RBM4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)7.75564782
2attachment of spindle microtubules to kinetochore (GO:0008608)7.52972453
3negative regulation of translation, ncRNA-mediated (GO:0040033)7.07298078
4regulation of translation, ncRNA-mediated (GO:0045974)7.07298078
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)7.07298078
6N-acetylneuraminate metabolic process (GO:0006054)6.64150741
7amino sugar catabolic process (GO:0046348)6.54525721
8production of molecular mediator involved in inflammatory response (GO:0002532)5.76534893
9GMP metabolic process (GO:0046037)5.28834425
10mitotic metaphase plate congression (GO:0007080)5.25325387
11DNA deamination (GO:0045006)5.15919600
12negative regulation of myotube differentiation (GO:0010832)5.11960433
13negative regulation of transcription by competitive promoter binding (GO:0010944)5.10078529
14nuclear pore organization (GO:0006999)4.85946468
15facial nerve structural organization (GO:0021612)4.63072624
16androgen biosynthetic process (GO:0006702)4.52251598
17GDP-mannose metabolic process (GO:0019673)4.50893208
18respiratory chain complex IV assembly (GO:0008535)4.49472763
19postsynaptic membrane organization (GO:0001941)4.37247811
20mannosylation (GO:0097502)4.35046973
21microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.28629015
22microtubule anchoring (GO:0034453)4.28386229
23metaphase plate congression (GO:0051310)4.23768974
24motile cilium assembly (GO:0044458)4.20184140
25nerve growth factor signaling pathway (GO:0038180)4.18735445
26dolichol-linked oligosaccharide biosynthetic process (GO:0006488)4.13069051
27DNA integration (GO:0015074)4.13050212
28lymphoid progenitor cell differentiation (GO:0002320)3.96086468
29neural tube formation (GO:0001841)3.94890803
30presynaptic membrane assembly (GO:0097105)3.93003984
31C-terminal protein lipidation (GO:0006501)3.87065462
32generation of neurons (GO:0048699)3.82236148
33regulation of type B pancreatic cell apoptotic process (GO:2000674)3.82184650
34DNA ligation (GO:0006266)3.79515223
35telomere maintenance via semi-conservative replication (GO:0032201)3.76896868
36heart process (GO:0003015)3.70592628
37heart contraction (GO:0060047)3.70592628
38cytochrome complex assembly (GO:0017004)3.65395995
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64015347
40regulation of pigment cell differentiation (GO:0050932)3.63860719
41pyrimidine nucleobase catabolic process (GO:0006208)3.62169943
42C-terminal protein amino acid modification (GO:0018410)3.61824822
43negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.61288625
44cranial nerve morphogenesis (GO:0021602)3.57311463
45DNA catabolic process, exonucleolytic (GO:0000738)3.47149969
46signal peptide processing (GO:0006465)3.45025210
47adaptation of signaling pathway (GO:0023058)3.44137152
48piRNA metabolic process (GO:0034587)3.44060336
49N-acetylglucosamine metabolic process (GO:0006044)3.43708084
50viral genome replication (GO:0019079)3.40147084
51GPI anchor biosynthetic process (GO:0006506)3.37931275
52behavioral response to nicotine (GO:0035095)3.33501455
53positive regulation of cellular amine metabolic process (GO:0033240)3.29924092
54protein K11-linked deubiquitination (GO:0035871)3.29625682
55response to folic acid (GO:0051593)3.29334609
56protein heterotetramerization (GO:0051290)3.28935162
57cranial nerve structural organization (GO:0021604)3.28693951
58histone H2A acetylation (GO:0043968)3.28521796
59telomere maintenance via recombination (GO:0000722)3.21730745
60proteasome assembly (GO:0043248)3.19679413
61mitochondrion degradation (GO:0000422)3.16329380
62glycosphingolipid biosynthetic process (GO:0006688)3.11828807
63gamma-aminobutyric acid transport (GO:0015812)3.11215601
64nephron tubule formation (GO:0072079)3.11131723
65tRNA methylation (GO:0030488)3.09308550
66presynaptic membrane organization (GO:0097090)3.07787515
67DNA dealkylation (GO:0035510)3.06976383
68DNA double-strand break processing (GO:0000729)3.06517672
69intraciliary transport (GO:0042073)3.03106038
70DNA damage response, detection of DNA damage (GO:0042769)3.02634108
71negative regulation of metanephros development (GO:0072217)2.99897755
72cerebral cortex radially oriented cell migration (GO:0021799)2.99302410
73amine catabolic process (GO:0009310)2.98131636
74cellular biogenic amine catabolic process (GO:0042402)2.98131636
75neuron cell-cell adhesion (GO:0007158)2.94776648
76developmental pigmentation (GO:0048066)2.94107068
77regulation of cilium movement (GO:0003352)2.92754523
78DNA demethylation (GO:0080111)2.91497764
79spliceosomal tri-snRNP complex assembly (GO:0000244)2.90859356
80pattern specification involved in kidney development (GO:0061004)2.88229714
81negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.86584988
82centriole assembly (GO:0098534)2.86580796
83negative regulation of heart rate (GO:0010459)2.86468960
84establishment of integrated proviral latency (GO:0075713)2.85033713
85nucleobase catabolic process (GO:0046113)2.84315748
86intra-S DNA damage checkpoint (GO:0031573)2.82831854
87endothelium development (GO:0003158)2.82520650
88neuronal action potential propagation (GO:0019227)2.82293787
89sympathetic nervous system development (GO:0048485)2.81937983
90methionine biosynthetic process (GO:0009086)2.81485921
91cAMP catabolic process (GO:0006198)2.80994845
92regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80683402
93mesonephros development (GO:0001823)2.80633033
94GPI anchor metabolic process (GO:0006505)2.80558696
95positive regulation of protein homodimerization activity (GO:0090073)2.78066380
96termination of RNA polymerase III transcription (GO:0006386)2.77031605
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.77031605
98glucosamine-containing compound metabolic process (GO:1901071)2.76660860
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75188588
100positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.74621365
101platelet dense granule organization (GO:0060155)2.74422896
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73655234
103membrane invagination (GO:0010324)2.72248823
104pteridine-containing compound biosynthetic process (GO:0042559)2.72028107
105negative regulation of telomere maintenance (GO:0032205)2.71725787
106axoneme assembly (GO:0035082)2.70535739
107nonmotile primary cilium assembly (GO:0035058)2.69411646
108lateral ventricle development (GO:0021670)2.68741982
109spinal cord motor neuron differentiation (GO:0021522)2.68567961
110cilium morphogenesis (GO:0060271)2.67651863
111imidazole-containing compound metabolic process (GO:0052803)2.66986861
112spliceosomal snRNP assembly (GO:0000387)2.66765597
113calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.66613970
114cyclic nucleotide catabolic process (GO:0009214)2.65299010
115cell differentiation involved in metanephros development (GO:0072202)2.64349124
116limb bud formation (GO:0060174)2.64023672
117mitotic recombination (GO:0006312)2.63780758
118protein localization to cilium (GO:0061512)2.62354214
119DNA replication initiation (GO:0006270)2.61824825
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.61238542
121histone mRNA metabolic process (GO:0008334)2.61049249
122DNA strand elongation involved in DNA replication (GO:0006271)2.60339223
123regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.59867999
124protein-cofactor linkage (GO:0018065)2.59853440
125phospholipid scrambling (GO:0017121)2.58104314
126urogenital system development (GO:0001655)2.58035874
127establishment of chromosome localization (GO:0051303)2.57593026
128cilium assembly (GO:0042384)2.57260086
129regulation of relaxation of muscle (GO:1901077)2.57151562
130negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.56741912
131deoxyribose phosphate biosynthetic process (GO:0046385)2.55913327
1322-deoxyribonucleotide biosynthetic process (GO:0009265)2.55913327
133melanin metabolic process (GO:0006582)2.55522260
134cilium organization (GO:0044782)2.55471356
135central nervous system neuron axonogenesis (GO:0021955)2.55191191
136ribosomal small subunit assembly (GO:0000028)2.54455971
137carbohydrate phosphorylation (GO:0046835)2.53065555
138DNA strand elongation (GO:0022616)2.52536920
139sequestering of metal ion (GO:0051238)2.51461939
140preassembly of GPI anchor in ER membrane (GO:0016254)2.50951057
141protein localization to synapse (GO:0035418)2.50665178
142sterol biosynthetic process (GO:0016126)2.50026932
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.49629763
144mesenchymal cell differentiation involved in renal system development (GO:2001012)2.49629763
145telomere maintenance via telomere lengthening (GO:0010833)2.49495903
146nephron epithelium development (GO:0072009)2.49490686
147negative regulation of meiosis (GO:0045835)2.49380161
148synaptic transmission, cholinergic (GO:0007271)2.48997920
149glial cell proliferation (GO:0014009)2.48641166
150negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48384307
151specification of organ identity (GO:0010092)2.48172189
152genitalia morphogenesis (GO:0035112)2.48019571
153neuroepithelial cell differentiation (GO:0060563)2.47552297
154establishment of viral latency (GO:0019043)2.47343219
155centriole replication (GO:0007099)2.46847028
156glandular epithelial cell differentiation (GO:0002067)2.46555727
157ubiquinone metabolic process (GO:0006743)2.45680164
158positive regulation of mitochondrial fission (GO:0090141)2.45063737
159folic acid-containing compound biosynthetic process (GO:0009396)2.44962792
160positive regulation of protein export from nucleus (GO:0046827)2.44781798
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44722464
162cullin deneddylation (GO:0010388)2.44688139
163epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44671778
164methionine metabolic process (GO:0006555)2.44517335
165SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.43716366
166protein peptidyl-prolyl isomerization (GO:0000413)2.43502241
167fucosylation (GO:0036065)2.43173023
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42979993
169deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.42678780
170aspartate family amino acid biosynthetic process (GO:0009067)2.42670165
171dendrite morphogenesis (GO:0048813)2.42074451
172protein polyglutamylation (GO:0018095)2.40991153
173regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40773639
174protein complex biogenesis (GO:0070271)2.40663540
175cholesterol biosynthetic process (GO:0006695)2.40261305
176nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40043203
177mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39689711
178peptidyl-cysteine modification (GO:0018198)2.39074320
179epithelial cilium movement (GO:0003351)2.37475994
180establishment of mitochondrion localization (GO:0051654)2.35831542
181peptidyl-histidine modification (GO:0018202)2.35789580
182histone mRNA catabolic process (GO:0071044)2.33595669
183coenzyme A metabolic process (GO:0015936)2.30013101
184regulation of development, heterochronic (GO:0040034)2.29718671
185DNA methylation involved in gamete generation (GO:0043046)2.29465915
186behavioral fear response (GO:0001662)2.28018844
187behavioral defense response (GO:0002209)2.28018844
188regulation of DNA endoreduplication (GO:0032875)2.27485505
189neuron recognition (GO:0008038)2.26873805
190synapse assembly (GO:0007416)2.26295456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.96782896
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.03206867
3ZNF274_21170338_ChIP-Seq_K562_Hela3.76237798
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.64528866
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.15166120
6GBX2_23144817_ChIP-Seq_PC3_Human2.98294393
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92046289
8VDR_22108803_ChIP-Seq_LS180_Human2.79750130
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64917824
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32852411
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28703204
12EWS_26573619_Chip-Seq_HEK293_Human2.21858005
13SCL_19346495_ChIP-Seq_HPC-7_Human2.17418303
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15799759
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02152014
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01274615
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99963607
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95713270
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93968113
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93528235
21IGF1R_20145208_ChIP-Seq_DFB_Human1.91100819
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86156533
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84656598
24P300_19829295_ChIP-Seq_ESCs_Human1.78129525
25IRF1_19129219_ChIP-ChIP_H3396_Human1.77424175
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76910809
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.75734017
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75025789
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.74911850
30TAF15_26573619_Chip-Seq_HEK293_Human1.74885797
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74642747
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71491231
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71459376
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69426708
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.69225944
36GATA1_22025678_ChIP-Seq_K562_Human1.68768606
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67380946
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.64927139
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62260220
40SMAD4_21799915_ChIP-Seq_A2780_Human1.60102067
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.60018978
42MYC_18940864_ChIP-ChIP_HL60_Human1.59925020
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59583523
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56135781
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.53980891
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50808621
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50509112
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.48286904
49E2F7_22180533_ChIP-Seq_HELA_Human1.48079499
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48060907
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.47035228
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44469189
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41879750
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41396191
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40099577
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38434216
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.37480764
58ER_23166858_ChIP-Seq_MCF-7_Human1.36700307
59CBP_20019798_ChIP-Seq_JUKART_Human1.36254992
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36254992
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35490339
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35367933
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32813922
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31857427
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.30322747
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.30173247
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28947184
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28784036
69P53_22387025_ChIP-Seq_ESCs_Mouse1.27501504
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27291576
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27291576
72REST_21632747_ChIP-Seq_MESCs_Mouse1.27175756
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27136945
74* GABP_19822575_ChIP-Seq_HepG2_Human1.26904383
75VDR_23849224_ChIP-Seq_CD4+_Human1.26443903
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25585713
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.24896180
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.24802005
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24727354
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24367900
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24058456
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21534193
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21441275
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.21006892
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.19605323
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18604655
87* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18536924
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18264815
89STAT3_23295773_ChIP-Seq_U87_Human1.18019623
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17792998
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17694528
92* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17198501
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16892603
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16782695
95AR_25329375_ChIP-Seq_VCAP_Human1.16615959
96* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14529526
97MYC_18555785_ChIP-Seq_MESCs_Mouse1.14526646
98TP53_22573176_ChIP-Seq_HFKS_Human1.13799272
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13639941
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.13447216
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13270345
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12765605
103BCAT_22108803_ChIP-Seq_LS180_Human1.12708010
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11499814
105SOX9_26525672_Chip-Seq_HEART_Mouse1.11167683
106P300_18555785_Chip-Seq_ESCs_Mouse1.10529669
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09983758
108* GATA3_21867929_ChIP-Seq_CD8_Mouse1.09856815
109NCOR_22424771_ChIP-Seq_293T_Human1.09042120
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.08202385
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.08136685
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07950403
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07142238
114ELK1_19687146_ChIP-ChIP_HELA_Human1.06145687
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05082530
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04449062
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.04301217
118IRF8_22096565_ChIP-ChIP_GC-B_Human1.03597732
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03349561
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.03346426
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02186892
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01132883
123THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00690291
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.99442164
125FUS_26573619_Chip-Seq_HEK293_Human0.99027331
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99026029
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98844880
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98811585
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98803709
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98708692
131E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98225968
132ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96814784
133RNF2_27304074_Chip-Seq_NSC_Mouse0.96572451
134KLF4_18555785_Chip-Seq_ESCs_Mouse0.96566969
135* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95751508
136JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94975557
137FOXP3_21729870_ChIP-Seq_TREG_Human0.94340749
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94004157
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.93561518
140RUNX2_22187159_ChIP-Seq_PCA_Human0.92573939
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.92554728
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.92531752
143CTCF_18555785_Chip-Seq_ESCs_Mouse0.92304475
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92257182
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92176649
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90927063
147CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90910433
148CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90909007
149SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90611352
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89624848
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.89463147
152TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89354335
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89130650
154SOX2_19829295_ChIP-Seq_ESCs_Human0.88543495
155NANOG_19829295_ChIP-Seq_ESCs_Human0.88543495
156SOX2_16153702_ChIP-ChIP_HESCs_Human0.88357901
157PU1_27457419_Chip-Seq_LIVER_Mouse0.88077439
158ZFX_18555785_Chip-Seq_ESCs_Mouse0.87671735
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87594225
160CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86055371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color4.60246004
2MP0006292_abnormal_olfactory_placode4.51180797
3MP0001188_hyperpigmentation4.40374459
4MP0003136_yellow_coat_color4.26996438
5MP0001529_abnormal_vocalization3.83147382
6MP0000015_abnormal_ear_pigmentation3.57619001
7MP0009379_abnormal_foot_pigmentation3.54651220
8MP0001986_abnormal_taste_sensitivity3.51075729
9MP0005174_abnormal_tail_pigmentation3.18542890
10MP0002876_abnormal_thyroid_physiology3.00225945
11MP0008260_abnormal_autophagy2.97174936
12MP0000372_irregular_coat_pigmentation2.74918270
13MP0004270_analgesia2.68834575
14MP0005075_abnormal_melanosome_morpholog2.28705633
15MP0003011_delayed_dark_adaptation2.16670482
16MP0003724_increased_susceptibility_to2.07646609
17MP0002638_abnormal_pupillary_reflex2.07370787
18MP0002095_abnormal_skin_pigmentation2.06871742
19MP0004381_abnormal_hair_follicle1.96179538
20MP0002751_abnormal_autonomic_nervous1.90768790
21MP0003880_abnormal_central_pattern1.87114299
22MP0008058_abnormal_DNA_repair1.86362738
23MP0001485_abnormal_pinna_reflex1.72956590
24MP0000681_abnormal_thyroid_gland1.70653764
25MP0002653_abnormal_ependyma_morphology1.66464316
26MP0001984_abnormal_olfaction1.65134621
27MP0002736_abnormal_nociception_after1.64059457
28MP0002938_white_spotting1.63230296
29MP0000678_abnormal_parathyroid_gland1.62648177
30MP0003122_maternal_imprinting1.59757195
31MP0002233_abnormal_nose_morphology1.57845293
32MP0002177_abnormal_outer_ear1.56698199
33MP0003718_maternal_effect1.53576536
34MP0004145_abnormal_muscle_electrophysio1.52405328
35MP0002734_abnormal_mechanical_nocicepti1.49681831
36MP0005379_endocrine/exocrine_gland_phen1.42884578
37MP0000631_abnormal_neuroendocrine_gland1.42750225
38MP0000778_abnormal_nervous_system1.41999245
39MP0003868_abnormal_feces_composition1.39163732
40MP0001502_abnormal_circadian_rhythm1.38137999
41MP0003763_abnormal_thymus_physiology1.35034496
42MP0003121_genomic_imprinting1.32800424
43MP0002160_abnormal_reproductive_system1.31812432
44MP0006276_abnormal_autonomic_nervous1.31019628
45MP0009745_abnormal_behavioral_response1.30447027
46MP0002735_abnormal_chemical_nociception1.30436788
47MP0009046_muscle_twitch1.29126084
48MP0003635_abnormal_synaptic_transmissio1.27677205
49MP0001944_abnormal_pancreas_morphology1.27074234
50MP0002693_abnormal_pancreas_physiology1.26253209
51MP0003806_abnormal_nucleotide_metabolis1.24894066
52MP0001486_abnormal_startle_reflex1.23047951
53MP0005171_absent_coat_pigmentation1.22886769
54MP0003183_abnormal_peptide_metabolism1.19414835
55MP0005084_abnormal_gallbladder_morpholo1.18450641
56MP0000490_abnormal_crypts_of1.18446904
57MP0003879_abnormal_hair_cell1.14723165
58MP0001835_abnormal_antigen_presentation1.14622220
59MP0008789_abnormal_olfactory_epithelium1.13645425
60MP0001186_pigmentation_phenotype1.13297724
61MP0002063_abnormal_learning/memory/cond1.12466316
62MP0003693_abnormal_embryo_hatching1.12411868
63MP0004084_abnormal_cardiac_muscle1.09719480
64MP0002075_abnormal_coat/hair_pigmentati1.09321369
65MP0000049_abnormal_middle_ear1.08950580
66MP0002184_abnormal_innervation1.08436400
67MP0000613_abnormal_salivary_gland1.07919069
68MP0002822_catalepsy1.06818126
69MP0005671_abnormal_response_to1.05126881
70MP0000566_synostosis1.04951372
71MP0005646_abnormal_pituitary_gland1.04889503
72MP0003221_abnormal_cardiomyocyte_apopto1.04386732
73MP0002572_abnormal_emotion/affect_behav1.02955854
74MP0001849_ear_inflammation1.02021869
75MP0004924_abnormal_behavior1.00414850
76MP0005386_behavior/neurological_phenoty1.00414850
77MP0003786_premature_aging0.98880845
78MP0004142_abnormal_muscle_tone0.97750989
79MP0004133_heterotaxia0.97327563
80MP0004859_abnormal_synaptic_plasticity0.97079518
81MP0003283_abnormal_digestive_organ0.95768156
82MP0008007_abnormal_cellular_replicative0.95504987
83MP0000749_muscle_degeneration0.94810196
84MP0002234_abnormal_pharynx_morphology0.94282256
85MP0001968_abnormal_touch/_nociception0.93216654
86MP0002752_abnormal_somatic_nervous0.93195125
87MP0008569_lethality_at_weaning0.93069044
88MP0002557_abnormal_social/conspecific_i0.93019847
89MP0002396_abnormal_hematopoietic_system0.92436551
90MP0003890_abnormal_embryonic-extraembry0.91360119
91MP0000371_diluted_coat_color0.91304667
92MP0002148_abnormal_hypersensitivity_rea0.90973361
93MP0003303_peritoneal_inflammation0.90504304
94MP0010386_abnormal_urinary_bladder0.90480060
95MP0005499_abnormal_olfactory_system0.90027013
96MP0005394_taste/olfaction_phenotype0.90027013
97MP0002928_abnormal_bile_duct0.89843744
98MP0004811_abnormal_neuron_physiology0.89067011
99MP0002163_abnormal_gland_morphology0.89005477
100MP0003861_abnormal_nervous_system0.88892838
101MP0002882_abnormal_neuron_morphology0.88547186
102MP0005391_vision/eye_phenotype0.88225460
103MP0003119_abnormal_digestive_system0.87654966
104MP0010094_abnormal_chromosome_stability0.87626107
105MP0006072_abnormal_retinal_apoptosis0.87364185
106MP0009785_altered_susceptibility_to0.86708663
107MP0000653_abnormal_sex_gland0.85795484
108MP0003646_muscle_fatigue0.85231317
109MP0002272_abnormal_nervous_system0.83918933
110MP0003755_abnormal_palate_morphology0.82456951
111MP0005220_abnormal_exocrine_pancreas0.82353584
112MP0000569_abnormal_digit_pigmentation0.81997173
113MP0003787_abnormal_imprinting0.81448471
114MP0006035_abnormal_mitochondrial_morpho0.81342332
115MP0002837_dystrophic_cardiac_calcinosis0.80765183
116MP0003698_abnormal_male_reproductive0.79966923
117MP0000955_abnormal_spinal_cord0.79653120
118MP0002064_seizures0.78841462
119MP0001970_abnormal_pain_threshold0.78459113
120MP0004742_abnormal_vestibular_system0.78346833
121MP0005367_renal/urinary_system_phenotyp0.78332372
122MP0000516_abnormal_urinary_system0.78332372
123MP0003828_pulmonary_edema0.77873753
124MP0000026_abnormal_inner_ear0.77533799
125MP0000465_gastrointestinal_hemorrhage0.77531875
126MP0002277_abnormal_respiratory_mucosa0.76551127
127MP0002067_abnormal_sensory_capabilities0.75945556
128MP0001145_abnormal_male_reproductive0.75674356
129MP0001286_abnormal_eye_development0.75635766
130MP0002152_abnormal_brain_morphology0.74998626
131MP0002210_abnormal_sex_determination0.74350587
132MP0005423_abnormal_somatic_nervous0.73416046
133MP0003938_abnormal_ear_development0.73329864
134MP0001929_abnormal_gametogenesis0.72958263
135MP0003385_abnormal_body_wall0.72398617
136MP0001293_anophthalmia0.72302685
137MP0005025_abnormal_response_to0.71785733
138MP0001919_abnormal_reproductive_system0.70966995
139MP0002069_abnormal_eating/drinking_beha0.70787557
140MP0001270_distended_abdomen0.70683693
141MP0005645_abnormal_hypothalamus_physiol0.70319247
142MP0005000_abnormal_immune_tolerance0.70230156
143MP0008995_early_reproductive_senescence0.70026482
144MP0002933_joint_inflammation0.69665211
145MP0004885_abnormal_endolymph0.69650922
146MP0005551_abnormal_eye_electrophysiolog0.69398280
147MP0003866_abnormal_defecation0.69092105
148MP0002420_abnormal_adaptive_immunity0.68771123
149MP0009697_abnormal_copulation0.68381368
150MP0008877_abnormal_DNA_methylation0.67861832
151MP0005389_reproductive_system_phenotype0.67829147
152MP0001819_abnormal_immune_cell0.66788916
153MP0002102_abnormal_ear_morphology0.66736514
154MP0001905_abnormal_dopamine_level0.66274564
155MP0005410_abnormal_fertilization0.65592338
156MP0005253_abnormal_eye_physiology0.64481502

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)7.84511661
2Reduced antithrombin III activity (HP:0001976)7.41754512
3Abnormal glycosylation (HP:0012345)5.53384726
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.53384726
5Abnormal protein N-linked glycosylation (HP:0012347)5.53384726
6Abnormal protein glycosylation (HP:0012346)5.53384726
7Hypothermia (HP:0002045)4.76656362
8Thyroid-stimulating hormone excess (HP:0002925)4.12682640
9Hypoplasia of the fovea (HP:0007750)3.39206569
10Aplasia/Hypoplasia of the fovea (HP:0008060)3.39206569
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.31995112
12Microvesicular hepatic steatosis (HP:0001414)3.31536144
13Cholecystitis (HP:0001082)3.24740063
14Abnormal gallbladder physiology (HP:0012438)3.24740063
15Agitation (HP:0000713)3.20856941
16Severe visual impairment (HP:0001141)3.19644631
17Attenuation of retinal blood vessels (HP:0007843)3.14295955
18Molar tooth sign on MRI (HP:0002419)3.11818900
19Abnormality of midbrain morphology (HP:0002418)3.11818900
20Shoulder girdle muscle weakness (HP:0003547)3.04041886
21Abnormality of the labia minora (HP:0012880)3.01404044
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93852021
23Fetal akinesia sequence (HP:0001989)2.91368117
24Abnormality of magnesium homeostasis (HP:0004921)2.87568413
25Muscle fiber atrophy (HP:0100295)2.87369985
26Cortical visual impairment (HP:0100704)2.86937202
27True hermaphroditism (HP:0010459)2.86460893
28Broad-based gait (HP:0002136)2.84578126
29Thoracic kyphosis (HP:0002942)2.83618053
30Nonprogressive disorder (HP:0003680)2.81943367
31Abnormality of the fovea (HP:0000493)2.77559288
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76545185
33Sex reversal (HP:0012245)2.72821179
34Abnormal sex determination (HP:0012244)2.72821179
35Rimmed vacuoles (HP:0003805)2.70274830
36Hip dysplasia (HP:0001385)2.68275786
37Medial flaring of the eyebrow (HP:0010747)2.67393120
38Atonic seizures (HP:0010819)2.67342837
39Gait imbalance (HP:0002141)2.64356789
40Capillary hemangiomas (HP:0005306)2.63609033
41Type II lissencephaly (HP:0007260)2.61906986
42Pancreatic fibrosis (HP:0100732)2.61092903
43Dry hair (HP:0011359)2.59932089
443-Methylglutaconic aciduria (HP:0003535)2.58973941
45Lower limb hyperreflexia (HP:0002395)2.57852792
46Decreased muscle mass (HP:0003199)2.53057873
47Aplasia of the musculature (HP:0100854)2.51447120
48Ocular albinism (HP:0001107)2.50630743
49Limb-girdle muscle atrophy (HP:0003797)2.50547044
50Abnormal rod and cone electroretinograms (HP:0008323)2.49640747
51Volvulus (HP:0002580)2.49589596
52Congenital primary aphakia (HP:0007707)2.48718471
53Tubulointerstitial nephritis (HP:0001970)2.48063654
54Progressive inability to walk (HP:0002505)2.47962808
55Drooling (HP:0002307)2.46282694
56Split foot (HP:0001839)2.46262080
57Lissencephaly (HP:0001339)2.43858430
58Late onset (HP:0003584)2.42803087
59Increased hepatocellular lipid droplets (HP:0006565)2.42336647
60Renal Fanconi syndrome (HP:0001994)2.40280861
61Hyperventilation (HP:0002883)2.40183067
62Aplastic anemia (HP:0001915)2.37663525
63Abnormality of the hip-girdle musculature (HP:0001445)2.37571758
64Abnormality of the musculature of the pelvis (HP:0001469)2.37571758
65Nephrogenic diabetes insipidus (HP:0009806)2.36246378
66Left ventricular hypertrophy (HP:0001712)2.34743917
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.30233820
68Cerebellar dysplasia (HP:0007033)2.28823563
69Renal cortical cysts (HP:0000803)2.28594422
70Iris hypopigmentation (HP:0007730)2.25013616
71Abnormality of the renal cortex (HP:0011035)2.24055024
72Hemiplegia (HP:0002301)2.23567846
73Absent speech (HP:0001344)2.21343250
74Nephronophthisis (HP:0000090)2.19953319
75Pendular nystagmus (HP:0012043)2.19914764
76Abnormality of secondary sexual hair (HP:0009888)2.19510340
77Abnormality of the axillary hair (HP:0100134)2.19510340
78Excessive salivation (HP:0003781)2.19506832
79Exertional dyspnea (HP:0002875)2.18872566
80Pelvic girdle muscle weakness (HP:0003749)2.18659305
81Abnormal number of erythroid precursors (HP:0012131)2.17785995
82Short tibia (HP:0005736)2.17692815
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.16987582
84Abnormality of the columella (HP:0009929)2.16498827
85Abnormal biliary tract physiology (HP:0012439)2.16071052
86Bile duct proliferation (HP:0001408)2.16071052
87Focal motor seizures (HP:0011153)2.15274841
88Pancreatic cysts (HP:0001737)2.13846834
89Methylmalonic acidemia (HP:0002912)2.13820225
90Inability to walk (HP:0002540)2.13325237
91Hyperglycinemia (HP:0002154)2.12888354
92Hepatocellular necrosis (HP:0001404)2.12383282
93Abnormality of the renal medulla (HP:0100957)2.12322052
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.12258297
95Abolished electroretinogram (ERG) (HP:0000550)2.11077998
96Restlessness (HP:0000711)2.10756659
97Abnormality of the preputium (HP:0100587)2.10013497
98Sclerocornea (HP:0000647)2.09641336
99Genital tract atresia (HP:0001827)2.09341600
100Abnormality of placental membranes (HP:0011409)2.08022890
101Amniotic constriction ring (HP:0009775)2.08022890
102Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07028759
103Polyphagia (HP:0002591)2.06727755
104Retinal dysplasia (HP:0007973)2.06108359
105Infantile muscular hypotonia (HP:0008947)2.05534730
106Occipital encephalocele (HP:0002085)2.05231057
107Prolonged partial thromboplastin time (HP:0003645)2.03951830
108Popliteal pterygium (HP:0009756)2.03344730
109Increased corneal curvature (HP:0100692)2.02703626
110Keratoconus (HP:0000563)2.02703626
111Chorioretinal atrophy (HP:0000533)2.02690863
112Cystic liver disease (HP:0006706)2.01906423
113Meckel diverticulum (HP:0002245)2.01742006
114Vaginal atresia (HP:0000148)2.01252826
115Abnormality of the ileum (HP:0001549)2.01199606
116Narrow forehead (HP:0000341)2.00712816
117Hypoplasia of the pons (HP:0012110)2.00449497
118Lipid accumulation in hepatocytes (HP:0006561)1.99518085
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.97399081
120Pachygyria (HP:0001302)1.96484603
121Hemiparesis (HP:0001269)1.96202921
122Bifid tongue (HP:0010297)1.95844773
123Hypomagnesemia (HP:0002917)1.95712353
124Abnormality of cells of the erythroid lineage (HP:0012130)1.95675104
125Dyschromatopsia (HP:0007641)1.95124260
126Colon cancer (HP:0003003)1.94740604
127Hepatic necrosis (HP:0002605)1.94651144
128Aplasia/Hypoplasia of the macula (HP:0008059)1.94370962
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.93962522
130Optic nerve hypoplasia (HP:0000609)1.93524060
131Chronic hepatic failure (HP:0100626)1.93336518
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91864849
133Median cleft lip (HP:0000161)1.90814558
134Ependymoma (HP:0002888)1.90746372
135Broad face (HP:0000283)1.90496550
136Flat occiput (HP:0005469)1.88453952
137Abnormality of DNA repair (HP:0003254)1.88396908
138Abnormality of chromosome stability (HP:0003220)1.88364395
139Congenital stationary night blindness (HP:0007642)1.87815741
140Optic disc pallor (HP:0000543)1.87645394
141Postaxial foot polydactyly (HP:0001830)1.86568151
142Poor coordination (HP:0002370)1.86352324
143Oculomotor apraxia (HP:0000657)1.86281937
144Cortical dysplasia (HP:0002539)1.86010667
145Decreased central vision (HP:0007663)1.83788984
146Abnormality of the pons (HP:0007361)1.82424959
147Abnormality of the prostate (HP:0008775)1.82310959
148Small hand (HP:0200055)1.81627440
149Postaxial hand polydactyly (HP:0001162)1.81364792
150Increased CSF lactate (HP:0002490)1.81054712
151Chromsome breakage (HP:0040012)1.80208604
152Dandy-Walker malformation (HP:0001305)1.78101551
153Abnormal hair whorl (HP:0010721)1.77754907
154Intestinal atresia (HP:0011100)1.77669282
155Reticulocytopenia (HP:0001896)1.77227615
156Aplasia/hypoplasia of the uterus (HP:0008684)1.76931869
157Acute lymphatic leukemia (HP:0006721)1.76708809
158Microcytic anemia (HP:0001935)1.76354113
159Supernumerary spleens (HP:0009799)1.76282124
160Type 2 muscle fiber atrophy (HP:0003554)1.74772140
161Abnormality of renal resorption (HP:0011038)1.74382286
162Abnormal delayed hypersensitivity skin test (HP:0002963)1.73651440
163Basal ganglia calcification (HP:0002135)1.72370076
164Clubbing of toes (HP:0100760)1.70111255
165Mitochondrial inheritance (HP:0001427)1.68341023
166Nephroblastoma (Wilms tumor) (HP:0002667)1.66670484
167Meningitis (HP:0001287)1.66495092
168Decreased circulating renin level (HP:0003351)1.66333960
169Abnormality of the thoracic spine (HP:0100711)1.66052270
170Gaze-evoked nystagmus (HP:0000640)1.65496397
171Abnormal spermatogenesis (HP:0008669)1.64351196
172Male pseudohermaphroditism (HP:0000037)1.64246362
173Patchy hypopigmentation of hair (HP:0011365)1.63440053
174Preaxial hand polydactyly (HP:0001177)1.63389332
175Progressive muscle weakness (HP:0003323)1.62320728
176Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62164379
177Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62164379
178Renal tubular dysfunction (HP:0000124)1.61104770
179Hypoplasia of the radius (HP:0002984)1.59247362
180Abnormality of the phalanges of the hallux (HP:0010057)1.59195246
181Spinal canal stenosis (HP:0003416)1.59002191
182Anencephaly (HP:0002323)1.58614086
183Recurrent cutaneous fungal infections (HP:0011370)1.57097936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK8.21301462
2NEK16.71254141
3EIF2AK35.09103415
4VRK24.49162947
5MARK13.18587576
6STK163.11947272
7NME23.08686717
8MKNK23.02111195
9NLK2.97969681
10MAPK132.82901596
11CASK2.40609050
12MAP3K42.40127325
13FRK2.24783648
14TEC2.14484658
15NUAK12.12632359
16FES2.11491155
17CAMKK22.05646449
18MAP4K22.03346144
19MKNK12.01435613
20SRPK11.89902852
21MUSK1.85440512
22EIF2AK21.84672188
23IRAK31.80331433
24BCR1.78725810
25IRAK41.73848349
26TRIM281.68262085
27TLK11.59508254
28ZAK1.58753529
29MAP2K71.57674201
30INSRR1.53536360
31PRPF4B1.44878432
32MAPK151.42106429
33STK391.40551334
34CSNK1G21.35059001
35CAMK11.32763396
36NTRK31.30862771
37EPHA31.22019750
38YES11.19317930
39VRK11.17518222
40EPHA41.17167226
41OXSR11.14353812
42BTK1.13560985
43KIT1.13055940
44FLT31.05176081
45PAK31.05130855
46STK38L1.04648963
47BCKDK1.03869178
48BUB11.02113735
49TSSK60.99652567
50PLK20.93895591
51CDK30.92485372
52PIM20.91465345
53DYRK30.89363382
54PASK0.88983577
55IRAK10.88306731
56MAPK110.83577664
57IRAK20.82911083
58PRKCE0.82417436
59CLK10.80444452
60SIK30.80182840
61PRKD20.80136983
62HIPK20.77867671
63TAOK20.77539454
64ADRBK20.75885529
65WEE10.74044613
66CDK190.69544474
67NEK20.69067416
68PRKCG0.68033620
69UHMK10.66870397
70MAPK120.63199279
71PLK30.63032994
72NME10.62349026
73MINK10.61928220
74PINK10.61386552
75WNK40.61302222
76TXK0.61004278
77MAPKAPK30.60830456
78PKN10.58538996
79AKT30.58092238
80BRSK20.57393464
81CDK80.55722644
82BMPR1B0.55430705
83MARK20.54118901
84CDC70.52685543
85BMPR20.51910682
86MAP3K50.50791886
87SIK20.50726014
88MAPKAPK50.50032674
89PAK60.49490002
90BRD40.49393602
91MAP2K40.49373943
92PIK3CG0.49083451
93PNCK0.47976927
94LYN0.47702836
95PLK40.47380094
96CAMK40.47325375
97NTRK20.47284242
98ERBB30.45214066
99MAP3K140.45172093
100PRKACB0.43288960
101LIMK10.43093427
102MAP3K60.41691968
103MAPK40.41554531
104CDK50.39948443
105DAPK10.39258728
106CDK70.38445537
107SYK0.38379162
108DYRK20.37814333
109TIE10.37767134
110CAMK2B0.37324667
111PRKCI0.36063399
112BRAF0.36004426
113WNK30.35757114
114CSNK2A10.35487718
115PLK10.35120286
116CAMK2A0.34823276
117CCNB10.34143339
118CSNK1G10.34050045
119IKBKB0.33647528
120ATR0.33391285
121PTK2B0.33122245
122ACVR1B0.32729809
123FER0.32631593
124ZAP700.31923654
125ATM0.31362343
126EIF2AK10.31085833
127DYRK1A0.30436147
128PRKD10.29668262
129TAF10.29214639
130OBSCN0.28938595
131KSR10.28618125
132CSK0.28298346
133CDK140.28228697
134SGK20.28079499
135PHKG20.27973280
136PHKG10.27973280
137MAPK90.27848357
138NEK60.26638310
139GRK10.26388434
140RAF10.26081028
141CSNK1D0.25385694
142MAP3K120.25315987
143AURKB0.25164119
144LCK0.25138270
145MAP2K60.25132442
146RPS6KA40.25011571
147PRKG20.24802245
148RPS6KA50.24209761
149CSNK1A1L0.23773208
150RIPK40.23353336
151CSNK1G30.22986212
152CSF1R0.22882836
153MATK0.22168754
154RPS6KB10.20935885
155PRKAA20.19004039

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.72779791
2DNA replication_Homo sapiens_hsa030303.35004442
3Homologous recombination_Homo sapiens_hsa034402.94748995
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.91413901
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.90187434
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.84809362
7Ribosome_Homo sapiens_hsa030102.71448028
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64851677
9N-Glycan biosynthesis_Homo sapiens_hsa005102.58531368
10Mismatch repair_Homo sapiens_hsa034302.42249447
11Fanconi anemia pathway_Homo sapiens_hsa034602.40419960
12RNA polymerase_Homo sapiens_hsa030202.23837348
13Steroid biosynthesis_Homo sapiens_hsa001002.17739486
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12901475
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.05025602
16Pyrimidine metabolism_Homo sapiens_hsa002402.02375641
17Other glycan degradation_Homo sapiens_hsa005112.00185299
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98695593
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95951443
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82983662
21Base excision repair_Homo sapiens_hsa034101.80275967
22Butanoate metabolism_Homo sapiens_hsa006501.79104130
23Purine metabolism_Homo sapiens_hsa002301.76907775
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76050671
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73254218
26Phototransduction_Homo sapiens_hsa047441.72060846
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.67613949
28Non-homologous end-joining_Homo sapiens_hsa034501.60117190
29Basal transcription factors_Homo sapiens_hsa030221.59647773
30Thyroid cancer_Homo sapiens_hsa052161.58460648
31Arachidonic acid metabolism_Homo sapiens_hsa005901.54157945
32Propanoate metabolism_Homo sapiens_hsa006401.49618836
33Nucleotide excision repair_Homo sapiens_hsa034201.49101130
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48728401
35Circadian rhythm_Homo sapiens_hsa047101.43027924
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32525105
37Spliceosome_Homo sapiens_hsa030401.32168009
38Primary immunodeficiency_Homo sapiens_hsa053401.31400207
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30545008
40Regulation of autophagy_Homo sapiens_hsa041401.29920682
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29438951
42Oocyte meiosis_Homo sapiens_hsa041141.15971228
43RNA degradation_Homo sapiens_hsa030181.14842055
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.11921434
45Sphingolipid metabolism_Homo sapiens_hsa006001.09466435
46Selenocompound metabolism_Homo sapiens_hsa004501.09200123
47Dopaminergic synapse_Homo sapiens_hsa047281.08789466
48p53 signaling pathway_Homo sapiens_hsa041151.08430034
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08281162
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08089121
51Peroxisome_Homo sapiens_hsa041461.06009465
52Taste transduction_Homo sapiens_hsa047421.04856285
53Oxidative phosphorylation_Homo sapiens_hsa001901.03407672
54Proteasome_Homo sapiens_hsa030501.01578433
55Nicotine addiction_Homo sapiens_hsa050331.01190276
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97357328
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96181804
58One carbon pool by folate_Homo sapiens_hsa006700.96036256
59Olfactory transduction_Homo sapiens_hsa047400.94508730
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93542560
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92587743
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91562357
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91304532
64Cardiac muscle contraction_Homo sapiens_hsa042600.90344550
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.90211254
66Insulin secretion_Homo sapiens_hsa049110.89235325
67Morphine addiction_Homo sapiens_hsa050320.88429868
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87195386
69Nitrogen metabolism_Homo sapiens_hsa009100.86356628
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83747263
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.82954095
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78225128
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76705233
74Measles_Homo sapiens_hsa051620.76118764
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.75444921
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73527473
77Hematopoietic cell lineage_Homo sapiens_hsa046400.72382141
78Cell cycle_Homo sapiens_hsa041100.66699606
79TGF-beta signaling pathway_Homo sapiens_hsa043500.66232316
80Fatty acid metabolism_Homo sapiens_hsa012120.65987821
81mRNA surveillance pathway_Homo sapiens_hsa030150.65773792
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65468495
83Serotonergic synapse_Homo sapiens_hsa047260.64995643
84Alcoholism_Homo sapiens_hsa050340.63886854
85Linoleic acid metabolism_Homo sapiens_hsa005910.63628543
86Axon guidance_Homo sapiens_hsa043600.62326124
87Folate biosynthesis_Homo sapiens_hsa007900.61921681
88Glutamatergic synapse_Homo sapiens_hsa047240.61828738
89Systemic lupus erythematosus_Homo sapiens_hsa053220.60054338
90Circadian entrainment_Homo sapiens_hsa047130.59624922
91Herpes simplex infection_Homo sapiens_hsa051680.58564138
92Allograft rejection_Homo sapiens_hsa053300.58194817
93Huntingtons disease_Homo sapiens_hsa050160.57615533
94Synaptic vesicle cycle_Homo sapiens_hsa047210.57071790
95Tryptophan metabolism_Homo sapiens_hsa003800.56900617
96Type I diabetes mellitus_Homo sapiens_hsa049400.55346656
97Parkinsons disease_Homo sapiens_hsa050120.54515134
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54284653
99Wnt signaling pathway_Homo sapiens_hsa043100.53742114
100Metabolic pathways_Homo sapiens_hsa011000.52578589
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52116139
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51506156
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50348957
104Asthma_Homo sapiens_hsa053100.50128578
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48730122
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48321215
107Gap junction_Homo sapiens_hsa045400.47755008
108Alzheimers disease_Homo sapiens_hsa050100.47672904
109Collecting duct acid secretion_Homo sapiens_hsa049660.46819710
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46791180
111Sulfur metabolism_Homo sapiens_hsa009200.46230717
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.46183132
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.45974639
114Renin secretion_Homo sapiens_hsa049240.44900614
115Acute myeloid leukemia_Homo sapiens_hsa052210.44477614
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44472244
117Pyruvate metabolism_Homo sapiens_hsa006200.44061709
118beta-Alanine metabolism_Homo sapiens_hsa004100.43565137
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43289168
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43113645
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43101598
122ABC transporters_Homo sapiens_hsa020100.42364862
123Glucagon signaling pathway_Homo sapiens_hsa049220.40612334
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.39289871
125Vibrio cholerae infection_Homo sapiens_hsa051100.38231386
126Glutathione metabolism_Homo sapiens_hsa004800.38170096
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38110008
128Ether lipid metabolism_Homo sapiens_hsa005650.37862176
129Hippo signaling pathway_Homo sapiens_hsa043900.37094609
130Malaria_Homo sapiens_hsa051440.36247194
131Biosynthesis of amino acids_Homo sapiens_hsa012300.34364087
132Autoimmune thyroid disease_Homo sapiens_hsa053200.34113456
133Amphetamine addiction_Homo sapiens_hsa050310.34057815
134Fatty acid biosynthesis_Homo sapiens_hsa000610.33963127
135Cocaine addiction_Homo sapiens_hsa050300.33247290
136Fatty acid elongation_Homo sapiens_hsa000620.33174386
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33047316
138Retinol metabolism_Homo sapiens_hsa008300.31006796
139Chemical carcinogenesis_Homo sapiens_hsa052040.30920426
140RNA transport_Homo sapiens_hsa030130.29723357
141Renin-angiotensin system_Homo sapiens_hsa046140.27524827
142GABAergic synapse_Homo sapiens_hsa047270.27227074
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27171834
144Vitamin digestion and absorption_Homo sapiens_hsa049770.25448732
145Sulfur relay system_Homo sapiens_hsa041220.25368739
146Calcium signaling pathway_Homo sapiens_hsa040200.25271364
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25270094
148Leishmaniasis_Homo sapiens_hsa051400.22795498

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