GO:0034453) | 2.62746664 |
| 107 | prenylation (GO:0097354) | 2.61316532 |
| 108 | protein prenylation (GO:0018342) | 2.61316532 |
| 109 | histone exchange (GO:0043486) | 2.61251276 |
| 110 | replicative senescence (GO:0090399) | 2.60719962 |
| 111 | regulation of RNA export from nucleus (GO:0046831) | 2.59427639 |
| 112 | negative regulation of DNA repair (GO:0045738) | 2.59367089 |
| 113 | protein K6-linked ubiquitination (GO:0085020) | 2.59111624 |
| 114 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.57733305 |
| 115 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.56823921 |
| 116 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.56823921 |
| 117 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.56356633 |
| 118 | ATP-dependent chromatin remodeling (GO:0043044) | 2.55249750 |
| 119 | mitotic nuclear envelope disassembly (GO:0007077) | 2.55124037 |
| 120 | negative regulation of DNA recombination (GO:0045910) | 2.54221526 |
| 121 | interkinetic nuclear migration (GO:0022027) | 2.52348207 |
| 122 | mitotic sister chromatid segregation (GO:0000070) | 2.51565952 |
| 123 | histone methylation (GO:0016571) | 2.51345278 |
| 124 | regulation of chromatin silencing (GO:0031935) | 2.50834722 |
| 125 | regulation of centrosome duplication (GO:0010824) | 2.49911951 |
| 126 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.49678108 |
| 127 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.48720618 |
| 128 | spindle checkpoint (GO:0031577) | 2.47804501 |
| 129 | negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147) | 2.47685614 |
| 130 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.47516468 |
| 131 | histone H2A acetylation (GO:0043968) | 2.47015536 |
| 132 | regulation of spindle organization (GO:0090224) | 2.46748416 |
| 133 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.46336425 |
| 134 | mismatch repair (GO:0006298) | 2.45975722 |
| 135 | mRNA export from nucleus (GO:0006406) | 2.45683967 |
| 136 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.45450775 |
| 137 | regulation of histone methylation (GO:0031060) | 2.45319270 |
| 138 | histone mRNA catabolic process (GO:0071044) | 2.43979032 |
| 139 | mRNA transport (GO:0051028) | 2.43796025 |
| 140 | histone H4-K12 acetylation (GO:0043983) | 2.41989654 |
| 141 | DNA conformation change (GO:0071103) | 2.40680178 |
| 142 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.40596917 |
| 143 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.40596917 |
| 144 | regulation of sister chromatid segregation (GO:0033045) | 2.40596917 |
| 145 | dosage compensation (GO:0007549) | 2.40571942 |
| 146 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.40314849 |
| 147 | regulation of gene expression by genetic imprinting (GO:0006349) | 2.39919456 |
| 148 | positive regulation of histone methylation (GO:0031062) | 2.39726580 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.41127471 |
| 2 | * SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.69139088 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.65969039 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.60574545 |
| 5 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.45972836 |
| 6 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.41606150 |
| 7 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 3.36603426 |
| 8 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.27398857 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.61469748 |
| 10 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.38904596 |
| 11 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.33703528 |
| 12 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.22934139 |
| 13 | FUS_26573619_Chip-Seq_HEK293_Human | 2.22353162 |
| 14 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.15994807 |
| 15 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.12026717 |
| 16 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.11361234 |
| 17 | * EWS_26573619_Chip-Seq_HEK293_Human | 2.11314744 |
| 18 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.05212816 |
| 19 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.03531010 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.01489887 |
| 21 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.89985494 |
| 22 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.87493234 |
| 23 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.85860894 |
| 24 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.85279419 |
| 25 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.80452718 |
| 26 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.74441943 |
| 27 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.72148882 |
| 28 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.66174311 |
| 29 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.65544159 |
| 30 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.62914439 |
| 31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.60770981 |
| 32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.52417339 |
| 33 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.47110425 |
| 34 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.44971174 |
| 35 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.44479636 |
| 36 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.42329996 |
| 37 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.41175577 |
| 38 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.34157140 |
| 39 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.28743455 |
| 40 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.28371187 |
| 41 | * FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.27289777 |
| 42 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.26791917 |
| 43 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.25037297 |
| 44 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.24887528 |
| 45 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.24460156 |
| 46 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.23987744 |
| 47 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23579312 |
| 48 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.22228722 |
| 49 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.21790578 |
| 50 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.21618196 |
| 51 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.20462526 |
| 52 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.19757931 |
| 53 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.18743844 |
| 54 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.18420522 |
| 55 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.17864931 |
| 56 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17537994 |
| 57 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.13328155 |
| 58 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.12876877 |
| 59 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.12858461 |
| 60 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.12858461 |
| 61 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.12858461 |
| 62 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.12195823 |
| 63 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.12195823 |
| 64 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.11999838 |
| 65 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.10837462 |
| 66 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.10220581 |
| 67 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.09945274 |
| 68 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.09472119 |
| 69 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.08924190 |
| 70 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.07503796 |
| 71 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.06335521 |
| 72 | VDR_22108803_ChIP-Seq_LS180_Human | 1.06099200 |
| 73 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.05358254 |
| 74 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.05348748 |
| 75 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.05126755 |
| 76 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.04753479 |
| 77 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04753479 |
| 78 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.04549488 |
| 79 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.03847910 |
| 80 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.02883590 |
| 81 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.02702579 |
| 82 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.02563251 |
| 83 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.02528983 |
| 84 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.02526144 |
| 85 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.01766133 |
| 86 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.01541765 |
| 87 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.01112808 |
| 88 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.00698561 |
| 89 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.00660520 |
| 90 | STAT3_23295773_ChIP-Seq_U87_Human | 1.00083751 |
| 91 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.98478926 |
| 92 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.98224699 |
| 93 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.98106082 |
| 94 | TCF4_23295773_ChIP-Seq_U87_Human | 0.97784273 |
| 95 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.96488484 |
| 96 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.96192075 |
| 97 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.95954711 |
| 98 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.95805144 |
| 99 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.95772531 |
| 100 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.95430715 |
| 101 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.95333310 |
| 102 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.95266055 |
| 103 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.95172768 |
| 104 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.95162564 |
| 105 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.95133685 |
| 106 | * TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.94451254 |
| 107 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.93693440 |
| 108 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.93308880 |
| 109 | TP53_16413492_ChIP-PET_HCT116_Human | 0.93022315 |
| 110 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.92314458 |
| 111 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.92163703 |
| 112 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.91892502 |
| 113 | * TCF4_22108803_ChIP-Seq_LS180_Human | 0.91097914 |
| 114 | MYB_26560356_Chip-Seq_TH2_Human | 0.90887374 |
| 115 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.90364501 |
| 116 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.90266393 |
| 117 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.89905354 |
| 118 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.89566774 |
| 119 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.89531480 |
| 120 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.89009669 |
| 121 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.88927768 |
| 122 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.88671126 |
| 123 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 0.88579944 |
| 124 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.88127926 |
| 125 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.86631513 |
| 126 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.86060904 |
| 127 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.83992673 |
| 128 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.83238321 |
| 129 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82962968 |
| 130 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.82609721 |
| 131 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.82543509 |
| 132 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.80863686 |
| 133 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.80220758 |
| 134 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.79957459 |
| 135 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.79901975 |
| 136 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.79252498 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 4.06883631 |
| 2 | MP0003787_abnormal_imprinting | 3.84727376 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.20816989 |
| 4 | MP0003121_genomic_imprinting | 2.80738562 |
| 5 | MP0003111_abnormal_nucleus_morphology | 2.69177768 |
| 6 | MP0008058_abnormal_DNA_repair | 2.64306317 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.54490981 |
| 8 | MP0006292_abnormal_olfactory_placode | 2.52769989 |
| 9 | MP0000566_synostosis | 2.43301515 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.41803049 |
| 11 | MP0000569_abnormal_digit_pigmentation | 2.41723241 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.37224241 |
| 13 | MP0003077_abnormal_cell_cycle | 2.32541846 |
| 14 | MP0002009_preneoplasia | 2.20249293 |
| 15 | MP0003693_abnormal_embryo_hatching | 2.10832368 |
| 16 | MP0004957_abnormal_blastocyst_morpholog | 1.78428916 |
| 17 | MP0002166_altered_tumor_susceptibility | 1.76845763 |
| 18 | MP0003890_abnormal_embryonic-extraembry | 1.73817878 |
| 19 | MP0000516_abnormal_urinary_system | 1.70409095 |
| 20 | MP0005367_renal/urinary_system_phenotyp | 1.70409095 |
| 21 | MP0004808_abnormal_hematopoietic_stem | 1.67978518 |
| 22 | MP0003123_paternal_imprinting | 1.66285009 |
| 23 | MP0001188_hyperpigmentation | 1.64262820 |
| 24 | MP0003941_abnormal_skin_development | 1.63970542 |
| 25 | MP0003937_abnormal_limbs/digits/tail_de | 1.63305663 |
| 26 | MP0001293_anophthalmia | 1.52675257 |
| 27 | MP0000350_abnormal_cell_proliferation | 1.43097309 |
| 28 | MP0002938_white_spotting | 1.35909540 |
| 29 | MP0005379_endocrine/exocrine_gland_phen | 1.34925323 |
| 30 | MP0003122_maternal_imprinting | 1.34175222 |
| 31 | MP0005409_darkened_coat_color | 1.31294436 |
| 32 | MP0002084_abnormal_developmental_patter | 1.30317291 |
| 33 | MP0001672_abnormal_embryogenesis/_devel | 1.27637429 |
| 34 | MP0005380_embryogenesis_phenotype | 1.27637429 |
| 35 | MP0000432_abnormal_head_morphology | 1.25092443 |
| 36 | MP0000631_abnormal_neuroendocrine_gland | 1.24558155 |
| 37 | MP0005220_abnormal_exocrine_pancreas | 1.24366263 |
| 38 | MP0003935_abnormal_craniofacial_develop | 1.23840397 |
| 39 | MP0000049_abnormal_middle_ear | 1.22879364 |
| 40 | MP0003567_abnormal_fetal_cardiomyocyte | 1.22678694 |
| 41 | MP0003385_abnormal_body_wall | 1.22659346 |
| 42 | MP0004197_abnormal_fetal_growth/weight/ | 1.21208951 |
| 43 | MP0002085_abnormal_embryonic_tissue | 1.21095901 |
| 44 | MP0001286_abnormal_eye_development | 1.20389564 |
| 45 | MP0008932_abnormal_embryonic_tissue | 1.19504617 |
| 46 | MP0009703_decreased_birth_body | 1.18988232 |
| 47 | MP0005645_abnormal_hypothalamus_physiol | 1.16900230 |
| 48 | MP0004264_abnormal_extraembryonic_tissu | 1.16282089 |
| 49 | MP0003755_abnormal_palate_morphology | 1.14916875 |
| 50 | MP0010307_abnormal_tumor_latency | 1.14276957 |
| 51 | MP0003786_premature_aging | 1.12794983 |
| 52 | MP0002249_abnormal_larynx_morphology | 1.10814456 |
| 53 | MP0003763_abnormal_thymus_physiology | 1.10370011 |
| 54 | MP0003984_embryonic_growth_retardation | 1.10036468 |
| 55 | MP0008961_abnormal_basal_metabolism | 1.09869544 |
| 56 | MP0003315_abnormal_perineum_morphology | 1.09428944 |
| 57 | MP0002086_abnormal_extraembryonic_tissu | 1.08858698 |
| 58 | MP0002088_abnormal_embryonic_growth/wei | 1.07743366 |
| 59 | MP0001697_abnormal_embryo_size | 1.07656445 |
| 60 | MP0002095_abnormal_skin_pigmentation | 1.06771413 |
| 61 | MP0010352_gastrointestinal_tract_polyps | 1.03649755 |
| 62 | MP0002109_abnormal_limb_morphology | 1.02745872 |
| 63 | MP0006072_abnormal_retinal_apoptosis | 1.02361332 |
| 64 | MP0005075_abnormal_melanosome_morpholog | 1.02130874 |
| 65 | MP0003115_abnormal_respiratory_system | 1.02115835 |
| 66 | MP0000427_abnormal_hair_cycle | 1.01904320 |
| 67 | MP0003119_abnormal_digestive_system | 1.01635752 |
| 68 | MP0002116_abnormal_craniofacial_bone | 1.01453007 |
| 69 | MP0001119_abnormal_female_reproductive | 1.01356994 |
| 70 | MP0000015_abnormal_ear_pigmentation | 1.00981293 |
| 71 | MP0009697_abnormal_copulation | 1.00002180 |
| 72 | MP0000428_abnormal_craniofacial_morphol | 0.99290848 |
| 73 | MP0008995_early_reproductive_senescence | 0.98322918 |
| 74 | MP0005076_abnormal_cell_differentiation | 0.96379064 |
| 75 | MP0005174_abnormal_tail_pigmentation | 0.94909388 |
| 76 | MP0003942_abnormal_urinary_system | 0.94559971 |
| 77 | MP0010678_abnormal_skin_adnexa | 0.94318972 |
| 78 | MP0002210_abnormal_sex_determination | 0.93630065 |
| 79 | MP0003718_maternal_effect | 0.93206356 |
| 80 | MP0009250_abnormal_appendicular_skeleto | 0.92389012 |
| 81 | MP0002006_tumorigenesis | 0.92268875 |
| 82 | MP0002114_abnormal_axial_skeleton | 0.90866011 |
| 83 | MP0001730_embryonic_growth_arrest | 0.90378206 |
| 84 | MP0005646_abnormal_pituitary_gland | 0.90289437 |
| 85 | MP0000703_abnormal_thymus_morphology | 0.90021998 |
| 86 | MP0002177_abnormal_outer_ear | 0.89405973 |
| 87 | MP0001145_abnormal_male_reproductive | 0.89314826 |
| 88 | MP0000383_abnormal_hair_follicle | 0.88986946 |
| 89 | MP0003943_abnormal_hepatobiliary_system | 0.88574599 |
| 90 | MP0005248_abnormal_Harderian_gland | 0.87720650 |
| 91 | MP0008789_abnormal_olfactory_epithelium | 0.86837378 |
| 92 | MP0002697_abnormal_eye_size | 0.85361130 |
| 93 | MP0002277_abnormal_respiratory_mucosa | 0.84030602 |
| 94 | MP0001915_intracranial_hemorrhage | 0.83905489 |
| 95 | MP0000653_abnormal_sex_gland | 0.83598744 |
| 96 | MP0000490_abnormal_crypts_of | 0.83189407 |
| 97 | MP0002163_abnormal_gland_morphology | 0.83140347 |
| 98 | MP0002075_abnormal_coat/hair_pigmentati | 0.83123381 |
| 99 | MP0001186_pigmentation_phenotype | 0.81922202 |
| 100 | MP0002925_abnormal_cardiovascular_devel | 0.81608608 |
| 101 | MP0002233_abnormal_nose_morphology | 0.80967587 |
| 102 | MP0003698_abnormal_male_reproductive | 0.80200503 |
| 103 | MP0010234_abnormal_vibrissa_follicle | 0.78596002 |
| 104 | MP0009053_abnormal_anal_canal | 0.78069369 |
| 105 | MP0001944_abnormal_pancreas_morphology | 0.77912668 |
| 106 | MP0003861_abnormal_nervous_system | 0.77358494 |
| 107 | MP0002092_abnormal_eye_morphology | 0.77201031 |
| 108 | MP0002932_abnormal_joint_morphology | 0.76367970 |
| 109 | MP0000313_abnormal_cell_death | 0.76014008 |
| 110 | MP0002080_prenatal_lethality | 0.74834076 |
| 111 | MP0005499_abnormal_olfactory_system | 0.74487035 |
| 112 | MP0005394_taste/olfaction_phenotype | 0.74487035 |
| 113 | MP0003936_abnormal_reproductive_system | 0.74130201 |
| 114 | MP0002111_abnormal_tail_morphology | 0.72652326 |
| 115 | MP0002928_abnormal_bile_duct | 0.72045469 |
| 116 | MP0002398_abnormal_bone_marrow | 0.71925896 |
| 117 | MP0002160_abnormal_reproductive_system | 0.71312953 |
| 118 | MP0009672_abnormal_birth_weight | 0.71234023 |
| 119 | MP0002019_abnormal_tumor_incidence | 0.71087681 |
| 120 | MP0001177_atelectasis | 0.70755290 |
| 121 | MP0001929_abnormal_gametogenesis | 0.70642065 |
| 122 | MP0000372_irregular_coat_pigmentation | 0.70368551 |
| 123 | MP0002638_abnormal_pupillary_reflex | 0.68016332 |
| 124 | MP0001984_abnormal_olfaction | 0.67088463 |
| 125 | MP0002102_abnormal_ear_morphology | 0.63699262 |
| 126 | MP0005253_abnormal_eye_physiology | 0.62961980 |
| 127 | MP0000689_abnormal_spleen_morphology | 0.62365478 |
| 128 | MP0005391_vision/eye_phenotype | 0.62330410 |
| 129 | MP0005389_reproductive_system_phenotype | 0.62320444 |
| 130 | MP0005310_abnormal_salivary_gland | 0.61626195 |
| 131 | MP0002138_abnormal_hepatobiliary_system | 0.61229333 |
| 132 | MP0002234_abnormal_pharynx_morphology | 0.56714448 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 4.02980089 |
| 2 | Chromsome breakage (HP:0040012) | 3.66175073 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.48343220 |
| 4 | Abnormality of the fingertips (HP:0001211) | 3.25315795 |
| 5 | Ectopic kidney (HP:0000086) | 2.94710636 |
| 6 | Urethral obstruction (HP:0000796) | 2.93698013 |
| 7 | Acute lymphatic leukemia (HP:0006721) | 2.83232061 |
| 8 | Abnormality of the nasal septum (HP:0000419) | 2.71779142 |
| 9 | Short 4th metacarpal (HP:0010044) | 2.56830102 |
| 10 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.56830102 |
| 11 | Panhypogammaglobulinemia (HP:0003139) | 2.51623063 |
| 12 | Absent frontal sinuses (HP:0002688) | 2.50828172 |
| 13 | Medulloblastoma (HP:0002885) | 2.48172083 |
| 14 | Thyroiditis (HP:0100646) | 2.47579986 |
| 15 | Severe combined immunodeficiency (HP:0004430) | 2.47261253 |
| 16 | Abnormality of chromosome stability (HP:0003220) | 2.47017857 |
| 17 | Aqueductal stenosis (HP:0002410) | 2.46759649 |
| 18 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.44213939 |
| 19 | Embryonal renal neoplasm (HP:0011794) | 2.41521860 |
| 20 | Lip pit (HP:0100267) | 2.38460571 |
| 21 | Intestinal fistula (HP:0100819) | 2.37974895 |
| 22 | Long eyelashes (HP:0000527) | 2.37559295 |
| 23 | Abnormality of DNA repair (HP:0003254) | 2.36292653 |
| 24 | Papillary thyroid carcinoma (HP:0002895) | 2.34929671 |
| 25 | Deep philtrum (HP:0002002) | 2.33672287 |
| 26 | Intestinal atresia (HP:0011100) | 2.33151115 |
| 27 | Astrocytoma (HP:0009592) | 2.32355612 |
| 28 | Abnormality of the astrocytes (HP:0100707) | 2.32355612 |
| 29 | Anal stenosis (HP:0002025) | 2.31288127 |
| 30 | Abnormality of the incisor (HP:0000676) | 2.31054882 |
| 31 | Abnormality of homocysteine metabolism (HP:0010919) | 2.27533917 |
| 32 | Homocystinuria (HP:0002156) | 2.27533917 |
| 33 | Midline defect of the nose (HP:0004122) | 2.20190674 |
| 34 | Birth length less than 3rd percentile (HP:0003561) | 2.17573942 |
| 35 | Abnormality of the labia minora (HP:0012880) | 2.16969976 |
| 36 | Abnormality of incisor morphology (HP:0011063) | 2.16599991 |
| 37 | Acute myeloid leukemia (HP:0004808) | 2.15641004 |
| 38 | Supernumerary ribs (HP:0005815) | 2.14997925 |
| 39 | Syringomyelia (HP:0003396) | 2.14470315 |
| 40 | Spinal cord lesions (HP:0100561) | 2.14470315 |
| 41 | Supernumerary spleens (HP:0009799) | 2.12862647 |
| 42 | Low anterior hairline (HP:0000294) | 2.12555589 |
| 43 | B lymphocytopenia (HP:0010976) | 2.11713343 |
| 44 | Meckel diverticulum (HP:0002245) | 2.10757787 |
| 45 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.10708263 |
| 46 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.09918625 |
| 47 | Combined immunodeficiency (HP:0005387) | 2.08649994 |
| 48 | Long clavicles (HP:0000890) | 2.07611726 |
| 49 | Tubulointerstitial nephritis (HP:0001970) | 2.06435792 |
| 50 | Genetic anticipation (HP:0003743) | 2.05525917 |
| 51 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.03894238 |
| 52 | Neoplasm of the oral cavity (HP:0100649) | 2.03736875 |
| 53 | Cystic hygroma (HP:0000476) | 2.03114131 |
| 54 | Abnormality of the preputium (HP:0100587) | 2.02761797 |
| 55 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.00563212 |
| 56 | Myelodysplasia (HP:0002863) | 1.99910168 |
| 57 | Sandal gap (HP:0001852) | 1.99719071 |
| 58 | Chronic hepatic failure (HP:0100626) | 1.99470012 |
| 59 | Abnormal biliary tract morphology (HP:0012440) | 1.98325685 |
| 60 | Abnormality of the ileum (HP:0001549) | 1.98266562 |
| 61 | Ependymoma (HP:0002888) | 1.97753272 |
| 62 | Abnormal number of incisors (HP:0011064) | 1.96572724 |
| 63 | Gaze-evoked nystagmus (HP:0000640) | 1.96137300 |
| 64 | Menstrual irregularities (HP:0000858) | 1.94895961 |
| 65 | Oligodactyly (hands) (HP:0001180) | 1.94815364 |
| 66 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.93980744 |
| 67 | Abnormality of B cell number (HP:0010975) | 1.93795632 |
| 68 | Neoplasm of striated muscle (HP:0009728) | 1.93310301 |
| 69 | Abnormal lung lobation (HP:0002101) | 1.93023153 |
| 70 | Impulsivity (HP:0100710) | 1.91572055 |
| 71 | Increased nuchal translucency (HP:0010880) | 1.88971298 |
| 72 | Abnormality of the columella (HP:0009929) | 1.88417200 |
| 73 | Preaxial hand polydactyly (HP:0001177) | 1.88343268 |
| 74 | Clubbing of toes (HP:0100760) | 1.88186857 |
| 75 | Neoplasm of the adrenal cortex (HP:0100641) | 1.88136005 |
| 76 | Abnormality of the renal cortex (HP:0011035) | 1.88111840 |
| 77 | Rectovaginal fistula (HP:0000143) | 1.87977807 |
| 78 | Rectal fistula (HP:0100590) | 1.87977807 |
| 79 | Optic nerve coloboma (HP:0000588) | 1.87698661 |
| 80 | Cutis marmorata (HP:0000965) | 1.87624210 |
| 81 | Abnormal hair whorl (HP:0010721) | 1.85710710 |
| 82 | Thyroid carcinoma (HP:0002890) | 1.85571835 |
| 83 | Cafe-au-lait spot (HP:0000957) | 1.85516627 |
| 84 | Overlapping toe (HP:0001845) | 1.85105224 |
| 85 | Trigonocephaly (HP:0000243) | 1.84898791 |
| 86 | Truncal obesity (HP:0001956) | 1.84309730 |
| 87 | Basal cell carcinoma (HP:0002671) | 1.84041858 |
| 88 | Biliary tract neoplasm (HP:0100574) | 1.83960462 |
| 89 | Shawl scrotum (HP:0000049) | 1.79949983 |
| 90 | Colon cancer (HP:0003003) | 1.78374085 |
| 91 | Pancreatic cysts (HP:0001737) | 1.78218803 |
| 92 | Increased number of teeth (HP:0011069) | 1.77412061 |
| 93 | Triphalangeal thumb (HP:0001199) | 1.76751460 |
| 94 | Limb hypertonia (HP:0002509) | 1.75872970 |
| 95 | 11 pairs of ribs (HP:0000878) | 1.74410795 |
| 96 | T lymphocytopenia (HP:0005403) | 1.74216478 |
| 97 | Selective tooth agenesis (HP:0001592) | 1.71720049 |
| 98 | Protruding tongue (HP:0010808) | 1.71334007 |
| 99 | Hypoplasia of the thymus (HP:0000778) | 1.70679154 |
| 100 | Fair hair (HP:0002286) | 1.70297712 |
| 101 | Pancreatic fibrosis (HP:0100732) | 1.69406152 |
| 102 | Glioma (HP:0009733) | 1.69305219 |
| 103 | Renal cortical cysts (HP:0000803) | 1.69018779 |
| 104 | Macroorchidism (HP:0000053) | 1.68706861 |
| 105 | Duodenal stenosis (HP:0100867) | 1.68551759 |
| 106 | Small intestinal stenosis (HP:0012848) | 1.68551759 |
| 107 | Rib fusion (HP:0000902) | 1.68291569 |
| 108 | Nephronophthisis (HP:0000090) | 1.68079032 |
| 109 | Renal hypoplasia (HP:0000089) | 1.66951436 |
| 110 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.66471599 |
| 111 | Heterotopia (HP:0002282) | 1.66382018 |
| 112 | Embryonal neoplasm (HP:0002898) | 1.66192319 |
| 113 | Abnormality of the frontal sinuses (HP:0002687) | 1.66117725 |
| 114 | Patellar aplasia (HP:0006443) | 1.65247656 |
| 115 | Skull defect (HP:0001362) | 1.64643384 |
| 116 | Curly hair (HP:0002212) | 1.64560333 |
| 117 | Abnormality of midbrain morphology (HP:0002418) | 1.64400277 |
| 118 | Molar tooth sign on MRI (HP:0002419) | 1.64400277 |
| 119 | Gastrointestinal atresia (HP:0002589) | 1.63932258 |
| 120 | Highly arched eyebrow (HP:0002553) | 1.63882470 |
| 121 | Sloping forehead (HP:0000340) | 1.63413539 |
| 122 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.63122902 |
| 123 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.63122902 |
| 124 | Facial hemangioma (HP:0000329) | 1.62507680 |
| 125 | Abnormality of the carotid arteries (HP:0005344) | 1.62474006 |
| 126 | Reticulocytopenia (HP:0001896) | 1.62294559 |
| 127 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.62094826 |
| 128 | Broad alveolar ridges (HP:0000187) | 1.61334738 |
| 129 | Hypoplastic iliac wings (HP:0002866) | 1.61131458 |
| 130 | Obsessive-compulsive behavior (HP:0000722) | 1.60442626 |
| 131 | Abnormality of the parietal bone (HP:0002696) | 1.60224103 |
| 132 | Drooling (HP:0002307) | 1.60141128 |
| 133 | Hypochromic microcytic anemia (HP:0004840) | 1.59694056 |
| 134 | Hypoplasia of the maxilla (HP:0000327) | 1.59651102 |
| 135 | Arteriovenous malformation (HP:0100026) | 1.59245256 |
| 136 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.58345196 |
| 137 | Neoplasm of the small intestine (HP:0100833) | 1.58121552 |
| 138 | High anterior hairline (HP:0009890) | 1.57663029 |
| 139 | Rhabdomyosarcoma (HP:0002859) | 1.57285102 |
| 140 | Deviation of the thumb (HP:0009603) | 1.56859878 |
| 141 | Absent radius (HP:0003974) | 1.56055637 |
| 142 | Prominent nose (HP:0000448) | 1.55823440 |
| 143 | Abnormality of the renal medulla (HP:0100957) | 1.55640624 |
| 144 | Abnormality of the duodenum (HP:0002246) | 1.55592608 |
| 145 | Median cleft lip (HP:0000161) | 1.54917802 |
| 146 | Hypospadias (HP:0000047) | 1.54271984 |
| 147 | Renal dysplasia (HP:0000110) | 1.53954557 |
| 148 | Febrile seizures (HP:0002373) | 1.53860825 |
| 149 | Thickened helices (HP:0000391) | 1.53285425 |
| 150 | Abnormality of chromosome segregation (HP:0002916) | 1.53094976 |
| 151 | Broad thumb (HP:0011304) | 1.52624964 |
| 152 | True hermaphroditism (HP:0010459) | 1.52538086 |
| 153 | Postaxial foot polydactyly (HP:0001830) | 1.52394360 |
| 154 | Aplasia/Hypoplasia involving the sinuses (HP:0009120) | 1.52296964 |
| 155 | Degeneration of anterior horn cells (HP:0002398) | 1.52123759 |
| 156 | Abnormality of the anterior horn cell (HP:0006802) | 1.52123759 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MKNK2 | 4.04762985 |
| 2 | MKNK1 | 3.64960728 |
| 3 | CDK12 | 3.44517743 |
| 4 | CDC7 | 3.16820242 |
| 5 | BRD4 | 2.91000392 |
| 6 | ZAK | 2.81212992 |
| 7 | SRPK1 | 2.63233782 |
| 8 | LATS1 | 2.47721860 |
| 9 | TAF1 | 2.44892235 |
| 10 | NUAK1 | 2.11093682 |
| 11 | FGFR2 | 2.01479322 |
| 12 | ERBB3 | 1.96596737 |
| 13 | TTK | 1.88238164 |
| 14 | NEK2 | 1.78827768 |
| 15 | MAP3K10 | 1.76385519 |
| 16 | ATR | 1.74100788 |
| 17 | AKT3 | 1.70392515 |
| 18 | PLK4 | 1.69480890 |
| 19 | MAP3K14 | 1.60626880 |
| 20 | YES1 | 1.57473111 |
| 21 | STK38L | 1.56450571 |
| 22 | SGK2 | 1.55204271 |
| 23 | CHEK2 | 1.45871945 |
| 24 | NEK6 | 1.44460622 |
| 25 | PLK3 | 1.44114322 |
| 26 | EIF2AK2 | 1.39650111 |
| 27 | STK3 | 1.39191324 |
| 28 | TXK | 1.35656817 |
| 29 | ATM | 1.31132574 |
| 30 | TNIK | 1.27925555 |
| 31 | PNCK | 1.26812504 |
| 32 | FGFR3 | 1.26681156 |
| 33 | CDK3 | 1.25123822 |
| 34 | FRK | 1.24732692 |
| 35 | SGK3 | 1.21641716 |
| 36 | BMPR2 | 1.16459656 |
| 37 | * CHEK1 | 1.15242550 |
| 38 | SIK3 | 1.15234751 |
| 39 | ACVR1B | 1.11900167 |
| 40 | CHUK | 1.08587887 |
| 41 | CDK7 | 1.05732071 |
| 42 | PLK1 | 1.05228389 |
| 43 | PASK | 1.03243495 |
| 44 | CLK1 | 1.02021831 |
| 45 | TRIM28 | 1.01622493 |
| 46 | RPS6KB2 | 0.98110096 |
| 47 | CDK8 | 0.97839137 |
| 48 | STK4 | 0.97772063 |
| 49 | CAMK1G | 0.97239989 |
| 50 | CDK9 | 0.95349183 |
| 51 | PLK2 | 0.92898393 |
| 52 | WEE1 | 0.92291944 |
| 53 | AURKB | 0.92286048 |
| 54 | CDK6 | 0.92019033 |
| 55 | JAK3 | 0.91675287 |
| 56 | CDK2 | 0.91247391 |
| 57 | VRK1 | 0.89428895 |
| 58 | WNK3 | 0.88938903 |
| 59 | STK24 | 0.86288609 |
| 60 | PIM1 | 0.86172288 |
| 61 | SIK2 | 0.85790613 |
| 62 | MST4 | 0.83669618 |
| 63 | CDK1 | 0.82223977 |
| 64 | CDK19 | 0.81651530 |
| 65 | BRSK2 | 0.80069247 |
| 66 | CDK4 | 0.78612472 |
| 67 | MAPK14 | 0.78132245 |
| 68 | RPS6KB1 | 0.77837271 |
| 69 | MELK | 0.75825347 |
| 70 | MAPK13 | 0.75593202 |
| 71 | TEC | 0.74339255 |
| 72 | EIF2AK1 | 0.73848995 |
| 73 | CAMK1D | 0.73293154 |
| 74 | MAP4K2 | 0.73287475 |
| 75 | MAP3K4 | 0.72828216 |
| 76 | PINK1 | 0.70358800 |
| 77 | STK39 | 0.70315718 |
| 78 | DYRK3 | 0.68597850 |
| 79 | CSNK1A1L | 0.68196691 |
| 80 | MAP3K6 | 0.67101426 |
| 81 | NEK9 | 0.66077219 |
| 82 | FLT3 | 0.65632703 |
| 83 | PIK3CA | 0.63934934 |
| 84 | CASK | 0.63833423 |
| 85 | EEF2K | 0.62700628 |
| 86 | PRKDC | 0.62175873 |
| 87 | CAMKK2 | 0.61726490 |
| 88 | MAP3K13 | 0.60548135 |
| 89 | BMPR1B | 0.60386477 |
| 90 | GSK3B | 0.59557740 |
| 91 | ITK | 0.59304791 |
| 92 | STK11 | 0.55118630 |
| 93 | MAP2K7 | 0.55026096 |
| 94 | AKT1 | 0.54580904 |
| 95 | MARK3 | 0.54216689 |
| 96 | SGK1 | 0.54203596 |
| 97 | BCR | 0.52340652 |
| 98 | CSNK1D | 0.51852935 |
| 99 | TRPM7 | 0.50877028 |
| 100 | PRPF4B | 0.48832529 |
| 101 | DYRK1A | 0.47761633 |
| 102 | IRAK4 | 0.46587972 |
| 103 | ALK | 0.46232459 |
| 104 | MAPK8 | 0.44676400 |
| 105 | MAPK1 | 0.44371865 |
| 106 | UHMK1 | 0.43471103 |
| 107 | INSRR | 0.43218539 |
| 108 | BTK | 0.42951729 |
| 109 | PBK | 0.42817934 |
| 110 | MAPK10 | 0.42772658 |
| 111 | MAP3K2 | 0.42116243 |
| 112 | MTOR | 0.39646403 |
| 113 | KSR1 | 0.38987547 |
| 114 | OXSR1 | 0.38688721 |
| 115 | TSSK6 | 0.38223133 |
| 116 | NLK | 0.37445059 |
| 117 | WNK1 | 0.36979313 |
| 118 | BUB1 | 0.36685521 |
| 119 | CSNK1E | 0.36615437 |
| 120 | SGK223 | 0.35807951 |
| 121 | SGK494 | 0.35807951 |
| 122 | FGFR1 | 0.35673996 |
| 123 | RPS6KA4 | 0.33838257 |
| 124 | TGFBR1 | 0.32790037 |
| 125 | EIF2AK3 | 0.32741257 |
| 126 | CSNK1G1 | 0.32512272 |
| 127 | CSNK2A2 | 0.32438519 |
| 128 | CSNK2A1 | 0.31366528 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mismatch repair_Homo sapiens_hsa03430 | 2.96456902 |
| 2 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.68614910 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 2.50534904 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.44744301 |
| 5 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.20899066 |
| 6 | Cell cycle_Homo sapiens_hsa04110 | 2.20279629 |
| 7 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.11645261 |
| 8 | RNA degradation_Homo sapiens_hsa03018 | 2.11074552 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.09612856 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.07221205 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.00380643 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 1.95515286 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 1.89426487 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.85347407 |
| 15 | Protein export_Homo sapiens_hsa03060 | 1.56555026 |
| 16 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.51756851 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.50903317 |
| 18 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.48907734 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.43654823 |
| 20 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.40859621 |
| 21 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.32674695 |
| 22 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.24645183 |
| 23 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.22763096 |
| 24 | Lysine degradation_Homo sapiens_hsa00310 | 1.22147596 |
| 25 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.21525435 |
| 26 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.20609455 |
| 27 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.19252827 |
| 28 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.18866195 |
| 29 | Adherens junction_Homo sapiens_hsa04520 | 1.16852983 |
| 30 | HTLV-I infection_Homo sapiens_hsa05166 | 1.06651518 |
| 31 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.05142638 |
| 32 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.04851789 |
| 33 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.03510143 |
| 34 | Measles_Homo sapiens_hsa05162 | 1.00570902 |
| 35 | Prostate cancer_Homo sapiens_hsa05215 | 1.00158734 |
| 36 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.99261923 |
| 37 | RNA polymerase_Homo sapiens_hsa03020 | 0.93506282 |
| 38 | Colorectal cancer_Homo sapiens_hsa05210 | 0.93182263 |
| 39 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.92617990 |
| 40 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.90859906 |
| 41 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.90736718 |
| 42 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.89776740 |
| 43 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.88676009 |
| 44 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.86922432 |
| 45 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.85364942 |
| 46 | Endometrial cancer_Homo sapiens_hsa05213 | 0.84931628 |
| 47 | Taste transduction_Homo sapiens_hsa04742 | 0.84918999 |
| 48 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.84688917 |
| 49 | Long-term depression_Homo sapiens_hsa04730 | 0.83633994 |
| 50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.81657660 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.81353365 |
| 52 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.80745197 |
| 53 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.80145602 |
| 54 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.80110048 |
| 55 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.80044495 |
| 56 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.79440477 |
| 57 | Pathways in cancer_Homo sapiens_hsa05200 | 0.78867853 |
| 58 | Influenza A_Homo sapiens_hsa05164 | 0.78829125 |
| 59 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.77911403 |
| 60 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.77680762 |
| 61 | Hepatitis B_Homo sapiens_hsa05161 | 0.77064217 |
| 62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.76360047 |
| 63 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.73978285 |
| 64 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.73709966 |
| 65 | Allograft rejection_Homo sapiens_hsa05330 | 0.73666196 |
| 66 | Long-term potentiation_Homo sapiens_hsa04720 | 0.73584882 |
| 67 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.72875221 |
| 68 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.72864318 |
| 69 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.72134588 |
| 70 | Olfactory transduction_Homo sapiens_hsa04740 | 0.71605682 |
| 71 | Melanoma_Homo sapiens_hsa05218 | 0.71391193 |
| 72 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.71249829 |
| 73 | Thyroid cancer_Homo sapiens_hsa05216 | 0.70196159 |
| 74 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.69988259 |
| 75 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.69649337 |
| 76 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.69158939 |
| 77 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.65937970 |
| 78 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.65844794 |
| 79 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.65098156 |
| 80 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.64147366 |
| 81 | Glioma_Homo sapiens_hsa05214 | 0.63167538 |
| 82 | Viral myocarditis_Homo sapiens_hsa05416 | 0.62318681 |
| 83 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.62242556 |
| 84 | Ribosome_Homo sapiens_hsa03010 | 0.62216738 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.62074301 |
| 86 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.61293959 |
| 87 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.59944655 |
| 88 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.59765938 |
| 89 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.59000171 |
| 90 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.57707155 |
| 91 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.56122838 |
| 92 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.55874735 |
| 93 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.55857914 |
| 94 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.55667039 |
| 95 | Purine metabolism_Homo sapiens_hsa00230 | 0.55665004 |
| 96 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.55414250 |
| 97 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.55161127 |
| 98 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.54224344 |
| 99 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.52677200 |
| 100 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.52603220 |
| 101 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.51433857 |
| 102 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.51363962 |
| 103 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.50618800 |
| 104 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.49553204 |
| 105 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.48617165 |
| 106 | Alcoholism_Homo sapiens_hsa05034 | 0.48552682 |
| 107 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.48121498 |
| 108 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.47463883 |
| 109 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.47383935 |
| 110 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.46688670 |
| 111 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.46520195 |
| 112 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.46377301 |
| 113 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.46140223 |
| 114 | Phototransduction_Homo sapiens_hsa04744 | 0.46037677 |
| 115 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.45998243 |
| 116 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.45603301 |
| 117 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44474189 |
| 118 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.43491358 |
| 119 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.43205983 |
| 120 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.42906997 |
| 121 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.41723474 |
| 122 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.41557562 |
| 123 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.40542944 |
| 124 | Circadian rhythm_Homo sapiens_hsa04710 | 0.39965804 |
| 125 | Renin secretion_Homo sapiens_hsa04924 | 0.39862504 |
| 126 | Nicotine addiction_Homo sapiens_hsa05033 | 0.39411016 |
| 127 | Platelet activation_Homo sapiens_hsa04611 | 0.39173264 |
| 128 | Insulin secretion_Homo sapiens_hsa04911 | 0.38940494 |
| 129 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.38556918 |
| 130 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37387110 |
| 131 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.37052618 |
| 132 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.36451283 |
| 133 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.36340570 |
| 134 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.35364893 |
| 135 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.35154119 |

