

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.13827098 |
| 2 | nuclear pore organization (GO:0006999) | 5.93523999 |
| 3 | mitotic sister chromatid cohesion (GO:0007064) | 5.56341513 |
| 4 | pore complex assembly (GO:0046931) | 4.71796654 |
| 5 | mitotic metaphase plate congression (GO:0007080) | 4.46780664 |
| 6 | regulation of RNA export from nucleus (GO:0046831) | 4.42005397 |
| 7 | kinetochore organization (GO:0051383) | 4.31016515 |
| 8 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 4.11527019 |
| 9 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 4.11527019 |
| 10 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 4.11527019 |
| 11 | protein localization to kinetochore (GO:0034501) | 4.10976227 |
| 12 | mitotic nuclear envelope disassembly (GO:0007077) | 4.07872639 |
| 13 | metaphase plate congression (GO:0051310) | 3.97874913 |
| 14 | negative regulation of histone methylation (GO:0031061) | 3.94716829 |
| 15 | establishment of integrated proviral latency (GO:0075713) | 3.92946552 |
| 16 | protein localization to chromosome, centromeric region (GO:0071459) | 3.92903932 |
| 17 | negative regulation of DNA repair (GO:0045738) | 3.89418182 |
| 18 | mitotic chromosome condensation (GO:0007076) | 3.87464829 |
| 19 | pre-miRNA processing (GO:0031054) | 3.86187335 |
| 20 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.84795958 |
| 21 | membrane disassembly (GO:0030397) | 3.79773497 |
| 22 | nuclear envelope disassembly (GO:0051081) | 3.79773497 |
| 23 | regulation of histone H3-K9 methylation (GO:0051570) | 3.75434608 |
| 24 | kinetochore assembly (GO:0051382) | 3.75179436 |
| 25 | positive regulation of chromosome segregation (GO:0051984) | 3.74337302 |
| 26 | DNA strand elongation (GO:0022616) | 3.68912440 |
| 27 | negative regulation of chromosome segregation (GO:0051985) | 3.68005832 |
| 28 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.64218753 |
| 29 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.64218753 |
| 30 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.64218753 |
| 31 | negative regulation of sister chromatid segregation (GO:0033046) | 3.64218753 |
| 32 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.64218753 |
| 33 | sister chromatid cohesion (GO:0007062) | 3.63117594 |
| 34 | paraxial mesoderm development (GO:0048339) | 3.61751760 |
| 35 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.60751056 |
| 36 | meiotic chromosome segregation (GO:0045132) | 3.58428409 |
| 37 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.57993332 |
| 38 | non-recombinational repair (GO:0000726) | 3.57993332 |
| 39 | establishment of chromosome localization (GO:0051303) | 3.56827549 |
| 40 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.53097234 |
| 41 | mitotic spindle checkpoint (GO:0071174) | 3.47530533 |
| 42 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.45420203 |
| 43 | mitotic sister chromatid segregation (GO:0000070) | 3.40667229 |
| 44 | protein complex localization (GO:0031503) | 3.39720856 |
| 45 | mitotic spindle assembly checkpoint (GO:0007094) | 3.39356787 |
| 46 | sister chromatid segregation (GO:0000819) | 3.39005554 |
| 47 | regulation of sister chromatid cohesion (GO:0007063) | 3.34097588 |
| 48 | regulation of DNA endoreduplication (GO:0032875) | 3.33215871 |
| 49 | spindle assembly checkpoint (GO:0071173) | 3.31003026 |
| 50 | cellular protein complex localization (GO:0034629) | 3.30011549 |
| 51 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.28820095 |
| 52 | regulation of spindle organization (GO:0090224) | 3.27269314 |
| 53 | DNA replication checkpoint (GO:0000076) | 3.26791144 |
| 54 | histone H2A monoubiquitination (GO:0035518) | 3.25007503 |
| 55 | regulation of centriole replication (GO:0046599) | 3.24849571 |
| 56 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.22327011 |
| 57 | DNA replication-independent nucleosome organization (GO:0034724) | 3.20346583 |
| 58 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.20346583 |
| 59 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.19155883 |
| 60 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.19155883 |
| 61 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.19114583 |
| 62 | protein localization to chromosome (GO:0034502) | 3.17793343 |
| 63 | chromatin remodeling at centromere (GO:0031055) | 3.16811544 |
| 64 | mitotic recombination (GO:0006312) | 3.16166493 |
| 65 | telomere maintenance via recombination (GO:0000722) | 3.16102302 |
| 66 | dosage compensation (GO:0007549) | 3.15381195 |
| 67 | mitotic G2/M transition checkpoint (GO:0044818) | 3.12565308 |
| 68 | formation of translation preinitiation complex (GO:0001731) | 3.10662371 |
| 69 | CENP-A containing nucleosome assembly (GO:0034080) | 3.10211950 |
| 70 | chromatin assembly or disassembly (GO:0006333) | 3.10109086 |
| 71 | DNA synthesis involved in DNA repair (GO:0000731) | 3.09987919 |
| 72 | regulation of centrosome duplication (GO:0010824) | 3.09404890 |
| 73 | histone exchange (GO:0043486) | 3.07264007 |
| 74 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.06588006 |
| 75 | regulation of mitotic spindle organization (GO:0060236) | 3.06186092 |
| 76 | ATP-dependent chromatin remodeling (GO:0043044) | 3.05860349 |
| 77 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.04408070 |
| 78 | regulation of helicase activity (GO:0051095) | 3.01824118 |
| 79 | regulation of translational fidelity (GO:0006450) | 3.00376921 |
| 80 | histone H2B ubiquitination (GO:0033523) | 3.00032172 |
| 81 | DNA unwinding involved in DNA replication (GO:0006268) | 2.99737823 |
| 82 | regulation of centrosome cycle (GO:0046605) | 2.99244872 |
| 83 | protein K6-linked ubiquitination (GO:0085020) | 2.99182151 |
| 84 | DNA geometric change (GO:0032392) | 2.98509371 |
| 85 | negative regulation of fibroblast apoptotic process (GO:2000270) | 2.97922289 |
| 86 | DNA duplex unwinding (GO:0032508) | 2.97721978 |
| 87 | embryonic process involved in female pregnancy (GO:0060136) | 2.96281371 |
| 88 | DNA replication initiation (GO:0006270) | 2.95054770 |
| 89 | chromosome condensation (GO:0030261) | 2.94267111 |
| 90 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 2.93174579 |
| 91 | negative regulation of G2/M transition of mitotic cell cycle (GO:0010972) | 2.92587609 |
| 92 | regulation of chromosome segregation (GO:0051983) | 2.92430844 |
| 93 | microtubule depolymerization (GO:0007019) | 2.91895223 |
| 94 | chromosome segregation (GO:0007059) | 2.91768750 |
| 95 | histone mRNA catabolic process (GO:0071044) | 2.90863408 |
| 96 | protein export from nucleus (GO:0006611) | 2.89467217 |
| 97 | chromatin assembly (GO:0031497) | 2.89198078 |
| 98 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.88229708 |
| 99 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.88124188 |
| 100 | nuclear envelope organization (GO:0006998) | 2.88061809 |
| 101 | spindle checkpoint (GO:0031577) | 2.87899695 |
| 102 | heterochromatin organization (GO:0070828) | 2.87427888 |
| 103 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.85474095 |
| 104 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.84782752 |
| 105 | ribosome assembly (GO:0042255) | 2.84324944 |
| 106 | negative regulation of cell cycle G2/M phase transition (GO:1902750) | 2.84124920 |
| 107 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.83941757 |
| 108 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.83941757 |
| 109 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.83563699 |
| 110 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.82028209 |
| 111 | mRNA transport (GO:0051028) | 2.82025424 |
| 112 | negative regulation of histone modification (GO:0031057) | 2.78616470 |
| 113 | regulation of sister chromatid segregation (GO:0033045) | 2.74795424 |
| 114 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.74795424 |
| 115 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.74795424 |
| 116 | mRNA stabilization (GO:0048255) | 2.71181514 |
| 117 | RNA stabilization (GO:0043489) | 2.71181514 |
| 118 | negative regulation of chromatin modification (GO:1903309) | 2.70710663 |
| 119 | DNA conformation change (GO:0071103) | 2.70487080 |
| 120 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 2.70415494 |
| 121 | regulation of double-strand break repair (GO:2000779) | 2.69326160 |
| 122 | gene silencing by RNA (GO:0031047) | 2.68775584 |
| 123 | replication fork processing (GO:0031297) | 2.68336562 |
| 124 | centriole replication (GO:0007099) | 2.67014840 |
| 125 | intra-S DNA damage checkpoint (GO:0031573) | 2.67004373 |
| 126 | histone H4-K12 acetylation (GO:0043983) | 2.65149101 |
| 127 | regulation of histone methylation (GO:0031060) | 2.64055083 |
| 128 | nucleus organization (GO:0006997) | 2.63542998 |
| 129 | maturation of 5.8S rRNA (GO:0000460) | 2.62692428 |
| 130 | histone H3-K9 methylation (GO:0051567) | 2.61928324 |
| 131 | microtubule cytoskeleton organization involved in mitosis (GO:1902850) | 2.60402720 |
| 132 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 2.60389951 |
| 133 | DNA packaging (GO:0006323) | 2.60013516 |
| 134 | DNA topological change (GO:0006265) | 2.59958675 |
| 135 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.59720046 |
| 136 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.59720046 |
| 137 | nucleic acid transport (GO:0050657) | 2.58921726 |
| 138 | establishment of RNA localization (GO:0051236) | 2.58921726 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.65826711 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.44425051 |
| 3 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.57808124 |
| 4 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.56430768 |
| 5 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.36152225 |
| 6 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.24034934 |
| 7 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 3.05813657 |
| 8 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.78590310 |
| 9 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.70409639 |
| 10 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.64620715 |
| 11 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.60675750 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.09999698 |
| 13 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.05892325 |
| 14 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.4910918 |
| 15 | MYC_22102868_ChIP-Seq_BL_Human | 1.96060933 |
| 16 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.95759061 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.95549455 |
| 18 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.95098484 |
| 19 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.81591945 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.75946434 |
| 21 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.75176717 |
| 22 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.72823133 |
| 23 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.68277538 |
| 24 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.64103835 |
| 25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.63625750 |
| 26 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.62823014 |
| 27 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.62506955 |
| 28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.58263799 |
| 29 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.57293908 |
| 30 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.57147278 |
| 31 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.49837727 |
| 32 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.48244395 |
| 33 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.47580125 |
| 34 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.44126404 |
| 35 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.39664885 |
| 36 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.36854249 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.33978704 |
| 38 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.32429308 |
| 39 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.30183123 |
| 40 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.28810588 |
| 41 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.27025096 |
| 42 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.25750399 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.25019805 |
| 44 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.24968419 |
| 45 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.23411930 |
| 46 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.22378005 |
| 47 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.20599251 |
| 48 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.20311954 |
| 49 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.20195926 |
| 50 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.19997873 |
| 51 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.19082719 |
| 52 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.17141443 |
| 53 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.16441071 |
| 54 | FUS_26573619_Chip-Seq_HEK293_Human | 1.15926188 |
| 55 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.15788882 |
| 56 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.15610989 |
| 57 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.14475570 |
| 58 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.13927289 |
| 59 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.13137420 |
| 60 | * PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.12684169 |
| 61 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.12563436 |
| 62 | MYB_26560356_Chip-Seq_TH1_Human | 1.12425587 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.11987330 |
| 64 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.10093950 |
| 65 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.07498970 |
| 66 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.06470710 |
| 67 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.06146252 |
| 68 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.05937277 |
| 69 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.03913797 |
| 70 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.03432863 |
| 71 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.03017454 |
| 72 | GATA1_22025678_ChIP-Seq_K562_Human | 1.02767506 |
| 73 | EWS_26573619_Chip-Seq_HEK293_Human | 1.01263081 |
| 74 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.00853823 |
| 75 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00073393 |
| 76 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.00070335 |
| 77 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.99460063 |
| 78 | MYB_26560356_Chip-Seq_TH2_Human | 0.99178843 |
| 79 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.98713300 |
| 80 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.97307659 |
| 81 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.96695090 |
| 82 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96486229 |
| 83 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.95973536 |
| 84 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.95232974 |
| 85 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.94239257 |
| 86 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.94009109 |
| 87 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92401727 |
| 88 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89676871 |
| 89 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.86990999 |
| 90 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.86315820 |
| 91 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.85070367 |
| 92 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.83998920 |
| 93 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.83452032 |
| 94 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.83060516 |
| 95 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.82826841 |
| 96 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.81980658 |
| 97 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.81889895 |
| 98 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81563737 |
| 99 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.81349467 |
| 100 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.80473532 |
| 101 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.79768898 |
| 102 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.79495388 |
| 103 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.78825791 |
| 104 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.78094517 |
| 105 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.77903033 |
| 106 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.77350246 |
| 107 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.77216647 |
| 108 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.76960560 |
| 109 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.76481014 |
| 110 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.76281096 |
| 111 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.76258883 |
| 112 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.76191362 |
| 113 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.75804280 |
| 114 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.75804280 |
| 115 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.75680604 |
| 116 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.73465285 |
| 117 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.73036420 |
| 118 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.72589206 |
| 119 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.72589206 |
| 120 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.72589206 |
| 121 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.72252441 |
| 122 | UTX_26944678_Chip-Seq_JUKART_Human | 0.70984450 |
| 123 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.70741091 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.24204656 |
| 2 | MP0008057_abnormal_DNA_replication | 4.00396749 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.82320831 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.51344355 |
| 5 | MP0003077_abnormal_cell_cycle | 3.39189866 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.05141565 |
| 7 | MP0008877_abnormal_DNA_methylation | 3.04750613 |
| 8 | MP0008058_abnormal_DNA_repair | 2.67039233 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.59958631 |
| 10 | MP0010307_abnormal_tumor_latency | 2.56742673 |
| 11 | MP0010352_gastrointestinal_tract_polyps | 2.41452709 |
| 12 | MP0010234_abnormal_vibrissa_follicle | 2.25939187 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.22194201 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.19599432 |
| 15 | MP0003123_paternal_imprinting | 2.18005038 |
| 16 | MP0003705_abnormal_hypodermis_morpholog | 2.15183187 |
| 17 | MP0003121_genomic_imprinting | 2.10841708 |
| 18 | MP0003787_abnormal_imprinting | 2.09140287 |
| 19 | MP0002877_abnormal_melanocyte_morpholog | 2.06705228 |
| 20 | MP0005076_abnormal_cell_differentiation | 2.03050181 |
| 21 | MP0001730_embryonic_growth_arrest | 1.98815973 |
| 22 | MP0003890_abnormal_embryonic-extraembry | 1.88287671 |
| 23 | MP0004808_abnormal_hematopoietic_stem | 1.88025679 |
| 24 | MP0005380_embryogenesis_phenotype | 1.83476138 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.83476138 |
| 26 | MP0002084_abnormal_developmental_patter | 1.72933037 |
| 27 | MP0003984_embryonic_growth_retardation | 1.72036196 |
| 28 | MP0002088_abnormal_embryonic_growth/wei | 1.67284033 |
| 29 | MP0004185_abnormal_adipocyte_glucose | 1.64684333 |
| 30 | MP0001697_abnormal_embryo_size | 1.61152538 |
| 31 | MP0006292_abnormal_olfactory_placode | 1.60143847 |
| 32 | MP0002085_abnormal_embryonic_tissue | 1.58549621 |
| 33 | MP0008932_abnormal_embryonic_tissue | 1.56121024 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.55906495 |
| 35 | MP0002086_abnormal_extraembryonic_tissu | 1.53930053 |
| 36 | MP0009697_abnormal_copulation | 1.49515258 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.44932066 |
| 38 | MP0002210_abnormal_sex_determination | 1.38222066 |
| 39 | MP0005397_hematopoietic_system_phenotyp | 1.36550363 |
| 40 | MP0001545_abnormal_hematopoietic_system | 1.36550363 |
| 41 | MP0001293_anophthalmia | 1.36269592 |
| 42 | MP0000490_abnormal_crypts_of | 1.33243094 |
| 43 | MP0002796_impaired_skin_barrier | 1.31572134 |
| 44 | MP0010678_abnormal_skin_adnexa | 1.29265931 |
| 45 | MP0000703_abnormal_thymus_morphology | 1.27811382 |
| 46 | MP0003786_premature_aging | 1.26734330 |
| 47 | MP0002080_prenatal_lethality | 1.25717614 |
| 48 | MP0008789_abnormal_olfactory_epithelium | 1.24616942 |
| 49 | MP0000569_abnormal_digit_pigmentation | 1.23682677 |
| 50 | MP0003937_abnormal_limbs/digits/tail_de | 1.23053705 |
| 51 | MP0001929_abnormal_gametogenesis | 1.22533269 |
| 52 | MP0004233_abnormal_muscle_weight | 1.22434912 |
| 53 | MP0003221_abnormal_cardiomyocyte_apopto | 1.20209385 |
| 54 | MP0002398_abnormal_bone_marrow | 1.16822597 |
| 55 | MP0000313_abnormal_cell_death | 1.16475026 |
| 56 | MP0003136_yellow_coat_color | 1.16228519 |
| 57 | MP0003567_abnormal_fetal_cardiomyocyte | 1.15026596 |
| 58 | MP0002006_tumorigenesis | 1.10050573 |
| 59 | MP0002019_abnormal_tumor_incidence | 1.09589976 |
| 60 | MP0001145_abnormal_male_reproductive | 1.06841716 |
| 61 | MP0000653_abnormal_sex_gland | 1.03716266 |
| 62 | MP0009703_decreased_birth_body | 1.03689780 |
| 63 | MP0009053_abnormal_anal_canal | 1.02857608 |
| 64 | MP0003566_abnormal_cell_adhesion | 1.02813571 |
| 65 | MP0002254_reproductive_system_inflammat | 1.02347802 |
| 66 | MP0002163_abnormal_gland_morphology | 1.00241345 |
| 67 | MP0000537_abnormal_urethra_morphology | 1.00228707 |
| 68 | MP0000432_abnormal_head_morphology | 1.00190521 |
| 69 | MP0003941_abnormal_skin_development | 0.98544182 |
| 70 | MP0009278_abnormal_bone_marrow | 0.96899698 |
| 71 | MP0005394_taste/olfaction_phenotype | 0.96842065 |
| 72 | MP0005499_abnormal_olfactory_system | 0.96842065 |
| 73 | MP0003453_abnormal_keratinocyte_physiol | 0.95437132 |
| 74 | MP0002009_preneoplasia | 0.94473198 |
| 75 | MP0002102_abnormal_ear_morphology | 0.93651794 |
| 76 | MP0001119_abnormal_female_reproductive | 0.92884942 |
| 77 | MP0001915_intracranial_hemorrhage | 0.92471603 |
| 78 | MP0000428_abnormal_craniofacial_morphol | 0.91308694 |
| 79 | MP0001286_abnormal_eye_development | 0.91086768 |
| 80 | MP0002722_abnormal_immune_system | 0.90335971 |
| 81 | MP0003935_abnormal_craniofacial_develop | 0.89840112 |
| 82 | MP0001849_ear_inflammation | 0.89832116 |
| 83 | MP0005501_abnormal_skin_physiology | 0.88763202 |
| 84 | MP0002925_abnormal_cardiovascular_devel | 0.86792211 |
| 85 | MP0000377_abnormal_hair_follicle | 0.86346599 |
| 86 | MP0000566_synostosis | 0.86176608 |
| 87 | MP0002166_altered_tumor_susceptibility | 0.85453965 |
| 88 | MP0000689_abnormal_spleen_morphology | 0.84861187 |
| 89 | MP0004264_abnormal_extraembryonic_tissu | 0.84085670 |
| 90 | MP0009672_abnormal_birth_weight | 0.83541049 |
| 91 | MP0003300_gastrointestinal_ulcer | 0.82092847 |
| 92 | MP0002111_abnormal_tail_morphology | 0.82011043 |
| 93 | MP0000427_abnormal_hair_cycle | 0.80886307 |
| 94 | MP0010030_abnormal_orbit_morphology | 0.80769626 |
| 95 | MP0001661_extended_life_span | 0.79577140 |
| 96 | MP0003755_abnormal_palate_morphology | 0.79540796 |
| 97 | MP0003656_abnormal_erythrocyte_physiolo | 0.78475226 |
| 98 | MP0000516_abnormal_urinary_system | 0.77919796 |
| 99 | MP0005367_renal/urinary_system_phenotyp | 0.77919796 |
| 100 | MP0005621_abnormal_cell_physiology | 0.75904112 |
| 101 | MP0003119_abnormal_digestive_system | 0.75889401 |
| 102 | MP0002060_abnormal_skin_morphology | 0.75148810 |
| 103 | MP0002092_abnormal_eye_morphology | 0.74826129 |
| 104 | MP0005666_abnormal_adipose_tissue | 0.74027164 |
| 105 | MP0005174_abnormal_tail_pigmentation | 0.73720465 |
| 106 | MP0005451_abnormal_body_composition | 0.73544673 |
| 107 | MP0001800_abnormal_humoral_immune | 0.73533855 |
| 108 | MP0000716_abnormal_immune_system | 0.72966798 |
| 109 | MP0003718_maternal_effect | 0.72721461 |
| 110 | MP0001216_abnormal_epidermal_layer | 0.71984855 |
| 111 | MP0003943_abnormal_hepatobiliary_system | 0.71568781 |
| 112 | MP0000733_abnormal_muscle_development | 0.70915469 |
| 113 | MP0000627_abnormal_mammary_gland | 0.69919362 |
| 114 | MP0003698_abnormal_male_reproductive | 0.69872961 |
| 115 | MP0009333_abnormal_splenocyte_physiolog | 0.69319059 |
| 116 | MP0003448_altered_tumor_morphology | 0.68487549 |
| 117 | MP0002233_abnormal_nose_morphology | 0.67800207 |
| 118 | MP0001188_hyperpigmentation | 0.67694982 |
| 119 | MP0005647_abnormal_sex_gland | 0.67554719 |
| 120 | MP0002429_abnormal_blood_cell | 0.67459473 |
| 121 | MP0000579_abnormal_nail_morphology | 0.67240870 |
| 122 | MP0010630_abnormal_cardiac_muscle | 0.66971878 |
| 123 | MP0000383_abnormal_hair_follicle | 0.66953629 |
| 124 | MP0003861_abnormal_nervous_system | 0.66464445 |
| 125 | MP0002697_abnormal_eye_size | 0.66078179 |
| 126 | MP0002160_abnormal_reproductive_system | 0.64967373 |
| 127 | MP0003699_abnormal_female_reproductive | 0.64467367 |
| 128 | MP0005384_cellular_phenotype | 0.64328941 |
| 129 | MP0002405_respiratory_system_inflammati | 0.63885794 |
| 130 | MP0000358_abnormal_cell_content/ | 0.63244527 |
| 131 | MP0001727_abnormal_embryo_implantation | 0.61970180 |
| 132 | MP0003950_abnormal_plasma_membrane | 0.61469332 |
| 133 | MP0005248_abnormal_Harderian_gland | 0.61464261 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 4.31949778 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.95141793 |
| 3 | Volvulus (HP:0002580) | 3.93676344 |
| 4 | Abnormality of the fingertips (HP:0001211) | 3.72404572 |
| 5 | Birth length less than 3rd percentile (HP:0003561) | 3.53664692 |
| 6 | Abnormality of chromosome stability (HP:0003220) | 3.28296720 |
| 7 | Papillary thyroid carcinoma (HP:0002895) | 3.13515769 |
| 8 | Ectopic kidney (HP:0000086) | 3.12770195 |
| 9 | Abnormality of the labia minora (HP:0012880) | 3.01415852 |
| 10 | Acute myeloid leukemia (HP:0004808) | 3.00151318 |
| 11 | Overlapping toe (HP:0001845) | 2.94696564 |
| 12 | Long eyelashes (HP:0000527) | 2.82090768 |
| 13 | Medulloblastoma (HP:0002885) | 2.79506818 |
| 14 | Facial hemangioma (HP:0000329) | 2.77893010 |
| 15 | Acanthocytosis (HP:0001927) | 2.77576924 |
| 16 | Patellar aplasia (HP:0006443) | 2.73588199 |
| 17 | Impulsivity (HP:0100710) | 2.69206243 |
| 18 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.66739972 |
| 19 | Meckel diverticulum (HP:0002245) | 2.63905683 |
| 20 | Abnormality of the preputium (HP:0100587) | 2.63491557 |
| 21 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.56538847 |
| 22 | Myelodysplasia (HP:0002863) | 2.56056192 |
| 23 | Short middle phalanx of the 5th finger (HP:0004220) | 2.54621136 |
| 24 | Neoplasm of the small intestine (HP:0100833) | 2.51384500 |
| 25 | Lip pit (HP:0100267) | 2.50696071 |
| 26 | Progressive external ophthalmoplegia (HP:0000590) | 2.50150661 |
| 27 | Abnormality of the ileum (HP:0001549) | 2.46511490 |
| 28 | Prominent nose (HP:0000448) | 2.42637096 |
| 29 | Subacute progressive viral hepatitis (HP:0006572) | 2.42067143 |
| 30 | Curly hair (HP:0002212) | 2.41459803 |
| 31 | Multiple enchondromatosis (HP:0005701) | 2.39998825 |
| 32 | Ependymoma (HP:0002888) | 2.33709167 |
| 33 | Ankyloglossia (HP:0010296) | 2.30181427 |
| 34 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 2.29749847 |
| 35 | Missing ribs (HP:0000921) | 2.28360423 |
| 36 | Supernumerary spleens (HP:0009799) | 2.26490931 |
| 37 | Colon cancer (HP:0003003) | 2.25463011 |
| 38 | Uterine leiomyosarcoma (HP:0002891) | 2.25099260 |
| 39 | Leiomyosarcoma (HP:0100243) | 2.25099260 |
| 40 | IgM deficiency (HP:0002850) | 2.22942984 |
| 41 | Neoplasm of the colon (HP:0100273) | 2.20915964 |
| 42 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.20285424 |
| 43 | Short 4th metacarpal (HP:0010044) | 2.20285424 |
| 44 | Transitional cell carcinoma of the bladder (HP:0006740) | 2.20128096 |
| 45 | Cortical dysplasia (HP:0002539) | 2.19859983 |
| 46 | Neoplasm of the oral cavity (HP:0100649) | 2.18358274 |
| 47 | Relative macrocephaly (HP:0004482) | 2.18259738 |
| 48 | Rhabdomyosarcoma (HP:0002859) | 2.17981061 |
| 49 | Deep philtrum (HP:0002002) | 2.15885628 |
| 50 | Insidious onset (HP:0003587) | 2.15643615 |
| 51 | Termporal pattern (HP:0011008) | 2.15643615 |
| 52 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.15084721 |
| 53 | Deviation of the thumb (HP:0009603) | 2.14766214 |
| 54 | Sparse lateral eyebrow (HP:0005338) | 2.14313466 |
| 55 | Uterine neoplasm (HP:0010784) | 2.13174372 |
| 56 | Sandal gap (HP:0001852) | 2.09534832 |
| 57 | Acute lymphatic leukemia (HP:0006721) | 2.09186548 |
| 58 | Small intestinal stenosis (HP:0012848) | 2.08301177 |
| 59 | Duodenal stenosis (HP:0100867) | 2.08301177 |
| 60 | Agnosia (HP:0010524) | 2.06932142 |
| 61 | Proximal placement of thumb (HP:0009623) | 2.06702235 |
| 62 | Increased nuchal translucency (HP:0010880) | 2.05842510 |
| 63 | Bladder carcinoma (HP:0002862) | 2.02987648 |
| 64 | Bladder neoplasm (HP:0009725) | 2.02987648 |
| 65 | Absent radius (HP:0003974) | 2.02374834 |
| 66 | Clubbing of toes (HP:0100760) | 2.01160722 |
| 67 | Embryonal neoplasm (HP:0002898) | 2.00481257 |
| 68 | IgA deficiency (HP:0002720) | 2.00081362 |
| 69 | Spinal cord lesions (HP:0100561) | 1.99754895 |
| 70 | Syringomyelia (HP:0003396) | 1.99754895 |
| 71 | Cafe-au-lait spot (HP:0000957) | 1.99566341 |
| 72 | Abnormality of the carotid arteries (HP:0005344) | 1.98753402 |
| 73 | Oligodactyly (HP:0012165) | 1.97425825 |
| 74 | Abnormal number of incisors (HP:0011064) | 1.97068694 |
| 75 | Cystic hygroma (HP:0000476) | 1.96112933 |
| 76 | Low anterior hairline (HP:0000294) | 1.95321236 |
| 77 | Reticulocytopenia (HP:0001896) | 1.94945192 |
| 78 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.94833034 |
| 79 | Breast hypoplasia (HP:0003187) | 1.94728172 |
| 80 | Thyroid carcinoma (HP:0002890) | 1.93678727 |
| 81 | Biliary tract neoplasm (HP:0100574) | 1.91475489 |
| 82 | Absent thumb (HP:0009777) | 1.91019886 |
| 83 | Shawl scrotum (HP:0000049) | 1.90791058 |
| 84 | Abnormality of the astrocytes (HP:0100707) | 1.90667780 |
| 85 | Astrocytoma (HP:0009592) | 1.90667780 |
| 86 | Prostate neoplasm (HP:0100787) | 1.90657133 |
| 87 | Truncal obesity (HP:0001956) | 1.90189107 |
| 88 | Abnormality of the nasal septum (HP:0000419) | 1.88600438 |
| 89 | Sloping forehead (HP:0000340) | 1.86554254 |
| 90 | Aplastic anemia (HP:0001915) | 1.85696917 |
| 91 | Capillary hemangiomas (HP:0005306) | 1.84716667 |
| 92 | Absent forearm bone (HP:0003953) | 1.84654349 |
| 93 | Aplasia involving forearm bones (HP:0009822) | 1.84654349 |
| 94 | Atresia of the external auditory canal (HP:0000413) | 1.82699008 |
| 95 | Urethral obstruction (HP:0000796) | 1.82460376 |
| 96 | Absent frontal sinuses (HP:0002688) | 1.81575553 |
| 97 | Dysmetric saccades (HP:0000641) | 1.81019722 |
| 98 | Breast carcinoma (HP:0003002) | 1.81012200 |
| 99 | Progressive muscle weakness (HP:0003323) | 1.80665936 |
| 100 | Anal stenosis (HP:0002025) | 1.80633149 |
| 101 | Asymmetry of the thorax (HP:0001555) | 1.79763064 |
| 102 | Glioma (HP:0009733) | 1.79333953 |
| 103 | Heterotopia (HP:0002282) | 1.78435052 |
| 104 | Abnormality of chromosome segregation (HP:0002916) | 1.77910762 |
| 105 | Microtia (HP:0008551) | 1.77557865 |
| 106 | Amaurosis fugax (HP:0100576) | 1.77131219 |
| 107 | Hypoplastic labia majora (HP:0000059) | 1.76759903 |
| 108 | Oligodactyly (hands) (HP:0001180) | 1.76170714 |
| 109 | Cutis marmorata (HP:0000965) | 1.75871789 |
| 110 | Viral hepatitis (HP:0006562) | 1.75700492 |
| 111 | Embryonal renal neoplasm (HP:0011794) | 1.75638044 |
| 112 | Choanal atresia (HP:0000453) | 1.75625557 |
| 113 | Abnormality of oral frenula (HP:0000190) | 1.75296635 |
| 114 | Short thumb (HP:0009778) | 1.75252839 |
| 115 | Neuroblastic tumors (HP:0004376) | 1.74443981 |
| 116 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 1.74443981 |
| 117 | Neuroblastoma (HP:0003006) | 1.74443981 |
| 118 | Primitive neuroectodermal tumor (HP:0030065) | 1.74443981 |
| 119 | Selective tooth agenesis (HP:0001592) | 1.74371319 |
| 120 | Abnormality of the duodenum (HP:0002246) | 1.73968205 |
| 121 | Neoplasm of the pancreas (HP:0002894) | 1.70558101 |
| 122 | Abnormal spermatogenesis (HP:0008669) | 1.70230969 |
| 123 | Wide nose (HP:0000445) | 1.70007396 |
| 124 | Basal cell carcinoma (HP:0002671) | 1.69552151 |
| 125 | Radioulnar synostosis (HP:0002974) | 1.69099640 |
| 126 | Trigonocephaly (HP:0000243) | 1.68573147 |
| 127 | Large earlobe (HP:0009748) | 1.68505059 |
| 128 | Abnormal lung lobation (HP:0002101) | 1.68308907 |
| 129 | Skull defect (HP:0001362) | 1.68016850 |
| 130 | Gastrointestinal carcinoma (HP:0002672) | 1.67357126 |
| 131 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.67357126 |
| 132 | Sparse scalp hair (HP:0002209) | 1.67144428 |
| 133 | Spastic diplegia (HP:0001264) | 1.67112808 |
| 134 | Midline defect of the nose (HP:0004122) | 1.66352937 |
| 135 | Neoplasm of the rectum (HP:0100743) | 1.66084593 |
| 136 | Obsessive-compulsive behavior (HP:0000722) | 1.65372086 |
| 137 | Ovarian neoplasm (HP:0100615) | 1.65354049 |
| 138 | Rib fusion (HP:0000902) | 1.63943325 |
| 139 | Pelvic girdle muscle weakness (HP:0003749) | 1.63485923 |
| 140 | Neoplasm of striated muscle (HP:0009728) | 1.63314917 |
| 141 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.62634265 |
| 142 | High pitched voice (HP:0001620) | 1.61800664 |
| 143 | Bone marrow hypocellularity (HP:0005528) | 1.61479616 |
| 144 | Broad thumb (HP:0011304) | 1.60257348 |
| 145 | Tracheoesophageal fistula (HP:0002575) | 1.60084830 |
| 146 | Abnormality of the labia majora (HP:0012881) | 1.60068863 |
| 147 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.58982441 |
| 148 | Abnormality of the incisor (HP:0000676) | 1.57816901 |
| 149 | Supernumerary ribs (HP:0005815) | 1.56285799 |
| 150 | T lymphocytopenia (HP:0005403) | 1.55388987 |
| 151 | Vertebral arch anomaly (HP:0008438) | 1.54416645 |
| 152 | Arteriovenous malformation (HP:0100026) | 1.54365259 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 5.09816702 |
| 2 | CDK12 | 4.81780377 |
| 3 | PLK4 | 2.98154096 |
| 4 | NEK2 | 2.80855756 |
| 5 | LATS1 | 2.75328510 |
| 6 | SRPK1 | 2.46782435 |
| 7 | TTK | 2.37125713 |
| 8 | WEE1 | 2.35764950 |
| 9 | ACVR1B | 2.24633753 |
| 10 | STK3 | 2.16250368 |
| 11 | PBK | 2.11136849 |
| 12 | TAF1 | 2.09725439 |
| 13 | EIF2AK1 | 1.97707183 |
| 14 | BRSK2 | 1.93350886 |
| 15 | CHEK2 | 1.90833727 |
| 16 | STK10 | 1.87994715 |
| 17 | BRD4 | 1.85773640 |
| 18 | PLK3 | 1.83141809 |
| 19 | RPS6KA4 | 1.78072471 |
| 20 | CHEK1 | 1.74292061 |
| 21 | ATR | 1.73545568 |
| 22 | MKNK2 | 1.71914851 |
| 23 | MKNK1 | 1.69088641 |
| 24 | PLK1 | 1.64266168 |
| 25 | EEF2K | 1.62979368 |
| 26 | STK38L | 1.60765119 |
| 27 | AURKB | 1.55716176 |
| 28 | ATM | 1.48133311 |
| 29 | CDK7 | 1.43303668 |
| 30 | RPS6KB2 | 1.39697033 |
| 31 | STK4 | 1.36380507 |
| 32 | CDK4 | 1.35730634 |
| 33 | MELK | 1.30912133 |
| 34 | CDK6 | 1.28277824 |
| 35 | LATS2 | 1.28181442 |
| 36 | FRK | 1.28084679 |
| 37 | NUAK1 | 1.25527105 |
| 38 | PNCK | 1.24863940 |
| 39 | DYRK3 | 1.24360567 |
| 40 | VRK1 | 1.22520079 |
| 41 | ALK | 1.21941923 |
| 42 | PRPF4B | 1.19478243 |
| 43 | CDK8 | 1.16737984 |
| 44 | CDK9 | 1.15847513 |
| 45 | SMG1 | 1.11640443 |
| 46 | * CDK2 | 1.10763670 |
| 47 | PIM1 | 1.10473867 |
| 48 | TSSK6 | 1.04406259 |
| 49 | YES1 | 1.03653676 |
| 50 | MAP3K8 | 0.98989575 |
| 51 | BUB1 | 0.97292775 |
| 52 | TXK | 0.95906640 |
| 53 | NEK9 | 0.94504564 |
| 54 | MAP3K2 | 0.93416072 |
| 55 | CAMK1D | 0.91973006 |
| 56 | MAP3K14 | 0.89088329 |
| 57 | CDK1 | 0.88416306 |
| 58 | AKT3 | 0.86902458 |
| 59 | MAP3K6 | 0.86532561 |
| 60 | MTOR | 0.83399509 |
| 61 | CHUK | 0.82783295 |
| 62 | EIF2AK3 | 0.82373605 |
| 63 | ERBB3 | 0.82272017 |
| 64 | KSR2 | 0.79979192 |
| 65 | JAK3 | 0.79772939 |
| 66 | PASK | 0.78788105 |
| 67 | MAP4K1 | 0.78219932 |
| 68 | MAP3K10 | 0.77935049 |
| 69 | ZAK | 0.76508562 |
| 70 | MARK3 | 0.72925122 |
| 71 | PDGFRA | 0.68823827 |
| 72 | STK24 | 0.68486916 |
| 73 | BMPR2 | 0.68288685 |
| 74 | MAPK14 | 0.67653835 |
| 75 | FGFR3 | 0.66512719 |
| 76 | CDK3 | 0.64080562 |
| 77 | CAMK1G | 0.63755076 |
| 78 | NEK6 | 0.63722451 |
| 79 | TEC | 0.63065467 |
| 80 | CSNK1E | 0.60802022 |
| 81 | MST1R | 0.59510194 |
| 82 | TAOK3 | 0.57725843 |
| 83 | RPS6KA5 | 0.57602074 |
| 84 | MET | 0.57289210 |
| 85 | TGFBR1 | 0.56686933 |
| 86 | TRPM7 | 0.56008569 |
| 87 | ERBB4 | 0.55999257 |
| 88 | BRSK1 | 0.55873277 |
| 89 | FGFR1 | 0.55259466 |
| 90 | PAK4 | 0.54599522 |
| 91 | CSNK1D | 0.54506254 |
| 92 | DMPK | 0.53143965 |
| 93 | KSR1 | 0.52605149 |
| 94 | NLK | 0.52542279 |
| 95 | CSNK2A2 | 0.51405661 |
| 96 | PRKDC | 0.51349113 |
| 97 | RPS6KB1 | 0.50446104 |
| 98 | EPHA2 | 0.49559655 |
| 99 | TLK1 | 0.49018892 |
| 100 | MAPK10 | 0.48933381 |
| 101 | GSK3B | 0.48099822 |
| 102 | TAOK1 | 0.48062781 |
| 103 | PDGFRB | 0.47895725 |
| 104 | AKT1 | 0.46538563 |
| 105 | PLK2 | 0.46160425 |
| 106 | CLK1 | 0.44352870 |
| 107 | MAP3K9 | 0.43586850 |
| 108 | SCYL2 | 0.39241486 |
| 109 | FGFR4 | 0.38419994 |
| 110 | MAPK1 | 0.37183316 |
| 111 | MAP3K5 | 0.36083148 |
| 112 | MST4 | 0.34898812 |
| 113 | AURKA | 0.34652849 |
| 114 | CSNK2A1 | 0.32770790 |
| 115 | PDK2 | 0.32267899 |
| 116 | BMX | 0.31488399 |
| 117 | RAF1 | 0.31040086 |
| 118 | BCR | 0.30259856 |
| 119 | HIPK2 | 0.29934932 |
| 120 | EGFR | 0.29300564 |
| 121 | WNK1 | 0.29131046 |
| 122 | PAK2 | 0.28872044 |
| 123 | TTN | 0.28144633 |
| 124 | EIF2AK2 | 0.26913390 |
| 125 | IRAK2 | 0.26832116 |
| 126 | SGK3 | 0.25647253 |
| 127 | ITK | 0.23109110 |
| 128 | NEK1 | 0.23013002 |
| 129 | FGFR2 | 0.21591879 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.04336691 |
| 2 | Cell cycle_Homo sapiens_hsa04110 | 2.86358679 |
| 3 | RNA transport_Homo sapiens_hsa03013 | 2.84857688 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.65969293 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 2.60755887 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.55417962 |
| 7 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.41054714 |
| 8 | RNA degradation_Homo sapiens_hsa03018 | 2.40994830 |
| 9 | Basal transcription factors_Homo sapiens_hsa03022 | 2.38907870 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.30408008 |
| 11 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.23950519 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.93017972 |
| 13 | RNA polymerase_Homo sapiens_hsa03020 | 1.91297274 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 1.78355387 |
| 15 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.75129842 |
| 16 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.69851202 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.67534284 |
| 18 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.45983914 |
| 19 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.45627267 |
| 20 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.43649020 |
| 21 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.37940011 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.37787530 |
| 23 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.24399935 |
| 24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.23670145 |
| 25 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.22157605 |
| 26 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.20328490 |
| 27 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.19964334 |
| 28 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.19575643 |
| 29 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.17416426 |
| 30 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.14756002 |
| 31 | Colorectal cancer_Homo sapiens_hsa05210 | 1.13761236 |
| 32 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.12351011 |
| 33 | HTLV-I infection_Homo sapiens_hsa05166 | 1.11150849 |
| 34 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.10984210 |
| 35 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.09409179 |
| 36 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.08031007 |
| 37 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.07102076 |
| 38 | Adherens junction_Homo sapiens_hsa04520 | 1.05424731 |
| 39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.05393818 |
| 40 | Hepatitis B_Homo sapiens_hsa05161 | 1.01302074 |
| 41 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.99786045 |
| 42 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.97373337 |
| 43 | Prostate cancer_Homo sapiens_hsa05215 | 0.96946488 |
| 44 | Measles_Homo sapiens_hsa05162 | 0.95462032 |
| 45 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.93080998 |
| 46 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.92425296 |
| 47 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.90152326 |
| 48 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.86957380 |
| 49 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.86059119 |
| 50 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.85691658 |
| 51 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.85615737 |
| 52 | Thyroid cancer_Homo sapiens_hsa05216 | 0.83583569 |
| 53 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.82091909 |
| 54 | Influenza A_Homo sapiens_hsa05164 | 0.78421128 |
| 55 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.76449136 |
| 56 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.75918843 |
| 57 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.74352544 |
| 58 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.74187109 |
| 59 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.73631758 |
| 60 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.73572323 |
| 61 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.72870650 |
| 62 | Viral myocarditis_Homo sapiens_hsa05416 | 0.72723888 |
| 63 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.72306636 |
| 64 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.72265793 |
| 65 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.70958860 |
| 66 | Apoptosis_Homo sapiens_hsa04210 | 0.70407160 |
| 67 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.70207124 |
| 68 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.69928949 |
| 69 | Endometrial cancer_Homo sapiens_hsa05213 | 0.69329178 |
| 70 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.69078978 |
| 71 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.69056629 |
| 72 | Purine metabolism_Homo sapiens_hsa00230 | 0.68589758 |
| 73 | Bladder cancer_Homo sapiens_hsa05219 | 0.68557304 |
| 74 | Pathways in cancer_Homo sapiens_hsa05200 | 0.66630339 |
| 75 | Allograft rejection_Homo sapiens_hsa05330 | 0.66532544 |
| 76 | Ribosome_Homo sapiens_hsa03010 | 0.66470500 |
| 77 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.65487191 |
| 78 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.65274599 |
| 79 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.63833534 |
| 80 | Alcoholism_Homo sapiens_hsa05034 | 0.62487972 |
| 81 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.61928784 |
| 82 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.61763138 |
| 83 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.60251391 |
| 84 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.60067889 |
| 85 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.59808593 |
| 86 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.59185776 |
| 87 | Leishmaniasis_Homo sapiens_hsa05140 | 0.57237637 |
| 88 | Lysine degradation_Homo sapiens_hsa00310 | 0.56204953 |
| 89 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.55739363 |
| 90 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.55353997 |
| 91 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.55185858 |
| 92 | Shigellosis_Homo sapiens_hsa05131 | 0.54560032 |
| 93 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.53753652 |
| 94 | Melanoma_Homo sapiens_hsa05218 | 0.52719244 |
| 95 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.52143470 |
| 96 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.50265085 |
| 97 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.49362991 |
| 98 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.48766465 |
| 99 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.48732498 |
| 100 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.48659110 |
| 101 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.48496449 |
| 102 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.48413393 |
| 103 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.48059802 |
| 104 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.47413684 |
| 105 | Glioma_Homo sapiens_hsa05214 | 0.47357601 |
| 106 | Protein export_Homo sapiens_hsa03060 | 0.46630872 |
| 107 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.46569104 |
| 108 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.46021967 |
| 109 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.46013363 |
| 110 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.45853349 |
| 111 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.44709543 |
| 112 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.44389491 |
| 113 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43729543 |
| 114 | Asthma_Homo sapiens_hsa05310 | 0.43332513 |
| 115 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.42841221 |
| 116 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.42679311 |
| 117 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.42388344 |
| 118 | Legionellosis_Homo sapiens_hsa05134 | 0.41763266 |
| 119 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.40250324 |
| 120 | Hepatitis C_Homo sapiens_hsa05160 | 0.39352847 |
| 121 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.39173827 |
| 122 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39035492 |
| 123 | Tight junction_Homo sapiens_hsa04530 | 0.38253898 |
| 124 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.36578363 |
| 125 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.35773372 |
| 126 | Circadian rhythm_Homo sapiens_hsa04710 | 0.35646600 |

