

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | histone H3-K4 trimethylation (GO:0080182) | 4.97131299 |
| 2 | pre-miRNA processing (GO:0031054) | 4.66705363 |
| 3 | histone H3-K4 methylation (GO:0051568) | 4.60575902 |
| 4 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.29632697 |
| 5 | positive regulation of granulocyte differentiation (GO:0030854) | 4.08523250 |
| 6 | negative regulation of cell killing (GO:0031342) | 3.92199286 |
| 7 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.92199286 |
| 8 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.86027070 |
| 9 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.84742838 |
| 10 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.83726097 |
| 11 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.76625199 |
| 12 | response to muramyl dipeptide (GO:0032495) | 3.73534106 |
| 13 | positive regulation of histone deacetylation (GO:0031065) | 3.73519433 |
| 14 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.71296734 |
| 15 | peptidyl-lysine trimethylation (GO:0018023) | 3.70249467 |
| 16 | histone lysine methylation (GO:0034968) | 3.65156896 |
| 17 | mitotic sister chromatid cohesion (GO:0007064) | 3.60745219 |
| 18 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.54763360 |
| 19 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.51657069 |
| 20 | negative regulation of histone methylation (GO:0031061) | 3.49738860 |
| 21 | histone H3-K36 demethylation (GO:0070544) | 3.48154158 |
| 22 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.48097141 |
| 23 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.42474896 |
| 24 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.42474896 |
| 25 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.42474896 |
| 26 | regulation of gamma-delta T cell activation (GO:0046643) | 3.42286785 |
| 27 | positive regulation by symbiont of host defense response (GO:0052509) | 3.42063180 |
| 28 | modulation by symbiont of host defense response (GO:0052031) | 3.42063180 |
| 29 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.42063180 |
| 30 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.42063180 |
| 31 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.42063180 |
| 32 | modulation by symbiont of host immune response (GO:0052553) | 3.42063180 |
| 33 | positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145) | 3.33945774 |
| 34 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.33021166 |
| 35 | cellular extravasation (GO:0045123) | 3.30513011 |
| 36 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.24442174 |
| 37 | activated T cell proliferation (GO:0050798) | 3.21283919 |
| 38 | positive thymic T cell selection (GO:0045059) | 3.20373815 |
| 39 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.16969577 |
| 40 | regulation of granulocyte differentiation (GO:0030852) | 3.12617913 |
| 41 | NLS-bearing protein import into nucleus (GO:0006607) | 3.12155277 |
| 42 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.11821285 |
| 43 | dosage compensation (GO:0007549) | 3.11556134 |
| 44 | detection of other organism (GO:0098543) | 3.09378964 |
| 45 | negative thymic T cell selection (GO:0045060) | 3.09200147 |
| 46 | negative T cell selection (GO:0043383) | 3.09193270 |
| 47 | peptidyl-lysine methylation (GO:0018022) | 3.08677413 |
| 48 | histone H4-K16 acetylation (GO:0043984) | 3.06778754 |
| 49 | negative regulation of T cell mediated immunity (GO:0002710) | 3.06274681 |
| 50 | positive T cell selection (GO:0043368) | 3.05615839 |
| 51 | regulation of histone H3-K27 methylation (GO:0061085) | 3.03956627 |
| 52 | thymic T cell selection (GO:0045061) | 3.02998982 |
| 53 | T cell selection (GO:0045058) | 3.02250040 |
| 54 | histone methylation (GO:0016571) | 3.01418013 |
| 55 | detection of molecule of bacterial origin (GO:0032490) | 3.01382811 |
| 56 | histone H3-K9 demethylation (GO:0033169) | 2.99887092 |
| 57 | germinal center formation (GO:0002467) | 2.99687947 |
| 58 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.99570059 |
| 59 | stress granule assembly (GO:0034063) | 2.99219890 |
| 60 | detection of bacterium (GO:0016045) | 2.96473220 |
| 61 | negative regulation of myotube differentiation (GO:0010832) | 2.94999353 |
| 62 | regulation of ARF protein signal transduction (GO:0032012) | 2.94128434 |
| 63 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.93883230 |
| 64 | leukocyte aggregation (GO:0070486) | 2.93163502 |
| 65 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.91903017 |
| 66 | macrophage activation involved in immune response (GO:0002281) | 2.89313353 |
| 67 | mRNA splice site selection (GO:0006376) | 2.88768746 |
| 68 | detection of external biotic stimulus (GO:0098581) | 2.86936514 |
| 69 | regulation of intracellular estrogen receptor signaling pathway (GO:0033146) | 2.84710384 |
| 70 | peptidyl-lysine dimethylation (GO:0018027) | 2.82817302 |
| 71 | T cell migration (GO:0072678) | 2.82422410 |
| 72 | positive regulation of protein deacetylation (GO:0090312) | 2.82300600 |
| 73 | mannose metabolic process (GO:0006013) | 2.81440802 |
| 74 | dicarboxylic acid biosynthetic process (GO:0043650) | 2.78249648 |
| 75 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.77586746 |
| 76 | regulation of histone H3-K4 methylation (GO:0051569) | 2.77240626 |
| 77 | tolerance induction (GO:0002507) | 2.76671698 |
| 78 | histone H3-K9 modification (GO:0061647) | 2.76457981 |
| 79 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.74819888 |
| 80 | regulation of B cell differentiation (GO:0045577) | 2.74334196 |
| 81 | cellular response to ethanol (GO:0071361) | 2.71619322 |
| 82 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.70109797 |
| 83 | histone lysine demethylation (GO:0070076) | 2.69560452 |
| 84 | regulation of RNA export from nucleus (GO:0046831) | 2.69020895 |
| 85 | regulation of necroptotic process (GO:0060544) | 2.68961298 |
| 86 | B cell homeostasis (GO:0001782) | 2.67727785 |
| 87 | intracellular estrogen receptor signaling pathway (GO:0030520) | 2.67398715 |
| 88 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.67300588 |
| 89 | regulation of histone methylation (GO:0031060) | 2.66654400 |
| 90 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.64644267 |
| 91 | Peyers patch development (GO:0048541) | 2.64644267 |
| 92 | neutrophil mediated immunity (GO:0002446) | 2.64436094 |
| 93 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.63337993 |
| 94 | histone H3-K9 methylation (GO:0051567) | 2.63027411 |
| 95 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.62877254 |
| 96 | establishment of protein localization to Golgi (GO:0072600) | 2.61890922 |
| 97 | regulation of ARF GTPase activity (GO:0032312) | 2.61738751 |
| 98 | microglial cell activation (GO:0001774) | 2.61043173 |
| 99 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.60775608 |
| 100 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.59559726 |
| 101 | cellular response to interleukin-15 (GO:0071350) | 2.58949283 |
| 102 | mRNA stabilization (GO:0048255) | 2.58481560 |
| 103 | RNA stabilization (GO:0043489) | 2.58481560 |
| 104 | nuclear pore complex assembly (GO:0051292) | 2.58131316 |
| 105 | T cell homeostasis (GO:0043029) | 2.56751345 |
| 106 | interkinetic nuclear migration (GO:0022027) | 2.55975721 |
| 107 | histone demethylation (GO:0016577) | 2.53578165 |
| 108 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.53459955 |
| 109 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.53354743 |
| 110 | detection of biotic stimulus (GO:0009595) | 2.51909969 |
| 111 | protein-DNA complex disassembly (GO:0032986) | 2.50917891 |
| 112 | nucleosome disassembly (GO:0006337) | 2.50917891 |
| 113 | positive regulation of RNA splicing (GO:0033120) | 2.50022647 |
| 114 | histone deubiquitination (GO:0016578) | 2.49691787 |
| 115 | negative regulation of cell size (GO:0045792) | 2.49028042 |
| 116 | protein targeting to Golgi (GO:0000042) | 2.48090169 |
| 117 | positive regulation of B cell differentiation (GO:0045579) | 2.47746371 |
| 118 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.47481461 |
| 119 | myeloid leukocyte mediated immunity (GO:0002444) | 2.47362677 |
| 120 | positive regulation of CREB transcription factor activity (GO:0032793) | 2.47283318 |
| 121 | response to interleukin-15 (GO:0070672) | 2.47081409 |
| 122 | regulation of histone deacetylation (GO:0031063) | 2.46385183 |
| 123 | activation of JUN kinase activity (GO:0007257) | 2.46342758 |
| 124 | chromatin silencing (GO:0006342) | 2.44788620 |
| 125 | response to host immune response (GO:0052572) | 2.44631234 |
| 126 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.44631234 |
| 127 | peptidyl-threonine phosphorylation (GO:0018107) | 2.44288953 |
| 128 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.44036011 |
| 129 | histone H4 acetylation (GO:0043967) | 2.43994398 |
| 130 | regulation of regulatory T cell differentiation (GO:0045589) | 2.42795190 |
| 131 | positive regulation of Rap GTPase activity (GO:0032854) | 2.38993723 |
| 132 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.37711618 |
| 133 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO | 2.37353820 |
| 134 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) | 2.37353820 |
| 135 | positive regulation of mRNA catabolic process (GO:0061014) | 2.36768977 |
| 136 | B cell receptor signaling pathway (GO:0050853) | 2.35930159 |
| 137 | embryonic hemopoiesis (GO:0035162) | 2.34841140 |
| 138 | regulation of protein deacetylation (GO:0090311) | 2.34625952 |
| 139 | protein dealkylation (GO:0008214) | 2.34319431 |
| 140 | protein demethylation (GO:0006482) | 2.34319431 |
| 141 | regulation of histone H3-K9 methylation (GO:0051570) | 2.33246393 |
| 142 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.33165515 |
| 143 | regulation of chromatin binding (GO:0035561) | 2.32520247 |
| 144 | negative regulation of RNA splicing (GO:0033119) | 2.31933469 |
| 145 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.29436295 |
| 146 | regulation of mRNA catabolic process (GO:0061013) | 2.29080777 |
| 147 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.27476462 |
| 148 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.27373356 |
| 149 | histone mRNA catabolic process (GO:0071044) | 2.26917477 |
| 150 | peptidyl-threonine modification (GO:0018210) | 2.26100653 |
| 151 | regulation of cholesterol homeostasis (GO:2000188) | 2.25623948 |
| 152 | negative regulation of mRNA processing (GO:0050686) | 2.25178158 |
| 153 | histone H4-K8 acetylation (GO:0043982) | 2.23414780 |
| 154 | histone H4-K5 acetylation (GO:0043981) | 2.23414780 |
| 155 | regulation of DNA endoreduplication (GO:0032875) | 2.23402997 |
| 156 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.21896648 |
| 157 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.21896648 |
| 158 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.21896648 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_22102868_ChIP-Seq_BL_Human | 4.31361032 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.89085636 |
| 3 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.82248778 |
| 4 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.65825505 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.17917652 |
| 6 | TCF7_22412390_ChIP-Seq_EML_Mouse | 3.08060152 |
| 7 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.93272916 |
| 8 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.90085091 |
| 9 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.82244184 |
| 10 | KDM2B_26808549_Chip-Seq_DND41_Human | 2.81221418 |
| 11 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.58567116 |
| 12 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.51212183 |
| 13 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.48264485 |
| 14 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.47594513 |
| 15 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.41346552 |
| 16 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.20427037 |
| 17 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 2.19415348 |
| 18 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.18388053 |
| 19 | UTX_26944678_Chip-Seq_JUKART_Human | 2.16525505 |
| 20 | MAF_26560356_Chip-Seq_TH1_Human | 2.09121600 |
| 21 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 2.02427111 |
| 22 | KDM2B_26808549_Chip-Seq_K562_Human | 1.96784297 |
| 23 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.96702781 |
| 24 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.93414679 |
| 25 | * CIITA_25753668_ChIP-Seq_RAJI_Human | 1.85862992 |
| 26 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.85791099 |
| 27 | MYB_26560356_Chip-Seq_TH1_Human | 1.83920861 |
| 28 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.71254846 |
| 29 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.65170396 |
| 30 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.64887514 |
| 31 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.64845754 |
| 32 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.63773695 |
| 33 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.62986643 |
| 34 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.62646915 |
| 35 | * MYB_26560356_Chip-Seq_TH2_Human | 1.58959152 |
| 36 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.58225340 |
| 37 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.55877975 |
| 38 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.53562074 |
| 39 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.52868791 |
| 40 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.50691519 |
| 41 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.49389110 |
| 42 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.49369507 |
| 43 | SPI1_23127762_ChIP-Seq_K562_Human | 1.49244669 |
| 44 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.48593275 |
| 45 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.47240867 |
| 46 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.47015144 |
| 47 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.43640369 |
| 48 | GATA1_19941826_ChIP-Seq_K562_Human | 1.39945574 |
| 49 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.39872981 |
| 50 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.38283000 |
| 51 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.36501995 |
| 52 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.35162570 |
| 53 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.34777957 |
| 54 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.33820505 |
| 55 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.33115482 |
| 56 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.32439356 |
| 57 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.31787244 |
| 58 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.31632570 |
| 59 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.31438586 |
| 60 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.28551254 |
| 61 | * NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.27690752 |
| 62 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.27331236 |
| 63 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.25835855 |
| 64 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.25092950 |
| 65 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.24768450 |
| 66 | MAF_26560356_Chip-Seq_TH2_Human | 1.24633891 |
| 67 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.23601394 |
| 68 | GATA1_22025678_ChIP-Seq_K562_Human | 1.23358858 |
| 69 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.21631499 |
| 70 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.21249170 |
| 71 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.18224754 |
| 72 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.17951521 |
| 73 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.17126463 |
| 74 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.16788939 |
| 75 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.16752015 |
| 76 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.16040200 |
| 77 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.15364747 |
| 78 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.15212314 |
| 79 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14024174 |
| 80 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.13596551 |
| 81 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13325432 |
| 82 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.12528991 |
| 83 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.11467777 |
| 84 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10524476 |
| 85 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.09987125 |
| 86 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.08715620 |
| 87 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08471677 |
| 88 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.05126753 |
| 89 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02309416 |
| 90 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.01482644 |
| 91 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.01116507 |
| 92 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.01090572 |
| 93 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.00860379 |
| 94 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.00077276 |
| 95 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.99460959 |
| 96 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.98735426 |
| 97 | GATA2_19941826_ChIP-Seq_K562_Human | 0.96035709 |
| 98 | TP53_16413492_ChIP-PET_HCT116_Human | 0.95954346 |
| 99 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.95497842 |
| 100 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.93877373 |
| 101 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.91585375 |
| 102 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.90404407 |
| 103 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.89720311 |
| 104 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.88346627 |
| 105 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.87936887 |
| 106 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.87242222 |
| 107 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.86511273 |
| 108 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.86338422 |
| 109 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86027364 |
| 110 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.85923441 |
| 111 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.85728100 |
| 112 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85288256 |
| 113 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.84722152 |
| 114 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.84680007 |
| 115 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.84567955 |
| 116 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.84040927 |
| 117 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.83968673 |
| 118 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83178628 |
| 119 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.82976948 |
| 120 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.81005035 |
| 121 | GATA3_26560356_Chip-Seq_TH2_Human | 0.76671892 |
| 122 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.75590498 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 4.52668519 |
| 2 | MP0005076_abnormal_cell_differentiation | 2.94818907 |
| 3 | MP0008961_abnormal_basal_metabolism | 2.90661096 |
| 4 | MP0003787_abnormal_imprinting | 2.70190721 |
| 5 | MP0001835_abnormal_antigen_presentation | 2.61417167 |
| 6 | MP0003300_gastrointestinal_ulcer | 2.59987821 |
| 7 | MP0003763_abnormal_thymus_physiology | 2.57753627 |
| 8 | MP0009278_abnormal_bone_marrow | 2.39901501 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.35495764 |
| 10 | MP0003724_increased_susceptibility_to | 2.34739855 |
| 11 | MP0004808_abnormal_hematopoietic_stem | 2.33047440 |
| 12 | MP0008260_abnormal_autophagy | 2.28549459 |
| 13 | MP0002166_altered_tumor_susceptibility | 2.22478413 |
| 14 | MP0004381_abnormal_hair_follicle | 2.16235492 |
| 15 | MP0004859_abnormal_synaptic_plasticity | 2.16140673 |
| 16 | MP0005451_abnormal_body_composition | 2.09738715 |
| 17 | MP0003303_peritoneal_inflammation | 2.09323022 |
| 18 | MP0003705_abnormal_hypodermis_morpholog | 2.03657439 |
| 19 | MP0005000_abnormal_immune_tolerance | 1.95802570 |
| 20 | MP0003252_abnormal_bile_duct | 1.93348169 |
| 21 | MP0000703_abnormal_thymus_morphology | 1.92554988 |
| 22 | MP0002398_abnormal_bone_marrow | 1.91163428 |
| 23 | MP0003172_abnormal_lysosome_physiology | 1.91102879 |
| 24 | MP0002419_abnormal_innate_immunity | 1.84382254 |
| 25 | MP0001800_abnormal_humoral_immune | 1.83674072 |
| 26 | MP0010352_gastrointestinal_tract_polyps | 1.80326371 |
| 27 | MP0001873_stomach_inflammation | 1.79688488 |
| 28 | MP0005397_hematopoietic_system_phenotyp | 1.79078560 |
| 29 | MP0001545_abnormal_hematopoietic_system | 1.79078560 |
| 30 | MP0005365_abnormal_bile_salt | 1.77661678 |
| 31 | MP0005025_abnormal_response_to | 1.73100411 |
| 32 | MP0010307_abnormal_tumor_latency | 1.71637264 |
| 33 | MP0003111_abnormal_nucleus_morphology | 1.65669960 |
| 34 | MP0005409_darkened_coat_color | 1.62916348 |
| 35 | MP0000685_abnormal_immune_system | 1.60540240 |
| 36 | MP0008995_early_reproductive_senescence | 1.59312365 |
| 37 | MP0002009_preneoplasia | 1.57632507 |
| 38 | MP0008057_abnormal_DNA_replication | 1.56640765 |
| 39 | MP0002139_abnormal_hepatobiliary_system | 1.50682988 |
| 40 | MP0002928_abnormal_bile_duct | 1.49959690 |
| 41 | MP0004130_abnormal_muscle_cell | 1.49128946 |
| 42 | MP0002006_tumorigenesis | 1.46518208 |
| 43 | MP0003868_abnormal_feces_composition | 1.44294007 |
| 44 | MP0009672_abnormal_birth_weight | 1.41965132 |
| 45 | MP0002722_abnormal_immune_system | 1.41876287 |
| 46 | MP0003828_pulmonary_edema | 1.41649709 |
| 47 | MP0000689_abnormal_spleen_morphology | 1.38216343 |
| 48 | MP0010094_abnormal_chromosome_stability | 1.35221689 |
| 49 | MP0001851_eye_inflammation | 1.34112991 |
| 50 | MP0009703_decreased_birth_body | 1.33983073 |
| 51 | MP0005310_abnormal_salivary_gland | 1.32375517 |
| 52 | MP0004185_abnormal_adipocyte_glucose | 1.31557245 |
| 53 | MP0000716_abnormal_immune_system | 1.30453153 |
| 54 | MP0008569_lethality_at_weaning | 1.26735587 |
| 55 | MP0000733_abnormal_muscle_development | 1.26325839 |
| 56 | MP0003091_abnormal_cell_migration | 1.25427140 |
| 57 | MP0003045_fibrosis | 1.24271621 |
| 58 | MP0004197_abnormal_fetal_growth/weight/ | 1.24179774 |
| 59 | MP0005387_immune_system_phenotype | 1.23714124 |
| 60 | MP0001790_abnormal_immune_system | 1.23714124 |
| 61 | MP0005174_abnormal_tail_pigmentation | 1.23476597 |
| 62 | MP0005360_urolithiasis | 1.23184813 |
| 63 | MP0000465_gastrointestinal_hemorrhage | 1.21879551 |
| 64 | MP0003866_abnormal_defecation | 1.21708075 |
| 65 | MP0010234_abnormal_vibrissa_follicle | 1.21429653 |
| 66 | MP0003221_abnormal_cardiomyocyte_apopto | 1.18815821 |
| 67 | MP0003077_abnormal_cell_cycle | 1.17833833 |
| 68 | MP0003690_abnormal_glial_cell | 1.17324614 |
| 69 | MP0005671_abnormal_response_to | 1.16970352 |
| 70 | MP0005670_abnormal_white_adipose | 1.16690574 |
| 71 | MP0010155_abnormal_intestine_physiology | 1.15461957 |
| 72 | MP0000609_abnormal_liver_physiology | 1.15439920 |
| 73 | MP0005083_abnormal_biliary_tract | 1.14688561 |
| 74 | MP0003656_abnormal_erythrocyte_physiolo | 1.14550117 |
| 75 | MP0003890_abnormal_embryonic-extraembry | 1.12298170 |
| 76 | MP0003183_abnormal_peptide_metabolism | 1.11775093 |
| 77 | MP0000003_abnormal_adipose_tissue | 1.10346844 |
| 78 | MP0000350_abnormal_cell_proliferation | 1.10323497 |
| 79 | MP0002452_abnormal_antigen_presenting | 1.09540509 |
| 80 | MP0002420_abnormal_adaptive_immunity | 1.08815052 |
| 81 | MP0002086_abnormal_extraembryonic_tissu | 1.08585293 |
| 82 | MP0002429_abnormal_blood_cell | 1.07347202 |
| 83 | MP0002723_abnormal_immune_serum | 1.07102951 |
| 84 | MP0005375_adipose_tissue_phenotype | 1.06922982 |
| 85 | MP0003984_embryonic_growth_retardation | 1.05852858 |
| 86 | MP0001819_abnormal_immune_cell | 1.05294875 |
| 87 | MP0002088_abnormal_embryonic_growth/wei | 1.04828098 |
| 88 | MP0009115_abnormal_fat_cell | 1.03603150 |
| 89 | MP0005666_abnormal_adipose_tissue | 1.02544425 |
| 90 | MP0001849_ear_inflammation | 1.02523721 |
| 91 | MP0008770_decreased_survivor_rate | 1.01594552 |
| 92 | MP0005380_embryogenesis_phenotype | 1.00141009 |
| 93 | MP0001672_abnormal_embryogenesis/_devel | 1.00141009 |
| 94 | MP0002998_abnormal_bone_remodeling | 0.99823022 |
| 95 | MP0002089_abnormal_postnatal_growth/wei | 0.97929375 |
| 96 | MP0002084_abnormal_developmental_patter | 0.97312549 |
| 97 | MP0008877_abnormal_DNA_methylation | 0.93225220 |
| 98 | MP0002019_abnormal_tumor_incidence | 0.92682310 |
| 99 | MP0009333_abnormal_splenocyte_physiolog | 0.92493053 |
| 100 | MP0002405_respiratory_system_inflammati | 0.92003066 |
| 101 | MP0004947_skin_inflammation | 0.90573164 |
| 102 | MP0002925_abnormal_cardiovascular_devel | 0.90080507 |
| 103 | MP0005621_abnormal_cell_physiology | 0.89835600 |
| 104 | MP0006292_abnormal_olfactory_placode | 0.89164215 |
| 105 | MP0002970_abnormal_white_adipose | 0.88370564 |
| 106 | MP0002971_abnormal_brown_adipose | 0.87206955 |
| 107 | MP0002132_abnormal_respiratory_system | 0.85800344 |
| 108 | MP0000490_abnormal_crypts_of | 0.85383044 |
| 109 | MP0004264_abnormal_extraembryonic_tissu | 0.85227533 |
| 110 | MP0002877_abnormal_melanocyte_morpholog | 0.83278324 |
| 111 | MP0005334_abnormal_fat_pad | 0.83252399 |
| 112 | MP0000015_abnormal_ear_pigmentation | 0.81903973 |
| 113 | MP0008007_abnormal_cellular_replicative | 0.81696615 |
| 114 | MP0003115_abnormal_respiratory_system | 0.81668141 |
| 115 | MP0010630_abnormal_cardiac_muscle | 0.81579072 |
| 116 | MP0001845_abnormal_inflammatory_respons | 0.81543762 |
| 117 | MP0009785_altered_susceptibility_to | 0.81097847 |
| 118 | MP0003935_abnormal_craniofacial_develop | 0.80265027 |
| 119 | MP0001533_abnormal_skeleton_physiology | 0.79816454 |
| 120 | MP0000371_diluted_coat_color | 0.79487237 |
| 121 | MP0010329_abnormal_lipoprotein_level | 0.79057974 |
| 122 | MP0003121_genomic_imprinting | 0.78977545 |
| 123 | MP0001915_intracranial_hemorrhage | 0.78889819 |
| 124 | MP0005085_abnormal_gallbladder_physiolo | 0.78700716 |
| 125 | MP0005464_abnormal_platelet_physiology | 0.78212030 |
| 126 | MP0009780_abnormal_chondrocyte_physiolo | 0.78204542 |
| 127 | MP0000428_abnormal_craniofacial_morphol | 0.78063850 |
| 128 | MP0003436_decreased_susceptibility_to | 0.77353586 |
| 129 | MP0002085_abnormal_embryonic_tissue | 0.76252165 |
| 130 | MP0003122_maternal_imprinting | 0.71074143 |
| 131 | MP0004510_myositis | 0.71047303 |
| 132 | MP0002822_catalepsy | 0.67654510 |
| 133 | MP0004883_abnormal_blood_vessel | 0.67310657 |
| 134 | MP0002933_joint_inflammation | 0.66856669 |
| 135 | MP0004484_altered_response_of | 0.64933211 |
| 136 | MP0000858_altered_metastatic_potential | 0.64687585 |
| 137 | MP0002249_abnormal_larynx_morphology | 0.64504873 |
| 138 | MP0001853_heart_inflammation | 0.64368273 |
| 139 | MP0003191_abnormal_cellular_cholesterol | 0.61782802 |
| 140 | MP0005075_abnormal_melanosome_morpholog | 0.60406871 |
| 141 | MP0003632_abnormal_nervous_system | 0.59016041 |
| 142 | MP0002332_abnormal_exercise_endurance | 0.58759727 |
| 143 | MP0002138_abnormal_hepatobiliary_system | 0.55342482 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the fingertips (HP:0001211) | 4.93155287 |
| 2 | Eczematoid dermatitis (HP:0000976) | 4.02735870 |
| 3 | Hyperacusis (HP:0010780) | 3.42379734 |
| 4 | Recurrent bacterial skin infections (HP:0005406) | 3.32578038 |
| 5 | Macroorchidism (HP:0000053) | 3.21871997 |
| 6 | Narrow palate (HP:0000189) | 2.98884808 |
| 7 | Heterotopia (HP:0002282) | 2.93240822 |
| 8 | Recurrent abscess formation (HP:0002722) | 2.89388826 |
| 9 | Spontaneous hematomas (HP:0007420) | 2.85481118 |
| 10 | Obstructive sleep apnea (HP:0002870) | 2.82473100 |
| 11 | Volvulus (HP:0002580) | 2.80380703 |
| 12 | Elfin facies (HP:0004428) | 2.79082278 |
| 13 | Gastrointestinal infarctions (HP:0005244) | 2.76693293 |
| 14 | Long eyelashes (HP:0000527) | 2.74129683 |
| 15 | Slow saccadic eye movements (HP:0000514) | 2.68481820 |
| 16 | Obsessive-compulsive behavior (HP:0000722) | 2.68059044 |
| 17 | Renovascular hypertension (HP:0100817) | 2.66671515 |
| 18 | Gingivitis (HP:0000230) | 2.59998932 |
| 19 | Dysmetric saccades (HP:0000641) | 2.57937202 |
| 20 | Myositis (HP:0100614) | 2.57724627 |
| 21 | Hypochromic microcytic anemia (HP:0004840) | 2.57070029 |
| 22 | Trigonocephaly (HP:0000243) | 2.56534189 |
| 23 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.47439026 |
| 24 | Short 4th metacarpal (HP:0010044) | 2.47439026 |
| 25 | Increased IgE level (HP:0003212) | 2.46477761 |
| 26 | Meningitis (HP:0001287) | 2.43508023 |
| 27 | Genetic anticipation (HP:0003743) | 2.42846830 |
| 28 | Papilledema (HP:0001085) | 2.41495364 |
| 29 | Acute lymphatic leukemia (HP:0006721) | 2.38778885 |
| 30 | Dislocated radial head (HP:0003083) | 2.34504421 |
| 31 | Insomnia (HP:0100785) | 2.34402048 |
| 32 | Hemiplegia (HP:0002301) | 2.33709459 |
| 33 | Deep palmar crease (HP:0006191) | 2.31728848 |
| 34 | Mediastinal lymphadenopathy (HP:0100721) | 2.27111715 |
| 35 | Recurrent cutaneous fungal infections (HP:0011370) | 2.25743387 |
| 36 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.25743387 |
| 37 | Pointed chin (HP:0000307) | 2.24560506 |
| 38 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.22993254 |
| 39 | Poikilocytosis (HP:0004447) | 2.21721232 |
| 40 | Granulocytopenia (HP:0001913) | 2.21109006 |
| 41 | Abnormality of the columella (HP:0009929) | 2.20180898 |
| 42 | Viral hepatitis (HP:0006562) | 2.20044350 |
| 43 | Increased nuchal translucency (HP:0010880) | 2.20023253 |
| 44 | Anal stenosis (HP:0002025) | 2.17793904 |
| 45 | Recurrent skin infections (HP:0001581) | 2.17326572 |
| 46 | Chest pain (HP:0100749) | 2.17116896 |
| 47 | Abnormality of the radial head (HP:0003995) | 2.16677530 |
| 48 | Abnormality of T cells (HP:0002843) | 2.16674086 |
| 49 | Cerebral aneurysm (HP:0004944) | 2.16667791 |
| 50 | Retrobulbar optic neuritis (HP:0100654) | 2.16617100 |
| 51 | Optic neuritis (HP:0100653) | 2.16617100 |
| 52 | Vertebral arch anomaly (HP:0008438) | 2.14309994 |
| 53 | Impaired smooth pursuit (HP:0007772) | 2.14304199 |
| 54 | Depressed nasal tip (HP:0000437) | 2.13167283 |
| 55 | Neonatal hypoglycemia (HP:0001998) | 2.12171407 |
| 56 | Orchitis (HP:0100796) | 2.11572417 |
| 57 | Urethral obstruction (HP:0000796) | 2.10794708 |
| 58 | Truncal obesity (HP:0001956) | 2.10019234 |
| 59 | T lymphocytopenia (HP:0005403) | 2.08919160 |
| 60 | Absent frontal sinuses (HP:0002688) | 2.08753691 |
| 61 | Vasculitis (HP:0002633) | 2.08695221 |
| 62 | Panhypogammaglobulinemia (HP:0003139) | 2.07109980 |
| 63 | Prominent nose (HP:0000448) | 2.06648142 |
| 64 | Difficulty running (HP:0009046) | 2.06289531 |
| 65 | Hypoplasia of the thymus (HP:0000778) | 2.05924515 |
| 66 | Thyroiditis (HP:0100646) | 2.05695112 |
| 67 | Recurrent viral infections (HP:0004429) | 2.04506480 |
| 68 | Prolonged bleeding time (HP:0003010) | 2.03010718 |
| 69 | Leukocytosis (HP:0001974) | 2.02951481 |
| 70 | Transitional cell carcinoma of the bladder (HP:0006740) | 2.02717535 |
| 71 | Subaortic stenosis (HP:0001682) | 2.00946520 |
| 72 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.00946520 |
| 73 | Pustule (HP:0200039) | 2.00835198 |
| 74 | Colitis (HP:0002583) | 2.00764892 |
| 75 | Overriding aorta (HP:0002623) | 1.97212803 |
| 76 | Broad face (HP:0000283) | 1.96181811 |
| 77 | Agammaglobulinemia (HP:0004432) | 1.95338096 |
| 78 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.94100428 |
| 79 | Leiomyosarcoma (HP:0100243) | 1.93985856 |
| 80 | Uterine leiomyosarcoma (HP:0002891) | 1.93985856 |
| 81 | Verrucae (HP:0200043) | 1.93736027 |
| 82 | Papilloma (HP:0012740) | 1.93736027 |
| 83 | Renal duplication (HP:0000075) | 1.92202653 |
| 84 | Autoimmune thrombocytopenia (HP:0001973) | 1.90403674 |
| 85 | Papillary thyroid carcinoma (HP:0002895) | 1.88470847 |
| 86 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.88046416 |
| 87 | Eosinophilia (HP:0001880) | 1.87669675 |
| 88 | Lymphopenia (HP:0001888) | 1.87298957 |
| 89 | Hypochromic anemia (HP:0001931) | 1.85837639 |
| 90 | Hyperkalemia (HP:0002153) | 1.85338072 |
| 91 | Abnormality of T cell number (HP:0011839) | 1.84415559 |
| 92 | Increased density of long bones (HP:0006392) | 1.84413941 |
| 93 | Basal cell carcinoma (HP:0002671) | 1.84402929 |
| 94 | Lip pit (HP:0100267) | 1.84325249 |
| 95 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.83982306 |
| 96 | Encephalitis (HP:0002383) | 1.83270528 |
| 97 | Abnormality of incisor morphology (HP:0011063) | 1.82935252 |
| 98 | Bowel diverticulosis (HP:0005222) | 1.82416333 |
| 99 | Syringomyelia (HP:0003396) | 1.82035814 |
| 100 | Spinal cord lesions (HP:0100561) | 1.82035814 |
| 101 | Abnormality of eosinophils (HP:0001879) | 1.81585750 |
| 102 | Skin tags (HP:0010609) | 1.81507721 |
| 103 | Acute myeloid leukemia (HP:0004808) | 1.81297829 |
| 104 | Postural instability (HP:0002172) | 1.81231516 |
| 105 | Aqueductal stenosis (HP:0002410) | 1.79906665 |
| 106 | Abnormality of the astrocytes (HP:0100707) | 1.79406682 |
| 107 | Astrocytoma (HP:0009592) | 1.79406682 |
| 108 | Abnormality of macrophages (HP:0004311) | 1.78497649 |
| 109 | Cutis marmorata (HP:0000965) | 1.78407249 |
| 110 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.78334775 |
| 111 | Smooth philtrum (HP:0000319) | 1.78199509 |
| 112 | Obstructive lung disease (HP:0006536) | 1.78146067 |
| 113 | Chronic obstructive pulmonary disease (HP:0006510) | 1.78146067 |
| 114 | Gingival bleeding (HP:0000225) | 1.78067418 |
| 115 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.78023902 |
| 116 | Abnormality of the 4th metacarpal (HP:0010012) | 1.77928781 |
| 117 | Keratoconjunctivitis sicca (HP:0001097) | 1.77906458 |
| 118 | Tapered finger (HP:0001182) | 1.77757812 |
| 119 | Broad palm (HP:0001169) | 1.77041764 |
| 120 | Supernumerary ribs (HP:0005815) | 1.76714193 |
| 121 | Abnormality of the diencephalon (HP:0010662) | 1.76469193 |
| 122 | Low anterior hairline (HP:0000294) | 1.76121715 |
| 123 | Limited elbow extension (HP:0001377) | 1.75987437 |
| 124 | Cellulitis (HP:0100658) | 1.75601079 |
| 125 | Ependymoma (HP:0002888) | 1.75298187 |
| 126 | Subacute progressive viral hepatitis (HP:0006572) | 1.74848028 |
| 127 | B lymphocytopenia (HP:0010976) | 1.74387367 |
| 128 | Abnormality of B cell number (HP:0010975) | 1.74387367 |
| 129 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.74317777 |
| 130 | Thick eyebrow (HP:0000574) | 1.73957252 |
| 131 | Recurrent bronchitis (HP:0002837) | 1.73384659 |
| 132 | Bladder neoplasm (HP:0009725) | 1.72390418 |
| 133 | Bladder carcinoma (HP:0002862) | 1.72390418 |
| 134 | Fatigue (HP:0012378) | 1.71619386 |
| 135 | Sacral dimple (HP:0000960) | 1.71254641 |
| 136 | Stereotypic behavior (HP:0000733) | 1.71084062 |
| 137 | Neoplasm of the heart (HP:0100544) | 1.70295342 |
| 138 | Onion bulb formation (HP:0003383) | 1.70076407 |
| 139 | Pseudobulbar signs (HP:0002200) | 1.70036631 |
| 140 | Autoimmune hemolytic anemia (HP:0001890) | 1.69663549 |
| 141 | Lower limb amyotrophy (HP:0007210) | 1.69483499 |
| 142 | Stomatitis (HP:0010280) | 1.68949268 |
| 143 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.67715910 |
| 144 | Arterial thrombosis (HP:0004420) | 1.67356332 |
| 145 | Myocardial infarction (HP:0001658) | 1.67283259 |
| 146 | Abnormality of the peritoneum (HP:0002585) | 1.66950092 |
| 147 | Flat cornea (HP:0007720) | 1.66769641 |
| 148 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.66660139 |
| 149 | Inflammation of the large intestine (HP:0002037) | 1.65772135 |
| 150 | Epistaxis (HP:0000421) | 1.65753243 |
| 151 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.64696488 |
| 152 | Gastrointestinal carcinoma (HP:0002672) | 1.64696488 |
| 153 | Deep philtrum (HP:0002002) | 1.64495458 |
| 154 | Abnormality of the lower motor neuron (HP:0002366) | 1.64259992 |
| 155 | Reticulocytosis (HP:0001923) | 1.64223374 |
| 156 | Recurrent fungal infections (HP:0002841) | 1.64112658 |
| 157 | Distal lower limb amyotrophy (HP:0008944) | 1.63225968 |
| 158 | Long palpebral fissure (HP:0000637) | 1.63201417 |
| 159 | Neoplasm of the oral cavity (HP:0100649) | 1.61334523 |
| 160 | Gastrointestinal inflammation (HP:0004386) | 1.59979790 |
| 161 | Glioma (HP:0009733) | 1.57704668 |
| 162 | Sandal gap (HP:0001852) | 1.56967596 |
| 163 | Aortic aneurysm (HP:0004942) | 1.55802845 |
| 164 | Severe combined immunodeficiency (HP:0004430) | 1.55236236 |
| 165 | Shallow orbits (HP:0000586) | 1.54767779 |
| 166 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.53658232 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.14396983 |
| 2 | SIK2 | 3.44881496 |
| 3 | EEF2K | 3.20917713 |
| 4 | MAP3K10 | 3.02958305 |
| 5 | PRPF4B | 2.83452336 |
| 6 | BRD4 | 2.72290969 |
| 7 | RIPK4 | 2.61569336 |
| 8 | MAP4K1 | 2.30838703 |
| 9 | CAMK1G | 2.21604831 |
| 10 | CAMK1D | 2.02965834 |
| 11 | SIK1 | 1.95021581 |
| 12 | TRIB3 | 1.92503149 |
| 13 | BLK | 1.91918802 |
| 14 | NEK2 | 1.82106574 |
| 15 | MAP2K3 | 1.72552329 |
| 16 | PKN2 | 1.57869696 |
| 17 | RIPK1 | 1.55826194 |
| 18 | SGK3 | 1.53999543 |
| 19 | ERN1 | 1.51925846 |
| 20 | MAP3K7 | 1.47556706 |
| 21 | CDK6 | 1.46983353 |
| 22 | IRAK4 | 1.45005844 |
| 23 | ICK | 1.42518426 |
| 24 | STK38 | 1.39100719 |
| 25 | TAOK1 | 1.38002240 |
| 26 | MAP3K14 | 1.36940298 |
| 27 | STK10 | 1.35602832 |
| 28 | SGK2 | 1.25588996 |
| 29 | FGFR3 | 1.24017996 |
| 30 | PTK6 | 1.20254918 |
| 31 | CSK | 1.19885561 |
| 32 | MTOR | 1.19451715 |
| 33 | NLK | 1.18778989 |
| 34 | JAK1 | 1.18246396 |
| 35 | KSR2 | 1.15735938 |
| 36 | SGK494 | 1.14932100 |
| 37 | SGK223 | 1.14932100 |
| 38 | FGFR4 | 1.13366174 |
| 39 | MKNK2 | 1.08170982 |
| 40 | ALK | 1.07454137 |
| 41 | MARK2 | 1.07160926 |
| 42 | PRKCH | 1.04351881 |
| 43 | FGFR2 | 1.03035061 |
| 44 | LATS1 | 1.01281181 |
| 45 | HIPK2 | 1.00358921 |
| 46 | CDC42BPA | 0.99502197 |
| 47 | AKT3 | 0.98511048 |
| 48 | MAP3K2 | 0.97610513 |
| 49 | PDGFRA | 0.96553051 |
| 50 | CDK4 | 0.96028762 |
| 51 | MAP3K9 | 0.95636721 |
| 52 | CAMK4 | 0.94878160 |
| 53 | TAOK3 | 0.93549004 |
| 54 | PDGFRB | 0.93235250 |
| 55 | PRKD2 | 0.93081650 |
| 56 | JAK3 | 0.92714713 |
| 57 | TYK2 | 0.92204035 |
| 58 | HCK | 0.91805278 |
| 59 | MAPK11 | 0.91240148 |
| 60 | MAP3K13 | 0.90010384 |
| 61 | DYRK1B | 0.89196471 |
| 62 | TXK | 0.89179835 |
| 63 | TYRO3 | 0.88259108 |
| 64 | FES | 0.87942719 |
| 65 | DMPK | 0.87099778 |
| 66 | PIK3CG | 0.86621638 |
| 67 | GRK6 | 0.86024111 |
| 68 | ITK | 0.85411045 |
| 69 | FGR | 0.83097985 |
| 70 | YES1 | 0.80990444 |
| 71 | CSF1R | 0.80758149 |
| 72 | EPHB1 | 0.80332265 |
| 73 | NTRK3 | 0.80080438 |
| 74 | MAPK7 | 0.78896447 |
| 75 | WNK1 | 0.78894641 |
| 76 | JAK2 | 0.78675850 |
| 77 | TNIK | 0.76233832 |
| 78 | IRAK2 | 0.76054478 |
| 79 | PDK1 | 0.75537728 |
| 80 | SIK3 | 0.74799534 |
| 81 | CDK9 | 0.74466147 |
| 82 | BMX | 0.74225191 |
| 83 | RPS6KB2 | 0.73212004 |
| 84 | ATR | 0.72968502 |
| 85 | RPS6KA4 | 0.72905637 |
| 86 | LYN | 0.72255150 |
| 87 | CHUK | 0.71657323 |
| 88 | MAP3K1 | 0.71281640 |
| 89 | CAMKK1 | 0.71186634 |
| 90 | NTRK2 | 0.69123938 |
| 91 | IRAK1 | 0.67523349 |
| 92 | MARK3 | 0.67292257 |
| 93 | PIM1 | 0.67044428 |
| 94 | CDC7 | 0.66471492 |
| 95 | PRKAA1 | 0.66103253 |
| 96 | TTN | 0.65980076 |
| 97 | MAP3K4 | 0.65721709 |
| 98 | MAP3K6 | 0.65218095 |
| 99 | ERBB2 | 0.64032782 |
| 100 | CAMK1 | 0.63396011 |
| 101 | SMG1 | 0.63378095 |
| 102 | STK11 | 0.61424718 |
| 103 | ZAP70 | 0.61098589 |
| 104 | TEC | 0.59177873 |
| 105 | RET | 0.58672772 |
| 106 | KSR1 | 0.58385988 |
| 107 | SGK1 | 0.57579831 |
| 108 | BTK | 0.57199224 |
| 109 | DYRK1A | 0.56579516 |
| 110 | TGFBR2 | 0.56314101 |
| 111 | TNK2 | 0.55840665 |
| 112 | RPS6KA2 | 0.55707713 |
| 113 | CDK2 | 0.55362989 |
| 114 | RAF1 | 0.54404815 |
| 115 | CHEK1 | 0.53259792 |
| 116 | CAMKK2 | 0.53259692 |
| 117 | STK4 | 0.53165434 |
| 118 | MELK | 0.52924080 |
| 119 | SYK | 0.52836179 |
| 120 | FRK | 0.52256214 |
| 121 | UHMK1 | 0.51480315 |
| 122 | MAPK8 | 0.49476583 |
| 123 | PRKAA2 | 0.49417538 |
| 124 | MAPK14 | 0.49269295 |
| 125 | EPHA3 | 0.49255883 |
| 126 | PDPK1 | 0.48619380 |
| 127 | NEK1 | 0.48485753 |
| 128 | MAPK10 | 0.48183182 |
| 129 | TRPM7 | 0.47993798 |
| 130 | GSK3B | 0.47349023 |
| 131 | ATM | 0.47147212 |
| 132 | FGFR1 | 0.46210424 |
| 133 | RPS6KL1 | 0.45919117 |
| 134 | RPS6KC1 | 0.45919117 |
| 135 | MAP2K4 | 0.45322175 |
| 136 | MAPK12 | 0.45118699 |
| 137 | LCK | 0.44091411 |
| 138 | IKBKE | 0.43063316 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Lysine degradation_Homo sapiens_hsa00310 | 2.48764783 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.86530225 |
| 3 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.76362628 |
| 4 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.74899410 |
| 5 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.64827058 |
| 6 | Leishmaniasis_Homo sapiens_hsa05140 | 1.59192985 |
| 7 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.56490626 |
| 8 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.55518536 |
| 9 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.50886886 |
| 10 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.46544614 |
| 11 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.34191366 |
| 12 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.31321184 |
| 13 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.28521476 |
| 14 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.27912143 |
| 15 | Endometrial cancer_Homo sapiens_hsa05213 | 1.26887255 |
| 16 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.24704992 |
| 17 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.24400121 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.20157580 |
| 19 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.20025420 |
| 20 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.19901311 |
| 21 | Insulin resistance_Homo sapiens_hsa04931 | 1.19492139 |
| 22 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.19075760 |
| 23 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.14714132 |
| 24 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.14523273 |
| 25 | Tuberculosis_Homo sapiens_hsa05152 | 1.11809734 |
| 26 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.11106796 |
| 27 | ABC transporters_Homo sapiens_hsa02010 | 1.08492312 |
| 28 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.08091605 |
| 29 | Glioma_Homo sapiens_hsa05214 | 1.06039011 |
| 30 | Colorectal cancer_Homo sapiens_hsa05210 | 1.04360515 |
| 31 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.04186218 |
| 32 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.01995316 |
| 33 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.01894548 |
| 34 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.01123850 |
| 35 | Long-term potentiation_Homo sapiens_hsa04720 | 1.00473500 |
| 36 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.00095716 |
| 37 | Olfactory transduction_Homo sapiens_hsa04740 | 0.95781571 |
| 38 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.95627902 |
| 39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.95565119 |
| 40 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.95356282 |
| 41 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.95016553 |
| 42 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.93034779 |
| 43 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.92155584 |
| 44 | Hepatitis B_Homo sapiens_hsa05161 | 0.92072488 |
| 45 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.91918786 |
| 46 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.91892131 |
| 47 | Hepatitis C_Homo sapiens_hsa05160 | 0.91322772 |
| 48 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.90648302 |
| 49 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.89688247 |
| 50 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.89383558 |
| 51 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.88759749 |
| 52 | Measles_Homo sapiens_hsa05162 | 0.88213898 |
| 53 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.86988772 |
| 54 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.85418118 |
| 55 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.85040399 |
| 56 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.84858664 |
| 57 | Thyroid cancer_Homo sapiens_hsa05216 | 0.84790813 |
| 58 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.84276262 |
| 59 | Circadian entrainment_Homo sapiens_hsa04713 | 0.83308738 |
| 60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.83053691 |
| 61 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.82284626 |
| 62 | Allograft rejection_Homo sapiens_hsa05330 | 0.81823145 |
| 63 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.81597598 |
| 64 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.80619957 |
| 65 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.80472636 |
| 66 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.79792147 |
| 67 | Prostate cancer_Homo sapiens_hsa05215 | 0.79657946 |
| 68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.78707386 |
| 69 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.78550728 |
| 70 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.78550335 |
| 71 | Platelet activation_Homo sapiens_hsa04611 | 0.78496605 |
| 72 | Circadian rhythm_Homo sapiens_hsa04710 | 0.78029152 |
| 73 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.77756680 |
| 74 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.77544159 |
| 75 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.77353065 |
| 76 | Morphine addiction_Homo sapiens_hsa05032 | 0.76963438 |
| 77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.76395227 |
| 78 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.75885709 |
| 79 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.74216094 |
| 80 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.73755622 |
| 81 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.73399396 |
| 82 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.72408872 |
| 83 | Influenza A_Homo sapiens_hsa05164 | 0.71984189 |
| 84 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.71803168 |
| 85 | Viral myocarditis_Homo sapiens_hsa05416 | 0.70944200 |
| 86 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.70714342 |
| 87 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.70217399 |
| 88 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.70059528 |
| 89 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.69472351 |
| 90 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.68806708 |
| 91 | Adherens junction_Homo sapiens_hsa04520 | 0.68117649 |
| 92 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.67309739 |
| 93 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.66127862 |
| 94 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.63703688 |
| 95 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.63671915 |
| 96 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.63410282 |
| 97 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.63273897 |
| 98 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.63184968 |
| 99 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.63145489 |
| 100 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.62925970 |
| 101 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.62830232 |
| 102 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.62632915 |
| 103 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.62588116 |
| 104 | Bile secretion_Homo sapiens_hsa04976 | 0.61209946 |
| 105 | Insulin secretion_Homo sapiens_hsa04911 | 0.60967156 |
| 106 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.60642195 |
| 107 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.59641118 |
| 108 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.59098469 |
| 109 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.58903847 |
| 110 | Malaria_Homo sapiens_hsa05144 | 0.58771645 |
| 111 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.58417467 |
| 112 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.57572728 |
| 113 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.56962366 |
| 114 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.56861391 |
| 115 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.56623279 |
| 116 | Long-term depression_Homo sapiens_hsa04730 | 0.56571241 |
| 117 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.56486242 |
| 118 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.56205966 |
| 119 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.55930341 |
| 120 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.55289697 |
| 121 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.53056694 |
| 122 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.52889508 |
| 123 | Apoptosis_Homo sapiens_hsa04210 | 0.52760529 |
| 124 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.52151546 |
| 125 | GABAergic synapse_Homo sapiens_hsa04727 | 0.51971820 |
| 126 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.50757651 |
| 127 | Endocytosis_Homo sapiens_hsa04144 | 0.49469045 |
| 128 | Other glycan degradation_Homo sapiens_hsa00511 | 0.48943789 |

