RBM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.42205182
2peptidyl-lysine trimethylation (GO:0018023)4.01056837
3pyrimidine nucleobase catabolic process (GO:0006208)3.91406433
4establishment of protein localization to Golgi (GO:0072600)3.90857553
5cilium or flagellum-dependent cell motility (GO:0001539)3.89652654
6activated T cell proliferation (GO:0050798)3.87607447
7protein targeting to Golgi (GO:0000042)3.75601595
8negative regulation of cell killing (GO:0031342)3.75274386
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75274386
10retrograde transport, vesicle recycling within Golgi (GO:0000301)3.63862382
11histone H3-K9 demethylation (GO:0033169)3.57410476
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44748187
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.44748187
14regulation of translation, ncRNA-mediated (GO:0045974)3.44748187
15mRNA splice site selection (GO:0006376)3.41568249
16histone H3-K4 methylation (GO:0051568)3.40541376
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28439358
18histone H3-K36 demethylation (GO:0070544)3.22366562
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.15322238
20histone lysine demethylation (GO:0070076)3.06202401
21positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.03057872
22regulation of B cell receptor signaling pathway (GO:0050855)2.98935069
23histone H2A acetylation (GO:0043968)2.97365908
24epithelial cilium movement (GO:0003351)2.96741624
25cilium movement (GO:0003341)2.93675626
26poly(A)+ mRNA export from nucleus (GO:0016973)2.93346929
27histone demethylation (GO:0016577)2.92332221
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90093084
29seminiferous tubule development (GO:0072520)2.88403890
30nucleobase catabolic process (GO:0046113)2.85090724
31protein localization to Golgi apparatus (GO:0034067)2.82788877
32regulation of pigment cell differentiation (GO:0050932)2.79366711
33definitive hemopoiesis (GO:0060216)2.78434378
34establishment of nucleus localization (GO:0040023)2.76269974
35interkinetic nuclear migration (GO:0022027)2.72801261
36mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71765916
37mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71765916
38peptidyl-lysine methylation (GO:0018022)2.69055654
39cell differentiation involved in metanephros development (GO:0072202)2.67010789
40histone lysine methylation (GO:0034968)2.66915164
41positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.63229763
42cellular extravasation (GO:0045123)2.62204598
43regulation of gamma-delta T cell activation (GO:0046643)2.61126817
44positive regulation of granulocyte differentiation (GO:0030854)2.60526308
45negative thymic T cell selection (GO:0045060)2.58765493
46protein demethylation (GO:0006482)2.57916491
47protein dealkylation (GO:0008214)2.57916491
48negative regulation of lymphocyte mediated immunity (GO:0002707)2.57139975
49cardiac chamber formation (GO:0003207)2.57008975
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.56085320
51neutrophil mediated immunity (GO:0002446)2.55260684
52regulation of gamma-delta T cell differentiation (GO:0045586)2.54518803
53axoneme assembly (GO:0035082)2.54346691
54regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53043498
55regulation of Rab GTPase activity (GO:0032313)2.52632812
56positive regulation of Rab GTPase activity (GO:0032851)2.52632812
57histone H3-K9 methylation (GO:0051567)2.52599358
58negative T cell selection (GO:0043383)2.49902175
59lymphoid progenitor cell differentiation (GO:0002320)2.48584728
60cardiac ventricle formation (GO:0003211)2.48469487
61cellular response to ethanol (GO:0071361)2.47331167
62intraciliary transport (GO:0042073)2.47050084
63nucleus localization (GO:0051647)2.44868265
64regulation of granulocyte differentiation (GO:0030852)2.44386053
65presynaptic membrane assembly (GO:0097105)2.43937956
66regulation of ARF GTPase activity (GO:0032312)2.42899023
67axonemal dynein complex assembly (GO:0070286)2.42171629
68antigen processing and presentation of endogenous antigen (GO:0019883)2.42132710
69microtubule nucleation (GO:0007020)2.39757858
70postsynaptic membrane organization (GO:0001941)2.39207874
71neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.37428423
72central nervous system neuron axonogenesis (GO:0021955)2.36598310
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36551574
74cell differentiation involved in kidney development (GO:0061005)2.34054020
75* regulation of mRNA splicing, via spliceosome (GO:0048024)2.32320805
76negative regulation of immunoglobulin mediated immune response (GO:0002890)2.32129051
77negative regulation of B cell mediated immunity (GO:0002713)2.32129051
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.31869595
79myeloid leukocyte mediated immunity (GO:0002444)2.31818545
80negative regulation of Rho protein signal transduction (GO:0035024)2.31568853
81response to muramyl dipeptide (GO:0032495)2.30914653
82protein polyglutamylation (GO:0018095)2.30073697
83modulation by symbiont of host defense response (GO:0052031)2.29949746
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29949746
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.29949746
86positive regulation by organism of defense response of other organism involved in symbiotic interact2.29949746
87modulation by symbiont of host immune response (GO:0052553)2.29949746
88positive regulation by symbiont of host defense response (GO:0052509)2.29949746
89response to interleukin-15 (GO:0070672)2.29426649
90centrosome localization (GO:0051642)2.27641373
91coronary vasculature morphogenesis (GO:0060977)2.27605708
92dentate gyrus development (GO:0021542)2.26652067
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.26316569
94positive regulation of histone H3-K4 methylation (GO:0051571)2.25308689
95cerebellar Purkinje cell differentiation (GO:0021702)2.25165879
96histone H4 deacetylation (GO:0070933)2.25047386
97Golgi to endosome transport (GO:0006895)2.24670126
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.24616356
99positive regulation of gamma-delta T cell activation (GO:0046645)2.24575409
100mesenchymal cell differentiation (GO:0048762)2.23276666
101regulation of histone H3-K27 methylation (GO:0061085)2.23087471
102microglial cell activation (GO:0001774)2.20898009
103positive regulation of cardiac muscle cell differentiation (GO:2000727)2.20335198
104histamine secretion (GO:0001821)2.20045523
105central nervous system projection neuron axonogenesis (GO:0021952)2.19662828
106positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.18928771
107mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.18928771
108cellular response to interleukin-15 (GO:0071350)2.18783504
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.17838509
110regulation of DNA endoreduplication (GO:0032875)2.17268589
111positive regulation of developmental pigmentation (GO:0048087)2.16644791
112presynaptic membrane organization (GO:0097090)2.16603422
113neuron recognition (GO:0008038)2.16042918
114ventricular system development (GO:0021591)2.14581270
115motile cilium assembly (GO:0044458)2.14227810
116protein-DNA complex disassembly (GO:0032986)2.13360437
117nucleosome disassembly (GO:0006337)2.13360437
118intra-Golgi vesicle-mediated transport (GO:0006891)2.13320826
119histone H4-K16 acetylation (GO:0043984)2.13050757
120detection of other organism (GO:0098543)2.12697149
121limb development (GO:0060173)2.12432197
122appendage development (GO:0048736)2.12432197
123cell migration in hindbrain (GO:0021535)2.11613559
124sperm motility (GO:0030317)2.11156630
125regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.11133687
126nonmotile primary cilium assembly (GO:0035058)2.11030422
127kidney mesenchyme development (GO:0072074)2.10596703
128regulation of ARF protein signal transduction (GO:0032012)2.10483199
129startle response (GO:0001964)2.09372053
130histone methylation (GO:0016571)2.08143056
131histone H3-K9 modification (GO:0061647)2.07936991
132neuron cell-cell adhesion (GO:0007158)2.07714088
133embryonic hemopoiesis (GO:0035162)2.07535052
134positive T cell selection (GO:0043368)2.04831164
135neural tube formation (GO:0001841)2.04461337
136regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.04328086
137regulation of sarcomere organization (GO:0060297)2.02716869
138negative regulation of myotube differentiation (GO:0010832)2.02703841
139cranial nerve morphogenesis (GO:0021602)2.01555473
140B cell homeostasis (GO:0001782)2.01431522
141germinal center formation (GO:0002467)2.00803650
142smooth muscle tissue development (GO:0048745)2.00595157
143regulation of telomere maintenance (GO:0032204)2.00420346
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.00266807
145pericardium development (GO:0060039)1.99855026
146mitotic sister chromatid cohesion (GO:0007064)1.99362962
147developmental pigmentation (GO:0048066)1.99340558
148limb bud formation (GO:0060174)1.98565335
149head development (GO:0060322)1.98407651
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.98218781
151specification of organ identity (GO:0010092)1.97919621
152sympathetic nervous system development (GO:0048485)1.97515119
153cerebral cortex radially oriented cell migration (GO:0021799)1.96848212
154cell proliferation in forebrain (GO:0021846)1.95614103
155face development (GO:0060324)1.95550033
156* regulation of mRNA processing (GO:0050684)1.95275135
157B cell receptor signaling pathway (GO:0050853)1.94346542
158ionotropic glutamate receptor signaling pathway (GO:0035235)1.93950343
159* regulation of RNA splicing (GO:0043484)1.93513473
160DNA demethylation (GO:0080111)1.92562889
161regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.92432400
162negative regulation of stem cell proliferation (GO:2000647)1.91145219
163somite development (GO:0061053)1.91053586
164glutamate receptor signaling pathway (GO:0007215)1.90473353
165positive regulation of protein homodimerization activity (GO:0090073)1.90333536
166histone H4-K5 acetylation (GO:0043981)1.90215785
167histone H4-K8 acetylation (GO:0043982)1.90215785
168synaptic transmission, glutamatergic (GO:0035249)1.89701701
169protein localization to synapse (GO:0035418)1.89492926
170regulation of histone H3-K4 methylation (GO:0051569)1.89105087
171inner ear receptor stereocilium organization (GO:0060122)1.88352543
172mechanosensory behavior (GO:0007638)1.87282611
173glomerulus development (GO:0032835)1.87111095
174regulation of germinal center formation (GO:0002634)1.86595959
175mesonephros development (GO:0001823)1.86573057
176negative regulation of DNA-dependent DNA replication (GO:2000104)1.86554409
177* regulation of alternative mRNA splicing, via spliceosome (GO:0000381)1.86185769
178regulation of regulatory T cell differentiation (GO:0045589)1.85434601
179positive regulation of myoblast differentiation (GO:0045663)1.85381970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.71594523
2EZH2_22144423_ChIP-Seq_EOC_Human3.61640042
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94646304
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93239446
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29396232
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23674361
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.21265273
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16901881
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11909690
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.10280942
11FUS_26573619_Chip-Seq_HEK293_Human2.07186773
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04266925
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03565991
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99301981
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98297787
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.97845329
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93673515
18EWS_26573619_Chip-Seq_HEK293_Human1.84283850
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.80217241
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79118520
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75544935
22P300_19829295_ChIP-Seq_ESCs_Human1.74381047
23DROSHA_22980978_ChIP-Seq_HELA_Human1.73293024
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.66775122
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65813211
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65460568
27TAF15_26573619_Chip-Seq_HEK293_Human1.60117949
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58369590
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56228127
30SMAD4_21799915_ChIP-Seq_A2780_Human1.56196501
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55996918
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53355736
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53286169
34IGF1R_20145208_ChIP-Seq_DFB_Human1.53029988
35ZNF274_21170338_ChIP-Seq_K562_Hela1.52496771
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52008727
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51586934
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.51194884
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49664412
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.49231215
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48424236
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48287010
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47318084
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45695300
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45695300
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44200416
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.43911857
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.43203527
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41689138
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40322259
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40322259
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39695983
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.38703804
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38034423
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35886766
56VDR_24787735_ChIP-Seq_THP-1_Human1.35854882
57TCF4_23295773_ChIP-Seq_U87_Human1.33475770
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.33441539
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33030368
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31957076
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31238506
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.29744117
63REST_21632747_ChIP-Seq_MESCs_Mouse1.29417933
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.29360983
65STAT3_23295773_ChIP-Seq_U87_Human1.29319240
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28789919
67RNF2_27304074_Chip-Seq_NSC_Mouse1.25579569
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25026575
69P53_22387025_ChIP-Seq_ESCs_Mouse1.23134945
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23098178
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23012464
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22412680
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21688209
74ER_23166858_ChIP-Seq_MCF-7_Human1.21625658
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19909626
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.17892105
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17760298
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.17478482
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16746537
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16196314
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15999188
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.14442031
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.14386439
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14308644
85CBP_20019798_ChIP-Seq_JUKART_Human1.14308644
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14183563
87AR_25329375_ChIP-Seq_VCAP_Human1.13461719
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13191906
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12932878
90AR_21572438_ChIP-Seq_LNCaP_Human1.12682662
91SCL_19346495_ChIP-Seq_HPC-7_Human1.12566742
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12151740
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12150741
94RUNX2_22187159_ChIP-Seq_PCA_Human1.11830611
95RXR_22108803_ChIP-Seq_LS180_Human1.11283903
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11055725
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.11010319
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.10825270
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.10614405
100P300_18555785_Chip-Seq_ESCs_Mouse1.09257092
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08389375
102WDR5_24793694_ChIP-Seq_LNCAP_Human1.08378727
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08209457
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07846194
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07517340
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07365034
107CIITA_25753668_ChIP-Seq_RAJI_Human1.06964845
108SOX9_26525672_Chip-Seq_HEART_Mouse1.06654314
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06363537
110TP53_16413492_ChIP-PET_HCT116_Human1.06241318
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05788240
112NMYC_18555785_Chip-Seq_ESCs_Mouse1.05267987
113* AHR_22903824_ChIP-Seq_MCF-7_Human1.04581056
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03354410
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03308591
116RUNX_20019798_ChIP-Seq_JUKART_Human1.03035940
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02691805
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.01077128
119AR_19668381_ChIP-Seq_PC3_Human1.00505059
120BCAT_22108803_ChIP-Seq_LS180_Human1.00308745
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99129228
122IRF8_27001747_Chip-Seq_BMDM_Mouse0.98932163
123* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98887828
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98576379
125* KDM2B_26808549_Chip-Seq_REH_Human0.98396653
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97994147
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97909303
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97639068
129SMRT_27268052_Chip-Seq_Bcells_Human0.94797922
130SPI1_23127762_ChIP-Seq_K562_Human0.94577874
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93671649
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93141423
133GATA3_27048872_Chip-Seq_THYMUS_Human0.92683183
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.92425761
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91624012
136IRF1_19129219_ChIP-ChIP_H3396_Human0.91429136
137SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91097087
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.88618428
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.88424403
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86259096
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85473015
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84912071
143SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84759549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.96639344
2MP0000569_abnormal_digit_pigmentation3.10504997
3MP0003122_maternal_imprinting3.00190742
4MP0001188_hyperpigmentation2.99790211
5MP0003121_genomic_imprinting2.81837943
6MP0003724_increased_susceptibility_to2.62353030
7MP0006292_abnormal_olfactory_placode2.56246183
8MP0005409_darkened_coat_color2.50552784
9MP0001986_abnormal_taste_sensitivity2.10363898
10MP0000566_synostosis2.05848322
11MP0003941_abnormal_skin_development1.93265364
12MP0008877_abnormal_DNA_methylation1.90136226
13MP0001984_abnormal_olfaction1.89946710
14MP0002822_catalepsy1.89709326
15MP0005174_abnormal_tail_pigmentation1.88168237
16MP0003303_peritoneal_inflammation1.86853923
17MP0002653_abnormal_ependyma_morphology1.80641747
18MP0001800_abnormal_humoral_immune1.70583994
19MP0001835_abnormal_antigen_presentation1.68101463
20MP0000015_abnormal_ear_pigmentation1.66606373
21MP0002938_white_spotting1.64915707
22MP0005171_absent_coat_pigmentation1.58901722
23MP0003436_decreased_susceptibility_to1.54686390
24MP0003878_abnormal_ear_physiology1.54569625
25MP0005377_hearing/vestibular/ear_phenot1.54569625
26MP0003880_abnormal_central_pattern1.54321704
27MP0005503_abnormal_tendon_morphology1.47358624
28MP0004859_abnormal_synaptic_plasticity1.44153114
29MP0005423_abnormal_somatic_nervous1.44020614
30MP0003385_abnormal_body_wall1.42750217
31MP0003172_abnormal_lysosome_physiology1.42456991
32MP0000955_abnormal_spinal_cord1.41417742
33MP0005248_abnormal_Harderian_gland1.40888520
34MP0003690_abnormal_glial_cell1.40063983
35MP0005646_abnormal_pituitary_gland1.35846263
36MP0005310_abnormal_salivary_gland1.35657054
37MP0002095_abnormal_skin_pigmentation1.34743087
38MP0003828_pulmonary_edema1.30405913
39MP0008058_abnormal_DNA_repair1.28912545
40MP0009278_abnormal_bone_marrow1.28737620
41MP0008995_early_reproductive_senescence1.26105835
42MP0002249_abnormal_larynx_morphology1.25889378
43MP0004142_abnormal_muscle_tone1.25875345
44MP0000778_abnormal_nervous_system1.25752620
45MP0004808_abnormal_hematopoietic_stem1.25158699
46MP0002419_abnormal_innate_immunity1.22653217
47MP0002396_abnormal_hematopoietic_system1.20802077
48MP0000631_abnormal_neuroendocrine_gland1.20168502
49MP0005551_abnormal_eye_electrophysiolog1.20115722
50MP0003635_abnormal_synaptic_transmissio1.18346360
51MP0005645_abnormal_hypothalamus_physiol1.17897038
52MP0004811_abnormal_neuron_physiology1.16472816
53MP0006072_abnormal_retinal_apoptosis1.15518394
54MP0002420_abnormal_adaptive_immunity1.15102221
55MP0002723_abnormal_immune_serum1.14986933
56MP0005379_endocrine/exocrine_gland_phen1.14484032
57MP0005075_abnormal_melanosome_morpholog1.14399023
58MP0001502_abnormal_circadian_rhythm1.12280954
59MP0002928_abnormal_bile_duct1.11795529
60MP0001819_abnormal_immune_cell1.11545890
61MP0001486_abnormal_startle_reflex1.11028069
62MP0001968_abnormal_touch/_nociception1.10312610
63MP0003763_abnormal_thymus_physiology1.10265306
64MP0009745_abnormal_behavioral_response1.09061478
65MP0005410_abnormal_fertilization1.08559660
66MP0001790_abnormal_immune_system1.07996625
67MP0005387_immune_system_phenotype1.07996625
68MP0004130_abnormal_muscle_cell1.06904973
69MP0003942_abnormal_urinary_system1.05790017
70MP0000678_abnormal_parathyroid_gland1.05460166
71MP0000049_abnormal_middle_ear1.05429043
72MP0001293_anophthalmia1.05074920
73MP0002177_abnormal_outer_ear1.04421140
74MP0008789_abnormal_olfactory_epithelium1.03910955
75MP0008569_lethality_at_weaning1.03736778
76MP0003123_paternal_imprinting1.03365137
77MP0003698_abnormal_male_reproductive1.03343419
78MP0002452_abnormal_antigen_presenting1.02865185
79MP0002572_abnormal_emotion/affect_behav1.01948853
80MP0005671_abnormal_response_to1.01778118
81MP0008961_abnormal_basal_metabolism1.01134349
82MP0005025_abnormal_response_to1.00570801
83MP0003632_abnormal_nervous_system0.99439393
84MP0000465_gastrointestinal_hemorrhage0.98937858
85MP0003943_abnormal_hepatobiliary_system0.98830297
86MP0004883_abnormal_blood_vessel0.98701897
87MP0002067_abnormal_sensory_capabilities0.98368848
88MP0001501_abnormal_sleep_pattern0.97822930
89MP0003935_abnormal_craniofacial_develop0.96155391
90MP0005397_hematopoietic_system_phenotyp0.96108567
91MP0001545_abnormal_hematopoietic_system0.96108567
92MP0009046_muscle_twitch0.95956226
93MP0004381_abnormal_hair_follicle0.94644189
94MP0009115_abnormal_fat_cell0.94565722
95MP0003300_gastrointestinal_ulcer0.94320429
96MP0000685_abnormal_immune_system0.94207743
97MP0002405_respiratory_system_inflammati0.94206880
98MP0002557_abnormal_social/conspecific_i0.93920930
99MP0004270_analgesia0.93620571
100MP0002272_abnormal_nervous_system0.91903458
101MP0003633_abnormal_nervous_system0.91558158
102MP0005000_abnormal_immune_tolerance0.90088981
103MP0002127_abnormal_cardiovascular_syste0.89994430
104MP0002735_abnormal_chemical_nociception0.89555777
105MP0002184_abnormal_innervation0.88597712
106MP0003329_amyloid_beta_deposits0.88575611
107MP0002063_abnormal_learning/memory/cond0.88345448
108MP0003631_nervous_system_phenotype0.88213083
109MP0002102_abnormal_ear_morphology0.88194295
110MP0004924_abnormal_behavior0.87725735
111MP0005386_behavior/neurological_phenoty0.87725735
112MP0001485_abnormal_pinna_reflex0.87607594
113MP0004134_abnormal_chest_morphology0.87499506
114MP0002736_abnormal_nociception_after0.87434631
115MP0003115_abnormal_respiratory_system0.87286828
116MP0002751_abnormal_autonomic_nervous0.87234785
117MP0000716_abnormal_immune_system0.87130916
118MP0002163_abnormal_gland_morphology0.87038020
119MP0002152_abnormal_brain_morphology0.86652038
120MP0008007_abnormal_cellular_replicative0.85889793
121MP0004484_altered_response_of0.85803812
122MP0002229_neurodegeneration0.83607540
123MP0005253_abnormal_eye_physiology0.83053937
124MP0002638_abnormal_pupillary_reflex0.83036140
125MP0003183_abnormal_peptide_metabolism0.82328397
126MP0003937_abnormal_limbs/digits/tail_de0.81194975
127MP0003656_abnormal_erythrocyte_physiolo0.80868029
128MP0003938_abnormal_ear_development0.80442568
129MP0002132_abnormal_respiratory_system0.80263736
130MP0009250_abnormal_appendicular_skeleto0.80207226
131MP0008057_abnormal_DNA_replication0.78845170
132MP0002752_abnormal_somatic_nervous0.78587265
133MP0009697_abnormal_copulation0.78132111
134MP0003755_abnormal_palate_morphology0.77120325
135MP0000703_abnormal_thymus_morphology0.76951298
136MP0002075_abnormal_coat/hair_pigmentati0.76685796
137MP0003045_fibrosis0.76396244
138MP0001270_distended_abdomen0.76004828
139MP0001186_pigmentation_phenotype0.75744842
140MP0002009_preneoplasia0.75033417
141MP0002064_seizures0.72980980
142MP0002116_abnormal_craniofacial_bone0.72009465
143MP0001286_abnormal_eye_development0.71819986
144MP0001324_abnormal_eye_pigmentation0.71331992
145MP0000026_abnormal_inner_ear0.69894812
146MP0002882_abnormal_neuron_morphology0.69320682
147MP0006276_abnormal_autonomic_nervous0.69199404
148MP0002734_abnormal_mechanical_nocicepti0.68103042
149MP0001177_atelectasis0.67012675
150MP0001963_abnormal_hearing_physiology0.66946994
151MP0004742_abnormal_vestibular_system0.66827549
152MP0005391_vision/eye_phenotype0.66752056
153MP0001879_abnormal_lymphatic_vessel0.66186703
154MP0002109_abnormal_limb_morphology0.65785572
155MP0000681_abnormal_thyroid_gland0.65440710
156MP0005499_abnormal_olfactory_system0.63893498
157MP0005394_taste/olfaction_phenotype0.63893498
158MP0002398_abnormal_bone_marrow0.63764355
159MP0000534_abnormal_ureter_morphology0.63569049
160MP0010386_abnormal_urinary_bladder0.63025166
161MP0002233_abnormal_nose_morphology0.62583217
162MP0003861_abnormal_nervous_system0.62552647

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)3.29161127
2Hyperventilation (HP:0002883)3.28165670
3Papilledema (HP:0001085)3.04602491
4Abnormal hair whorl (HP:0010721)3.01908712
5Abnormality of the fingertips (HP:0001211)2.96633298
6Absent/shortened dynein arms (HP:0200106)2.90802290
7Dynein arm defect of respiratory motile cilia (HP:0012255)2.90802290
8Protruding tongue (HP:0010808)2.77999878
9Volvulus (HP:0002580)2.73043987
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71309042
11Abnormality of the right ventricle (HP:0001707)2.57607908
12Syringomyelia (HP:0003396)2.53877331
13Spinal cord lesions (HP:0100561)2.53877331
14Midline defect of the nose (HP:0004122)2.50653826
15Truncal obesity (HP:0001956)2.50517224
16True hermaphroditism (HP:0010459)2.50272141
17Agammaglobulinemia (HP:0004432)2.46574757
18Short 4th metacarpal (HP:0010044)2.46558379
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46558379
20Abnormal respiratory epithelium morphology (HP:0012253)2.45747652
21Abnormal respiratory motile cilium morphology (HP:0005938)2.45747652
22Neoplasm of the heart (HP:0100544)2.43928470
23Chronic hepatic failure (HP:0100626)2.43782961
24Eczematoid dermatitis (HP:0000976)2.41727551
25Abnormal ciliary motility (HP:0012262)2.41647146
26Pancreatic fibrosis (HP:0100732)2.39430518
27Amyotrophic lateral sclerosis (HP:0007354)2.38511403
28Nephroblastoma (Wilms tumor) (HP:0002667)2.37544619
29Panhypogammaglobulinemia (HP:0003139)2.35869846
30Embryonal renal neoplasm (HP:0011794)2.35820447
31Abnormality of the columella (HP:0009929)2.35659085
32Lip pit (HP:0100267)2.32248593
33Recurrent bacterial skin infections (HP:0005406)2.28943155
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25465426
35Postural instability (HP:0002172)2.23255138
36Decreased circulating renin level (HP:0003351)2.22950587
37Myositis (HP:0100614)2.22568103
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22163506
39Gait imbalance (HP:0002141)2.19896607
40Abnormality of the ischium (HP:0003174)2.18654196
41Retrobulbar optic neuritis (HP:0100654)2.18407906
42Optic neuritis (HP:0100653)2.18407906
43Vitreoretinal degeneration (HP:0000655)2.17887872
44Acute lymphatic leukemia (HP:0006721)2.17819060
45Gastrointestinal infarctions (HP:0005244)2.17240780
46Hypoplastic ischia (HP:0003175)2.15567476
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15350293
48Stomach cancer (HP:0012126)2.15098300
49Abnormal respiratory motile cilium physiology (HP:0012261)2.13180683
50Optic nerve coloboma (HP:0000588)2.10123290
51Abnormality of the nasal septum (HP:0000419)2.09881217
52Hemiplegia (HP:0002301)2.09382967
53Intestinal atresia (HP:0011100)2.08679356
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.08500269
55Medial flaring of the eyebrow (HP:0010747)2.07107737
56Hypochromic microcytic anemia (HP:0004840)2.05170993
57Chromsome breakage (HP:0040012)2.04284898
58Febrile seizures (HP:0002373)2.03623203
59Congenital primary aphakia (HP:0007707)2.03299332
60Abnormality of midbrain morphology (HP:0002418)1.99958166
61Molar tooth sign on MRI (HP:0002419)1.99958166
62Poor coordination (HP:0002370)1.99911436
63Hypothermia (HP:0002045)1.99638561
64Trigonocephaly (HP:0000243)1.98904750
65Broad-based gait (HP:0002136)1.98613195
66Abnormality of DNA repair (HP:0003254)1.98494145
67Generalized hypopigmentation of hair (HP:0011358)1.98277628
68Abnormality of the incisor (HP:0000676)1.98183204
69Tubulointerstitial abnormality (HP:0001969)1.96878069
70Gingivitis (HP:0000230)1.96802310
71Abnormality of incisor morphology (HP:0011063)1.96349329
72Epileptic encephalopathy (HP:0200134)1.95967542
73Recurrent sinusitis (HP:0011108)1.95927198
74Orchitis (HP:0100796)1.95722908
75Abnormality of the parietal bone (HP:0002696)1.94948580
76Recurrent fungal infections (HP:0002841)1.93354021
77Abnormality of the pubic bones (HP:0003172)1.93094372
78White forelock (HP:0002211)1.92753477
79Hypoplasia of the thymus (HP:0000778)1.92228286
80Narrow palate (HP:0000189)1.91219031
81Peritonitis (HP:0002586)1.90816784
82Recurrent abscess formation (HP:0002722)1.89025248
83Widely spaced teeth (HP:0000687)1.88606578
84Chronic mucocutaneous candidiasis (HP:0002728)1.87409949
85Recurrent cutaneous fungal infections (HP:0011370)1.87409949
86Ankle clonus (HP:0011448)1.85392112
87Postaxial foot polydactyly (HP:0001830)1.85360128
88Recurrent gram-negative bacterial infections (HP:0005420)1.85150835
89Morphological abnormality of the middle ear (HP:0008609)1.84262400
90Neoplasm of the tracheobronchial system (HP:0100552)1.84246931
91Stomatitis (HP:0010280)1.83590478
92Hypoplastic labia majora (HP:0000059)1.83408117
93Patchy hypopigmentation of hair (HP:0011365)1.81760302
94Abnormal number of incisors (HP:0011064)1.80413276
95Congenital stationary night blindness (HP:0007642)1.80297170
96Genital tract atresia (HP:0001827)1.79351013
97Abnormality of salivation (HP:0100755)1.79230571
98T lymphocytopenia (HP:0005403)1.78752643
99Germ cell neoplasia (HP:0100728)1.78189593
100Deep philtrum (HP:0002002)1.77253678
101Absent eyebrow (HP:0002223)1.77164624
102Mediastinal lymphadenopathy (HP:0100721)1.77115358
103Ectopic kidney (HP:0000086)1.76743475
104Gaze-evoked nystagmus (HP:0000640)1.75335366
105Thyroiditis (HP:0100646)1.75313677
106Vaginal atresia (HP:0000148)1.73991916
107Abnormality of the nasolacrimal system (HP:0000614)1.73954764
108Embryonal neoplasm (HP:0002898)1.73823946
109Colitis (HP:0002583)1.72922826
110Long eyelashes (HP:0000527)1.72671122
111Tented upper lip vermilion (HP:0010804)1.72276572
112Nephronophthisis (HP:0000090)1.70994188
113Leukocytosis (HP:0001974)1.70893378
114Severe visual impairment (HP:0001141)1.70184536
115Lower limb muscle weakness (HP:0007340)1.69707256
116Excessive salivation (HP:0003781)1.68837009
117Drooling (HP:0002307)1.68837009
118Growth hormone deficiency (HP:0000824)1.68736806
119Atonic seizures (HP:0010819)1.68371091
120Severe combined immunodeficiency (HP:0004430)1.67670427
121Spontaneous hematomas (HP:0007420)1.67258056
122Hepatoblastoma (HP:0002884)1.67075623
123Slow-growing hair (HP:0002217)1.67013112
124Abnormality of hair growth rate (HP:0011363)1.67013112
125Absent frontal sinuses (HP:0002688)1.66105357
126Hypoplasia of the brainstem (HP:0002365)1.65999835
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65999835
128Abnormality of the aortic arch (HP:0012303)1.65320028
129Cutaneous finger syndactyly (HP:0010554)1.65263465
130Obsessive-compulsive behavior (HP:0000722)1.65083898
131Lissencephaly (HP:0001339)1.64689442
132Hypoplasia of the maxilla (HP:0000327)1.63861520
133Abnormality of the lower motor neuron (HP:0002366)1.62317228
134Spastic gait (HP:0002064)1.61970352
135Preaxial hand polydactyly (HP:0001177)1.61822818
136Abnormality of eosinophils (HP:0001879)1.61811326
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.61529580
138Abnormality of the lacrimal duct (HP:0011481)1.61470328
139Pancreatic cysts (HP:0001737)1.60690234
140Hypoplastic female external genitalia (HP:0012815)1.60556019
141Cupped ear (HP:0000378)1.60527147
142Hypoplastic iliac wings (HP:0002866)1.60287932
143Abnormality of the labia majora (HP:0012881)1.59904520
144Alveolar cell carcinoma (HP:0006519)1.59331931
145Anteriorly placed anus (HP:0001545)1.59298393
146Abnormality of the renal medulla (HP:0100957)1.58992478
147Abnormality of T cell number (HP:0011839)1.58331323
148Polyphagia (HP:0002591)1.57534284
149Recurrent skin infections (HP:0001581)1.57152928
150Intellectual disability, moderate (HP:0002342)1.56842510
151Renal hypoplasia (HP:0000089)1.56699938
152Recurrent bronchitis (HP:0002837)1.56608781
153Supernumerary ribs (HP:0005815)1.55671156
154Rhinitis (HP:0012384)1.55504897
155Myelomeningocele (HP:0002475)1.55340689
156Elevated erythrocyte sedimentation rate (HP:0003565)1.55211852
157Urinary bladder sphincter dysfunction (HP:0002839)1.55152751
158Highly arched eyebrow (HP:0002553)1.54283657
159Keratoconus (HP:0000563)1.53506044
160Increased corneal curvature (HP:0100692)1.53506044
161Papillary thyroid carcinoma (HP:0002895)1.53290995
162Chronic diarrhea (HP:0002028)1.52864839
163Cutaneous syndactyly (HP:0012725)1.52462557
164B lymphocytopenia (HP:0010976)1.52316223
165Abnormality of B cell number (HP:0010975)1.52316223
166Anophthalmia (HP:0000528)1.51736495
167Progressive cerebellar ataxia (HP:0002073)1.51670493
168Chorioretinal coloboma (HP:0000567)1.51471972
169Narrow forehead (HP:0000341)1.51361119
170Submucous cleft hard palate (HP:0000176)1.51277694
171Labial hypoplasia (HP:0000066)1.51201659
172Nephrogenic diabetes insipidus (HP:0009806)1.50545290
173Supernumerary bones of the axial skeleton (HP:0009144)1.50292216
174Abnormality of the renal collecting system (HP:0004742)1.48916972
175Renal dysplasia (HP:0000110)1.48321002
176Hip dysplasia (HP:0001385)1.48255845
177Absent speech (HP:0001344)1.47966781
178Abnormality of the ileum (HP:0001549)1.47831925
179Abnormality of the intervertebral disk (HP:0005108)1.46093813
180Genetic anticipation (HP:0003743)1.45714530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.15341732
2CASK3.08834101
3INSRR2.72556921
4ERBB32.50295899
5SRPK12.45968102
6MAPK132.25871262
7BRD42.21889630
8MAP2K72.14208459
9SIK32.07445403
10ZAK2.01096707
11TAOK31.96642621
12SGK21.88441446
13AKT31.88279861
14CDK31.87611642
15BLK1.86154909
16PRPF4B1.82603075
17NUAK11.78586776
18FRK1.63398184
19PINK11.61279607
20YES11.58418397
21MKNK11.55658113
22NEK61.52544064
23DYRK1B1.50891030
24NTRK31.49262616
25TYRO31.46750742
26MAP3K61.43100856
27CLK11.42283905
28SIK21.41474857
29BMPR1B1.40977693
30TXK1.39865719
31FGFR21.38502162
32EPHB11.36552932
33MKNK21.34813395
34CCNB11.33635410
35TEC1.31973487
36TYK21.30943279
37MARK11.30489592
38IRAK41.26520044
39SGK31.26272230
40SGK4941.14804467
41SGK2231.14804467
42MAP3K41.13531093
43STK381.10983948
44FES1.09294374
45FGR1.06194576
46MAP2K41.05755849
47CAMK1G1.05715362
48JAK11.01726332
49CSK0.98409882
50PIK3CG0.98014273
51HCK0.96271495
52IRAK30.95780855
53MARK20.90892499
54CDC42BPA0.90876880
55MAP4K20.90803031
56CAMK10.90528819
57RET0.90527184
58BCR0.90174815
59OBSCN0.89760571
60FGFR30.89640778
61ATR0.89021708
62CDK120.87950001
63VRK10.87582057
64PAK30.87061422
65MAP3K130.86714666
66TAOK20.86252052
67PIK3CA0.84929094
68JAK20.84531633
69CAMKK20.81732818
70PLK40.81431990
71STK110.81346616
72BMPR20.79081678
73KIT0.78915025
74GRK60.76133141
75KSR10.75139386
76PLK20.75066427
77PTK2B0.74823132
78EPHA40.74156644
79CAMK40.73669861
80MYLK0.73336080
81MAPK70.73123542
82EIF2AK20.72806529
83TGFBR10.71307634
84NTRK20.69865183
85CDK80.69107178
86CSF1R0.69078785
87NLK0.68479472
88MAP3K70.67358386
89PNCK0.66995793
90CSNK1A1L0.65866945
91MAP3K140.64043125
92BTK0.63758444
93MAP3K100.63420302
94PDK10.63401726
95WNK10.63143743
96TGFBR20.62942633
97PRKCZ0.62709915
98WNK30.62566096
99PKN10.62153574
100CAMKK10.61210617
101CAMK1D0.60516782
102RIPK40.60073121
103PRKCH0.59192177
104RPS6KA20.59162804
105ITK0.59147493
106CDK50.59031875
107DYRK1A0.58690676
108CDK190.58042063
109PRKD20.58029675
110SGK10.58015200
111ERBB20.57312285
112IRAK20.57282867
113MAPK120.55631980
114FGFR40.55463404
115PDGFRB0.54153839
116IRAK10.52911741
117DYRK30.52844864
118RPS6KB10.51474203
119DAPK20.50763419
120PRKAA10.50625697
121TRPM70.48923567
122MAP4K10.48675273
123MAPK150.47817179
124TNK20.47709352
125SYK0.47379253
126LYN0.46945253
127JAK30.46229247
128ADRBK20.45762502
129ZAP700.43808900
130MAP2K60.43711907
131IKBKE0.42650668
132PLK30.42578195
133ATM0.42251582
134PRKCE0.41073219
135CHEK20.39908687
136EPHA30.39879499
137LCK0.38704080
138STK160.38121709
139PRKG10.37913512
140MARK30.37531967
141UHMK10.37215236
142DMPK0.36382800

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.05578974
2Primary immunodeficiency_Homo sapiens_hsa053401.76082418
3Non-homologous end-joining_Homo sapiens_hsa034501.62677393
4Fanconi anemia pathway_Homo sapiens_hsa034601.53170065
5Dorso-ventral axis formation_Homo sapiens_hsa043201.47925945
6Circadian entrainment_Homo sapiens_hsa047131.46693586
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42554539
8Taste transduction_Homo sapiens_hsa047421.42442836
9Morphine addiction_Homo sapiens_hsa050321.41481049
10Phototransduction_Homo sapiens_hsa047441.41025089
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34520674
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27746254
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24046043
14Glutamatergic synapse_Homo sapiens_hsa047241.22383164
15Long-term potentiation_Homo sapiens_hsa047201.22218134
16Staphylococcus aureus infection_Homo sapiens_hsa051501.20390285
17Serotonergic synapse_Homo sapiens_hsa047261.19196007
18Amphetamine addiction_Homo sapiens_hsa050311.13546537
19B cell receptor signaling pathway_Homo sapiens_hsa046621.12994813
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11900081
21Olfactory transduction_Homo sapiens_hsa047401.10832831
22Prolactin signaling pathway_Homo sapiens_hsa049171.09490319
23Axon guidance_Homo sapiens_hsa043601.08379455
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05389553
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03455287
26Dopaminergic synapse_Homo sapiens_hsa047281.02542021
27Cholinergic synapse_Homo sapiens_hsa047251.02235242
28RNA degradation_Homo sapiens_hsa030181.01733433
29ABC transporters_Homo sapiens_hsa020101.01592423
30Tuberculosis_Homo sapiens_hsa051521.01050139
31T cell receptor signaling pathway_Homo sapiens_hsa046601.00445078
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00383319
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00130495
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00054432
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99386708
36GABAergic synapse_Homo sapiens_hsa047270.98493050
37Calcium signaling pathway_Homo sapiens_hsa040200.98450612
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98415365
39Circadian rhythm_Homo sapiens_hsa047100.98058160
40Insulin secretion_Homo sapiens_hsa049110.97103277
41Long-term depression_Homo sapiens_hsa047300.96301144
42Type II diabetes mellitus_Homo sapiens_hsa049300.95849464
43Renin secretion_Homo sapiens_hsa049240.94463435
44mRNA surveillance pathway_Homo sapiens_hsa030150.93831517
45Wnt signaling pathway_Homo sapiens_hsa043100.92213702
46cAMP signaling pathway_Homo sapiens_hsa040240.91804920
47Non-small cell lung cancer_Homo sapiens_hsa052230.91088279
48Measles_Homo sapiens_hsa051620.89635210
49mTOR signaling pathway_Homo sapiens_hsa041500.89250663
50Herpes simplex infection_Homo sapiens_hsa051680.89140025
51Graft-versus-host disease_Homo sapiens_hsa053320.88627984
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88416754
53Hematopoietic cell lineage_Homo sapiens_hsa046400.88288314
54Cocaine addiction_Homo sapiens_hsa050300.87324807
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.86699064
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86670670
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.86500330
58Regulation of autophagy_Homo sapiens_hsa041400.83776361
59Allograft rejection_Homo sapiens_hsa053300.83203037
60Homologous recombination_Homo sapiens_hsa034400.83073052
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83047854
62Base excision repair_Homo sapiens_hsa034100.82834315
63Oxytocin signaling pathway_Homo sapiens_hsa049210.82739378
64Basal cell carcinoma_Homo sapiens_hsa052170.82669629
65Estrogen signaling pathway_Homo sapiens_hsa049150.82375207
66MAPK signaling pathway_Homo sapiens_hsa040100.82223358
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81248977
68Colorectal cancer_Homo sapiens_hsa052100.81221888
69Basal transcription factors_Homo sapiens_hsa030220.81040402
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80438183
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80396412
72VEGF signaling pathway_Homo sapiens_hsa043700.79477633
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79352022
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79054768
75Toxoplasmosis_Homo sapiens_hsa051450.78780633
76GnRH signaling pathway_Homo sapiens_hsa049120.78654249
77Spliceosome_Homo sapiens_hsa030400.78089247
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.76801113
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76156281
80Dilated cardiomyopathy_Homo sapiens_hsa054140.75939941
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.75418001
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74636411
83ErbB signaling pathway_Homo sapiens_hsa040120.73927364
84Ras signaling pathway_Homo sapiens_hsa040140.73560198
85Notch signaling pathway_Homo sapiens_hsa043300.72394325
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71286410
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71223201
88Chemokine signaling pathway_Homo sapiens_hsa040620.70271911
89Viral myocarditis_Homo sapiens_hsa054160.70003894
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.70001495
91Melanogenesis_Homo sapiens_hsa049160.69361351
92Rap1 signaling pathway_Homo sapiens_hsa040150.69124491
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68191627
94TNF signaling pathway_Homo sapiens_hsa046680.67993099
95Osteoclast differentiation_Homo sapiens_hsa043800.67125873
96Salivary secretion_Homo sapiens_hsa049700.66937765
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.66857917
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.66319957
99Alcoholism_Homo sapiens_hsa050340.65924319
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65627415
101Prostate cancer_Homo sapiens_hsa052150.65380137
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65311703
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64654741
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64479257
105Type I diabetes mellitus_Homo sapiens_hsa049400.64394650
106Autoimmune thyroid disease_Homo sapiens_hsa053200.63893046
107Endometrial cancer_Homo sapiens_hsa052130.63741209
108Malaria_Homo sapiens_hsa051440.63518087
109Hepatitis B_Homo sapiens_hsa051610.63421646
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62971208
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62939673
112Mismatch repair_Homo sapiens_hsa034300.62684016
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62575384
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62542524
115Inositol phosphate metabolism_Homo sapiens_hsa005620.62316606
116Hedgehog signaling pathway_Homo sapiens_hsa043400.61657545
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61259668
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60822256
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.60684068
120Platelet activation_Homo sapiens_hsa046110.59949764
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59584421
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58884522
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.58424828
124FoxO signaling pathway_Homo sapiens_hsa040680.58307402
125Influenza A_Homo sapiens_hsa051640.58207292
126Gastric acid secretion_Homo sapiens_hsa049710.57951182
127Cell cycle_Homo sapiens_hsa041100.57341146
128Choline metabolism in cancer_Homo sapiens_hsa052310.57268986
129Lysine degradation_Homo sapiens_hsa003100.57183592
130Pancreatic cancer_Homo sapiens_hsa052120.57161181
131Pathways in cancer_Homo sapiens_hsa052000.56856602
132Leishmaniasis_Homo sapiens_hsa051400.56135672
133Acute myeloid leukemia_Homo sapiens_hsa052210.55926203
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55357911
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54833208

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