

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | hydrogen peroxide biosynthetic process (GO:0050665) | 4.21549393 |
| 2 | glucuronate metabolic process (GO:0019585) | 4.17297188 |
| 3 | uronic acid metabolic process (GO:0006063) | 4.17297188 |
| 4 | xenobiotic catabolic process (GO:0042178) | 3.93332483 |
| 5 | detection of molecule of bacterial origin (GO:0032490) | 3.92503325 |
| 6 | intestinal cholesterol absorption (GO:0030299) | 3.90160732 |
| 7 | cellular glucuronidation (GO:0052695) | 3.87729032 |
| 8 | phenylpropanoid metabolic process (GO:0009698) | 3.83495491 |
| 9 | macrophage activation involved in immune response (GO:0002281) | 3.82002369 |
| 10 | reactive oxygen species biosynthetic process (GO:1903409) | 3.71639543 |
| 11 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.56596809 |
| 12 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.56596809 |
| 13 | modulation by symbiont of host immune response (GO:0052553) | 3.56596809 |
| 14 | positive regulation by symbiont of host defense response (GO:0052509) | 3.56596809 |
| 15 | modulation by symbiont of host defense response (GO:0052031) | 3.56596809 |
| 16 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.56596809 |
| 17 | tryptophan catabolic process (GO:0006569) | 3.45893553 |
| 18 | indole-containing compound catabolic process (GO:0042436) | 3.45893553 |
| 19 | indolalkylamine catabolic process (GO:0046218) | 3.45893553 |
| 20 | tryptophan metabolic process (GO:0006568) | 3.45012304 |
| 21 | intestinal absorption (GO:0050892) | 3.44201422 |
| 22 | response to nitrosative stress (GO:0051409) | 3.42612077 |
| 23 | neutrophil activation involved in immune response (GO:0002283) | 3.37656632 |
| 24 | response to peptidoglycan (GO:0032494) | 3.36218760 |
| 25 | oligosaccharide catabolic process (GO:0009313) | 3.35349428 |
| 26 | superoxide anion generation (GO:0042554) | 3.33738950 |
| 27 | aromatic amino acid family catabolic process (GO:0009074) | 3.30326083 |
| 28 | regulation of podosome assembly (GO:0071801) | 3.26981131 |
| 29 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.25043455 |
| 30 | L-phenylalanine catabolic process (GO:0006559) | 3.24351569 |
| 31 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.24351569 |
| 32 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.23681419 |
| 33 | urea metabolic process (GO:0019627) | 3.23280065 |
| 34 | urea cycle (GO:0000050) | 3.23280065 |
| 35 | detection of external biotic stimulus (GO:0098581) | 3.17805717 |
| 36 | peptide catabolic process (GO:0043171) | 3.15982683 |
| 37 | glycosphingolipid catabolic process (GO:0046479) | 3.13385633 |
| 38 | flavonoid metabolic process (GO:0009812) | 3.10696815 |
| 39 | sulfur amino acid catabolic process (GO:0000098) | 3.10065496 |
| 40 | regulation of cholesterol esterification (GO:0010872) | 3.08857897 |
| 41 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 3.07858678 |
| 42 | negative regulation of interleukin-12 production (GO:0032695) | 3.07301919 |
| 43 | iron ion import (GO:0097286) | 3.06777590 |
| 44 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 3.06046995 |
| 45 | L-phenylalanine metabolic process (GO:0006558) | 3.06046995 |
| 46 | aldehyde catabolic process (GO:0046185) | 3.03365834 |
| 47 | T-helper 1 type immune response (GO:0042088) | 3.03216788 |
| 48 | urate metabolic process (GO:0046415) | 3.02686730 |
| 49 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.02498100 |
| 50 | detection of other organism (GO:0098543) | 3.02471384 |
| 51 | intestinal epithelial cell development (GO:0060576) | 3.00403248 |
| 52 | glycolipid catabolic process (GO:0019377) | 2.99893548 |
| 53 | cysteine metabolic process (GO:0006534) | 2.99571026 |
| 54 | phospholipid efflux (GO:0033700) | 2.99319184 |
| 55 | epoxygenase P450 pathway (GO:0019373) | 2.99059372 |
| 56 | nitrogen cycle metabolic process (GO:0071941) | 2.97789851 |
| 57 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.97304621 |
| 58 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.96793385 |
| 59 | signal peptide processing (GO:0006465) | 2.96602202 |
| 60 | homocysteine metabolic process (GO:0050667) | 2.94178748 |
| 61 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.92935810 |
| 62 | drug transmembrane transport (GO:0006855) | 2.92908815 |
| 63 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.92728310 |
| 64 | benzene-containing compound metabolic process (GO:0042537) | 2.91153057 |
| 65 | transcytosis (GO:0045056) | 2.90238996 |
| 66 | serine family amino acid catabolic process (GO:0009071) | 2.89631131 |
| 67 | drug transport (GO:0015893) | 2.89177925 |
| 68 | amine catabolic process (GO:0009310) | 2.87662866 |
| 69 | cellular biogenic amine catabolic process (GO:0042402) | 2.87662866 |
| 70 | positive regulation of interferon-alpha production (GO:0032727) | 2.86164185 |
| 71 | amino-acid betaine metabolic process (GO:0006577) | 2.84795524 |
| 72 | macrophage activation (GO:0042116) | 2.83826441 |
| 73 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.83439973 |
| 74 | drug catabolic process (GO:0042737) | 2.82099430 |
| 75 | cellular response to exogenous dsRNA (GO:0071360) | 2.80016577 |
| 76 | very-low-density lipoprotein particle assembly (GO:0034379) | 2.79553731 |
| 77 | regulation of gamma-delta T cell activation (GO:0046643) | 2.79001505 |
| 78 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.76648467 |
| 79 | cholesterol efflux (GO:0033344) | 2.76451976 |
| 80 | glyoxylate metabolic process (GO:0046487) | 2.75085138 |
| 81 | angiotensin maturation (GO:0002003) | 2.74964997 |
| 82 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.74226822 |
| 83 | phospholipid homeostasis (GO:0055091) | 2.72647631 |
| 84 | detection of bacterium (GO:0016045) | 2.71755981 |
| 85 | glutathione derivative biosynthetic process (GO:1901687) | 2.70823451 |
| 86 | glutathione derivative metabolic process (GO:1901685) | 2.70823451 |
| 87 | glucocorticoid biosynthetic process (GO:0006704) | 2.70789143 |
| 88 | interferon-gamma secretion (GO:0072643) | 2.70412933 |
| 89 | detection of biotic stimulus (GO:0009595) | 2.69823124 |
| 90 | response to type I interferon (GO:0034340) | 2.69208991 |
| 91 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.67119548 |
| 92 | regulation of interferon-alpha production (GO:0032647) | 2.66816990 |
| 93 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 2.66165101 |
| 94 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 2.66165101 |
| 95 | negative regulation of lipid storage (GO:0010888) | 2.64890487 |
| 96 | indolalkylamine metabolic process (GO:0006586) | 2.64734564 |
| 97 | membrane lipid catabolic process (GO:0046466) | 2.63595328 |
| 98 | type I interferon signaling pathway (GO:0060337) | 2.63456838 |
| 99 | cellular response to type I interferon (GO:0071357) | 2.63456838 |
| 100 | toxin transport (GO:1901998) | 2.63267061 |
| 101 | ceramide catabolic process (GO:0046514) | 2.63203007 |
| 102 | regulation of metalloenzyme activity (GO:0048552) | 2.62638327 |
| 103 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.62499840 |
| 104 | regulation of bile acid biosynthetic process (GO:0070857) | 2.62488989 |
| 105 | kynurenine metabolic process (GO:0070189) | 2.62018459 |
| 106 | regulation of vitamin metabolic process (GO:0030656) | 2.61917001 |
| 107 | regulation of RIG-I signaling pathway (GO:0039535) | 2.60960294 |
| 108 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 2.60608425 |
| 109 | cellular response to ethanol (GO:0071361) | 2.59262079 |
| 110 | NAD biosynthetic process (GO:0009435) | 2.58419754 |
| 111 | transepithelial transport (GO:0070633) | 2.58327061 |
| 112 | aromatic amino acid family metabolic process (GO:0009072) | 2.58087460 |
| 113 | respiratory burst (GO:0045730) | 2.55931433 |
| 114 | high-density lipoprotein particle remodeling (GO:0034375) | 2.55245854 |
| 115 | sphingolipid catabolic process (GO:0030149) | 2.55103659 |
| 116 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.54480186 |
| 117 | renal absorption (GO:0070293) | 2.53491120 |
| 118 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.52844749 |
| 119 | neutrophil activation (GO:0042119) | 2.52709333 |
| 120 | lipoprotein metabolic process (GO:0042157) | 2.52430456 |
| 121 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.51987734 |
| 122 | L-ascorbic acid metabolic process (GO:0019852) | 2.51550881 |
| 123 | granulocyte activation (GO:0036230) | 2.51194427 |
| 124 | reverse cholesterol transport (GO:0043691) | 2.50907686 |
| 125 | regulation of triglyceride catabolic process (GO:0010896) | 2.50756721 |
| 126 | glutathione metabolic process (GO:0006749) | 2.50500743 |
| 127 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.49825944 |
| 128 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 2.49594532 |
| 129 | amyloid precursor protein catabolic process (GO:0042987) | 2.49096683 |
| 130 | bile acid and bile salt transport (GO:0015721) | 2.48957627 |
| 131 | positive regulation of triglyceride lipase activity (GO:0061365) | 2.48890372 |
| 132 | positive regulation of lipoprotein lipase activity (GO:0051006) | 2.48890372 |
| 133 | immunoglobulin mediated immune response (GO:0016064) | 2.48112031 |
| 134 | cholesterol transport (GO:0030301) | 2.47270662 |
| 135 | sterol transport (GO:0015918) | 2.47270662 |
| 136 | dendritic cell chemotaxis (GO:0002407) | 2.46408038 |
| 137 | fructose metabolic process (GO:0006000) | 2.46350255 |
| 138 | hydrogen peroxide metabolic process (GO:0042743) | 2.45837740 |
| 139 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.45596888 |
| 140 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.45049048 |
| 141 | negative regulation of cell killing (GO:0031342) | 2.45049048 |
| 142 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.44971858 |
| 143 | protein carboxylation (GO:0018214) | 2.44971858 |
| 144 | hormone catabolic process (GO:0042447) | 2.44916596 |
| 145 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 2.44837888 |
| 146 | regulation of cytokine secretion involved in immune response (GO:0002739) | 2.44666968 |
| 147 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.44262084 |
| 148 | regulation of cellular extravasation (GO:0002691) | 2.43253950 |
| 149 | bile acid biosynthetic process (GO:0006699) | 2.42824972 |
| 150 | plasma lipoprotein particle assembly (GO:0034377) | 2.42821277 |
| 151 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 2.42388420 |
| 152 | folic acid transport (GO:0015884) | 2.42205975 |
| 153 | cholesterol homeostasis (GO:0042632) | 2.42124519 |
| 154 | fat-soluble vitamin biosynthetic process (GO:0042362) | 2.40584603 |
| 155 | response to host immune response (GO:0052572) | 2.40440489 |
| 156 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.40440489 |
| 157 | regulation of toll-like receptor 4 signaling pathway (GO:0034143) | 2.40379784 |
| 158 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.38617083 |
| 159 | diol metabolic process (GO:0034311) | 2.38074110 |
| 160 | sphingomyelin metabolic process (GO:0006684) | 2.37689870 |
| 161 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 2.34626615 |
| 162 | positive regulation of heat generation (GO:0031652) | 2.32856491 |
| 163 | vitamin D metabolic process (GO:0042359) | 2.32459930 |
| 164 | cellular extravasation (GO:0045123) | 2.31214648 |
| 165 | sphingoid metabolic process (GO:0046519) | 2.31131589 |
| 166 | sulfate transmembrane transport (GO:1902358) | 2.30447978 |
| 167 | microglial cell activation (GO:0001774) | 2.29452438 |
| 168 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.25036785 |
| 169 | regulation of mononuclear cell migration (GO:0071675) | 2.24991969 |
| 170 | sphingosine metabolic process (GO:0006670) | 2.24988782 |
| 171 | positive regulation of leukocyte degranulation (GO:0043302) | 2.24256175 |
| 172 | epithelial structure maintenance (GO:0010669) | 2.23186588 |
| 173 | negative regulation of toll-like receptor signaling pathway (GO:0034122) | 2.22556385 |
| 174 | dendritic cell migration (GO:0036336) | 2.19288510 |
| 175 | germinal center formation (GO:0002467) | 2.18441505 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.17629642 |
| 2 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 5.05602543 |
| 3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.38370057 |
| 4 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 4.25839023 |
| 5 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 3.86865442 |
| 6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.72338393 |
| 7 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 3.40347279 |
| 8 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 3.39930086 |
| 9 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.19756354 |
| 10 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.02449667 |
| 11 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.87801655 |
| 12 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.80751070 |
| 13 | * FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.53649694 |
| 14 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.49652267 |
| 15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.47934512 |
| 16 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.44595450 |
| 17 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.42465916 |
| 18 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.41376298 |
| 19 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.40192134 |
| 20 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.20097489 |
| 21 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.12295953 |
| 22 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 2.10715114 |
| 23 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.10071287 |
| 24 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 2.02636559 |
| 25 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.99773222 |
| 26 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.95930125 |
| 27 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.95093169 |
| 28 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.83166373 |
| 29 | * ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.82836906 |
| 30 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.81627460 |
| 31 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.77449802 |
| 32 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.74406751 |
| 33 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.71407164 |
| 34 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.67589729 |
| 35 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.64552129 |
| 36 | * FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.61640759 |
| 37 | GATA1_22025678_ChIP-Seq_K562_Human | 1.61391762 |
| 38 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.60596688 |
| 39 | * SPI1_23127762_ChIP-Seq_K562_Human | 1.52697626 |
| 40 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.47340234 |
| 41 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.47252046 |
| 42 | * VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.44527514 |
| 43 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.44406736 |
| 44 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.44208569 |
| 45 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.42987549 |
| 46 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.42612006 |
| 47 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.41913399 |
| 48 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.39681038 |
| 49 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.33061702 |
| 50 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.30730853 |
| 51 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.27836505 |
| 52 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.27551072 |
| 53 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.26964568 |
| 54 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.25043462 |
| 55 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.24091667 |
| 56 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.24075493 |
| 57 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.23708253 |
| 58 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.22947783 |
| 59 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 1.20599557 |
| 60 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.18890015 |
| 61 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.16859977 |
| 62 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.16710915 |
| 63 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.16665032 |
| 64 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.15333971 |
| 65 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.13922100 |
| 66 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.13366479 |
| 67 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.13147749 |
| 68 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12259135 |
| 69 | * KLF5_25053715_ChIP-Seq_YYC3_Human | 1.11906598 |
| 70 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10336750 |
| 71 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.10287523 |
| 72 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.10262633 |
| 73 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.09655958 |
| 74 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.09570884 |
| 75 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.08761732 |
| 76 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.08595952 |
| 77 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.06335539 |
| 78 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.02803238 |
| 79 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01207441 |
| 80 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99999794 |
| 81 | * CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.99657778 |
| 82 | GATA2_19941826_ChIP-Seq_K562_Human | 0.98856419 |
| 83 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.97799574 |
| 84 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.97451192 |
| 85 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.97357247 |
| 86 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.96696395 |
| 87 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.96574375 |
| 88 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.96314006 |
| 89 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.96304423 |
| 90 | GATA1_19941826_ChIP-Seq_K562_Human | 0.95850281 |
| 91 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.95706943 |
| 92 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.95658857 |
| 93 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.95208150 |
| 94 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.95152620 |
| 95 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.94475308 |
| 96 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.93885947 |
| 97 | * TP63_23658742_ChIP-Seq_EP156T_Human | 0.93824187 |
| 98 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.93753539 |
| 99 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.93160666 |
| 100 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.92895742 |
| 101 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.92472127 |
| 102 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.92315445 |
| 103 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.92101819 |
| 104 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.90995358 |
| 105 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.90694782 |
| 106 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90175115 |
| 107 | * EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.89950115 |
| 108 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.89570613 |
| 109 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.89325252 |
| 110 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.89144327 |
| 111 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 0.88735395 |
| 112 | * SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87847110 |
| 113 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.87564827 |
| 114 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.87321611 |
| 115 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.87290053 |
| 116 | * TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.87164568 |
| 117 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.85265583 |
| 118 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.84431043 |
| 119 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.84370447 |
| 120 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.84326750 |
| 121 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82989832 |
| 122 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.82971564 |
| 123 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.82900534 |
| 124 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.82900534 |
| 125 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.82320144 |
| 126 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.82320144 |
| 127 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.81910849 |
| 128 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81891280 |
| 129 | * FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.81707554 |
| 130 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.81330387 |
| 131 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.81146381 |
| 132 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.79750632 |
| 133 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.79577794 |
| 134 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78550615 |
| 135 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.78231232 |
| 136 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.77849213 |
| 137 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.77638767 |
| 138 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.77638767 |
| 139 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.77638767 |
| 140 | MYB_26560356_Chip-Seq_TH2_Human | 0.77634937 |
| 141 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.77469266 |
| 142 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.77330015 |
| 143 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.76411611 |
| 144 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.75575487 |
| 145 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.75524227 |
| 146 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.75501600 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 4.48201502 |
| 2 | MP0005360_urolithiasis | 4.31039446 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 3.36197577 |
| 4 | MP0003303_peritoneal_inflammation | 3.16796125 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 3.11619475 |
| 6 | MP0005365_abnormal_bile_salt | 2.97399155 |
| 7 | MP0010234_abnormal_vibrissa_follicle | 2.93924268 |
| 8 | MP0003195_calcinosis | 2.71039085 |
| 9 | MP0004019_abnormal_vitamin_homeostasis | 2.52715704 |
| 10 | MP0001666_abnormal_nutrient_absorption | 2.46208580 |
| 11 | MP0009840_abnormal_foam_cell | 2.43493498 |
| 12 | MP0001835_abnormal_antigen_presentation | 2.41123171 |
| 13 | MP0002138_abnormal_hepatobiliary_system | 2.35068514 |
| 14 | MP0003252_abnormal_bile_duct | 2.26604754 |
| 15 | MP0003436_decreased_susceptibility_to | 2.12326465 |
| 16 | MP0005332_abnormal_amino_acid | 2.04903443 |
| 17 | MP0003186_abnormal_redox_activity | 1.99149503 |
| 18 | MP0009785_altered_susceptibility_to | 1.99038453 |
| 19 | MP0003724_increased_susceptibility_to | 1.97353909 |
| 20 | MP0005058_abnormal_lysosome_morphology | 1.96386034 |
| 21 | MP0004782_abnormal_surfactant_physiolog | 1.94434095 |
| 22 | MP0002148_abnormal_hypersensitivity_rea | 1.91491878 |
| 23 | MP0003191_abnormal_cellular_cholesterol | 1.88691770 |
| 24 | MP0010329_abnormal_lipoprotein_level | 1.79835085 |
| 25 | MP0003806_abnormal_nucleotide_metabolis | 1.76974243 |
| 26 | MP0009643_abnormal_urine_homeostasis | 1.76706083 |
| 27 | MP0002277_abnormal_respiratory_mucosa | 1.76500896 |
| 28 | MP0010352_gastrointestinal_tract_polyps | 1.64455130 |
| 29 | MP0002419_abnormal_innate_immunity | 1.63070834 |
| 30 | MP0009764_decreased_sensitivity_to | 1.61488177 |
| 31 | MP0006082_CNS_inflammation | 1.59692557 |
| 32 | MP0005025_abnormal_response_to | 1.59424576 |
| 33 | MP0002876_abnormal_thyroid_physiology | 1.59142581 |
| 34 | MP0004043_abnormal_pH_regulation | 1.58689865 |
| 35 | MP0001765_abnormal_ion_homeostasis | 1.57392064 |
| 36 | MP0003183_abnormal_peptide_metabolism | 1.47276141 |
| 37 | MP0005084_abnormal_gallbladder_morpholo | 1.46353557 |
| 38 | MP0005408_hypopigmentation | 1.43149855 |
| 39 | MP0005000_abnormal_immune_tolerance | 1.42433034 |
| 40 | MP0002254_reproductive_system_inflammat | 1.40182222 |
| 41 | MP0001764_abnormal_homeostasis | 1.40094229 |
| 42 | MP0008469_abnormal_protein_level | 1.39065754 |
| 43 | MP0000609_abnormal_liver_physiology | 1.35276394 |
| 44 | MP0004264_abnormal_extraembryonic_tissu | 1.34662669 |
| 45 | MP0010155_abnormal_intestine_physiology | 1.32957778 |
| 46 | MP0005387_immune_system_phenotype | 1.32644397 |
| 47 | MP0001790_abnormal_immune_system | 1.32644397 |
| 48 | MP0005083_abnormal_biliary_tract | 1.32470956 |
| 49 | MP0002998_abnormal_bone_remodeling | 1.32147449 |
| 50 | MP0005310_abnormal_salivary_gland | 1.32043614 |
| 51 | MP0005166_decreased_susceptibility_to | 1.30859520 |
| 52 | MP0008260_abnormal_autophagy | 1.28492373 |
| 53 | MP0001845_abnormal_inflammatory_respons | 1.27943825 |
| 54 | MP0001756_abnormal_urination | 1.27306613 |
| 55 | MP0003172_abnormal_lysosome_physiology | 1.26802086 |
| 56 | MP0005319_abnormal_enzyme/_coenzyme | 1.26516990 |
| 57 | MP0003075_altered_response_to | 1.26079362 |
| 58 | MP0002132_abnormal_respiratory_system | 1.22764532 |
| 59 | MP0005671_abnormal_response_to | 1.21871841 |
| 60 | MP0010678_abnormal_skin_adnexa | 1.21653573 |
| 61 | MP0002136_abnormal_kidney_physiology | 1.20524281 |
| 62 | MP0003300_gastrointestinal_ulcer | 1.20303486 |
| 63 | MP0001501_abnormal_sleep_pattern | 1.19869588 |
| 64 | MP0002796_impaired_skin_barrier | 1.17722173 |
| 65 | MP0003879_abnormal_hair_cell | 1.17320467 |
| 66 | MP0002452_abnormal_antigen_presenting | 1.14841128 |
| 67 | MP0002909_abnormal_adrenal_gland | 1.14653208 |
| 68 | MP0005636_abnormal_mineral_homeostasis | 1.13537926 |
| 69 | MP0004510_myositis | 1.12452769 |
| 70 | MP0002118_abnormal_lipid_homeostasis | 1.12173364 |
| 71 | MP0005451_abnormal_body_composition | 1.10969913 |
| 72 | MP0002723_abnormal_immune_serum | 1.09805082 |
| 73 | MP0000685_abnormal_immune_system | 1.08750185 |
| 74 | MP0004381_abnormal_hair_follicle | 1.06300919 |
| 75 | MP0002009_preneoplasia | 1.06156985 |
| 76 | MP0001853_heart_inflammation | 1.06107070 |
| 77 | MP0003045_fibrosis | 1.01823772 |
| 78 | MP0003718_maternal_effect | 1.01616469 |
| 79 | MP0000604_amyloidosis | 1.00479216 |
| 80 | MP0005464_abnormal_platelet_physiology | 1.00259374 |
| 81 | MP0003866_abnormal_defecation | 0.99720073 |
| 82 | MP0001800_abnormal_humoral_immune | 0.99079702 |
| 83 | MP0002098_abnormal_vibrissa_morphology | 0.99061812 |
| 84 | MP0003878_abnormal_ear_physiology | 0.99036156 |
| 85 | MP0005377_hearing/vestibular/ear_phenot | 0.99036156 |
| 86 | MP0002006_tumorigenesis | 0.97694100 |
| 87 | MP0005220_abnormal_exocrine_pancreas | 0.95010171 |
| 88 | MP0010386_abnormal_urinary_bladder | 0.94565206 |
| 89 | MP0009278_abnormal_bone_marrow | 0.94529183 |
| 90 | MP0005076_abnormal_cell_differentiation | 0.93994725 |
| 91 | MP0003690_abnormal_glial_cell | 0.93684934 |
| 92 | MP0002405_respiratory_system_inflammati | 0.93446144 |
| 93 | MP0001533_abnormal_skeleton_physiology | 0.92398739 |
| 94 | MP0002693_abnormal_pancreas_physiology | 0.92259783 |
| 95 | MP0005397_hematopoietic_system_phenotyp | 0.91964559 |
| 96 | MP0001545_abnormal_hematopoietic_system | 0.91964559 |
| 97 | MP0000613_abnormal_salivary_gland | 0.90612675 |
| 98 | MP0005647_abnormal_sex_gland | 0.90319553 |
| 99 | MP0005167_abnormal_blood-brain_barrier | 0.90306569 |
| 100 | MP0003868_abnormal_feces_composition | 0.90180953 |
| 101 | MP0001819_abnormal_immune_cell | 0.89245925 |
| 102 | MP0002166_altered_tumor_susceptibility | 0.88435191 |
| 103 | MP0008004_abnormal_stomach_pH | 0.86279493 |
| 104 | MP0002420_abnormal_adaptive_immunity | 0.86055783 |
| 105 | MP0009763_increased_sensitivity_to | 0.86037367 |
| 106 | MP0000538_abnormal_urinary_bladder | 0.85318385 |
| 107 | MP0004947_skin_inflammation | 0.85296143 |
| 108 | MP0003453_abnormal_keratinocyte_physiol | 0.84742792 |
| 109 | MP0009765_abnormal_xenobiotic_induced | 0.84668563 |
| 110 | MP0001881_abnormal_mammary_gland | 0.83140576 |
| 111 | MP0000470_abnormal_stomach_morphology | 0.82897962 |
| 112 | MP0001664_abnormal_digestion | 0.82752054 |
| 113 | MP0000371_diluted_coat_color | 0.82581288 |
| 114 | MP0004883_abnormal_blood_vessel | 0.82242050 |
| 115 | MP0005164_abnormal_response_to | 0.81844787 |
| 116 | MP0002877_abnormal_melanocyte_morpholog | 0.81708042 |
| 117 | MP0005670_abnormal_white_adipose | 0.81548402 |
| 118 | MP0000858_altered_metastatic_potential | 0.81154831 |
| 119 | MP0000383_abnormal_hair_follicle | 0.80009374 |
| 120 | MP0000678_abnormal_parathyroid_gland | 0.79924462 |
| 121 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.79879419 |
| 122 | MP0000716_abnormal_immune_system | 0.79204302 |
| 123 | MP0001873_stomach_inflammation | 0.79099150 |
| 124 | MP0000490_abnormal_crypts_of | 0.77606239 |
| 125 | MP0001663_abnormal_digestive_system | 0.77054678 |
| 126 | MP0002928_abnormal_bile_duct | 0.76355755 |
| 127 | MP0000566_synostosis | 0.76302044 |
| 128 | MP0009642_abnormal_blood_homeostasis | 0.76106755 |
| 129 | MP0000598_abnormal_liver_morphology | 0.75777120 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Vacuolated lymphocytes (HP:0001922) | 4.28376431 |
| 2 | Decreased circulating renin level (HP:0003351) | 4.10640730 |
| 3 | Increased cerebral lipofuscin (HP:0011813) | 3.99295132 |
| 4 | Hyperglycinuria (HP:0003108) | 3.97100098 |
| 5 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.83245317 |
| 6 | Eczematoid dermatitis (HP:0000976) | 3.66178245 |
| 7 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.64917618 |
| 8 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.62971118 |
| 9 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.55658622 |
| 10 | Recurrent bacterial skin infections (HP:0005406) | 3.42004944 |
| 11 | Recurrent abscess formation (HP:0002722) | 3.41593609 |
| 12 | Hyperactive renin-angiotensin system (HP:0000841) | 3.35016133 |
| 13 | Abnormality of chloride homeostasis (HP:0011422) | 3.31761952 |
| 14 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.29163773 |
| 15 | Conjugated hyperbilirubinemia (HP:0002908) | 3.22579911 |
| 16 | Intrahepatic cholestasis (HP:0001406) | 3.18525609 |
| 17 | Prolonged partial thromboplastin time (HP:0003645) | 3.15670073 |
| 18 | Abnormality of macrophages (HP:0004311) | 3.14633943 |
| 19 | Orchitis (HP:0100796) | 3.14434174 |
| 20 | Joint hemorrhage (HP:0005261) | 3.13266693 |
| 21 | Retrobulbar optic neuritis (HP:0100654) | 2.97719973 |
| 22 | Optic neuritis (HP:0100653) | 2.97719973 |
| 23 | Loss of speech (HP:0002371) | 2.97497649 |
| 24 | Systemic lupus erythematosus (HP:0002725) | 2.96598939 |
| 25 | Generalized aminoaciduria (HP:0002909) | 2.92521688 |
| 26 | Hyperglycinemia (HP:0002154) | 2.92289859 |
| 27 | Abnormality of glycine metabolism (HP:0010895) | 2.91106214 |
| 28 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.91106214 |
| 29 | Fat malabsorption (HP:0002630) | 2.90210098 |
| 30 | Autoimmune thrombocytopenia (HP:0001973) | 2.85343064 |
| 31 | Prolonged neonatal jaundice (HP:0006579) | 2.81139948 |
| 32 | Xanthomatosis (HP:0000991) | 2.80019517 |
| 33 | Proximal tubulopathy (HP:0000114) | 2.77291922 |
| 34 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.77281492 |
| 35 | Abnormality of proline metabolism (HP:0010907) | 2.76405742 |
| 36 | Hydroxyprolinuria (HP:0003080) | 2.76405742 |
| 37 | Myositis (HP:0100614) | 2.71337198 |
| 38 | Abnormality of purine metabolism (HP:0004352) | 2.69657414 |
| 39 | Glycosuria (HP:0003076) | 2.66136796 |
| 40 | Abnormality of urine glucose concentration (HP:0011016) | 2.66136796 |
| 41 | Renal salt wasting (HP:0000127) | 2.65245983 |
| 42 | Hypobetalipoproteinemia (HP:0003563) | 2.63881774 |
| 43 | Glomerulonephritis (HP:0000099) | 2.61443715 |
| 44 | Abnormality of nucleobase metabolism (HP:0010932) | 2.61085048 |
| 45 | Hypoglycemic coma (HP:0001325) | 2.52961709 |
| 46 | Amelogenesis imperfecta (HP:0000705) | 2.51809615 |
| 47 | Reduced antithrombin III activity (HP:0001976) | 2.50196666 |
| 48 | Nausea (HP:0002018) | 2.46852123 |
| 49 | Gout (HP:0001997) | 2.46324509 |
| 50 | Alkalosis (HP:0001948) | 2.45322246 |
| 51 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.43940317 |
| 52 | Gingivitis (HP:0000230) | 2.42469752 |
| 53 | Pustule (HP:0200039) | 2.41328754 |
| 54 | Genetic anticipation (HP:0003743) | 2.37586777 |
| 55 | Chronic bronchitis (HP:0004469) | 2.34482748 |
| 56 | Vascular calcification (HP:0004934) | 2.32684509 |
| 57 | Ileus (HP:0002595) | 2.32507310 |
| 58 | Chronic diarrhea (HP:0002028) | 2.31324296 |
| 59 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.31082520 |
| 60 | Abnormality of the common coagulation pathway (HP:0010990) | 2.27289738 |
| 61 | Stomatitis (HP:0010280) | 2.26557834 |
| 62 | Nasal polyposis (HP:0100582) | 2.25585934 |
| 63 | Myocardial infarction (HP:0001658) | 2.22922261 |
| 64 | Amyloidosis (HP:0011034) | 2.21476928 |
| 65 | Flat acetabular roof (HP:0003180) | 2.21299430 |
| 66 | Disinhibition (HP:0000734) | 2.21267009 |
| 67 | Epidermoid cyst (HP:0200040) | 2.21248768 |
| 68 | Renal tubular acidosis (HP:0001947) | 2.19744564 |
| 69 | Recurrent skin infections (HP:0001581) | 2.17829258 |
| 70 | Metabolic alkalosis (HP:0200114) | 2.17546762 |
| 71 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.16856894 |
| 72 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.16856894 |
| 73 | Abnormality of glycolipid metabolism (HP:0010969) | 2.16856894 |
| 74 | Dysostosis multiplex (HP:0000943) | 2.16122742 |
| 75 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.16070130 |
| 76 | Cheilitis (HP:0100825) | 2.15903998 |
| 77 | Hypokalemia (HP:0002900) | 2.15462593 |
| 78 | Chronic otitis media (HP:0000389) | 2.14967074 |
| 79 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.13829490 |
| 80 | Abnormality of the nasal mucosa (HP:0000433) | 2.13642854 |
| 81 | Malnutrition (HP:0004395) | 2.12908040 |
| 82 | Steatorrhea (HP:0002570) | 2.12726796 |
| 83 | Bronchiectasis (HP:0002110) | 2.09038175 |
| 84 | Complement deficiency (HP:0004431) | 2.08548163 |
| 85 | Increased circulating renin level (HP:0000848) | 2.07943876 |
| 86 | Abnormality of potassium homeostasis (HP:0011042) | 2.07793169 |
| 87 | Prostate neoplasm (HP:0100787) | 2.06056054 |
| 88 | Hypercholesterolemia (HP:0003124) | 2.04660551 |
| 89 | Abnormality of the intrinsic pathway (HP:0010989) | 2.04083384 |
| 90 | Dysmetric saccades (HP:0000641) | 2.03028480 |
| 91 | Bronchitis (HP:0012387) | 2.03006617 |
| 92 | Renal cortical cysts (HP:0000803) | 2.02728448 |
| 93 | Nephritis (HP:0000123) | 2.02674029 |
| 94 | Keratoconjunctivitis sicca (HP:0001097) | 2.02491952 |
| 95 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.00399971 |
| 96 | Mucopolysacchariduria (HP:0008155) | 2.00399971 |
| 97 | Widely patent fontanelles and sutures (HP:0004492) | 1.99688156 |
| 98 | Right ventricular cardiomyopathy (HP:0011663) | 1.98785829 |
| 99 | Periodontitis (HP:0000704) | 1.98715591 |
| 100 | Hyperammonemia (HP:0001987) | 1.98265972 |
| 101 | Increased CSF protein (HP:0002922) | 1.97728256 |
| 102 | Pancreatitis (HP:0001733) | 1.97195539 |
| 103 | Vasculitis (HP:0002633) | 1.96652943 |
| 104 | Esophageal varix (HP:0002040) | 1.96474710 |
| 105 | Alveolar cell carcinoma (HP:0006519) | 1.96236505 |
| 106 | Abnormality of renin-angiotensin system (HP:0000847) | 1.96163786 |
| 107 | Mediastinal lymphadenopathy (HP:0100721) | 1.95483381 |
| 108 | Hypolipoproteinemia (HP:0010981) | 1.95022257 |
| 109 | Cone-rod dystrophy (HP:0000548) | 1.94319778 |
| 110 | Hypophosphatemia (HP:0002148) | 1.93421958 |
| 111 | Axonal loss (HP:0003447) | 1.92693713 |
| 112 | Hematochezia (HP:0002573) | 1.91512085 |
| 113 | Increased purine levels (HP:0004368) | 1.91092967 |
| 114 | Hyperuricemia (HP:0002149) | 1.91092967 |
| 115 | Abnormality of complement system (HP:0005339) | 1.90075584 |
| 116 | Congenital sensorineural hearing impairment (HP:0008527) | 1.89440551 |
| 117 | Cardiovascular calcification (HP:0011915) | 1.89426952 |
| 118 | Tetany (HP:0001281) | 1.89066359 |
| 119 | Type I transferrin isoform profile (HP:0003642) | 1.89017042 |
| 120 | Symptomatic seizures (HP:0011145) | 1.88889975 |
| 121 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.87949756 |
| 122 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.87949756 |
| 123 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.87949756 |
| 124 | Hyperaldosteronism (HP:0000859) | 1.87306928 |
| 125 | Interstitial pulmonary disease (HP:0006530) | 1.87223849 |
| 126 | Hyperkalemia (HP:0002153) | 1.87159402 |
| 127 | Anorexia (HP:0002039) | 1.86194505 |
| 128 | Dehydration (HP:0001944) | 1.85342942 |
| 129 | Lip pit (HP:0100267) | 1.84978759 |
| 130 | Exocrine pancreatic insufficiency (HP:0001738) | 1.83928538 |
| 131 | Hypoglycemic seizures (HP:0002173) | 1.83730858 |
| 132 | Keratoconjunctivitis (HP:0001096) | 1.83654711 |
| 133 | Abdominal distention (HP:0003270) | 1.83628270 |
| 134 | Recurrent fungal infections (HP:0002841) | 1.81801944 |
| 135 | Hypokalemic alkalosis (HP:0001949) | 1.81791193 |
| 136 | Osteomalacia (HP:0002749) | 1.81450361 |
| 137 | Recurrent bronchitis (HP:0002837) | 1.81366777 |
| 138 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.81289013 |
| 139 | Absent/shortened dynein arms (HP:0200106) | 1.81289013 |
| 140 | Abnormality of renal excretion (HP:0011036) | 1.80966792 |
| 141 | Azoospermia (HP:0000027) | 1.80844038 |
| 142 | Lethargy (HP:0001254) | 1.80639916 |
| 143 | Progressive visual loss (HP:0000529) | 1.79263183 |
| 144 | Increased IgE level (HP:0003212) | 1.78745089 |
| 145 | Hemoptysis (HP:0002105) | 1.76920770 |
| 146 | Pulmonary infiltrates (HP:0002113) | 1.76846210 |
| 147 | Rickets (HP:0002748) | 1.75777472 |
| 148 | Chronic sinusitis (HP:0011109) | 1.74734639 |
| 149 | Premature loss of primary teeth (HP:0006323) | 1.73288269 |
| 150 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.72248041 |
| 151 | Increased serum ferritin (HP:0003281) | 1.71840317 |
| 152 | Urticaria (HP:0001025) | 1.71353464 |
| 153 | Recurrent sinusitis (HP:0011108) | 1.68837558 |
| 154 | Adrenal overactivity (HP:0002717) | 1.68739647 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRAK3 | 4.90025150 |
| 2 | ACVR1B | 4.08401039 |
| 3 | IRAK4 | 3.35556885 |
| 4 | MAP3K14 | 3.32641796 |
| 5 | MST4 | 3.16931025 |
| 6 | FRK | 3.14028878 |
| 7 | EPHA2 | 2.71212581 |
| 8 | TAOK1 | 2.66885815 |
| 9 | PBK | 2.63041579 |
| 10 | MST1R | 2.32374766 |
| 11 | OXSR1 | 2.27024656 |
| 12 | LMTK2 | 2.05956471 |
| 13 | TAOK3 | 2.05553889 |
| 14 | MATK | 1.98305082 |
| 15 | AKT3 | 1.89046874 |
| 16 | CAMK1D | 1.80866231 |
| 17 | BCKDK | 1.78328826 |
| 18 | RIPK1 | 1.77880119 |
| 19 | TBK1 | 1.77723727 |
| 20 | IKBKE | 1.77481943 |
| 21 | INSRR | 1.74885356 |
| 22 | STK24 | 1.74025127 |
| 23 | EIF2AK3 | 1.71988973 |
| 24 | IRAK1 | 1.68163218 |
| 25 | NUAK1 | 1.67161665 |
| 26 | ZAK | 1.63954302 |
| 27 | RIPK4 | 1.60625282 |
| 28 | TNK2 | 1.57014588 |
| 29 | NLK | 1.55718656 |
| 30 | BLK | 1.55187049 |
| 31 | IKBKB | 1.54939840 |
| 32 | FGR | 1.53508915 |
| 33 | NME2 | 1.51292124 |
| 34 | TRIB3 | 1.51023748 |
| 35 | TYK2 | 1.50734819 |
| 36 | ERN1 | 1.40501749 |
| 37 | MAP3K3 | 1.39563900 |
| 38 | TXK | 1.35674797 |
| 39 | IRAK2 | 1.34056561 |
| 40 | FER | 1.31980887 |
| 41 | BMPR2 | 1.31371499 |
| 42 | MAP3K13 | 1.28733502 |
| 43 | MAPK15 | 1.27493460 |
| 44 | CHUK | 1.24543338 |
| 45 | STK38L | 1.23277504 |
| 46 | CDC42BPA | 1.23050765 |
| 47 | NEK9 | 1.22870599 |
| 48 | DDR2 | 1.20686384 |
| 49 | PRKG2 | 1.20167948 |
| 50 | CAMK1G | 1.18950034 |
| 51 | STK39 | 1.18020090 |
| 52 | MAP3K1 | 1.17830230 |
| 53 | EIF2AK2 | 1.16381134 |
| 54 | PIM2 | 1.13623091 |
| 55 | TEC | 1.12171100 |
| 56 | JAK3 | 1.09766141 |
| 57 | FGFR4 | 1.02435132 |
| 58 | PRKAA2 | 1.01991953 |
| 59 | PIM1 | 1.01529229 |
| 60 | MAP2K2 | 0.98562677 |
| 61 | JAK1 | 0.97795726 |
| 62 | WNK4 | 0.95852982 |
| 63 | PDPK1 | 0.93840983 |
| 64 | DAPK2 | 0.91927219 |
| 65 | EPHA3 | 0.90465995 |
| 66 | MAP3K2 | 0.87564615 |
| 67 | CLK1 | 0.85457939 |
| 68 | PIK3CG | 0.85113317 |
| 69 | MAP2K6 | 0.85048806 |
| 70 | CSK | 0.83995296 |
| 71 | ZAP70 | 0.83977891 |
| 72 | YES1 | 0.82796703 |
| 73 | PRPF4B | 0.81680726 |
| 74 | CSF1R | 0.81453524 |
| 75 | STK10 | 0.78381854 |
| 76 | MARK2 | 0.76165564 |
| 77 | STK16 | 0.73930854 |
| 78 | ABL2 | 0.73000422 |
| 79 | GRK1 | 0.70343666 |
| 80 | ADRBK2 | 0.70010654 |
| 81 | LATS1 | 0.69175408 |
| 82 | JAK2 | 0.69165569 |
| 83 | WNK3 | 0.68842906 |
| 84 | PDK1 | 0.66316093 |
| 85 | CDK12 | 0.65964491 |
| 86 | STK38 | 0.65157787 |
| 87 | SMG1 | 0.64716295 |
| 88 | MELK | 0.63955627 |
| 89 | SGK2 | 0.63560729 |
| 90 | BTK | 0.63336825 |
| 91 | HCK | 0.62066888 |
| 92 | PRKCI | 0.61175703 |
| 93 | DYRK1B | 0.60810612 |
| 94 | MAP2K3 | 0.59455950 |
| 95 | SRPK1 | 0.58972941 |
| 96 | KIT | 0.58880561 |
| 97 | RPS6KA4 | 0.57884215 |
| 98 | TLK1 | 0.57031195 |
| 99 | STK4 | 0.56271965 |
| 100 | PRKCD | 0.56238983 |
| 101 | NEK6 | 0.55992072 |
| 102 | MAP3K11 | 0.55631343 |
| 103 | EPHB1 | 0.55518155 |
| 104 | LYN | 0.55305206 |
| 105 | PLK4 | 0.53460357 |
| 106 | ICK | 0.52888568 |
| 107 | MAP4K1 | 0.50932064 |
| 108 | TESK1 | 0.50440157 |
| 109 | TNIK | 0.50099325 |
| 110 | STK3 | 0.49655668 |
| 111 | ERBB4 | 0.49590622 |
| 112 | TGFBR2 | 0.49152846 |
| 113 | ERBB3 | 0.48514250 |
| 114 | TAOK2 | 0.48464603 |
| 115 | NME1 | 0.48249716 |
| 116 | GRK7 | 0.48202815 |
| 117 | PIK3CA | 0.48096233 |
| 118 | HIPK2 | 0.47298764 |
| 119 | CDK6 | 0.44991011 |
| 120 | PDK2 | 0.44654496 |
| 121 | TRPM7 | 0.44369850 |
| 122 | GRK6 | 0.41839395 |
| 123 | MKNK2 | 0.41398723 |
| 124 | MAP3K7 | 0.41333669 |
| 125 | PAK4 | 0.41303154 |
| 126 | BMPR1B | 0.40444987 |
| 127 | ERBB2 | 0.38482534 |
| 128 | MET | 0.38475273 |
| 129 | PRKCZ | 0.38340446 |
| 130 | LCK | 0.37113113 |
| 131 | FGFR3 | 0.35988050 |
| 132 | SGK3 | 0.35282498 |
| 133 | PRKD2 | 0.35128749 |
| 134 | PTK6 | 0.34690161 |
| 135 | SYK | 0.33390600 |
| 136 | MAPK11 | 0.33042409 |
| 137 | ABL1 | 0.32866503 |
| 138 | PINK1 | 0.32520403 |
| 139 | SIK3 | 0.32136030 |
| 140 | SIK1 | 0.30770824 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 3.51729943 |
| 2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.14913154 |
| 3 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.79658284 |
| 4 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.54384953 |
| 5 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.30327124 |
| 6 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.21047555 |
| 7 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.12679706 |
| 8 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.06863885 |
| 9 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.98153757 |
| 10 | Histidine metabolism_Homo sapiens_hsa00340 | 1.93507674 |
| 11 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.90535129 |
| 12 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.88831554 |
| 13 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.87566257 |
| 14 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.86288682 |
| 15 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.82569139 |
| 16 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.81218257 |
| 17 | Peroxisome_Homo sapiens_hsa04146 | 1.78452919 |
| 18 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.77345411 |
| 19 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.66683788 |
| 20 | Retinol metabolism_Homo sapiens_hsa00830 | 1.62579785 |
| 21 | Mineral absorption_Homo sapiens_hsa04978 | 1.60494494 |
| 22 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.54483851 |
| 23 | Other glycan degradation_Homo sapiens_hsa00511 | 1.54135803 |
| 24 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.52400980 |
| 25 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.49488256 |
| 26 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.47225660 |
| 27 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.44922019 |
| 28 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.43646212 |
| 29 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.43100891 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.41446772 |
| 31 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.40913229 |
| 32 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.39742039 |
| 33 | Protein export_Homo sapiens_hsa03060 | 1.39179049 |
| 34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.38940860 |
| 35 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.37885414 |
| 36 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.36221269 |
| 37 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.31041871 |
| 38 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.30993254 |
| 39 | Galactose metabolism_Homo sapiens_hsa00052 | 1.28138857 |
| 40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.26977117 |
| 41 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.19220720 |
| 42 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.19114397 |
| 43 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.18877219 |
| 44 | Legionellosis_Homo sapiens_hsa05134 | 1.17649292 |
| 45 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.17001466 |
| 46 | Sulfur relay system_Homo sapiens_hsa04122 | 1.12903453 |
| 47 | Lysosome_Homo sapiens_hsa04142 | 1.11505738 |
| 48 | ABC transporters_Homo sapiens_hsa02010 | 1.06609984 |
| 49 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.02964969 |
| 50 | Leishmaniasis_Homo sapiens_hsa05140 | 1.02772156 |
| 51 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.02384464 |
| 52 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.99349445 |
| 53 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.99292784 |
| 54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.97451698 |
| 55 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.96628607 |
| 56 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.96201680 |
| 57 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.93932183 |
| 58 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.93836208 |
| 59 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.93346752 |
| 60 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.93286245 |
| 61 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.91993852 |
| 62 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.85513851 |
| 63 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.83927002 |
| 64 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.83214278 |
| 65 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.82804510 |
| 66 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.82356997 |
| 67 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.79191491 |
| 68 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.76951183 |
| 69 | Insulin resistance_Homo sapiens_hsa04931 | 0.76726532 |
| 70 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.76348537 |
| 71 | Allograft rejection_Homo sapiens_hsa05330 | 0.75382890 |
| 72 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.74191428 |
| 73 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.74105676 |
| 74 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.74012431 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73945591 |
| 76 | Pertussis_Homo sapiens_hsa05133 | 0.73629718 |
| 77 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.73335553 |
| 78 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.73065549 |
| 79 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.73051368 |
| 80 | Influenza A_Homo sapiens_hsa05164 | 0.71659131 |
| 81 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71238156 |
| 82 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.70558958 |
| 83 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.69218873 |
| 84 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.69136381 |
| 85 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.68260120 |
| 86 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.67484998 |
| 87 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.67449104 |
| 88 | Measles_Homo sapiens_hsa05162 | 0.67175282 |
| 89 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.67166837 |
| 90 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.64694625 |
| 91 | Asthma_Homo sapiens_hsa05310 | 0.64197070 |
| 92 | Bile secretion_Homo sapiens_hsa04976 | 0.63468229 |
| 93 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.63073911 |
| 94 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.62574427 |
| 95 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.60426667 |
| 96 | Hepatitis C_Homo sapiens_hsa05160 | 0.59805871 |
| 97 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.59763402 |
| 98 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.57708710 |
| 99 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.57417935 |
| 100 | Tuberculosis_Homo sapiens_hsa05152 | 0.56322278 |
| 101 | Salmonella infection_Homo sapiens_hsa05132 | 0.56188606 |
| 102 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.55921773 |
| 103 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.54845018 |
| 104 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.54660592 |
| 105 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.54016252 |
| 106 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.51965765 |
| 107 | Metabolic pathways_Homo sapiens_hsa01100 | 0.50083585 |
| 108 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.49539423 |
| 109 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.49057287 |
| 110 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.48987659 |
| 111 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.48565790 |
| 112 | Phagosome_Homo sapiens_hsa04145 | 0.46581661 |
| 113 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.46125012 |
| 114 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.45752147 |
| 115 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.45148328 |
| 116 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.43058757 |
| 117 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40796945 |
| 118 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.40431318 |
| 119 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.40415247 |
| 120 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.40009980 |
| 121 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.39900817 |
| 122 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.39687438 |
| 123 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.39627347 |
| 124 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.39489290 |
| 125 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.38375871 |
| 126 | Malaria_Homo sapiens_hsa05144 | 0.38178861 |
| 127 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.34795464 |
| 128 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.34204160 |

