ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore organization (GO:0006999)	5.79442759
2	histamine transport (GO:0051608)	5.55063823
3	resolution of meiotic recombination intermediates (GO:0000712)	5.32274297
4	nuclear pore complex assembly (GO:0051292)	5.29221063
5	meiotic chromosome segregation (GO:0045132)	4.91478593
6	synapsis (GO:0007129)	4.76393210
7	rRNA methylation (GO:0031167)	4.62532939
8	maturation of 5.8S rRNA (GO:0000460)	4.57938328
9	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	4.56807638
10	DNA replication checkpoint (GO:0000076)	4.44078614
11	rRNA modification (GO:0000154)	4.43156781
12	terpenoid biosynthetic process (GO:0016114)	4.39416860
13	pore complex assembly (GO:0046931)	4.29362216
14	proteasome assembly (GO:0043248)	4.12142239
15	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.96505292
16	regulation of translational fidelity (GO:0006450)	3.75503933
17	positive regulation of histone H3-K4 methylation (GO:0051571)	3.67511280
18	protein K6-linked ubiquitination (GO:0085020)	3.66766958
19	microtubule depolymerization (GO:0007019)	3.66293330
20	behavioral response to nicotine (GO:0035095)	3.63179559
21	regulation of histone H3-K4 methylation (GO:0051569)	3.59598909
22	isoprenoid biosynthetic process (GO:0008299)	3.51497169
23	diterpenoid biosynthetic process (GO:0016102)	3.47912939
24	proline biosynthetic process (GO:0006561)	3.45202973
25	DNA deamination (GO:0045006)	3.44726881
26	DNA double-strand break processing (GO:0000729)	3.44183187
27	purine nucleobase biosynthetic process (GO:0009113)	3.43612015
28	oxidative phosphorylation (GO:0006119)	3.34422071
29	azole transport (GO:0045117)	3.29033818
30	regulation of meiosis I (GO:0060631)	3.28966686
31	detection of chemical stimulus involved in sensory perception (GO:0050907)	3.26833464
32	mitotic nuclear envelope disassembly (GO:0007077)	3.25843455
33	tRNA aminoacylation for protein translation (GO:0006418)	3.24697333
34	DNA catabolic process, exonucleolytic (GO:0000738)	3.21646760
35	ribonucleoprotein complex disassembly (GO:0032988)	3.20335592
36	vitamin A metabolic process (GO:0006776)	3.17297215
37	mitochondrial RNA metabolic process (GO:0000959)	3.16636051
38	negative regulation of thymocyte apoptotic process (GO:0070244)	3.13513949
39	organic cation transport (GO:0015695)	3.13188193
40	amino acid activation (GO:0043038)	3.12526724
41	tRNA aminoacylation (GO:0043039)	3.12526724
42	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.08340079
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.07413675
44	exogenous drug catabolic process (GO:0042738)	3.03016045
45	drug transmembrane transport (GO:0006855)	3.01850620
46	reciprocal DNA recombination (GO:0035825)	3.00324197
47	reciprocal meiotic recombination (GO:0007131)	3.00324197
48	rRNA catabolic process (GO:0016075)	2.98483957
49	sensory perception of smell (GO:0007608)	2.96995653
50	ribosome assembly (GO:0042255)	2.96880515
51	pseudouridine synthesis (GO:0001522)	2.95182600
52	nuclear envelope disassembly (GO:0051081)	2.93467030
53	membrane disassembly (GO:0030397)	2.93467030
54	fatty acid elongation (GO:0030497)	2.90288099
55	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.89832422
56	isotype switching (GO:0045190)	2.89832422
57	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.89832422
58	mitochondrial DNA replication (GO:0006264)	2.88958217
59	ATP synthesis coupled proton transport (GO:0015986)	2.88601859
60	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.88601859
61	aspartate family amino acid catabolic process (GO:0009068)	2.87465116
62	gas transport (GO:0015669)	2.86858865
63	aspartate family amino acid biosynthetic process (GO:0009067)	2.85299949
64	chromosome organization involved in meiosis (GO:0070192)	2.84937969
65	transcription from mitochondrial promoter (GO:0006390)	2.84748740
66	male meiosis (GO:0007140)	2.84225646
67	positive regulation of protein homodimerization activity (GO:0090073)	2.81833802
68	Peyers patch development (GO:0048541)	2.80196641
69	mucosal-associated lymphoid tissue development (GO:0048537)	2.80196641
70	positive regulation of B cell differentiation (GO:0045579)	2.76815718
71	regulation of translational elongation (GO:0006448)	2.76385838
72	regulation of penile erection (GO:0060405)	2.75158204
73	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.74872905
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.71579142
75	mismatch repair (GO:0006298)	2.71438698
76	nucleobase biosynthetic process (GO:0046112)	2.67166051
77	methionine biosynthetic process (GO:0009086)	2.65802475
78	oxygen transport (GO:0015671)	2.65434955
79	histone H2A monoubiquitination (GO:0035518)	2.65377568
80	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.64217561
81	ubiquinone biosynthetic process (GO:0006744)	2.63246957
82	neurotransmitter biosynthetic process (GO:0042136)	2.58152381
83	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.58096781
84	intra-S DNA damage checkpoint (GO:0031573)	2.55906055
85	organelle disassembly (GO:1903008)	2.55691103
86	regulation of centriole replication (GO:0046599)	2.54397802
87	positive regulation of glycolytic process (GO:0045821)	2.53635180
88	erythrocyte maturation (GO:0043249)	2.53590004
89	ribosome biogenesis (GO:0042254)	2.52862990
90	tRNA modification (GO:0006400)	2.52724966
91	kynurenine metabolic process (GO:0070189)	2.51706687
92	ubiquinone metabolic process (GO:0006743)	2.51219431
93	positive regulation of meiosis (GO:0045836)	2.50793649
94	viral mRNA export from host cell nucleus (GO:0046784)	2.48852333
95	regulation of immunoglobulin secretion (GO:0051023)	2.48622914
96	DNA methylation involved in gamete generation (GO:0043046)	2.48216490
97	valine metabolic process (GO:0006573)	2.46818955
98	formation of translation preinitiation complex (GO:0001731)	2.45792101
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.45786521
100	termination of RNA polymerase III transcription (GO:0006386)	2.45786521

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.78250626
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.65086311
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.41499507
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.35799040
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.02448269
6	ELK1_19687146_ChIP-ChIP_HELA_Human	3.02326923
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.95620649
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.80752472
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.71405738
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.55171327
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.38102641
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.38057549
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35237316
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.22080629
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.20869987
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.09296906
17	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.07293621
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.04396033
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02947838
20	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.01033348
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00042503
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.99525817
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.96118231
24	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.93797171
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93542715
26	VDR_22108803_ChIP-Seq_LS180_Human	1.89589159
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86844263
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.85879918
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84446637
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.83783620
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.83695504
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.79085900
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74733870
34	EWS_26573619_Chip-Seq_HEK293_Human	1.70677412
35	NCOR1_26117541_ChIP-Seq_K562_Human	1.69694410
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.67031240
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65343380
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.62689430
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.62530992
40	GATA1_19941826_ChIP-Seq_K562_Human	1.56928527
41	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.54528982
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.52728006
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.42755079
44	GATA2_19941826_ChIP-Seq_K562_Human	1.42512853
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.41497807
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41112953
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39842004
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36503241
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.36410297
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35461558
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30674227
52	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.30085849
53	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.29748339
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.27993721
55	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.26103677
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25315818
57	SPI1_23127762_ChIP-Seq_K562_Human	1.24169548
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.23495249
59	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.23214796
60	EZH2_22144423_ChIP-Seq_EOC_Human	1.22917534
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.22629748
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21164739
63	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.19036770
64	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.18750115
65	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.18406272
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.18155874
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17456263
68	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14749992
69	AR_20517297_ChIP-Seq_VCAP_Human	1.14329719
70	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.12816978
71	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.10517223
72	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10261920
73	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.09896093
74	PHF8_20622853_ChIP-Seq_HELA_Human	1.08981057
75	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06530168
76	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.05596432
77	GATA1_22025678_ChIP-Seq_K562_Human	1.04825666
78	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.03909289
79	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03158106
80	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02654983
81	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.02511705
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01936774
83	NFYB_21822215_ChIP-Seq_K562_Human	1.01291554
84	JUN_21703547_ChIP-Seq_K562_Human	0.98734287
85	CIITA_25753668_ChIP-Seq_RAJI_Human	0.98234295
86	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.94521234
87	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.94363792
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93389522
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92845454
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92303078
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92127085
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92127085
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90464350
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.90250064
95	AR_21909140_ChIP-Seq_LNCAP_Human	0.89430298
96	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.89400720
97	GATA3_26560356_Chip-Seq_TH1_Human	0.87928936
98	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.87777895
99	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.86847674
100	NFYA_21822215_ChIP-Seq_K562_Human	0.86675046

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	5.47021642
2	MP0004147_increased_porphyrin_level	4.00626298
3	MP0003806_abnormal_nucleotide_metabolis	3.03364176
4	MP0003693_abnormal_embryo_hatching	3.02075997
5	MP0005646_abnormal_pituitary_gland	2.94227191
6	MP0000372_irregular_coat_pigmentation	2.92815012
7	MP0000678_abnormal_parathyroid_gland	2.87131616
8	MP0004957_abnormal_blastocyst_morpholog	2.77851985
9	MP0003718_maternal_effect	2.66637412
10	MP0003786_premature_aging	2.50701315
11	MP0006035_abnormal_mitochondrial_morpho	2.47385282
12	MP0006036_abnormal_mitochondrial_physio	2.32146404
13	MP0003646_muscle_fatigue	2.29746540
14	MP0008058_abnormal_DNA_repair	2.28901793
15	MP0008995_early_reproductive_senescence	2.22354034
16	MP0004084_abnormal_cardiac_muscle	2.15029102
17	MP0005167_abnormal_blood-brain_barrier	2.09163799
18	MP0008007_abnormal_cellular_replicative	2.00603576
19	MP0002837_dystrophic_cardiac_calcinosis	1.91761178
20	MP0008872_abnormal_physiological_respon	1.91648288
21	MP0006292_abnormal_olfactory_placode	1.85660166
22	MP0001661_extended_life_span	1.83242877
23	MP0008877_abnormal_DNA_methylation	1.81265048
24	MP0008775_abnormal_heart_ventricle	1.81177316
25	MP0002132_abnormal_respiratory_system	1.78471403
26	MP0003111_abnormal_nucleus_morphology	1.75120895
27	MP0002139_abnormal_hepatobiliary_system	1.74095413
28	MP0005410_abnormal_fertilization	1.73387487
29	MP0005083_abnormal_biliary_tract	1.71563778
30	MP0008932_abnormal_embryonic_tissue	1.71323042
31	MP0006276_abnormal_autonomic_nervous	1.66221437
32	MP0010094_abnormal_chromosome_stability	1.63881136
33	MP0005084_abnormal_gallbladder_morpholo	1.60233429
34	MP0008004_abnormal_stomach_pH	1.49036249
35	MP0002160_abnormal_reproductive_system	1.45403945
36	MP0003656_abnormal_erythrocyte_physiolo	1.45188622
37	MP0003045_fibrosis	1.43746127
38	MP0004145_abnormal_muscle_electrophysio	1.38765086
39	MP0001727_abnormal_embryo_implantation	1.36438215
40	MP0005636_abnormal_mineral_homeostasis	1.34068714
41	MP0005332_abnormal_amino_acid	1.28997066
42	MP0009333_abnormal_splenocyte_physiolog	1.28829276
43	MP0004215_abnormal_myocardial_fiber	1.26342723
44	MP0005187_abnormal_penis_morphology	1.25061190
45	MP0003186_abnormal_redox_activity	1.24002321
46	MP0005464_abnormal_platelet_physiology	1.21210951
47	MP0001873_stomach_inflammation	1.19131328
48	MP0003077_abnormal_cell_cycle	1.17811720
49	MP0002102_abnormal_ear_morphology	1.17252025
50	MP0008875_abnormal_xenobiotic_pharmacok	1.17136994
51	MP0001929_abnormal_gametogenesis	1.15253465
52	MP0005389_reproductive_system_phenotype	1.14107921
53	MP0005645_abnormal_hypothalamus_physiol	1.12786895
54	MP0001529_abnormal_vocalization	1.02801110
55	MP0001440_abnormal_grooming_behavior	1.01062776
56	MP0002210_abnormal_sex_determination	0.98602985
57	MP0003698_abnormal_male_reproductive	0.96469592
58	MP0000427_abnormal_hair_cycle	0.96454912
59	MP0010329_abnormal_lipoprotein_level	0.95191553
60	MP0001919_abnormal_reproductive_system	0.95075724
61	MP0004043_abnormal_pH_regulation	0.94905222
62	MP0000647_abnormal_sebaceous_gland	0.93732549
63	MP0002282_abnormal_trachea_morphology	0.92465400
64	MP0005085_abnormal_gallbladder_physiolo	0.91964780
65	MP0005360_urolithiasis	0.91108588
66	MP0004782_abnormal_surfactant_physiolog	0.90134040
67	MP0003959_abnormal_lean_body	0.88721977
68	MP0004036_abnormal_muscle_relaxation	0.84347904
69	MP0004019_abnormal_vitamin_homeostasis	0.83691002
70	MP0005319_abnormal_enzyme/_coenzyme	0.80904943
71	MP0004233_abnormal_muscle_weight	0.79454539
72	MP0000653_abnormal_sex_gland	0.78456073
73	MP0005535_abnormal_body_temperature	0.78076862
74	MP0001835_abnormal_antigen_presentation	0.77257698
75	MP0001730_embryonic_growth_arrest	0.77030792
76	MP0001881_abnormal_mammary_gland	0.75380949
77	MP0005266_abnormal_metabolism	0.74043372
78	MP0005395_other_phenotype	0.70548465
79	MP0001968_abnormal_touch/_nociception	0.70390495
80	MP0001697_abnormal_embryo_size	0.70256248
81	MP0001764_abnormal_homeostasis	0.69230725
82	MP0004808_abnormal_hematopoietic_stem	0.68846422
83	MP0009764_decreased_sensitivity_to	0.68375056
84	MP0000681_abnormal_thyroid_gland	0.67269219
85	MP0001119_abnormal_female_reproductive	0.66588812
86	MP0000631_abnormal_neuroendocrine_gland	0.66507683
87	MP0000358_abnormal_cell_content/	0.65879576
88	MP0003300_gastrointestinal_ulcer	0.64448031
89	MP0001664_abnormal_digestion	0.64429790
90	MP0001145_abnormal_male_reproductive	0.64056168
91	MP0005408_hypopigmentation	0.63587154
92	MP0003011_delayed_dark_adaptation	0.63405800
93	MP0001672_abnormal_embryogenesis/_devel	0.62419211
94	MP0005380_embryogenesis_phenotype	0.62419211
95	MP0005397_hematopoietic_system_phenotyp	0.61578343
96	MP0001545_abnormal_hematopoietic_system	0.61578343
97	MP0002722_abnormal_immune_system	0.61330861
98	MP0001293_anophthalmia	0.60997105
99	MP0000604_amyloidosis	0.59557190
100	MP0000230_abnormal_systemic_arterial	0.58584552

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Truncus arteriosus (HP:0001660)	3.92706974
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.78280241
3	Hypoplasia of the fovea (HP:0007750)	3.78280241
4	Unilateral renal agenesis (HP:0000122)	3.59918231
5	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.49668047
6	Abnormality of the fovea (HP:0000493)	3.39797686
7	Stomatitis (HP:0010280)	3.32161958
8	Progressive inability to walk (HP:0002505)	3.29870787
9	Homocystinuria (HP:0002156)	3.25761278
10	Abnormality of homocysteine metabolism (HP:0010919)	3.25761278
11	Hyperthyroidism (HP:0000836)	2.99776089
12	Decreased central vision (HP:0007663)	2.99715444
13	Methylmalonic acidemia (HP:0002912)	2.92557559
14	Abnormal hemoglobin (HP:0011902)	2.86170877
15	Autoimmune hemolytic anemia (HP:0001890)	2.85060498
16	CNS hypomyelination (HP:0003429)	2.70459414
17	Birth length less than 3rd percentile (HP:0003561)	2.67466647
18	Conjugated hyperbilirubinemia (HP:0002908)	2.66706252
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.61663912
20	Cholecystitis (HP:0001082)	2.60643672
21	Abnormal gallbladder physiology (HP:0012438)	2.60643672
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.58802086
23	Tinnitus (HP:0000360)	2.57924848
24	Submucous cleft hard palate (HP:0000176)	2.42426813
25	Bilateral microphthalmos (HP:0007633)	2.34361883
26	Abnormal spermatogenesis (HP:0008669)	2.34306466
27	3-Methylglutaconic aciduria (HP:0003535)	2.33524205
28	Palpitations (HP:0001962)	2.31408953
29	Poikilocytosis (HP:0004447)	2.29260486
30	Autoimmune thrombocytopenia (HP:0001973)	2.26689537
31	Acute encephalopathy (HP:0006846)	2.25849561
32	Abnormality of T cell physiology (HP:0011840)	2.25635879
33	Entropion (HP:0000621)	2.22444259
34	Methylmalonic aciduria (HP:0012120)	2.22329341
35	Bowel incontinence (HP:0002607)	2.21903871
36	Duplicated collecting system (HP:0000081)	2.21809604
37	Reticulocytosis (HP:0001923)	2.20224248
38	Severe combined immunodeficiency (HP:0004430)	2.19995091
39	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.17906534
40	Ileus (HP:0002595)	2.17064640
41	Central scotoma (HP:0000603)	2.16599725
42	Abnormal large intestine physiology (HP:0012700)	2.15974541
43	Acute necrotizing encephalopathy (HP:0006965)	2.15232328
44	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.14829602
45	Abnormality of the pons (HP:0007361)	2.13592629
46	Abnormality of transition element cation homeostasis (HP:0011030)	2.12916120
47	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.10429719
48	Mesangial abnormality (HP:0001966)	2.10370672
49	Abnormal mitochondria in muscle tissue (HP:0008316)	2.09431728
50	Symptomatic seizures (HP:0011145)	2.09250680
51	Chromsome breakage (HP:0040012)	2.08528039
52	Increased hepatocellular lipid droplets (HP:0006565)	2.06464105
53	Widely patent fontanelles and sutures (HP:0004492)	2.05623285
54	Upper limb muscle weakness (HP:0003484)	2.04817373
55	Abnormality of the renal collecting system (HP:0004742)	2.03962694
56	Lipid accumulation in hepatocytes (HP:0006561)	2.00894910
57	Polycythemia (HP:0001901)	2.00806518
58	Abnormality of vitamin B metabolism (HP:0004340)	2.00452561
59	Abnormality of the right ventricle (HP:0001707)	1.99437122
60	Abnormality of the renal cortex (HP:0011035)	1.97964499
61	Hyperbilirubinemia (HP:0002904)	1.97213491
62	Progressive macrocephaly (HP:0004481)	1.96628434
63	Concave nail (HP:0001598)	1.95992571
64	Abnormality of serum amino acid levels (HP:0003112)	1.95729615
65	Aplasia/Hypoplasia of the macula (HP:0008059)	1.94933895
66	Granulocytopenia (HP:0001913)	1.93850576
67	Nausea (HP:0002018)	1.93771485
68	Myelodysplasia (HP:0002863)	1.93373721
69	Increased IgM level (HP:0003496)	1.92934850
70	Increased CSF lactate (HP:0002490)	1.92874927
71	Cortical dysplasia (HP:0002539)	1.91240660
72	Attenuation of retinal blood vessels (HP:0007843)	1.90739992
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.90615619
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.90615619
75	Abnormal protein glycosylation (HP:0012346)	1.90615619
76	Abnormal glycosylation (HP:0012345)	1.90615619
77	Combined immunodeficiency (HP:0005387)	1.90581548
78	Type II lissencephaly (HP:0007260)	1.90539257
79	Type I transferrin isoform profile (HP:0003642)	1.89066437
80	Abnormality of B cell number (HP:0010975)	1.87362324
81	Fused cervical vertebrae (HP:0002949)	1.86628461
82	Abnormality of cochlea (HP:0000375)	1.86005986
83	Seborrheic dermatitis (HP:0001051)	1.84769641
84	Abnormality of the tricuspid valve (HP:0001702)	1.83695877
85	Hypochromic microcytic anemia (HP:0004840)	1.83633421
86	Redundant skin (HP:0001582)	1.83293385
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.82770627
88	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.81709292
89	Increased serum lactate (HP:0002151)	1.81425539
90	Pancreatic cysts (HP:0001737)	1.80377335
91	Ankyloglossia (HP:0010296)	1.79296675
92	Hypoplasia of the uterus (HP:0000013)	1.78741480
93	Congenital, generalized hypertrichosis (HP:0004540)	1.77818625
94	Spastic paraparesis (HP:0002313)	1.77279043
95	Hypertensive crisis (HP:0100735)	1.76359156
96	IgG deficiency (HP:0004315)	1.75454623
97	Ureteral duplication (HP:0000073)	1.75444934
98	Abnormality of reticulocytes (HP:0004312)	1.74715494
99	Lissencephaly (HP:0001339)	1.74674228
100	Inability to walk (HP:0002540)	1.74416950

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK4	5.76066058
2	BMPR2	3.93544993
3	EIF2AK3	3.56956352
4	EIF2AK1	3.31425774
5	NUAK1	3.03586751
6	TLK1	2.74960946
7	ZAK	2.63302484
8	TTK	2.48697305
9	TAOK3	2.32359108
10	EEF2K	2.28519903
11	NEK1	2.23793570
12	TRPM7	2.21791762
13	RAF1	1.91837872
14	MAPKAPK3	1.87400573
15	MST4	1.85925842
16	PIK3CG	1.77423496
17	NTRK3	1.76099625
18	NEK2	1.71502208
19	SRPK1	1.62614811
20	CLK1	1.55823081
21	PINK1	1.53354947
22	MAPKAPK5	1.50455624
23	PLK4	1.45716954
24	TRIM28	1.42049413
25	TIE1	1.36399288
26	STK16	1.34761268
27	BUB1	1.34071156
28	ADRBK2	1.32358098
29	PLK3	1.32219559
30	MAP3K4	1.30147714
31	TEC	1.25013506
32	RPS6KB2	1.22273209
33	DAPK2	1.19229528
34	BRSK2	1.17337068
35	CHEK2	1.14427916
36	IRAK1	1.14417200
37	KSR2	1.13942786
38	CCNB1	1.13505509
39	FRK	1.11389685
40	STK3	1.08318114
41	SCYL2	1.05082710
42	RPS6KA5	1.04098600
43	TSSK6	1.04009877
44	MAP3K2	0.98068718
45	TNIK	0.97524867
46	NME1	0.93925290
47	WNK4	0.90249392
48	EIF2AK2	0.90204599
49	VRK1	0.87834913
50	BTK	0.87081627
51	MATK	0.83948278
52	TBK1	0.81000350
53	BCR	0.80205203
54	CDC7	0.77749136
55	ERBB2	0.77691175
56	SYK	0.76018568
57	ATR	0.67247397
58	WEE1	0.64571340
59	PIK3CA	0.62413926
60	SIK3	0.57286251
61	PLK1	0.55890460
62	JAK2	0.53300209
63	MARK3	0.52966684
64	MAP2K7	0.51570108
65	PTK2B	0.50653984
66	ILK	0.50280454
67	MAPK13	0.49369525
68	FES	0.46635461
69	GRK1	0.46289958
70	VRK2	0.43829112
71	ATM	0.43546582
72	MAP2K1	0.40688102
73	OXSR1	0.40347733
74	WNK3	0.40035930
75	PRKAA1	0.39387275
76	IKBKB	0.35404880
77	BMX	0.34920812
78	PBK	0.33141065
79	IRAK4	0.32637489
80	MKNK1	0.32146039
81	PRKACG	0.31978020
82	BMPR1B	0.31967737
83	KSR1	0.31220055
84	NME2	0.30394213
85	CDK1	0.29338853
86	PAK1	0.29271341
87	PRKAA2	0.28250495
88	AURKA	0.28064364
89	ALK	0.27704296
90	CSNK2A1	0.26992806
91	AURKB	0.26515791
92	CHEK1	0.26318220
93	ICK	0.25186076
94	CSNK2A2	0.24556062
95	CDK2	0.24037011
96	JAK3	0.23441603
97	EPHA3	0.22895570
98	EPHB1	0.21754471
99	STK4	0.21320397
100	PLK2	0.21073221

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.85271048
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.38155623
3	One carbon pool by folate_Homo sapiens_hsa00670	3.32377853
4	Olfactory transduction_Homo sapiens_hsa04740	3.30380268
5	Selenocompound metabolism_Homo sapiens_hsa00450	3.29832040
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.81266255
7	Homologous recombination_Homo sapiens_hsa03440	2.79264698
8	Mismatch repair_Homo sapiens_hsa03430	2.67664148
9	Proteasome_Homo sapiens_hsa03050	2.46503116
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.26181941
11	RNA polymerase_Homo sapiens_hsa03020	2.20296919
12	RNA transport_Homo sapiens_hsa03013	2.12696835
13	Butanoate metabolism_Homo sapiens_hsa00650	2.05998450
14	RNA degradation_Homo sapiens_hsa03018	2.01337243
15	Spliceosome_Homo sapiens_hsa03040	1.88624550
16	DNA replication_Homo sapiens_hsa03030	1.88205224
17	Parkinsons disease_Homo sapiens_hsa05012	1.80986923
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.79208186
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.75495262
20	Basal transcription factors_Homo sapiens_hsa03022	1.74678137
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.61079027
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59514903
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.51168768
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50355513
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.47190797
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.45272068
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.45069153
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36446936
29	Fatty acid elongation_Homo sapiens_hsa00062	1.36335439
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31368011
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29931248
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28060592
33	Purine metabolism_Homo sapiens_hsa00230	1.27871884
34	Caffeine metabolism_Homo sapiens_hsa00232	1.21830190
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.20958495
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.20524928
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.20502308
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.17995028
39	Arginine biosynthesis_Homo sapiens_hsa00220	1.16841905
40	Phototransduction_Homo sapiens_hsa04744	1.14974164
41	Protein export_Homo sapiens_hsa03060	1.13378112
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.09807487
43	Propanoate metabolism_Homo sapiens_hsa00640	1.08133887
44	Glutathione metabolism_Homo sapiens_hsa00480	1.02755977
45	Huntingtons disease_Homo sapiens_hsa05016	0.97986067
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.92989590
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.90732330
48	Sulfur metabolism_Homo sapiens_hsa00920	0.89825156
49	Base excision repair_Homo sapiens_hsa03410	0.89198415
50	Alzheimers disease_Homo sapiens_hsa05010	0.87040391
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85178206
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83332387
53	Cell cycle_Homo sapiens_hsa04110	0.82756947
54	Ribosome_Homo sapiens_hsa03010	0.79165322
55	Asthma_Homo sapiens_hsa05310	0.78135773
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75452049
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.73120629
58	Retinol metabolism_Homo sapiens_hsa00830	0.71239625
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.71168682
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69009416
61	Carbon metabolism_Homo sapiens_hsa01200	0.67770469
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66984769
63	Metabolic pathways_Homo sapiens_hsa01100	0.66681754
64	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66185855
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.65392892
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60679429
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.59107109
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55844563
69	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.53937058
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53520501
71	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.53092121
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50389727
73	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50178166
74	Peroxisome_Homo sapiens_hsa04146	0.49301918
75	Alcoholism_Homo sapiens_hsa05034	0.48875141
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48857312
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.45990198
78	Pentose phosphate pathway_Homo sapiens_hsa00030	0.45527440
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.45478345
80	Sulfur relay system_Homo sapiens_hsa04122	0.44216014
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42454011
82	Long-term depression_Homo sapiens_hsa04730	0.38358099
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37226893
84	Allograft rejection_Homo sapiens_hsa05330	0.36249739
85	Serotonergic synapse_Homo sapiens_hsa04726	0.36145707
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35087673
87	Oocyte meiosis_Homo sapiens_hsa04114	0.34016057
88	Choline metabolism in cancer_Homo sapiens_hsa05231	0.32690715
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32548733
90	Mineral absorption_Homo sapiens_hsa04978	0.31476590
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31162425
92	Nicotine addiction_Homo sapiens_hsa05033	0.30426838
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30420979
94	Viral carcinogenesis_Homo sapiens_hsa05203	0.28927087
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28273902
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26903475
97	Morphine addiction_Homo sapiens_hsa05032	0.25842414
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25696560
99	Tryptophan metabolism_Homo sapiens_hsa00380	0.25204862
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.24411995

RBM48P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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