RBM34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.60637118
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.91955394
3ATP synthesis coupled proton transport (GO:0015986)4.91955394
4chaperone-mediated protein transport (GO:0072321)4.75571600
5maturation of SSU-rRNA (GO:0030490)4.62250273
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49465247
7cullin deneddylation (GO:0010388)4.11645905
8proteasome assembly (GO:0043248)4.11504521
9ribosomal small subunit biogenesis (GO:0042274)4.10047326
10respiratory electron transport chain (GO:0022904)4.01994306
11ribosomal large subunit biogenesis (GO:0042273)4.01108162
12protein neddylation (GO:0045116)4.00924944
13DNA double-strand break processing (GO:0000729)3.96538872
14electron transport chain (GO:0022900)3.95606057
15mitochondrial respiratory chain complex assembly (GO:0033108)3.94427288
16protein complex biogenesis (GO:0070271)3.93350530
17ribosomal small subunit assembly (GO:0000028)3.89324621
18CENP-A containing nucleosome assembly (GO:0034080)3.88750767
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.88224963
20chromatin remodeling at centromere (GO:0031055)3.86850066
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.86417817
22DNA replication initiation (GO:0006270)3.82557621
23NADH dehydrogenase complex assembly (GO:0010257)3.81771079
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81771079
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.81771079
26protein deneddylation (GO:0000338)3.80044484
27telomere maintenance via semi-conservative replication (GO:0032201)3.73675954
28kinetochore organization (GO:0051383)3.71614204
29ribonucleoprotein complex biogenesis (GO:0022613)3.68611633
30DNA strand elongation involved in DNA replication (GO:0006271)3.68021312
31pseudouridine synthesis (GO:0001522)3.62589009
32kinetochore assembly (GO:0051382)3.62291905
33spliceosomal complex assembly (GO:0000245)3.59780853
34water-soluble vitamin biosynthetic process (GO:0042364)3.57357009
35DNA strand elongation (GO:0022616)3.56389245
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.55457366
37ribosome assembly (GO:0042255)3.55287096
38rRNA processing (GO:0006364)3.54958949
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.50861445
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.50623989
41DNA deamination (GO:0045006)3.48515124
42establishment of integrated proviral latency (GO:0075713)3.47994255
43DNA replication checkpoint (GO:0000076)3.47422048
44termination of RNA polymerase III transcription (GO:0006386)3.44629267
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.44629267
46ribosome biogenesis (GO:0042254)3.44522501
47rRNA metabolic process (GO:0016072)3.42425775
48protein targeting to mitochondrion (GO:0006626)3.39447848
49translational termination (GO:0006415)3.38128216
50termination of RNA polymerase I transcription (GO:0006363)3.35750854
51regulation of mitochondrial translation (GO:0070129)3.35337723
52regulation of helicase activity (GO:0051095)3.35131991
53telomere maintenance via telomere lengthening (GO:0010833)3.33383608
54viral transcription (GO:0019083)3.32864720
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32566983
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32566983
57organelle disassembly (GO:1903008)3.30279600
58purine nucleobase biosynthetic process (GO:0009113)3.29982510
59spliceosomal snRNP assembly (GO:0000387)3.27472772
60DNA replication-independent nucleosome organization (GO:0034724)3.26872476
61DNA replication-independent nucleosome assembly (GO:0006336)3.26872476
62establishment of protein localization to mitochondrion (GO:0072655)3.25745806
63pyrimidine nucleobase catabolic process (GO:0006208)3.25071858
64telomere maintenance via recombination (GO:0000722)3.24297748
65tRNA processing (GO:0008033)3.23725526
66mitotic metaphase plate congression (GO:0007080)3.22647842
67nucleobase biosynthetic process (GO:0046112)3.22150057
68DNA unwinding involved in DNA replication (GO:0006268)3.21364851
69DNA catabolic process, exonucleolytic (GO:0000738)3.20540563
70mitotic recombination (GO:0006312)3.16478464
71protein-cofactor linkage (GO:0018065)3.15447756
72protein localization to mitochondrion (GO:0070585)3.12360383
73establishment of viral latency (GO:0019043)3.11925362
74transcription from RNA polymerase I promoter (GO:0006360)3.11154028
75transcription-coupled nucleotide-excision repair (GO:0006283)3.10635671
76maturation of 5.8S rRNA (GO:0000460)3.09754726
77protein K6-linked ubiquitination (GO:0085020)3.08650372
78sequestering of actin monomers (GO:0042989)3.07865047
79ribonucleoprotein complex disassembly (GO:0032988)3.06213614
80histone exchange (GO:0043486)3.06063728
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03790748
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03597556
83respiratory chain complex IV assembly (GO:0008535)3.03091946
84regulation of cellular amino acid metabolic process (GO:0006521)3.01887947
857-methylguanosine mRNA capping (GO:0006370)3.01870105
86tRNA methylation (GO:0030488)3.00274744
877-methylguanosine RNA capping (GO:0009452)2.98662492
88RNA capping (GO:0036260)2.98662492
89protein localization to endoplasmic reticulum (GO:0070972)2.97540307
90translational initiation (GO:0006413)2.97320888
91telomere maintenance via telomerase (GO:0007004)2.96621451
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96450430
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.94212164
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92456690
95cellular component biogenesis (GO:0044085)2.91069165
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90627592
97DNA damage response, detection of DNA damage (GO:0042769)2.89697507
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.89693975
99DNA ligation (GO:0006266)2.89240293
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88992594
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88992594
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88992594
103transcription initiation from RNA polymerase I promoter (GO:0006361)2.88246930
104cytochrome complex assembly (GO:0017004)2.87981708
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87971311
106tRNA metabolic process (GO:0006399)2.87926908
107translational elongation (GO:0006414)2.87099332
108formation of translation preinitiation complex (GO:0001731)2.84645059
109somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.84348294
110isotype switching (GO:0045190)2.84348294
111somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.84348294
112GTP biosynthetic process (GO:0006183)2.83896426
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83673962
114intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83673962
115replication fork processing (GO:0031297)2.82591408
116intracellular protein transmembrane import (GO:0044743)2.82389199
117ncRNA processing (GO:0034470)2.82094868
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80769644
119UTP biosynthetic process (GO:0006228)2.80648687
120rRNA modification (GO:0000154)2.80168642
121DNA replication-dependent nucleosome organization (GO:0034723)2.80113876
122DNA replication-dependent nucleosome assembly (GO:0006335)2.80113876
123positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79996784
124viral mRNA export from host cell nucleus (GO:0046784)2.79952168
125positive regulation of prostaglandin secretion (GO:0032308)2.79899202
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79767657
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79652140
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78443628
129regulation of mitotic spindle checkpoint (GO:1903504)2.78443628
130cotranslational protein targeting to membrane (GO:0006613)2.77971043
131guanosine-containing compound biosynthetic process (GO:1901070)2.77827440
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77747886
133RNA-dependent DNA replication (GO:0006278)2.77659894
134DNA-templated transcription, termination (GO:0006353)2.77420159
135meiotic chromosome segregation (GO:0045132)2.76509349
136intra-S DNA damage checkpoint (GO:0031573)2.75815824
137IMP biosynthetic process (GO:0006188)2.75186920
138nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74817094
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.74464673
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74464673
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74291417
142protein targeting to ER (GO:0045047)2.73633252
143microtubule depolymerization (GO:0007019)2.73530735
144metaphase plate congression (GO:0051310)2.72850200
145pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.72352908
146ncRNA metabolic process (GO:0034660)2.71673557
147negative regulation of ligase activity (GO:0051352)2.71397496
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71397496
149translation (GO:0006412)2.70913714
150cellular protein complex disassembly (GO:0043624)2.70697322
151histone mRNA metabolic process (GO:0008334)2.70169982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19313355
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45366711
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86935417
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73914394
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.40993857
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37642965
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14653774
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08920153
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00117063
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92099785
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.89849283
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79810402
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79795005
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73384326
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69670468
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69150249
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51817773
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.46892639
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41171124
20* VDR_23849224_ChIP-Seq_CD4+_Human2.38013537
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33882786
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33618666
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32848863
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31152743
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22028068
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21352439
27FOXP3_21729870_ChIP-Seq_TREG_Human2.13289512
28* ELK1_19687146_ChIP-ChIP_HELA_Human2.10303352
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.07445359
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06929745
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.03846429
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99956577
33* XRN2_22483619_ChIP-Seq_HELA_Human1.96761637
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96584802
35TTF2_22483619_ChIP-Seq_HELA_Human1.94937824
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89508979
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85100721
38DCP1A_22483619_ChIP-Seq_HELA_Human1.82536472
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81343645
40AR_21909140_ChIP-Seq_LNCAP_Human1.79582835
41ZNF274_21170338_ChIP-Seq_K562_Hela1.78356462
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73770685
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72973225
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70247425
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.64409249
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.60866770
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57555910
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57555910
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57555910
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56717459
51* GABP_19822575_ChIP-Seq_HepG2_Human1.55871920
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55829682
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.55795651
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53554457
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51043807
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50852128
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49734452
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47892854
59IRF1_19129219_ChIP-ChIP_H3396_Human1.46998924
60* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44722187
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44205421
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.43172353
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42909595
64VDR_22108803_ChIP-Seq_LS180_Human1.41866137
65MYC_18940864_ChIP-ChIP_HL60_Human1.41414526
66IGF1R_20145208_ChIP-Seq_DFB_Human1.40610124
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37643895
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34941762
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30193332
70* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28564183
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26832488
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25540982
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24652699
74FUS_26573619_Chip-Seq_HEK293_Human1.23365222
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.21757521
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20432755
77* EWS_26573619_Chip-Seq_HEK293_Human1.18239573
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.17666400
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17283035
80TP53_22573176_ChIP-Seq_HFKS_Human1.15773027
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14950287
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14610220
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11054264
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10802678
85* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10236048
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07312947
87CIITA_25753668_ChIP-Seq_RAJI_Human1.05563444
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05209315
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04803053
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02485824
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00692194
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98113688
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97606870
94KDM5A_27292631_Chip-Seq_BREAST_Human0.96965704
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95486439
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95125230
97P300_19829295_ChIP-Seq_ESCs_Human0.93714590
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93019744
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92603053
100HTT_18923047_ChIP-ChIP_STHdh_Human0.91576399
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90584717
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90010092
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89807392
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88809772
105TAF15_26573619_Chip-Seq_HEK293_Human0.88652194
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.87653528
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87107403
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85592074
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85182553
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84643689
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82404648
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81300944
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.80984407
114CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80892464
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.80676951
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80184692
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79888343
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77905173
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.76966126
120TFEB_21752829_ChIP-Seq_HELA_Human0.76708016
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.75941425
122FOXA1_25329375_ChIP-Seq_VCAP_Human0.74467687
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74467687
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.74243083
125* SPI1_23547873_ChIP-Seq_NB4_Human0.72416607
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70062628
127* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67761030
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65983942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.07005551
2MP0010094_abnormal_chromosome_stability3.76867921
3MP0003111_abnormal_nucleus_morphology3.69524147
4MP0008057_abnormal_DNA_replication3.66062877
5MP0004957_abnormal_blastocyst_morpholog3.58732529
6MP0008058_abnormal_DNA_repair3.46032987
7MP0003806_abnormal_nucleotide_metabolis3.36876626
8MP0003136_yellow_coat_color3.36859871
9MP0003077_abnormal_cell_cycle3.13414354
10MP0003122_maternal_imprinting3.09920761
11MP0006292_abnormal_olfactory_placode3.02145825
12MP0008932_abnormal_embryonic_tissue2.79593024
13MP0005645_abnormal_hypothalamus_physiol2.70886871
14MP0008007_abnormal_cellular_replicative2.36995051
15MP0001188_hyperpigmentation2.29587059
16MP0003718_maternal_effect2.24202834
17MP0000566_synostosis2.14428820
18MP0002102_abnormal_ear_morphology2.11238801
19MP0003123_paternal_imprinting2.09895936
20MP0001984_abnormal_olfaction2.03893200
21MP0003786_premature_aging2.03693922
22MP0009379_abnormal_foot_pigmentation1.92609188
23MP0008877_abnormal_DNA_methylation1.91082996
24MP0002837_dystrophic_cardiac_calcinosis1.84287784
25MP0005409_darkened_coat_color1.78459048
26MP0004133_heterotaxia1.76447865
27MP0006072_abnormal_retinal_apoptosis1.74917148
28MP0005084_abnormal_gallbladder_morpholo1.60363801
29MP0002876_abnormal_thyroid_physiology1.59476932
30MP0000015_abnormal_ear_pigmentation1.58518198
31MP0003941_abnormal_skin_development1.56916100
32MP0006036_abnormal_mitochondrial_physio1.55960005
33MP0002822_catalepsy1.54384915
34MP0003011_delayed_dark_adaptation1.52780977
35MP0001730_embryonic_growth_arrest1.52068955
36MP0002396_abnormal_hematopoietic_system1.51226582
37MP0000350_abnormal_cell_proliferation1.50459053
38MP0003787_abnormal_imprinting1.50447134
39MP0001986_abnormal_taste_sensitivity1.45006960
40MP0003121_genomic_imprinting1.43435328
41MP0008260_abnormal_autophagy1.42037732
42MP0000490_abnormal_crypts_of1.41965439
43MP0001293_anophthalmia1.41713567
44MP0005075_abnormal_melanosome_morpholog1.41417576
45MP0004147_increased_porphyrin_level1.34470144
46MP0002938_white_spotting1.32594970
47MP0002095_abnormal_skin_pigmentation1.25949265
48MP0003315_abnormal_perineum_morphology1.25883317
49MP0003937_abnormal_limbs/digits/tail_de1.24509512
50MP0006035_abnormal_mitochondrial_morpho1.23546794
51MP0009046_muscle_twitch1.23322984
52MP0008872_abnormal_physiological_respon1.23151056
53MP0004381_abnormal_hair_follicle1.22040183
54MP0003938_abnormal_ear_development1.20887450
55MP0002210_abnormal_sex_determination1.19568252
56MP0005380_embryogenesis_phenotype1.17051288
57MP0001672_abnormal_embryogenesis/_devel1.17051288
58MP0001529_abnormal_vocalization1.16922160
59MP0002751_abnormal_autonomic_nervous1.16695338
60MP0003890_abnormal_embryonic-extraembry1.16069856
61MP0002085_abnormal_embryonic_tissue1.15284190
62MP0005253_abnormal_eye_physiology1.14608679
63MP0009697_abnormal_copulation1.14547412
64MP0000313_abnormal_cell_death1.13402342
65MP0002254_reproductive_system_inflammat1.12468305
66MP0000778_abnormal_nervous_system1.11800520
67MP0001697_abnormal_embryo_size1.09389015
68MP0005174_abnormal_tail_pigmentation1.08307900
69MP0001286_abnormal_eye_development1.06308306
70MP0005266_abnormal_metabolism1.05494659
71MP0003567_abnormal_fetal_cardiomyocyte1.04070901
72MP0000049_abnormal_middle_ear1.03348473
73MP0003880_abnormal_central_pattern1.03241866
74MP0002736_abnormal_nociception_after1.01004355
75MP0009333_abnormal_splenocyte_physiolog1.00364265
76MP0002557_abnormal_social/conspecific_i0.99884113
77MP0001145_abnormal_male_reproductive0.99370457
78MP0002163_abnormal_gland_morphology0.99179218
79MP0002160_abnormal_reproductive_system0.99111482
80MP0002084_abnormal_developmental_patter0.97830056
81MP0005646_abnormal_pituitary_gland0.96259996
82MP0002132_abnormal_respiratory_system0.93852929
83MP0003984_embryonic_growth_retardation0.93770091
84MP0002080_prenatal_lethality0.93256447
85MP0003763_abnormal_thymus_physiology0.92867536
86MP0002088_abnormal_embryonic_growth/wei0.91229548
87MP0005389_reproductive_system_phenotype0.90378706
88MP0002277_abnormal_respiratory_mucosa0.90274498
89MP0004924_abnormal_behavior0.89389544
90MP0005386_behavior/neurological_phenoty0.89389544
91MP0003698_abnormal_male_reproductive0.89223149
92MP0002733_abnormal_thermal_nociception0.89016658
93MP0008770_decreased_survivor_rate0.88601964
94MP0001968_abnormal_touch/_nociception0.88390147
95MP0005171_absent_coat_pigmentation0.87517750
96MP0001919_abnormal_reproductive_system0.85777877
97MP0000703_abnormal_thymus_morphology0.85506417
98MP0000631_abnormal_neuroendocrine_gland0.85502900
99MP0009745_abnormal_behavioral_response0.85398893
100MP0002234_abnormal_pharynx_morphology0.84947586
101MP0010030_abnormal_orbit_morphology0.83914177
102MP0000653_abnormal_sex_gland0.83894662
103MP0005408_hypopigmentation0.83624374
104MP0000372_irregular_coat_pigmentation0.82816607
105MP0003755_abnormal_palate_morphology0.82571671
106MP0008789_abnormal_olfactory_epithelium0.80947140
107MP0001502_abnormal_circadian_rhythm0.80923241
108MP0000432_abnormal_head_morphology0.80848125
109MP0005551_abnormal_eye_electrophysiolog0.80140047
110MP0000358_abnormal_cell_content/0.79706992
111MP0001929_abnormal_gametogenesis0.78826668
112MP0005410_abnormal_fertilization0.78428790
113MP0002638_abnormal_pupillary_reflex0.78291542
114MP0005499_abnormal_olfactory_system0.77358323
115MP0005394_taste/olfaction_phenotype0.77358323
116MP0002177_abnormal_outer_ear0.76747712
117MP0001764_abnormal_homeostasis0.76661153
118MP0003186_abnormal_redox_activity0.76649902
119MP0002233_abnormal_nose_morphology0.76561728
120MP0002019_abnormal_tumor_incidence0.76423713
121MP0008995_early_reproductive_senescence0.75878432
122MP0001905_abnormal_dopamine_level0.75757652
123MP0004811_abnormal_neuron_physiology0.75609367
124MP0003861_abnormal_nervous_system0.74892737
125MP0005671_abnormal_response_to0.73687974
126MP0001970_abnormal_pain_threshold0.73308549
127MP0002067_abnormal_sensory_capabilities0.72337645
128MP0001727_abnormal_embryo_implantation0.71882789
129MP0002086_abnormal_extraembryonic_tissu0.71276762
130MP0001119_abnormal_female_reproductive0.71244571
131MP0002272_abnormal_nervous_system0.70771645
132MP0004197_abnormal_fetal_growth/weight/0.69226641
133MP0001186_pigmentation_phenotype0.68905371
134MP0003137_abnormal_impulse_conducting0.68591994
135MP0006276_abnormal_autonomic_nervous0.68249424
136MP0002722_abnormal_immune_system0.67940918
137MP0003936_abnormal_reproductive_system0.66777353
138MP0004142_abnormal_muscle_tone0.66236548
139MP0005195_abnormal_posterior_eye0.66012601
140MP0004808_abnormal_hematopoietic_stem0.65820110
141MP0002752_abnormal_somatic_nervous0.65713869
142MP0010352_gastrointestinal_tract_polyps0.65591425
143MP0002398_abnormal_bone_marrow0.65560188
144MP0005379_endocrine/exocrine_gland_phen0.65414407
145MP0008875_abnormal_xenobiotic_pharmacok0.65365115
146MP0000689_abnormal_spleen_morphology0.64652779
147MP0001881_abnormal_mammary_gland0.63925879
148MP0001440_abnormal_grooming_behavior0.63427288
149MP0005423_abnormal_somatic_nervous0.63284930
150MP0002114_abnormal_axial_skeleton0.61352359

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.90666815
2Abnormal mitochondria in muscle tissue (HP:0008316)4.39996465
3Acute encephalopathy (HP:0006846)4.36695493
4Mitochondrial inheritance (HP:0001427)4.32188147
5Birth length less than 3rd percentile (HP:0003561)4.25959398
6Lipid accumulation in hepatocytes (HP:0006561)4.21988516
7Progressive macrocephaly (HP:0004481)4.15385875
8Increased CSF lactate (HP:0002490)4.02710136
9Chromsome breakage (HP:0040012)4.00997840
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85395372
11Reticulocytopenia (HP:0001896)3.80908305
12Renal Fanconi syndrome (HP:0001994)3.72074400
13Supernumerary spleens (HP:0009799)3.45610860
14Hypoplasia of the pons (HP:0012110)3.36842334
15Hepatocellular necrosis (HP:0001404)3.34809400
16Methylmalonic acidemia (HP:0002912)3.31576941
17Cerebral edema (HP:0002181)3.27925013
18Abnormality of the pons (HP:0007361)3.27312074
19Breast hypoplasia (HP:0003187)3.21692390
20Hepatic necrosis (HP:0002605)3.18906691
21Absent radius (HP:0003974)3.17243665
22Abnormality of chromosome stability (HP:0003220)3.06214284
23Absent forearm bone (HP:0003953)3.02624330
24Aplasia involving forearm bones (HP:0009822)3.02624330
25Increased intramyocellular lipid droplets (HP:0012240)2.99596062
26Duplicated collecting system (HP:0000081)2.96830648
27Abnormality of the preputium (HP:0100587)2.95778275
28Meckel diverticulum (HP:0002245)2.91703572
29Exertional dyspnea (HP:0002875)2.89997129
30Abnormality of the labia minora (HP:0012880)2.87417849
31Abnormality of the ileum (HP:0001549)2.84431351
32Methylmalonic aciduria (HP:0012120)2.81072672
33Oral leukoplakia (HP:0002745)2.77003597
34Increased serum lactate (HP:0002151)2.76193998
35Asplenia (HP:0001746)2.75898738
36Lactic acidosis (HP:0003128)2.72204753
37Rough bone trabeculation (HP:0100670)2.68528568
38Cerebral hypomyelination (HP:0006808)2.68087912
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.66358742
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66186423
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66186423
42Aplastic anemia (HP:0001915)2.58640523
43Abnormality of the renal collecting system (HP:0004742)2.57163299
44Bone marrow hypocellularity (HP:0005528)2.56245629
45Type II lissencephaly (HP:0007260)2.54117940
46Septo-optic dysplasia (HP:0100842)2.51402740
47Macrocytic anemia (HP:0001972)2.50536887
48Triphalangeal thumb (HP:0001199)2.49651932
49Patellar aplasia (HP:0006443)2.49012688
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.48497874
51Abnormality of midbrain morphology (HP:0002418)2.47491950
52Molar tooth sign on MRI (HP:0002419)2.47491950
53Respiratory failure (HP:0002878)2.46116591
54Leukodystrophy (HP:0002415)2.45788058
55Abnormality of cells of the erythroid lineage (HP:0012130)2.45736077
56Optic disc pallor (HP:0000543)2.43497598
57Median cleft lip (HP:0000161)2.42452475
58Abnormality of DNA repair (HP:0003254)2.42074298
59Respiratory difficulties (HP:0002880)2.41031859
60Duplication of thumb phalanx (HP:0009942)2.40811622
61Exercise intolerance (HP:0003546)2.40556259
62Abnormality of the columella (HP:0009929)2.40247244
63Premature graying of hair (HP:0002216)2.39332873
64Poor head control (HP:0002421)2.38229760
65Pallor (HP:0000980)2.37908659
66Increased muscle lipid content (HP:0009058)2.37515617
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34923808
68Microvesicular hepatic steatosis (HP:0001414)2.34032423
69Intestinal atresia (HP:0011100)2.30083126
70Abnormal number of erythroid precursors (HP:0012131)2.29512255
71Colon cancer (HP:0003003)2.29355402
72Cerebellar dysplasia (HP:0007033)2.28876335
73Abnormal lung lobation (HP:0002101)2.27929433
74Aplasia/Hypoplasia of the patella (HP:0006498)2.26152552
75Absent thumb (HP:0009777)2.25042203
76Abnormality of renal resorption (HP:0011038)2.23506729
77Small intestinal stenosis (HP:0012848)2.19100939
78Duodenal stenosis (HP:0100867)2.19100939
79Abnormality of the septum pellucidum (HP:0007375)2.18237006
80Carpal bone hypoplasia (HP:0001498)2.14741587
81Renal cortical cysts (HP:0000803)2.11863960
82Absent septum pellucidum (HP:0001331)2.11456309
83Abnormal trabecular bone morphology (HP:0100671)2.11083681
84Myelodysplasia (HP:0002863)2.10430664
85Ectopic kidney (HP:0000086)2.09324385
86Abnormality of the anterior horn cell (HP:0006802)2.08586960
87Degeneration of anterior horn cells (HP:0002398)2.08586960
88Impulsivity (HP:0100710)2.07907567
89Selective tooth agenesis (HP:0001592)2.06883943
90Pancreatic fibrosis (HP:0100732)2.06845966
9111 pairs of ribs (HP:0000878)2.05225304
92Horseshoe kidney (HP:0000085)2.04807187
93Abnormality of methionine metabolism (HP:0010901)2.04126794
94Lethargy (HP:0001254)2.02873383
95Lissencephaly (HP:0001339)2.02176765
96Stenosis of the external auditory canal (HP:0000402)2.02140580
97Abnormal number of incisors (HP:0011064)2.01307686
98Abnormality of urine glucose concentration (HP:0011016)1.99702831
99Glycosuria (HP:0003076)1.99702831
100Nephroblastoma (Wilms tumor) (HP:0002667)1.99589171
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98925676
102Hyperglycinemia (HP:0002154)1.97989035
103Prolonged neonatal jaundice (HP:0006579)1.97615553
104Volvulus (HP:0002580)1.96543525
105Parakeratosis (HP:0001036)1.95219663
106Agnosia (HP:0010524)1.94950551
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94349810
108Abnormality of alanine metabolism (HP:0010916)1.94349810
109Hyperalaninemia (HP:0003348)1.94349810
110High anterior hairline (HP:0009890)1.94072234
111Abnormality of the duodenum (HP:0002246)1.93542953
112Oligodactyly (hands) (HP:0001180)1.93426842
113Cellular immunodeficiency (HP:0005374)1.91955159
114X-linked dominant inheritance (HP:0001423)1.90989810
115Pancytopenia (HP:0001876)1.90417713
116Embryonal renal neoplasm (HP:0011794)1.90296801
117Tracheoesophageal fistula (HP:0002575)1.89538031
1183-Methylglutaconic aciduria (HP:0003535)1.88846806
119Abnormal glycosylation (HP:0012345)1.86974585
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86974585
121Abnormal protein N-linked glycosylation (HP:0012347)1.86974585
122Abnormal protein glycosylation (HP:0012346)1.86974585
123Medulloblastoma (HP:0002885)1.85801082
124Hypoplasia of the radius (HP:0002984)1.84730986
125Neoplasm of the pancreas (HP:0002894)1.83159589
126Abnormality of serum amino acid levels (HP:0003112)1.82757811
127Abnormality of the incisor (HP:0000676)1.82478144
128Increased hepatocellular lipid droplets (HP:0006565)1.81316281
129Abdominal situs inversus (HP:0003363)1.80991903
130Abnormality of abdominal situs (HP:0011620)1.80991903
131Clubbing of toes (HP:0100760)1.80874843
132Pachygyria (HP:0001302)1.80484586
133Medial flaring of the eyebrow (HP:0010747)1.80102035
134Limb dystonia (HP:0002451)1.79059344
135Sloping forehead (HP:0000340)1.78813685
136Aplasia/hypoplasia of the uterus (HP:0008684)1.78576143
137Poor suck (HP:0002033)1.78380154
138Abnormal hair whorl (HP:0010721)1.77972089
139Rectovaginal fistula (HP:0000143)1.77251269
140Rectal fistula (HP:0100590)1.77251269
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.77061193
142Type I transferrin isoform profile (HP:0003642)1.76648124
143Nephronophthisis (HP:0000090)1.76004420
144Lymphoma (HP:0002665)1.75908088
145CNS demyelination (HP:0007305)1.75812693
146Large eyes (HP:0001090)1.75442290
147Hyperphosphaturia (HP:0003109)1.75407681
148Abnormality of vitamin B metabolism (HP:0004340)1.75133303
149Congenital, generalized hypertrichosis (HP:0004540)1.74603705
150Pendular nystagmus (HP:0012043)1.74526234
151Calf muscle hypertrophy (HP:0008981)1.74261395
152Gastrointestinal atresia (HP:0002589)1.73433577
153Squamous cell carcinoma (HP:0002860)1.73361412
154Esophageal atresia (HP:0002032)1.73011892
155Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71209302
156True hermaphroditism (HP:0010459)1.71052883
157Facial hemangioma (HP:0000329)1.70572467
158Partial duplication of thumb phalanx (HP:0009944)1.70538616
159Pancreatic cysts (HP:0001737)1.68201058
160Preaxial hand polydactyly (HP:0001177)1.67562902
161Type 2 muscle fiber atrophy (HP:0003554)1.66851988
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66263982
163Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64677156
164Shoulder girdle muscle weakness (HP:0003547)1.64548278
165Cleft eyelid (HP:0000625)1.64037584
166Ependymoma (HP:0002888)1.63583580
167Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62546080
168IgG deficiency (HP:0004315)1.61612568
169Aplasia/Hypoplasia of the earlobes (HP:0009906)1.61534726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.87299338
2SRPK13.33829738
3MAP4K23.32799934
4WEE13.23063865
5STK162.96433559
6CDC72.81408347
7VRK22.61775845
8PNCK2.61439336
9EIF2AK12.58739212
10MKNK22.57999278
11MKNK12.54699644
12CASK2.31735824
13NME22.31013611
14PLK42.24239948
15VRK12.02189360
16TTK1.90705760
17TLK11.90206214
18TSSK61.87135994
19PLK31.82595215
20PBK1.80055177
21EPHA21.72562651
22ZAK1.64342745
23NEK11.61662607
24EIF2AK31.60268971
25PLK11.59301453
26BCKDK1.53050281
27MARK11.51822715
28FRK1.51746257
29DYRK31.47764756
30ACVR1B1.46985028
31TESK21.46834698
32CDK71.45665875
33PASK1.44906706
34MAP3K41.38325288
35WNK31.36014469
36MAP2K71.35754586
37TRIM281.32964656
38BLK1.32632019
39AURKB1.32356055
40TNIK1.32318547
41EIF2AK21.30936910
42AKT31.28393053
43ATR1.27994468
44CHEK21.24726684
45YES11.13741888
46ADRBK21.13185863
47ERBB31.13006864
48TAF11.12579380
49NEK21.10876638
50AURKA1.07774332
51RPS6KB21.03232781
52DYRK20.98198854
53CHEK10.96414201
54TXK0.92456910
55ALK0.92351715
56IRAK40.90201475
57CLK10.88434420
58BCR0.85033378
59ATM0.83077437
60CSNK2A20.82956155
61MST40.82864286
62CSNK1G30.82532428
63IRAK30.79185413
64MAPK130.78152010
65RPS6KA50.77884261
66NLK0.75445997
67NME10.74699564
68CSNK2A10.72998962
69PHKG10.71461710
70PHKG20.71461710
71FES0.71326968
72BMPR1B0.68017676
73CSNK1A1L0.67628258
74BRSK20.67205297
75KDR0.66536716
76CDK20.66119958
77TEC0.65017929
78STK38L0.64128093
79BRD40.63490029
80RPS6KA40.62860191
81CDK120.62593231
82STK390.61808713
83CCNB10.60816935
84CSNK1E0.60150306
85STK40.60021424
86NUAK10.58981295
87CSNK1G10.57690517
88PAK30.56838599
89PRKCI0.56240903
90CDK10.56184789
91PIM10.55643687
92PRKCE0.55626868
93NEK60.51182647
94PRKCG0.50609797
95PKN10.50484856
96STK30.49374074
97SCYL20.48654014
98CDK40.48499800
99GRK10.48435705
100PINK10.47814830
101CDK190.46287225
102PIM20.45578963
103DYRK1A0.45290288
104WNK40.45032476
105MAP2K60.44854901
106PLK20.44020897
107IRAK20.42416557
108CSNK1A10.41889901
109TAOK30.41824569
110IRAK10.41303943
111TGFBR10.41225333
112MINK10.40479165
113UHMK10.40156146
114CSNK1D0.38232046
115PAK40.38061017
116CSNK1G20.37126533
117CDK80.36545197
118GRK50.36532837
119CDK90.36499083
120PDK20.36493752
121MELK0.36444527
122PRPF4B0.36416424
123LATS20.34090280
124INSRR0.33282425
125TNK20.32957178
126LIMK10.32548193
127TIE10.31946896
128CDK30.29863756
129LYN0.29812290
130PRKDC0.29796472
131OXSR10.29653112
132PAK10.26706907
133MAP3K120.26230860
134MARK30.25355832
135IKBKB0.25309127

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.87362286
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85148873
3Mismatch repair_Homo sapiens_hsa034303.79126949
4Ribosome_Homo sapiens_hsa030103.72213659
5RNA polymerase_Homo sapiens_hsa030203.57070473
6Proteasome_Homo sapiens_hsa030503.51457215
7Homologous recombination_Homo sapiens_hsa034403.48863748
8Spliceosome_Homo sapiens_hsa030403.15633635
9Nucleotide excision repair_Homo sapiens_hsa034202.71848370
10Fanconi anemia pathway_Homo sapiens_hsa034602.65737057
11RNA transport_Homo sapiens_hsa030132.63167081
12Base excision repair_Homo sapiens_hsa034102.56262842
13Non-homologous end-joining_Homo sapiens_hsa034502.44101123
14Pyrimidine metabolism_Homo sapiens_hsa002402.40011080
15Basal transcription factors_Homo sapiens_hsa030222.15491177
16Cell cycle_Homo sapiens_hsa041102.09058385
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97144999
18One carbon pool by folate_Homo sapiens_hsa006701.93826869
19RNA degradation_Homo sapiens_hsa030181.93571594
20Cardiac muscle contraction_Homo sapiens_hsa042601.69589832
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60828091
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54502732
23mRNA surveillance pathway_Homo sapiens_hsa030151.54386060
24Purine metabolism_Homo sapiens_hsa002301.51299191
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48961860
26Selenocompound metabolism_Homo sapiens_hsa004501.40516625
27p53 signaling pathway_Homo sapiens_hsa041151.32413160
28Propanoate metabolism_Homo sapiens_hsa006401.30011487
29Protein export_Homo sapiens_hsa030601.25310789
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23702859
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19367759
32Collecting duct acid secretion_Homo sapiens_hsa049661.17402127
33Epstein-Barr virus infection_Homo sapiens_hsa051691.13017329
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05152184
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02638165
36Huntingtons disease_Homo sapiens_hsa050160.93252510
37Systemic lupus erythematosus_Homo sapiens_hsa053220.88354570
38Oxidative phosphorylation_Homo sapiens_hsa001900.84825703
39Peroxisome_Homo sapiens_hsa041460.83881717
40Sphingolipid metabolism_Homo sapiens_hsa006000.83250895
41Parkinsons disease_Homo sapiens_hsa050120.83134210
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81430478
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78397716
44Pyruvate metabolism_Homo sapiens_hsa006200.77353400
45Allograft rejection_Homo sapiens_hsa053300.77224511
46Herpes simplex infection_Homo sapiens_hsa051680.75675661
47Vitamin B6 metabolism_Homo sapiens_hsa007500.75621876
48Tryptophan metabolism_Homo sapiens_hsa003800.74476324
49Butanoate metabolism_Homo sapiens_hsa006500.73668902
50Primary immunodeficiency_Homo sapiens_hsa053400.72429144
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71593209
52Folate biosynthesis_Homo sapiens_hsa007900.70433472
53Autoimmune thyroid disease_Homo sapiens_hsa053200.68899988
54Asthma_Homo sapiens_hsa053100.68119010
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67632900
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67231297
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66102292
58Oocyte meiosis_Homo sapiens_hsa041140.65277720
59Sulfur metabolism_Homo sapiens_hsa009200.63451506
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.63214305
61Arachidonic acid metabolism_Homo sapiens_hsa005900.63151463
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.62371672
63Viral carcinogenesis_Homo sapiens_hsa052030.62144259
64Hematopoietic cell lineage_Homo sapiens_hsa046400.59555999
65Ether lipid metabolism_Homo sapiens_hsa005650.59301351
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57497129
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57281650
68Fatty acid elongation_Homo sapiens_hsa000620.57214384
69Nitrogen metabolism_Homo sapiens_hsa009100.56409592
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.55164577
71Graft-versus-host disease_Homo sapiens_hsa053320.53372691
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51452868
73Antigen processing and presentation_Homo sapiens_hsa046120.49303954
74Steroid biosynthesis_Homo sapiens_hsa001000.49074310
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47947085
76Glutathione metabolism_Homo sapiens_hsa004800.47459552
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46827093
78Sulfur relay system_Homo sapiens_hsa041220.45422508
79TGF-beta signaling pathway_Homo sapiens_hsa043500.45095376
80Phototransduction_Homo sapiens_hsa047440.43643713
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43278445
82MicroRNAs in cancer_Homo sapiens_hsa052060.42384291
83HTLV-I infection_Homo sapiens_hsa051660.42100836
84Olfactory transduction_Homo sapiens_hsa047400.41983934
85Alcoholism_Homo sapiens_hsa050340.41979901
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39650154
87Measles_Homo sapiens_hsa051620.39479077
88Synaptic vesicle cycle_Homo sapiens_hsa047210.39248385
89Basal cell carcinoma_Homo sapiens_hsa052170.38971804
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36814405
91Nicotine addiction_Homo sapiens_hsa050330.36151987
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35573213
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35459472
94Carbon metabolism_Homo sapiens_hsa012000.35376977
95Shigellosis_Homo sapiens_hsa051310.34554693
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.34329975
97Alzheimers disease_Homo sapiens_hsa050100.34153819
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33838736
99Type I diabetes mellitus_Homo sapiens_hsa049400.33281202
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33191544
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32432851
102Notch signaling pathway_Homo sapiens_hsa043300.32322669
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32113436
104Pathways in cancer_Homo sapiens_hsa052000.31664587
105Regulation of autophagy_Homo sapiens_hsa041400.31152909
106Wnt signaling pathway_Homo sapiens_hsa043100.30938095
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30672970
108N-Glycan biosynthesis_Homo sapiens_hsa005100.30616383
109Caffeine metabolism_Homo sapiens_hsa002320.29914095
110Retinol metabolism_Homo sapiens_hsa008300.29349518
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28663759
112Chemical carcinogenesis_Homo sapiens_hsa052040.28452851
113Metabolic pathways_Homo sapiens_hsa011000.27972153
114Hippo signaling pathway_Homo sapiens_hsa043900.27395372
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27321326
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27161618
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26799729
118Prostate cancer_Homo sapiens_hsa052150.26105562
119Linoleic acid metabolism_Homo sapiens_hsa005910.25505474
120Melanoma_Homo sapiens_hsa052180.25313661
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23743986
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23143646
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22938475
124Vibrio cholerae infection_Homo sapiens_hsa051100.22492714
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.21394568
126Small cell lung cancer_Homo sapiens_hsa052220.20071612
127beta-Alanine metabolism_Homo sapiens_hsa004100.20023313
128T cell receptor signaling pathway_Homo sapiens_hsa046600.19803633
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19550213
130Thyroid cancer_Homo sapiens_hsa052160.18353656
131Apoptosis_Homo sapiens_hsa042100.18110364
132Arginine and proline metabolism_Homo sapiens_hsa003300.17929611
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17768936
134Biosynthesis of amino acids_Homo sapiens_hsa012300.17502262
135Morphine addiction_Homo sapiens_hsa050320.17090341
136Hedgehog signaling pathway_Homo sapiens_hsa043400.15227290
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.14595740
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14004446
139Dopaminergic synapse_Homo sapiens_hsa047280.13198847
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13046715
141GABAergic synapse_Homo sapiens_hsa047270.11598161
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.11327157
143Rheumatoid arthritis_Homo sapiens_hsa053230.10800340

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