RBM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.07930173
2viral transcription (GO:0019083)4.67474212
3DNA unwinding involved in DNA replication (GO:0006268)4.66627231
4translational termination (GO:0006415)4.58898808
5DNA strand elongation involved in DNA replication (GO:0006271)4.26129355
6protein localization to kinetochore (GO:0034501)4.13956826
7translational elongation (GO:0006414)4.06823204
8telomere maintenance via semi-conservative replication (GO:0032201)4.06593584
9DNA strand elongation (GO:0022616)4.03831504
10maturation of SSU-rRNA (GO:0030490)4.01527462
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96824393
12ribosomal small subunit biogenesis (GO:0042274)3.88987545
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.87927156
14protein targeting to ER (GO:0045047)3.85450892
15cotranslational protein targeting to membrane (GO:0006613)3.85188243
16DNA replication initiation (GO:0006270)3.79499900
17translational initiation (GO:0006413)3.78449633
18formation of translation preinitiation complex (GO:0001731)3.75833217
19telomere maintenance via recombination (GO:0000722)3.73304126
20mitotic recombination (GO:0006312)3.70964396
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68132949
22viral life cycle (GO:0019058)3.61052713
23cellular protein complex disassembly (GO:0043624)3.59194709
24protein localization to endoplasmic reticulum (GO:0070972)3.57056627
25protein localization to chromosome, centromeric region (GO:0071459)3.52472772
26mitotic chromosome condensation (GO:0007076)3.49639718
27mitotic nuclear envelope disassembly (GO:0007077)3.41741688
28negative regulation of RNA splicing (GO:0033119)3.39281587
29ribosomal large subunit biogenesis (GO:0042273)3.31585797
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30836492
31nuclear pore organization (GO:0006999)3.29527005
32protein complex disassembly (GO:0043241)3.28366038
33kinetochore organization (GO:0051383)3.27151847
34CENP-A containing nucleosome assembly (GO:0034080)3.25548333
35nuclear pore complex assembly (GO:0051292)3.23153663
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.23063096
37DNA replication-dependent nucleosome organization (GO:0034723)3.20346089
38DNA replication-dependent nucleosome assembly (GO:0006335)3.20346089
39membrane disassembly (GO:0030397)3.19568599
40nuclear envelope disassembly (GO:0051081)3.19568599
41telomere maintenance via telomere lengthening (GO:0010833)3.16894337
42chromatin remodeling at centromere (GO:0031055)3.15885694
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15087424
44DNA replication-independent nucleosome organization (GO:0034724)3.14588522
45DNA replication-independent nucleosome assembly (GO:0006336)3.14588522
46mitotic sister chromatid cohesion (GO:0007064)3.13662948
47ribosome biogenesis (GO:0042254)3.13549844
48nuclear-transcribed mRNA catabolic process (GO:0000956)3.12010080
49DNA topological change (GO:0006265)3.09811261
50macromolecular complex disassembly (GO:0032984)3.07423065
51DNA replication checkpoint (GO:0000076)3.07232392
52sister chromatid segregation (GO:0000819)3.06453231
53COPI coating of Golgi vesicle (GO:0048205)2.99868899
54Golgi transport vesicle coating (GO:0048200)2.99868899
55translesion synthesis (GO:0019985)2.97564619
56DNA duplex unwinding (GO:0032508)2.97383450
57mRNA catabolic process (GO:0006402)2.97015394
58attachment of spindle microtubules to kinetochore (GO:0008608)2.95585101
59DNA geometric change (GO:0032392)2.95584036
60folic acid-containing compound biosynthetic process (GO:0009396)2.94810171
61regulation of protein heterodimerization activity (GO:0043497)2.94011092
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90801265
63proteasome assembly (GO:0043248)2.90792513
64ribonucleoprotein complex biogenesis (GO:0022613)2.90192977
65RNA catabolic process (GO:0006401)2.88532562
66mitotic sister chromatid segregation (GO:0000070)2.87229621
67nucleobase-containing small molecule interconversion (GO:0015949)2.87048703
68mitotic metaphase plate congression (GO:0007080)2.86831370
69IMP biosynthetic process (GO:0006188)2.81918957
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77878710
71regulation of translational termination (GO:0006449)2.77062057
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76491728
73dosage compensation (GO:0007549)2.74777994
74pinocytosis (GO:0006907)2.73080995
75chromatin assembly or disassembly (GO:0006333)2.72226279
76nucleobase biosynthetic process (GO:0046112)2.68150456
77negative regulation of mRNA processing (GO:0050686)2.67996182
78establishment of integrated proviral latency (GO:0075713)2.66590515
79regulation of spindle organization (GO:0090224)2.66520848
80cellular component biogenesis (GO:0044085)2.66112660
81postreplication repair (GO:0006301)2.65649926
82negative regulation of ligase activity (GO:0051352)2.64397790
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64397790
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64311309
85mRNA splicing, via spliceosome (GO:0000398)2.64311309
86IMP metabolic process (GO:0046040)2.64253357
87alternative mRNA splicing, via spliceosome (GO:0000380)2.63578586
88telomere maintenance (GO:0000723)2.63306551
89metaphase plate congression (GO:0051310)2.63083505
90RNA splicing, via transesterification reactions (GO:0000375)2.63052934
91telomere organization (GO:0032200)2.61342915
92establishment of chromosome localization (GO:0051303)2.60195728
93rRNA processing (GO:0006364)2.59724506
94termination of RNA polymerase II transcription (GO:0006369)2.57319511
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56632301
96meiotic chromosome segregation (GO:0045132)2.55447993
97* translation (GO:0006412)2.55258600
98establishment of viral latency (GO:0019043)2.55213734
99protein targeting to membrane (GO:0006612)2.54257563
100DNA deamination (GO:0045006)2.54055403
101DNA conformation change (GO:0071103)2.53389726
102pore complex assembly (GO:0046931)2.53179754
103histone exchange (GO:0043486)2.52892233
104nuclear envelope organization (GO:0006998)2.52570248
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52357482
106ATP-dependent chromatin remodeling (GO:0043044)2.51172005
107positive regulation of chromosome segregation (GO:0051984)2.50171528
108regulation of sister chromatid cohesion (GO:0007063)2.50162401
109rRNA metabolic process (GO:0016072)2.49982069
110ribosome assembly (GO:0042255)2.49549749
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.49426759
112protein localization to chromosome (GO:0034502)2.49285969
113kinetochore assembly (GO:0051382)2.48481553
114Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47768450
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46736889
116G1/S transition of mitotic cell cycle (GO:0000082)2.45399067
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43100392
118antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42438471
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42305254
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42305254
121protein maturation by protein folding (GO:0022417)2.41786379
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.41698507
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41698507
124viral mRNA export from host cell nucleus (GO:0046784)2.39200673
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.38502671
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.38502671
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.38502671
128membrane raft organization (GO:0031579)2.36236655
129NIK/NF-kappaB signaling (GO:0038061)2.35243066
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.33421777
131myeloid cell homeostasis (GO:0002262)2.31719103
132protein targeting to mitochondrion (GO:0006626)2.31136831
133spliceosomal snRNP assembly (GO:0000387)2.28802946
134pseudouridine synthesis (GO:0001522)2.26656661
135regulation of translational fidelity (GO:0006450)2.24001949
136nuclear envelope reassembly (GO:0031468)2.20752925
137mitotic nuclear envelope reassembly (GO:0007084)2.20752925
138ribonucleoprotein complex assembly (GO:0022618)2.20639815
139regulation of cellular amino acid metabolic process (GO:0006521)2.20560784
140T cell apoptotic process (GO:0070231)2.20259735
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.18675034
142transcription from mitochondrial promoter (GO:0006390)2.16629481
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.15627410
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.15024919
145pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.14194088
146establishment of protein localization to membrane (GO:0090150)2.13966448
147tRNA methylation (GO:0030488)2.12126326
148necroptotic process (GO:0070266)2.12007000
149guanosine-containing compound biosynthetic process (GO:1901070)2.11635714
150pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.11633541
151gene expression (GO:0010467)2.10433486
152ribonucleoprotein complex subunit organization (GO:0071826)2.10061422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.27973533
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42691825
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83781457
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.81222503
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59049287
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14993745
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.01692281
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64345263
9MYC_22102868_ChIP-Seq_BL_Human2.41924364
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40941265
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.33390496
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.28803011
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21571350
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19454584
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17752184
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.15156855
17XRN2_22483619_ChIP-Seq_HELA_Human2.14228826
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11033586
19AR_21909140_ChIP-Seq_LNCAP_Human2.09568753
20VDR_23849224_ChIP-Seq_CD4+_Human2.06511649
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05876512
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.03597543
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03101695
24* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96086629
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.93099287
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90956373
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88973575
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79869270
29FOXP3_21729870_ChIP-Seq_TREG_Human1.78837783
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77463912
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76756086
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75047765
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72062806
34DCP1A_22483619_ChIP-Seq_HELA_Human1.70276144
35TTF2_22483619_ChIP-Seq_HELA_Human1.70128633
36CIITA_25753668_ChIP-Seq_RAJI_Human1.69071233
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68992589
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67780134
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64337231
40VDR_21846776_ChIP-Seq_THP-1_Human1.63031785
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62733029
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61821380
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58620474
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57056017
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53033057
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50684604
47GABP_19822575_ChIP-Seq_HepG2_Human1.50615509
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47574981
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46739540
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45838397
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.45466485
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42091314
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41879670
54* SPI1_23547873_ChIP-Seq_NB4_Human1.40351129
55* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40111863
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37760173
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34087098
58MYB_26560356_Chip-Seq_TH2_Human1.33815324
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30513237
60ZNF263_19887448_ChIP-Seq_K562_Human1.30035532
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29787824
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.29634664
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28739036
64KDM5A_27292631_Chip-Seq_BREAST_Human1.28675234
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27035377
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.26813811
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26687088
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24285193
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23118988
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22213788
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.21122367
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20579301
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20030721
74TFEB_21752829_ChIP-Seq_HELA_Human1.19808107
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19611795
76MAF_26560356_Chip-Seq_TH1_Human1.18991713
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18799020
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18671338
79* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15665009
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.15318809
81UTX_26944678_Chip-Seq_JUKART_Human1.14168881
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13810065
83MYB_26560356_Chip-Seq_TH1_Human1.13306260
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12696173
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12296052
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11603844
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11453665
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10851633
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10678558
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.10333279
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.07555972
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07238305
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04481242
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04032704
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04027936
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03979085
97* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02382330
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02316817
99SCL_19346495_ChIP-Seq_HPC-7_Human1.00770806
100* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00020790
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99556482
102VDR_24763502_ChIP-Seq_THP-1_Human0.99440034
103RUNX1_22412390_ChIP-Seq_EML_Mouse0.98722071
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97837893
105* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96825002
106BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96633141
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96065507
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93994658
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.90809047
110IRF8_21731497_ChIP-ChIP_J774_Mouse0.90516926
111TCF7_22412390_ChIP-Seq_EML_Mouse0.89811304
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88788280
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86887081
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86586863
115* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86533805
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83644101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.56204558
2MP0010094_abnormal_chromosome_stability3.37360941
3MP0004957_abnormal_blastocyst_morpholog3.09804527
4MP0003111_abnormal_nucleus_morphology2.85215355
5MP0003077_abnormal_cell_cycle2.84728952
6MP0008057_abnormal_DNA_replication2.71194617
7MP0002396_abnormal_hematopoietic_system2.69058383
8MP0010352_gastrointestinal_tract_polyps2.68383405
9MP0008007_abnormal_cellular_replicative2.36819218
10MP0006054_spinal_hemorrhage2.22813435
11MP0004808_abnormal_hematopoietic_stem2.17201474
12MP0003763_abnormal_thymus_physiology2.07324976
13MP0008058_abnormal_DNA_repair1.94965967
14MP0010307_abnormal_tumor_latency1.85456665
15MP0000490_abnormal_crypts_of1.84283014
16MP0003806_abnormal_nucleotide_metabolis1.80683141
17MP0001835_abnormal_antigen_presentation1.77373899
18MP0008932_abnormal_embryonic_tissue1.76403144
19MP0000350_abnormal_cell_proliferation1.76000902
20MP0002796_impaired_skin_barrier1.72327307
21MP0002166_altered_tumor_susceptibility1.70275628
22MP0009333_abnormal_splenocyte_physiolog1.68565503
23MP0002398_abnormal_bone_marrow1.66713379
24MP0001730_embryonic_growth_arrest1.60964504
25MP0003950_abnormal_plasma_membrane1.57238208
26MP0000703_abnormal_thymus_morphology1.56183470
27MP0003705_abnormal_hypodermis_morpholog1.52044526
28MP0000685_abnormal_immune_system1.50600223
29MP0005501_abnormal_skin_physiology1.49369119
30MP0002006_tumorigenesis1.47537695
31MP0005397_hematopoietic_system_phenotyp1.45260710
32MP0001545_abnormal_hematopoietic_system1.45260710
33MP0005076_abnormal_cell_differentiation1.44843585
34MP0003123_paternal_imprinting1.43080599
35MP0001800_abnormal_humoral_immune1.42474660
36MP0002722_abnormal_immune_system1.41899734
37MP0002877_abnormal_melanocyte_morpholog1.41486530
38MP0003191_abnormal_cellular_cholesterol1.40446485
39MP0002019_abnormal_tumor_incidence1.39746821
40MP0005671_abnormal_response_to1.36045300
41MP0000689_abnormal_spleen_morphology1.34413860
42MP0002452_abnormal_antigen_presenting1.31356520
43MP0002420_abnormal_adaptive_immunity1.29458903
44MP0008260_abnormal_autophagy1.28879965
45MP0001819_abnormal_immune_cell1.27424921
46MP0003786_premature_aging1.26091477
47MP0000716_abnormal_immune_system1.25494748
48MP0008438_abnormal_cutaneous_collagen1.25188979
49MP0003300_gastrointestinal_ulcer1.24570528
50MP0001697_abnormal_embryo_size1.24481763
51MP0009278_abnormal_bone_marrow1.23860779
52MP0002429_abnormal_blood_cell1.22540741
53MP0002405_respiratory_system_inflammati1.21100367
54MP0000858_altered_metastatic_potential1.20898536
55MP0004197_abnormal_fetal_growth/weight/1.19094477
56MP0004185_abnormal_adipocyte_glucose1.17869530
57MP0003567_abnormal_fetal_cardiomyocyte1.16806499
58MP0002080_prenatal_lethality1.16278717
59MP0005380_embryogenesis_phenotype1.16251855
60MP0001672_abnormal_embryogenesis/_devel1.16251855
61MP0000313_abnormal_cell_death1.16048582
62MP0000465_gastrointestinal_hemorrhage1.15618507
63MP0005058_abnormal_lysosome_morphology1.14550817
64MP0004782_abnormal_surfactant_physiolog1.14529706
65MP0001542_abnormal_bone_strength1.13853257
66MP0003186_abnormal_redox_activity1.12931892
67MP0003984_embryonic_growth_retardation1.11979607
68MP0005023_abnormal_wound_healing1.11462426
69MP0003566_abnormal_cell_adhesion1.11434507
70MP0005000_abnormal_immune_tolerance1.11034898
71MP0003436_decreased_susceptibility_to1.10291542
72MP0002723_abnormal_immune_serum1.10197821
73MP0002088_abnormal_embryonic_growth/wei1.09829094
74MP0001853_heart_inflammation1.09334868
75MP0003828_pulmonary_edema1.08867629
76MP0001881_abnormal_mammary_gland1.08157908
77MP0002086_abnormal_extraembryonic_tissu1.08035454
78MP0005408_hypopigmentation1.07569756
79MP0001873_stomach_inflammation1.07122449
80MP0005464_abnormal_platelet_physiology1.03864734
81MP0003453_abnormal_keratinocyte_physiol1.01046035
82* MP0002085_abnormal_embryonic_tissue1.00591385
83MP0010155_abnormal_intestine_physiology0.99963992
84MP0009785_altered_susceptibility_to0.99074756
85MP0004947_skin_inflammation0.98288400
86MP0002095_abnormal_skin_pigmentation0.97876006
87MP0005275_abnormal_skin_tensile0.97583269
88* MP0002084_abnormal_developmental_patter0.96958309
89MP0005451_abnormal_body_composition0.95188463
90MP0010030_abnormal_orbit_morphology0.94646112
91MP0000537_abnormal_urethra_morphology0.94387344
92MP0003448_altered_tumor_morphology0.94046372
93MP0000733_abnormal_muscle_development0.92326450
94MP0005025_abnormal_response_to0.91415752
95MP0005387_immune_system_phenotype0.91283526
96MP0001790_abnormal_immune_system0.91283526
97MP0003221_abnormal_cardiomyocyte_apopto0.90048950
98MP0005075_abnormal_melanosome_morpholog0.89715466
99MP0003121_genomic_imprinting0.89554999
100MP0010234_abnormal_vibrissa_follicle0.89274441
101MP0001845_abnormal_inflammatory_respons0.89002932
102MP0005257_abnormal_intraocular_pressure0.88913906
103MP0003091_abnormal_cell_migration0.88762221
104MP0000383_abnormal_hair_follicle0.88572317
105MP0001293_anophthalmia0.86614901
106MP0002933_joint_inflammation0.86103804
107MP0003279_aneurysm0.85431191
108MP0000343_altered_response_to0.85101996
109MP0000627_abnormal_mammary_gland0.84394733
110MP0002009_preneoplasia0.82653037
111MP0001243_abnormal_dermal_layer0.82479579
112MP0009053_abnormal_anal_canal0.82254746
113MP0001727_abnormal_embryo_implantation0.82235783
114MP0001533_abnormal_skeleton_physiology0.82217462
115MP0010368_abnormal_lymphatic_system0.81504156
116MP0000358_abnormal_cell_content/0.78962291
117MP0005174_abnormal_tail_pigmentation0.78222474
118MP0008877_abnormal_DNA_methylation0.76328827
119MP0001915_intracranial_hemorrhage0.74753811
120MP0000377_abnormal_hair_follicle0.74283925
121MP0002148_abnormal_hypersensitivity_rea0.73566404
122MP0005503_abnormal_tendon_morphology0.73217709
123MP0003303_peritoneal_inflammation0.72880998
124MP0002060_abnormal_skin_morphology0.72143754
125MP0009379_abnormal_foot_pigmentation0.70657406
126MP0000477_abnormal_intestine_morphology0.69646855
127MP0002419_abnormal_innate_immunity0.68598085
128MP0005621_abnormal_cell_physiology0.68282110
129MP0001216_abnormal_epidermal_layer0.67421863

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.08437301
2Abnormality of cells of the erythroid lineage (HP:0012130)3.99587075
3Abnormal number of erythroid precursors (HP:0012131)3.65869717
4Selective tooth agenesis (HP:0001592)2.92379357
5Thrombocytosis (HP:0001894)2.91935564
6Microvesicular hepatic steatosis (HP:0001414)2.91607158
7IgM deficiency (HP:0002850)2.83001419
8Colon cancer (HP:0003003)2.78354494
9Reduced subcutaneous adipose tissue (HP:0003758)2.76332398
10Premature rupture of membranes (HP:0001788)2.71018285
11Pallor (HP:0000980)2.67986741
12Vertebral compression fractures (HP:0002953)2.66566278
13Birth length less than 3rd percentile (HP:0003561)2.66474813
14Short 4th metacarpal (HP:0010044)2.56932639
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56932639
16Autoimmune hemolytic anemia (HP:0001890)2.50891171
17Fatigue (HP:0012378)2.48768302
18Spondylolisthesis (HP:0003302)2.47971265
1911 pairs of ribs (HP:0000878)2.47625958
20Increased density of long bones (HP:0006392)2.44369913
21Increased IgM level (HP:0003496)2.40593559
22Cutaneous melanoma (HP:0012056)2.32166248
23Deviation of the thumb (HP:0009603)2.31226687
24B lymphocytopenia (HP:0010976)2.25710046
25Abnormality of B cell number (HP:0010975)2.25710046
26Proximal placement of thumb (HP:0009623)2.24259011
27Aplastic anemia (HP:0001915)2.23926775
28Myelodysplasia (HP:0002863)2.23081331
29Macrocytic anemia (HP:0001972)2.22374239
30Progressive muscle weakness (HP:0003323)2.22235862
31Hypertensive crisis (HP:0100735)2.21829710
32Onycholysis (HP:0001806)2.20642196
33Basal cell carcinoma (HP:0002671)2.19908131
34Abnormality of the umbilical cord (HP:0010881)2.19131828
35Abnormality of the calcaneus (HP:0008364)2.18997295
36Volvulus (HP:0002580)2.18306589
37Abnormality of chromosome stability (HP:0003220)2.18298578
38Recurrent viral infections (HP:0004429)2.17415803
39Abnormality of the anterior horn cell (HP:0006802)2.14666664
40Degeneration of anterior horn cells (HP:0002398)2.14666664
41Chromsome breakage (HP:0040012)2.13686853
42Abnormal trabecular bone morphology (HP:0100671)2.13241927
43Glossoptosis (HP:0000162)2.12500691
44Recurrent bronchitis (HP:0002837)2.11687759
45Lymphoma (HP:0002665)2.09790060
46Respiratory difficulties (HP:0002880)2.08943852
47Hepatosplenomegaly (HP:0001433)2.07959848
48Short nail (HP:0001799)2.07348826
49T lymphocytopenia (HP:0005403)2.05901746
50Oral leukoplakia (HP:0002745)2.05372439
51Abnormal umbilical cord blood vessels (HP:0011403)2.02913106
52Single umbilical artery (HP:0001195)2.02913106
53Abnormality of the fetal cardiovascular system (HP:0010948)2.02913106
54Granulocytopenia (HP:0001913)2.02874298
55Abnormality of T cells (HP:0002843)2.01921415
56Pancytopenia (HP:0001876)1.98921499
57Elevated erythrocyte sedimentation rate (HP:0003565)1.98155463
58Increased nuchal translucency (HP:0010880)1.98032589
59Abnormal number of incisors (HP:0011064)1.97202185
60Abnormality of the distal phalanges of the toes (HP:0010182)1.96884524
61Protrusio acetabuli (HP:0003179)1.95889745
62Panhypogammaglobulinemia (HP:0003139)1.95384904
63Increased hepatocellular lipid droplets (HP:0006565)1.94634021
64Atresia of the external auditory canal (HP:0000413)1.94493276
65Squamous cell carcinoma (HP:0002860)1.94471018
66Abnormal delayed hypersensitivity skin test (HP:0002963)1.93960437
67Abnormality of T cell number (HP:0011839)1.93515987
68IgG deficiency (HP:0004315)1.93313083
69Medulloblastoma (HP:0002885)1.92880456
70Patellar aplasia (HP:0006443)1.90768251
71Ankle contracture (HP:0006466)1.90688207
72Acute myeloid leukemia (HP:0004808)1.89938666
73Entropion (HP:0000621)1.89615559
74Neoplasm of the pancreas (HP:0002894)1.88046150
75Agnosia (HP:0010524)1.87961715
76Abnormality of the preputium (HP:0100587)1.87811515
77Bicuspid aortic valve (HP:0001647)1.87489639
78Trismus (HP:0000211)1.87107234
79Sparse eyelashes (HP:0000653)1.84958776
80Chronic otitis media (HP:0000389)1.84357433
81Premature graying of hair (HP:0002216)1.82054970
82Microretrognathia (HP:0000308)1.81998734
83Meckel diverticulum (HP:0002245)1.81422325
84Abnormality of T cell physiology (HP:0011840)1.80634707
85High pitched voice (HP:0001620)1.80250381
86Aplasia/Hypoplasia of the patella (HP:0006498)1.79819036
87Osteolytic defects of the hand bones (HP:0009699)1.79814916
88Osteolytic defects of the phalanges of the hand (HP:0009771)1.79814916
89Delayed cranial suture closure (HP:0000270)1.79332053
90Cellulitis (HP:0100658)1.79292675
91Abnormalities of placenta or umbilical cord (HP:0001194)1.77981165
92Exertional dyspnea (HP:0002875)1.77941308
93Absent thumb (HP:0009777)1.77812985
94Abnormality of cells of the lymphoid lineage (HP:0012140)1.77600374
95Autoimmune thrombocytopenia (HP:0001973)1.77582600
96Sparse lateral eyebrow (HP:0005338)1.77428308
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76090810
98Poikiloderma (HP:0001029)1.75466360
99Cervical subluxation (HP:0003308)1.75465483
100Prominent nose (HP:0000448)1.74200968
101Conjunctival hamartoma (HP:0100780)1.74153612
102IgA deficiency (HP:0002720)1.73902536
103Abnormality of the ileum (HP:0001549)1.73110424
104Lymphopenia (HP:0001888)1.72353230
105Renal Fanconi syndrome (HP:0001994)1.71610619
106Ureteral duplication (HP:0000073)1.70783245
107Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70427859
108Redundant skin (HP:0001582)1.70350022
109Duodenal stenosis (HP:0100867)1.70186916
110Small intestinal stenosis (HP:0012848)1.70186916
111Rough bone trabeculation (HP:0100670)1.69956700
112Spinal cord lesions (HP:0100561)1.68906543
113Syringomyelia (HP:0003396)1.68906543
114Breast hypoplasia (HP:0003187)1.68825011
115Agammaglobulinemia (HP:0004432)1.68157078
116Deep philtrum (HP:0002002)1.67488274
117Increased serum pyruvate (HP:0003542)1.67106633
118Mediastinal lymphadenopathy (HP:0100721)1.66807531
119Abnormality of the fingertips (HP:0001211)1.66790051
120Small epiphyses (HP:0010585)1.66699320
121Ragged-red muscle fibers (HP:0003200)1.66272504
122Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.66136524
123Decreased activity of mitochondrial respiratory chain (HP:0008972)1.66136524
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.65720736
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.64934868
126Combined immunodeficiency (HP:0005387)1.64899423
127Amaurosis fugax (HP:0100576)1.64474921
128Nail dystrophy (HP:0008404)1.64219966
129Petechiae (HP:0000967)1.64034274
130Severe combined immunodeficiency (HP:0004430)1.63980111
131Glucose intolerance (HP:0000833)1.63877036
132Hypergammaglobulinemia (HP:0010702)1.63819258
133Slender long bone (HP:0003100)1.63792493
134Myositis (HP:0100614)1.62314738
135Missing ribs (HP:0000921)1.62068879
136Abnormality of the 4th metacarpal (HP:0010012)1.61787706
137Thyroiditis (HP:0100646)1.60264596
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.60187952
139Short clavicles (HP:0000894)1.60130659
140Optic nerve coloboma (HP:0000588)1.59217413
141Flared metaphyses (HP:0003015)1.58973084
142Spastic diplegia (HP:0001264)1.58228330
143Rectal prolapse (HP:0002035)1.58163174
144Gastrointestinal stroma tumor (HP:0100723)1.58053241
145Erythema (HP:0010783)1.57969327
146Microglossia (HP:0000171)1.57913666
147Lipid accumulation in hepatocytes (HP:0006561)1.57206625
148Increased serum lactate (HP:0002151)1.56790524
149Dilatation of the ascending aorta (HP:0005111)1.55931803
150Short middle phalanx of the 5th finger (HP:0004220)1.55316611
151Secondary amenorrhea (HP:0000869)1.54633144
152Bone marrow hypocellularity (HP:0005528)1.54321384
153Mesomelia (HP:0003027)1.54013075
154Increased intramyocellular lipid droplets (HP:0012240)1.53786831
155Blepharitis (HP:0000498)1.53418955
156Pustule (HP:0200039)1.52751450
157Skin ulcer (HP:0200042)1.52072641
158Viral hepatitis (HP:0006562)1.51827675
159Multiple enchondromatosis (HP:0005701)1.51438687
160Fragile nails (HP:0001808)1.51224961
161Eczematoid dermatitis (HP:0000976)1.50769447
162Death in infancy (HP:0001522)1.50757920
163Reduced antithrombin III activity (HP:0001976)1.50036392
164Amniotic constriction ring (HP:0009775)1.49443523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.63137182
2WEE12.83619160
3EEF2K2.82552693
4BUB12.70790724
5IRAK32.68295269
6NME22.41816107
7NEK22.41388247
8PBK2.25020020
9EIF2AK12.24946704
10VRK22.18715473
11MAP4K12.11955564
12RPS6KA42.06267668
13RPS6KB22.04445982
14PASK2.03685713
15PRPF4B2.02089864
16PKN21.95380051
17STK101.95342193
18MAP3K141.89005855
19SRPK11.87494924
20LRRK21.85557717
21SMG11.77249388
22ACVR1B1.76235432
23MAP3K101.74889805
24TGFBR11.73955436
25MKNK11.69593565
26BRSK21.66888468
27EIF2AK31.65774322
28TESK21.63431689
29SCYL21.63422579
30PDK21.60438400
31ATR1.49795831
32VRK11.48801854
33DYRK31.48313491
34* AURKB1.48068068
35CDK71.44493066
36TRIB31.38167564
37CDK41.35109771
38FLT31.32209068
39CDK61.26652224
40PAK41.26437345
41MAP3K81.24049264
42TESK11.23240199
43NEK11.22741039
44PLK11.21590734
45MST41.21532880
46TTK1.19358726
47TSSK61.16279559
48CDK121.15424155
49STK41.15206008
50PIM11.15097976
51TAOK21.14552253
52BTK1.12754104
53TLK11.12422472
54PLK41.07605629
55PIM21.04691805
56ERBB31.04320989
57ZAP701.03776041
58JAK31.03372716
59TTN1.02560191
60ERBB41.02379329
61PLK30.94371821
62MAPKAPK30.91806577
63CSF1R0.91252916
64CHEK10.88935878
65TEC0.88766270
66GRK60.88475053
67KIT0.87134994
68SIK30.86984220
69MAP3K120.85203131
70TXK0.85183831
71BRSK10.83180000
72CHEK20.82840748
73CCNB10.82693726
74BMPR20.81100974
75MAP2K30.79724059
76MKNK20.78725041
77ITK0.77748026
78TYK20.77529378
79TRPM70.76782628
80STK30.76769094
81KDR0.76720587
82ILK0.76382967
83ZAK0.72180640
84ABL20.70915916
85STK240.68824183
86CLK10.68771909
87CDK80.67666918
88MOS0.66164200
89IKBKE0.65483187
90MELK0.65410662
91ATM0.65003928
92CDK90.63467547
93AURKA0.62031794
94ALK0.60810547
95PAK20.59881487
96SYK0.59600570
97NEK90.58969489
98IRAK40.57766969
99BLK0.56073226
100CDK20.55942594
101LIMK10.55677935
102TAF10.54531888
103MST1R0.54194939
104MAP3K30.53664218
105EIF2AK20.52833824
106RPS6KA50.52538656
107LCK0.52432485
108MAPK110.51096453
109IKBKB0.50965669
110PTK60.48665255
111TBK10.48320456
112FGFR30.47746217
113BRD40.47291023
114LYN0.46987019
115CSNK2A20.46861194
116CHUK0.46483199
117STK160.44690373
118FGFR10.44451867
119DYRK1B0.43630883
120MAPKAPK20.43109339
121PDGFRA0.43038312
122TGFBR20.42548673
123MYLK0.40565175
124CSK0.40118336
125EPHA20.39963949
126BCKDK0.38980297
127ERN10.38563973
128CSNK2A10.38284369
129PAK10.35565136

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32005459
2Ribosome_Homo sapiens_hsa030103.42877242
3Mismatch repair_Homo sapiens_hsa034303.41152404
4Spliceosome_Homo sapiens_hsa030402.80412052
5Base excision repair_Homo sapiens_hsa034102.59186810
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48845359
7Cell cycle_Homo sapiens_hsa041102.46831903
8RNA transport_Homo sapiens_hsa030132.36872487
9Nucleotide excision repair_Homo sapiens_hsa034202.34814491
10Proteasome_Homo sapiens_hsa030502.31719481
11Homologous recombination_Homo sapiens_hsa034402.22462833
12Non-homologous end-joining_Homo sapiens_hsa034502.05205638
13RNA polymerase_Homo sapiens_hsa030201.82202498
14One carbon pool by folate_Homo sapiens_hsa006701.73982176
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73024362
16p53 signaling pathway_Homo sapiens_hsa041151.70299533
17Pyrimidine metabolism_Homo sapiens_hsa002401.66889270
18Primary immunodeficiency_Homo sapiens_hsa053401.66294795
19Fanconi anemia pathway_Homo sapiens_hsa034601.59726695
20RNA degradation_Homo sapiens_hsa030181.57688863
21Systemic lupus erythematosus_Homo sapiens_hsa053221.56071356
22Antigen processing and presentation_Homo sapiens_hsa046121.53079414
23mRNA surveillance pathway_Homo sapiens_hsa030151.39914053
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38071213
25Viral carcinogenesis_Homo sapiens_hsa052031.37123562
26Sulfur relay system_Homo sapiens_hsa041221.36204497
27Herpes simplex infection_Homo sapiens_hsa051681.30568852
28Epstein-Barr virus infection_Homo sapiens_hsa051691.26858876
29Autoimmune thyroid disease_Homo sapiens_hsa053201.23714654
30Small cell lung cancer_Homo sapiens_hsa052221.17366350
31HTLV-I infection_Homo sapiens_hsa051661.16828637
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13641295
33Measles_Homo sapiens_hsa051621.12518758
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08492242
35Shigellosis_Homo sapiens_hsa051311.08277226
36Other glycan degradation_Homo sapiens_hsa005111.07932247
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.07569897
38Basal transcription factors_Homo sapiens_hsa030221.06975712
39Pentose phosphate pathway_Homo sapiens_hsa000301.05534180
40Legionellosis_Homo sapiens_hsa051341.05162118
41Chronic myeloid leukemia_Homo sapiens_hsa052201.04957628
42Hematopoietic cell lineage_Homo sapiens_hsa046401.04285740
43MicroRNAs in cancer_Homo sapiens_hsa052061.02439479
44Viral myocarditis_Homo sapiens_hsa054161.01637839
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01526423
46Leishmaniasis_Homo sapiens_hsa051400.99519369
47Apoptosis_Homo sapiens_hsa042100.97588692
48Hepatitis B_Homo sapiens_hsa051610.96672520
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.93691715
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92923831
51Colorectal cancer_Homo sapiens_hsa052100.89348834
52B cell receptor signaling pathway_Homo sapiens_hsa046620.88999662
53Parkinsons disease_Homo sapiens_hsa050120.87890507
54Oxidative phosphorylation_Homo sapiens_hsa001900.87244005
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84817911
56T cell receptor signaling pathway_Homo sapiens_hsa046600.83952438
57Thyroid cancer_Homo sapiens_hsa052160.83901755
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83155886
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77072186
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.75986356
61Pancreatic cancer_Homo sapiens_hsa052120.75105675
62Biosynthesis of amino acids_Homo sapiens_hsa012300.73805225
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73445396
64Purine metabolism_Homo sapiens_hsa002300.72824821
65Toxoplasmosis_Homo sapiens_hsa051450.72714073
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72603479
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70434650
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69952832
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69948002
70N-Glycan biosynthesis_Homo sapiens_hsa005100.69790936
71Huntingtons disease_Homo sapiens_hsa050160.69006214
72Alcoholism_Homo sapiens_hsa050340.68327246
73Protein export_Homo sapiens_hsa030600.68170901
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66781102
75Osteoclast differentiation_Homo sapiens_hsa043800.66467156
76Allograft rejection_Homo sapiens_hsa053300.66088136
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65199693
78Acute myeloid leukemia_Homo sapiens_hsa052210.64547492
79TGF-beta signaling pathway_Homo sapiens_hsa043500.64327381
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64020138
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63972025
82Type I diabetes mellitus_Homo sapiens_hsa049400.62186294
83Adherens junction_Homo sapiens_hsa045200.62081786
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.61351151
85Influenza A_Homo sapiens_hsa051640.60268856
86Proteoglycans in cancer_Homo sapiens_hsa052050.59925136
87Sulfur metabolism_Homo sapiens_hsa009200.59883719
88Asthma_Homo sapiens_hsa053100.59201281
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59116229
90Oocyte meiosis_Homo sapiens_hsa041140.58713589
91Carbon metabolism_Homo sapiens_hsa012000.58096273
92Rheumatoid arthritis_Homo sapiens_hsa053230.57718952
93Fatty acid elongation_Homo sapiens_hsa000620.56481853
94Non-small cell lung cancer_Homo sapiens_hsa052230.55891160
95Bladder cancer_Homo sapiens_hsa052190.55799681
96Graft-versus-host disease_Homo sapiens_hsa053320.55709172
97Glutathione metabolism_Homo sapiens_hsa004800.54792242
98TNF signaling pathway_Homo sapiens_hsa046680.52308151
99Platelet activation_Homo sapiens_hsa046110.51984064
100Notch signaling pathway_Homo sapiens_hsa043300.51813629
101Pathways in cancer_Homo sapiens_hsa052000.51364347
102Selenocompound metabolism_Homo sapiens_hsa004500.51344966
103Folate biosynthesis_Homo sapiens_hsa007900.49536174
104Focal adhesion_Homo sapiens_hsa045100.49427935
105Prostate cancer_Homo sapiens_hsa052150.48851221
106Hepatitis C_Homo sapiens_hsa051600.48289055
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46905123
108Malaria_Homo sapiens_hsa051440.46635599
109ECM-receptor interaction_Homo sapiens_hsa045120.46236861
110Salmonella infection_Homo sapiens_hsa051320.45932376
111Lysosome_Homo sapiens_hsa041420.45384484
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.44705874
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.44693120
114Pertussis_Homo sapiens_hsa051330.44544009
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.44023597
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42656937
117Hippo signaling pathway_Homo sapiens_hsa043900.42479660
118HIF-1 signaling pathway_Homo sapiens_hsa040660.42375242
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42286012
120Basal cell carcinoma_Homo sapiens_hsa052170.40137425
121Tuberculosis_Homo sapiens_hsa051520.39094794
122mTOR signaling pathway_Homo sapiens_hsa041500.37809007
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37402638

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