RBM43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.14819394
2ribosomal small subunit assembly (GO:0000028)5.78521275
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.37334297
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.37334297
5definitive hemopoiesis (GO:0060216)5.08090086
6antigen processing and presentation of endogenous antigen (GO:0019883)4.73679600
7DNA deamination (GO:0045006)4.55414464
8antigen processing and presentation via MHC class Ib (GO:0002475)4.36128228
9behavioral response to nicotine (GO:0035095)4.16172109
10positive regulation of gamma-delta T cell activation (GO:0046645)4.12751427
11response to interferon-beta (GO:0035456)4.06558459
12positive regulation of B cell differentiation (GO:0045579)3.99125462
13viral transcription (GO:0019083)3.89018143
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.82107046
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77031144
16cilium or flagellum-dependent cell motility (GO:0001539)3.76284257
17tryptophan catabolic process (GO:0006569)3.73679671
18indole-containing compound catabolic process (GO:0042436)3.73679671
19indolalkylamine catabolic process (GO:0046218)3.73679671
20translational termination (GO:0006415)3.71726020
21cellular response to exogenous dsRNA (GO:0071360)3.69710166
22negative regulation of erythrocyte differentiation (GO:0045647)3.63738559
23daunorubicin metabolic process (GO:0044597)3.61824813
24polyketide metabolic process (GO:0030638)3.61824813
25doxorubicin metabolic process (GO:0044598)3.61824813
26platelet dense granule organization (GO:0060155)3.58027523
27negative regulation of mast cell activation (GO:0033004)3.57388020
28megakaryocyte development (GO:0035855)3.56690125
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51597517
30positive regulation of defense response to virus by host (GO:0002230)3.44633025
31telomere maintenance via semi-conservative replication (GO:0032201)3.43978952
32cotranslational protein targeting to membrane (GO:0006613)3.43590507
33sulfation (GO:0051923)3.42147713
34axonemal dynein complex assembly (GO:0070286)3.41111768
35protein targeting to ER (GO:0045047)3.40250058
36cellular response to type I interferon (GO:0071357)3.39690880
37type I interferon signaling pathway (GO:0060337)3.39690880
38response to type I interferon (GO:0034340)3.38204657
39translational elongation (GO:0006414)3.36370473
40defense response to protozoan (GO:0042832)3.35659075
41response to interferon-alpha (GO:0035455)3.31003552
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30212892
43regulation of B cell receptor signaling pathway (GO:0050855)3.28029436
44cellular response to interferon-beta (GO:0035458)3.24487140
45protein localization to endoplasmic reticulum (GO:0070972)3.24468502
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23433813
47kynurenine metabolic process (GO:0070189)3.23403714
48regulation of B cell differentiation (GO:0045577)3.22648119
49response to pheromone (GO:0019236)3.18554958
50negative regulation of telomere maintenance (GO:0032205)3.16001582
51response to protozoan (GO:0001562)3.15664830
52tryptophan metabolic process (GO:0006568)3.14357430
53regulation of erythrocyte differentiation (GO:0045646)3.12925050
54immunoglobulin mediated immune response (GO:0016064)3.12307199
55necroptotic process (GO:0070266)3.11489695
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11306585
57cilium movement (GO:0003341)3.11119577
58tolerance induction (GO:0002507)3.09907391
59T cell homeostasis (GO:0043029)3.08582288
60mast cell activation (GO:0045576)3.08532173
61lymph node development (GO:0048535)3.07122790
62DNA strand elongation involved in DNA replication (GO:0006271)3.05364305
63ribosomal small subunit biogenesis (GO:0042274)3.03992486
64protein K11-linked deubiquitination (GO:0035871)3.02250814
65purine-containing compound salvage (GO:0043101)3.02005631
66maturation of SSU-rRNA (GO:0030490)3.00995144
67L-fucose catabolic process (GO:0042355)3.00687660
68fucose catabolic process (GO:0019317)3.00687660
69L-fucose metabolic process (GO:0042354)3.00687660
70epithelial cilium movement (GO:0003351)3.00412587
71telomere maintenance via recombination (GO:0000722)2.99032119
72regulation of necroptotic process (GO:0060544)2.98816323
73DNA strand elongation (GO:0022616)2.97268001
74regulation of gamma-delta T cell differentiation (GO:0045586)2.96489713
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95121597
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.93905668
77cellular response to ATP (GO:0071318)2.93884196
78indolalkylamine metabolic process (GO:0006586)2.93697336
79mature B cell differentiation involved in immune response (GO:0002313)2.93557787
80positive regulation of cAMP-mediated signaling (GO:0043950)2.92588886
81endosome to melanosome transport (GO:0035646)2.91376205
82endosome to pigment granule transport (GO:0043485)2.91376205
83regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.91183129
84interferon-gamma production (GO:0032609)2.89278978
85viral life cycle (GO:0019058)2.86113441
86axoneme assembly (GO:0035082)2.85263152
87myeloid dendritic cell activation (GO:0001773)2.85240017
88B cell mediated immunity (GO:0019724)2.84541201
89cellular protein complex disassembly (GO:0043624)2.82110072
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82063865
91positive regulation of granulocyte differentiation (GO:0030854)2.81901178
92interferon-gamma-mediated signaling pathway (GO:0060333)2.81226502
93actin nucleation (GO:0045010)2.79752320
94regulation of memory T cell differentiation (GO:0043380)2.79617553
95detection of light stimulus involved in visual perception (GO:0050908)2.78454052
96detection of light stimulus involved in sensory perception (GO:0050962)2.78454052
97cellular response to zinc ion (GO:0071294)2.77259996
98B cell receptor signaling pathway (GO:0050853)2.77149618
99Peyers patch development (GO:0048541)2.73894016
100mucosal-associated lymphoid tissue development (GO:0048537)2.73894016
101response to interleukin-15 (GO:0070672)2.73336108
102leukocyte aggregation (GO:0070486)2.72872791
103positive regulation of natural killer cell differentiation (GO:0032825)2.71977263
104regulation of gamma-delta T cell activation (GO:0046643)2.71494149
105regulation of T cell mediated cytotoxicity (GO:0001914)2.71281984
106negative regulation of viral genome replication (GO:0045071)2.70882943
107secretory granule organization (GO:0033363)2.68565380
108negative regulation of phagocytosis (GO:0050765)2.68316286
109neural tube formation (GO:0001841)2.67931448
110cellular response to ethanol (GO:0071361)2.66724443
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66710780
112lymphoid progenitor cell differentiation (GO:0002320)2.65818515
113mitotic recombination (GO:0006312)2.65170229
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65043766
115programmed necrotic cell death (GO:0097300)2.64915955
116mast cell activation involved in immune response (GO:0002279)2.64717082
117mast cell degranulation (GO:0043303)2.64717082
118regulation of T cell receptor signaling pathway (GO:0050856)2.62873134
119activated T cell proliferation (GO:0050798)2.62787782
120mature B cell differentiation (GO:0002335)2.62534912
121positive regulation of macrophage differentiation (GO:0045651)2.60842936
122endoderm formation (GO:0001706)2.60157672
123positive regulation of lamellipodium assembly (GO:0010592)2.59789721
124translational initiation (GO:0006413)2.59168406
125protein-cofactor linkage (GO:0018065)2.58594800
126regulation of natural killer cell differentiation (GO:0032823)2.55823405
127regulation of germinal center formation (GO:0002634)2.55532459
128positive regulation of interferon-alpha production (GO:0032727)2.54374114
129phosphatidylinositol acyl-chain remodeling (GO:0036149)2.53852761
130regulation of necrotic cell death (GO:0010939)2.53792265
131regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53332451
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52624956
133protein complex disassembly (GO:0043241)2.51024336
134embryonic hemopoiesis (GO:0035162)2.50655617
135DNA replication initiation (GO:0006270)2.49945362
136water-soluble vitamin biosynthetic process (GO:0042364)2.49847506
137negative regulation by host of viral transcription (GO:0043922)2.49732963
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49650841
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.49650841
140regulation of translation, ncRNA-mediated (GO:0045974)2.49650841
141telomere maintenance via telomere lengthening (GO:0010833)2.48798596
142positive regulation of T-helper 1 type immune response (GO:0002827)2.48673713
143regulation of regulatory T cell differentiation (GO:0045589)2.46666916
144regulation of thymocyte apoptotic process (GO:0070243)2.46087203
145preassembly of GPI anchor in ER membrane (GO:0016254)2.43994953
146cAMP catabolic process (GO:0006198)2.41465794
147parturition (GO:0007567)2.41455294
148exogenous drug catabolic process (GO:0042738)2.38266817
149regulation of T-helper 1 type immune response (GO:0002825)2.37975666
150head development (GO:0060322)2.37661043
151amine catabolic process (GO:0009310)2.36060010
152cellular biogenic amine catabolic process (GO:0042402)2.36060010
153negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.35454292
154negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34394812
155negative regulation of cell killing (GO:0031342)2.34394812
156reflex (GO:0060004)2.33774704
157positive regulation of fatty acid transport (GO:2000193)2.32912822
158motile cilium assembly (GO:0044458)2.32300619
159positive regulation of triglyceride biosynthetic process (GO:0010867)2.31952562
160negative regulation of interleukin-1 production (GO:0032692)2.30474584
161cellular ketone body metabolic process (GO:0046950)2.30094872
162regulation of sequestering of triglyceride (GO:0010889)2.28343863
163negative regulation of interleukin-1 beta production (GO:0032691)2.28189586
164negative regulation of T cell mediated immunity (GO:0002710)2.27102842
165regulation of defense response to virus by host (GO:0050691)2.26932786
166drug catabolic process (GO:0042737)2.25794497
167retinal cone cell development (GO:0046549)2.24790780
168positive regulation of T cell mediated cytotoxicity (GO:0001916)2.23605585
169negative T cell selection (GO:0043383)2.22897587
170response to xenobiotic stimulus (GO:0009410)2.22540712
171cytidine deamination (GO:0009972)2.22127301
172cytidine metabolic process (GO:0046087)2.22127301
173cytidine catabolic process (GO:0006216)2.22127301
174cilium organization (GO:0044782)2.21522833
175cytokine biosynthetic process (GO:0042089)2.21032540
176macroautophagy (GO:0016236)2.20764145
177cyclic nucleotide catabolic process (GO:0009214)2.18306674
178positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.17497195
179regulation of isotype switching to IgG isotypes (GO:0048302)2.15896731
180positive regulation of antigen processing and presentation (GO:0002579)2.15494327
181regulation of MHC class I biosynthetic process (GO:0045343)2.15474670
182negative thymic T cell selection (GO:0045060)2.15059707
183positive regulation of heat generation (GO:0031652)2.14640478
184positive regulation of toll-like receptor signaling pathway (GO:0034123)2.13957716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.02546839
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.02731599
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.64070728
4SCL_19346495_ChIP-Seq_HPC-7_Human3.51505221
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29992766
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15991145
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.14419871
8ZNF274_21170338_ChIP-Seq_K562_Hela3.02856870
9GATA1_22025678_ChIP-Seq_K562_Human3.02842627
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85001387
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79736606
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.74369084
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.72869500
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72505233
15GBX2_23144817_ChIP-Seq_PC3_Human2.64623347
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63680796
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.57585264
18VDR_22108803_ChIP-Seq_LS180_Human2.53143317
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.52549833
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52113814
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46220804
22* MYC_18555785_ChIP-Seq_MESCs_Mouse2.34990446
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26510569
24SPI1_23547873_ChIP-Seq_NB4_Human2.22634548
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15209762
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14806937
27MYC_22102868_ChIP-Seq_BL_Human2.13085401
28ERG_20887958_ChIP-Seq_HPC-7_Mouse2.12110211
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11122420
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.09858176
31HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08276553
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.07539845
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07511944
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.03436316
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02325538
36EGR1_19374776_ChIP-ChIP_THP-1_Human2.01685366
37MYB_26560356_Chip-Seq_TH2_Human2.01588007
38EST1_17652178_ChIP-ChIP_JURKAT_Human2.01486288
39POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00744829
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99396010
41VDR_21846776_ChIP-Seq_THP-1_Human1.97629949
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.95942923
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95592156
44VDR_23849224_ChIP-Seq_CD4+_Human1.94803795
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94687647
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.92110399
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91494090
48ER_23166858_ChIP-Seq_MCF-7_Human1.87627555
49EWS_26573619_Chip-Seq_HEK293_Human1.83783756
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80894677
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76768766
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.76436324
53FUS_26573619_Chip-Seq_HEK293_Human1.76243447
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75190761
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74686986
56* IRF8_27001747_Chip-Seq_BMDM_Mouse1.74632009
57FOXP3_21729870_ChIP-Seq_TREG_Human1.74437077
58MYB_26560356_Chip-Seq_TH1_Human1.74424123
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72300100
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.71866089
61IGF1R_20145208_ChIP-Seq_DFB_Human1.71801448
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68893302
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68056747
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67822367
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67356310
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66608661
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65146461
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.64569159
69* P300_19829295_ChIP-Seq_ESCs_Human1.63088965
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62603551
71MAF_26560356_Chip-Seq_TH1_Human1.61981996
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.60484154
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60275709
74VDR_24763502_ChIP-Seq_THP-1_Human1.60111953
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59076909
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58674267
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58403219
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58316706
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.57794572
80BCAT_22108803_ChIP-Seq_LS180_Human1.57177412
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55523659
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55348155
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52287198
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50349308
85TAF15_26573619_Chip-Seq_HEK293_Human1.48023629
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.46956600
87CIITA_25753668_ChIP-Seq_RAJI_Human1.46574775
88* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44958009
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43898004
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43178652
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42794046
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42379317
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41293807
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39003633
95SMAD4_21799915_ChIP-Seq_A2780_Human1.38657165
96* STAT3_23295773_ChIP-Seq_U87_Human1.38427015
97ELK1_19687146_ChIP-ChIP_HELA_Human1.37982125
98AR_25329375_ChIP-Seq_VCAP_Human1.36610473
99UTX_26944678_Chip-Seq_JUKART_Human1.36504767
100RUNX_20019798_ChIP-Seq_JUKART_Human1.35726611
101* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35690185
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35476184
103* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33979005
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33106139
105XRN2_22483619_ChIP-Seq_HELA_Human1.32732733
106TP53_16413492_ChIP-PET_HCT116_Human1.32367305
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32276541
108DCP1A_22483619_ChIP-Seq_HELA_Human1.32122452
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30993725
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.30037639
111CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29267071
112IRF1_19129219_ChIP-ChIP_H3396_Human1.29232128
113* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28965401
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28481941
115CBP_20019798_ChIP-Seq_JUKART_Human1.27298953
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27298953
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.25768667
118GABP_19822575_ChIP-Seq_HepG2_Human1.25645744
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25184581
120MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25157506
121* TCF4_23295773_ChIP-Seq_U87_Human1.23698910
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.23025269
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.22797159
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22001064
125GATA1_19941827_ChIP-Seq_MEL_Mouse1.21734698
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21373517
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21373517
128E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20878943
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20592151
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20263312
131NANOG_19829295_ChIP-Seq_ESCs_Human1.20152834
132SOX2_19829295_ChIP-Seq_ESCs_Human1.20152834
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.19839195
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19793576
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19573063
136SPI1_23127762_ChIP-Seq_K562_Human1.18274332
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.18250076
138BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17666875
139GATA3_21878914_ChIP-Seq_MCF-7_Human1.17444663
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17029813
141NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17012379
142TP53_22573176_ChIP-Seq_HFKS_Human1.16383614
143FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16156043
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.16156043
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13828525
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13459248
147CRX_20693478_ChIP-Seq_RETINA_Mouse1.13195994
148TCF4_22108803_ChIP-Seq_LS180_Human1.12821785
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12355338
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11696295
151AR_20517297_ChIP-Seq_VCAP_Human1.11597363
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11530810
153SMAD4_21741376_ChIP-Seq_EPCs_Human1.11285119
154CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10848681
155TCF7_22412390_ChIP-Seq_EML_Mouse1.10784516
156VDR_24787735_ChIP-Seq_THP-1_Human1.09027377
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08974540
158EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08894363
159GATA3_27048872_Chip-Seq_THYMUS_Human1.08876758
160ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07963008
161CDX2_22108803_ChIP-Seq_LS180_Human1.07789044
162ARNT_22903824_ChIP-Seq_MCF-7_Human1.07672738
163FOXM1_23109430_ChIP-Seq_U2OS_Human1.07155884
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06236455
165* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05754920
166* NANOG_18555785_Chip-Seq_ESCs_Mouse1.05615530
167SMRT_27268052_Chip-Seq_Bcells_Human1.05549504
168* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04608485
169GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04327389
170CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03684936
171* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02878024
172MYC_18940864_ChIP-ChIP_HL60_Human1.02846652
173MAF_26560356_Chip-Seq_TH2_Human1.02033416
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01983065
175AHR_22903824_ChIP-Seq_MCF-7_Human1.01187197
176* P53_22387025_ChIP-Seq_ESCs_Mouse1.00509377
177CBX2_27304074_Chip-Seq_ESCs_Mouse0.99962427
178FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99954632
179OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99263131
180PU_27001747_Chip-Seq_BMDM_Mouse0.98770231
181* TTF2_22483619_ChIP-Seq_HELA_Human0.97994035
182TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97689282
183FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97029652
184GATA3_26560356_Chip-Seq_TH2_Human0.96942383
185ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95269488
186* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93217787
187THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90394640
188RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88188247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.97931409
2MP0002396_abnormal_hematopoietic_system3.63702849
3MP0000685_abnormal_immune_system3.29626408
4MP0009785_altered_susceptibility_to3.28859537
5MP0005671_abnormal_response_to3.17302082
6MP0003195_calcinosis3.09202502
7MP0003724_increased_susceptibility_to2.98998285
8MP0005397_hematopoietic_system_phenotyp2.83839995
9MP0001545_abnormal_hematopoietic_system2.83839995
10MP0008875_abnormal_xenobiotic_pharmacok2.80948787
11MP0003763_abnormal_thymus_physiology2.70999247
12MP0004808_abnormal_hematopoietic_stem2.54648880
13MP0001800_abnormal_humoral_immune2.53847992
14MP0002398_abnormal_bone_marrow2.49540260
15MP0005025_abnormal_response_to2.49330857
16MP0002876_abnormal_thyroid_physiology2.48524850
17MP0005000_abnormal_immune_tolerance2.47416092
18MP0003436_decreased_susceptibility_to2.39260020
19MP0002148_abnormal_hypersensitivity_rea2.36661393
20MP0005464_abnormal_platelet_physiology2.35630210
21MP0002452_abnormal_antigen_presenting2.34989405
22MP0002420_abnormal_adaptive_immunity2.34491945
23MP0002723_abnormal_immune_serum2.32510143
24MP0001819_abnormal_immune_cell2.32044223
25MP0002166_altered_tumor_susceptibility2.27433781
26MP0005174_abnormal_tail_pigmentation2.21536354
27MP0001790_abnormal_immune_system2.20338239
28MP0005387_immune_system_phenotype2.20338239
29MP0002419_abnormal_innate_immunity2.13882256
30MP0000716_abnormal_immune_system2.07796688
31MP0004147_increased_porphyrin_level2.05111779
32MP0000689_abnormal_spleen_morphology2.04789035
33MP0005075_abnormal_melanosome_morpholog2.04539137
34MP0000490_abnormal_crypts_of2.03703335
35MP0002928_abnormal_bile_duct2.01782204
36MP0006054_spinal_hemorrhage2.00130027
37MP0000569_abnormal_digit_pigmentation1.99733705
38MP0001853_heart_inflammation1.99211074
39MP0002722_abnormal_immune_system1.97118012
40MP0002277_abnormal_respiratory_mucosa1.95447578
41MP0004885_abnormal_endolymph1.93051300
42MP0002006_tumorigenesis1.90561482
43MP0002138_abnormal_hepatobiliary_system1.89902853
44MP0002429_abnormal_blood_cell1.89462862
45MP0009333_abnormal_splenocyte_physiolog1.85497468
46MP0008872_abnormal_physiological_respon1.80492500
47MP0010155_abnormal_intestine_physiology1.80320005
48MP0003656_abnormal_erythrocyte_physiolo1.79920170
49MP0002653_abnormal_ependyma_morphology1.76714985
50MP0000465_gastrointestinal_hemorrhage1.75501158
51MP0010094_abnormal_chromosome_stability1.73721414
52MP0003866_abnormal_defecation1.73676929
53MP0001873_stomach_inflammation1.72223658
54MP0002405_respiratory_system_inflammati1.71645929
55MP0004043_abnormal_pH_regulation1.69182922
56MP0008058_abnormal_DNA_repair1.66087218
57MP0000703_abnormal_thymus_morphology1.65292504
58MP0000427_abnormal_hair_cycle1.60664744
59MP0002095_abnormal_skin_pigmentation1.59907079
60MP0005551_abnormal_eye_electrophysiolog1.59234869
61MP0001845_abnormal_inflammatory_respons1.55687365
62MP0003806_abnormal_nucleotide_metabolis1.53852278
63MP0001986_abnormal_taste_sensitivity1.53510541
64MP0001485_abnormal_pinna_reflex1.53500906
65MP0003646_muscle_fatigue1.52356588
66MP0005084_abnormal_gallbladder_morpholo1.47382790
67MP0003136_yellow_coat_color1.46782064
68MP0003693_abnormal_embryo_hatching1.46233208
69MP0001501_abnormal_sleep_pattern1.46156438
70MP0002877_abnormal_melanocyte_morpholog1.44909798
71MP0003191_abnormal_cellular_cholesterol1.44702567
72MP0000015_abnormal_ear_pigmentation1.43082408
73MP0008469_abnormal_protein_level1.39338731
74MP0002163_abnormal_gland_morphology1.38661340
75MP0004142_abnormal_muscle_tone1.37538193
76MP0008007_abnormal_cellular_replicative1.37083713
77MP0002102_abnormal_ear_morphology1.35170526
78MP0001542_abnormal_bone_strength1.34578947
79MP0006072_abnormal_retinal_apoptosis1.32001658
80MP0009278_abnormal_bone_marrow1.30258400
81MP0000383_abnormal_hair_follicle1.28736901
82MP0001533_abnormal_skeleton_physiology1.23944005
83MP0003303_peritoneal_inflammation1.23654073
84MP0003252_abnormal_bile_duct1.23093017
85MP0004742_abnormal_vestibular_system1.22786355
86MP0002019_abnormal_tumor_incidence1.19041736
87MP0002132_abnormal_respiratory_system1.18219638
88MP0006082_CNS_inflammation1.17260355
89MP0003077_abnormal_cell_cycle1.15297191
90MP0005253_abnormal_eye_physiology1.14309305
91MP0008057_abnormal_DNA_replication1.13293434
92MP0003172_abnormal_lysosome_physiology1.11727061
93MP0009764_decreased_sensitivity_to1.11178935
94MP0003011_delayed_dark_adaptation1.11156430
95MP0004947_skin_inflammation1.10276134
96MP0000858_altered_metastatic_potential1.09870435
97MP0004130_abnormal_muscle_cell1.09146064
98MP0003943_abnormal_hepatobiliary_system1.07982797
99MP0005389_reproductive_system_phenotype1.07831979
100MP0004883_abnormal_blood_vessel1.05265085
101MP0000230_abnormal_systemic_arterial1.05188533
102MP0002282_abnormal_trachea_morphology1.02586167
103MP0005164_abnormal_response_to1.00819575
104MP0005503_abnormal_tendon_morphology1.00568614
105MP0000372_irregular_coat_pigmentation0.99207738
106MP0001968_abnormal_touch/_nociception0.98347803
107MP0004957_abnormal_blastocyst_morpholog0.98240075
108MP0004133_heterotaxia0.97061649
109MP0010386_abnormal_urinary_bladder0.97031077
110MP0000343_altered_response_to0.96352540
111MP0003300_gastrointestinal_ulcer0.96156981
112MP0003045_fibrosis0.94684439
113MP0009745_abnormal_behavioral_response0.92948829
114MP0003111_abnormal_nucleus_morphology0.90757762
115MP0003186_abnormal_redox_activity0.90287512
116MP0002638_abnormal_pupillary_reflex0.89069753
117MP0003787_abnormal_imprinting0.88825488
118MP0001919_abnormal_reproductive_system0.88734091
119MP0005646_abnormal_pituitary_gland0.86679332
120MP0000313_abnormal_cell_death0.86087083
121MP0005390_skeleton_phenotype0.81529204
122MP0003075_altered_response_to0.80473270
123MP0004145_abnormal_muscle_electrophysio0.79347734
124MP0006036_abnormal_mitochondrial_physio0.77119972
125MP0009379_abnormal_foot_pigmentation0.76913675
126MP0000631_abnormal_neuroendocrine_gland0.76406957
127MP0005448_abnormal_energy_balance0.76168545
128MP0000470_abnormal_stomach_morphology0.76053218
129MP0005085_abnormal_gallbladder_physiolo0.75787223
130MP0002139_abnormal_hepatobiliary_system0.75619910
131MP0002933_joint_inflammation0.74156746
132MP0009763_increased_sensitivity_to0.73917568
133MP0001663_abnormal_digestive_system0.73592775
134MP0005310_abnormal_salivary_gland0.73036552
135MP0003950_abnormal_plasma_membrane0.72760578
136MP0005379_endocrine/exocrine_gland_phen0.72327469
137MP0001348_abnormal_lacrimal_gland0.72077025
138MP0002136_abnormal_kidney_physiology0.71231707
139MP0000681_abnormal_thyroid_gland0.70872528
140MP0002837_dystrophic_cardiac_calcinosis0.70663443
141MP0001188_hyperpigmentation0.70355186
142MP0004510_myositis0.65648106
143MP0005058_abnormal_lysosome_morphology0.65035165
144MP0002693_abnormal_pancreas_physiology0.64662302
145MP0009765_abnormal_xenobiotic_induced0.64085950
146MP0001764_abnormal_homeostasis0.59622096
147MP0003638_abnormal_response/metabolism_0.59524260
148MP0000477_abnormal_intestine_morphology0.55380539
149MP0010307_abnormal_tumor_latency0.54871010
150MP0006292_abnormal_olfactory_placode0.54477841
151MP0010352_gastrointestinal_tract_polyps0.52539846
152MP0008877_abnormal_DNA_methylation0.52372757
153MP0005636_abnormal_mineral_homeostasis0.51631524
154MP0003448_altered_tumor_morphology0.50136036
155MP0000598_abnormal_liver_morphology0.50113919

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.84234309
2Abnormal number of erythroid precursors (HP:0012131)4.83176611
3Aplastic anemia (HP:0001915)4.80588057
4Abnormality of cells of the erythroid lineage (HP:0012130)4.68996447
5Pancreatic cysts (HP:0001737)4.65183926
6Chronic otitis media (HP:0000389)4.50728937
7Thrombocytosis (HP:0001894)4.45595997
8Molar tooth sign on MRI (HP:0002419)4.35864620
9Abnormality of midbrain morphology (HP:0002418)4.35864620
10Abnormality of the heme biosynthetic pathway (HP:0010472)4.25089949
11Petechiae (HP:0000967)4.24062322
12True hermaphroditism (HP:0010459)4.23783547
13Pancreatic fibrosis (HP:0100732)4.16248165
14Elevated erythrocyte sedimentation rate (HP:0003565)3.91911831
15Recurrent abscess formation (HP:0002722)3.83513827
16Nephronophthisis (HP:0000090)3.81235578
17Prolonged bleeding time (HP:0003010)3.78983086
18Recurrent bronchitis (HP:0002837)3.75072273
19Myositis (HP:0100614)3.63986391
20Abnormality of T cell physiology (HP:0011840)3.43236347
21Recurrent bacterial skin infections (HP:0005406)3.38069210
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.29911108
23Absent/shortened dynein arms (HP:0200106)3.29911108
24Abnormality of the renal medulla (HP:0100957)3.22862698
25Abnormality of the renal cortex (HP:0011035)3.22085595
26Congenital stationary night blindness (HP:0007642)3.20909381
27Stomatitis (HP:0010280)3.18198079
28Recurrent viral infections (HP:0004429)3.11757337
29Severe combined immunodeficiency (HP:0004430)3.04855175
30Nasal polyposis (HP:0100582)3.03477204
31Abnormality of the nasal mucosa (HP:0000433)2.99594139
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.99568502
33Epistaxis (HP:0000421)2.98217523
34Reticulocytopenia (HP:0001896)2.98207211
35Abnormality of T cells (HP:0002843)2.95513790
36Type II lissencephaly (HP:0007260)2.95488309
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.93881405
38Abnormal respiratory epithelium morphology (HP:0012253)2.91772845
39Abnormal respiratory motile cilium morphology (HP:0005938)2.91772845
40Chronic hepatic failure (HP:0100626)2.90826788
41Congenital sensorineural hearing impairment (HP:0008527)2.90343989
42Cystic liver disease (HP:0006706)2.88833545
43Recurrent fungal infections (HP:0002841)2.84597980
44Abnormal ciliary motility (HP:0012262)2.81011363
45Eczematoid dermatitis (HP:0000976)2.80794869
46Reduced antithrombin III activity (HP:0001976)2.78899426
47Cellulitis (HP:0100658)2.77918587
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75055222
49Abnormal respiratory motile cilium physiology (HP:0012261)2.74295770
50Panhypogammaglobulinemia (HP:0003139)2.72263672
51Lymphoma (HP:0002665)2.71369156
52Pallor (HP:0000980)2.69605037
53Type I transferrin isoform profile (HP:0003642)2.67539073
54Furrowed tongue (HP:0000221)2.67144110
55Lymphopenia (HP:0001888)2.66974001
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.66401176
57IgG deficiency (HP:0004315)2.64154210
58Tubular atrophy (HP:0000092)2.63133279
59Concave nail (HP:0001598)2.61654677
60Genetic anticipation (HP:0003743)2.60512521
61Meningitis (HP:0001287)2.59451110
62Attenuation of retinal blood vessels (HP:0007843)2.56926106
63Eosinophilia (HP:0001880)2.55453086
64Interstitial pulmonary disease (HP:0006530)2.55024142
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.54462299
66Myelodysplasia (HP:0002863)2.54092067
67Gastrointestinal stroma tumor (HP:0100723)2.52557034
68Keratoconus (HP:0000563)2.52048780
69Increased corneal curvature (HP:0100692)2.52048780
70Chronic sinusitis (HP:0011109)2.52021068
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.50207018
72Abnormal rod and cone electroretinograms (HP:0008323)2.48923080
73Mediastinal lymphadenopathy (HP:0100721)2.47917850
74Abnormality of macrophages (HP:0004311)2.47852375
75Vasculitis (HP:0002633)2.47125194
76Abolished electroretinogram (ERG) (HP:0000550)2.46642093
77Congenital, generalized hypertrichosis (HP:0004540)2.46616838
78Recurrent skin infections (HP:0001581)2.44715470
79Abnormality of B cell number (HP:0010975)2.41586220
80B lymphocytopenia (HP:0010976)2.41586220
81Neutropenia (HP:0001875)2.40783424
82Hypothermia (HP:0002045)2.40703440
83Stomach cancer (HP:0012126)2.38797098
84Bronchitis (HP:0012387)2.38375651
85Pendular nystagmus (HP:0012043)2.37511344
86Abnormal platelet function (HP:0011869)2.35636942
87Impaired platelet aggregation (HP:0003540)2.35636942
88Rhinitis (HP:0012384)2.33917507
89Decreased circulating renin level (HP:0003351)2.32952585
90Autoimmune thrombocytopenia (HP:0001973)2.32110336
91Abnormal protein glycosylation (HP:0012346)2.31755982
92Abnormal glycosylation (HP:0012345)2.31755982
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31755982
94Abnormal protein N-linked glycosylation (HP:0012347)2.31755982
95Agammaglobulinemia (HP:0004432)2.30065820
96Hypoplasia of the thymus (HP:0000778)2.29175022
97Medial flaring of the eyebrow (HP:0010747)2.28906039
9811 pairs of ribs (HP:0000878)2.28715928
99Inflammation of the large intestine (HP:0002037)2.27609449
100Pancytopenia (HP:0001876)2.26841837
101Orchitis (HP:0100796)2.26650820
102Gastrointestinal inflammation (HP:0004386)2.26117246
103Type 2 muscle fiber atrophy (HP:0003554)2.24595294
104Large for gestational age (HP:0001520)2.23023929
105Spontaneous hematomas (HP:0007420)2.21408332
106Abnormality of eosinophils (HP:0001879)2.20567149
107Decreased central vision (HP:0007663)2.19257435
108Aplasia/Hypoplasia of the tongue (HP:0010295)2.17135743
109Sclerocornea (HP:0000647)2.16465720
110Renal cortical cysts (HP:0000803)2.16201905
111Progressive cerebellar ataxia (HP:0002073)2.14935393
112Muscle fiber atrophy (HP:0100295)2.14751401
113Abnormal drinking behavior (HP:0030082)2.14578752
114Polydipsia (HP:0001959)2.14578752
115Congenital hepatic fibrosis (HP:0002612)2.14295755
116Increased cerebral lipofuscin (HP:0011813)2.14270926
117Bronchiectasis (HP:0002110)2.14133959
118Chronic diarrhea (HP:0002028)2.13168481
119Encephalitis (HP:0002383)2.13082248
120Hematochezia (HP:0002573)2.12886416
121Male pseudohermaphroditism (HP:0000037)2.11523346
122Hypoproteinemia (HP:0003075)2.10974746
123Poikiloderma (HP:0001029)2.10667251
124Obstructive lung disease (HP:0006536)2.08290242
125Chronic obstructive pulmonary disease (HP:0006510)2.08290242
126Gingival bleeding (HP:0000225)2.07415019
127T lymphocytopenia (HP:0005403)2.07295628
128Osteomyelitis (HP:0002754)2.06903292
129Acute myeloid leukemia (HP:0004808)2.06844035
130Autoimmune hemolytic anemia (HP:0001890)2.05235599
131Asplenia (HP:0001746)2.04826150
132Hypergammaglobulinemia (HP:0010702)2.03381086
133Thyroiditis (HP:0100646)2.01811938
134IgA deficiency (HP:0002720)2.01157290
135Purpura (HP:0000979)2.00728729
136Microcytic anemia (HP:0001935)2.00199949
137Anencephaly (HP:0002323)1.99371135
138Recurrent sinusitis (HP:0011108)1.99234300
139Abnormality of T cell number (HP:0011839)1.99194400
140Albinism (HP:0001022)1.98966504
141Combined immunodeficiency (HP:0005387)1.98896397
142Recurrent cutaneous fungal infections (HP:0011370)1.95934679
143Chronic mucocutaneous candidiasis (HP:0002728)1.95934679
144Bone marrow hypocellularity (HP:0005528)1.95434327
1453-Methylglutaconic aciduria (HP:0003535)1.94470182
146Recurrent gram-negative bacterial infections (HP:0005420)1.92982670
147Spinal cord lesions (HP:0100561)1.92734085
148Syringomyelia (HP:0003396)1.92734085
149Birth length less than 3rd percentile (HP:0003561)1.91883082
150Abnormality of the pons (HP:0007361)1.91860637
151Amaurosis fugax (HP:0100576)1.91383523
152Chorioretinal atrophy (HP:0000533)1.90295580
153Retrobulbar optic neuritis (HP:0100654)1.90058589
154Optic neuritis (HP:0100653)1.90058589
155Leukocytosis (HP:0001974)1.89615511
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89266413
157Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89266413
158Macrocytic anemia (HP:0001972)1.89108406
159Esophageal neoplasm (HP:0100751)1.88772172
160Neoplasm of head and neck (HP:0012288)1.88772172
161Polyuria (HP:0000103)1.87017350
162Constricted visual fields (HP:0001133)1.85309661
163Inability to walk (HP:0002540)1.85294544
164Hypoplasia of the uterus (HP:0000013)1.83535016
165Severe muscular hypotonia (HP:0006829)1.83281812
166Keratoconjunctivitis (HP:0001096)1.82931598
167Postaxial foot polydactyly (HP:0001830)1.81197159
168Hypoplasia of the pons (HP:0012110)1.77221067
169Congenital primary aphakia (HP:0007707)1.76740932
170Hemoptysis (HP:0002105)1.76611265
171Hyperventilation (HP:0002883)1.76237709
172Pulmonary infiltrates (HP:0002113)1.74985167
173Occipital encephalocele (HP:0002085)1.72783025
174Granulocytopenia (HP:0001913)1.72242255
175Nephrogenic diabetes insipidus (HP:0009806)1.72067029
176Gait imbalance (HP:0002141)1.71095932
177Aplasia/hypoplasia of the uterus (HP:0008684)1.70434428
178Chronic bronchitis (HP:0004469)1.68382872
179Methylmalonic acidemia (HP:0002912)1.67243736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34180384
2MAP4K13.57370392
3KIT2.95673578
4MAP3K122.57223109
5FLT32.45160044
6TEC2.43775473
7STK162.39884414
8ZAP702.36852449
9MAPK152.34955803
10GRK12.33586864
11TXK2.23826498
12BTK2.23466623
13WNK32.21867358
14TBK12.14303955
15INSRR2.11929782
16IRAK42.07981223
17NME22.07792211
18JAK32.04777284
19MAPKAPK52.03547966
20MAP2K32.03345704
21IKBKE1.93218330
22NUAK11.84081909
23PIM21.82880754
24RIPK41.82574979
25TGFBR11.77150405
26SCYL21.75542837
27CSF1R1.74677137
28TYK21.74060980
29PINK11.72752123
30WEE11.71699087
31BLK1.69054676
32SYK1.66387764
33MKNK11.65715978
34GRK71.65248928
35EEF2K1.58587913
36MATK1.57899591
37ACVR1B1.57391738
38CDK191.54131901
39MAP4K21.51709013
40CCNB11.48133344
41TNK21.44037314
42EIF2AK11.41860623
43DAPK21.40710217
44ADRBK11.38975966
45CDC71.38636424
46WNK41.29101201
47KDR1.28035325
48IRAK11.27397492
49VRK11.23204548
50ZAK1.22997833
51RPS6KA41.22371511
52OXSR11.21569753
53BRSK21.20526583
54TNIK1.18332445
55MUSK1.16763434
56TGFBR21.16164123
57MAPK131.12745030
58IKBKB1.10572365
59CLK11.09946355
60LYN1.07015342
61PASK1.05343492
62PTK2B1.03955912
63MAP3K141.03462632
64PIM11.03373265
65CAMKK21.03343453
66DYRK31.02196348
67DAPK11.01159187
68FGFR21.01002670
69STK100.98711749
70LRRK20.98438854
71JAK10.98276452
72RPS6KB20.97315791
73MAP3K40.93108185
74MAP2K60.92285640
75LCK0.88442627
76FES0.88102178
77MAP3K60.87089427
78TAOK30.86495848
79ERN10.86378561
80PRKCQ0.86376062
81CDK80.84860131
82PNCK0.84128012
83ITK0.82448158
84MAP3K130.80847186
85HCK0.78369044
86BMPR20.77292211
87TIE10.75767327
88ATR0.74979995
89MAP3K110.74707087
90GRK60.74259296
91HIPK20.73958616
92PRKCE0.73067005
93EIF2AK30.70333887
94DYRK20.69069062
95STK390.66952016
96PAK30.65769331
97STK110.65547839
98MYLK0.64742615
99PIK3CA0.62984508
100MELK0.60506860
101JAK20.59960264
102TSSK60.59614261
103MAPK40.58236295
104PKN20.58187921
105SIK30.57542197
106CDK40.55227686
107FGFR30.54838825
108NLK0.54127791
109MAP2K20.53697032
110ABL10.53316249
111NEK20.53202136
112MAP3K50.53139313
113BMPR1B0.52318118
114MARK30.51261139
115MAPK70.51159878
116PRKCG0.49814731
117BUB10.49740744
118BCKDK0.49160293
119TLK10.48684048
120MAP2K70.48501763
121MAPKAPK30.48347533
122PRKD20.46993343
123TRPM70.46983463
124PIK3CG0.46891299
125MAP3K70.46846299
126PRKG20.45714775
127MAP2K10.44970011
128CHUK0.44488866
129RPS6KA50.44444576
130STK30.43986250
131STK40.43836851
132PRKCH0.43635823
133PAK40.42777980
134WNK10.40793225
135PLK20.39628732
136IRAK30.39401490
137CDK70.39365558
138CSK0.39002035
139RPS6KA60.38751033
140RAF10.37315024
141STK38L0.37164281
142IGF1R0.36376157
143ADRBK20.36098205
144YES10.35364349
145MKNK20.34535686
146EIF2AK20.34275272
147MST40.32346096
148PRKAA20.32232459
149SIK20.31961101
150AURKB0.28604080

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.93595401
2Ribosome_Homo sapiens_hsa030103.39778044
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.78630433
4Mismatch repair_Homo sapiens_hsa034302.75036439
5Linoleic acid metabolism_Homo sapiens_hsa005912.71864595
6Primary immunodeficiency_Homo sapiens_hsa053402.64663646
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56050499
8Base excision repair_Homo sapiens_hsa034102.45395242
9Leishmaniasis_Homo sapiens_hsa051402.19945955
10Caffeine metabolism_Homo sapiens_hsa002322.13933231
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07108992
12Antigen processing and presentation_Homo sapiens_hsa046122.05578193
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01835017
14Measles_Homo sapiens_hsa051621.94418779
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.92709312
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86902556
17Nitrogen metabolism_Homo sapiens_hsa009101.86355073
18Homologous recombination_Homo sapiens_hsa034401.86350054
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.82920198
20Hematopoietic cell lineage_Homo sapiens_hsa046401.80310829
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.78236685
22Herpes simplex infection_Homo sapiens_hsa051681.77946157
23Phototransduction_Homo sapiens_hsa047441.77695792
24Pyrimidine metabolism_Homo sapiens_hsa002401.76601585
25Selenocompound metabolism_Homo sapiens_hsa004501.72720678
26Nucleotide excision repair_Homo sapiens_hsa034201.70289407
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69337750
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68291586
29B cell receptor signaling pathway_Homo sapiens_hsa046621.67423421
30Ether lipid metabolism_Homo sapiens_hsa005651.65317417
31Proteasome_Homo sapiens_hsa030501.53766979
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52113018
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47785676
34Staphylococcus aureus infection_Homo sapiens_hsa051501.47229978
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46196219
36Chemical carcinogenesis_Homo sapiens_hsa052041.46109521
37Non-homologous end-joining_Homo sapiens_hsa034501.43964701
38RNA polymerase_Homo sapiens_hsa030201.42386932
39Tryptophan metabolism_Homo sapiens_hsa003801.41475564
40Spliceosome_Homo sapiens_hsa030401.41148060
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40614510
42Legionellosis_Homo sapiens_hsa051341.39156292
43Shigellosis_Homo sapiens_hsa051311.37940550
44Protein export_Homo sapiens_hsa030601.37102727
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.36353113
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34512785
47Osteoclast differentiation_Homo sapiens_hsa043801.34139027
48Pertussis_Homo sapiens_hsa051331.33552611
49Arachidonic acid metabolism_Homo sapiens_hsa005901.32302715
50Butanoate metabolism_Homo sapiens_hsa006501.31798038
51Allograft rejection_Homo sapiens_hsa053301.31587094
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22646388
53Influenza A_Homo sapiens_hsa051641.21210194
54N-Glycan biosynthesis_Homo sapiens_hsa005101.20898891
55Cell cycle_Homo sapiens_hsa041101.19546893
56RNA degradation_Homo sapiens_hsa030181.18092225
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17255292
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16565749
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13482521
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13238992
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12956994
62Other glycan degradation_Homo sapiens_hsa005111.12616652
63Fanconi anemia pathway_Homo sapiens_hsa034601.12237249
64Hepatitis B_Homo sapiens_hsa051611.11036335
65Platelet activation_Homo sapiens_hsa046111.08571403
66Acute myeloid leukemia_Homo sapiens_hsa052211.07147808
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05562526
68Primary bile acid biosynthesis_Homo sapiens_hsa001201.05517108
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04078862
70Oxidative phosphorylation_Homo sapiens_hsa001901.03303006
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02005349
72Dorso-ventral axis formation_Homo sapiens_hsa043201.01680545
73Toxoplasmosis_Homo sapiens_hsa051451.00759112
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99656301
75T cell receptor signaling pathway_Homo sapiens_hsa046600.99200684
76ABC transporters_Homo sapiens_hsa020100.98255178
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97806662
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96213973
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.95928874
80Tuberculosis_Homo sapiens_hsa051520.95707774
81Apoptosis_Homo sapiens_hsa042100.94830263
82Malaria_Homo sapiens_hsa051440.91740651
83Epstein-Barr virus infection_Homo sapiens_hsa051690.90629051
84Purine metabolism_Homo sapiens_hsa002300.90282165
85Type I diabetes mellitus_Homo sapiens_hsa049400.89623746
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87810626
87Asthma_Homo sapiens_hsa053100.87537854
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86476187
89TNF signaling pathway_Homo sapiens_hsa046680.84453694
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83655307
91RNA transport_Homo sapiens_hsa030130.82259451
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81902909
93Retinol metabolism_Homo sapiens_hsa008300.80354567
94Salmonella infection_Homo sapiens_hsa051320.79727591
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79689146
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78906701
97p53 signaling pathway_Homo sapiens_hsa041150.78873360
98Ovarian steroidogenesis_Homo sapiens_hsa049130.77821077
99Morphine addiction_Homo sapiens_hsa050320.77130578
100Thyroid cancer_Homo sapiens_hsa052160.76837790
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76105004
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74819261
103Histidine metabolism_Homo sapiens_hsa003400.73867323
104Peroxisome_Homo sapiens_hsa041460.72926771
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71481470
106Chemokine signaling pathway_Homo sapiens_hsa040620.69713652
107Graft-versus-host disease_Homo sapiens_hsa053320.66363197
108Viral carcinogenesis_Homo sapiens_hsa052030.65713477
109Basal transcription factors_Homo sapiens_hsa030220.65602189
110Hepatitis C_Homo sapiens_hsa051600.65393963
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65160106
112Prolactin signaling pathway_Homo sapiens_hsa049170.64211731
113Pentose phosphate pathway_Homo sapiens_hsa000300.62997213
114Autoimmune thyroid disease_Homo sapiens_hsa053200.62778185
115Chronic myeloid leukemia_Homo sapiens_hsa052200.60118689
116Serotonergic synapse_Homo sapiens_hsa047260.60041236
117Regulation of autophagy_Homo sapiens_hsa041400.60031926
118Olfactory transduction_Homo sapiens_hsa047400.59638168
119HTLV-I infection_Homo sapiens_hsa051660.55222690
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54510802
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.54459304
122Sulfur relay system_Homo sapiens_hsa041220.54413731
123African trypanosomiasis_Homo sapiens_hsa051430.53657862
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.53087870
125Glycerolipid metabolism_Homo sapiens_hsa005610.52655064
126Taste transduction_Homo sapiens_hsa047420.51482189
127Parkinsons disease_Homo sapiens_hsa050120.50510774
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.47986487
129One carbon pool by folate_Homo sapiens_hsa006700.47757340
130Viral myocarditis_Homo sapiens_hsa054160.44747517
131Sulfur metabolism_Homo sapiens_hsa009200.44536846
132Rheumatoid arthritis_Homo sapiens_hsa053230.44517943
133Galactose metabolism_Homo sapiens_hsa000520.43567641
134Systemic lupus erythematosus_Homo sapiens_hsa053220.43024586
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40713494
136Nicotine addiction_Homo sapiens_hsa050330.39718012
137Circadian rhythm_Homo sapiens_hsa047100.39235070
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38505766
139Calcium signaling pathway_Homo sapiens_hsa040200.37758560
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37740171
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.37681397
142Alzheimers disease_Homo sapiens_hsa050100.37521128
143Mineral absorption_Homo sapiens_hsa049780.37240139
144Type II diabetes mellitus_Homo sapiens_hsa049300.36559485
145Huntingtons disease_Homo sapiens_hsa050160.35981796
146Folate biosynthesis_Homo sapiens_hsa007900.34614831
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33246132
148Non-small cell lung cancer_Homo sapiens_hsa052230.33076574
149VEGF signaling pathway_Homo sapiens_hsa043700.32665198
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25629606
151Pancreatic cancer_Homo sapiens_hsa052120.24920566

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