RBM28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.18517012
2nuclear pore complex assembly (GO:0051292)5.15503703
3mitotic metaphase plate congression (GO:0007080)4.83972267
4protein localization to kinetochore (GO:0034501)4.65513457
5pore complex assembly (GO:0046931)4.45671670
6metaphase plate congression (GO:0051310)4.36443816
7IMP biosynthetic process (GO:0006188)4.20036790
8DNA unwinding involved in DNA replication (GO:0006268)4.12382488
9DNA replication initiation (GO:0006270)4.06608253
10replication fork processing (GO:0031297)4.06575571
11nucleobase biosynthetic process (GO:0046112)4.04005221
12mitotic nuclear envelope disassembly (GO:0007077)4.03099555
13protein localization to chromosome, centromeric region (GO:0071459)4.02198207
14establishment of chromosome localization (GO:0051303)3.82910756
15DNA replication checkpoint (GO:0000076)3.80194894
16ribosome assembly (GO:0042255)3.79039993
17ribosome biogenesis (GO:0042254)3.77360032
18mitotic sister chromatid cohesion (GO:0007064)3.73445807
19regulation of spindle organization (GO:0090224)3.73210066
20nuclear envelope disassembly (GO:0051081)3.67046196
21membrane disassembly (GO:0030397)3.67046196
22purine nucleobase biosynthetic process (GO:0009113)3.65956677
23regulation of mitotic spindle organization (GO:0060236)3.64883185
24IMP metabolic process (GO:0046040)3.62821561
25protein K6-linked ubiquitination (GO:0085020)3.54990127
26DNA geometric change (GO:0032392)3.52396539
27DNA strand elongation involved in DNA replication (GO:0006271)3.50499816
28DNA duplex unwinding (GO:0032508)3.50436311
29positive regulation of chromosome segregation (GO:0051984)3.50148327
30regulation of centriole replication (GO:0046599)3.49325614
31kinetochore organization (GO:0051383)3.47266640
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.45908375
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41763490
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.41386342
35regulation of translation, ncRNA-mediated (GO:0045974)3.41386342
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41386342
37DNA strand elongation (GO:0022616)3.39560147
38chromatin remodeling at centromere (GO:0031055)3.38753843
39regulation of helicase activity (GO:0051095)3.38194565
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.38113777
41CENP-A containing nucleosome assembly (GO:0034080)3.35415267
42recombinational repair (GO:0000725)3.34235316
43double-strand break repair via homologous recombination (GO:0000724)3.34099980
44sister chromatid segregation (GO:0000819)3.30794470
45regulation of centrosome cycle (GO:0046605)3.25531013
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25298350
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25298350
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.25298350
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23261364
50mitotic sister chromatid segregation (GO:0000070)3.22767260
51snRNA processing (GO:0016180)3.22535669
52pseudouridine synthesis (GO:0001522)3.22197585
53DNA double-strand break processing (GO:0000729)3.21366011
54response to pheromone (GO:0019236)3.16889099
55meiotic chromosome segregation (GO:0045132)3.16653679
56DNA replication-independent nucleosome organization (GO:0034724)3.16439318
57DNA replication-independent nucleosome assembly (GO:0006336)3.16439318
58histone exchange (GO:0043486)3.13678911
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12124179
60folic acid-containing compound biosynthetic process (GO:0009396)3.09734045
61telomere maintenance via semi-conservative replication (GO:0032201)3.09657775
62maturation of SSU-rRNA (GO:0030490)3.09498541
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08538750
64pre-miRNA processing (GO:0031054)3.07865961
65mitotic recombination (GO:0006312)3.06700917
66DNA replication-dependent nucleosome assembly (GO:0006335)3.06248031
67DNA replication-dependent nucleosome organization (GO:0034723)3.06248031
68telomere maintenance via recombination (GO:0000722)3.06117043
69ribonucleoprotein complex biogenesis (GO:0022613)3.03816763
70termination of RNA polymerase I transcription (GO:0006363)3.02609789
71kinetochore assembly (GO:0051382)3.01062207
72synapsis (GO:0007129)3.00846786
73snRNA metabolic process (GO:0016073)3.00087508
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98989897
75regulation of mitotic spindle checkpoint (GO:1903504)2.98989897
76centriole replication (GO:0007099)2.98784761
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97096264
78regulation of histone H3-K9 methylation (GO:0051570)2.96739859
79mitochondrial RNA metabolic process (GO:0000959)2.96130709
80protein localization to chromosome (GO:0034502)2.95072787
81mismatch repair (GO:0006298)2.94180315
82spindle checkpoint (GO:0031577)2.91959408
83transcription elongation from RNA polymerase I promoter (GO:0006362)2.90664420
84regulation of DNA endoreduplication (GO:0032875)2.89355119
85paraxial mesoderm development (GO:0048339)2.89015427
86heterochromatin organization (GO:0070828)2.88445141
87telomere maintenance via telomere lengthening (GO:0010833)2.88410419
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88130348
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.88130348
90DNA conformation change (GO:0071103)2.87874563
91negative regulation of histone methylation (GO:0031061)2.87730520
92histone H2A acetylation (GO:0043968)2.87600858
93reciprocal DNA recombination (GO:0035825)2.86099097
94reciprocal meiotic recombination (GO:0007131)2.86099097
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85561154
96regulation of chromosome segregation (GO:0051983)2.84908157
97behavioral response to nicotine (GO:0035095)2.84640374
98regulation of posttranscriptional gene silencing (GO:0060147)2.84533623
99regulation of gene silencing by miRNA (GO:0060964)2.84533623
100regulation of gene silencing by RNA (GO:0060966)2.84533623
101telomere maintenance via telomerase (GO:0007004)2.84085862
102formation of translation preinitiation complex (GO:0001731)2.83874291
103ATP-dependent chromatin remodeling (GO:0043044)2.83847581
104regulation of centrosome duplication (GO:0010824)2.83395034
105nuclear envelope organization (GO:0006998)2.82817487
106mRNA transport (GO:0051028)2.81258218
107postreplication repair (GO:0006301)2.81197145
108regulation of RNA export from nucleus (GO:0046831)2.80300682
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79475407
110maturation of 5.8S rRNA (GO:0000460)2.79409877
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79368159
112resolution of meiotic recombination intermediates (GO:0000712)2.78618893
113telomere organization (GO:0032200)2.78365683
114telomere maintenance (GO:0000723)2.78353080
115chromatin assembly or disassembly (GO:0006333)2.78289524
116regulation of hippo signaling (GO:0035330)2.78032308
117attachment of spindle microtubules to kinetochore (GO:0008608)2.77893527
118mitotic spindle checkpoint (GO:0071174)2.77866663
119mitotic chromosome condensation (GO:0007076)2.77228358
120RNA splicing, via transesterification reactions (GO:0000375)2.77034234
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.76546266
122dosage compensation (GO:0007549)2.76163860
123peptidyl-histidine modification (GO:0018202)2.75175446
124non-recombinational repair (GO:0000726)2.72416658
125double-strand break repair via nonhomologous end joining (GO:0006303)2.72416658
126respiratory chain complex IV assembly (GO:0008535)2.71671451
127monoubiquitinated protein deubiquitination (GO:0035520)2.67332752
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.65326610
129NADH dehydrogenase complex assembly (GO:0010257)2.65326610
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65326610
131translesion synthesis (GO:0019985)2.64471904
132prenylation (GO:0097354)2.62890852
133protein prenylation (GO:0018342)2.62890852
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62120967
135centrosome organization (GO:0051297)2.61273150
136rRNA catabolic process (GO:0016075)2.56333290
137microtubule anchoring (GO:0034453)2.54856930
138DNA recombination (GO:0006310)2.54821870
139ncRNA catabolic process (GO:0034661)2.53889308
140microtubule organizing center organization (GO:0031023)2.53862746
141double-strand break repair (GO:0006302)2.51621488
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.51307730
143mitochondrial respiratory chain complex assembly (GO:0033108)2.50505662
144intra-S DNA damage checkpoint (GO:0031573)2.49614929
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48200956
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48102977
147neural tube formation (GO:0001841)2.46147890
148sister chromatid cohesion (GO:0007062)2.45661881
149transcription from mitochondrial promoter (GO:0006390)2.42690170
150DNA-dependent DNA replication (GO:0006261)2.41971836
151DNA strand renaturation (GO:0000733)2.41544267
152somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41037684
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41037684
154isotype switching (GO:0045190)2.41037684
155protein complex biogenesis (GO:0070271)2.40984996
156DNA catabolic process, exonucleolytic (GO:0000738)2.40817935
157methionine biosynthetic process (GO:0009086)2.39306614
158kynurenine metabolic process (GO:0070189)2.39266654
159viral mRNA export from host cell nucleus (GO:0046784)2.34152207
160somatic recombination of immunoglobulin gene segments (GO:0016447)2.33992695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.79134874
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.36627827
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.03915347
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24394142
5ZNF274_21170338_ChIP-Seq_K562_Hela3.21954859
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.11217102
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98429028
8VDR_22108803_ChIP-Seq_LS180_Human2.74341973
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.71482025
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.70726028
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65773239
12AR_21909140_ChIP-Seq_LNCAP_Human2.53452226
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53061963
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.46471716
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.42138357
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23888326
17FUS_26573619_Chip-Seq_HEK293_Human2.19089573
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18890528
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.15254585
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14687155
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11774776
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10515978
23* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10502635
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07164524
25GBX2_23144817_ChIP-Seq_PC3_Human2.03930313
26* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03839097
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02182346
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02104770
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.02010209
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00107418
31E2F7_22180533_ChIP-Seq_HELA_Human11.2691292
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90975618
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.90633558
34XRN2_22483619_ChIP-Seq_HELA_Human1.90197511
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.86806415
36IGF1R_20145208_ChIP-Seq_DFB_Human1.86794704
37* VDR_23849224_ChIP-Seq_CD4+_Human1.86608539
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.85473925
39TAF15_26573619_Chip-Seq_HEK293_Human1.81105313
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79187395
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74450458
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74398171
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74341394
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74158199
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73985214
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71790542
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68982357
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63271250
49* CIITA_25753668_ChIP-Seq_RAJI_Human1.63153338
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.62921543
51TTF2_22483619_ChIP-Seq_HELA_Human1.62052860
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60031471
53MYC_22102868_ChIP-Seq_BL_Human1.60025621
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59543375
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58737928
56P300_19829295_ChIP-Seq_ESCs_Human1.58497985
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57607310
58ER_23166858_ChIP-Seq_MCF-7_Human1.54261413
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48517479
60KDM5A_27292631_Chip-Seq_BREAST_Human1.45835358
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45341798
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41858872
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40975207
64EZH2_22144423_ChIP-Seq_EOC_Human1.40562817
65* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39902458
66* GABP_19822575_ChIP-Seq_HepG2_Human1.39575872
67DCP1A_22483619_ChIP-Seq_HELA_Human1.38972247
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36863422
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35278127
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34469856
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33827102
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32352483
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32114046
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32079820
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29061475
76* STAT3_23295773_ChIP-Seq_U87_Human1.28826720
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27645107
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25765594
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24652048
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24548571
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21181531
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20980219
83CBP_20019798_ChIP-Seq_JUKART_Human1.17583458
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17583458
85IRF1_19129219_ChIP-ChIP_H3396_Human1.17386951
86TCF4_23295773_ChIP-Seq_U87_Human1.17093098
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15506267
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15498454
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12944010
90SMAD4_21799915_ChIP-Seq_A2780_Human1.12352566
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11912527
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11766554
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11629065
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11354948
95TP53_22573176_ChIP-Seq_HFKS_Human1.10794076
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10194091
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10194091
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10007906
99TFEB_21752829_ChIP-Seq_HELA_Human1.09305132
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06841732
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05384159
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03190907
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01886188
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01366402
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01366402
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01366402
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01212882
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.00855934
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98965514
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.98010650
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97799225
112AR_21572438_ChIP-Seq_LNCaP_Human0.95806752
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.95487860
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95336705
115AR_25329375_ChIP-Seq_VCAP_Human0.95302063
116BCAT_22108803_ChIP-Seq_LS180_Human0.94665787
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.93840735
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92371560
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92235287
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92113592
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91936029
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.91813881
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91805679
124TCF4_22108803_ChIP-Seq_LS180_Human0.91757514
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.91523417
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91517507
127SOX9_26525672_Chip-Seq_HEART_Mouse0.89576979
128MYC_18940864_ChIP-ChIP_HL60_Human0.89042678
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87492863
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.86489860
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86464176
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86333227
133EWS_26573619_Chip-Seq_HEK293_Human0.86089998
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.86051992
135* RNF2_27304074_Chip-Seq_NSC_Mouse0.85570084
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85116118
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84932704
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84668428
139KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83996844
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83635059
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83298635
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78734297
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77511068
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.77502572
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.76615891
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76598313
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75716109
148GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75435539
149SPI1_23547873_ChIP-Seq_NB4_Human0.74963524
150CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74770837
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.74766303
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74412596
153MYB_26560356_Chip-Seq_TH1_Human0.73852720
154NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73523060
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73137687
156FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73047561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.29492276
2MP0010094_abnormal_chromosome_stability4.25549830
3MP0003111_abnormal_nucleus_morphology4.24245201
4MP0008057_abnormal_DNA_replication4.15974546
5MP0003077_abnormal_cell_cycle3.50899018
6MP0004957_abnormal_blastocyst_morpholog3.34603761
7MP0008058_abnormal_DNA_repair3.24606644
8MP0008007_abnormal_cellular_replicative2.97398998
9MP0002396_abnormal_hematopoietic_system2.44318551
10MP0010307_abnormal_tumor_latency2.41886322
11MP0003123_paternal_imprinting2.22583411
12MP0008877_abnormal_DNA_methylation2.15385673
13MP0005670_abnormal_white_adipose2.02407187
14MP0008932_abnormal_embryonic_tissue2.01359789
15MP0003136_yellow_coat_color1.99855401
16MP0001730_embryonic_growth_arrest1.99785308
17MP0000350_abnormal_cell_proliferation1.97826575
18MP0003786_premature_aging1.90752079
19MP0000372_irregular_coat_pigmentation1.87906173
20MP0003646_muscle_fatigue1.77703617
21MP0009697_abnormal_copulation1.76856533
22MP0005380_embryogenesis_phenotype1.73121800
23MP0001672_abnormal_embryogenesis/_devel1.73121800
24MP0010352_gastrointestinal_tract_polyps1.62876961
25MP0003121_genomic_imprinting1.60991711
26MP0001293_anophthalmia1.60161163
27MP0005171_absent_coat_pigmentation1.58300802
28MP0003195_calcinosis1.57947605
29MP0000569_abnormal_digit_pigmentation1.55771459
30MP0004197_abnormal_fetal_growth/weight/1.53775539
31MP0003984_embryonic_growth_retardation1.52522517
32MP0000631_abnormal_neuroendocrine_gland1.49748980
33MP0002088_abnormal_embryonic_growth/wei1.48499290
34MP0004147_increased_porphyrin_level1.48057208
35MP0002085_abnormal_embryonic_tissue1.46317568
36MP0002084_abnormal_developmental_patter1.43922281
37MP0005551_abnormal_eye_electrophysiolog1.43772028
38MP0006072_abnormal_retinal_apoptosis1.40459761
39MP0004808_abnormal_hematopoietic_stem1.39412619
40MP0002234_abnormal_pharynx_morphology1.38401123
41MP0005253_abnormal_eye_physiology1.37420967
42MP0001697_abnormal_embryo_size1.36140657
43MP0002102_abnormal_ear_morphology1.35419139
44MP0008438_abnormal_cutaneous_collagen1.32796675
45MP0000490_abnormal_crypts_of1.32379186
46MP0009046_muscle_twitch1.31588854
47MP0002095_abnormal_skin_pigmentation1.31487400
48MP0005076_abnormal_cell_differentiation1.31347371
49MP0003941_abnormal_skin_development1.30687940
50MP0002086_abnormal_extraembryonic_tissu1.28814969
51MP0003950_abnormal_plasma_membrane1.28383408
52MP0002080_prenatal_lethality1.27799012
53MP0003567_abnormal_fetal_cardiomyocyte1.25848299
54MP0003763_abnormal_thymus_physiology1.23527069
55MP0003937_abnormal_limbs/digits/tail_de1.23232547
56MP0002736_abnormal_nociception_after1.19789931
57MP0002638_abnormal_pupillary_reflex1.19318728
58MP0006292_abnormal_olfactory_placode1.18471961
59MP0001485_abnormal_pinna_reflex1.18377405
60MP0003787_abnormal_imprinting1.16018841
61MP0002210_abnormal_sex_determination1.15799845
62MP0003718_maternal_effect1.12810825
63MP0000313_abnormal_cell_death1.12725314
64MP0004885_abnormal_endolymph1.10970598
65MP0000427_abnormal_hair_cycle1.09444537
66MP0003890_abnormal_embryonic-extraembry1.09127617
67MP0005187_abnormal_penis_morphology1.08374871
68MP0004043_abnormal_pH_regulation1.07124218
69MP0005645_abnormal_hypothalamus_physiol1.06449466
70MP0002019_abnormal_tumor_incidence1.04313286
71MP0006035_abnormal_mitochondrial_morpho1.04200362
72MP0000383_abnormal_hair_follicle1.03749036
73MP0008872_abnormal_physiological_respon1.03571307
74MP0009703_decreased_birth_body1.02440838
75MP0001968_abnormal_touch/_nociception1.00799565
76MP0003566_abnormal_cell_adhesion1.00348853
77MP0009672_abnormal_birth_weight0.99584314
78MP0000733_abnormal_muscle_development0.99543022
79MP0000703_abnormal_thymus_morphology0.99185356
80MP0003698_abnormal_male_reproductive0.97920625
81MP0000647_abnormal_sebaceous_gland0.97260277
82MP0000432_abnormal_head_morphology0.96398720
83MP0001529_abnormal_vocalization0.95090958
84MP0001986_abnormal_taste_sensitivity0.93687385
85MP0000566_synostosis0.93250722
86MP0005391_vision/eye_phenotype0.91188132
87MP0005666_abnormal_adipose_tissue0.91176185
88MP0005503_abnormal_tendon_morphology0.90687582
89MP0001661_extended_life_span0.90683870
90MP0005646_abnormal_pituitary_gland0.90457193
91MP0002233_abnormal_nose_morphology0.89919395
92MP0002111_abnormal_tail_morphology0.89544036
93MP0001929_abnormal_gametogenesis0.89317247
94MP0001145_abnormal_male_reproductive0.89102088
95MP0001324_abnormal_eye_pigmentation0.87907861
96MP0002751_abnormal_autonomic_nervous0.87296786
97MP0000049_abnormal_middle_ear0.87082645
98MP0005023_abnormal_wound_healing0.86592524
99MP0000428_abnormal_craniofacial_morphol0.86167071
100MP0001984_abnormal_olfaction0.85299294
101MP0002837_dystrophic_cardiac_calcinosis0.84675532
102MP0002092_abnormal_eye_morphology0.84410122
103MP0004215_abnormal_myocardial_fiber0.83923196
104MP0002398_abnormal_bone_marrow0.82316691
105MP0003861_abnormal_nervous_system0.82297054
106MP0008961_abnormal_basal_metabolism0.81801298
107MP0009333_abnormal_splenocyte_physiolog0.81118799
108MP0000015_abnormal_ear_pigmentation0.81092632
109MP0003755_abnormal_palate_morphology0.80913338
110MP0006276_abnormal_autonomic_nervous0.80426434
111MP0002075_abnormal_coat/hair_pigmentati0.80190152
112MP0005408_hypopigmentation0.79942349
113MP0000371_diluted_coat_color0.79694490
114MP0008789_abnormal_olfactory_epithelium0.79633573
115MP0001119_abnormal_female_reproductive0.79075573
116MP0002557_abnormal_social/conspecific_i0.78971300
117MP0004185_abnormal_adipocyte_glucose0.78494492
118MP0003115_abnormal_respiratory_system0.78066158
119MP0001286_abnormal_eye_development0.77919689
120MP0003943_abnormal_hepatobiliary_system0.77894099
121MP0004145_abnormal_muscle_electrophysio0.77633028
122MP0002938_white_spotting0.77501783
123MP0005621_abnormal_cell_physiology0.77067339
124MP0002006_tumorigenesis0.76904788
125MP0004142_abnormal_muscle_tone0.76594295
126MP0003705_abnormal_hypodermis_morpholog0.76519462
127MP0005075_abnormal_melanosome_morpholog0.76195500
128MP0000653_abnormal_sex_gland0.75813530
129MP0002009_preneoplasia0.75568402
130MP0005395_other_phenotype0.74917850
131MP0002132_abnormal_respiratory_system0.73273760
132MP0003935_abnormal_craniofacial_develop0.72475647
133MP0001545_abnormal_hematopoietic_system0.72472674
134MP0005397_hematopoietic_system_phenotyp0.72472674
135MP0004133_heterotaxia0.72419584
136MP0005174_abnormal_tail_pigmentation0.72005276
137MP0008260_abnormal_autophagy0.71085726
138MP0002160_abnormal_reproductive_system0.70792667
139MP0005384_cellular_phenotype0.69852987
140MP0002925_abnormal_cardiovascular_devel0.68739287
141MP0008995_early_reproductive_senescence0.68539338
142MP0000858_altered_metastatic_potential0.67041541
143MP0003448_altered_tumor_morphology0.67012556
144MP0003119_abnormal_digestive_system0.66708989
145MP0002697_abnormal_eye_size0.66618735
146MP0005389_reproductive_system_phenotype0.65571852
147MP0000689_abnormal_spleen_morphology0.65182149
148MP0002722_abnormal_immune_system0.64943752
149MP0000750_abnormal_muscle_regeneration0.64129530
150MP0003938_abnormal_ear_development0.63385003
151MP0010030_abnormal_orbit_morphology0.63350156
152MP0001186_pigmentation_phenotype0.62206442

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.12215986
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.11960601
3Birth length less than 3rd percentile (HP:0003561)4.27909181
4Pancreatic cysts (HP:0001737)3.56247112
5Abnormality of chromosome stability (HP:0003220)3.29051726
6Duplicated collecting system (HP:0000081)3.26476732
7Pancreatic fibrosis (HP:0100732)3.17997602
8Medulloblastoma (HP:0002885)3.15646886
9Meckel diverticulum (HP:0002245)3.01410105
10Ectopic kidney (HP:0000086)3.00164347
11Congenital stationary night blindness (HP:0007642)2.96215005
12Molar tooth sign on MRI (HP:0002419)2.94826094
13Abnormality of midbrain morphology (HP:0002418)2.94826094
14Abnormality of the renal collecting system (HP:0004742)2.93980136
15True hermaphroditism (HP:0010459)2.90323817
16Breast hypoplasia (HP:0003187)2.88938303
17Ependymoma (HP:0002888)2.88390377
18Abnormality of the renal cortex (HP:0011035)2.87519810
19Abnormality of the ileum (HP:0001549)2.86294740
20Nephronophthisis (HP:0000090)2.82399854
21Selective tooth agenesis (HP:0001592)2.77787392
22Hyperventilation (HP:0002883)2.72385450
23Supernumerary spleens (HP:0009799)2.68543807
24Impulsivity (HP:0100710)2.67895853
25Rhabdomyosarcoma (HP:0002859)2.67822830
26Abnormality of the preputium (HP:0100587)2.67556290
27Abnormality of the labia minora (HP:0012880)2.65270911
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.63478544
29Abnormality of the renal medulla (HP:0100957)2.59969023
30Patellar aplasia (HP:0006443)2.55381443
31Astrocytoma (HP:0009592)2.53443743
32Abnormality of the astrocytes (HP:0100707)2.53443743
33Glioma (HP:0009733)2.49708793
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46707394
35Abnormality of alanine metabolism (HP:0010916)2.46707394
36Hyperalaninemia (HP:0003348)2.46707394
37Volvulus (HP:0002580)2.41435349
38Abnormal number of incisors (HP:0011064)2.41399789
39Premature graying of hair (HP:0002216)2.40421573
40Agnosia (HP:0010524)2.40264997
41Aplasia/Hypoplasia of the patella (HP:0006498)2.39608210
42Spinal cord lesions (HP:0100561)2.39176986
43Syringomyelia (HP:0003396)2.39176986
44Protruding tongue (HP:0010808)2.36016872
45Hypoplasia of the pons (HP:0012110)2.32752918
46Absent radius (HP:0003974)2.32145273
47Myelodysplasia (HP:0002863)2.31696127
48Intestinal atresia (HP:0011100)2.29921349
49Small intestinal stenosis (HP:0012848)2.29501048
50Duodenal stenosis (HP:0100867)2.29501048
51Sloping forehead (HP:0000340)2.29088239
52Neoplasm of the oral cavity (HP:0100649)2.28987531
53Medial flaring of the eyebrow (HP:0010747)2.28654371
54Deviation of the thumb (HP:0009603)2.28364834
55Abnormality of DNA repair (HP:0003254)2.28001659
56Facial cleft (HP:0002006)2.27351837
57Neoplasm of striated muscle (HP:0009728)2.25465955
58Gaze-evoked nystagmus (HP:0000640)2.24625559
59Proximal placement of thumb (HP:0009623)2.23306313
60Renal cortical cysts (HP:0000803)2.21848618
61Reticulocytopenia (HP:0001896)2.20488081
62Aplasia involving forearm bones (HP:0009822)2.20317687
63Absent forearm bone (HP:0003953)2.20317687
64Abnormality of the pons (HP:0007361)2.19670618
65Acute myeloid leukemia (HP:0004808)2.18874351
66Cerebellar dysplasia (HP:0007033)2.18569313
67High pitched voice (HP:0001620)2.12821791
68Abnormality of the carotid arteries (HP:0005344)2.12654864
69Abnormality of the nasal septum (HP:0000419)2.12282954
70Rough bone trabeculation (HP:0100670)2.11206487
71Short thumb (HP:0009778)2.10558613
72Supernumerary bones of the axial skeleton (HP:0009144)2.10340908
73Short 4th metacarpal (HP:0010044)2.08838194
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08838194
75Ureteral duplication (HP:0000073)2.07646405
76Chronic hepatic failure (HP:0100626)2.07035159
77Cystic liver disease (HP:0006706)2.06999354
78Genetic anticipation (HP:0003743)2.06656153
79Sclerocornea (HP:0000647)2.06462563
80Type II lissencephaly (HP:0007260)2.02804004
81Small hand (HP:0200055)2.02492304
82Oligodactyly (hands) (HP:0001180)2.02062877
83Supernumerary ribs (HP:0005815)2.01065739
84Clubbing of toes (HP:0100760)1.99049521
85Prominent nose (HP:0000448)1.98417883
86Preaxial hand polydactyly (HP:0001177)1.97444277
87Mesomelia (HP:0003027)1.94012068
88Attenuation of retinal blood vessels (HP:0007843)1.92833214
89Abnormality of the fingertips (HP:0001211)1.92820994
90Bone marrow hypocellularity (HP:0005528)1.91527916
91Increased CSF lactate (HP:0002490)1.90358095
92Pendular nystagmus (HP:0012043)1.90094967
93Colon cancer (HP:0003003)1.88846401
94Poor coordination (HP:0002370)1.88561917
95Congenital primary aphakia (HP:0007707)1.85471741
96Absent thumb (HP:0009777)1.85451609
97Abnormality of abdominal situs (HP:0011620)1.84996877
98Abdominal situs inversus (HP:0003363)1.84996877
99Deep philtrum (HP:0002002)1.84695853
100Nephrogenic diabetes insipidus (HP:0009806)1.84438991
101Astigmatism (HP:0000483)1.84030319
102Nephroblastoma (Wilms tumor) (HP:0002667)1.82382394
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.82282106
104Broad-based gait (HP:0002136)1.82226734
105Progressive inability to walk (HP:0002505)1.82189414
106Embryonal renal neoplasm (HP:0011794)1.82014967
107Dandy-Walker malformation (HP:0001305)1.81417757
108Gait imbalance (HP:0002141)1.80924398
109Tubular atrophy (HP:0000092)1.80867350
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.80255689
111Abnormality of the duodenum (HP:0002246)1.80142571
112Lissencephaly (HP:0001339)1.79963779
113Acute necrotizing encephalopathy (HP:0006965)1.79395238
114Highly arched eyebrow (HP:0002553)1.79248386
115Prostate neoplasm (HP:0100787)1.78224028
116Skull defect (HP:0001362)1.77704010
117Increased nuchal translucency (HP:0010880)1.76998541
118Tracheoesophageal fistula (HP:0002575)1.74810027
119Triphalangeal thumb (HP:0001199)1.74471772
120Long eyelashes (HP:0000527)1.74179549
121Anencephaly (HP:0002323)1.73636286
122Basal cell carcinoma (HP:0002671)1.73563204
123Gastrointestinal atresia (HP:0002589)1.73387251
124Partial agenesis of the corpus callosum (HP:0001338)1.72218489
125Sparse lateral eyebrow (HP:0005338)1.72035899
126Abnormality of chromosome segregation (HP:0002916)1.70853460
127Amaurosis fugax (HP:0100576)1.69889630
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.69521776
129Acute encephalopathy (HP:0006846)1.69253026
130Atresia of the external auditory canal (HP:0000413)1.68157487
131Microtia (HP:0008551)1.66406260
132Bile duct proliferation (HP:0001408)1.65763279
133Abnormal biliary tract physiology (HP:0012439)1.65763279
134Furrowed tongue (HP:0000221)1.65743275
135Congenital hepatic fibrosis (HP:0002612)1.65630947
136Natal tooth (HP:0000695)1.65432210
137Genital tract atresia (HP:0001827)1.65229876
138Bilateral microphthalmos (HP:0007633)1.65217844
139Large for gestational age (HP:0001520)1.64726142
140Abnormal lung lobation (HP:0002101)1.63429693
141Neoplasm of the pancreas (HP:0002894)1.62901349
142Truncal obesity (HP:0001956)1.62876904
143Hypoplastic iliac wings (HP:0002866)1.62348791
144Duplication of thumb phalanx (HP:0009942)1.61749912
145Cafe-au-lait spot (HP:0000957)1.61650749
146Aganglionic megacolon (HP:0002251)1.61246465
147Hypoplastic labia majora (HP:0000059)1.61213201
148Vaginal atresia (HP:0000148)1.60677912
149Increased serum lactate (HP:0002151)1.60001073
150Trigonocephaly (HP:0000243)1.59801580
151Homocystinuria (HP:0002156)1.59742665
152Abnormality of homocysteine metabolism (HP:0010919)1.59742665
153Intestinal fistula (HP:0100819)1.59595978
154Abnormal trabecular bone morphology (HP:0100671)1.58699519
155Inability to walk (HP:0002540)1.58574855
156Postaxial foot polydactyly (HP:0001830)1.58192040
157Abnormality of the incisor (HP:0000676)1.57795548
158Abnormal glycosylation (HP:0012345)1.57735446
159Lymphoma (HP:0002665)1.57598360
160Acute lymphatic leukemia (HP:0006721)1.55522116
16111 pairs of ribs (HP:0000878)1.53985730
162Long clavicles (HP:0000890)1.53689187
163Optic nerve coloboma (HP:0000588)1.53554047
164Squamous cell carcinoma (HP:0002860)1.52445190
165Ankle contracture (HP:0006466)1.52279710
166Urethral obstruction (HP:0000796)1.51826359
167Anal stenosis (HP:0002025)1.51767723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.87488233
2CDC74.28008526
3CDK123.78687648
4WEE13.17270939
5SRPK12.95536139
6BMPR1B2.95030988
7TSSK62.77007986
8MKNK22.63240949
9MKNK12.57705129
10LATS12.56939469
11BUB12.48435607
12TTK2.44400511
13NEK22.37390222
14PLK42.15340826
15ATR2.09767056
16BRD41.98341619
17WNK31.93679546
18PLK31.92459771
19ZAK1.83354985
20PLK11.75812875
21NUAK11.72320548
22CDK71.69220115
23GRK11.64714966
24ADRBK21.64601555
25WNK41.60148721
26PBK1.59802340
27CHEK11.59617507
28AURKB1.53853043
29EIF2AK11.52223126
30CASK1.51135606
31CDK41.50511032
32EIF2AK31.48397822
33MAP3K41.47339340
34TRIM281.44147812
35BRSK21.42418441
36PASK1.42279800
37EEF2K1.37635585
38RPS6KB21.35501192
39CHEK21.35264156
40EPHA21.34479423
41RPS6KA41.33709086
42PNCK1.32652954
43STK31.32568264
44INSRR1.32265926
45TNIK1.29148523
46CAMK1G1.24751052
47ATM1.22425143
48STK101.21031451
49MAPK131.18632113
50MAP4K21.15686237
51ALK1.12233088
52EIF2AK21.11301658
53AKT31.10850720
54IRAK31.09475116
55PDK21.07221561
56STK38L1.06789222
57STK391.06520868
58MAP3K81.06104068
59TAOK21.04881365
60TAF11.03659704
61PIM11.03337962
62VRK21.03127570
63NME11.01313762
64CDK21.00570502
65MARK30.94953734
66CDK60.94251498
67TXK0.93778658
68TLK10.91151094
69CDK10.87600838
70ERBB30.87048466
71CSNK1G10.82602469
72MTOR0.80447727
73NEK10.80299801
74YES10.79641935
75VRK10.79455509
76AURKA0.77444157
77BCR0.77246728
78PAK20.76716167
79JAK30.76536537
80OXSR10.76195945
81MAP3K140.75507711
82MST40.73134070
83NTRK30.70841382
84CSNK2A20.70741536
85IRAK40.68882821
86PLK20.67863972
87PRPF4B0.67812955
88TEC0.67481035
89CDK80.65779843
90NEK60.65597160
91CSNK1E0.64245284
92TGFBR10.64048333
93PRKDC0.63988281
94CHUK0.63502919
95RPS6KB10.62910480
96MAPKAPK50.62359646
97STK40.62058456
98FLT30.60148161
99MAP4K10.59470447
100PAK30.59320026
101CLK10.58863644
102PINK10.58828916
103NLK0.58496234
104DYRK20.56576289
105PRKCI0.56313586
106PRKCG0.56259722
107TRPM70.55960973
108FGFR20.55023185
109DYRK30.53958227
110FGFR10.52658173
111NEK90.52532799
112CSNK1D0.52264439
113TTN0.51006647
114TAOK30.50687129
115CSNK2A10.50523352
116NME20.49810175
117CCNB10.49539367
118MAPK140.48821951
119ADRBK10.48148157
120CSNK1A1L0.47827952
121AKT20.47132070
122PRKAA10.47012956
123CAMK1D0.46832198
124ACVR1B0.46683234
125MARK10.46628065
126MAP2K30.44633483
127GSK3B0.43557503
128BRSK10.42318397
129MELK0.42043962
130AKT10.42001845
131PRKACB0.41712685
132CDK30.40283362
133WNK10.40221226
134RPS6KA50.39433394
135MAPK10.39377569
136ERBB40.39358483
137CSF1R0.39337004
138MAP3K50.38788210
139PKN10.38150410
140PRKCE0.37909314
141IKBKB0.37705200
142PDGFRB0.35941873
143MAP2K70.35934518
144LATS20.33289003
145CDK90.30746582

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01390885
2DNA replication_Homo sapiens_hsa030303.92861881
3Mismatch repair_Homo sapiens_hsa034303.59260750
4RNA transport_Homo sapiens_hsa030133.22325832
5Spliceosome_Homo sapiens_hsa030403.16593729
6RNA polymerase_Homo sapiens_hsa030202.96360727
7Homologous recombination_Homo sapiens_hsa034402.95849115
8One carbon pool by folate_Homo sapiens_hsa006702.87628826
9Fanconi anemia pathway_Homo sapiens_hsa034602.73331625
10Base excision repair_Homo sapiens_hsa034102.62530076
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61152591
12Non-homologous end-joining_Homo sapiens_hsa034502.61094330
13Cell cycle_Homo sapiens_hsa041102.55931647
14Nucleotide excision repair_Homo sapiens_hsa034202.45175600
15mRNA surveillance pathway_Homo sapiens_hsa030152.12765864
16RNA degradation_Homo sapiens_hsa030182.08846314
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06338761
18Protein export_Homo sapiens_hsa030602.04304916
19Basal transcription factors_Homo sapiens_hsa030221.97440558
20Pyrimidine metabolism_Homo sapiens_hsa002401.93098077
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79340521
22Propanoate metabolism_Homo sapiens_hsa006401.72589796
23Vitamin B6 metabolism_Homo sapiens_hsa007501.69704251
24Phototransduction_Homo sapiens_hsa047441.66175140
25Butanoate metabolism_Homo sapiens_hsa006501.64372835
26p53 signaling pathway_Homo sapiens_hsa041151.59972853
27Nitrogen metabolism_Homo sapiens_hsa009101.40154192
28Ribosome_Homo sapiens_hsa030101.37333897
29Proteasome_Homo sapiens_hsa030501.36181714
30Epstein-Barr virus infection_Homo sapiens_hsa051691.35042689
31Oxidative phosphorylation_Homo sapiens_hsa001901.32710557
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.32536024
33Herpes simplex infection_Homo sapiens_hsa051681.30944610
34Purine metabolism_Homo sapiens_hsa002301.30178955
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27914875
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24137378
37Nicotine addiction_Homo sapiens_hsa050331.22473578
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21361060
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19912681
40Parkinsons disease_Homo sapiens_hsa050121.19457754
41Antigen processing and presentation_Homo sapiens_hsa046121.13224610
42Huntingtons disease_Homo sapiens_hsa050161.09107962
43Taste transduction_Homo sapiens_hsa047421.08364541
44Linoleic acid metabolism_Homo sapiens_hsa005911.06884969
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.06509984
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04957623
47MicroRNAs in cancer_Homo sapiens_hsa052061.04701705
48Viral carcinogenesis_Homo sapiens_hsa052031.02770687
49HTLV-I infection_Homo sapiens_hsa051661.02553176
50Small cell lung cancer_Homo sapiens_hsa052221.02044409
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97914614
52Ether lipid metabolism_Homo sapiens_hsa005650.97116769
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96570807
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95567252
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94669761
56Tryptophan metabolism_Homo sapiens_hsa003800.93181212
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84875744
58Primary immunodeficiency_Homo sapiens_hsa053400.84297648
59Basal cell carcinoma_Homo sapiens_hsa052170.83501842
60Steroid biosynthesis_Homo sapiens_hsa001000.83104881
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81532105
62Measles_Homo sapiens_hsa051620.81329729
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80294951
64Pyruvate metabolism_Homo sapiens_hsa006200.79405425
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78269267
66Olfactory transduction_Homo sapiens_hsa047400.77465456
67Systemic lupus erythematosus_Homo sapiens_hsa053220.75024956
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71766714
69TGF-beta signaling pathway_Homo sapiens_hsa043500.70774915
70ABC transporters_Homo sapiens_hsa020100.69882700
71Oocyte meiosis_Homo sapiens_hsa041140.66503509
72Adherens junction_Homo sapiens_hsa045200.64956106
73Prostate cancer_Homo sapiens_hsa052150.64244984
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62913666
75Hippo signaling pathway_Homo sapiens_hsa043900.62803030
76Metabolic pathways_Homo sapiens_hsa011000.59175316
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59019649
78Lysine degradation_Homo sapiens_hsa003100.57991066
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.57929061
80Alzheimers disease_Homo sapiens_hsa050100.57838086
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.56628268
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.55026687
83Autoimmune thyroid disease_Homo sapiens_hsa053200.54922408
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54859999
85Chronic myeloid leukemia_Homo sapiens_hsa052200.53456549
86Peroxisome_Homo sapiens_hsa041460.53248633
87Pathways in cancer_Homo sapiens_hsa052000.52715068
88Viral myocarditis_Homo sapiens_hsa054160.52225843
89Apoptosis_Homo sapiens_hsa042100.52087016
90beta-Alanine metabolism_Homo sapiens_hsa004100.51854800
91Hepatitis B_Homo sapiens_hsa051610.50267964
92Legionellosis_Homo sapiens_hsa051340.49669608
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49551918
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49246167
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48512783
96Hematopoietic cell lineage_Homo sapiens_hsa046400.47156087
97Influenza A_Homo sapiens_hsa051640.46513475
98T cell receptor signaling pathway_Homo sapiens_hsa046600.46144322
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46089133
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45673905
101TNF signaling pathway_Homo sapiens_hsa046680.45471079
102Morphine addiction_Homo sapiens_hsa050320.44833370
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44533897
104Fatty acid metabolism_Homo sapiens_hsa012120.43805036
105Notch signaling pathway_Homo sapiens_hsa043300.43554185
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.43315205
107Selenocompound metabolism_Homo sapiens_hsa004500.43168501
108Thyroid cancer_Homo sapiens_hsa052160.43137956
109Glycerolipid metabolism_Homo sapiens_hsa005610.42460315
110ECM-receptor interaction_Homo sapiens_hsa045120.42075131
111Caffeine metabolism_Homo sapiens_hsa002320.41990448
112Colorectal cancer_Homo sapiens_hsa052100.41527890
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40138091
114Wnt signaling pathway_Homo sapiens_hsa043100.39863260
115Cardiac muscle contraction_Homo sapiens_hsa042600.39240312
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38905113
117Allograft rejection_Homo sapiens_hsa053300.38562930
118Proteoglycans in cancer_Homo sapiens_hsa052050.37985933
119Acute myeloid leukemia_Homo sapiens_hsa052210.37776862
120Graft-versus-host disease_Homo sapiens_hsa053320.37442457
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36471475
122Retinol metabolism_Homo sapiens_hsa008300.36366490
123HIF-1 signaling pathway_Homo sapiens_hsa040660.36234662
124Toxoplasmosis_Homo sapiens_hsa051450.36003152
125Melanoma_Homo sapiens_hsa052180.35810347
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.35664471
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35565248
128N-Glycan biosynthesis_Homo sapiens_hsa005100.34124513
129Glutamatergic synapse_Homo sapiens_hsa047240.33855396
130Sulfur relay system_Homo sapiens_hsa041220.32437374
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32244820
132Fatty acid biosynthesis_Homo sapiens_hsa000610.31578881
133Vitamin digestion and absorption_Homo sapiens_hsa049770.31543401
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31227935
135Hedgehog signaling pathway_Homo sapiens_hsa043400.29869598
136Calcium signaling pathway_Homo sapiens_hsa040200.28537976
137Serotonergic synapse_Homo sapiens_hsa047260.28035168
138Circadian entrainment_Homo sapiens_hsa047130.27929393
139Focal adhesion_Homo sapiens_hsa045100.27821503
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27321519
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27207462
142Shigellosis_Homo sapiens_hsa051310.26893993
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26700380
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26634431
145GABAergic synapse_Homo sapiens_hsa047270.26551408
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26435037
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26360914
148Regulation of autophagy_Homo sapiens_hsa041400.26044357
149B cell receptor signaling pathway_Homo sapiens_hsa046620.25898172
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25848696
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25677123
152mTOR signaling pathway_Homo sapiens_hsa041500.25621664
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25463647
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25382360
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.25324522
156Leishmaniasis_Homo sapiens_hsa051400.24784567
157Malaria_Homo sapiens_hsa051440.24440440
158FoxO signaling pathway_Homo sapiens_hsa040680.23971908
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.23831574
160Circadian rhythm_Homo sapiens_hsa047100.23692946
161Inositol phosphate metabolism_Homo sapiens_hsa005620.22592596
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21586973
163Type I diabetes mellitus_Homo sapiens_hsa049400.21534870

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »