RBM45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.23967105
2viral transcription (GO:0019083)5.07535369
3ribosomal small subunit biogenesis (GO:0042274)5.00043615
4ribosomal small subunit assembly (GO:0000028)4.94472082
5translational termination (GO:0006415)4.80369889
6facial nerve structural organization (GO:0021612)4.64514082
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45137452
8cotranslational protein targeting to membrane (GO:0006613)4.39033645
9protein targeting to ER (GO:0045047)4.35640255
10chromatin remodeling at centromere (GO:0031055)4.22555817
11postsynaptic membrane organization (GO:0001941)4.18154668
12CENP-A containing nucleosome assembly (GO:0034080)4.14545323
13lymphoid progenitor cell differentiation (GO:0002320)4.14402387
14protein localization to endoplasmic reticulum (GO:0070972)4.12888558
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.12363043
16respiratory chain complex IV assembly (GO:0008535)4.11973417
17DNA double-strand break processing (GO:0000729)4.11805015
18cullin deneddylation (GO:0010388)4.04461883
19negative regulation of transcription by competitive promoter binding (GO:0010944)4.04346688
20telomere maintenance via semi-conservative replication (GO:0032201)4.00009888
21presynaptic membrane assembly (GO:0097105)3.99835179
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.99636499
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.99636499
24protein deneddylation (GO:0000338)3.95512698
25regulation of pigment cell differentiation (GO:0050932)3.89935457
26synapsis (GO:0007129)3.88796278
27translational elongation (GO:0006414)3.80745566
28mannosylation (GO:0097502)3.79958727
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72163879
30viral life cycle (GO:0019058)3.69095998
31protein heterotetramerization (GO:0051290)3.67172497
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66161631
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66066797
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66066797
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66066797
36histone exchange (GO:0043486)3.65908328
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.63747944
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61843306
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60863360
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60863360
41maturation of SSU-rRNA (GO:0030490)3.60120093
42regulation of cellular amino acid metabolic process (GO:0006521)3.56746314
43cranial nerve morphogenesis (GO:0021602)3.54776306
44DNA catabolic process, exonucleolytic (GO:0000738)3.53996057
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.53522246
46cellular protein complex disassembly (GO:0043624)3.52466347
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.50665074
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50665074
49protein K6-linked ubiquitination (GO:0085020)3.49585789
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.49500419
51positive regulation of cellular amine metabolic process (GO:0033240)3.49475102
52ribosomal large subunit biogenesis (GO:0042273)3.47803106
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.47728641
54branched-chain amino acid catabolic process (GO:0009083)3.46936695
55GPI anchor biosynthetic process (GO:0006506)3.43431816
56mesonephros development (GO:0001823)3.42673099
57prenylation (GO:0097354)3.42356010
58protein prenylation (GO:0018342)3.42356010
59regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.41752685
60protein complex biogenesis (GO:0070271)3.38834876
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36534783
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36123609
63negative regulation of ligase activity (GO:0051352)3.36123609
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35649875
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.35649875
66NADH dehydrogenase complex assembly (GO:0010257)3.35649875
67negative regulation of myotube differentiation (GO:0010832)3.35358583
68recombinational repair (GO:0000725)3.34917157
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33510970
70cranial nerve structural organization (GO:0021604)3.32695095
71cytochrome complex assembly (GO:0017004)3.32352892
72nucleobase biosynthetic process (GO:0046112)3.31444390
73double-strand break repair via homologous recombination (GO:0000724)3.30791597
74telomere maintenance via recombination (GO:0000722)3.30598503
75nephron tubule formation (GO:0072079)3.29705618
76translational initiation (GO:0006413)3.27609751
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27569634
78mitochondrial respiratory chain complex assembly (GO:0033108)3.27502275
79organelle disassembly (GO:1903008)3.25662955
80purine nucleobase biosynthetic process (GO:0009113)3.24049645
81C-terminal protein lipidation (GO:0006501)3.23735847
82endothelium development (GO:0003158)3.23241223
83proteasome assembly (GO:0043248)3.23182899
84mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.22585719
85DNA ligation (GO:0006266)3.21965822
86replication fork processing (GO:0031297)3.21714557
87developmental pigmentation (GO:0048066)3.19976008
88presynaptic membrane organization (GO:0097090)3.19594857
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18569939
90regulation of mitotic spindle checkpoint (GO:1903504)3.18569939
91resolution of meiotic recombination intermediates (GO:0000712)3.18314254
92protein neddylation (GO:0045116)3.18058395
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17584731
94response to folic acid (GO:0051593)3.16229593
95adenosine metabolic process (GO:0046085)3.15949868
96double-strand break repair via nonhomologous end joining (GO:0006303)3.14176774
97non-recombinational repair (GO:0000726)3.14176774
98DNA damage response, detection of DNA damage (GO:0042769)3.12420642
99negative regulation of metanephros development (GO:0072217)3.12159484
100GDP-mannose metabolic process (GO:0019673)3.11016909
101pattern specification involved in kidney development (GO:0061004)3.10383511
102DNA replication initiation (GO:0006270)3.09737678
103postreplication repair (GO:0006301)3.09580020
104kinetochore assembly (GO:0051382)3.08751217
105amino sugar catabolic process (GO:0046348)3.06756872
106kinetochore organization (GO:0051383)3.05363052
107DNA strand elongation involved in DNA replication (GO:0006271)3.04451293
108protein complex disassembly (GO:0043241)3.02789947
109negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.02719309
110DNA replication checkpoint (GO:0000076)3.02705532
111regulation of mitochondrial translation (GO:0070129)3.00752223
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00749832
113platelet dense granule organization (GO:0060155)3.00112943
114DNA replication-independent nucleosome assembly (GO:0006336)2.99382174
115DNA replication-independent nucleosome organization (GO:0034724)2.99382174
116tRNA metabolic process (GO:0006399)2.96283994
117viral genome replication (GO:0019079)2.96263830
118dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.96056288
119GMP metabolic process (GO:0046037)2.95514380
120regulation of apoptotic process involved in morphogenesis (GO:1902337)2.95123590
121tRNA processing (GO:0008033)2.94588304
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93419739
123DNA strand elongation (GO:0022616)2.92947917
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92008258
125positive regulation of ligase activity (GO:0051351)2.91906812
126negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.89523425
127metallo-sulfur cluster assembly (GO:0031163)2.87321542
128iron-sulfur cluster assembly (GO:0016226)2.87321542
129macromolecular complex disassembly (GO:0032984)2.82619237
130sympathetic nervous system development (GO:0048485)2.82571188
131histone mRNA metabolic process (GO:0008334)2.81712071
132generation of neurons (GO:0048699)2.81383564
133GPI anchor metabolic process (GO:0006505)2.80721613
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80439745
135peptidyl-threonine dephosphorylation (GO:0035970)2.80141489
136ribonucleoprotein complex disassembly (GO:0032988)2.80093799
137attachment of spindle microtubules to kinetochore (GO:0008608)2.80045910
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79758136
139mitotic recombination (GO:0006312)2.79470495
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79090052
141tRNA aminoacylation (GO:0043039)2.78725222
142amino acid activation (GO:0043038)2.78725222
143histone H2A acetylation (GO:0043968)2.76998549
144androgen biosynthetic process (GO:0006702)2.76601103
145double-strand break repair (GO:0006302)2.75970124
146DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75757908
147N-acetylneuraminate metabolic process (GO:0006054)2.75096109
148urogenital system development (GO:0001655)2.74241131
149deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73894582
150deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73404246
151positive regulation of cell cycle arrest (GO:0071158)2.73140008
152peptidyl-histidine modification (GO:0018202)2.72672775
153translation (GO:0006412)2.72222556
154mature B cell differentiation (GO:0002335)2.71453182
155response to interferon-beta (GO:0035456)2.71443176
156signal peptide processing (GO:0006465)2.70329321
157regulation of ubiquitin-protein transferase activity (GO:0051438)2.70210012
158mitotic G2/M transition checkpoint (GO:0044818)2.69771445
159water-soluble vitamin biosynthetic process (GO:0042364)2.69229835
160telomere maintenance via telomere lengthening (GO:0010833)2.69069529
161tRNA methylation (GO:0030488)2.67937123
162regulation of glucokinase activity (GO:0033131)2.67212000
163regulation of hexokinase activity (GO:1903299)2.67212000
164C-terminal protein amino acid modification (GO:0018410)2.66628312
165mesenchymal to epithelial transition (GO:0060231)2.66213166
166DNA replication-dependent nucleosome assembly (GO:0006335)2.65968636
167DNA replication-dependent nucleosome organization (GO:0034723)2.65968636
168regulation of double-strand break repair via homologous recombination (GO:0010569)2.65194735
169omega-hydroxylase P450 pathway (GO:0097267)2.63215704
170protein targeting to membrane (GO:0006612)2.62516312
171fucose catabolic process (GO:0019317)2.60490279
172L-fucose metabolic process (GO:0042354)2.60490279
173L-fucose catabolic process (GO:0042355)2.60490279
174pseudouridine synthesis (GO:0001522)2.58524911
175centriole assembly (GO:0098534)2.58160975
176regulation of mesenchymal cell apoptotic process (GO:2001053)2.57518123
177transcription elongation from RNA polymerase III promoter (GO:0006385)2.54966880
178termination of RNA polymerase III transcription (GO:0006386)2.54966880
179thyroid gland development (GO:0030878)2.53912425
180GTP biosynthetic process (GO:0006183)2.53865660
181nuclear-transcribed mRNA catabolic process (GO:0000956)2.52688914
182ribonucleoprotein complex biogenesis (GO:0022613)2.51642124
183phospholipid scrambling (GO:0017121)2.51601425
184neuronal action potential propagation (GO:0019227)2.51595095
185mature B cell differentiation involved in immune response (GO:0002313)2.50706473
186centriole replication (GO:0007099)2.48794514
187regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.47831502
188mRNA catabolic process (GO:0006402)2.46152903
189exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45736365
190mast cell activation (GO:0045576)2.37801572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.74792036
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.26668780
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.33541189
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16075458
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15116637
6E2F7_22180533_ChIP-Seq_HELA_Human2.94736029
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82080872
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.55021526
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48077076
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45884414
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36780367
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36275619
13ZNF274_21170338_ChIP-Seq_K562_Hela2.33969530
14EWS_26573619_Chip-Seq_HEK293_Human2.24241624
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.20514702
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.15401291
17SCL_19346495_ChIP-Seq_HPC-7_Human2.14664892
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13677985
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10479552
20PADI4_21655091_ChIP-ChIP_MCF-7_Human2.08591205
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05387217
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04791337
23FUS_26573619_Chip-Seq_HEK293_Human1.98422413
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97286225
25IGF1R_20145208_ChIP-Seq_DFB_Human1.96344282
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95384162
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.89886446
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89460406
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.89102279
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87794129
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87038490
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80859585
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80710202
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79485909
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.77563874
36IRF1_19129219_ChIP-ChIP_H3396_Human1.74055616
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.70250799
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65965205
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63302731
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62889511
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61663861
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61532217
43VDR_22108803_ChIP-Seq_LS180_Human1.58331993
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52684580
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52487116
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51485020
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50830746
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50495767
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48672975
50GABP_19822575_ChIP-Seq_HepG2_Human1.48497973
51* VDR_23849224_ChIP-Seq_CD4+_Human1.46424734
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.45945156
53P300_19829295_ChIP-Seq_ESCs_Human1.45469581
54SPI1_23547873_ChIP-Seq_NB4_Human1.45134088
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42250241
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42137796
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.42131341
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41334041
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41287523
60GBX2_23144817_ChIP-Seq_PC3_Human1.40606602
61ELK1_19687146_ChIP-ChIP_HELA_Human1.38835592
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36771849
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36476107
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.35394486
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35126096
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.31496753
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30875282
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30161058
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29130012
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28990534
71FOXP3_21729870_ChIP-Seq_TREG_Human1.28281142
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.27866570
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.27629957
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26801610
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26435284
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26164471
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.25444477
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25381606
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25184418
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25101895
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.24164203
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22227480
83MYC_18940864_ChIP-ChIP_HL60_Human1.21746056
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21549390
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20406077
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19622297
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.17833539
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17349011
89TAF15_26573619_Chip-Seq_HEK293_Human1.17137803
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15966368
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.15405132
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12242510
93TTF2_22483619_ChIP-Seq_HELA_Human1.11683753
94RNF2_27304074_Chip-Seq_NSC_Mouse1.11395068
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10127580
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09142715
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.09011607
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08324503
99ER_23166858_ChIP-Seq_MCF-7_Human1.07447417
100CBP_20019798_ChIP-Seq_JUKART_Human1.07360124
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07360124
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07205893
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06331202
104TP53_22573176_ChIP-Seq_HFKS_Human1.05288903
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04940325
106* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03966984
107MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03520675
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03102108
109AR_21909140_ChIP-Seq_LNCAP_Human1.03048279
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01857909
111ELK1_22589737_ChIP-Seq_MCF10A_Human1.01575497
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01311385
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00310395
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99780773
115LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99488183
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99487053
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98722912
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.98378066
119VDR_24763502_ChIP-Seq_THP-1_Human0.98366842
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97581109
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96404126
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96332745
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96288505
124* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95697861
125P300_18555785_Chip-Seq_ESCs_Mouse0.95557497
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.95316708
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95237210
128TFEB_21752829_ChIP-Seq_HELA_Human0.94572823
129P53_22387025_ChIP-Seq_ESCs_Mouse0.94417218
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93619194
131KDM5A_27292631_Chip-Seq_BREAST_Human0.93156703
132FOXM1_23109430_ChIP-Seq_U2OS_Human0.93108824
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.92979270
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92068993
135FOXA1_25329375_ChIP-Seq_VCAP_Human0.92068993
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.91577905
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90908718
138* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90360383
139TAL1_26923725_Chip-Seq_HPCs_Mouse0.90208357
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89945322
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89914498
142SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89400451
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89045531
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88134739
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87132285
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87052354
147JUN_21703547_ChIP-Seq_K562_Human0.86868112
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86774353
149MYB_26560356_Chip-Seq_TH2_Human0.85734496
150DCP1A_22483619_ChIP-Seq_HELA_Human0.83341233
151GATA3_21867929_ChIP-Seq_CD8_Mouse0.83081901
152OCT4_18555785_Chip-Seq_ESCs_Mouse0.83022235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.62019737
2MP0003136_yellow_coat_color4.68999662
3MP0008877_abnormal_DNA_methylation4.55201966
4MP0003806_abnormal_nucleotide_metabolis4.44265615
5MP0005409_darkened_coat_color4.40666943
6MP0001188_hyperpigmentation4.17621820
7MP0005174_abnormal_tail_pigmentation3.80319318
8MP0006292_abnormal_olfactory_placode3.64267906
9MP0006054_spinal_hemorrhage3.35666762
10MP0004381_abnormal_hair_follicle3.34851974
11MP0000015_abnormal_ear_pigmentation3.29407625
12MP0009697_abnormal_copulation3.09514815
13MP0001529_abnormal_vocalization2.89779334
14MP0003724_increased_susceptibility_to2.78655071
15MP0008057_abnormal_DNA_replication2.74358651
16MP0003787_abnormal_imprinting2.57610785
17MP0004957_abnormal_blastocyst_morpholog2.50499293
18MP0005075_abnormal_melanosome_morpholog2.36496430
19MP0003111_abnormal_nucleus_morphology2.35937934
20MP0003880_abnormal_central_pattern2.30301524
21MP0000372_irregular_coat_pigmentation2.29535346
22MP0000569_abnormal_digit_pigmentation2.23736737
23MP0001986_abnormal_taste_sensitivity2.21981562
24MP0002095_abnormal_skin_pigmentation2.17472611
25MP0006072_abnormal_retinal_apoptosis2.10545008
26MP0003121_genomic_imprinting2.09131309
27MP0008260_abnormal_autophagy1.99568553
28MP0003186_abnormal_redox_activity1.92124514
29MP0001835_abnormal_antigen_presentation1.80171263
30MP0002102_abnormal_ear_morphology1.79844810
31MP0009785_altered_susceptibility_to1.71901784
32MP0000681_abnormal_thyroid_gland1.69806700
33MP0002148_abnormal_hypersensitivity_rea1.68914245
34MP0000490_abnormal_crypts_of1.68617456
35MP0005671_abnormal_response_to1.67059765
36MP0002876_abnormal_thyroid_physiology1.62011374
37MP0003763_abnormal_thymus_physiology1.57052625
38MP0000049_abnormal_middle_ear1.56342748
39MP0000465_gastrointestinal_hemorrhage1.55601163
40MP0008932_abnormal_embryonic_tissue1.55201241
41MP0006036_abnormal_mitochondrial_physio1.53940337
42MP0003077_abnormal_cell_cycle1.53851948
43MP0006035_abnormal_mitochondrial_morpho1.53705719
44MP0002177_abnormal_outer_ear1.50525330
45MP0003938_abnormal_ear_development1.48775746
46MP0009333_abnormal_splenocyte_physiolog1.48081901
47MP0005253_abnormal_eye_physiology1.44755547
48MP0003303_peritoneal_inflammation1.44697898
49MP0005025_abnormal_response_to1.41201343
50MP0001293_anophthalmia1.40799615
51MP0002090_abnormal_vision1.40219352
52MP0003567_abnormal_fetal_cardiomyocyte1.40134986
53MP0005000_abnormal_immune_tolerance1.39298715
54MP0000566_synostosis1.37353043
55MP0003315_abnormal_perineum_morphology1.36667429
56MP0001764_abnormal_homeostasis1.33821491
57MP0002277_abnormal_respiratory_mucosa1.32598825
58MP0010234_abnormal_vibrissa_follicle1.30876211
59MP0005646_abnormal_pituitary_gland1.30423207
60MP0002751_abnormal_autonomic_nervous1.29562444
61MP0001853_heart_inflammation1.27887715
62MP0002837_dystrophic_cardiac_calcinosis1.27784368
63MP0003646_muscle_fatigue1.23309731
64MP0003252_abnormal_bile_duct1.23173656
65MP0000613_abnormal_salivary_gland1.22659977
66MP0000685_abnormal_immune_system1.21699441
67MP0002009_preneoplasia1.20409805
68MP0008058_abnormal_DNA_repair1.19709712
69MP0003436_decreased_susceptibility_to1.18564951
70MP0002420_abnormal_adaptive_immunity1.17986051
71MP0002723_abnormal_immune_serum1.17154262
72MP0002210_abnormal_sex_determination1.17147140
73MP0001819_abnormal_immune_cell1.16239607
74MP0002396_abnormal_hematopoietic_system1.15448067
75MP0002419_abnormal_innate_immunity1.12940822
76MP0002249_abnormal_larynx_morphology1.12614092
77MP0005171_absent_coat_pigmentation1.12255409
78MP0002938_white_spotting1.11564699
79MP0001800_abnormal_humoral_immune1.11035206
80MP0002452_abnormal_antigen_presenting1.09681340
81MP0005551_abnormal_eye_electrophysiolog1.08435133
82MP0001929_abnormal_gametogenesis1.06973939
83MP0000631_abnormal_neuroendocrine_gland1.06204954
84MP0002638_abnormal_pupillary_reflex1.05355229
85MP0005367_renal/urinary_system_phenotyp1.03107137
86MP0000516_abnormal_urinary_system1.03107137
87MP0003385_abnormal_body_wall1.02325135
88MP0003786_premature_aging1.01130715
89MP0003937_abnormal_limbs/digits/tail_de0.98035672
90MP0005408_hypopigmentation0.97921079
91MP0000427_abnormal_hair_cycle0.96917495
92MP0000647_abnormal_sebaceous_gland0.96638720
93MP0002398_abnormal_bone_marrow0.96520150
94MP0003879_abnormal_hair_cell0.96157935
95MP0002132_abnormal_respiratory_system0.95988333
96MP0005395_other_phenotype0.95094766
97MP0000358_abnormal_cell_content/0.93030909
98MP0000716_abnormal_immune_system0.92940521
99MP0001919_abnormal_reproductive_system0.90503735
100MP0003693_abnormal_embryo_hatching0.90381858
101MP0002006_tumorigenesis0.90056639
102MP0000653_abnormal_sex_gland0.89977495
103MP0002160_abnormal_reproductive_system0.89806547
104MP0001119_abnormal_female_reproductive0.89357805
105MP0002166_altered_tumor_susceptibility0.89016501
106MP0001873_stomach_inflammation0.88456727
107MP0000026_abnormal_inner_ear0.87342644
108MP0001145_abnormal_male_reproductive0.86942143
109MP0001324_abnormal_eye_pigmentation0.86773125
110MP0003718_maternal_effect0.86689583
111MP0002127_abnormal_cardiovascular_syste0.85505182
112MP0001790_abnormal_immune_system0.84620222
113MP0005387_immune_system_phenotype0.84620222
114MP0001984_abnormal_olfaction0.84427408
115MP0002233_abnormal_nose_morphology0.83786794
116MP0000689_abnormal_spleen_morphology0.82900263
117MP0001663_abnormal_digestive_system0.82776503
118MP0002933_joint_inflammation0.80752389
119MP0010155_abnormal_intestine_physiology0.80696887
120MP0001697_abnormal_embryo_size0.80352671
121MP0005266_abnormal_metabolism0.80225975
122MP0004142_abnormal_muscle_tone0.79880424
123MP0003866_abnormal_defecation0.79016330
124MP0008995_early_reproductive_senescence0.78802250
125MP0002075_abnormal_coat/hair_pigmentati0.77835059
126MP0004742_abnormal_vestibular_system0.77327843
127MP0008789_abnormal_olfactory_epithelium0.76513270
128MP0010307_abnormal_tumor_latency0.76451356
129MP0005499_abnormal_olfactory_system0.76130841
130MP0005394_taste/olfaction_phenotype0.76130841
131MP0000678_abnormal_parathyroid_gland0.75790532
132MP0001186_pigmentation_phenotype0.75781407
133MP0002429_abnormal_blood_cell0.74798549
134MP0002722_abnormal_immune_system0.74790125
135MP0002405_respiratory_system_inflammati0.73903385
136MP0006276_abnormal_autonomic_nervous0.73470904
137MP0002019_abnormal_tumor_incidence0.72056241
138MP0004215_abnormal_myocardial_fiber0.71577272
139MP0005379_endocrine/exocrine_gland_phen0.71072857
140MP0005391_vision/eye_phenotype0.70482810
141MP0001963_abnormal_hearing_physiology0.69003773
142MP0003828_pulmonary_edema0.67692783
143MP0005389_reproductive_system_phenotype0.67659277
144MP0003122_maternal_imprinting0.67523297
145MP0003011_delayed_dark_adaptation0.67101518
146MP0005410_abnormal_fertilization0.65953163
147MP0003698_abnormal_male_reproductive0.65722341
148MP0005248_abnormal_Harderian_gland0.65529285
149MP0004134_abnormal_chest_morphology0.65334341
150MP0001905_abnormal_dopamine_level0.65195977
151MP0000858_altered_metastatic_potential0.65176280
152MP0003941_abnormal_skin_development0.64274783
153MP0002163_abnormal_gland_morphology0.62962338
154MP0005464_abnormal_platelet_physiology0.62902192
155MP0010678_abnormal_skin_adnexa0.62782931
156MP0001348_abnormal_lacrimal_gland0.62695487
157MP0004147_increased_porphyrin_level0.61878428
158MP0000313_abnormal_cell_death0.61693466
159MP0008875_abnormal_xenobiotic_pharmacok0.60871053
160MP0010094_abnormal_chromosome_stability0.60515024
161MP0008007_abnormal_cellular_replicative0.59454640
162MP0008873_increased_physiological_sensi0.59423024
163MP0005084_abnormal_gallbladder_morpholo0.59038474
164MP0009765_abnormal_xenobiotic_induced0.58970178
165MP0001881_abnormal_mammary_gland0.56522398
166MP0003950_abnormal_plasma_membrane0.54909318
167MP0005165_increased_susceptibility_to0.54386948

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)6.72966635
2Reduced antithrombin III activity (HP:0001976)6.67096815
3Abnormal protein glycosylation (HP:0012346)4.71469199
4Abnormal glycosylation (HP:0012345)4.71469199
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.71469199
6Abnormal protein N-linked glycosylation (HP:0012347)4.71469199
7Abnormality of cells of the erythroid lineage (HP:0012130)4.36343896
8Abnormal number of erythroid precursors (HP:0012131)4.28212194
9Thyroid-stimulating hormone excess (HP:0002925)4.01993777
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.93588298
11Hypothermia (HP:0002045)3.85869002
12Acute necrotizing encephalopathy (HP:0006965)3.83839214
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56392289
14Progressive macrocephaly (HP:0004481)3.55756716
15Acute encephalopathy (HP:0006846)3.55516665
16Reticulocytopenia (HP:0001896)3.52038259
17Severe visual impairment (HP:0001141)3.45394486
18Increased CSF lactate (HP:0002490)3.44756212
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.41534168
20Abnormal mitochondria in muscle tissue (HP:0008316)3.41506858
21Abnormality of the axillary hair (HP:0100134)3.34278374
22Abnormality of secondary sexual hair (HP:0009888)3.34278374
23Increased hepatocellular lipid droplets (HP:0006565)3.33085046
24Abnormality of the labia minora (HP:0012880)3.31989013
25Nonprogressive disorder (HP:0003680)3.15988643
26Renal Fanconi syndrome (HP:0001994)3.04058630
27Methylmalonic acidemia (HP:0002912)3.02265341
28Attenuation of retinal blood vessels (HP:0007843)2.87292588
29Exertional dyspnea (HP:0002875)2.84116322
30Abnormal biliary tract physiology (HP:0012439)2.78013773
31Bile duct proliferation (HP:0001408)2.78013773
32Macrocytic anemia (HP:0001972)2.75675528
33Abnormal sex determination (HP:0012244)2.71721276
34Sex reversal (HP:0012245)2.71721276
35Cerebral edema (HP:0002181)2.68742640
36Molar tooth sign on MRI (HP:0002419)2.64720671
37Abnormality of midbrain morphology (HP:0002418)2.64720671
38Lipid accumulation in hepatocytes (HP:0006561)2.64461593
39Abnormality of magnesium homeostasis (HP:0004921)2.64189735
40Pallor (HP:0000980)2.61094332
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58962139
42Increased serum lactate (HP:0002151)2.58427196
43Abnormal rod and cone electroretinograms (HP:0008323)2.56442862
44Posterior subcapsular cataract (HP:0007787)2.54455227
453-Methylglutaconic aciduria (HP:0003535)2.53103353
46Medial flaring of the eyebrow (HP:0010747)2.52390421
47Colon cancer (HP:0003003)2.50969592
48Aplastic anemia (HP:0001915)2.50601329
49Obstructive lung disease (HP:0006536)2.49894387
50Chronic obstructive pulmonary disease (HP:0006510)2.49894387
51Elevated erythrocyte sedimentation rate (HP:0003565)2.48961785
52Neoplasm of the adrenal gland (HP:0100631)2.47214702
53Methylmalonic aciduria (HP:0012120)2.45616040
54Stomatitis (HP:0010280)2.44107790
55Increased serum pyruvate (HP:0003542)2.43331753
56Hepatocellular necrosis (HP:0001404)2.42497808
57Split foot (HP:0001839)2.41829610
58True hermaphroditism (HP:0010459)2.41792629
59Meningitis (HP:0001287)2.36178016
60Flat occiput (HP:0005469)2.33187803
61Type 2 muscle fiber atrophy (HP:0003554)2.32017474
62Nephronophthisis (HP:0000090)2.31374415
63Dry hair (HP:0011359)2.31244287
64Lactic acidosis (HP:0003128)2.30339507
65Bifid tongue (HP:0010297)2.28850824
66Abnormal spermatogenesis (HP:0008669)2.28702063
67Cortical visual impairment (HP:0100704)2.28256283
68Intestinal atresia (HP:0011100)2.26976066
69Azoospermia (HP:0000027)2.26563526
70Abnormality of glycolysis (HP:0004366)2.22645069
71Muscle fiber atrophy (HP:0100295)2.21575787
72Prolonged partial thromboplastin time (HP:0003645)2.15637421
73Abnormality of chromosome stability (HP:0003220)2.15203702
74B lymphocytopenia (HP:0010976)2.12852957
75Abnormality of methionine metabolism (HP:0010901)2.12778208
76Microvesicular hepatic steatosis (HP:0001414)2.10073732
77Increased intramyocellular lipid droplets (HP:0012240)2.09659112
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.08831595
79Microcytic anemia (HP:0001935)2.08806593
80Respiratory failure (HP:0002878)2.08664701
81Abnormality of the columella (HP:0009929)2.07945515
82Thrombocytosis (HP:0001894)2.07386822
83Abnormality of B cell number (HP:0010975)2.07333741
84Renal cortical cysts (HP:0000803)2.06859135
85Leukodystrophy (HP:0002415)2.06773283
86Neoplasm of the adrenal cortex (HP:0100641)2.06041739
87CNS demyelination (HP:0007305)2.04779573
88Thyroiditis (HP:0100646)2.04237137
89IgM deficiency (HP:0002850)2.03615152
90Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01922856
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.01666575
92Abnormality of the prostate (HP:0008775)2.01178042
93Petechiae (HP:0000967)2.00412301
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00237942
95Abnormality of the renal medulla (HP:0100957)2.00157950
96Abnormality of the ileum (HP:0001549)1.99659511
97Myositis (HP:0100614)1.98930873
98Respiratory difficulties (HP:0002880)1.98483477
99Mitochondrial inheritance (HP:0001427)1.96772331
100Abnormality of renal resorption (HP:0011038)1.96686279
101Median cleft lip (HP:0000161)1.96099773
102Pancreatic islet-cell hyperplasia (HP:0004510)1.95519361
103Ocular albinism (HP:0001107)1.93288158
104Parakeratosis (HP:0001036)1.92982996
105Patchy hypopigmentation of hair (HP:0011365)1.92470834
106Recurrent abscess formation (HP:0002722)1.92312215
107Abnormality of the preputium (HP:0100587)1.86812168
108Thoracic kyphosis (HP:0002942)1.85710259
109Congenital primary aphakia (HP:0007707)1.85321777
110Chromsome breakage (HP:0040012)1.84081038
111Pancreatic fibrosis (HP:0100732)1.83047978
112Hepatic necrosis (HP:0002605)1.82329975
113Pancreatic cysts (HP:0001737)1.81476339
114Aplasia/hypoplasia of the uterus (HP:0008684)1.81066555
115Abnormality of the renal cortex (HP:0011035)1.80467033
116Neoplasm of the peripheral nervous system (HP:0100007)1.80373919
117Severe combined immunodeficiency (HP:0004430)1.79690440
118Lethargy (HP:0001254)1.79332802
119Hypoplasia of the radius (HP:0002984)1.79230598
120Optic disc pallor (HP:0000543)1.79037185
121Abnormality of lateral ventricle (HP:0030047)1.77989602
122Rectal fistula (HP:0100590)1.77648581
123Rectovaginal fistula (HP:0000143)1.77648581
124Mediastinal lymphadenopathy (HP:0100721)1.76750288
125Progressive microcephaly (HP:0000253)1.76247808
126Abnormality of vitamin B metabolism (HP:0004340)1.76070566
127Anencephaly (HP:0002323)1.75888606
128Agammaglobulinemia (HP:0004432)1.75331377
129Capillary hemangiomas (HP:0005306)1.75190709
130Decreased central vision (HP:0007663)1.75167242
131Hypomagnesemia (HP:0002917)1.74722367
132Clubbing of toes (HP:0100760)1.74392878
133Pulmonary fibrosis (HP:0002206)1.73182127
134Genital tract atresia (HP:0001827)1.71045612
135Abnormality of the vitamin B12 metabolism (HP:0004341)1.69823168
136Male pseudohermaphroditism (HP:0000037)1.69173989
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.68989344
138Hypoplasia of the fovea (HP:0007750)1.68989344
139Abnormal lung lobation (HP:0002101)1.68453844
140Nephrogenic diabetes insipidus (HP:0009806)1.67890250
141Prolonged bleeding time (HP:0003010)1.66420955
142Sloping forehead (HP:0000340)1.66410959
143Progressive inability to walk (HP:0002505)1.66176464
144Absent septum pellucidum (HP:0001331)1.64844172
145Hyperglycinuria (HP:0003108)1.64721546
146White forelock (HP:0002211)1.64491814
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64105998
148Abnormality of the septum pellucidum (HP:0007375)1.63900635
149Volvulus (HP:0002580)1.63771988
150Iris hypopigmentation (HP:0007730)1.63705684
151Dicarboxylic aciduria (HP:0003215)1.63106765
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63106765
153Abnormality of the metopic suture (HP:0005556)1.62554282
154Lower limb hyperreflexia (HP:0002395)1.62486338
155Optic nerve hypoplasia (HP:0000609)1.61960043
156Adrenal hypoplasia (HP:0000835)1.61646943
157Abnormality of DNA repair (HP:0003254)1.61575961
158Short tibia (HP:0005736)1.61462246
159Hypoproteinemia (HP:0003075)1.61413146
160Triphalangeal thumb (HP:0001199)1.61387171
161Chronic otitis media (HP:0000389)1.60045828
162Pancytopenia (HP:0001876)1.60013611
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59777084
164Abnormality of alanine metabolism (HP:0010916)1.59777084
165Hyperalaninemia (HP:0003348)1.59777084
166Meckel diverticulum (HP:0002245)1.58562452
167Supernumerary spleens (HP:0009799)1.58117508
168Chronic mucocutaneous candidiasis (HP:0002728)1.57173218
169Recurrent cutaneous fungal infections (HP:0011370)1.57173218
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.57166190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.65147200
2EIF2AK34.43205832
3MKNK23.95826897
4MUSK3.88548594
5STK163.48579174
6CASK3.38421396
7NLK2.91360875
8TRIM282.83113619
9NME22.80528535
10MKNK12.69902831
11FRK2.60441597
12NEK12.52507078
13TLK12.30482049
14IRAK32.28708274
15IRAK42.23575104
16CAMKK22.22604531
17FES2.17613083
18CCNB12.14244426
19MAP4K21.95337260
20BLK1.85110323
21EIF2AK21.83709291
22TEC1.77229233
23PLK31.66847822
24CDK191.66298349
25VRK21.58451390
26SRPK11.44962191
27VRK11.40725963
28PINK11.40541915
29BRSK21.40015176
30TTK1.35802038
31ERBB31.34129739
32WNK31.34038287
33PIM21.33604934
34KIT1.33414354
35BCKDK1.30052267
36YES11.29915180
37WEE11.27798679
38TSSK61.21509258
39PLK21.12368438
40CLK11.11404911
41TXK1.10122341
42IRAK21.10014754
43TAF11.10013547
44PLK11.09968525
45STK38L1.09701456
46STK391.08990862
47RPS6KA41.07420483
48ADRBK21.06282415
49MST41.04934251
50CAMK11.02114561
51STK31.01374578
52PDK21.00758680
53MAP2K71.00053368
54PAK30.99527783
55IRAK10.99517347
56BTK0.98626177
57MAP3K40.97992016
58ATR0.97662978
59BCR0.97524782
60PNCK0.95153807
61DYRK30.94178754
62PRPF4B0.88920515
63CSNK1G20.85884464
64MAPK130.81462008
65MAP3K120.80887263
66IKBKB0.78139153
67SCYL20.77808575
68PRKD20.76044019
69LYN0.72453280
70DAPK10.71143766
71IKBKE0.69973440
72RIPK40.68563001
73MAP4K10.67492284
74BMPR1B0.66961347
75LATS10.66124886
76HIPK20.64183026
77CHEK20.64037279
78WNK40.63499101
79MAPKAPK50.63411256
80SYK0.63234146
81CDK70.61278449
82MAPKAPK30.58969840
83ACVR1B0.58685232
84CDK30.58487526
85GRK10.58266472
86BRD40.57821593
87CSNK1G10.57657405
88MINK10.57154114
89SIK30.56207021
90CSF1R0.55501080
91LCK0.53504603
92MAP3K140.53502463
93KDR0.52888301
94MAPK40.52307909
95ATM0.51787863
96PRKG20.51197087
97ZAK0.50897559
98RPS6KA50.50448779
99GRK70.50441145
100TNK20.50314304
101PASK0.45771869
102PBK0.45423967
103BUB10.44315994
104MAP3K50.44168259
105TGFBR10.43344067
106EIF2AK10.42227965
107CSK0.42224171
108MAPK150.41734641
109CSNK1G30.41281462
110FLT30.39919779
111CAMK2B0.39714294
112PIM10.38242336
113HCK0.38129919
114BMPR20.37467384
115ERBB40.37430941
116DYRK20.37114334
117UHMK10.36601079
118CSNK1A10.36559887
119FER0.35697772
120CDK140.34640896
121ALK0.34313237
122ZAP700.33698039
123DYRK1A0.33611104
124STK40.33602511
125EGFR0.33285060
126CSNK2A20.32223905
127CHEK10.32018798
128MATK0.31273294
129RAF10.30249871
130CSNK2A10.30071615
131PLK40.28907765
132PIK3CG0.28200000
133FGR0.27344296
134CSNK1A1L0.25875590
135NUAK10.24577041
136CDK80.24470752
137OXSR10.21384319
138TGFBR20.20571019
139TBK10.20340188
140CDC70.20045595
141CDK40.19262964
142AURKB0.19247448
143TIE10.19117413
144RPS6KB20.19085925
145ABL10.18991779
146PRKAA20.18407565
147CAMK40.17000068
148TAOK30.16262943
149PRKG10.15683309
150TYK20.15682400

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.65734531
2DNA replication_Homo sapiens_hsa030303.63187864
3Propanoate metabolism_Homo sapiens_hsa006402.94463148
4Protein export_Homo sapiens_hsa030602.66823090
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.64960978
6Homologous recombination_Homo sapiens_hsa034402.58708897
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39997572
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31325024
9Mismatch repair_Homo sapiens_hsa034302.30400878
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21765792
11Fanconi anemia pathway_Homo sapiens_hsa034602.15481907
12RNA polymerase_Homo sapiens_hsa030202.08042276
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05142917
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92047837
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90935559
16Other glycan degradation_Homo sapiens_hsa005111.80887110
17Spliceosome_Homo sapiens_hsa030401.79233662
18Pyrimidine metabolism_Homo sapiens_hsa002401.78907099
19Nucleotide excision repair_Homo sapiens_hsa034201.77271385
20Base excision repair_Homo sapiens_hsa034101.75073200
21Primary immunodeficiency_Homo sapiens_hsa053401.72550753
22N-Glycan biosynthesis_Homo sapiens_hsa005101.71192399
23Non-homologous end-joining_Homo sapiens_hsa034501.55094300
24Basal transcription factors_Homo sapiens_hsa030221.45399920
25Phototransduction_Homo sapiens_hsa047441.45352628
26Selenocompound metabolism_Homo sapiens_hsa004501.44558798
27Sulfur metabolism_Homo sapiens_hsa009201.41235873
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38460261
29Oxidative phosphorylation_Homo sapiens_hsa001901.36838259
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35929792
31Proteasome_Homo sapiens_hsa030501.33809038
32Pyruvate metabolism_Homo sapiens_hsa006201.33622902
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32868820
34Allograft rejection_Homo sapiens_hsa053301.28669103
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26228661
36Butanoate metabolism_Homo sapiens_hsa006501.25599605
37Purine metabolism_Homo sapiens_hsa002301.24253834
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.23825626
39Sphingolipid metabolism_Homo sapiens_hsa006001.22965154
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22753685
41Hematopoietic cell lineage_Homo sapiens_hsa046401.22085628
42Asthma_Homo sapiens_hsa053101.21733482
43Systemic lupus erythematosus_Homo sapiens_hsa053221.20220956
44Steroid biosynthesis_Homo sapiens_hsa001001.20017260
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18415769
46Thyroid cancer_Homo sapiens_hsa052161.17320285
47Fatty acid elongation_Homo sapiens_hsa000621.15855211
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12922822
49Arachidonic acid metabolism_Homo sapiens_hsa005901.09346509
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.07465221
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05723501
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05519497
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.04757786
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04344798
55Peroxisome_Homo sapiens_hsa041461.03818003
56Measles_Homo sapiens_hsa051621.01134352
57Autoimmune thyroid disease_Homo sapiens_hsa053201.00876603
58Graft-versus-host disease_Homo sapiens_hsa053320.99751778
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98932619
60Malaria_Homo sapiens_hsa051440.98529429
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96320867
62Glutathione metabolism_Homo sapiens_hsa004800.96221634
63RNA degradation_Homo sapiens_hsa030180.92151148
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91879468
65Herpes simplex infection_Homo sapiens_hsa051680.89712124
66p53 signaling pathway_Homo sapiens_hsa041150.89710149
67Sulfur relay system_Homo sapiens_hsa041220.86860306
68Parkinsons disease_Homo sapiens_hsa050120.85400493
69Leishmaniasis_Homo sapiens_hsa051400.83236770
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.80196711
71Collecting duct acid secretion_Homo sapiens_hsa049660.78507917
72Vitamin B6 metabolism_Homo sapiens_hsa007500.77525081
73Type I diabetes mellitus_Homo sapiens_hsa049400.76444848
74Ether lipid metabolism_Homo sapiens_hsa005650.73883560
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72883569
76mRNA surveillance pathway_Homo sapiens_hsa030150.72599977
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71340529
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71203367
79Alzheimers disease_Homo sapiens_hsa050100.70699231
80Huntingtons disease_Homo sapiens_hsa050160.70344803
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69934547
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68280467
83Oocyte meiosis_Homo sapiens_hsa041140.65267980
84Alcoholism_Homo sapiens_hsa050340.62370454
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61989979
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59076284
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58485300
88One carbon pool by folate_Homo sapiens_hsa006700.58174681
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.56683957
90Pertussis_Homo sapiens_hsa051330.54535531
91Tryptophan metabolism_Homo sapiens_hsa003800.54153306
92Cell cycle_Homo sapiens_hsa041100.53448574
93Acute myeloid leukemia_Homo sapiens_hsa052210.52714444
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51236711
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51011000
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49422228
97Antigen processing and presentation_Homo sapiens_hsa046120.49114515
98B cell receptor signaling pathway_Homo sapiens_hsa046620.48345607
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48010054
100Carbon metabolism_Homo sapiens_hsa012000.47261806
101Linoleic acid metabolism_Homo sapiens_hsa005910.46434250
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46398799
103Osteoclast differentiation_Homo sapiens_hsa043800.45888940
104Olfactory transduction_Homo sapiens_hsa047400.43908187
105Rheumatoid arthritis_Homo sapiens_hsa053230.43076243
106Renin-angiotensin system_Homo sapiens_hsa046140.42810595
107Folate biosynthesis_Homo sapiens_hsa007900.42411916
108RNA transport_Homo sapiens_hsa030130.41285506
109African trypanosomiasis_Homo sapiens_hsa051430.41228834
110Fatty acid metabolism_Homo sapiens_hsa012120.39480484
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.39306036
112Nicotine addiction_Homo sapiens_hsa050330.39239570
113Serotonergic synapse_Homo sapiens_hsa047260.38149055
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37792746
115Wnt signaling pathway_Homo sapiens_hsa043100.37586206
116Regulation of autophagy_Homo sapiens_hsa041400.37042190
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36974682
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35543771
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34606721
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33989784
121Fatty acid degradation_Homo sapiens_hsa000710.33595855
122Tuberculosis_Homo sapiens_hsa051520.33491937
123Epstein-Barr virus infection_Homo sapiens_hsa051690.33304597
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.32063849
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.31894800
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31408399
127T cell receptor signaling pathway_Homo sapiens_hsa046600.31290078
128Metabolic pathways_Homo sapiens_hsa011000.31233113
129Salmonella infection_Homo sapiens_hsa051320.30475418
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30312589
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30279522
132Taste transduction_Homo sapiens_hsa047420.29098958
133Basal cell carcinoma_Homo sapiens_hsa052170.28922983
134Influenza A_Homo sapiens_hsa051640.28609743
135Hepatitis B_Homo sapiens_hsa051610.28324662
136beta-Alanine metabolism_Homo sapiens_hsa004100.28127771
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28101657
138Nitrogen metabolism_Homo sapiens_hsa009100.26660406
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25206774
140Shigellosis_Homo sapiens_hsa051310.24242261
141Legionellosis_Homo sapiens_hsa051340.23913390
142Retinol metabolism_Homo sapiens_hsa008300.21854618

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